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1,358 results on '"Wells, Karen"'

7. Generation and gender: theorising social reproduction in rural West Africa.

Author

Wells, Karen

Subjects
*QUESTION & answer websites, *SOCIAL reproduction, *AGE groups, *CHILD development, *UNPAID labor
Abstract

This paper argues for generation to be incorporated into the analysis of social reproduction to open new ways of thinking about the significance of children's unpaid work in and for their families. This paper situates its argument in relation to social reproduction theory and the conceptualization of generation in childhood studies and development studies. It draws on a longitudinal study of girls growing up in contemporary Benin and Togo conducted by Plan Benin and Plan Togo. This paper shows how the work of social reproduction is distributed across the household with children, especially girls, playing a large part in these activities. Trading and farming are the main economic activities of women, and girls gradually extend their knowledge of how to farm and trade as they get older. This paper concludes that placing generation into the centre of social reproduction theory will not only make visible the work that children do in subsistence economies but is also important for answering the perennial question of social reproduction theory in capitalist economies: who pays for that 'strange commodity', 'living labour' to be reproduced. [ABSTRACT FROM AUTHOR]

Published
2024
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8. How Substance Users With ADHD Perceive the Relationship Between Substance Use and Emotional Functioning.

Author

Mitchell, John T, Weisner, Thomas S, Jensen, Peter S, Murray, Desiree W, Molina, Brooke SG, Arnold, L Eugene, Hechtman, Lily, Swanson, James M, Hinshaw, Stephen P, Victor, Elizabeth C, Kollins, Scott H, Wells, Karen C, Belendiuk, Katherine A, Blonde, Andrew, Nguyen, Celeste, Ambriz, Lizeth, and Nguyen, Jenny L

Subjects
Humans, Substance-Related Disorders, Combined Modality Therapy, Emotions, Attention Deficit Disorder with Hyperactivity, Qualitative Research, Adult, Child, Female, Male, Interviews as Topic, Young Adult, ADHD, MTA study, qualitative research, substance use, Mental Health, Drug Abuse (NIDA only), Basic Behavioral and Social Science, Clinical Research, Substance Misuse, Attention Deficit Hyperactivity Disorder (ADHD), Pediatric, Behavioral and Social Science, Mental health, Good Health and Well Being, Psychology, Developmental & Child Psychology
Abstract

ObjectiveAlthough substance use (SU) is elevated in ADHD and both are associated with disrupted emotional functioning, little is known about how emotions and SU interact in ADHD. We used a mixed qualitative-quantitative approach to explore this relationship.MethodNarrative comments were coded for 67 persistent (50 ADHD, 17 local normative comparison group [LNCG]) and 25 desistent (20 ADHD, 5 LNCG) substance users from the Multimodal Treatment Study of Children with ADHD (MTA) adult follow-up (21.7-26.7 years-old).ResultsSU persisters perceived SU positively affects emotional states and positive emotional effects outweigh negative effects. No ADHD group effects emerged. Qualitative analysis identified perceptions that cannabis enhanced positive mood for ADHD and LNCG SU persisters, and improved negative mood and ADHD for ADHD SU persisters.ConclusionPerceptions about SU broadly and mood do not differentiate ADHD and non-ADHD SU persisters. However, perceptions that cannabis is therapeutic may inform ADHD-related risk for cannabis use.

Published
2018

9. Follow-Up of Young Adults With ADHD in the MTA: Design and Methods for Qualitative Interviews.

Author

Weisner, Thomas S, Murray, Desiree W, Jensen, Peter S, Mitchell, John T, Swanson, James M, Hinshaw, Stephen P, Wells, Karen, Hechtman, Lily, Molina, Brooke SG, Arnold, L Eugene, Sorensen, Page, and Stehli, Annamarie

Subjects
Humans, Substance-Related Disorders, Central Nervous System Stimulants, Treatment Outcome, Combined Modality Therapy, Narration, Follow-Up Studies, Attention Deficit Disorder with Hyperactivity, Psychiatric Status Rating Scales, Qualitative Research, Adolescent, Child, Female, Male, Interviews as Topic, Young Adult, ADHD, MTA study, mixed methods, qualitative research, substance use, Pediatric, Attention Deficit Hyperactivity Disorder (ADHD), Mental Health, Clinical Research, Good Health and Well Being, Psychology, Developmental & Child Psychology
Abstract

ObjectiveQualitative interviews with 183 young adults (YA) in the follow-up of the Multimodal Treatment Study of Children With and Without ADHD (MTA) provide rich information on beliefs and expectations regarding ADHD, life's turning points, medication use, and substance use (SU).MethodParticipants from four MTA sites were sampled to include those with persistent and atypically high SU, and a local normative comparison group (LNCG). Respondents were encouraged to "tell their story" about their lives, using a semistructured conversational interview format.ResultsInterviews were reliably coded for interview topics. ADHD youth more often desisted from SU because of seeing others going down wrong paths due to SU. Narratives revealed very diverse accounts and explanations for SU-ADHD influences.ConclusionQualitative methods captured the perspectives of YAs regarding using substances. This information is essential for improving resilience models in drug prevention and treatment programs and for treatment development for this at-risk population.

Published
2018

10. Turning Points in the Lives of Youth of With/Without ADHD: Are They Linked to Changes in Substance Use?

Author

Jensen, Peter S, Yuki, Kumi, Murray, Desiree, Mitchell, John T, Weisner, Thomas, Hinshaw, Steven, Molina, Brooke, Swanson, James, Arnold, L Eugene, Hechtman, Lily, and Wells, Karen

Subjects
Humans, Substance-Related Disorders, Self Efficacy, Decision Making, Attention Deficit Disorder with Hyperactivity, Social Support, Adolescent, Adult, Female, Male, ADHD, decision-making, mixed methods, self-efficacy, stages of change, substance use, theory of reasoned action, turning points, unified theory of behavior, Drug Abuse (NIDA only), Mental Health, Basic Behavioral and Social Science, Clinical Research, Attention Deficit Hyperactivity Disorder (ADHD), Substance Misuse, Behavioral and Social Science, Good Health and Well Being, Psychology, Developmental & Child Psychology
Abstract

ObjectiveThis study examines the behavior beliefs, social supports, and turning points in individuals with/without ADHD related to their substance use/abuse (SU/A) decisions.MethodThe coded interviews from 60 participants with/without ADHD were compared for their SU/A decisions and precipitants with these decisions among abstainers, persisters, and desisters.ResultsADHD participants reported fewer social advantages to avoid SU/A than non-ADHD participants. Desisters and persisters reported more social advantages of using drugs than abstainers. Persisters reported both more negative and positive psychological/physiological effects of SU/A. ADHD participants reported fewer positive role models in their lives. Non-ADHD patients reported more positive turning points than ADHD participants, regardless of SU/A status.ConclusionADHD individuals face challenges in making healthy decisions about SU/A due to lack of positive role models. Reinforcing accurate behavioral beliefs may be important to change behaviors in individuals with SU/A or to prevent SU/A initiation in ADHD individuals.

