2,357 results on '"Wen, Fan"'
Search Results
2. Non-intersective Dragon Curves
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Akiyama, Shigeki, Kamiya, Yuichi, and Wen, Fan
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Mathematics - Metric Geometry - Abstract
Let us fold a strip of paper many times in the same direction, and then unfold it so that all dents make a fixed angle $\theta$. The resulting shape is called the Dragon curve with the unfolding angle $\theta$. When $0\le\theta<90^{\circ}$, the corresponding Dragon curve has a self-intersection. When $\theta=180^{\circ}$, the corresponding Dragon curve is a straight line, which has no self-intersection. In this paper, we will show that any Dragon curve whose unfolding angle is greater than $99.3438^{\circ}$ and less than $180^{\circ}$ has no self-intersection.
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- 2024
3. Effects of spin-orbit coupling on gravitational waveforms from a triaxial non-aligned neutron star in a binary system
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Feng, Wen-Fan, Liu, Tan, Chen, Jie-Wen, Wang, Yan, and Mohanty, Soumya D.
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Spinning neutron stars (NSs) can emit continuous gravitational waves (GWs) that carry a wealth of information about the compact object. If such a signal is detected, it will provide us with new insight into the physical properties of matter under extreme conditions. Future space-based GW detectors, such as LISA and TianQin, can potentially detect some double NSs in tight binaries with orbital periods shorter than 10 minutes. The possibility of a successful directed search for continuous GWs from the spinning NS in such a binary system identified by LISA/TianQin will be significantly increased with the proposed next-generation ground-based GW observatories, such as Cosmic Explorer and Einstein Telescope. Searching for continuous GWs from such a tight binary system requires highly accurate waveform templates that account for the interaction of the NS with its companion. In this spirit, we derive analytic approximations that describe the GWs emitted by a triaxial non-aligned NS in a binary system in which the effects of spin-orbit coupling have been incorporated. The difference with the widely used waveform for the isolated NS is estimated and the parameter estimation accuracy of an example signal using Cosmic Explorer is calculated. For a typical tight double NS system with a 6~min orbital period, the angular frequency correction of the spinning NS in this binary due to spin precession is $\sim 10^{-6}~{\rm Hz}$, which is in the same order of magnitude as the angular frequency of orbital precession. The fitting factor between the waveforms with and without spin precession will drop to less than 0.97 after a few days ($\sim 10^5~{\rm s}$). We find that spin-orbit coupling has the potential to improve the accuracy of parameter estimation, especially for the binary inclination angle and spin precession cone opening angle, by up to 3 orders of magnitude. (Abridged), Comment: 17 pages, 9 figures. Match the version accepted by PRD
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- 2023
4. Formation processes and mechanisms of a fault-controlled colluvial landslide in the Qinling-Daba Mountains, China
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Wenbo Zheng, Yanbo Cao, Wen Fan, Xin Liang, Shaoqing Yuan, Wenwei Gao, and Jikai Zhang
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Fault-controlled landslide ,Hydrogeological structures ,Topography ,Formation process ,Failure mechanisms ,Medicine ,Science - Abstract
Abstract Faults play a crucial role in shaping the formation and damage patterns of landslides in the mountainous region, particularly in Qinling-Daba (Qinba) area in China. On 6 October 2022, following a 4-day rainfall event totaling 221.5 mm, a landslide occurred in Hanwang Town, Shaanxi Province. The left boundary of the landslide coincided with a fault, which influence the formation and movement development of the landslide. To further understand and quantified the formation process and damage mechanism of the landslide, a comprehensive study was conducted, incorporating field investigations, local rainfall data, and various methods including unmanned aerial vehicles (UAVs), numerical simulations, and laboratory test. The results indicate that fault dictate the formation of the Lijiaping landslide by influencing the mechanical strength of the rock mass and the catchment topography in the landslide area. Due to fault, the rock mass in the landslide area is high fragmentation, with a softening coefficient of about 0.52. Weathering resulted in numerous residual and slope sediments in the landslide area, providing ample material for the landslide. Meanwhile, the fault activity led to a wedge-shaped topography in the landslide area, with an average Terrain Wetness Index (TWI) of 3.43, significantly higher than the Hanwang Township average of 1.47. This creates a hydrogeological structure favorable for landslides. Numerical simulations revealed that the maximum velocity of the landslide reached 5.05 m/s and the maximum displacement was 53.18 m, both occurring in the central part of the landslide. These findings offer crucial scientific insights for understanding and preventing similar geological hazards.
