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20 results on '"Weller, Melodie L."'

4. Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses

Author

Maximova, Olga A., primary, Weller, Melodie L., additional, Krogmann, Tammy, additional, Sturdevant, Daniel E., additional, Ricklefs, Stacy, additional, Virtaneva, Kimmo, additional, Martens, Craig, additional, Wollenberg, Kurt, additional, Minai, Mahnaz, additional, Moore, Ian N., additional, Sauter, Craig S., additional, Barker, Juliet N., additional, Lipkin, W. Ian, additional, Seilhean, Danielle, additional, Nath, Avindra, additional, and Cohen, Jeffrey I., additional

Published
2023
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9. Imbalanced immune response and dysregulation of neural functions underline fatal opportunistic encephalitis caused by astrovirus

Author

Maximova, Olga A., primary, Weller, Melodie L., additional, Krogmann, Tammy, additional, Sturdevant, Daniel E., additional, Ricklefs, Stacy, additional, Virtaneva, Kimmo, additional, Martens, Craig, additional, Wollenberg, Kurt, additional, Minai, Mahnaz, additional, Moore, Ian N., additional, Sauter, Craig S., additional, Barker, Juliet N., additional, Lipkin, W. Ian, additional, Seilhean, Danielle, additional, Nath, Avindra, additional, and Cohen, Jeffrey I., additional

Published
2022
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13. Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6

Author

Weller, Melodie L., Amornphimoltham, Panomwat, Schmidt, Michael, Wilson, Paul A., Gutkind, J. Silvio, and Chiorini, John A.

Subjects
Gene therapy -- Health aspects -- Research -- Usage -- Physiological aspects, Transduction -- Research -- Health aspects -- Physiological aspects -- Genetic aspects -- Usage, Growth factor receptors -- Physiological aspects -- Genetic aspects -- Research -- Health aspects -- Usage, Adenoviruses -- Usage -- Genetic aspects -- Research -- Physiological aspects -- Health aspects
Abstract

A key step in gene therapy is the efficient transfer of genes in a cell type--and tissue-specific manner. To better understand the mechanism of adeno-associated virus serotype 6 (AAV6) transduction, we used comparative gene analysis (CGA) combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression. Subsequent experiments suggested that EGFR is necessary for vector internalization and probably functions as a co-receptor for AAV6., AAV vectors offer unique advantages over other vector systems in gene therapy applications. Several studies have shown that these replication-deficient parvovirus vectors can deliver DNA to specific tissues and confer [...]

Published
2010
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14. Hepatitis Delta Virus Detected in Salivary Glands of Sjögren’s Syndrome Patients and Recapitulates a Sjögren’s Syndrome-Like Phenotype in Vivo

Author

Weller, Melodie L., primary, Gardener, Matthew R., additional, Bogus, Zoe C., additional, Smith, Michael A., additional, Astorri, Elisa, additional, Michael, Drew G., additional, Michael, Donald A., additional, Zheng, Changyu, additional, Burbelo, Peter D., additional, Lai, Zhennan, additional, Wilson, Paul A., additional, Swaim, William, additional, Handelman, Beverly, additional, Afione, Sandra A., additional, Bombardieri, Michele, additional, and Chiorini, John A., additional

Published
2016
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18. Rho GTPases Modulate Entry of Ebola Virus and Vesicular Stomatitis Virus Pseudotyped Vectors

Author

Quinn, Kathrina, primary, Brindley, Melinda A., additional, Weller, Melodie L., additional, Kaludov, Nikola, additional, Kondratowicz, Andrew, additional, Hunt, Catherine L., additional, Sinn, Patrick L., additional, McCray, Paul B., additional, Stein, Colleen S., additional, Davidson, Beverly L., additional, Flick, Ramon, additional, Mandell, Robert, additional, Staplin, William, additional, Maury, Wendy, additional, and Chiorini, John A., additional

Published
2009
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20. Growing Awareness: Limited Testing and Screening Bias for Hepatitis Delta Virus in Utah 2000-2021.

Author

Hesterman MC, Fallon BS, Lynch KM, and Weller ML

Abstract

Background: This study assessed the epidemiology of hepatitis delta virus (HDV) within the University of Utah UHealth health care system (2000-2021)., Methods: Analysis of HDV/HBV testing, diagnostic codes, liver enzymes, and comorbidities was performed., Results: Among the 1962 HBV patients, only 22.2% underwent HDV testing, revealing an 8.3% positivity rate for HDV coinfections. This study observed a consistent increase in HBV and HDV cases, with higher HDV detection rates linked to increased testing. Limited HDV testing and potential screening biases were evident., Discussion: Improved HDV testing and surveillance are crucial for early detection and implementation of targeted therapies., Competing Interests: Potential conflicts of interest. M. L. W. and K. M. L. have current funding from Gilead Sciences, Inc. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)

Published
2024
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