Published
2018

13. Childhood Predictors of Adult Functional Outcomes in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (MTA)

Author

Roy, Arunima, Hechtman, Lily, Arnold, L Eugene, Swanson, James M, Molina, Brooke SG, Sibley, Margaret H, Howard, Andrea L, Group, MTA Cooperative, Vitiello, Benedetto, Severe, Joanne B, Jensen, Peter S, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P, Elliott, Glen R, Wells, Karen C, Epstein, Jeffery N, Murray, Desiree W, Conners, C Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P, Abikoff, Howard B, Greenhill, Laurence L, Newcorn, Jeffrey H, Molina, Brooke, Hoza, Betsy, Pelham, William E, Gibbons, Robert D, Marcus, Sue, Hur, Kwan, Kraemer, Helena C, Hanley, Thomas, and Stern, Karen

Subjects
Clinical and Health Psychology, Psychology, Prevention, Brain Disorders, Pediatric, Behavioral and Social Science, Pediatric Research Initiative, Clinical Research, Mental Health, Attention Deficit Hyperactivity Disorder (ADHD), 2.3 Psychological, social and economic factors, Aetiology, Quality Education, Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Child, Educational Status, Emotions, Employment, Family, Female, Follow-Up Studies, Humans, Income, Intelligence, Male, Young Adult, attention-deficit/hyperactivity disorder, adult outcomes, functioning, Multimodal Treatment Study of ADHD study, childhood predictors, MTA Cooperative Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Paediatrics, Applied and developmental psychology
Abstract

ObjectiveRecent results from the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (ADHD; MTA) have demonstrated impairments in several functioning domains in adults with childhood ADHD. The childhood predictors of these adult functional outcomes are not adequately understood. The objective of the present study was to determine the effects of childhood demographic, clinical, and family factors on adult functional outcomes in individuals with and without childhood ADHD from the MTA cohort.MethodRegressions were used to determine associations of childhood factors (age range 7-10 years) of family income, IQ, comorbidity (internalizing, externalizing, and total number of non-ADHD diagnoses), parenting styles, parental education, number of household members, parental marital problems, parent-child relationships, and ADHD symptom severity with adult outcomes (mean age 25 years) of occupational functioning, educational attainment, emotional functioning, sexual behavior, and justice involvement in participants with (n = 579) and without (n = 258) ADHD.ResultsPredictors of adult functional outcomes in ADHD included clinical factors such as baseline ADHD severity, IQ, and comorbidity; demographic factors such as family income, number of household members and parental education; and family factors such as parental monitoring and parental marital problems. Predictors of adult outcomes were generally comparable for children with and without ADHD.ConclusionChildhood ADHD symptoms, IQ, and household income levels are important predictors of adult functional outcomes. Management of these areas early on, through timely treatments for ADHD symptoms, and providing additional support to children with lower IQ and from households with low incomes, could assist in improving adult functioning.

Published
2017

14. Functional Adult Outcomes 16 Years After Childhood Diagnosis of Attention-Deficit/Hyperactivity Disorder: MTA Results

Author

Hechtman, Lily, Swanson, James M, Sibley, Margaret H, Stehli, Annamarie, Owens, Elizabeth B, Mitchell, John T, Arnold, L Eugene, Molina, Brooke SG, Hinshaw, Stephen P, Jensen, Peter S, Abikoff, Howard B, Algorta, Guillermo Perez, Howard, Andrea L, Hoza, Betsy, Etcovitch, Joy, Houssais, Sylviane, Lakes, Kimberley D, Nichols, J Quyen, Group, MTA Cooperative, Vitiello, Benedetto, Severe, Joanne B, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Elliott, Glen R, Wells, Karen C, Epstein, Jeffery N, Murray, Desiree W, Conners, C Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P, Greenhill, Laurence L, Newcorn, Jeffrey H, Molina, Brooke, Pelham, William E, Gibbons, Robert D, Marcus, Sue, Hur, Kwan, Kraemer, Helena C, Hanley, Thomas, and Stern, Karen

Subjects
Clinical and Health Psychology, Psychology, Clinical Research, Brain Disorders, Attention Deficit Hyperactivity Disorder (ADHD), Substance Misuse, Pediatric, Mental Health, Behavioral and Social Science, Aetiology, 2.3 Psychological, social and economic factors, Mental health, Good Health and Well Being, Adolescent, Adult, Aftercare, Attention Deficit Disorder with Hyperactivity, Child, Disease Progression, Employment, Female, Humans, Male, Substance-Related Disorders, Young Adult, ADHD, adult outcomes, follow-up, MTA, functional outcomes, MTA Cooperative Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Paediatrics, Applied and developmental psychology
Abstract

ObjectiveTo compare educational, occupational, legal, emotional, substance use disorder, and sexual behavior outcomes in young adults with persistent and desistent attention-deficit/hyperactivity disorder (ADHD) symptoms and a local normative comparison group (LNCG) in the Multimodal Treatment Study of Children with ADHD (MTA).MethodData were collected 12, 14, and 16 years postbaseline (mean age 24.7 years at 16 years postbaseline) from 476 participants with ADHD diagnosed at age 7 to 9 years, and 241 age- and sex-matched classmates. Probands were subgrouped on persistence versus desistence of DSM-5 symptom count. Orthogonal comparisons contrasted ADHD versus LNCG and symptom-persistent (50%) versus symptom-desistent (50%) subgroups. Functional outcomes were measured with standardized and demographic instruments.ResultsThree patterns of functional outcomes emerged. Post-secondary education, times fired/quit a job, current income, receiving public assistance, and risky sexual behavior showed the most common pattern: the LNCG group fared best, symptom-persistent ADHD group worst, and symptom-desistent ADHD group between, with the largest effect sizes between LNCG and symptom-persistent ADHD. In the second pattern, seen with emotional outcomes (emotional lability, neuroticism, anxiety disorder, mood disorder) and substance use outcomes, the LNCG and symptom-desistent ADHD group did not differ, but both fared better than the symptom-persistent ADHD group. In the third pattern, noted with jail time (rare), alcohol use disorder (common), and number of jobs held, group differences were not significant. The ADHD group had 10 deaths compared to one death in the LNCG.ConclusionAdult functioning after childhood ADHD varies by domain and is generally worse when ADHD symptoms persist. It is important to identify factors and interventions that promote better functional outcomes.

