351 results on '"Welling J."'
Search Results
2. From bacterial isolates to antibiotic resistograms ‒ towards an automated detection of recently acquired antibiotic resistance genes (ARGs) using machine learning
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Welling, J, Imangaliyev, S, Magin, S, Kehrmann, J, Kraiselburd, I, Meyer, F, Welling, J, Imangaliyev, S, Magin, S, Kehrmann, J, Kraiselburd, I, and Meyer, F
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- 2023
3. Randomized feasibility trial of the Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program.
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Kwakkenbos, L, Østbø, N, Carrier, M-E, Nielson, WR, Fedoruk, C, Levis, B, Henry, RS, Pope, J, Frech, T, Gholizadeh, S, Johnson, SR, Piotrowski, P, Jewett, LR, Gordon, J, Chung, L, Bilsker, D, Tao, L, Turner, KA, Cumin, J, Welling, J, Fortuné, C, Leite, C, Gottesman, K, Sauvé, M, Reyna, TSR, Hudson, M, Larche, M, van Breda, W, Suarez-Almazor, ME, Bartlett, SJ, Malcarne, VL, Mayes, MD, Boutron, I, Mouthon, L, Benedetti, A, Thombs, BD, SPIN Investigators, Kwakkenbos, L, Østbø, N, Carrier, M-E, Nielson, WR, Fedoruk, C, Levis, B, Henry, RS, Pope, J, Frech, T, Gholizadeh, S, Johnson, SR, Piotrowski, P, Jewett, LR, Gordon, J, Chung, L, Bilsker, D, Tao, L, Turner, KA, Cumin, J, Welling, J, Fortuné, C, Leite, C, Gottesman, K, Sauvé, M, Reyna, TSR, Hudson, M, Larche, M, van Breda, W, Suarez-Almazor, ME, Bartlett, SJ, Malcarne, VL, Mayes, MD, Boutron, I, Mouthon, L, Benedetti, A, Thombs, BD, and SPIN Investigators
- Abstract
BACKGROUND: The Scleroderma Patient-centered Intervention Network (SPIN) developed an online self-management program (SPIN-SELF) designed to improve disease-management self-efficacy in people with systemic sclerosis (SSc, or scleroderma). The aim of this study was to evaluate feasibility aspects for conducting a full-scale randomized controlled trial (RCT) of the SPIN-SELF Program. METHODS: This feasibility trial was embedded in the SPIN Cohort and utilized the cohort multiple RCT design. In this design, at the time of cohort enrollment, cohort participants consent to be assessed for trial eligibility and randomized prior to being informed about the trial. Participants in the intervention arm are informed and provide consent, but not the control group. Forty English-speaking SPIN Cohort participants from Canada, the USA, or the UK with low disease-management self-efficacy (Self-Efficacy for Managing Chronic Disease Scale [SEMCD] score ≤ 7) who were interested in using an online self-management program were randomized (3:2 ratio) to be offered the SPIN-SELF Program or usual care for 3 months. Program usage was examined via automated usage logs. User satisfaction was assessed with semi-structured interviews. Trial personnel time requirements and implementation challenges were logged. RESULTS: Of 40 SPIN Cohort participants randomized, 26 were allocated to SPIN-SELF and 14 to usual care. Automated eligibility and randomization procedures via the SPIN Cohort platform functioned properly, except that two participants with SEMCD scores > 7 (scores of 7.2 and 7.3, respectively) were included, which was caused by a system programming error that rounded SEMCD scores. Of 26 SPIN Cohort participants offered the SPIN-SELF Program, only 9 (35%) consented to use the program. Usage logs showed that use of the SPIN-SELF Program was low: 2 of 9 users (22%) logged into the program only once (median = 3), and 4 of 9 (44%) accessed none or only 1 of the 9 program's modules (median = 2)
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- 2022
4. Randomized controlled trial of an internet-based self-guided hand exercise program to improve hand function in people with systemic sclerosis: the Scleroderma Patient-centered Intervention Network Hand Exercise Program (SPIN-HAND) trial.
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Kwakkenbos, L, Carrier, M-E, Welling, J, Levis, B, Levis, AW, Sauve, M, Turner, KA, Tao, L, Aguila, K, Carboni-Jiménez, A, Cañedo-Ayala, M, Harb, S, van den Ende, C, Hudson, M, van Breda, W, Nguyen, C, Boutron, I, Rannou, F, Thombs, BD, Mouthon, L, SPIN Investigators, Kwakkenbos, L, Carrier, M-E, Welling, J, Levis, B, Levis, AW, Sauve, M, Turner, KA, Tao, L, Aguila, K, Carboni-Jiménez, A, Cañedo-Ayala, M, Harb, S, van den Ende, C, Hudson, M, van Breda, W, Nguyen, C, Boutron, I, Rannou, F, Thombs, BD, Mouthon, L, and SPIN Investigators
- Abstract
BACKGROUND: Systemic sclerosis (scleroderma; SSc) is a rare autoimmune connective tissue disease. Functional impairment of hands is common. The Scleroderma Patient-centered Intervention Network (SPIN)-HAND trial compared effects of offering access to an online self-guided hand exercise program to usual care on hand function (primary) and functional health outcomes (secondary) in people with SSc with at least mild hand function limitations. METHODS: The pragmatic, two-arm, parallel-group cohort multiple randomized controlled trial was embedded in the SPIN Cohort. Cohort participants with Cochin Hand Function Scale (CHFS) scores ≥ 3 and who indicated interest in using the SPIN-HAND Program were randomized (3:2 ratio) to an offer of program access or to usual care (targeted N = 586). The SPIN-HAND program consists of 4 modules that address (1) thumb flexibility and strength; (2) finger bending; (3) finger extension; and (4) wrist flexibility and strength. The primary outcome analysis compared CHFS scores 3 months post-randomization between participants offered versus not offered the program. Secondary outcomes were CHFS scores 6 months post-randomization and functional health outcomes (Patient-Reported Outcomes Measurement Information System profile version 2.0 domain scores) 3 and 6 months post-randomization. RESULTS: In total, 466 participants were randomized to intervention offer (N = 280) or usual care (N = 186). Of 280 participants offered the intervention, 170 (61%) consented to access the program. Of these, 117 (69%) viewed at least one hand exercise instruction video and 77 (45%) logged into the program website at least 3 times. In intent-to-treat analyses, CHFS scores were 1.2 points lower (95% CI - 2.8 to 0.3) for intervention compared to usual care 3 months post-randomization and 0.1 points lower (95% CI - 1.8 to 1.6 points) 6 months post-randomization. There were no statistically significant differences in other outcomes. CONCLUSION: The offer to use the SP
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- 2022
5. Excitotoxicity as a Common Mechanism for Fetal Neuronal Injury with Hypoxia and Intrauterine Inflammation
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Burd, I., primary, Welling, J., additional, Kannan, G., additional, and Johnston, M.V., additional
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- 2016
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6. External and internal challenges of glacier tourism development in Iceland.
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Welling, J., primary and Árnason, T., additional
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- 2016
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7. Non-governmental Organizations, Prevention, and Intervention in Internal Conflict: Though the Lens of Darfur
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Welling, J. J.
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- 2007
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8. POS1497-PARE POST-TRIAL SURVEY OF PARTICIPANTS OF A PHASE 3 CLINICAL TRIAL IN SSC-ILD
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Galetti, I., primary, Brown, E., additional, Kennedy, A., additional, Riggs, R. J., additional, Roennow, A., additional, Sauvé, M., additional, Welling, J., additional, Finnern, H., additional, Gilbert, A., additional, Gahlemann, M., additional, and Sauter, W., additional
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- 2021
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9. Identifying unmet needs in SSc-ILD by semi-qualitative in-depth interviews
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Hoffmann-Vold, A.M., Bendstrup, E., Dimitroulas, T., Hesselstrand, R., Morais, A., Peltomaa, R., Smith, V., Welling, J., Vonk, M.C., Wuyts, W.A., Hoffmann-Vold, A.M., Bendstrup, E., Dimitroulas, T., Hesselstrand, R., Morais, A., Peltomaa, R., Smith, V., Welling, J., Vonk, M.C., and Wuyts, W.A.