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- 2024
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5. Oral microbiota diversity in moderate to severe plaque psoriasis, nail psoriasis and psoriatic arthritis
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Wen Fan, Na Lei, Yujie Zheng, Juan Liu, Xuechen Cao, Ting Su, Zhonglan Su, and Yan Lu
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Plaque psoriasis ,Psoriatic arthritis ,16S rRNA sequencing ,Oral microbiota ,Prevotella ,Corynebacterium ,Medicine ,Science - Abstract
Abstract Gaining a comprehensive understanding of the role played by the oral microbiome in moderate to severe plaque psoriasis and its potential implications for disease management and development holds significant importance. With the objective of exploring correlations between the oral microbiota and severe psoriasis, this study involved 72 severe psoriasis patients and 16 healthy individuals, whose clinical manifestations and living habits were carefully recorded. Cutting-edge techniques such as 16S rRNA gene sequencing and bioinformatics analysis were employed to compare the microbial flora, investigating dynamic changes among severe plaque psoriasis patients, psoriatic arthritis patients and healthy individuals. The findings revealed noteworthy patterns including increased levels of Aggregatibacter in the psoriatic arthritis group, accompanied by a decrease in the level of Prevotella. Moreover, the enrichment o Capnocytandophaga (P = 0.009), Campylobacter (P = 0.0022), and Acetobacter (P = 0.0292) was notably more substantial in the psoriasis group compared to the control group, whereas certain bacterial species such as Bacteroides (P = 0.0049), Muribaculaceae (P = 0.0048) demonstrated decreased enrichment. Additionally, the psoriatic arthritis group exhibited significantly higher levels of Ralstonia, Bifidobacterium and Micromonospora. Based on these findings, it can be inferred that individuals with lower levels of Prevotella and higher levels of Corynebacterium may be more susceptible to psoriasis exacerbation.
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- 2024
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6. Multi-messenger observations of double neutron stars in Galactic disk with gravitational and radio waves
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Feng, Wen-Fan, Chen, Jie-Wen, Wang, Yan, Mohanty, Soumya D., and Shao, Yong
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Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology - Abstract
We evaluate the prospects for radio follow-up of the double neutron stars (DNSs) in the Galactic disk that could be detected through future space-borne gravitational wave (GW) detectors. We first simulate the DNS population in the Galactic disk that is accessible to space-borne GW detectors according to the merger rate from recent LIGO results. Using the inspiraling waveform for the eccentric binary, the average number of the DNSs detectable by TianQin (TQ), LISA, and TQ+LISA are 217, 368, and 429, respectively. For the joint GW detection of TQ+LISA, the forecasted parameter estimation accuracies, based on the Fisher information matrix, for the detectable sources can reach the levels of $\Delta P_{\mathrm b}/P_{\mathrm b} \lesssim 10^{-6}$, $\Delta \Omega \lesssim 100~{\mathrm {deg}}^2$, $\Delta e/e \lesssim 0.3$, and $\Delta \dot{P}_{\mathrm b} / \dot{P}_{\mathrm b} \lesssim 0.02$. These estimation accuracies are fitted in the form of power-law function of signal-to-noise ratio. Next, we simulate the radio pulse emission from the possible pulsars in these DNSs according to pulsar beam geometry and the empirical distributions of spin period and luminosity. For the DNSs detectable by TQ+LISA, the average number of DNSs detectable by the follow-up pulsar searches using the Parkes, FAST, SKA1, and SKA are 8, 10, 43, and 87, respectively. Depending on the radio telescope, the average distances of these GW-detectable pulsar binaries vary from 1 to 7 kpc. Considering the dominant radiometer noise and phase jitter noise, the timing accuracy of these GW-detectable pulsars can be as low as 70 ${\rm ns}$ while the most probable value is about 100 $\mu {\rm s}$., Comment: 15 pages, 9 figures, 3 tables. To be published in PRD
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- 2023
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7. Self-Supervised Bayesian Visual Imitation Learning Applied to Robotic Pouring.
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Dan-dan Zhang, Yu Zheng 0001, Wen Fan, Nathan F. Lepora, and Zhengyou Zhang
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- 2024
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8. Exploration on OCT biomarker candidate related to macular edema caused by diabetic retinopathy and retinal vein occlusion in SD-OCT images
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Yuhui Tao, Lexin Ge, Na Su, Mingchao Li, Wen Fan, Lin Jiang, Songtao Yuan, and Qiang Chen
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Medicine ,Science - Abstract
Abstract To improve the understanding of potential pathological mechanisms of macular edema (ME), we try to discover biomarker candidates related to ME caused by diabetic retinopathy (DR) and retinal vein occlusion (RVO) in spectral-domain optical coherence tomography images by means of deep learning (DL). 32 eyes of 26 subjects with non-proliferative DR (NPDR), 77 eyes of 61 subjects with proliferative DR (PDR), 120 eyes of 116 subjects with branch RVO (BRVO), and 17 eyes of 15 subjects with central RVO (CRVO) were collected. A DL model was implemented to guide biomarker candidate discovery. The disorganization of the retinal outer layers (DROL), i.e., the gray value of the retinal tissues between the external limiting membrane (ELM) and retinal pigment epithelium (RPE), the disrupted and obscured rate of the ELM, ellipsoid zone (EZ), and RPE, was measured. In addition, the occurrence, number, volume, and projected area of hyperreflective foci (HRF) were recorded. ELM, EZ, and RPE are more likely to be obscured in RVO group and HRFs are observed more frequently in DR group (all P ≤ 0.001). In conclusion, the features of DROL and HRF can be possible biomarkers related to ME caused by DR and RVO in OCT modality.