Published
2016

15. Childhood Factors Affecting Persistence and Desistence of Attention-Deficit/Hyperactivity Disorder Symptoms in Adulthood: Results From the MTA

Author

Roy, Arunima, Hechtman, Lily, Arnold, L Eugene, Sibley, Margaret H, Molina, Brooke SG, Swanson, James M, Howard, Andrea L, Group, MTA Cooperative, Vitiello, Benedetto, Severe, Joanne B, Jensen, Peter S, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P, Elliott, Glen R, Wells, Karen C, Epstein, Jeffery N, Murray, Desiree W, Conners, C Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P, Abikoff, Howard B, Greenhill, Laurence L, Newcorn, Jeffrey H, Molina, Brooke, Hoza, Betsy, Pelham, William E, Gibbons, Robert D, Marcus, Sue, Hur, Kwan, Kraemer, Helena C, Hanley, Thomas, and Stern, Karen

Subjects
Clinical and Health Psychology, Psychology, Brain Disorders, Mental Health, Prevention, Attention Deficit Hyperactivity Disorder (ADHD), Pediatric, Clinical Research, Behavioral and Social Science, Pediatric Research Initiative, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Good Health and Well Being, Adult, Attention Deficit Disorder with Hyperactivity, Child, Child of Impaired Parents, Disease Progression, Female, Follow-Up Studies, Humans, Male, Mental Disorders, Parents, Severity of Illness Index, attention-deficit/hyperactivity disorder, adulthood, family, comorbidity, IQ, MTA Cooperative Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Paediatrics, Applied and developmental psychology
Abstract

ObjectiveTo determine childhood factors that predict attention-deficit/hyperactivity disorder (ADHD) persistence and desistence in adulthood.MethodRegression analyses were used to determine associations between childhood factors and adult ADHD symptom persistence in 453 participants (mean age, 25 years) from the Multimodal Treatment Study of Children with ADHD (MTA). Childhood IQ, total number of comorbidities, child-perceived parenting practices, child-perceived parent-child relationships, parental mental health problems, marital problems of parents, household income levels, and parental education were assessed at a mean age of 8 years in all participants. Adult ADHD persistence was defined using DSM-5 symptom counts either with or without impairment, as well as mean ADHD symptom scores on the Conners' Adult ADHD Rating Scale (CAARS). Age, sex, MTA site, and childhood ADHD symptoms were covaried.ResultsThe most important childhood predictors of adult ADHD symptom persistence were initial ADHD symptom severity (odds ratio [OR] = 1.89, standard error [SE] = 0.28, p = .025), comorbidities (OR = 1.19, SE = 0.07, p = .018), and parental mental health problems (OR = 1.30, SE = 0.09, p = .003). Childhood IQ, socioeconomic status, parental education, and parent-child relationships showed no associations with adult ADHD symptom persistence.ConclusionInitial ADHD symptom severity, parental mental health, and childhood comorbidity affect persistence of ADHD symptoms into adulthood. Addressing these areas early may assist in reducing adult ADHD persistence and functioning problems.

