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1. Distribution and diversity of classical deacylases in bacteria

Author

Graf, Leonie G., Moreno-Yruela, Carlos, Qin, Chuan, Schulze, Sabrina, Palm, Gottfried J., Schmöker, Ole, Wang, Nancy, Hocking, Dianna M., Jebeli, Leila, Girbardt, Britta, Berndt, Leona, Dörre, Babett, Weis, Daniel M., Janetzky, Markus, Albrecht, Dirk, Zühlke, Daniela, Sievers, Susanne, Strugnell, Richard A., Olsen, Christian A., Hofmann, Kay, and Lammers, Michael

Published
2024
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2. Recovery of dialysis patients with COVID-19: health outcomes 3 months after diagnosis in ERACODA

Author

Hemmelder, Marc H, Noordzij, Marlies, Vart, Priya, Hilbrands, Luuk B, Jager, Kitty J, Abrahams, Alferso C, Arroyo, David, Battaglia, Yuri, Ekart, Robert, Mallamaci, Francesca, Malloney, Sharon-Rose, Oliveira, Joao, Rydzewski, Andrzej, Sridharan, Sivakumar, Vogt, Liffert, Duivenvoorden, Raphaël, Gansevoort, Ron T, Franssen, Casper FM, van der Net, Jeroen B, Essig, Marie, du Buf-Vereijken, Peggy WG, van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C, Bemelman, Frederike J, Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G, Nurmohamed, Azam, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M, Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Hengst, Maaike, Konings, Constantijn JAM, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Alferes, Daniela G, Radulescu, Daniela, Zakharova, Elena V, Ambuehl, Patrice Max, Guidotti, Rebecca, Walker, Andrea, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, Katicic, Dajana, Dam, Marc ten, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L, Logtenberg, Susan JJ, Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen JP, ElHafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies EJ, Hesselink, Dennis A, van Gestel, J Kal-, Eiselt, Jaromir, Kielberger, Lukas, El-Wakil, Hala S, Verhoeven, Martine AM, Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M, Debska-Slizien, Alicja, Veldhuizen, Nicoline MH, Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Nistor, Ionut, Covic, Adrian, Groeneveld, JHM, Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, and dos Santos, Augusto Cesar Soares

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Patient Safety, Clinical Research, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Aged, Aged, 80 and over, COVID-19, COVID-19 Testing, Female, Humans, Intensive Care Units, Male, Middle Aged, Outcome Assessment, Health Care, Renal Dialysis, SARS-CoV-2, ERACODA Collaborators, dialysis, functional health status, mental health status, survival, Urology & Nephrology, Clinical sciences
Abstract

BackgroundCoronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months after their COVID-19 diagnosis.MethodsWe analyzed data on dialysis patients diagnosed with COVID-19 from 1 February 2020 to 31 March 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residence and functional and mental health status (estimated by their treating physician) 3 months after COVID-19 diagnosis. Complete follow-up data were available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression.ResultsIn 2449 hemodialysis patients (mean ± SD age 67.5 ± 14.4 years, 62% male), survival probabilities at 3 months after COVID-19 diagnosis were 90% for nonhospitalized patients (n = 1087), 73% for patients admitted to the hospital but not to an intensive care unit (ICU) (n = 1165) and 40% for those admitted to an ICU (n = 197). Patient survival hardly decreased between 28 days and 3 months after COVID-19 diagnosis. At 3 months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (0.8-6.3%) or a nursing home (∼5%). A higher age and frailty score at presentation and ICU admission were associated with worse functional outcome.ConclusionsMortality between 28 days and 3 months after COVID-19 diagnosis was low and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at 3 months after diagnosis.

Published
2022

3. finDr: A web server for in silico D-peptide ligand identification

Author

Engel, Helena, Guischard, Felix, Krause, Fabian, Nandy, Janina, Kaas, Paulina, Höfflin, Nico, Köhn, Maja, Kilb, Normann, Voigt, Karsten, Wolf, Steffen, Aslan, Tahira, Baezner, Fabian, Hahne, Salomé, Ruckes, Carolin, Weygant, Joshua, Zinina, Alisa, Akmeriç, Emir Bora, Antwi, Enoch B., Dombrovskij, Dennis, Franke, Philipp, Lesch, Klara L., Vesper, Niklas, Weis, Daniel, Gensch, Nicole, Di Ventura, Barbara, and Öztürk, Mehmet Ali

Published
2021
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4. Mechanism and site of action of big dynorphin on ASIC1a

Author

Borg, Christian B., Braun, Nina, Heusser, Stephanie A., Bay, Yasmin, Weis, Daniel, Galleano, Iacopo, Lund, Camilla, Tian, Weihua, Haugaard-Kedström, Linda M., Bennett, Eric P., Lynagh, Timothy, Strømgaard, Kristian, Andersen, Jacob, and Pless, Stephan A.