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- 2024
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9. Short-term culture for rapid identification by mass spectrometry and automated antimicrobial susceptibility testing from positive bottles
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Peng-Peng Tian, Shan-Shan Su, Li-Sha Zhu, Tian Wang, Hui Yang, Meng-Yao Du, Cai-Zhi Ding, Li Wang, Wen Fan, and Hua-Wei Yi
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Bloodstream infection ,Short-term culture ,Turn-around time ,Rapid identification ,Antimicrobial susceptibility testing ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Early and appropriate antibiotic treatment improves the clinical outcome of patients with sepsis. There is an urgent need for rapid identification (ID) and antimicrobial susceptibility testing (AST) of bacteria that cause bloodstream infection (BSI). Rapid ID and AST can be achieved by short-term incubation on solid medium of positive blood cultures using MALDI-TOF mass spectrometry (MS) and the BD M50 system. The purpose of this study is to evaluate the performance of rapid method compared to traditional method. Methods A total of 124 mono-microbial samples were collected. Positive blood culture samples were short-term incubated on blood agar plates and chocolate agar plates for 5 ∼ 7 h, and the rapid ID and AST were achieved through Zybio EXS2000 MS and BD M50 System, respectively. Results Compared with the traditional 24 h culture for ID, this rapid method can shorten the cultivation time to 5 ∼ 7 h. Accurate organism ID was achieved in 90.6% of Gram-positive bacteria (GP), 98.5% of Gram-negative bacteria (GN), and 100% of fungi. The AST resulted in the 98.5% essential agreement (EA) and 97.1% category agreements (CA) in NMIC-413, 99.4% EA and 98.9% CA in PMIC-92, 100% both EA and CA in SMIC-2. Besides, this method can be used for 67.2% (264/393) of culture bottles during routine work. The mean turn-around time (TAT) for obtaining final results by conventional method is approximately 72.6 ± 10.5 h, which is nearly 24 h longer than the rapid method. Conclusions The newly described method is expected to provide faster and reliable ID and AST results, making it an important tool for rapid management of blood cultures (BCs). In addition, this rapid method can be used to process most positive blood cultures, enabling patients to receive rapid and effective treatment.
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- 2024
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10. Role of umbilical cord mesenchymal stromal cells in skin rejuvenation
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Le Chang, Wei-Wen Fan, He-Ling Yuan, Xin Liu, Qiang Wang, Guang-Ping Ruan, Xing-Hua Pan, and Xiang-Qing Zhu
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Medicine - Abstract
Abstract Aging is the main cause of many degenerative diseases. The skin is the largest and the most intuitive organ that reflects the aging of the body. Under the interaction of endogenous and exogenous factors, there are cumulative changes in the structure, function, and appearance of the skin, which are characterized by decreased synthesis of collagen and elastin, increased wrinkles, relaxation, pigmentation, and other aging characteristics. skin aging is inevitable, but it can be delayed. The successful isolation of mesenchymal stromal cells (MSC) in 1991 has greatly promoted the progress of cell therapy in human diseases. The International Society for Cellular Therapy (ISCT) points out that the MSC is a kind of pluripotent progenitor cells that have self-renewal ability (limited) in vitro and the potential for mesenchymal cell differentiation. This review mainly introduces the role of perinatal umbilical cord-derived MSC(UC-MSC) in the field of skin rejuvenation. An in-depth and systematic understanding of the mechanism of UC-MSCs against skin aging is of great significance for the early realization of the clinical transformation of UC-MSCs. This paper summarized the characteristics of skin aging and summarized the mechanism of UC-MSCs in skin rejuvenation reported in recent years. In order to provide a reference for further research of UC-MSCs to delay skin aging.
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- 2024
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11. CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations
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Xiao-Wen Fan, Zi-Fan Gao, Dong-Dong Ling, De-Hui Wang, Ying Cui, Hui-Qun Du, Chun-Lin Li, and Xing Zhou
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Cas9 nickase ,CRISPR-Cas12a ,Polymerase ,Single base mutations ,Medicine (General) ,R5-920 ,Military Science - Published
- 2024
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12. Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
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Kai-Wei Jia, Ren-Qi Yao, Yi-Wen Fan, Ding-Ji Zhang, Ye Zhou, Min-Jun Wang, Li-Yuan Zhang, Yue Dong, Zhi-Xuan Li, Su-Yuan Wang, Mu Wang, Yun-Hui Li, Lu-Xin Zhang, Ting Lei, Liang-Chen Gui, Shan Lu, Ying-Yun Yang, Si-Xian Wang, Yi-Zhi Yu, Yong-Ming Yao, and Jin Hou
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Ischemia/reperfusion (I/R) ,DExH-box helicase 58 (DHX58) ,Glutathione peroxidase 4 (GPX4) ,m6A modification ,YT521-B homology domain containing 2 (YTHDC2) ,Medicine (General) ,R5-920 ,Military Science - Abstract
Abstract Background Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role in liver I/R injury, however, it remains unclear whether this process is controlled or regulated by members of the DEAD/DExH-box helicase (DDX/DHX) family. Methods The expression of DDX/DHX family members during liver I/R injury was screened using transcriptome analysis. Hepatocyte-specific Dhx58 knockout mice were constructed, and a partial liver I/R operation was performed. Single-cell RNA sequencing (scRNA-seq) in the liver post I/R suggested enhanced ferroptosis by Dhx58 hep−/− . The mRNAs and proteins associated with DExH-box helicase 58 (DHX58) were screened using RNA immunoprecipitation-sequencing (RIP-seq) and IP-mass spectrometry (IP-MS). Results Excessive production of reactive oxygen species (ROS) decreased the expression of the IFN-stimulated gene Dhx58 in hepatocytes and promoted hepatic ferroptosis, while treatment using IFN-α increased DHX58 expression and prevented ferroptosis during liver I/R injury. Mechanistically, DHX58 with RNA-binding activity constitutively associates with the mRNA of glutathione peroxidase 4 (GPX4), a central ferroptosis suppressor, and recruits the m6A reader YT521-B homology domain containing 2 (YTHDC2) to promote the translation of Gpx4 mRNA in an m6A-dependent manner, thus enhancing GPX4 protein levels and preventing hepatic ferroptosis. Conclusions This study provides mechanistic evidence that IFN-α stimulates DHX58 to promote the translation of m6A-modified Gpx4 mRNA, suggesting the potential clinical application of IFN-α in the prevention of hepatic ferroptosis during liver I/R injury.