Published
2016

16. Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study

Author

Vita, Giuseppe, Rizzo, Vincenzo, Russo, Massimo, Mazzeo, Anna, Gentile, Luca, Berk, John L, Brueckner, Caitlin, Lazzari, Victoria, Wiesman, Janice, DeLong, Douglas, Victory, Jennifer, Dalton, James, May, John, Gilmore, Catherine, Attarian, Shahram, Diallo, Saran, Delmont, Emilien, Pouget, Jean, Verschueren, Annie, Grapperon, Aude-Marie, Campana-Salort, Emmanuelle, Conceição, Isabel M, Lopes, Ana, Lamas, Filipa, Neves, Carlos, Castro, Jose, Pereira, Pedro, Castro, Isabel, Franco, Ana, Santos, Miguel Oliveira, de Azevedo Coutinho, Conceição, Falcao de Campos, Catarina, Coelho, Teresa, Hipólito Reis, Antonio, Correia, Nuno, Perez, Javier M, Martins da Silva, Ana, Alves, Cristina, Cardoso, Marcio, Valdrez, Katia, Monte, Julia R, Pessoa, Bernardete, Guimaraes, Nadia, Freitas, Monica, Ramalho, Joana, Ferreira, Natalia, Kuzume, Daisuke, Tard, Celine, Waucquier, Nawal, Rougeaux, Isabelle, Brice, Sylvie, Kasprzyk, Emmanuelle, Elrezzi, Elise, Meguig, Sayah, Hachulla, Eric, Gauvain, Clement, Migaud-Chervy, Maria-Claire, Deplanque, Dominique, Jozefowicz, Elsa, Lebellec, Loic, Adams, David, Balaya-Gouraya, Line, Jehan Lacour, Nathalie, Bournane, Halima, Martin, Nathalie, Elabed, Mongia, Sacko, Niamey, Boubrit, Yasmine, Gaouar, Amina, Rakotondratafika, Fetra, Théaudin-Saliou, Marie, Cauquil-Michon, Cécile, Labeyrie, Celine, Not, Adeline, Al-Salameh, Abdallah, Lecoq, Anne-Lise, Stephant, Maeva, Echaniz-Laguna, Andoni, Becquemont, Laurent, Beaudonnet, Guillemette, Algalarrondo, Vincent, Eliahou, Ludivine, Slama, Michel S, Rousseau, Antoine, Signate, Aissatou, Berthelot, Emeline, Inamo, Jocelyn, Planté-Bordeneuve, Violaine, Vervoitte, Laetitia, Focseneanu, Cecile, Gendre, Thierry, Arrouasse, Raphaele, Ayache, Samar S., Ernande, Laura, Le Corvoisier, Philippe, Salhi, Hayet, Choumert, Ariane, Ehinger, Vincent, Ruiz, Julie, Charlin, Cyril, Megelin, Thomas, Brannagan III, Thomas H, Fayerman, Raisy, Kim, Arreum, Paras, Allan, Gonzalez, Leidy J, Tsang, Steven, Wajnsztajn, Fernanda, Shije, Jeffrey, Ulane, Christina, Kleyman, Inna, Weimer, Louis, Cioroiu, Comana, Lambrianides, Sakis, Abu-Manneh, Rana, Zamba-Papanicolaou, Eleni, Agathangelou, Petros, Leonidou, Eleni, Tada, Satoshi, Fujita, Akemi, Nagai, Masahiro, Ando, Rina, Hosokawa, Yuko, Yamanishi, Yuki, Overcash, J. Scott, Giardino, Elena, Boyer, Leslie, Dang, Lien, Le, An, Nguyen, Tyler, Giang, Lien, Sellers, Peter, Tran, Leyla, Truong, Nghi, Vinas, Maita, Hrkman, Nicole, Miller, Sarah, Nguyen, David, Smith, Ashley, Pu, Helen, Li, Steve, Vuong, Thao, Dioso, Holly, Green, Sinikka, Lee, Kia, Chu, Hanh, Waters, Michael, Coskun, Derya J, Zepeda, Karla A, O'Riordan, William, Obici, Laura, Cortese, Andrea, Lozza, Alessandro, Merlini, Giampaolo, Rosti, Vittorio, Sabatelli, Mario, Bisogni, Giulia, Bernardo, Daniela, Luigetti, Marco, Di Paolantonio, Andrea, Guglielmino, Valeria, Romano, Angela, Nienhuis, Hans, Bulthuis-Kuiper, Janita, Kristen, Arnt V, Gerk, Olga, Ulbricht, Hannah, Taylor, Lenka, Meyle, Eva, Kleinschmidt, Natalia, Meyrath, David, Noe-Schwenn, Simone, Meng, Ulrike, Bauer, Ralf, aus dem Siepen, Fabian, Hein, Selina, Takahashi, Tetsuya, Oshita, Tomohiko, Koujin, Yoko, Neshige, Shuichiro, Nezu, Tomohisa, Segawa, Akiko, Ueno, Hiroki, Morino, Hiroyuki, Campistol, Josep M, Rodas Marin, Lida Maria, Blasco Pelicano, Josep Miquel, Dávila, Lucía Galán, Palacios, Marta, Pytel Cordoba, Vanesa, Guerrero Sola, Antonio, Horga, Alejandro, García Feijoo, Julián, Perez de Isla, Leopoldo, Marques Júnior, Wilson, Moscardini, Mariana, Litcanov, Debora Cristina, Viera Lima, Ana Flavia, Rodrigues, Leonardo, Marques Coutinho, Barbara, Moreira, Carolina Lavigne, Daccach Marques, Vanessa, Munoz Beamud, Francisco, Gragera Martínez, Álvaro, Borrachero, Cristina, Losada López, Inés Asunción, Cisneros Barroso, Eugenia, Rodríguez Rodríguez, Adrián, Sanz, Monica, Rigo Oliver, Elena, González Moreno, Juan, Gamez Martinez, Jose M, Descals, Cristina, Uson, Mercedes, Jose Vega, Francisco, Figuerola, Antoni, Montala, Carles, Waddington-Cruz, Márcia, Dias da Silva, Moises, Gervais de Santa Rosa, Renata, Pinto, Luiz Felipe, Pinto, Marcus Vinicius, Cardoso Berensztejn, Amanda, Barroso, Fabio, Lautre, Andrea, Orellana, Lucas G, González-Duarte Briseño, Maria Alejandra, Cárdenas-Soto, Karla, Jiménez López, Brenda Poled, Pérez-Castañeda, Sandra Lorena, Cantú Brito, Carlos Gerardo, Rivera de la Parra, David, Hernandez Reyes, Jose Pablo, del Mar Saniger Alba, Maria, Criollo Mora, Elia, Parman, Yesim, Rezzan, Kus Jülide, Sahin, Erdi, Serbest, Nail G, Durmus, Hacer, Cakar, Arman, Tugal Tutkun, Nuriye Ilknur, Karamursel, Sacit, Elitok, Ali, Sirin Inan, Nermin G, Altinkurt, Emre, Polydefkis, Michael, Ye, Jing, Allen, Adriane C, Chaudhry, Vinay, Jarrett, Raquel, Bressler, Neil, Burks, Kathleen L, Liu, Qingfeng, Khoshnoodi, Mohammad, Judge, Daniel P, Vista, Geno, Shah, Syed Mahmood, Hamaguchi, Hirotoshi, Oda, Junko, Fukase, Emi, Taniguchi, Ikuko, Oda, Tetsuya, Endo, Hironobu, Shimomura, Masahiro, Katanazaka, Kimitaka, Koto, Shusuke, Nakano, Takahiro, Scheid, Christof, Zueiter, Andreas, Pester, Lars, Walter, Doreen, Özdemir, Betül, Frenzel, Lukas F, Holtick, Udo, Oh, Jeeyoung, Kim, Hee Jin, Shin, Hyun Jin, Choi, Kyomin, Yamashita, Taro, Ueda, Mitsuharu, Masuda, Teruaki, Misumi, Yohei, Ueda, Akihiko, Nakahara, Keiichi, Yorita, Akiko, Tsuruhisa, Seiko, Taniwaki, Takayuki, Harada, Masaya, Moritaka, Taiga, Sakurada, Naonori, Mauricio, Elizabeth A, Baskin, Amber, Dimberg, Elliot, Dispenzieri, Angela, Fonder, Amie, Hobbs, Miriam, Russell, Stephen J, Dyck, Peter, Gonsalves, Wilson, Leung, Nelson, Witzig, Thomas E, Zeldenrust, Steven R, Hwa, Lisa, Kapoor, Prashant, Kumar, Shaji K, Lin, Yi, Lust, John A, Rajkumar, Vincent S, Dingli, David, Gertz, Morie A, Go, Ronald, Hayman, Suzanne R, Dalia, Samir, Carrillo, Esmeralda, Gorevic, Peter, Mason, Garnette, Chao, Chi-Chao, Lee, Ming-Jen, Su, Jen-Jen, Hsieh, Sung-Tsang, Tsai, Li-Kai, Yeh, Shin-Joe, Yang, Chih-Chao, Ajroud-Driss, Senda Ajroud-Driss, Casey, Patricia, Joslin, Benjamin C, Freimer, Miriam, Sankey, Alison, Kenepp, Amanda, Heintzman, Sarah, LoRusso, Samantha, Hokezu, Youichi, Kim, Byoung-Joon, Kim, JuHyeon, Lee, Ga Yeon, Cho, Eun Bin, Jeon, Eun-Seok, Min, Ju-Hong, Seok, Jin Myoung, Lee, Hye Lim, Park, Jae Hong, Sekijima, Yoshiki, Miyazawa, Chinatsu, Kato, Nagaaki, Kishida, Dai, Hineno, Akiyo, Kodaira, Minori, Yoshinaga, Tsuneaki, Miyahara, Teruyoshi, Imai, Akira, Matsumoto, Kazuhiko, Lin, Kon-Ping, Lee, Yi-Chung, Wixner, Jonas, Falk, Malin, Pilebro, Bjorn, Suhr, Ole, Lindqvist, Per, Soderberg, Karin, Pedrosa-Domellöf, Fatima, Anan, Intissar, Nordh, Erik, Tournev, Ivaylo, Zhelyazkova-Glaveeva, Sashka, Cherneva, Zheyna, Sarafov, Staiko, Chamova, Teodora, Cherninkova-Gopina, Sylvia, Schmidt, Hartmut H, Friebel, Frauke, Zibert, Andree, Mihailovic, Natasa, Schubert, Friederike, Vorona, Elena, Lahme, Larissa, Huesing-Kabar, Anna, Schilling, Matthias, Kabar, Iyad, Gillmore, Julian D, Martinez-Naharro, Ana, Chacko, Liza, Cohen, Oliver, Law, Steven, Rezk, Tamer, Lachmann, Helen J, Quan, Dianna, Blume, Brianna, Dixon, Stacy, Low, Soon Chai, Chan, Soo Looi, Lim, He Eng Li, Goh, Khean Jin, Mezei, Michelle M, Kraus, Deborah, Jack, Kristin, Wade, N. Kevin, Lopate, Glenn, Zwijack, Brittany, Florence, Julaine, Sommerville, R. Brian, Stewart, Graeme, Ryder, Julie, Mekhael, Linda, Taylor, Mark, Suan, Daniel, Wells, Karen, Stone, Paula, Itoya, Amenze, Owusu-Sekyere, Mercy, Thai, Desmond, Chahine, Ilonah, Pedrosa, Salve, Do, Thi Hoa (Therese), González-Duarte, Alejandra, Kyriakides, Theodoros, Ajroud-Driss, Senda, Mauricio, Elizabeth, Brannagan, Thomas H, III, Aldinc, Emre, Wang, Jing Jing, White, Matthew T, Vest, John, Berber, Erhan, and Sweetser, Marianne T