- Abstract
Item does not contain fulltext, OBJECTIVES: Interstitial lung disease is frequent in SSc (SSc-ILD) and associates with significantly reduced quality of life. Here we aimed to analyse patient pathways, and experiences of patients and healthcare providers (HCPs) in order to identify unmet needs in the management of SSc-ILD patients. METHODS: Semi-structured qualitative interviews conducted in eight European countries looked at HCP (n = 95) and patient perspectives (n = 47) using two sets of 70 research questions. Pre-diagnostic, diagnostic and post-diagnostic phases of the patient pathway were systematically explored. RESULTS: (i) In the pre-diagnostic phase several gaps were identified by HCPs and patients in all participating countries: limited disease knowledge among primary care physicians and specialists, lack of accurate patient information, and delayed and/or inappropriate referral. (ii) The diagnostic phase is in most countries coordinated by rheumatologists, who are also the main point of care. Depending on the local health system, organization of multidisciplinary collaboration varies. HCPs issued lack of national guidelines, while patients stated difficulties obtaining disease-related information. (iii) In the post-diagnostic phase, HCPs and patients indicated lack of curative treatment, specialized nurses, and paramedical and psychological support. Patients and caregivers additionally expressed the need for clear information on SSc-ILD. CONCLUSION: Lack of disease specific knowledge, gaps in national healthcare systems and insufficient information and support for patients and caregivers were identified as unmet needs to ensure timely diagnosis, provide better patient management and to improve quality of life in SSc-ILD patients.
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- 2021
10. The Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program: protocol for a two-arm parallel partially nested randomized controlled feasibility trial with progression to full-scale trial.
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Nordlund, J, Henry, RS, Kwakkenbos, L, Carrier, M-E, Levis, B, Nielson, WR, Bartlett, SJ, Dyas, L, Tao, L, Fedoruk, C, Nielsen, K, Hudson, M, Pope, J, Frech, T, Gholizadeh, S, Johnson, SR, Piotrowski, P, Jewett, LR, Gordon, J, Chung, L, Bilsker, D, Levis, AW, Turner, KA, Cumin, J, Welling, J, Fortuné, C, Leite, C, Gottesman, K, Sauve, M, Rodríguez-Reyna, TS, Larche, M, van Breda, W, Suarez-Almazor, ME, Wurz, A, Culos-Reed, N, Malcarne, VL, Mayes, MD, Boutron, I, Mouthon, L, Benedetti, A, Thombs, BD, SPIN Investigators, Nordlund, J, Henry, RS, Kwakkenbos, L, Carrier, M-E, Levis, B, Nielson, WR, Bartlett, SJ, Dyas, L, Tao, L, Fedoruk, C, Nielsen, K, Hudson, M, Pope, J, Frech, T, Gholizadeh, S, Johnson, SR, Piotrowski, P, Jewett, LR, Gordon, J, Chung, L, Bilsker, D, Levis, AW, Turner, KA, Cumin, J, Welling, J, Fortuné, C, Leite, C, Gottesman, K, Sauve, M, Rodríguez-Reyna, TS, Larche, M, van Breda, W, Suarez-Almazor, ME, Wurz, A, Culos-Reed, N, Malcarne, VL, Mayes, MD, Boutron, I, Mouthon, L, Benedetti, A, Thombs, BD, and SPIN Investigators
- Abstract
BACKGROUND: Systemic sclerosis (scleroderma; SSc) is a rare autoimmune connective tissue disease. We completed an initial feasibility trial of an online self-administered version of the Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program using the cohort multiple randomized controlled trial (RCT) design. Due to low intervention offer uptake, we will conduct a new feasibility trial with progression to full-scale trial, using a two-arm parallel, partially nested RCT design. The SPIN-SELF Program has also been revised to include facilitator-led videoconference group sessions in addition to online material. We will test the group-based intervention delivery format, then evaluate the effect of the SPIN-SELF Program on disease management self-efficacy (primary) and patient activation, social appearance anxiety, and functional health outcomes (secondary). METHODS: This study is a feasibility trial with progression to full-scale RCT, pending meeting pre-defined criteria, of the SPIN-SELF Program. Participants will be recruited from the ongoing SPIN Cohort ( http://www.spinsclero.com/en/cohort ) and via social media and partner patient organizations. Eligible participants must have SSc and low to moderate disease management self-efficacy (Self-Efficacy for Managing Chronic Disease (SEMCD) Scale score ≤ 7.0). Participants will be randomized (1:1 allocation) to the group-based SPIN-SELF Program or usual care for 3 months. The primary outcome in the full-scale trial will be disease management self-efficacy based on SEMCD Scale scores at 3 months post-randomization. Secondary outcomes include SEMCD scores 6 months post-randomization plus patient activation, social appearance anxiety, and functional health outcomes at 3 and 6 months post-randomization. We will include 40 participants to assess feasibility. At the end of the feasibility portion, stoppage criteria will be used to determine if the trial procedures or SPIN-SELF Program need important
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- 2021
11. Comparison of foam core materials in innovative lightweight wood-based panels
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Shalbafan, A., Luedtke, J., Welling, J., and Thoemen, H.
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- 2012
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12. Protocol for a partially nested randomised controlled trial to evaluate the effectiveness of the scleroderma patient-centered intervention network COVID-19 home-isolation activities together (SPIN-CHAT) program to reduce anxiety among at-risk scleroderma patients
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Thombs, B.D., Kwakkenbos, L., Carrier, M.E., Bourgeault, A., Tao, L.D., Harb, S., Gagarine, M., Rice, D., Bustamante, L., Ellis, K., Duchek, D., Wu, Y., Bhandari, P.M., Neupane, D., Carboni-Jimenez, A., Henry, R.S., Krishnan, A., Sun, Y., Levis, B., He, C., Turner, K.A., Benedetti, A., Culos-Reed, N., El-Baalbaki, G., Hebblethwaite, S., Bartlett, S.J., Dyas, L., Patten, S., Varga, J., Fortune, C., Gietzen, A., Guillot, G., Lewis, N., Nielsen, K., Richard, M., Sauve, M., Welling, J., Baron, M., Furst, D.E., Gottesman, K., Malcarne, V., Mayes, M.D., Mouthon, L., Nielson, W.R., Riggs, R., Wigley, F., Assassi, S., Boutron, I., Ells, C., Ende, C. van den, Fligelstone, K., Frech, T., Godard, D., Harel, D., Hinchcliff, M., Hudson, M., Johnson, S.R., Larche, M., Leite, C., Nguyen, C., Pope, J., Portales, A., Rannou, F., Reyna, T.S.R., Schouffoer, A.A., Suarez-Almazor, M.E., Agard, C., Albert, A., Andre, M., Arsenault, G., Benzidia, I., Bernstein, E.J., Berthier, S., Bissonnette, L., Boire, G., Bruns, A., Carreira, P., Casadevall, M., Chaigne, B., Chung, L., Cohen, P., Correia, C., Dagenais, P., Denton, C., Domsic, R., Dubois, S., Dunne, J.V., Dunogue, B., Fare, R., Farge-Bancel, D., Fortin, P.R., Gill, A., Gordon, J., Granel-Rey, B., Gyger, G., Hachulla, E., Hatron, P.Y., Herrick, A.L., Hij, A., Hoa, S., Ikic, A., Jones, N., Fernandes, A.J.D., Kafaja, S., Khalidi, N., Lambert, M., Launay, D., Liang, P., Maillard, H., Maltez, N., Manning, J., Marie, I., Martin, M., Martin, T., Masetto, A., Maurier, F., Mekinian, A., Melchor, S., Nikpour, M., Olagne, L., Poindron, V., Proudman, S., Regent, A., Riviere, S., Robinson, D., Rodriguez, E., Roux, S., Smets, P., Smith, D., Sobanski, V., Spiera, R., Steen, V., Stevens, W., Sutton, E., Terrier, B., Thorne, C., Wilcox, P., Ayala, M.C., Ostbo, N., Scleroderma Patient-ctr Interventi, and SPIN Investigators
- Subjects
Coronavirus ,COVID-19 ,Systemic sclerosis ,Mental health ,Anxiety ,RCT ,Trial ,Scleroderma - Abstract
Objective: Contagious disease outbreaks and related restrictions can lead to negative psychological outcomes, particularly in vulnerable populations at risk due to pre-existing medical conditions. No randomised controlled trials (RCTs) have tested interventions to reduce mental health consequences of contagious disease outbreaks. The primary objective of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Together (SPIN-CHAT) Trial is to evaluate the effect of a videoconference-based program on symptoms of anxiety. Secondary objectives include evaluating effects on symptoms of depression, stress, loneliness, boredom, physical activity, and social interaction.Methods: The SPIN-CHAT Trial is a pragmatic RCT that will be conducted using the SPIN-COVID-19 Cohort, a sub-cohort of the SPIN Cohort. Eligible participants will be SPIN-COVID-19 Cohort participants without a positive COVID-19 test, with at least mild anxiety (PROMIS Anxiety 4a v1.0 T-score >= 55), not working from home, and not receiving current counselling or psychotherapy. We will randomly assign 162 participants to intervention groups of 7 to 10 participants each or waitlist control. We will use a partially nested RCT design to reflect dependence between individuals in training groups but not in the waitlist control. The SPIN-CHAT Program includes activity engagement, education on strategies to support mental health, and mutual participant support. Intervention participants will receive the 4-week (3 sessions per week) SPIN-CHAT Program via video-conference. The primary outcome is PROMIS Anxiety 4a score immediately post-intervention.Ethics and dissemination: The SPIN-CHAT Trial will test whether a brief videoconference-based intervention will improve mental health outcomes among at-risk individuals during contagious disease outbreak.