Published
2020

6. Association of obesity with 3-month mortality in kidney failure patients with COVID-19

Author

Tantisattamo, Ekamol, Imhof, Celine, Jager, Kitty J., Hilbrands, Luuk B., Guidotti, Rebecca, Islam, Mahmud, Katicic, Dajana, Konings, Constantijn, Molenaar, Femke M., Nistor, Ionut, Noordzij, Marlies, Rodríguez Ferrero, Mariá Luisa, Verhoeven, Martine A. M., de Vries, Aiko P. J., Kalantar-Zadeh, Kamyar, Gansevoort, Ron T., Vart, Priya, van der Net, Jeroen B., Essig, Marie, du Buf-Vereijken, Peggy W. G., van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C., Bemelman, Frederike J., Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G., Nurmohamed, Azam, Vogt, Liffert, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M., Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Radulescu, Daniela, Hengst, Maaike, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, Joaõ, Alferes, Daniela G., Zakharova, Elena V., Ambuehl, Patrice Max, Walker, Andrea, Lepeytre, Fanny, Rabate, Clementine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L., Logtenberg, Susan J. J., Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J. P., Elhafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E. J., Hesselink, Dennis A., Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, el-Wakil, Hala S., Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M., Debska-Slizien, Alicja, Veldhuizen, Nicoline M. H., Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Covic, Adrian, Groeneveld, J. H. M., Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, Santos, Augusto Cesar S., Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M., Siezenga, Machiel A., Franco, Antonio, Arroyo, David, Castellano, Sandra, Manzanos, Sagrario Balda, Haridian Sosa Barrios, R., Lemahieu, Wim, Bartelet, Karlijn, Dirim, Ahmet Burak, Demir, Erol, Sever, Mehmet Sukru, Turkmen, Aydin, Safak, Seda, Hollander, Daan A. M. J., Büttner, Stefan, Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petruliene, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M., Christiaans, Maarten H. L., Hemmelder, Marc H., Kumar, Mohan N., di Luca, Marina, Tuǧlular, Serhan Z., Ziekenhuis, Martini, Kramer, Andrea B., Beerenhout, Charles, Luik, Peter T., Kerschbaum, Julia, Tiefenthaler, Martin, Watschinger, Bruno, Adema, Aaltje Y., Stepanov, Vadim A., Zulkarnaev, Alexey B., Turkmen, Kultigin, Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W. H., Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, Els van de Logt, Anne, Maas, Rutger, Duivenvoorden, Raphaël, Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J. M., Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V., Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E. A., Harty, John C., Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Schouten, Marcel, Rychlik, Ivan, Cabezas-Reina, Carlos J., Roca, Ana Maria, Nauta, Ferdau, Sahin, Idris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K. I., Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M., Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P., Meijer, Esther, Sanders, Jan Stephan F., Franssen, Casper F. M., Özyilmaz, Akin, Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C., van Zuilen, Arjan D., Meijvis, Sabine C. A., Dolmans, Helma, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Soler, Maria Jose, Luik, Antinus J., van Kuijk, Willi H. M., Stikkelbroeck, Lonneke W. H., Hermans, Marc M. H., Rimsevicius, Laurynas, Righetti, Marco, Heitink-ter Braak, Nicole, Medical Informatics, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, ACS - Pulmonary hypertension & thrombosis, Nephrology, ACS - Microcirculation, APH - Health Behaviors & Chronic Diseases, Clinical sciences, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, ACS - Diabetes & metabolism, Internal Medicine, Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), van der Net, Jeroen B, Essig, Marie, du Buf-Vereijken, Peggy W G, van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C, Bemelman, Frederike J, Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G, Nurmohamed, Azam, Vogt, Liffert, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M, Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Radulescu, Daniela, Hengst, Maaike, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G, Zakharova, Elena V, Ambuehl, Patrice Max, Walker, Andrea, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, Ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L, Logtenberg, Susan J J, Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J P, ElHafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E J, Hesselink, Dennis A, Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, El-Wakil, Hala S, Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M, Debska-Slizien, Alicja, Veldhuizen, Nicoline M H, Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Covic, Adrian, Groeneveld, J H M, Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, Santos, Augusto Cesar S, Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M, Siezenga, Machiel A, Franco, Antonio, Arroyo, David, Castellano, Sandra, Manzanos, Sagrario Balda, Haridian Sosa Barrios, R., Lemahieu, Wim, Bartelet, Karlijn, Dirim, Ahmet Burak, Demir, Erol, Sever, Mehmet Sukru, Turkmen, Aydin, Şafak, Seda, Hollander, Daan A M J, Büttner, Stefan, Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petrulienė, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M, Christiaans, Maarten H L, Hemmelder, Marc H, Kumar N, Mohan, Di Luca, Marina, Tuğlular, Serhan Z, Ziekenhuis, Martini, Kramer, Andrea B, Beerenhout, Charles, Luik, Peter T, Kerschbaum, Julia, Tiefenthaler, Martin, Watschinger, Bruno, Adema, Aaltje Y, Stepanov, Vadim A, Zulkarnaev, Alexey B, Turkmen, Kultigin, Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W H, Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, Els van de Logt, Anne, Maas, Rutger, Duivenvoorden, Raphaël, Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J M, Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V, Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E A, Harty, John C, Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Schouten, Marcel, Rychlik, Ivan, Cabezas-Reina, Carlos J, Roca, Ana Maria, Nauta, Ferdau, Sahin, İdris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K I, Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M, Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P, Meijer, Esther, Sanders, Jan Stephan F, Franssen, Casper F M, Özyilmaz, Akin, Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C, van Zuilen, Arjan D, Meijvis, Sabine C A, Dolmans, Helma, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Soler, Maria Jose, Luik, Antinus J, van Kuijk, Willi H M, Stikkelbroeck, Lonneke W H, Hermans, Marc M H, Rimševičius, Laurynas, Righetti, Marco, and Heitink-Ter Braak, Nicole

Subjects
Transplantation, COVID-19, infectious diseases, mortality, DIALYSIS PATIENTS, kidney failure, BODY-MASS INDEX, obesity paradox, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], TRANSPLANT, SDG 3 - Good Health and Well-being, Nephrology, ERACODA, reverse epidemiology, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
Abstract