Published
2021
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17. Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study

Author

Achten, Niek, Ainsworth, John, Akkerman, Nonna, Anderson, Elizabeth, Anderson, Larry J., Andrews, Howard, Armagost, Elizabeth, Aubuchon, Mary Ann, Bach, Julia, Bacharier, Leonard, Barnes, Kathrine L., Barone, Charles, Bauer, Irma, Beamer, Paloma, Becker, Patrice, Bednarek, Alyssa, Bellemore, Stacey, Bendixsen, Casper G., Biagini Myers, Jocelyn M., Billheimer, Dean, Billstrand, Christine, Birg, Geraldine, Blocki, Shirley, Bloomberg, Gordon, Bobbitt, Kevin, Bochkov, Yury, Bourgeois, Karen, Boushey, Homer, Brockman-Schneider, Rebecca, Brunwasser, Steven M., Budrevich, Richard, Burkle, Jeffrey W., Busse, William, Calatroni, Agustin, Campbell, Janice, Carlson-Dakes, Kirsten, Cassidy-Bushrow, Andrea, Chappell, James D., Chasman, Deborah, Chipps, Teresa M., Chirkova, Tatiana, Cole, Deanna, Connolly, Alexandra, Cootauco, Michelle, Costello, Kaitlin, Couch, Philip, Coull, Brent, Craven, Mark, Crisafi, Gina, Cruikshank, William, Curtsinger, Kristi, Custovic, Adnan, Das, Suman R., DaSilva, Douglas, Datta, Soma, Davidson, Brent, De La Ossa, Lydia, DeVries, Mark, Di, Qian, Dixon, Samara, Donnerbauer, Erin, Dorst, Marian, Doyle, Susan, Dresen, Amy, Dupont, William D., Durrange, Janet, Erickson, Heidi, Evans, Michael D., Ezell, Jerel, Farnham, Leanna, Filardo-Collins, Roxanne, Finazzo, Salvatore, Flege, Zachary, Fleurat, Conner, Floerke, Heather, Floerke, Dorothy, Foss, Terry, Freie, Angela, Frome, Wayne, Fye, Samantha, Gagalis, Lisa, Gammell, Rebecca, Gangnon, Ronald E., Ge, James E., Gebretsadik, Tebeb, Gergen, Peter, Gern, James E., Gibson, Heike, Gjerasi, Edlira, Gold, Diane R., Gonzalez, Nicole, Goodman, Kayla, Gress, Lisa, Grindle, Kristine, Groeschen, Taylor, Hallmark, Brian, Halonen, Marilyn, Hart, Jaime, Hartert, Tina V., Havstad, Suzanne, Heinritz, Patrick, Hensley Alford, Sharon, Herbstman, Julie, Hernandez, Kellie, Hoepner, Lori, Jackson, Daniel J., Jadhao, Samadhan J., Jaffee, Katy, James, Peter, Jezioro, Jacqueline, Jimenez Pescador, Marcia, Johnson, Christine C., Johnson, Tara, Johnson, Camille, Jones, Amelia, Jones, Kyra, Jones, Paul, Jordan, Carolina, Joseph, Christine LM, Kattan, Meyer, Keidel, Kristina, Keifer, Matthew C., Kelley, Rick, Khurana Hershey, Gurgit K., Kim, Haejin, Kloog, Itai, Koepel, Tammy Kronenwetter, Koerkenmeier, Clint, Ladick, Laura, Lamm, Carin, Larkin, Emma, Lederman, Howard, Lee-Parritz, Aviva, Leimenstoll, Stephanie, Lemanske, Jr., Robert F., LeMasters, Grace K., Levin, Albert M., Levine, Jessica, Liu, Xinhua, Liu, Zhouwen, Lopez, Silvia, Lothrop, Nathan, Lovinsky-Desir, Stephanie, Lukacs, Nicholas, Lynch, Susan, Lynch, Christian, Mann, Erik, Martin, Jennifer, Martin, Lisa, Martinez, Fernando D., Matsui, Elizabeth, McCauley, Katherine, Mccollum, Megan, McCullough, Judith, McKennon, Chris G., Meece, Jennifer, Mendonca, Eneida, Mikus, Lance, Miller, Rachel L., Minton, Patricia, Mitchell, Herman, Moon, Vicki, Moore, Paul E., Morgan, Wayne, Morgan, Valerie, Morgan, David, Murrison, Liza, Nicholas, Charlotte, Nicolae, Daniel, Nunez, Adam, O'Connor, George, O'Toole, Sharon, Ober, Carole, Olson, Brent F., Ong, Irene, Osmundson, Sarah, Ownby, Dennis, Pappas, Tressa, Perera, Frederica, Perzanowski, Matthew, Peterson, Edward, Pierce, Marcela, Price-Johnson, Penny, Rajamanickam, Victoria, Ramirez, Judyth, Ray, Kimberly, Renneberg, Megan, Requia, Weeberb, Riley, Kylie, Rivera, Janelle, Rivers, Neisha, Roberg, Kathy, Rogers, Theresa, Rosas-Salazar, Christian, Russell, Pat, Ryan, Patrick H., Sadovsky, Yoel, Salazar, Lisa, Sampson, Hugh, Sandel, Megan, Schoettler, Nathan, Schwartz, Joel, Scott, Dena, Seroogy, Christine M., Sharp, Renee, Shilts, Meghan H., Sigelman, Steve, Singh, Anne Marie, Sitarik, Alexandra, Smartt, Ernestine, Sorkness, Ronald, Sorkness, Christine, Spangenberg, Amber, Sperling, Rhoda, Spies, David, Stern, Debra A., Stoffel, Brandy, Peebles, R. Stokes, Stouffer, Gina, Strauchman Boyer, Cathey, Suddeuth, Caitlin, Tachinardi, Umberto, Tang, Deliang, Tang, Zhengzheng, Tate, Jena, Taylor, William, Tensing, Krista, Tesson, Elizabeth, Thompson, Kathy, Thompson, Emma, Tisler, Christopher, Togias, Alkis, Turi, Kedir, Turner, Victoria, Tuzova, Marina, VanWormer, Jeffrey J., Visness, Cynthia M., Vrtis, Rose, Wahlman, Anthony, Wang, Lena, Wegienka, Ganesa, Wells, Karen, Wentworth-Sheilds, William, Wheatley, Lisa, Whitney, Nitsa, Williams, L. Keoki, Witter, Frank, Wolfe, Christopher, Wood, Robert A., Woodcroft, Kimberley, Woodward, Kim B., Wright, Anne L., Wright, Rosalind, Wu, Pingsheng, Yaeger, Melissa, Yaniv, Perri, Zanobetti, Antonella, Zhang, Shirley, Zook, Patricia, Zoratti, Edward M., McKennan, Chris G, Magnaye, Kevin M, Altman, Matthew C, Washington, Charles, 3rd, Stanhope, Catherine, Naughton, Katherine A, Rosasco, Mario G, Bacharier, Leonard B, Gold, Diane R, Hartert, Tina, Khurana Hershey, Gurjit K, Hogarth, D Kyle, Jackson, Daniel J, Johnson, Christine C, Lemanske, Robert F, Lynch, Susan V, Mendonca, Eneida A, Miller, Rachel L, Naureckas, Edward T, O'Connor, George T, Seroogy, Christine M, White, Steven R, Wood, Robert A, Wright, Anne L, Zoratti, Edward M, Martinez, Fernando D, Nicolae, Dan L, Levin, Albert M, and Gern, James E