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- 2020
13. Protocol for a partially nested randomised controlled trial to evaluate the effectiveness of the scleroderma patient-centered intervention network COVID-19 home-isolation activities together (SPIN-CHAT) program to reduce anxiety among at-risk scleroderma patients
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Thombs, BD, Kwakkenbos, L, Carrier, M-E, Bourgeault, A, Tao, L, Harb, S, Gagarine, M, Rice, D, Bustamante, L, Ellis, K, Duchek, D, Wu, Y, Bhandari, PM, Neupane, D, Carboni-Jimenez, A, Henry, RS, Krishnan, A, Sun, Y, Levis, B, He, C, Turner, KA, Benedetti, A, Culos-Reed, N, El-Baalbaki, G, Hebblethwaite, S, Bartlett, SJ, Dyas, L, Patten, S, Varga, J, Fortune, C, Gietzen, A, Guillot, G, Lewis, N, Nielsen, K, Richard, M, Sauve, M, Welling, J, Baron, M, Furst, DE, Gottesman, K, Malcarne, V, Mayes, MD, Mouthon, L, Nielson, WR, Riggs, R, Wigley, F, Assassi, S, Boutron, I, Ells, C, van den Ende, C, Fligelstone, K, Frech, T, Godard, D, Harel, D, Hinchcliff, M, Hudson, M, Johnson, SR, Larche, M, Leite, C, Nguyen, C, Pope, J, Portales, A, Rannou, F, Rodriguez Reyna, TS, Schouffoer, AA, Suarez-Almazor, ME, Agard, C, Albert, A, Andre, M, Arsenault, G, Benzidia, I, Bernstein, EJ, Berthier, S, Bissonnette, L, Boire, G, Bruns, A, Carreira, P, Casadevall, M, Chaigne, B, Chung, L, Cohen, P, Correia, C, Dagenais, P, Denton, C, Domsic, R, Dubois, S, Dunne, J, Dunogue, B, Fare, R, Farge-Bancel, D, Fortin, PR, Gill, A, Gordon, J, Granel-Rey, B, Gyger, G, Hachulla, E, Hatron, P-Y, Herrick, AL, Hij, A, Hoa, S, Ikic, A, Jones, N, Fernandes, AJDB, Kafaja, S, Khalidi, N, Lambert, M, Launay, D, Liang, P, Maillard, H, Maltez, N, Manning, J, Marie, I, Martin, M, Martin, T, Masetto, A, Maurier, F, Mekinian, A, Melchor, S, Nikpour, M, Olagne, L, Poindron, V, Proudman, S, Regent, A, Riviere, S, Robinson, D, Rodriguez, E, Roux, S, Smets, P, Smith, D, Sobanski, V, Spiera, R, Steen, V, Stevens, W, Sutton, E, Terrier, B, Thorne, C, Wilcox, P, Ayala, MC, Ostbo, N, Thombs, BD, Kwakkenbos, L, Carrier, M-E, Bourgeault, A, Tao, L, Harb, S, Gagarine, M, Rice, D, Bustamante, L, Ellis, K, Duchek, D, Wu, Y, Bhandari, PM, Neupane, D, Carboni-Jimenez, A, Henry, RS, Krishnan, A, Sun, Y, Levis, B, He, C, Turner, KA, Benedetti, A, Culos-Reed, N, El-Baalbaki, G, Hebblethwaite, S, Bartlett, SJ, Dyas, L, Patten, S, Varga, J, Fortune, C, Gietzen, A, Guillot, G, Lewis, N, Nielsen, K, Richard, M, Sauve, M, Welling, J, Baron, M, Furst, DE, Gottesman, K, Malcarne, V, Mayes, MD, Mouthon, L, Nielson, WR, Riggs, R, Wigley, F, Assassi, S, Boutron, I, Ells, C, van den Ende, C, Fligelstone, K, Frech, T, Godard, D, Harel, D, Hinchcliff, M, Hudson, M, Johnson, SR, Larche, M, Leite, C, Nguyen, C, Pope, J, Portales, A, Rannou, F, Rodriguez Reyna, TS, Schouffoer, AA, Suarez-Almazor, ME, Agard, C, Albert, A, Andre, M, Arsenault, G, Benzidia, I, Bernstein, EJ, Berthier, S, Bissonnette, L, Boire, G, Bruns, A, Carreira, P, Casadevall, M, Chaigne, B, Chung, L, Cohen, P, Correia, C, Dagenais, P, Denton, C, Domsic, R, Dubois, S, Dunne, J, Dunogue, B, Fare, R, Farge-Bancel, D, Fortin, PR, Gill, A, Gordon, J, Granel-Rey, B, Gyger, G, Hachulla, E, Hatron, P-Y, Herrick, AL, Hij, A, Hoa, S, Ikic, A, Jones, N, Fernandes, AJDB, Kafaja, S, Khalidi, N, Lambert, M, Launay, D, Liang, P, Maillard, H, Maltez, N, Manning, J, Marie, I, Martin, M, Martin, T, Masetto, A, Maurier, F, Mekinian, A, Melchor, S, Nikpour, M, Olagne, L, Poindron, V, Proudman, S, Regent, A, Riviere, S, Robinson, D, Rodriguez, E, Roux, S, Smets, P, Smith, D, Sobanski, V, Spiera, R, Steen, V, Stevens, W, Sutton, E, Terrier, B, Thorne, C, Wilcox, P, Ayala, MC, and Ostbo, N
- Abstract
Objective Contagious disease outbreaks and related restrictions can lead to negative psychological outcomes, particularly in vulnerable populations at risk due to pre-existing medical conditions. No randomised controlled trials (RCTs) have tested interventions to reduce mental health consequences of contagious disease outbreaks. The primary objective of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Together (SPIN-CHAT) Trial is to evaluate the effect of a videoconference-based program on symptoms of anxiety. Secondary objectives include evaluating effects on symptoms of depression, stress, loneliness, boredom, physical activity, and social interaction.