Background In the general population with coronavirus disease 2019 (COVID-19), obesity is associated with an increased risk of mortality. Given the typically observed obesity paradox among patients on kidney function replacement therapy (KFRT), especially dialysis patients, we examined the association of obesity with mortality among dialysis patients or living with a kidney transplant with COVID-19. Methods Data from the European Renal Association COVID-19 Database (ERACODA) were used. KFRT patients diagnosed with COVID-19 between 1 February 2020 and 31 January 2021 were included. The association of Quetelet's body mass index (BMI) (kg/m2), divided into: Results In 3160 patients on KFRT (mean age: 65 years, male: 61%), 99 patients were lean, 1151 normal weight (reference), 1160 overweight, 525 obese I and 225 obese II/III. During follow-up of 3 months, 28, 20, 21, 23 and 27% of patients died in these categories, respectively. In the fully adjusted model, the hazard ratios (HRs) for 3-month mortality were 1.65 [95% confidence interval (CI): 1.10, 2.47], 1 (ref.), 1.07 (95% CI: 0.89, 1.28), 1.17 (95% CI: 0.93, 1.46) and 1.71 (95% CI: 1.27, 2.30), respectively. Results were similar among dialysis patients (N = 2343) and among those living with a kidney transplant (N = 817) (Pinteraction = 0.99), but differed by sex (Pinteraction = 0.019). In males, the HRs for the association of aforementioned BMI categories with 3-month mortality were 2.07 (95% CI: 1.22, 3.52), 1 (ref.), 0.97 (95% CI: 0.78. 1.21), 0.99 (95% CI: 0.74, 1.33) and 1.22 (95% CI: 0.78, 1.91), respectively, and in females corresponding HRs were 1.34 (95% CI: 0.70, 2.57), 1 (ref.), 1.31 (95% CI: 0.94, 1.85), 1.54 (95% CI: 1.05, 2.26) and 2.49 (95% CI: 1.62, 3.84), respectively. Conclusion In KFRT patients with COVID-19, on dialysis or a kidney transplant, obesity is associated with an increased risk of mortality at 3 months. This is in contrast to the obesity paradox generally observed in dialysis patients. Additional studies are required to corroborate the sex difference in the association of obesity with mortality.

Published
2022
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9. Validität in multi-methodischen Forschungsdesigns: Reflexion von Herausforderungen in der Erforschung komplexer Fragestellungen.

Author

Weis, Daniel, Grimm, Sandra Biewers, and Latz, Anita

Abstract

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Published
2024
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10. Analysis of Slow-Cycling Variants of the Light-Inducible Nuclear Protein Export System LEXY in Mammalian Cells

Author

Forlani, Giada, Antwi, Enoch B., Weis, Daniel, Öztürk, Mehmet A., Queck, Bastian A.W., Brecht, Dominik, and Di Ventura, Barbara

Subjects
Nuclear Export Signals, Oxygen, Mammals, Phototropins, Tumor Necrosis Factor Ligand Superfamily Member 14, Light, Avena, Biomedical Engineering, Animals, Nuclear Proteins, General Medicine, Biochemistry, Genetics and Molecular Biology (miscellaneous)
Abstract

The optogenetic tool LEXY consists of the second light oxygen voltage (LOV) domain of

Published
2022
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11. Für sich selbst und das Leben lernen: Worin Jugendliche das Bildungspotential der offenen Jugendarbeit sehen

Author

Latz, Anita, Weis, Daniel, Biewers, Sandra, Ministry of National Education, Childhood and Youth [sponsor], and Centre for Childhood- und Youth Research (CCY) [research center]

Subjects
youth studies, Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie], Sociology & social sciences [H10] [Social & behavioral sciences, psychology], youth work, nonformal education
Published
2023

12. Perspectives on Youth Work in Luxembourg (PYL): Eine empirische Studie über Verständnis, Interpretationen und Perspektiven auf Jugendarbeit in Luxemburg - Vorstellung des Forschungskonzepts

Author

Centre for Childhood und Youth Research (CCY) [research center], Ministry of National Education, Childhood and Youth [sponsor], Weis, Daniel, Biewers, Sandra, Latz, Anita, Centre for Childhood und Youth Research (CCY) [research center], Ministry of National Education, Childhood and Youth [sponsor], Weis, Daniel, Biewers, Sandra, and Latz, Anita

Published
2023

15. Bildungserfahrungen in non-formalen Settings. Eine Mixed-Methods-Studie über das Bildungspotential und den Wert von Jugendarbeit aus der Sicht von Jugendlichen in Luxemburg.

Author

Centre for Childhood- und Youth Research (CCY) [research center], Ministry of National Education, Childhood and Youth [sponsor], Biewers, Sandra, Latz, Anita, Weis, Daniel, Centre for Childhood- und Youth Research (CCY) [research center], Ministry of National Education, Childhood and Youth [sponsor], Biewers, Sandra, Latz, Anita, and Weis, Daniel

Published
2023

19. Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy

Author

Vart, Priya, Duivenvoorden, Raphaël, Adema, Aaltje, Covic, Adrian, Finne, Patrik, Braak, Nicole Heijtink-ter, Laine, Kaisa, Noordzij, Marlies, Schouten, Marcel, Jager, Kitty J., Gansevoort, Ron T., van der Net, Jeroen B., Essig, Marie, du Buf-Vereijken, Peggy W. G., van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C., Bemelman, Frederike J., Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G., Nurmohamed, Azam, Vogt, Liffert, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M., Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Radulescu, Daniela, Hengst, Maaike, Konings, Constantijn, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G., Zakharova, Elena V., Ambühl, Patrice Max, Guidotti, Rebecca, Walker, Andrea, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, Katicic, Dajana, ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L., Logtenberg, Susan J. J., Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J. P., ElHafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E. J., Hesselink, Dennis A., Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, El-Wakil, Hala S., Verhoeven, Martine, Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M., Debska-Slizien, Alicja, Veldhuizen, Nicoline M. H., Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Nistor, Ionut, Groeneveld, J. H.M., Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, Santos, Augusto Cesar S., Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M., Siezenga, Machiel A., Franco, Antonio, Arroyo, David, Castellano, Sandra, Rodríguez-Ferrero, Maria Luisa, Manzanos, Sagrario Balda, Barrios, R. Haridian Sosa, Lemahieu, Wim, Bartelet, Karlijn, Dirim, Ahmet Burak, Demir, Erol, Sever, Mehmet Sukru, Turkmen, Aydin, Şafak, Seda, Hollander, Daan A. M. J., Büttner, Stefan, de Vries, Aiko P. J., Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petrulienė, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M., Christiaans, Maarten H. L., Hemmelder, Marc H., MohanKumar, N., Di Luca, Marina, Tuğlular, Serhan Z., Kramer, Andrea B., Beerenhout, Charles, Luik, Peter T., Kerschbaum, Julia, Tiefenthaler, Martin, Watschinger, Bruno, Stepanov, Vadim A., Zulkarnaev, Alexey B., Turkmen, Kultigin, Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W. H., Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, van de Logt, Anne Els, Maas, Rutger, Hilbrands, Luuk B., Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J. M., Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V., Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E. A., Harty, John C., Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Rychlik, Ivan, Cabezas-Reina, Carlos J., Roca, Ana Maria, Nauta, Ferdau, Sahin, İdris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K. I., Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M., Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P., Sanders, Jan Stephan F., Franssen, Casper F. M., Özyilmaz, Akin, Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C., Molenaar, Femke M., van Zuilen, Arjan D., Meijvis, Sabine C. A., Dolmans, Helma, Tantisattamo, Ekamol, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Soler, Maria Jose, Luik, Antinus J., van Kuijk, Willi H. M., Stikkelbroeck, Lonneke W. H., Hermans, Marc M. H., Rimševičius, Laurynas, Righetti, Marco, Islam, Mahmud, Clinical sciences, Nephrology, Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Medical Informatics, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, ACS - Microcirculation, APH - Health Behaviors & Chronic Diseases, Internal Medicine, Department of Medicine, Clinicum, University of Helsinki, Helsinki University Hospital Area, ACS - Diabetes & metabolism, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, and UCL - (SLuc) Service de néphrologie