Published
2020
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20. Nocturnal Asthma and the Importance of Race/Ethnicity and Genetic Ancestry

Author

Levin, Albert M, Wang, Yun, Wells, Karen E, Padhukasahasram, Badri, Yang, James J, Burchard, Esteban G, and Williams, L Keoki

Subjects
Clinical Research, Lung, Asthma, Genetics, Human Genome, Respiratory, Administration, Inhalation, Adult, African Americans, Albuterol, Body Mass Index, Bronchodilator Agents, Circadian Rhythm, Female, Forced Expiratory Volume, Genome-Wide Association Study, Humans, Logistic Models, Male, Michigan, Pharmacogenetics, Phenotype, Smoking, Surveys and Questionnaires, Whites, asthma, nocturnal symptoms, race/ethnicity, lung function, genetic ancestry, White People, Black or African American, Medical and Health Sciences, Respiratory System
Abstract

RationaleNocturnal asthma is a common presentation and is associated with a more severe form of the disease. However, there are few epidemiologic studies of nocturnal asthma, particularly in minority populations.ObjectivesTo identify factors associated with nocturnal asthma, including the contribution of self-identified race/ethnicity and genetic ancestry.MethodsThe analysis included individuals from the Study for Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE) cohort. Nocturnal asthma symptoms were assessed by questionnaire. Genome-wide genotype data were used to estimate genetic ancestry in a subset of African American participants. Logistic regression was used evaluate the association of various factors with nocturnal asthma, such as self-identified race/ethnicity and genetic ancestry.Measurement and main resultsThe study comprised 3,380 African American and 1,818 European Americans individuals with asthma. After adjusting for other potential explanatory variables, including controller medication use, African Americans were more than twice as likely (odds ratio, 2.56; 95% confidence interval, 2.24-2.93) to report nocturnal asthma when compared with European American individuals. Among the subset of African American participants with genome-wide genotype data (n = 1,040), estimated proportion of African ancestry was also associated with an increased risk of nocturnal asthma (P = 0.007). Differences in lung function explained a small, but statistically significant (P = 0.02), proportion of the relationship between genetic ancestry and nocturnal asthma symptoms.ConclusionsBoth self-identified race/ethnicity and African ancestry appear to be independent predictors of nocturnal asthma. The mechanism by which genetic ancestry contributes to population-level differences in nocturnal asthma appears to be largely independent of lung function.

Published
2014

22. Serum cholesterol trajectories in the 10 years prior to lymphoma diagnosis

Author

Cancer Research Network Lymphoma Study Group, Alford, Sharon Hensley, Divine, George, Chao, Chun, Habel, Laurel A., Janakiraman, Nalini, Wang, Yun, Feigelson, Heather Spencer, Scholes, Delia, Roblin, Doug, Epstein, Mara M., Engel, Lawrence, Havstad, Suzanne, Wells, Karen, Yood, Marianne Ulcickas, Fortuny, Joan, and Johnson, Christine Cole

Published
2018

24. Adolescent Substance Use in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (ADHD) (MTA) as a Function of Childhood ADHD, Random Assignment to Childhood Treatments, and Subsequent Medication

Author

Molina, Brooke S.G., Hinshaw, Stephen P., Arnold, L. Eugene, Swanson, James M., Pelham, William E., Hechtman, Lily, Hoza, Betsy, Epstein, Jeffery N., Wigal, Timothy, Abikoff, Howard B., Greenhill, Laurence L., Jensen, Peter S., Wells, Karen C., Vitiello, Benedetto, Gibbons, Robert D., Howard, Andrea, Houck, Patricia R., Hur, Kwan, Lu, Bo, and Marcus, Sue

Abstract

ObjectivesTo determine long-term effects on substance use and substance use disorder (SUD), up to 8 years after childhood enrollment, of the randomly assigned 14-month treatments in the multisite Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (MTA; n=436); to test whether (a) medication at follow-up, (b) cumulative psychostimulant treatment over time, or (c) both relate to substance use/SUD; to compare substance use/SUD in the ADHD sample to the non-ADHD childhood classmate comparison group (n=261).MethodMixed-effects regression models with planned contrasts were used for all tests except the important cumulative stimulant treatment question, for which propensity score matching analysis was used.ResultsThe originally randomized treatment groups did not differ significantly on substance use/SUD by the 8 year follow-up or earlier (M age = 17 years). Neither medication at follow-up (mostly stimulants) nor cumulative stimulant treatment was associated with adolescent substance use/SUD. Substance use at all time points, including use of two or more substances and SUD, were each greater in the ADHD than non-ADHD samples, regardless of sex.ConclusionsMedication for ADHD did not protect from, nor contribute to, visible risk of substance use or SUD by adolescence, whether analyzed as randomized treatment assignment in childhood, as medication at follow-up, or as cumulative stimulant treatment over an 8 year follow-up from childhood. These results suggest the need to identify alternative or adjunctive adolescent-focused approaches to substance abuse prevention and treatment for boys and girls with ADHD, especially given their increased risk for use and abuse of multiple substances that is not improved with stimulant medication. Clinical trial registration information—Multimodal Treatment Study of Children with Attention Deficit and Hyperactivity Disorder (MTA); http://clinical trials.gov/; NCT00000388.