- Published
- 2020
14. Changes in mental health symptoms from pre-COVID-19 to COVID-19 among participants with systemic sclerosis from four countries: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort study
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Thombs, BD, Kwakkenbos, L, Henry, RS, Carrier, M-E, Patten, S, Harb, S, Bourgeault, A, Tao, L, Bartlett, SJ, Mouthon, L, Varga, J, Benedetti, A, Fortune, C, Gietzen, A, Guillot, G, Lewis, N, Richard, M, Sauve, M, Welling, J, Fligelstone, K, Gottesman, K, Leite, C, Perez, E, Baron, M, Malcarne, V, Mayes, MD, Nielson, WR, Riggs, R, Assassi, S, Ells, C, van den Ende, C, Frech, T, Harel, D, Hinchcliff, M, Hudson, M, Johnson, SR, Larche, M, Nguyen, C, Pope, J, Rannou, F, Reyna, TSR, Schouffoer, AA, Suarez-Almazor, ME, Agard, C, Albert, A, Bernstein, EJ, Berthier, S, Bissonnette, L, Bruns, A, Carreira, P, Chaigne, B, Chung, L, Correia, C, Denton, C, Domsic, R, Dunne, J, Dunogue, B, Farge-Bancel, D, Fortin, PR, Gordon, J, Granel-Rey, B, Hatron, P-Y, Herrick, AL, Hoa, S, Jones, N, Fernandes, AJDB, Kafaja, S, Khalidi, N, Launay, D, Manning, J, Marie, I, Martin, M, Mekinian, A, Melchor, S, Nikpour, M, Olagne, L, Proudman, S, Regent, A, Riviere, S, Robinson, D, Rodriguez, E, Roux, S, Sobanski, V, Steen, V, Sutton, E, Thorne, C, Wilcox, P, Ayala, MC, Carboni-Jimenez, A, Gagarine, M, Nordlund, J, Ostbo, N, Rice, DB, Turner, KA, Culos-Reed, N, Dyas, L, El-Baalbaki, G, Hebblethwaite, S, Bustamante, L, Duchek, D, Ellis, K, Thombs, BD, Kwakkenbos, L, Henry, RS, Carrier, M-E, Patten, S, Harb, S, Bourgeault, A, Tao, L, Bartlett, SJ, Mouthon, L, Varga, J, Benedetti, A, Fortune, C, Gietzen, A, Guillot, G, Lewis, N, Richard, M, Sauve, M, Welling, J, Fligelstone, K, Gottesman, K, Leite, C, Perez, E, Baron, M, Malcarne, V, Mayes, MD, Nielson, WR, Riggs, R, Assassi, S, Ells, C, van den Ende, C, Frech, T, Harel, D, Hinchcliff, M, Hudson, M, Johnson, SR, Larche, M, Nguyen, C, Pope, J, Rannou, F, Reyna, TSR, Schouffoer, AA, Suarez-Almazor, ME, Agard, C, Albert, A, Bernstein, EJ, Berthier, S, Bissonnette, L, Bruns, A, Carreira, P, Chaigne, B, Chung, L, Correia, C, Denton, C, Domsic, R, Dunne, J, Dunogue, B, Farge-Bancel, D, Fortin, PR, Gordon, J, Granel-Rey, B, Hatron, P-Y, Herrick, AL, Hoa, S, Jones, N, Fernandes, AJDB, Kafaja, S, Khalidi, N, Launay, D, Manning, J, Marie, I, Martin, M, Mekinian, A, Melchor, S, Nikpour, M, Olagne, L, Proudman, S, Regent, A, Riviere, S, Robinson, D, Rodriguez, E, Roux, S, Sobanski, V, Steen, V, Sutton, E, Thorne, C, Wilcox, P, Ayala, MC, Carboni-Jimenez, A, Gagarine, M, Nordlund, J, Ostbo, N, Rice, DB, Turner, KA, Culos-Reed, N, Dyas, L, El-Baalbaki, G, Hebblethwaite, S, Bustamante, L, Duchek, D, and Ellis, K
- Abstract
INTRODUCTION: No studies have reported mental health symptom comparisons prior to and during COVID-19 in vulnerable medical populations. OBJECTIVE: To compare anxiety and depression symptoms among people with a pre-existing medical condition and factors associated with changes. METHODS: Pre-COVID-19 Scleroderma Patient-centered Intervention Network Cohort data were linked to COVID-19 data from April 2020. Multiple linear and logistic regression were used to assess factors associated with continuous change and ≥ 1 minimal clinically important difference (MCID) change for anxiety (PROMIS Anxiety 4a v1.0; MCID = 4.0) and depression (Patient Health Questionnaire-8; MCID = 3.0) symptoms, controlling for pre-COVID-19 levels. RESULTS: Mean anxiety symptoms increased 4.9 points (95% confidence interval [CI] 4.0 to 5.7). Depression symptom change was negligible (0.3 points; 95% CI -0.7 to 0.2). Compared to France (N = 159), adjusted anxiety symptom change scores were significantly higher in the United Kingdom (N = 50; 3.3 points, 95% CI 0.9 to 5.6), United States (N = 128; 2.5 points, 95% CI 0.7 to 4.2), and Canada (N = 98; 1.9 points, 95% CI 0.1 to 3.8). Odds of ≥1 MCID increase were 2.6 for the United Kingdom (95% CI 1.2 to 5.7) but not significant for the United States (1.6, 95% CI 0.9 to 2.9) or Canada (1.4, 95% CI 0.7 to 2.5). Older age and adequate financial resources were associated with less continuous anxiety increase. Employment and shorter time since diagnosis were associated with lower odds of a ≥ 1 MCID increase. CONCLUSIONS: Anxiety symptoms, but not depression symptoms, increased dramatically during COVID-19 among people with a pre-existing medical condition.
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- 2020
15. What helps or hinders hearing aid wearers to change hearing aid programs?
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Welling, J, Krug, AE, Fischer, RL, Schinkel-Bielefeld, N, Welling, J, Krug, AE, Fischer, RL, and Schinkel-Bielefeld, N
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- 2020
16. A new comprehensive trait database of European and Maghreb butterflies, Papilionoidea
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Middleton-Welling, J., Dapporto, L., García-Barros, E., Wiemers, Martin, Nowicki, P., Plazio, E., Bonelli, S., Zaccagno, M., Šašić, M., Liparova, J., Schweiger, Oliver, Harpke, Alexander, Musche, Martin, Settele, Josef, Schmucki, R., Shreeve, T., Middleton-Welling, J., Dapporto, L., García-Barros, E., Wiemers, Martin, Nowicki, P., Plazio, E., Bonelli, S., Zaccagno, M., Šašić, M., Liparova, J., Schweiger, Oliver, Harpke, Alexander, Musche, Martin, Settele, Josef, Schmucki, R., and Shreeve, T.
- Abstract
Trait-based analyses explaining the different responses of species and communities to environmental changes are increasing in frequency. European butterflies are an indicator group that responds rapidly to environmental changes with extensive citizen science contributions to documenting changes of abundance and distribution. Species traits have been used to explain long- and short-term responses to climate, land-use and vegetation changes. Studies are often characterised by limited trait sets being used, with risks that the relative roles of different traits are not fully explored. Butterfly trait information is dispersed amongst various sources and descriptions sometimes differ between sources. We have therefore drawn together multiple information sets to provide a comprehensive trait database covering 542 taxa and 25 traits described by 217 variables and sub-states of the butterflies of Europe and Maghreb (northwest Africa) which should serve for improved trait-based ecological, conservation-related, phylogeographic and evolutionary studies of this group of insects. We provide this data in two forms; the basic data and as processed continuous and multinomial data, to enhance its potential usage.
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- 2020
17. PARE0009 COMMUNITY ADVISORY BOARD INPUT CAN MAKE LAY SUMMARIES OF CLINICAL TRIAL RESULTS MORE UNDERSTANDABLE
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Welling, J., primary, Roennow, A., additional, Sauvé, M., additional, Brown, E., additional, Galetti, I., additional, Gonzalez, A., additional, Portales Guiraud, A. P., additional, Kennedy, A., additional, Leite, C., additional, Riggs, R. J., additional, Zheng, A., additional, Perkovic Popovic, M., additional, Gilbert, A., additional, Moros, L., additional, Sroka-Saidi, K., additional, Schindler, T., additional, and Finnern, H., additional
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- 2020
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18. Suursienten sienimyrkyt ja niiden vaikutukset
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Welling, J. (Janne)
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Tiivistelmä. Sienilajeja tunnetaan maailmanlaajuisesti noin 100 000 lajia, joista noin 100 on ihmiselle myrkyllisiä. Sienten myrkyt voidaan jakaa karkeasti solumyrkkyihin, hermomyrkkyihin sekä muihin myrkkyihin. Tämä työ tarkastelee näiden erilaisten yhdisteiden vaikutuksia nisäkkäissä sekä niiden mahdollisia merkityksiä sienten kannalta.