Subjects
Male, kidney, Transplant, infectious diseases, Kidney, All institutes and research themes of the Radboud University Medical Center, COVID‐19, Renal Dialysis, Risk Factors, risk factors, Humans, Eracoda, Aged, Sex Characteristics, Multidisciplinary, Dialysis patients, Kidney Transplantation/adverse effects, COVID-19, Middle Aged, Kidney Transplantation, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Nephrology, 3121 General medicine, internal medicine and other clinical medicine, mortality risk, Immunosuppressive Agents/therapeutic use, Female, Immunosuppressive Agents
Abstract

In the general population with COVID-19, the male sex is an established risk factor for mortality, in part due to a more robust immune response to COVID-19 in women. Because patients on kidney function replacement therapy (KFRT) have an impaired immune response, especially kidney transplant recipients due to their use of immunosuppressants, we examined whether the male sex is still a risk factor for mortality among patients on KFRT with COVID-19. From the European Renal Association COVID-19 Database (ERACODA), we examined patients on KFRT with COVID-19 who presented between February 1st, 2020, and April 30th, 2021. 1204 kidney transplant recipients (male 62.0%, mean age 56.4 years) and 3206 dialysis patients (male 61.8%, mean age 67.7 years) were examined. Three-month mortality in kidney transplant recipients was 16.9% in males and 18.6% in females (p = 0.31) and in dialysis patients 27.1% in males and 21.9% in females (p = 0.001). The adjusted HR for the risk of 3-month mortality in males (vs females) was 0.89 (95% CI 65, 1.23, p = 0.49) in kidney transplant recipients and 1.33 (95% CI 1.13, 1.56, p = 0.001) in dialysis patients (pinteraction = 0.02). In a fully adjusted model, the aHR for the risk of 3-month mortality in kidney transplant recipients (vs. dialysis patients) was 1.39 (95% CI 1.02, 1.89, p = 0.04) in males and 2.04 (95% CI 1.40, 2.97, p interaction = 0.02). In patients on KFRT with COVID-19, the male sex is not a risk factor for mortality among kidney transplant recipients but remains a risk factor among dialysis patients. The use of immunosuppressants in kidney transplant recipients, among other factors, may have narrowed the difference in the immune response to COVID-19 between men and women, and therefore reduced the sex difference in COVID-19 mortality risk.

Published
2022
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21. Clinical, Functional, and Mental Health Outcomes in Kidney Transplant Recipients 3 Months After a Diagnosis of COVID-19

Author

Duivenvoorden, Raphaël, Vart, Priya, Noordzij, Marlies, Soares Dos Santos, Augusto C., Zulkarnaev, Alex B., Franssen, Casper F. M., Kuypers, Dirk, Demir, Erol, Rahimzadeh, Hormat, Kerschbaum, Julia, Jager, Kitty J., Turkmen, Kultigin, Hemmelder, Marc H., Schouten, Marcel, Rodríguez-Ferrero, María Luisa, Crespo, Marta, Gansevoort, Ron T., Hilbrands, Luuk B., van der Net, Jeroen B., Essig, Marie, du Buf-Vereijken, Peggy W. G., van Ginneken, Betty, Maas, Nanda, Vogt, Liffert, van Jaarsveld, Brigit C., Bemelman, Frederike J., Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G., Nurmohamed, Azam, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M., Montero Perez, Nuria, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Hengst, Maaike, Konings, Constantijn, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G., Radulescu, Daniela, Zakharova, Elena V., Ambuehl, Patrice Max, Guidotti, Rebecca, Walker, Andrea, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Strazmester Majstorovic, Gordana, Katicic, Dajana, ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L., Logtenberg, Susan J. J., Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J. P., Abd Elhafeez, Samar, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E. J., Hesselink, Dennis A., Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, el-Wakil, Hala S., Verhoeven, Martine, Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M., Debska-Slizien, Alicja, Veldhuizen, Nicoline M. H., Tigka, Eirini, Polyzou Konsta, Maria Anna, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Nistor, Ionut, Covic, Adrian, Groeneveld, J. H. M., Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Assis Pereira, Tiago, Arias-Cabrales, Carlos, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M., Siezenga, Machiel A., Franco, Antonio, Arroyo, David, Castellano, Sandra, Balda Manzanos, Sagrario, Sosa Barrios, R. Haridian, Lemahieu, Wim, Bartelet, Karlijn, Burak Dirim, Ahmet, Sukru Sever, Mehmet, Turkmen, Aydin, Şafak, Seda, Hollander, Daan A. M. J., Büttner, Stefan, de Vries, Aiko P. J., Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petruliene, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M., Christiaans, Maarten H. L., Mohan Kumar, N., di Luca, Marina, Tuǧlular, Serhan Z., Kramer, Andrea, Beerenhout, Charles, Luik, Peter T., Tiefenthaler, Martin, Watschinger, Bruno, Adema, Aaltje Y., Stepanov, Vadim A., Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W. H., Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, van de Logt, Anne Els, Maas, Rutger, Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J. M., Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V., Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E. A., Harty, John C., Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rychlik, Ivan, Cabezas-Reina, Carlos J., Maria Roca, Ana, Nauta, Ferdau, Sahin, İdris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K. I., Naesens, Maarten, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M., Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P., Meijer, Esther, Sanders, Jan Stephan F., Özyilmaz, Akin, Buturović Ponikvar, Jadranka, Marn Pernat, Andreja, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C., Molenaar, Femke M., van Zuilen, Arjan D., Meijvis, Sabine C. A., Dolmans, Helma, Tantisattamo, Ekamol, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Jose Soler, Maria, Luik, Antinus J., van Kuijk, Willi H. M., Stikkelbroeck, Lonneke W. H., Hermans, Marc M. H., Rimsevicius, Laurynas, Righetti, Marco, Islam, Mahmud, Heitink-ter Braak, Nicole, Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Medical Informatics, ACS - Pulmonary hypertension & thrombosis, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, Nephrology, ACS - Diabetes & metabolism, Internal Medicine, Interne Geneeskunde, RS: Carim - V02 Hypertension and target organ damage, and Clinical sciences