Published
2013

25. Genetic ancestry and its association with asthma exacerbations among African American subjects with asthma

Author

Rumpel, Jennifer A, Ahmedani, Brian K, Peterson, Edward L, Wells, Karen E, Yang, Mao, Levin, Albert M, Yang, James J, Kumar, Rajesh, Burchard, Esteban González, and Williams, L Keoki

Subjects
Biomedical and Clinical Sciences, Immunology, Asthma, Prevention, Lung, Clinical Research, Genetics, Respiratory, Adolescent, Adult, Black or African American, Aged, Child, Disease Progression, Emergency Service, Hospital, Female, Hospitalization, Humans, Insurance Claim Review, Male, Middle Aged, Risk, Sex Factors, United States, Young Adult, continental population groups, African continental ancestry group, genetic association study, health status disparities, minority health, Allergy
Abstract

BackgroundThere are large and persisting disparities in severe asthma exacerbations by race-ethnicity, and African American subjects are among those at greatest risk. It is unclear whether this increased risk solely represents differences in environmental exposures and health care or whether there is a predisposing genetic component.ObjectiveWe sought to assess the relationship between genetic ancestry and severe exacerbations among African American subjects with asthma.MethodsParticipants were part of the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE). These subjects were 12 to 56 years of age, received care from a single large health system, and had a physician's diagnosis of asthma. Genetic ancestry was estimated by using a set of validated ancestry informative markers. Severe exacerbations (ie, asthma-related emergency department visits, hospitalizations, and burst oral steroid use) were prospectively identified from health care claims.ResultsWe assessed genetic ancestry in 392 African American subjects with asthma. The average proportion of African ancestry was 76.1%. A significant interaction was identified between ancestry and sex on severe exacerbations, such that the risk was significantly higher with increasing African ancestry among male but not female subjects. The association among male subjects persisted after adjusting for potential confounders (relative rate, 4.30 for every 20% increase in African ancestry; P = .029).ConclusionsAfrican ancestry was significantly and positively associated with severe exacerbations among male African American subjects. These findings suggest that a portion of the risk of asthma exacerbations in this high-risk group is attributable to a genetic risk factor that partitions with ancestry.

Published
2012

30. Childhood Predictors of Adult Functional Outcomes in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (MTA)

Author

Vitiello, Benedetto, Severe, Joanne B., Jensen, Peter S., Arnold, L. Eugene, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P., Elliott, Glen R., Wells, Karen C., Epstein, Jeffery N., Murray, Desiree W., Conners, C. Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P., Abikoff, Howard B., Hechtman, Lily, Greenhill, Laurence L., Newcorn, Jeffrey H., Molina, Brooke, Hoza, Betsy, Pelham, William E., Gibbons, Robert D., Marcus, Sue, Hur, Kwan, Kraemer, Helena C., Hanley, Thomas, Stern, Karen, Roy, Arunima, Swanson, James M., Molina, Brooke S.G., Sibley, Margaret H., and Howard, Andrea L.

Published
2017
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32. Parental Aggression as a Predictor of Boys' Hostile Attribution across the Transition to Middle School

Author

Yaros, Anna, Lochman, John E., and Wells, Karen

Abstract

Aggression among youth is a public health problem that is often studied in the context of how youth interpret social information. Social cognitive factors, especially hostile attribution biases, have been identified as risk factors for the development of youth aggression, particularly across the transition to middle school. Parental behaviors, including parental aggression to children in the form of corporal punishment and other aggressive behavior, have also been linked to aggressive behavior in children at these ages. Despite the important role played by these two risk factors, the connection between the two has not been fully studied in the literature. This study examined the link between parental aggression and children's hostile attributions longitudinally among a diverse sample of 123 boys as they entered middle school. Results support acceptance of a model in which parental aggression to children prior to entering middle school predicted children's hostile attributions after the transition to middle school above and beyond that which was predicted by previous levels of hostile attributions. As expected, hostile attributions also predicted change in parent- and teacher-rated child aggression. These findings provide important evidence of the role that parental behavior plays in youth social cognition at this critical age, which has implications for understanding the development of aggressive behavior.

Published
2016
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33. Functional Adult Outcomes 16 Years After Childhood Diagnosis of Attention-Deficit/Hyperactivity Disorder: MTA Results

Author

Vitiello, Benedetto, Severe, Joanne B., Jensen, Peter S., Arnold, L. Eugene, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P., Elliott, Glen R., Wells, Karen C., Epstein, Jeffery N., Murray, Desiree W., Conners, C. Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P., Abikoff, Howard B., Hechtman, Lily, Greenhill, Laurence L., Newcorn, Jeffrey H., Molina, Brooke, Hoza, Betsy, Pelham, William E., Gibbons, Robert D., Marcus, Sue, Hur, Kwan, Kraemer, Helena C., Hanley, Thomas, Stern, Karen, Swanson, James M., Sibley, Margaret H., Stehli, Annamarie, Owens, Elizabeth B., Mitchell, John T., Molina, Brooke S.G., Perez Algorta, Guillermo, Howard, Andrea L., Etcovitch, Joy, Houssais, Sylviane, Lakes, Kimberley D., and Nichols, J. Quyen

Published
2016
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34. Childhood Factors Affecting Persistence and Desistence of Attention-Deficit/Hyperactivity Disorder Symptoms in Adulthood: Results From the MTA

Author

Vitiello, Benedetto, Severe, Joanne B., Jensen, Peter S., Arnold, L. Eugene, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P., Elliott, Glen R., Wells, Karen C., Epstein, Jeffery N., Murray, Desiree W., Conners, C. Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P., Abikoff, Howard B., Hechtman, Lily, Greenhill, Laurence L., Newcorn, Jeffrey H., Molina, Brooke, Hoza, Betsy, Pelham, William E., Gibbons, Robert D., Marcus, Sue, Hur, Kwan, Kraemer, Helena C., Hanley, Thomas, Stern, Karen, Roy, Arunima, Sibley, Margaret H., Molina, Brooke S.G., Swanson, James M., and Howard, Andrea L.