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- 2024
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13. Coxsackievirus A24 causing acute conjunctivitis in a 2023 outbreak in Vietnam
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Huy Tran, Thao Ha, Linh Hoang, Yen Tran, Kevin Ruder, Lina Zhong, Cindi Chen, YuHeng Liu, Danny Yu, Thomas Abraham, Armin Hinterwirth, Michael Deiner, Travis C. Porco, Thomas M. Lietman, Thuy Doan, Gerami D. Seitzman, Lalitha Prajna, N. Venkatesh Prajna, Ramesh Gunasekaran, Sankalp Singh Sharma, Vishnu Teja, Meenu Chaudhary, Sanjeeta Sitaula, Ali Sié, Boubacar Coulibaly, Mamadou Bountogo, Thanapong Somkijrungroj, Vannarut Satitpitakul, Linh Hoàng Mai, Thảo Hạ Xuân, Cristhian A. Urzua, Fabian Vega, Felipe Salgado, Loreto Cuitino, Fernando Pérez Pérez, Jaime Macías Martínez, Van Charles Lansingh, Sukhumal Thanapaisal, Wipada Laovirojjanakul, George McKie, Program Officer, Kenia Chavez, Travis Redd, Winston Chamberlain, Angel Cheng, Vivien Tham, Wiwan Sansanayudh, Abba Kaka Hajia Yakoura, Abdou Amza, Abdoul Salam Youssoufou Souley, Adam Nouhou Diori, Beido Nassirou, Boubacar Kadri, Boubacar Mariama, Cissé Mamadou Ibrahim, Lamyne Aboubacar Roufaye, Ramatou Boulhassane, Saley Ali, Zakou Abdou, Lee Goren, Irit Bahar, Ruti Sella, Clare Kelliher, Laura Green, Hon Shing Ong, Jod Mehta, Yu-Chi Liu, Benjamin A. Pinsky, De-Kuang Hwang, Nai-Wen Fan, Hong Sheng Chiong, Javier Lacorzana, Maria Cabrera-Aguas, Stephanie Watson, Edmund Tsui, Nina M. Cherian, Rachel Feit-Leichman, Reginald E. Hughes, Jr, Tania Onclinx, Joseph K Privratsky, Carol Yu, Esmeralda McClean, Iliana Molina, David Liu, Elodie Lebas, Emily Colby, Gerami Seitzman, Thomas Lietman, Thuy Doan, Principal Investigator, Travis Porco, Stephen McLeod, Kuniyoshi Kanai, Meredith Whiteside, Steven Yeh, Tolulope Fashina, James Chodosh, Bridgit Tarkap, Jambi N. Garap, Magdalene Mangot, Edwin Amel, Fasihah Taleo, Johnson Kasso, Kalbule Willie, Madopule Nanu, Prudence Rymill, and Anthony W. Solomon
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Coxsackievirus ,Epidemic ,Conjunctivitis ,Keratoconjunctivitis (EKC) ,Vietnam ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: To determine the associated pathogen during the 2023 conjunctivitis outbreak in Vietnam Methods: RNA-sequencing was used to identify pathogens before and during the outbreak. Results: 24 patients with infectious conjunctivitis between March and October 2023 from Hai Yen Vision Institute in Vietnam were swabbed. Coxsackievirus A24v was the most common pathogen identified. Phylogenetic analysis of these strains demonstrates similarities to the Coxsackievirus identified in the 2022 India outbreak. Human adenovirus D was also circulating. Ocular findings of tearing, purulence, and itching were common in this outbreak. Conclusions: Multiple viruses can co-circulate during conjunctivitis outbreaks. Hemorrhagic conjunctivitis, commonly associated with coxsackievirus conjunctivitis, was not a common clinical sign in this outbreak. Repeat genetic surveillance, with the notable inclusion of RNA virus detection strategies, is important for outbreak detection.