Subjects
kidney transplant, Adult, Kidney Disease, Outcome Assessment, Renal and urogenital, infectious diseases, Medical and Health Sciences, clinical, DISEASE, All institutes and research themes of the Radboud University Medical Center, Rare Diseases, SDG 3 - Good Health and Well-being, 7.1 Individual care needs, Clinical Research, Outcome Assessment, Health Care, Humans, Retrospective Studies, Transplantation, SARS-CoV-2, MORTALITY, Rehabilitation, COVID-19, mental health outcomes, survive, Organ Transplantation, Original Clinical Science—General, Middle Aged, SOLID-ORGAN TRANSPLANT, Kidney Transplantation, Transplant Recipients, DIALYSIS PATIENTS, Health Care, functional, Intensive Care Units, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Good Health and Well Being, Nephrology, ERACODA, ERACODA Collaborators, Surgery, Management of diseases and conditions, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
Abstract

BACKGROUND: Kidney transplant patients are at high risk for coronavirus disease 2019 (COVID-19)-related mortality. However, limited data are available on longer-term clinical, functional, and mental health outcomes in patients who survive COVID-19.METHODS: We analyzed data from adult kidney transplant patients in the European Renal Association COVID-19 Database who presented with COVID-19 between February 1, 2020, and January 31, 2021.RESULTS: We included 912 patients with a mean age of 56.7 (±13.7) y. 26.4% were not hospitalized, 57.5% were hospitalized without need for intensive care unit (ICU) admission, and 16.1% were hospitalized and admitted to the ICU. At 3 mo follow-up survival was 82.3% overall, and 98.8%, 84.2%, and 49.0%, respectively, in each group. At 3 mo follow-up biopsy-proven acute rejection, need for renal replacement therapy, and graft failure occurred in the overall group in 0.8%, 2.6%, and 1.8% respectively, and in 2.1%, 10.6%, and 10.6% of ICU-admitted patients, respectively. Of the surviving patients, 83.3% and 94.4% reached their pre-COVID-19 physician-reported functional and mental health status, respectively, within 3 mo. Of patients who had not yet reached their prior functional and mental health status, their treating physicians expected that 79.6% and 80.0%, respectively, still would do so within the coming year. ICU admission was independently associated with a low likelihood to reach prior functional and mental health status.CONCLUSIONS: In kidney transplant recipients alive at 3-mo follow-up, clinical, physician-reported functional, and mental health recovery was good for both nonhospitalized and hospitalized patients. Recovery was, however, less favorable for patients who had been admitted to the ICU.

Published
2022
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22. Theoretical and empirical perspectives on the value of non-formal education

Author

Centre for Childhood and Youth Research [research center], Ministry of Education, Children and Youth and University of Luxembourg [sponsor], Biewers, Sandra, Weis, Daniel, Latz, Anita, Centre for Childhood and Youth Research [research center], Ministry of Education, Children and Youth and University of Luxembourg [sponsor], Biewers, Sandra, Weis, Daniel, and Latz, Anita

Abstract

Due to its principles of voluntariness and openness and because of its diverse offer of subject-related educational opportunities, open youth work has a high potential to support young people in their development and self-education. These learning and educational opportunities are holistic and comprehensive and often go far beyond the acquisition of skills and competences. How can these educational processes be described empirically and what form of education can be spoken of here at all? These questions are addressed by the qualitative-reconstructive study "Educational Experiences in Non-formal Settings", which is conducted at the Centre for Childhood and Youth Research (CCY) at the University of Luxembourg. The study examines the subjective educational experiences of young people in open youth work from various perspectives: on the basis of participant observations in youth centres, in problem-centred interviews and group discussions with young people, as well as via a complementary quantitative survey of young people.

Published
2022

25. Theoretical and empirical perspectives on the value of non-formal education

Author

Biewers, Sandra, Weis, Daniel, Latz, Anita, Ministry of Education, Children and Youth and University of Luxembourg [sponsor], and Centre for Childhood and Youth Research [research center]

Subjects
youth research, Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie], Sociology & social sciences [H10] [Social & behavioral sciences, psychology], non-formal education, mixed-methods-design
Abstract

Due to its principles of voluntariness and openness and because of its diverse offer of subject-related educational opportunities, open youth work has a high potential to support young people in their development and self-education. These learning and educational opportunities are holistic and comprehensive and often go far beyond the acquisition of skills and competences. How can these educational processes be described empirically and what form of education can be spoken of here at all? These questions are addressed by the qualitative-reconstructive study "Educational Experiences in Non-formal Settings", which is conducted at the Centre for Childhood and Youth Research (CCY) at the University of Luxembourg. The study examines the subjective educational experiences of young people in open youth work from various perspectives: on the basis of participant observations in youth centres, in problem-centred interviews and group discussions with young people, as well as via a complementary quantitative survey of young people.

