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28 results on '"Welker, Christian"'

5. Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo

Author

Eckert, Franziska, primary, Jelas, Ivan, additional, Oehme, Moritz, additional, Huber, Stephan M., additional, Sonntag, Katja, additional, Welker, Christian, additional, Gillies, Stephen D., additional, Strittmatter, Wolfgang, additional, Zips, Daniel, additional, Handgretinger, Rupert, additional, and Schilbach, Karin, additional

Published
2017
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6. Human Peripheral CD4+ Vδ1+ γδT Cells Can Develop into αβT Cells

Author

Ziegler, Hendrik, Welker, Christian, Sterk, Marco, Haarer, Jan, Rammensee, Hans-Georg, Handgretinger, Rupert, and Schilbach, Karin

Subjects
δβ heterodimer, extrathymic T-cell development, inflammation, Immunology, extrathymic T-cell progenitor, hematopoietic progenitor cell, T-cell development, Original Research, Vδ1+ γδT cells
Abstract

The lifelong generation of αβT cells enables us to continuously build immunity against pathogens and malignancies despite the loss of thymic function with age. Homeostatic proliferation of post-thymic naïve and memory T cells and their transition into effector and long-lived memory cells balance the decreasing output of naïve T cells, and recent research suggests that also αβT-cell development independent from the thymus may occur. However, the sites and mechanisms of extrathymic T-cell development are not yet understood in detail. γδT cells represent a small fraction of the overall T-cell pool, and are endowed with tremendous phenotypic and functional plasticity. γδT cells that express the Vδ1 gene segment are a minor population in human peripheral blood but predominate in epithelial (and inflamed) tissues. Here, we characterize a CD4(+) peripheral Vδ1(+) γδT-cell subpopulation that expresses stem-cell and progenitor markers and is able to develop into functional αβT cells ex vivo in a simple culture system and in vivo. The route taken by this process resembles thymic T-cell development. However, it involves the re-organization of the Vδ1(+) γδTCR into the αβTCR as a consequence of TCR-γ chain downregulation and the expression of surface Vδ1(+)Vβ(+) TCR components, which we believe function as surrogate pre-TCR. This transdifferentiation process is readily detectable in vivo in inflamed tissue. Our study provides a conceptual framework for extrathymic T-cell development and opens up a new vista in immunology that requires adaptive immune responses in infection, autoimmunity, and cancer to be reconsidered.

Published
2014

9. Chronic graft-versus-host-disease in CD34+-humanized NSG mice is associated with human susceptibility HLA haplotypes for autoimmune disease

Author

Sonntag, Katja, primary, Eckert, Franziska, additional, Welker, Christian, additional, Müller, Hartmut, additional, Müller, Friederike, additional, Zips, Daniel, additional, Sipos, Bence, additional, Klein, Reinhild, additional, Blank, Gregor, additional, Feuchtinger, Tobias, additional, Schumm, Michael, additional, Handgretinger, Rupert, additional, and Schilbach, Karin, additional

Published
2015
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10. Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation

Author

Schilbach, Karin, primary, Alkhaled, Mohammed, additional, Welker, Christian, additional, Eckert, Franziska, additional, Blank, Gregor, additional, Ziegler, Hendrik, additional, Sterk, Marco, additional, Müller, Friederike, additional, Sonntag, Katja, additional, Wieder, Thomas, additional, Braumüller, Heidi, additional, Schmitt, Julia, additional, Eyrich, Matthias, additional, Schleicher, Sabine, additional, Seitz, Christian, additional, Erbacher, Annika, additional, Pichler, Bernd J, additional, Müller, Hartmut, additional, Tighe, Robert, additional, Lim, Annick, additional, Gillies, Stephen D, additional, Strittmatter, Wolfgang, additional, Röcken, Martin, additional, and Handgretinger, Rupert, additional

Published
2015
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12. Human peripheral CD4+ Vδ1+ γδT cells can develop into αβT cells.

Author

Ziegler, Hendrik, Welker, Christian, Sterk, Marco, Haarer, Jan, Rammensee, Hans-Georg, Handgretinger, Rupert, Schilbach, Karin, Schönbach, Christian, and Kaye, Jonathan

Subjects
T cells, HOMEOSTASIS, IMMUNE response, THYMUS, PROGENITOR cells
Abstract

The lifelong generation of αβT cells enables us to continuously build immunity against pathogens and malignancies despite the loss of thymic function with age. Homeostatic proliferation of post-thymic naïve and memory T cells and their transition into effector and long-lived memory cells balance the decreasing output of naïveT cells, and recent research suggests that also αβT-cell development independent from the thymus may occur. However, the sites and mechanisms of extrathymic T-cell development are not yet understood in detail. γδT cells represent a small fraction of the overall T-cell pool, and are endowed with tremendous phenotypic and functional plasticity. γδT cells that express the Vδ1 gene segment are a minor population in human peripheral blood but predominate in epithelial (and inflamed) tissues. Here, we characterize a CD4+ peripheral Vδ1+ γδT-cell subpopulation that expresses stem-cell and progenitor markers and is able to develop into functional abT cells ex vivo in a simple culture system and in vivo. The route taken by this process resembles thymic T-cell development. However, it involves the re-organization of the Vδ1+ γδTCR into the abTCR as a consequence ofTCR-γ chain downregulation and the expression of surfaceVδ1+Vβ+TCR components, whichwe believe function as surrogate pre-TCR.This transdifferentiation process is readily detectable in vivo in inflamed tissue. Our study provides a conceptual framework for extrathymicT-cell development and opens up a new vista in immunology that requires adaptive immune responses in infection, autoimmunity, and cancer to be reconsidered. [ABSTRACT FROM AUTHOR]

Published
2014
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23. Ethologische Bedeutung des Harnwaschens von Galago crassicaudatusE. Geoffroy, 1812 (Lorisiformes: Galagidae)

Author

Welker, Christian

Abstract

The frequency of urine-washing depends on temperature, atmospheric moisture and substrate conditions. The function of this behaviour is an additional moistening of the volar surfaces. By this habit, the tactile integument of hands and feet will get their special capacity. No indications, however, could be found to verify the theory of olfactory marking of traces. The activity of the animals is given as well in each experiment.

Published
1973
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