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- 2024
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14. Spatial distribution characteristics and influence factor analysis of landslides —case study of the Hanwang area in Qinba Mountains
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Jikai Zhang, Yanbo Cao, Wen Fan, Wenbo Zheng, Zequan Wang, Chengcheng He, and Hongquan Teng
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Landslide ,Spatial distribution ,Influence factor ,Landslide density ,Deformation mechanism ,DEM ,Geophysics. Cosmic physics ,QC801-809 ,Dynamic and structural geology ,QE500-639.5 - Abstract
The geological hazards of landslides in Hanwang Town, Ziyang County, Ankang City, Shaanxi Province, have emerged. Yet, the current understanding of the spatial distribution characteristics and influencing factors of landslides in this area remains unclear. Combining the results of remote sensing interpretation and field investigation, seven influencing factors, namely, elevation, slope direction, slope gradient, distance from rivers, distance from faults, engineering geologic lithology, and distance from roads, are selected for the study. The distribution characteristics of landslides in each influencing factor and the influence of the resolution of the Digital Elevation Model (DEM) on the results are statistically and analytically analyzed. Furthermore, two high-risk landslides within the study area were subjected to comprehensive analysis, integrating the findings from drilling and other field investigations in order to examine their deformation mechanisms. Based on this analysis, the following conclusions were derived: (1) 34 landslides in the study area, mainly small earth landslides, with a distribution density of 0.42/km2, threatening 414 people and property of about 55.87 million Yuan. (2)The landslides in the study area easily occur in the
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- 2024
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15. One-Shot Domain-Adaptive Imitation Learning via Progressive Learning Applied to Robotic Pouring.
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Dandan Zhang, Wen Fan, John Lloyd, Chenguang Yang 0001, and Nathan F. Lepora
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- 2024
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16. Convex Hulls of Dragon Curves
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Wen, Fan
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Mathematics - Metric Geometry - Abstract
Dragon curves, are a family of self-similar sets in the plane. We prove that every dragon curve has a polygonal convex hull. Moreover, the vertices of the convex hull of the Dragon curves are given in some case.
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- 2022
17. Construction and application of highly efficient waste cooking oil degrading bacteria consortium in oily wastewater
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Zhao, Zhuo-qun, Yang, Jian, Chen, Heng-yuan, Wang, Wen-fan, Lian, Xiao-jian, Xie, Xiao-jie, Wang, Min, Yu, Ke-fei, and Zheng, Hua-bao
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- 2023
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18. Bifidobacterium lactis Probio‐M8 prevents nonalcoholic fatty liver disease in high‐fat diet‐fed rats: The potential role in modulating gut microbiota
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Wen Fan, Kairui Tang, Yuanjun Deng, Chuiyang Zheng, Maoxing Pan, Dajin Pi, Zheng Liang, Jianwei Zhen, Qinhe Yang, and Yupei Zhang
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Bifidobacterium lactis Probio‐M8 ,gut microbiota ,nonalcoholic fatty liver disease ,probiotics ,Food processing and manufacture ,TP368-456 - Abstract
Abstract Nonalcoholic fatty liver disease (NAFLD) is a major global health problem with few therapeutic options available so far. Accumulating evidence suggests that probiotics have beneficial effects on NAFLD by modulating gut microbiota. Bifidobacterium lactis Probio‐M8 (M8) is a new probiotic strain isolated from human breast milk. The aim of this study was to investigate whether M8 could protect against NAFLD in rats fed a high‐fat diet by modulating gut microbiota. In this study, rats were randomly distributed into four groups: normal diet (ND) group, normal diet plus M8 (ND+M8) group, high‐fat diet (HFD) group, and high‐fat diet plus M8 (HFD+M8) group. Ten weeks later, hepatic morphological changes and biochemical indicators were measured. 16S rDNA sequencing was applied to analyze the gut microbiota alterations. Our results showed that M8 administration effectively improved hepatic steatosis and liver damage in high‐fat diet‐fed rats. 16S rDNA analysis of gut microbiota indicated that M8 could modulate the gut microbiota composition, especially increasing Bifidobacterium and decreasing Bilophila, Lachnoclostridium, GCA‐900066225, and Phascolarctobacterium in high‐fat diet‐fed rats. In conclusion, our findings demonstrated that M8 could protect against NAFLD in rats fed a high‐fat diet, which may be attributed to the modulation of gut microbiota.
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- 2024
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19. Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic scar through remodeling the pathological microenvironment
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Zhuo-Ran Yang, Huinan Suo, Jing-Wen Fan, Niannian Lv, Kehan Du, Teng Ma, Huimin Qin, Yan Li, Liu Yang, Nuoya Zhou, Hao Jiang, Juan Tao, and Jintao Zhu
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Science - Abstract
Abstract Hypertrophic scar (HS) considerably affects the appearance and causes tissue dysfunction in patients. The low bioavailability of 5-fluorouracil poses a challenge for HS treatment. Here we show a separating microneedle (MN) consisting of photo-crosslinked GelMA and 5-FuA-Pep-MA prodrug in response to high reactive oxygen species (ROS) levels and overexpression of matrix metalloproteinases (MMPs) in the HS pathological microenvironment. In vivo experiments in female mice demonstrate that the retention of MN tips in the tissue provides a slowly sustained drug release manner. Importantly, drug-loaded MNs could remodel the pathological microenvironment of female rabbit ear HS tissues by ROS scavenging and MMPs consumption. Bulk and single cell RNA sequencing analyses confirm that drug-loaded MNs could reverse skin fibrosis through down-regulation of BCL-2-associated death promoter (BAD), insulin-like growth factor 1 receptor (IGF1R) pathways, simultaneously regulate inflammatory response and keratinocyte differentiation via up-regulation of toll-like receptors (TOLL), interleukin-1 receptor (IL1R) and keratinocyte pathways, and promote the interactions between fibroblasts and keratinocytes via ligand-receptor pair of proteoglycans 2 (HSPG2)-dystroglycan 1(DAG1). This study reveals the potential therapeutic mechanism of drug-loaded MNs in HS treatment and presents a broad prospect for clinical application.