Published
2022

30. Enhancement of reactor coolant leakage measurement using radiation instrumentation

Author

Weis, Daniel G.

Subjects
Nuclear reactors -- Equipment and supplies, Coolant -- Research, Business, Electronics, Electronics and electrical industries
Abstract

The detection of Reactor Coolant System (RCS) leakage inside containment with sampling radiation monitors located outside containment is reviewed. The target for the radiation monitor response is the clear indication of a one gpm increase in RCS leakage within one hour. The limitations of present methods using beta sensitive detectors are discussed. The limitations are often due to the detection of interfering radioactive materials not related to RCS leakage. Modeling of radioactive material buildup from leakage is used to predict the response of gamma sensitive detectors operated in spectral modes. This would allow isolating isotopes responsive from leak detection considerations from isotopes unresponsive and from isotopes unrelated to RCS leakage.

Published
1999

31. Radiation Monitoring

Author

Lingren, Clinton L., primary, Weis, Daniel, additional, Bleher, George L., additional, and Giegler, Donald P., additional

Published
2005
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32. Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia

Author

Kaesler, Nadine, Kaesler, Nadine, Goettsch, Claudia, Weis, Daniel, Schurgers, Leon, Hellmann, Burkhard, Floege, Juergen, Kramann, Rafael, Kaesler, Nadine, Kaesler, Nadine, Goettsch, Claudia, Weis, Daniel, Schurgers, Leon, Hellmann, Burkhard, Floege, Juergen, and Kramann, Rafael

Abstract

Background. Optimal phosphate control is an unmet need in chronic kidney disease (CKD). High serum phosphate increases calcification burden and is associated with mortality and cardiovascular disease in CKD. Nicotinamide (NA) alone or in combination with calcium-free phosphate binders might be a strategy to reduce phosphate levels and calcification and thus impact cardiovascular disease in CKD.Methods. We studied the effect of NA alone and in combination with magnesium carbonate (MgCO3) as a potential novel treatment strategy. CKD was induced in dilute brown non-agouti/2 mice by subtotal nephrectomy followed by a high-phosphate diet (HP) and 7 weeks of treatment with NA, MgCO3 or their combination. Control mice underwent subtotal nephrectomy and received an HP or underwent sham surgery and received standard chow plus NA.Results. CKD mice showed increased serum fibroblast growth factor 23 and calcium-phosphate product that was normalized by all treatment regimes. NA alone increased soft tissue and vascular calcification, whereas any treatment with MgCO3 significantly reduced calcification severity in CKD. While MgCO3 supplementation alone resulted in decreased calcification severity, it resulted in increased intestinal expression of the phosphate transporters type II sodium-dependent phosphate transporter 1 (Pit-1). Combined therapy of MgCO3 and NA reduced tissue calcification and normalized expression levels of intestinal phosphate transporter proteins.Conclusions. In conclusion, the data indicate that NA increases while MgCO3 reduces ectopic calcification severity. Augmented expression of intestinal phosphate transporters by MgCO3 treatment was abolished by the addition of NA. However, the clinical relevance of the latter remains to be explored. Importantly, the data suggest no benefit of NA regarding treatment of calcification in addition to MgCO3.

Published
2020

33. Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction

Author

Borg, Christian B., Braun, Nina, Heusser, Stephanie A., Bay, Yasmin, Weis, Daniel, Galleano, Iacopo, Lund, Camilla, Tian, Weihua, Haugaard-Kedstrom, Linda M., Bennett, Eric P., Lynagh, Timothy, Stromgaard, Kristian, Andersen, Jacob, Pless, Stephan A., Borg, Christian B., Braun, Nina, Heusser, Stephanie A., Bay, Yasmin, Weis, Daniel, Galleano, Iacopo, Lund, Camilla, Tian, Weihua, Haugaard-Kedstrom, Linda M., Bennett, Eric P., Lynagh, Timothy, Stromgaard, Kristian, Andersen, Jacob, and Pless, Stephan A.

Published
2020

34. Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction

Author

Borg, Christian B., primary, Braun, Nina, additional, Heusser, Stephanie A., additional, Bay, Yasmin, additional, Weis, Daniel, additional, Galleano, Iacopo, additional, Lund, Camilla, additional, Tian, Weihua, additional, Haugaard-Kedström, Linda M., additional, Bennett, Eric P., additional, Lynagh, Timothy, additional, Strømgaard, Kristian, additional, Andersen, Jacob, additional, and Pless, Stephan A., additional

Published
2020
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37. Perspectives and transition experiences of adolescents and young adults with disabilities

Author

Weis, Daniel and Mousset, Isabelle

Subjects
inclusion, young people with disabilities, transition experiences, Multidisciplinary, general & others [H99] [Social & behavioral sciences, psychology], autonomy, Multidisciplinaire, généralités & autres [H99] [Sciences sociales & comportementales, psychologie], exclusion, dependency
Abstract

Aims: The focus of the presentation is the specific situation of young people with disabilities during their transition period into adulthood. Methods: The presentation is based on 51 guideline-based qualitative interviews with adolescents and young adults with a disability. The study was conducted within the framework of the Luxembourg Youth Report 2015 (Willems, 2015). Results: The aspirations and ideas of young people with disabilities about being and becoming an adult are little different from those of their able-bodied peers. For them, too, being an adult primarily means financial, emotional and social independence and autonomy. Nevertheless, it is obvious that for them the transition to self-reliant, independent adult life is more difficult: only one in seven of those questioned had found their first job on the labour market and one in two were still living with their parents. Conclusion: Our conclusion is that for adolescents and young adults with a disability, the transition to adulthood presents a disproportionately tough challenge compared with their able-bodied peers. Sociological and psychological theories (Hurrelmann & Quenzel, 2012; Havighurst, 1972) consider the successful accomplishment of certain developmental tasks as a master challenge of youth. Young people with disabilities have to cope with the same developmental tasks as young people without disabilities. However, achieving them is much more difficult, not only because of their physical, mental or psychiatric impairment but also because of the lack of respect and the stigmatisation that they experience in daily life.