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- 2019
19. Shortening patient-reported outcome measures through optimal test assembly: Application to the Social Appearance Anxiety Scale in the Scleroderma Patient-centered Intervention Network Cohort
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Harel, D., Mills, S.D., Kwakkenbos, L., Carrier, M.E., Nielsen, K., Portales, A., Bartlett, S.J., Malcarne, V.L., Thombs, B.D., Baron, M., Furst, D.E., Gottesman, K., Mayes, M.D., Mouthon, L., Nielson, W.R., Riggs, R., Sauve, M., Wigley, F., Assassi, S., Boutron, I., Maia, A.C., El-Baalbaki, G., Ells, C., Ende, C. van den, Fligelstone, K., Fortune, C., Frech, T., Godard, D., Hudson, M., Impens, A., Jang, Y., Johnson, S.R., Kennedy, A.T., Korner, A., Larche, M., Leite, C., Marra, C., Pope, J., Reyna, T.S.R., Schouffoer, A.A., Steele, R.J., Suarez-Almazor, M.E., Welling, J., Wong-Rieger, D., Agard, C., Albert, A., Andre, M., Arsenault, G., Benmostefa, N., Benzidia, I., Berthier, S., Bissonnette, L., Boire, G., Bruns, A., Carreira, P., Casadevall, M., Chaigne, B., Chung, L., Cohen, P., Dagenais, P., Denton, C., Domsic, R., Dubois, S., Dunne, J.V., Dunogue, B., Esquinca, A., Fare, R., Farge-Bancel, D., Fortin, P.R., Gill, A., Gordon, J., Granel-Rey, B., Grange, C., Gyger, G., Hachulla, E., Hatron, P.Y., Herrick, A.L., Hij, A., Hinchcliff, M., Ikic, A., Jones, N., Fernandes, A.J.D., Kafaja, S., Khalidi, N., Korman, B., Launay, D., Liang, P., London, J., Luna, D., Maillard, H., Manning, J., Martin, M., Martin, T., Masetto, A., Maurier, F., Mekinian, A., Melchor, S., Nikpour, M., Paule, R., Proudman, S., Regent, A., Riviere, S., Robinson, D., Rodriguez, E., Roux, S., Smets, P., Smith, D., Sobanski, V., Spiera, R., Steen, V., Stevens, W., Sutton, E., Terrier, B., Thorne, C., Varga, J., Wilcox, P., Wilson, M., Cumin, J., Fox, R.S., Gholizadeh, S., Jewett, L.R., Levis, B., Pepin, M.R., Turner, K.A., Lambert, M., and SPIN Investigators
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Adult ,Male ,medicine.medical_specialty ,systemic sclerosis ,Concurrent validity ,Anxiety ,Fear of negative evaluation ,Cohort Studies ,Experimental Psychopathology and Treatment ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Cronbach's alpha ,medicine ,Humans ,Patient Reported Outcome Measures ,optimal test assembly ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,Scleroderma, Systemic ,business.industry ,Research ,short form ,Social anxiety ,Reproducibility of Results ,generalized partial credit model ,General Medicine ,Middle Aged ,stomatognathic diseases ,Cross-Sectional Studies ,Convergent validity ,patient reported outcome measure ,Physical Appearance, Body ,Physical therapy ,Female ,Patient-reported outcome ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
ObjectivesThe Social Appearance Anxiety Scale (SAAS) is a 16-item measure that assesses social anxiety in situations where appearance is evaluated. The objective was to use optimal test assembly (OTA) methods to develop and validate a short-form SAAS based on objective and reproducible criteria.DesignThis study was a cross-sectional analysis of baseline data from adults enrolled in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort.SettingAdults in the SPIN Cohort in the present study were enrolled at 28 centres in Canada, the USA and the UK.ParticipantsThe SAAS was administered to 926 adults with scleroderma.Primary and secondary measuresThe SAAS, Brief Fear of Negative Evaluation II (BFNE II), Brief Satisfaction with Appearance Scale (Brief-SWAP), Patient Health Questionnaire-8 (PHQ8) and Social Interaction Anxiety Scale-6 (SIAS-6) were collected, as well as demographic characteristics.ResultsOTA methods identified a maximally informative shortened version for each possible form length between 1 and 15 items. The final shortened version was selected based on prespecified criteria for reliability, concurrent validity and statistically equivalent convergent validity with the BFNE II scale. A five-item short version was selected (SAAS-5). The SAAS-5 had a Cronbach’s α of 0.95 and had high concurrent validity with the full-length form (r=0.97). The correlation of the SAAS-5 with the BFNE II was 0.66, which was statistically equivalent to that of the full-length form. Furthermore, the correlation of the SAAS-5 with the two subscales of the Brief-SWAP, and the SIAS-6, were statistically equivalent to that of the full-length form.ConclusionsOTA was an efficient method for shortening the full-length SAAS to create the SAAS-5.
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- 2019
20. Zur Ermittlung der Trocknungsqualität von Schnittholz
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Welling, J.
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- 1996
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21. Plötzlicher Tod bei obstruktiver Schlafapnoe
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Welling, J.
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- 2005
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22. Update of EULAR recommendations for the treatment of systemic sclerosis
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Kowal-Bielecka O., Fransen J., Avouac J., Becker M., Kulak A., Allanore Y., Distler O., Clements P., Cutolo M., Czirjak L., Damjanov N., Del Galdo F., Denton C. P., Distler J. H. W., Foeldvari I., Figelstone K., Frerix M., Furst D. E., Guiducci S., Hunzelmann N., Khanna D., Matucci-Cerinic M., Herrick A. L., Van Den Hoogen F., Van Laar J. M., Riemekasten G., Silver R., Smith V., Sulli A., Tarner I., Tyndall A., Welling J., Wigley F., Valentini G., Walker U. A., Zulian F., Muller-Ladner U., Daikeler T., Lanciano E., Becvar R., Tomcik M., Gindzienska-Sieskiewicz E., Cuomo G., Iudici M., Rednic S., Vlachoyiannopoulos P. G., Caporali R., Carreira P. E., Novak S., Minier T., Kucharz E. J., Gabrielli A., Moroncini G., Airo' P., Hesselstrand R., Martinovic D., Radic M., Marasovic-Krstulovic D., Braun-Moscovici Y., Balbir-Gurman A., Lo Monaco A., Caramaschi P., Morovic-Vergles J., Henes J., Ortiz Santamaria V., Heitmann S., Krasowska D., Seidel M. F., Hasler P., Pereira Da Silva J. A., Salvador M. J., Stamenkovic B., Stankovic A., Tikly M., Ananieva L. P., Beretta L., Szucs G., Szamosi S., de la Puente Bujidos C., Midtvedt O., Hoffmann-Vold A. -M., Launay D., Hachulla E., Riccieri V., Ionescu R., Opris D., Mihai C., Herrgott I., Beyer C., Ingegnoli F., von Muhlen C. A., Alegre-Sancho J. J., Beltran-Catalan E., Aringer M., Fantana J., Leuchten N., Tausche A. -K., De Langhe E., Vanthuyne M., Anic B., Baresic M., Mayer M., Uprus M., Otsa K., Yavuz S., Granel B., Azevedo V. F., Muller C., Jimenez S. A., Popa S., Agachi S., Zenone T., Stebbings S., Dockerty J., Vacca A., Schollum J., Veale D. J., Toloza S., Xu D., Olas J., Rosato E., Foti R., Adler S., Dan D., Wiesik-Szewczyk E., Olesinska M., Kayser C., Fathi N., de la Pena Lefebvre P. G., Imbert B., Kowal-Bielecka, O., Fransen, J., Avouac, J., Becker, M., Kulak, A., Allanore, Y., Distler, O., Clements, P., Cutolo, M., Czirjak, L., Damjanov, N., Del Galdo, F., Denton, C. P., Distler, J. H. W., Foeldvari, I., Figelstone, K., Frerix, M., Furst, D. E., Guiducci, S., Hunzelmann, N., Khanna, D., Matucci-Cerinic, M., Herrick, A. L., Van Den Hoogen, F., Van Laar, J. M., Riemekasten, G., Silver, R., Smith, V., Sulli, A., Tarner, I., Tyndall, A., Welling, J., Wigley, F., Valentini, G., Walker, U. A., Zulian, F., Muller-Ladner, U., Daikeler, T., Lanciano, E., Becvar, R., Tomcik, M., Gindzienska-Sieskiewicz, E., Cuomo, G., Iudici, M., Rednic, S., Vlachoyiannopoulos, P. G., Caporali, R., Carreira, P. E., Novak, S., Minier, T., Kucharz, E. J., Gabrielli, A., Moroncini, G., Airo', P., Hesselstrand, R., Martinovic, D., Radic, M., Marasovic-Krstulovic, D., Braun-Moscovici, Y., Balbir-Gurman, A., Lo Monaco, A., Caramaschi, P., Morovic-Vergles, J., Henes, J., Ortiz Santamaria, V., Heitmann, S., Krasowska, D., Seidel, M. F., Hasler, P., Pereira Da Silva, J. A., Salvador, M. J., Stamenkovic, B., Stankovic, A., Tikly, M., Ananieva, L. P., Beretta, L., Szucs, G., Szamosi, S., de la Puente Bujidos, C., Midtvedt, O., Hoffmann-Vold, A. -M., Launay, D., Hachulla, E., Riccieri, V., Ionescu, R., Opris, D., Mihai, C., Herrgott, I., Beyer, C., Ingegnoli, F., von Muhlen, C. A., Alegre-Sancho, J. J., Beltran-Catalan, E., Aringer, M., Fantana, J., Leuchten, N., Tausche, A. -K., De Langhe, E., Vanthuyne, M., Anic, B., Baresic, M., Mayer, M., Uprus, M., Otsa, K., Yavuz, S., Granel, B., Azevedo, V. F., Muller, C., Jimenez, S. A., Popa, S., Agachi, S., Zenone, T., Stebbings, S., Dockerty, J., Vacca, A., Schollum, J., Veale, D. J., Toloza, S., Xu, D., Olas, J., Rosato, E., Foti, R., Adler, S., Dan, D., Wiesik-Szewczyk, E., Olesinska, M., Kayser, C., Fathi, N., de