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- 2024
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20. Application and challenges of stem cells in cardiovascular aging
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He-Ling Yuan, Le Chang, Wei-Wen Fan, Xin Liu, Qiang Li, Chuan Tian, Jing Zhao, Zi-An Li, Xing-Hua Pan, and Xiang-Qing Zhu
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Stem cells ,Cardiovascular aging ,Exocrine body ,Treatment ,Cardiovascular disease ,Medicine (General) ,R5-920 ,Cytology ,QH573-671 - Abstract
With the rapid development of society and the economy, population aging has become a common challenge faced by many countries in the world today. Structural and functional changes in the cardiovascular system can occur with age, increasing the incidence and severity of cardiovascular diseases in older adults. Due to the limited regenerative capacity of myocardial cells, myocardial infarction and its resulting heart failure and congenital heart disease have become the number one killer of human health. At present, the treatment of cardiovascular diseases includes drug therapy and nondrug therapy. Nondrug therapy mainly includes minimally invasive interventional therapy, surgical diagnosis and treatment, and cell therapy. Long-term drug treatment may cause headache due to vasodilation, lower blood pressure, digestive system dysfunction and other side effects. Surgical treatment is traumatic, difficult to treat, and expensive. In recent years, stem cell therapy has exhibited broad application prospects in basic and clinical research on cardiovascular disease because of its plasticity, self-renewal and multidirectional differentiation potential. Therefore, this paper looks at stem cell therapy for diseases, reviews recent advances in the mechanism and clinical transformation of cardiovascular aging and related diseases in China, and briefly discusses the development trend and future prospects of cardiovascular aging research.
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- 2024
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21. Frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students
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Jie Cai, Wen-Wen Fan, Yun-Hui Zhong, Cai-Lan Wen, Xiao-Dan Wei, Wan-Chen Wei, Wan-Yan Xiang, and Jin-Mao Chen
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optometry clinic ,non-strabismic binocular vision dysfunction ,college students ,convergence insufficiency ,Ophthalmology ,RE1-994 - Abstract
AIM: To investigate the frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students. METHODS: Totally 158 student volunteers underwent routine vision examination in the optometry clinic of Guangxi Medical University. Their data were used to identify the different types of accommodation and non-strabismic binocular vision dysfunction and to determine their frequency. Correlation analysis and logistic regression were used to examine the factors associated with these abnormalities. RESULTS: The results showed that 36.71% of the subjects had accommodation and non-strabismic binocular vision issues, with 8.86% being attributed to accommodation dysfunction and 27.85% to binocular abnormalities. Convergence insufficiency (CI) was the most common abnormality, accounting for 13.29%. Those with these abnormalities experienced higher levels of eyestrain (χ2=69.518, P
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- 2024
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22. Mechanisms of Bushen Tiaoxue Granules against controlled ovarian hyperstimulation-induced abnormal morphology of endometrium based on network pharmacology
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Jia-Cheng Zhang, Hao-Lin Zhang, Xi-Yan Xin, Yu-Tian Zhu, Xin Mao, Hang-Qi Hu, Yu-Xin Jin, Rui-Wen Fan, Xiao-Hui Zhang, Yang Ye, and Dong Li
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Bushen Tiaoxue Granules ,Controlled ovarian hyperstimulation ,Endometrium ,Experimental validation ,Morphology ,Network pharmacology ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Bushen Tiaoxue Granules (BTG) is an empirical Chinese herbal formula that has been used for the treatment of subfertility. The protective effect of BTG on controlled ovarian hyperstimulation (COH)-induced impaired endometrial receptivity has been reported in our previous study. This study aims to explore the mechanisms of BTG on ameliorating abnormal morphology of endometrium based on network pharmacology. Active compounds of BTG were identified via the traditional Chinese medicine systems pharmacology and UPLC-MS technology. The SwissTargetPrediction platform and HERB database were used to screen out the putative targets of BTG. Potential targets of endometrial dysfunction caused by COH were obtained from three GEO databases. Through the STRING database, the protein–protein interaction was carried out according to the cross-common targets of diseases and drugs. GO terms and KEGG pathways enrichment analyses were conducted via the Metascape database. AutoDock Vina was used for docking validation of the affinity between active compounds and potential targets. Finally, in vivo experiments were used to verify the potential mechanisms derived from network pharmacology study. A total of 141 effective ingredients were obtained from TCMSP and nine of which were verified in UPLC-MS. Six genes were selected through the intersection of 534 disease related genes and 165 drug potential targets. Enrichment analyses showed that BTG might reverse endometrial dysfunction by regulating adherens junction and arachidonic acid metabolism. Hematoxylin–eosin staining revealed that BTG ameliorated the loose and edematous status of endometrial epithelium caused by COH. The protein expression of FOXO1A, β-Catenin and COX-2 was decreased in the COH group, and was up-regulated by BTG. BTG significantly alleviates the edema of endometrial epithelium caused by COH. The mechanisms may be related to adheren junctions and activation of arachidonic acid metabolism. The potential active compounds quercetin, taxifolin, kaempferol, eriodictyol, and isorhamnetin identified from the BTG exhibit marginal cytotoxicity. Both high and low concentrations of kaempferol, eriodictyol, and taxifolin are capable of effectively ameliorating impaired hESC cellular activity.