Published
2017

40. Midterm Evaluation Erasmus+. Evaluationsstudie zur Implementierung von Erasmus+ in Luxemburg

Author

Weis, Daniel, Meyers, Christiane, Willems, Helmut, Ministère de l'Éducation nationale, de l'Enfance et de la Jeunesse [sponsor], and Integrative Research Unit: Social and Individual Development (INSIDE) > Institute for Research on Generations and Family [research center]

Subjects
Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie], Youth, Luxembourg, Sociology & social sciences [H10] [Social & behavioral sciences, psychology], Erasmus+
Abstract

Der vorliegende Bericht stellt die Ergebnisse der Zwischenevaluation über die Durchführung und die Wirkung des Programms Erasmus+ in Luxemburg vor. Mit der Durchführung der Evaluation und der Berichterstellung wurde die Jugendforschung der Universität Luxemburg unter Leitung von Prof. Dr. Helmut Willems vom zuständigen Ministerium (Ministère de l'Éducation nationale, de l'Enfance et de la Jeunesse) beauftragt. Der vorliegende Evaluationsbericht ergänzt die im Auftrag der Europäischen Kommission parallel erfolgende externe Evaluierung und rückt die nationale luxemburgische Perspektive in den Fokus. Der Schwerpunkt der Evaluation liegt daher auf den Erfahrungen und Rückmeldungen der relevanten Akteure (Ministerium, Agenturen, Projektverantwortliche, Projektteilnehmer) bezüglich der Implementierung, Durchführung und Auswirkungen des Programms in Luxemburg. Deren Einschätzungen werden im Bericht dargestellt.

Published
2017

41. Der Übergang in Arbeit und seine Auswirkungen auf die gesellschaftliche Integration und das Erwachsenwerden. Transitionsverläufe, Probleme und Bewältigungsmuster von Jugendlichen und jungen Erwachsenen

Author

Weis, Daniel and Joachim, Patrice

Subjects
Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie], Sociology & social sciences [H10] [Social & behavioral sciences, psychology], transition youth to adulthood, becoming and being an adult, typology, coping strategies
Abstract

Im Beitrag werden eine Typologie von Transitionsverläufen und Bewältigungsmustern junger Menschen in Luxemburg sowie deren subjektive Perspektiven auf das Erwachsenwerden und Erwachsensein vorgestellt. Durch die typologische Einordnung auf Basis der individuellen Erfahrungen und Deutungen können Erfolgsfaktoren, Gelingensbedingungen und Hemmnisse für den Übergang ins Erwerbsleben identifiziert werden. Dabei zeigt sich, dass der Übergang in Arbeit zwar maßgeblich die gesellschaftliche Integration junger Menschen beeinflusst, das subjektive Gefühl des Erwachsenseins davon aber durchaus unabhängig sein kann.

Published
2017

42. Der Übergang in Arbeit und seine Auswirkungen auf die gesellschaftliche Integration und das Erwachsenwerden von Jugendlichen

Author

Joachim, Patrice and Weis, Daniel

Subjects
Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie], school-to-work transition, Sociology & social sciences [H10] [Social & behavioral sciences, psychology], transition youth to adulthood, integration
Abstract

Die Phase des Übergangs vom Jugend- zum Erwachsenenalter wird von gesellschaftlichen Normvorstellungen und entsprechenden Erwartungen begleitet. Aus entwicklungspsychologischer Perspektive werden den Jugendlichen bestimmte Entwicklungsaufgaben zugeschrieben, die in dieser Phase bewältigt werden sollen (Havighurst 1972). Darunter werden Anforderungen an das Individuum verstanden, deren Bewältigung zu einer erfolgreichen gesellschaftlichen Integration notwendig ist. Zu den Wesentlichen gehören die Ablösung vom Elternhaus, die Gründung einer eigenen Familie, die Aufnahme einer Erwerbstätigkeit und damit zusammenhängend eine ökonomische Unabhängigkeit (Hurrelmann 2009, Kerckhoff 2000, Merkens 2012). Im Widerspruch zu diesen Normen stehen die zu beobachtenden Tendenzen einer immer weniger normierten Transitionsgestaltung: Übergänge werden zunehmend individueller und verlaufen weniger einheitlich (Konietzka 2010). Diese Entwicklung führte in den vergangenen Jahren und Jahrzehnten zu einer Verlängerung der Jugendphase (Zinnecker 2003), einer Verlagerung von Transitionsmarkern auf einen späteren Zeitpunkt, einer Entkopplung von Transitionsereignissen sowie einer Diversität bzw. De-Standardisierung von Verläufen (Stauber/Walther 2004). Damit einhergehend ist die Phase des Übergangs mit geringerer Sicherheit und Planbarkeit sowie höherem Risiko für das Individuum verbunden. Dies betrifft insbesondere den Übergang junger Menschen in den Arbeitsmarkt, der im Fokus des Vortrags steht. Vorgestellt wird eine Typologie von Transitionsverläufen und Bewältigungsmustern junger Menschen in Luxemburg sowie deren subjektive Perspektiven auf das Erwachsenwerden und Erwachsensein. Durch die typologische Einordnung auf Basis der individuellen Erfahrungen und Deutungen können Erfolgsfaktoren, Gelingensbedingungen und Hemmnisse für den Übergang ins Erwerbsleben identifiziert werden. Dabei zeigt sich, dass Transitionsprobleme zu Maßnahmenkarrieren, Armut, sozialer Exklusion und gesundheitlichen bzw. psychischen Beeinträchtigungen führen können. Sie erschweren aber nicht nur die gesellschaftliche Integration, sondern haben darüber hinaus auch Einfluss auf das subjektive Gefühl des Erwachsenseins. Die Präsentation basiert auf den Ergebnissen einer qualitativen Befragung von 77 Jugendlichen und jungen Erwachsenen im Rahmen des luxemburgischen Jugendberichts 2015.