la Pena Lefebvre, P. G., Imbert, B., UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (MGD) Service de rhumatologie, Kowal Bielecka, Otylia, Fransen, Jaap, Avouac, Jerome, Becker, Mike, Kulak, Agnieszka, Allanore, Yannick, Distler, Oliver, Clements, Philip, Cutolo, Maurizio, Czirjak, Laszlo, Damjanov, Nemanja, del Galdo, Francesco, Denton, Christopher P., Distler, Jörg H. W., Foeldvari, Ivan, Figelstone, Kim, Frerix, Marc, Furst, Daniel E., Guiducci, Serena, Hunzelmann, Nicola, Khanna, Dinesh, Matucci Cerinic, Marco, Herrick, Ariane L., van den Hoogen, Frank, van Laar, Jacob M., Riemekasten, Gabriela, Silver, Richard, Smith, Vanessa, Sulli, Alberto, Tarner, Ingo, Tyndall, Alan, Welling, Joep, Wigley, Frederic, Valentini, Gabriele, Walker, Ulrich A., Zulian, Francesco, Müller Ladner, Ulf, Daikeler, Thoma, Lanciano, Elisabetta, Becvã¡r, Radim, Tomcik, Michal, Gindzienska Sieskiewicz, Ewa, Iudici, Michele, Rednic, Simona, Vlachoyiannopoulos, Panayiotis G., Caporali, Roberto, Carreira, Patricia E., Novak, Srdan, Minier, Tã¼nde, Kucharz, Eugene J., Gabrielli, Armando, Moroncini, Gianluca, Airo, Paolo, Hesselstrand, Roger, Martinovic, Duska, Radic, Mislav, Marasovic Krstulovic, Daniela, Braun Moscovici, Yolanda, Monaco, Andrea Lo, Morovic Vergles, Jadranka, Culo, Melanie I., Henes, Jã¶rg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Michalska Jakubus, Malgorzata, Seidel, Matthias F., Klinik III, Medizinische, Hasler, Paul, Da Silva, José A. Pereira, Salvador, Maria J., Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Ananieva, Lidia P., Beretta, Lorenzo, Szucs, Gabriella, Szamosi, Szilvia, de la Puente Bujidos, Carlo, Midtvedt, Øyvind, Hoffmann Vold, Anna Maria, Launay, David, Hachulla, Eric, Riccieri, Valeria, Ionescu, Ruxandra, Opris, Daniela, Mihai, Carina, Herrgott, Ilka, Beyer, Christian, Ingegnoli, Francesca, von Mühlen, Carlos Alberto, Alegre Sancho, Juan José, Beltran Catalan, Emma, Aringer, Martin, Fantana, Julia, Leuchten, Nicolai, Tausche, Anne Kathrin, Langhe, Ellen De, Vanthuyne, Marie, Anic, Branimir, Bareå¡ic, Marko, Mayer, Miroslav, Ãœprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Jimenez, Sergio A., Popa, Serghei, Agachi, Svetlana, Zenone, Thierry, Stebbings, Simon, Dockerty, Joanne, Vacca, Alessandra, Schollum, Joanna, Veale, Douglas J., Toloza, Sergio, Xu, Dong, Olas, Jacek, Rosato, Edoardo, Foti, Rosario, Adler, Sabine, Dan, Diana, Wiesik Szewczyk, Ewa, Olesinska, Marzena, Kayser, Cristiane, Fathi, Nihal, de la Peña Lefebvre, Paloma GarcÃa, Imbert, Bernard, and Cuomo, Giovanna
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Endothelin Receptor Antagonists ,Lung Diseases ,Kidney Disease ,Delphi Technique ,Gastrointestinal Diseases ,systemic sclerosis ,Scleroderma Renal Crisis ,Placebo-controlled study ,Angiotensin-Converting Enzyme Inhibitors ,Lung Disease ,Scleroderma ,0302 clinical medicine ,Glucocorticoid ,Phosphodiesterase 5 Inhibitor ,Immunology and Allergy ,skin and connective tissue diseases ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina ,integumentary system ,treatment ,genetics and molecular biology (all) ,Hematopoietic Stem Cell Transplantation ,cyclophosphamide ,methotrexate ,Pulmonary ,Orvostudományok ,Serotonin Uptake Inhibitor ,3. Good health ,Europe ,Systematic review ,Hypertension ,Serotonin Uptake Inhibitors ,Cyclophosphamide ,Methotrexate ,Systemic Sclerosis ,Treatment ,Fingers ,Fluoxetine ,Glucocorticoids ,Humans ,Hypertension, Pulmonary ,Kidney Diseases ,Phosphodiesterase 5 Inhibitors ,Prostaglandins I ,Pyrazoles ,Pyrimidines ,Raynaud Disease ,Rheumatology ,Scleroderma, Systemic ,Ulcer ,Immunology ,Biochemistry, Genetics and Molecular Biology (all) ,030211 gastroenterology & hepatology ,Endothelin Receptor Antagonist ,Selective Serotonin Reuptake Inhibitors ,medicine.drug ,Human ,medicine.medical_specialty ,Gastrointestinal Disease ,Klinikai orvostudományok ,Riociguat ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,medicine ,Finger ,biochemistry ,Intensive care medicine ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine ,Systemic Sclerosi ,030203 arthritis & rheumatology ,business.industry ,Systemic ,Angiotensin-Converting Enzyme Inhibitor ,medicine.disease ,Transplantation ,Clinical research ,Pyrimidine ,immunology and allergy ,rheumatology ,immunology ,Pyrazole ,Physical therapy ,business ,Rheumatism - Abstract
The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the previous treatment recommendations was performed according to EULAR standard operating procedures. The task force consisted of 32 SSc clinical experts from Europe and the USA, 2 patients nominated by the pan-European patient association for SSc (Federation of European Scleroderma Associations (FESCA)), a clinical epidemiologist and 2 research fellows. All centres from the EULAR Scleroderma Trials and Research group were invited to submit and select clinical questions concerning SSc treatment using a Delphi approach. Accordingly, 46 clinical questions addressing 26 different interventions were selected for systematic literature review. The new recommendations were based on the available evidence and developed in a consensus meeting with clinical experts and patients. The procedure resulted in 16 recommendations being developed (instead of 14 in 2009) that address treatment of several SSc-related organ complications: Raynaud's phenomenon (RP), digital ulcers (DUs), pulmonary arterial hypertension (PAH), skin and lung disease, scleroderma renal crisis and gastrointestinal involvement. Compared with the 2009 recommendations, the 2016 recommendations include phosphodiesterase type 5 (PDE-5) inhibitors for the treatment of SSc-related RP and DUs, riociguat, new aspects for endothelin receptor antagonists, prostacyclin analogues and PDE-5 inhibitors for SSc-related PAH. New recommendations regarding the use of fluoxetine for SSc-related RP and haematopoietic stem cell transplantation for selected patients with rapidly progressive SSc were also added. In addition, several comments regarding other treatments addressed in clinical questions and suggestions for the SSc research agenda were formulated. These updated data-derived and consensus-derived recommendations will help rheumatologists to manage patients with SSc in an evidence-based way. These recommendations also give directions for future clinical research in SSc.
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- 2017
23. Chartis Measurement of Collateral Ventilation: Conscious Sedation Versus General Anesthesia
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Welling, J., Hartman, J. E., Ten Hacken, N. H. T., Kerstjens, H. A. M., Klooster, K., Slebos, D., Lifestyle Medicine (LM), and Groningen Research Institute for Asthma and COPD (GRIAC)
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- 2018
24. Update of EULAR recommendations for the treatment of systemic sclerosis
- Author
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Kowal-Bielecka, O. Fransen, J. Avouac, J. Becker, M. Kulak, A. Allanore, Y. Distler, O. Clements, P. Cutolo, M. Czirjak, L. Damjanov, N. Del Galdo, F. Denton, C.P. Distler, J.H.W. Foeldvari, I. Figelstone, K. Frerix, M. Furst, D.E. Guiducci, S. Hunzelmann, N. Khanna, D. Matucci-Cerinic, M. Herrick, A.L. Van Den Hoogen, F. Van Laar, J.M. Riemekasten, G. Silver, R. Smith, V. Sulli, A. Tarner, I. Tyndall, A. Welling, J. Wigley, F. Valentini, G. Walker, U.A. Zulian, F. Müller-Ladner, U. EUSTAR Coauthors Daikeler, T. Lanciano, E. Becvár, R. Tomcik, M. Gińdzieńska-Sieskiewicz, E. Cuomo, G. Iudici, M. Rednic, S. Vlachoyiannopoulos, P.G. Caporali, R. Carreira, P.E. Novak, S. Minier, T. Kucharz, E.J. Gabrielli, A. Moroncini, G. Airo', P. Hesselstrand, R. Martinovic, D. Radic, M. Marasovic-Krstulovic, D. Braun-Moscovici, Y. Balbir-Gurman, A. Lo Monaco, A. Caramaschi, P. Morovic-Vergles, J. Henes, J. Ortiz Santamaria, V. Heitmann, S. Krasowska, D. Seidel, M.F. Hasler, P. Pereira Da Silva, J.A. Salvador, M.J. Stamenkovic, B. Stankovic, A. Tikly, M. Ananieva, L.P. Beretta, L. Szucs, G. Szamosi, S. de la Puente Bujidos, C. Midtvedt, Ø. Hoffmann-Vold, A.-M. Launay, D. Hachulla, E. Riccieri, V. Ionescu, R. Opris, D. Mihai, C. Herrgott, I. Beyer, C. Ingegnoli, F. von Mühlen, C.A. Alegre-Sancho, J.J. Beltrán-Catalán, E. Aringer, M. Fantana, J. Leuchten, N. Tausche, A.-K. De Langhe, E. Vanthuyne, M. Anic, B. Barešic, M. Mayer, M. Üprus, M. Otsa, K. Yavuz, S. Granel, B. Azevedo, V.F. Muller, C. Jimenez, S.A. Popa, S. Agachi, S. Zenone, T. Stebbings, S. Dockerty, J. Vacca, A. Schollum, J. Veale, D.J. Toloza, S. Xu, D. Olas, J. Rosato, E. Foti, R. Adler, S. Dan, D. Wiesik-Szewczyk, E. Olesińska, M. Kayser, C. Fathi, N. de la Peña Lefebvre, P.G. Imbert, B.