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- 2024
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23. Synthesis of Pd/(MnO2@PANI) Catalyst and Its Study on the Reduction of Cr(VI)
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Li, Dianzhao, Cao, Yuhong, Yu, Dailiang, and Wen, Fan
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- 2024
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24. Enhancement of Ce and Cr Codopant Solubility and Chemical Homogeneity in TiO2 Nanoparticles through Sol Gel versus Pechini Syntheses
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Chen, Wen-Fan, Mofarah, Sajjad S., Hanaor, Dorian Amir Henry, Koshy, Pramod, Chen, Hsin-Kai, Jiang, Yue, and Sorrell, Charles Christopher
- Subjects
Condensed Matter - Materials Science - Abstract
Ce/Cr codoped TiO2 nanoparticles were synthesized using sol gel and Pechini methods with heat treatment at 400 C for 4 h. A conventional sol gel process produced well-crystallized anatase, while Pechini synthesis yielded less ordered mixed-phase anatase and rutile; this suggests that the latter method enhances Ce solubility and increases chemical homogeneity but destabilizes the TiO2 lattice. Greater structural disruption from the decomposition of the Pechini precursor formed more open agglomerated morphologies, while the lower levels of structural disruption from pyrolysis of the dried sol gel precursor resulted in denser agglomerates of lower surface areas. Codoping and associated destabilization of the lattice reduced the binding energies in both powders. Cr4+ formation in sol gel powders and Cr6+ formation in Pechini powders suggest that these valence changes derive from synergistic electron exchange from intervalence and/or multivalence charge transfer. Since Ce is too large to allow either substitutional or interstitial solid solubility, the concept of integrated solubility is introduced, in which the Ti site and an adjacent interstice are occupied by the large Ce ion. The photocatalytic performance data show that codoping was detrimental owing to the effects of reduced crystallinity from lattice destabilization and surface area. Two regimes of mechanistic behavior are seen, which are attributed to the unsaturated solid solutions at lower codopant levels and supersaturated solid solutions at higher levels. The present work demonstrates that the Pechini method offers a processing technique that is superior to sol gel because the former facilitates solid solubility and consequent chemical homogeneity.
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- 2022
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25. Note on quasisymmetric rigidity of carpets
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Sheng, Yahui, Wei, Chun, and Wen, Fan
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- 2024
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26. Characterization of thyroid metastasis from clear cell renal cell carcinoma on ultrasonography: a report of three cases and literature review
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Hai-Yan Jia, Juan Chen, Zi-Xin Zhai, Wen-Wen Fan, Si-Jie Yuan, Qiong Liu, Xiao-Hui Yan, Qian-Qian Shen, and Li-Ping Liu
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thyroid ,clear cell renal cell carcinoma ,metastasis ,ultrasonography ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Introduction: Thyroid metastasis from clear cell renal cell carcinoma (ccRCC) is relatively rare, so ultrasound doctors lack experience with the disease, which can easily lead to misdiagnosis. We describe three cases of thyroid metastasis from ccRCC detected 12, 8, and 7 years after nephrectomy. Case presentation: The first patient, a 78-year-old woman, was admitted to our ins titution for hoarseness and progressive dyspnea. Ultrasonography revealed bilateral thyroid nodules and abnormal cervical lymph nodes. Fine-needle aspiration biopsy (FNAB) and core needle biopsy (CNB) of the thyroid was nondiagnostic. The other two patients, a 54-year-old man and a 65-year-old man, were admitted to our institution for a goiter pressing on the trachea. In each case, ultrasonography revealed a partially cystic nodule of the left lobe of the thyroid gland. Histological examination of three patients after thyroidectomy showed thyroid metastasis from ccRCC. Discussion/Conclusion: For patients with a history of ccRCC, long-term follow-up and routine thyroid ultrasonography should be performed. If a new thyroid nodule is found during the examination, metastases should be highly suspected. FNAB should be performed, even if benign ultrasound features seem to be in evidence. If the diagnosis of FNAB is incorrect and inconclusive, CNB should be performed.
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- 2023
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27. Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway
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Wen Fan, Chong Liu, Dacai Chen, Chenjie Xu, Xiuting Qi, Ailin Zhang, Xuexian Zhu, Yujie Liu, Lei Wang, Lanxiang Hao, Wen-Tao Liu, and Liang Hu
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Ozone ,AMPK ,Gas 6 ,MerTK ,SOCS3 ,MMP9 ,Medicine - Abstract
Abstract Background Gout pain seriously affects the quality of patients' life. There is still no effective treatment. The inflammatory response is the main mechanism of gout. Here, we found that ozone can reduce the inflammatory reaction in the joints of gouty mice and relieve gout pain, and we further explore its protective mechanism. Methods MSU was used to establish the gouty mice model. Nociception was assessed by Von Frey hairs. Cell signaling assays were performed by western blotting and immunohistochemistry. The mouse leukemia cells of monocyte macrophage line RAW264.7 were cultured to investigate the effects of ozone administration on macrophage. Results Ozone reduced inflammation, relieved gout pain and improved the paw mean intensity and duty cycle of the gouty mice. Ozone increased the phosphorylation of AMP-activated protein kinase (AMPK), induced suppressor of cytokine signaling 3 (SOCS3) expression and inhibited metallopeptidase 9 (MMP9) expression. In vivo, ozone activated AMPK to induce Gas6 release, and upregulated MerTK/SOCS3 signaling pathway to reduce inflammation in mouse macrophage line RAW264.7. Inhibitors of AMPK and MerTK, respectively abolished the analgesic and anti-inflammatory effects of ozone in vivo and in vitro. Gas6 knockout cancelled the protectively effects of ozone on gout pain and the paw mean intensity and duty cycle of gouty mice. Additionally, the level of Gas6 and protein S in plasma of patients with hyperuricemia was significantly higher than that of healthy contrast group. Conclusion Ozone reduces inflammation and alleviates gout pain by activating AMPK to up-regulate Gas6/MerTK/SOCS3 signaling pathway.