Published
2016

43. Nationaler Bericht zur Situation der Jugend in Luxemburg 2015. Gesellschaftliche und politische Beteiligung Jugendlicher

Author

Meyers, Christiane, Weis, Daniel, Ministère de l'Education nationale, de l'Enfance et de la Jeunesse [sponsor], and Integrative Research Unit: Social and Individual Development (INSIDE) > Institute for Research on Generations and Family [research center]

Subjects
youth, Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie], Sociology & social sciences [H10] [Social & behavioral sciences, psychology], participation
Published
2016

44. Crucial components in successfully mastering the transition into work – Patterns of coping

Author

Schumacher, Anette and Weis, Daniel

Subjects
coping, Sociologie & sciences sociales [H10] [Sciences sociales & comportementales, psychologie], transition into work, Luxembourg, Sociology & social sciences [H10] [Social & behavioral sciences, psychology]
Abstract

Research issue: Sociological and psychological theories (Hurrelmann & Quenzel, 2012; Havighurst, 1972) consider a successfully accomplishing of certain developmental task as master challenge of youth. Regarding the economic situation, the transition into work is nowadays a big issue for young people. As a result of social liberalisation and individualisation, developmental tasks and social roles can be more individually chosen and shaped, offering both advantages (more personal freedom) and disadvantages (greater personal responsibility, less strong orientation). How do the Luxembourgish youth of today handle the transition into work in the light of the above and what are the crucial components in successfully mastering the transition into work? Research questions: Our interests are related to the speed, the time and the degree of success of the transition and the coping strategies behind. In what way transition into work is influenced by gender, nationality/migration status and level of education? What are the varying processes, rationales and patterns for accomplishing the transition into work? And what is the role of support services for young people facing problems during the transition? Context and data: The research is based on various data sources. A secondary data analyses was used to a systematic description of young people differentiated by age, level of education and nationality/migration status with regard to transition markers. We devote particular attention to the participation of the young people themselves as experts in our research methods. 77 guideline-based interviews with young people were used to collect subjective information about their coping strategies to accomplish the transition into work. A standardized survey of participants in support services focused on their experiences and their learning outcomes was filled out by 1162 young persons. Experts from academia, professional practice, administration and politics together with representatives of young people participated in 11 focus group discussions. The triangulation of different methodical approaches and different data sources resulted in a broad and multi-perspective representation of young people’s transition into adulthood. Main results: 1) There is a big influence of the educational qualifications, the migration status and family support. For adolescents with average or high educational qualifications the transition into adulthood is easier (less frequently unemployed, find jobs matching their qualifications, more permanent employment contracts). Young people with poor school leaving qualifications face considerable difficulty with the transition into work. An analysis differentiating levels of education by migration background and nationality shows large differences. The data also demonstrates in particular the important supporting role played by the family (financial or emotional, acting as a role model, providing information or informal knowledge, or access to networks). 2) Furthermore our study identified widely varying processes, rationales and patterns for accomplishing the transition. Four types of transition could be identified (direct transition, alternative transition, transition requiring support and failed transition), distinguished by the different strategies for action, values, perspectives and attitudes. 3) The results of the survey indicate some subjective benefit of support service participation, but also potential for improvement.

Published
2016

46. Sclerostin deficiency modifies the development of CKD-MBD in mice

Author

Kaesler, Nadine, primary, Verhulst, Anja, additional, De Maré, Annelies, additional, Deck, Annika, additional, Behets, Geert J., additional, Hyusein, Ayshe, additional, Evenepoel, Pieter, additional, Floege, Jürgen, additional, Marx, Nikolaus, additional, Babler, Anne, additional, Kramer, Ina, additional, Kneissel, Michaela, additional, Kramann, Rafael, additional, Weis, Daniel, additional, D'Haese, Patrick C., additional, and Brandenburg, Vincent M., additional

Published
2018
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49. Midterm Evaluation Erasmus+. Evaluationsstudie zur Implementierung von Erasmus+ in Luxemburg

Author

Integrative Research Unit: Social and Individual Development (INSIDE) > Institute for Research on Generations and Family [research center], Ministère de l'Éducation nationale, de l'Enfance et de la Jeunesse [sponsor], Weis, Daniel, Meyers, Christiane, Willems, Helmut, Integrative Research Unit: Social and Individual Development (INSIDE) > Institute for Research on Generations and Family [research center], Ministère de l'Éducation nationale, de l'Enfance et de la Jeunesse [sponsor], Weis, Daniel, Meyers, Christiane, and Willems, Helmut

Abstract

Der vorliegende Bericht stellt die Ergebnisse der Zwischenevaluation über die Durchführung und die Wirkung des Programms Erasmus+ in Luxemburg vor. Mit der Durchführung der Evaluation und der Berichterstellung wurde die Jugendforschung der Universität Luxemburg unter Leitung von Prof. Dr. Helmut Willems vom zuständigen Ministerium (Ministère de l'Éducation nationale, de l'Enfance et de la Jeunesse) beauftragt. Der vorliegende Evaluationsbericht ergänzt die im Auftrag der Europäischen Kommission parallel erfolgende externe Evaluierung und rückt die nationale luxemburgische Perspektive in den Fokus. Der Schwerpunkt der Evaluation liegt daher auf den Erfahrungen und Rückmeldungen der relevanten Akteure (Ministerium, Agenturen, Projektverantwortliche, Projektteilnehmer) bezüglich der Implementierung, Durchführung und Auswirkungen des Programms in Luxemburg. Deren Einschätzungen werden im Bericht dargestellt.

Published
2017

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