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integumentary system ,skin and connective tissue diseases - Abstract
The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the previous treatment recommendations was performed according to EULAR standard operating procedures. The task force consisted of 32 SSc clinical experts from Europe and the USA, 2 patients nominated by the pan-European patient association for SSc (Federation of European Scleroderma Associations (FESCA)), a clinical epidemiologist and 2 research fellows. All centres from the EULAR Scleroderma Trials and Research group were invited to submit and select clinical questions concerning SSc treatment using a Delphi approach. Accordingly, 46 clinical questions addressing 26 different interventions were selected for systematic literature review. The new recommendations were based on the available evidence and developed in a consensus meeting with clinical experts and patients. The procedure resulted in 16 recommendations being developed (instead of 14 in 2009) that address treatment of several SSc-related organ complications: Raynaud's phenomenon (RP), digital ulcers (DUs), pulmonary arterial hypertension (PAH), skin and lung disease, scleroderma renal crisis and gastrointestinal involvement. Compared with the 2009 recommendations, the 2016 recommendations include phosphodiesterase type 5 (PDE-5) inhibitors for the treatment of SSc-related RP and DUs, riociguat, new aspects for endothelin receptor antagonists, prostacyclin analogues and PDE-5 inhibitors for SSc-related PAH. New recommendations regarding the use of fluoxetine for SSc-related RP and haematopoietic stem cell transplantation for selected patients with rapidly progressive SSc were also added. In addition, several comments regarding other treatments addressed in clinical questions and suggestions for the SSc research agenda were formulated. These updated data-derived and consensus-derived recommendations will help rheumatologists to manage patients with SSc in an evidence-based way. These recommendations also give directions for future clinical research in SSc. © Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
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- 2017
25. Factors associated with patient-reported likelihood of using online self-care interventions: a Scleroderma Patient-centered Intervention Network (SPIN) cohort study
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Kwakkenbos, L. (Linda), Cumin, J. (Julie), Carrier, M. (Marie-Eve), Bartlett, S. (Susan J), Malcarne, V. (Vanessa L), Mouthon, L. (Luc), Nielson, W. (Warren R), Rannou, F. (François), Welling, J. (Joep), Thombs, B. (Brett D), Martin, T. (Thierry), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
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Male ,Internationality ,systemic sclerosis ,Aucun ,Psychological intervention ,law.invention ,Cohort Studies ,Experimental Psychopathology and Treatment ,0302 clinical medicine ,Randomized controlled trial ,law ,Patient-Centered Care ,scleroderma ,030212 general & internal medicine ,ComputingMilieux_MISCELLANEOUS ,Original Research ,cmRCT ,General Medicine ,3. Good health ,Cohort ,Female ,France ,Cohort study ,Canada ,medicine.medical_specialty ,Multiple Sclerosis ,Patient-Centred Medicine ,03 medical and health sciences ,Intervention (counseling) ,cohort multiple RCT ,medicine ,Humans ,Patient Reported Outcome Measures ,Mexico ,030203 arthritis & rheumatology ,clinical trials ,Internet ,business.industry ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Self-care interventions ,Self Care ,Clinical trial ,Cross-Sectional Studies ,Spain ,Family medicine ,Multivariate Analysis ,Linear Models ,business ,Patient centered - Abstract
ObjectivesThe Scleroderma Patient-centered Intervention Network (SPIN) Cohort uses the cohort multiple randomised controlled trial design to embed trials of online self-care interventions for people living with systemic sclerosis (SSc; scleroderma). To offer interventions to patients interested in using them, participants complete signalling items that query about the likelihood that patients would agree to participate in nine different hypothetical online programmes addressing common SSc-related problems. It is not known what factors influence patient-reported interest in participating in a particular online intervention and if intervention-specific signalling questions provide unique information or replicate broader characteristics, such as overall willingness to participate or self-efficacy. This study assessed factors that explain responses to intervention-specific signalling items.DesignCross-sectional survey.SettingSPIN Cohort participants enrolled at 42 centres from Canada, the USA, the UK, France, Spain and Mexico who completed study questionnaires from March 2014 to January 2018 were included.MeasuresDemographic and disease characteristics, self-efficacy and symptoms related to each specific intervention were completed in addition to signalling items. General likelihood of using interventions was calculating by taking the mean score of the remaining signalling questions.Participants1060 participants with complete baseline data were included in the analyses.ResultsFor all individual signalling questions, controlling for other variables, the mean of the remaining signalling questions was the strongest predictor (standardised regression coefficient β from 0.61 (sleep) to 0.80 (self-management)). Smaller, but statistically significant, associations were found with the symptom associated with the respective signalling question and with general self-efficacy for 7 of 9 signalling questions.ConclusionsThe main factor associated with patients’ interest in participating in a disease-specific online self-care intervention is their general interest in participating in online interventions. Factors that may influence this general interest should be explored and taken into consideration when inviting patients to try online interventions.
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- 2019
26. Never-ending learning
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Mitchell, T., primary, Cohen, W., additional, Hruschka, E., additional, Talukdar, P., additional, Yang, B., additional, Betteridge, J., additional, Carlson, A., additional, Dalvi, B., additional, Gardner, M., additional, Kisiel, B., additional, Krishnamurthy, J., additional, Lao, N., additional, Mazaitis, K., additional, Mohamed, T., additional, Nakashole, N., additional, Platanios, E., additional, Ritter, A., additional, Samadi, M., additional, Settles, B., additional, Wang, R., additional, Wijaya, D., additional, Gupta, A., additional, Chen, X., additional, Saparov, A., additional, Greaves, M., additional, and Welling, J., additional
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- 2018
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27. J. Harry Welling, letter, 1917-03-10, to Hamlin Garland
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Garland, Hamlin, 1860-1940, recipient, Welling, J. Harry; Vigilantes, Garland, Hamlin, 1860-1940, recipient, and Welling, J. Harry; Vigilantes
- Abstract
J. Harry Welling (The Vigilantes), 110 West 34th Street, New York, New York, USA, letter, 1917 March 10, to Hamlin Garland, 71 East 92nd Street, New York, New York, USA. "There is to be a meeting of the Executive Committee Monday March 12th, at 5:15 P.M., and if possible for you to do so, would like to have you attend." -- first line.
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- 2017
28. SågELS-handboken
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Lycken, Anders, Nilsson, Daniel, Olsson, Marcus, Diederichs, Stefan, Welling, J, and Guennec, Tifenn
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Naturvetenskap ,Natural Sciences - Abstract
Translated by Anders Lycken, Daniel Nilsson, Oskar Räftegård och Marcus Olsson
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- 2015
29. Zeitschriftenreferate
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Welling, J., Stoll, M., Schwab, E., Fortuin, G., Rügge, K., and DGfG/EGH
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- 1990
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30. Buchbesprechungen
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Stoll, M. and Welling, J.
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- 1996
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31. Buchbesprechungen
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Welling, J.
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- 1994
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32. Drying of polymeric and solid materials. Modelling and industrial applications: Vergnaud, J.-M.: XX/336 S.; 216 Abb. Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong 1992: Springer-Verlarg, ISBN 3-540-19738-9. Geb. DM 285
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Welling, J.