Published
2016
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35. International and domestic sources of state stability and regime collapse : merchant capital in Ethiopia, 1974-1995

Author

Wells, Karen

Subjects
320, Ethiopian, Derg, Nationalisation, Africa, Trade
Abstract

This thesis is an analysis of the interrelationship between international and domestic determinants of state action in Ethiopia in the period 1974 - 1995. It uses an historical materialist framework to show that the Ethiopian state acts to further the interests of domestic merchant capital, and that continuities between successive regimes express a deeper underlying continuity in the structures of the social formation. It discusses the ways in which land reform further entrenched peasants in their existing conditions of production, in response to which the Derg regime undertook to extend state interventions in trade. State involvement in trade has been crucial to the ability of successive regimes to preserve and expand state structures. The alliance with merchant capital which underpinned the state's role in trade explains the decision to nationalise industry. Nationalisation led to a decline in industrial production to the benefit of domestic merchant capital. However the dominance of merchant capital exists alongside low-levels of capital accumulation which renders the state dependent on external alliances and therefore makes regimes highly susceptible to changes at the international level. The low-level of development of the productive forces has retarded the integration of Ethiopia and strengthened regional identities. The resulting fragmentation of power has been an enduring theme of Ethiopian politics. These continuities in underlying structures have contributed to continuities in regime action at the level of the degree of state penetration, the formation of state revenues, and the military basis of regime legitimacy. Finally, it suggests that the model offered here, of a state supporting a domestic merchant class, may be useful in explaining the relationship between states and classes elsewhere in sub-Saharan Africa.

Published
1999

38. Serum cholesterol trajectories in the 10 years prior to lymphoma diagnosis

Author

Alford, Sharon Hensley, Divine, George, Chao, Chun, Habel, Laurel A., Janakiraman, Nalini, Wang, Yun, Feigelson, Heather Spencer, Scholes, Delia, Roblin, Doug, Epstein, Mara M., Engel, Lawrence, Havstad, Suzanne, Wells, Karen, Yood, Marianne Ulcickas, Fortuny, Joan, Johnson, Christine Cole, Achacoso, Ninah, Boudreau, Denise, Chen, Lie, Eide, Melody, Fraser, James, Hart, Gene, Koshiol, Jill, Preciado, Melissa, Ren, Junling, Sharafali, Zaineb, Spangler, Leslie, Tabano, David, Weston, Noah, Woodcroft, Kimberley, Wrenn, Michelle, and for the Cancer Research Network Lymphoma Study Group

Published
2017
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40. Long-term outcomes in the Multimodal Treatment study of Children with ADHD (the MTA)

Author

Swanson, James M., primary, Eugene Arnold, L., additional, Jensen, Peter S., additional, Hinshaw, Stephen P., additional, Hechtman, Lily T., additional, Pelham, William E., additional, Greenhill, Laurence L., additional, Keith Conners, C., additional, Kraemer, Helena C., additional, Wigal, Timothy, additional, Vitiello, Benedetto, additional, Elliott, Glen R., additional, Abikoff, Howard B., additional, Hoza, Betsy, additional, Newcorn, Jeffrey H., additional, Wells, Karen, additional, Lerner, Marc, additional, Molina, Brooke S. G., additional, Epstein, Jeffery N., additional, Owens, Elizabeth B., additional, Waxmonsky, James, additional, Murray, Desiree W., additional, Sibley, Margaret H., additional, Mitchell, John T., additional, and Roy, Arunima, additional

Published
2018
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42. Co‐design and evaluation of a multidisciplinary teaching resource on mental health recovery involving people with lived experience

Author

Arblaster, Karen, primary, Mackenzie, Lynette, additional, Buus, Niels, additional, Chen, Timothy, additional, Gill, Katherine, additional, Gomez, Lisa, additional, Hamilton, Deborah, additional, Hancock, Nicola, additional, McCloughen, Andrea, additional, Nicholson, Margaret, additional, Quinn, Yvette, additional, River, Jo, additional, Scanlan, Justin Newton, additional, Schneider, Carl, additional, Schweizer, Richard, additional, and Wells, Karen, additional

Published
2023
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43. Introduction

Author

Balagopalan, Sarada, primary, Wall, John, additional, and Wells, Karen, additional

Published
2023
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47. Volatilomics of raspberry fruit germplasm by combining chromatographic and direct-injection mass spectrometric techniques

Author

Farneti, Brian, Khomenko, Iuliia, Ajelli, Matteo, Wells, Karen Elizabeth, Betta, Emanuela, Aprea, Eugenio, Giongo, Lara, and Biasioli, Franco

Subjects
SPME-GC-MS, Rubus idaeus L., PTR-ToF-MS, SPME-GC-MS, germplasm, VOCs, phenotyping, quality, phenotyping, Rubus idaeus L, VOCs, germplasm, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, Quality, quality, Phenotyping, Germplasm, Settore AGR/03 - ARBORICOLTURA GENERALE E COLTIVAZIONI ARBOREE, Molecular Biology, PTR-ToF-MS
Abstract

The application of direct-injection mass spectrometric (DI-MS) techniques, like Proton Transfer Reaction Time of Flight Mass Spectrometry (PTR-ToF-MS) has been suggested as a reliable phenotyping tool for fruit volatilome assessment in both genetic and quality-related studies. In this study the complexity of raspberry aroma was investigated by a comprehensive untargeted VOC analysis, done by combining SPME-GC-MS and PTR-ToF-MS assessments with multi-block discriminant analysis using the DIABLO mixOmics framework. The aim was to acquire an exhaustive characterization of the raspberry volatilome according to different fruit ripening stages (pink, ripe, and overripe) and genetic variances (50 accessions), as well as to investigate the potential of PTR-ToF-MS as a rapid and high throughput VOC phenotyping tool to address issues related to raspberry fruit quality. Results of this study demonstrated the complementarity between SPME-GC-MS and PTR-ToF-MS techniques to evaluate the raspberry aroma composition. PTR-ToF-MS generates reliable raspberry VOC fingerprints mainly due to a reduced compound fragmentation and precise content estimation. In addition, the high collinearity between isomers of monoterpenes and norisoprenoids, discovered by GC analysis, reduces the main analytic limitation of PTR-ToF-MS of not being able to separate isomeric molecules. The high similarity between the VOC matrices obtained by applying PTR-ToF-MS and SPME-GC-MS confirmed the possibility of using PTR-ToF-MS as a reliable high throughput phenotyping tool for raspberry volatiolome assessment. In addition, results provided by the germplasm collection investigation enabled to distinguish the best performing accessions, based on VOCs composition, to be used as superior parental lines for future breeding programs.

Published
2023

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