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- 1993
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33. Development of EULAR recommendations for the reporting of clinical trial extension studies in rheumatology
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Buch, Mh, Silva Fernandez, L, Carmona, L, Aletaha, D, Christensen, R, Combe, B, Emery, P, Ferraccioli, Gianfranco, Guillemin, F, Kvien, Tk, Landewe, R, Pavelka, K, Saag, K, Smolen, J, Symmons, D, Van Der Heijde, D, Welling, J, Wells, G, Westhovens, R, Zink, A, Boers, M., Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428), Buch, Mh, Silva Fernandez, L, Carmona, L, Aletaha, D, Christensen, R, Combe, B, Emery, P, Ferraccioli, Gianfranco, Guillemin, F, Kvien, Tk, Landewe, R, Pavelka, K, Saag, K, Smolen, J, Symmons, D, Van Der Heijde, D, Welling, J, Wells, G, Westhovens, R, Zink, A, Boers, M., and Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428)
- Abstract
Our initiative aimed to produce recommendations on post-randomised controlled trial (RCT) trial extension studies (TES) reporting using European League Against Rheumatism (EULAR) standard operating procedures in order to achieve more meaningful output and standardisation of reports.
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- 2015
34. Die modellmäßige Erfassung von Trocknungsspannungen während der Kammertrocknung von Schnittholz
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Welling, J.
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- 1988
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35. Computergesteuertes Datenerfassungssystem für die Schnittholztrocknung
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Welling, J. and Ressel, J.
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- 1985
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36. Überprüfung berechneter Trocknungsspannungs-Verteilungen durch einen experimentellen quantitativen Spannungsnachweis
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Welling, J. and Fortuin, G.
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- 1989
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37. OP0061 Update of Eular Recommendations for the Treatment of Systemic Sclerosis
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Kowal-Bielecka, O., primary, Fransen, J., additional, Avouac, J., additional, Becker, M., additional, Kulak, A., additional, Allanore, Y., additional, Distler, O., additional, Czirjak, L., additional, Denton, C.P., additional, Fligelstone, K., additional, Welling, J., additional, and Mueller-Ladner, U., additional
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- 2015
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38. AB0711 Optimizing Scleroderma Centers of Excellence: Perspectives From Patients and Systemic Sclerosis (SSC) Experts
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Jaeger, V., primary, Aubin, A., additional, Baldwin, N., additional, Fligelstone, K., additional, Sims, R., additional, Welling, J., additional, Burrill, R., additional, Connolly, K., additional, Gordon, J.K., additional, Frech, T., additional, Ngcozana, T., additional, Kowalczyk, M., additional, Lammi, M.R., additional, Lasky, J.A., additional, Walker, U.A., additional, and Saketkoo, L.A., additional
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- 2015
- Full Text
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39. Development of EULAR recommendations for the reporting of clinical trial extension studies in rheumatology
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Buch, Mh, Silva Fernandez, L, Carmona, L, Aletaha, D, Christensen, R, Combe, B, Emery, P, Ferraccioli, Gianfranco, Guillemin, F, Kvien, Tk, Landewe, R, Pavelka, K, Saag, K, Smolen, J, Symmons, D, Van Der Heijde, D, Welling, J, Wells, G, Westhovens, R, Zink, A, Boers, M., Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428), Buch, Mh, Silva Fernandez, L, Carmona, L, Aletaha, D, Christensen, R, Combe, B, Emery, P, Ferraccioli, Gianfranco, Guillemin, F, Kvien, Tk, Landewe, R, Pavelka, K, Saag, K, Smolen, J, Symmons, D, Van Der Heijde, D, Welling, J, Wells, G, Westhovens, R, Zink, A, Boers, M., and Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428)
- Abstract
Our initiative aimed to produce recommendations on post-randomised controlled trial (RCT) trial extension studies (TES) reporting using European League Against Rheumatism (EULAR) standard operating procedures in order to achieve more meaningful output and standardisation of reports.
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- 2014
40. Zeitschriftenreferate
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Burmester, A., Welling, J., Rügge, K., Peek, R. -D., Schwab, E., Seehann, G., Plath, L., Rügge, K., Albin, R., Bröker, F. -W., and Huy, V. -R.
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- 1982
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41. Zeitschriftenreferate
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Seehann, G., Schmitt, U., Dujesielken, D., Bues, C. T., Willeitner, H., Schmidt, O., Richter, H. G., Bröker, F. -W., Schwab, E., and Welling, J.
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- 1988
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42. Zeitschriftenreferate
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Schwab, E., Bröker, F. -W., v. Roth, W., Weißmann, G., Graves, K., Roffael, E., Welling, J., and Rügge, K.
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- 1989
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43. Zeitschriftenreferate
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Schmidt, O., Dujesiefken, D., Seehann, G., Schab, E., Welling, J., and v. Roth, W.
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- 1989
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44. Zeitschriftenreferate
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Schwab, E., Roffael, E., Puls, J., Weißmann, G., Boehme, C., Boehme, Bröker, F. -W., Welling, J., and Seehann, G.
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- 1988
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45. Suppressorzellen myeloischen Ursprungs (Myeloid-derived suppressor cells) im Blut von Krebspatienten enthalten unreife neutrophile Granulozyten mit eingeschränkten Migrationseigenschaften
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Trellakis, S, Lang, S, Elian, M, Bruderek, K, Schmaltz, D, Suttmann, H, Schenck, M, Welling, J, Zabel, P, Brandau, S, Trellakis, S, Lang, S, Elian, M, Bruderek, K, Schmaltz, D, Suttmann, H, Schenck, M, Welling, J, Zabel, P, and Brandau, S
- Published
- 2011
46. Maintaining vaccine delivery following the introduction of the rotavirus and pneumococcal vaccines in Thailand
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Lee, BY, Assi, TM, Rookkapan, K, Wateska, AR, Rajgopal, J, Sornsrivichai, V, Chen, SI, Brown, ST, Welling, J, Norman, BA, Connor, DL, Bailey, RR, Jana, A, van Panhuis, WG, Burke, DS, Lee, BY, Assi, TM, Rookkapan, K, Wateska, AR, Rajgopal, J, Sornsrivichai, V, Chen, SI, Brown, ST, Welling, J, Norman, BA, Connor, DL, Bailey, RR, Jana, A, van Panhuis, WG, and Burke, DS
- Abstract
Although the substantial burdens of rotavirus and pneumococcal disease have motivated many countries to consider introducing the rotavirus vaccine (RV) and heptavalent pneumococcal conjugate vaccine (PCV-7) to their National Immunization Programs (EPIs), these new vaccines could affect the countries' vaccine supply chains (i.e., the series of steps required to get a vaccine from their manufacturers to patients). We developed detailed computational models of the Trang Province, Thailand, vaccine supply chain to simulate introducing various RV and PCV-7 vaccine presentations and their combinations. Our results showed that the volumes of these new vaccines in addition to current routine vaccines could meet and even exceed (1) the refrigerator space at the provincial district and sub-district levels and (2) the transport cold space at district and sub-district levels preventing other vaccines from being available to patients who arrive to be immunized. Besides the smallest RV presentation (17.1 cm 3/dose), all other vaccine introduction scenarios required added storage capacity at the provincial level (range: 20 L-1151 L per month) for the three largest formulations, and district level (range: 1 L-124 L per month) across all introduction scenarios. Similarly, with the exception of the two smallest RV presentation (17.1 cm 3/dose), added transport capacity was required at both district and sub-district levels. Added transport capacity required across introduction scenarios from the provincial to district levels ranged from 1 L-187 L, and district to sub-district levels ranged from 1 L-13 L per shipment. Finally, only the smallest RV vaccine presentation (17.1 cm 3/dose) had no appreciable effect on vaccine availability at sub-districts. All other RV and PCV-7 vaccines were too large for the current supply chain to handle without modifications such as increasing storage or transport capacity. Introducing these new vaccines to Thailand could have dynamic effects on the ava
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- 2011
47. Idiopathische lymphozytäre interstitielle Pneumonie mit sequentiell auftretendem pulmonalem Non-Hodgkin-Lymphom
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Hörster, R, primary, Marxsen, J, additional, Eberhardt, F, additional, Welling, J, additional, Dalhoff, K, additional, and Drömann, D, additional
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- 2012
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48. Product emissions of volatile organic compounds from convection dried Norway spruce (Picea abies(L.) H. Karst.) timber
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Steckel, V, primary, Welling, J, additional, and Ohlmeyer, M, additional
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- 2011
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49. Comparison of foam core materials in innovative lightweight wood-based panels
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Shalbafan, A., primary, Luedtke, J., additional, Welling, J., additional, and Thoemen, H., additional
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- 2011
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50. Correspondence.
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Welling, James C., Summers, Geo W., and Welling, J. C.
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LETTERS to the editor ,POLITICAL parties ,ASSOCIATIONS, institutions, etc. ,EDUCATION ,LEGISLATIVE amendments ,CONFERENCES & conventions ,MEETINGS - Abstract
Presents letters to the editor related to articles previously published. Views on Democratic Party; Duty of Government regarding education of people; Amendments proposed by the "Peace Conference" with some verbal modifications to remove cavil.
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- 1879
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