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- 2023
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28. On Norms of Iterations of {0,1}-Matrices
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Wei, Chun and Wen, Fan
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Mathematics - Spectral Theory ,Mathematics - Functional Analysis - Abstract
Let M be a b*b nonzero {0,1}-matrix. Let \rho(M) be its spectral radius and let |M^n| be the norm of its n-th iteration. In the case \rho(M)>1, we see from the spectral radius formula that {|M^n|}_{n=1}^\infty tends to \infty exponentially as n to \infty. In the case \rho(M)=1, {|M^n|}_{n=1}^\infty can be bounded or tend to \infty depending on M. The fine behavior of this sequence is completely characterized in the present paper.
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- 2021
29. Design and Evaluation of a Rapid Monolithic Manufacturing Technique for a Novel Vision-Based Tactile Sensor: C-Sight
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Wen Fan, Haoran Li, Yifan Xing, and Dandan Zhang
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vision-based tactile sensor ,monolithic 3D printing ,contact reconstruction ,Chemical technology ,TP1-1185 - Abstract
Tactile sensing has become indispensable for contact-rich dynamic robotic manipulation tasks. It provides robots with a better understanding of the physical environment, which is a vital supplement to robotic vision perception. Compared with other existing tactile sensors, vision-based tactile sensors (VBTSs) stand out for augmenting the tactile perception capabilities of robotic systems, owing to superior spatial resolution and cost-effectiveness. Despite their advantages, VBTS production faces challenges due to the lack of standardised manufacturing techniques and heavy reliance on manual labour. This limitation impedes scalability and widespread adoption. This paper introduces a rapid monolithic manufacturing technique and evaluates its performance quantitatively. We further develop and assess C-Sight, a novel VBTS sensor manufactured using this technique, focusing on its tactile reconstruction capabilities. Experimental results demonstrate that the monolithic manufacturing technique enhances VBTS production efficiency significantly. Also, the fabricated C-Sight sensor exhibits its reliable tactile perception and reconstruction capabilities, proofing the validity and feasibility of the monolithic manufacturing method.
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- 2024
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30. Leverage Effective Deep Learning Searching Method for Forensic Age Estimation
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Zhi-Yong Zhang, Chun-Xia Yan, Qiao-Mei Min, Yu-Xiang Zhang, Wen-Fan Jing, Wen-Xuan Hou, and Ke-Yang Pan
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age estimation ,deep neural network (DNN) ,orthopantomograms (OPGs) ,Neural Architecture Search (NAS) ,Technology ,Biology (General) ,QH301-705.5 - Abstract
Dental age estimation is extensively employed in forensic medicine practice. However, the accuracy of conventional methods fails to satisfy the need for precision, particularly when estimating the age of adults. Herein, we propose an approach for age estimation utilizing orthopantomograms (OPGs). We propose a new dental dataset comprising OPGs of 27,957 individuals (16,383 females and 11,574 males), covering an age range from newborn to 93 years. The age annotations were meticulously verified using ID card details. Considering the distinct nature of dental data, we analyzed various neural network components to accurately estimate age, such as optimal network depth, convolution kernel size, multi-branch architecture, and early layer feature reuse. Building upon the exploration of distinctive characteristics, we further employed the widely recognized method to identify models for dental age prediction. Consequently, we discovered two sets of models: one exhibiting superior performance, and the other being lightweight. The proposed approaches, namely AGENet and AGE-SPOS, demonstrated remarkable superiority and effectiveness in our experimental results. The proposed models, AGENet and AGE-SPOS, showed exceptional effectiveness in our experiments. AGENet outperformed other CNN models significantly by achieving outstanding results. Compared to Inception-v4, with the mean absolute error (MAE) of 1.70 and 20.46 B FLOPs, our AGENet reduced the FLOPs by 2.7×. The lightweight model, AGE-SPOS, achieved an MAE of 1.80 years with only 0.95 B FLOPs, surpassing MobileNetV2 by 0.18 years while utilizing fewer computational operations. In summary, we employed an effective DNN searching method for forensic age estimation, and our methodology and findings hold significant implications for age estimation with oral imaging.
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- 2024
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31. Study on the biodegradation characteristics and mechanism of tetracycline by Serratia entomophila TC-1
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Xie, Xiao-jie, Zhang, Tao, Yang, Jian, Wang, Wen-fan, Zhao, Zhuo-qun, Barceló, Damià, and Zheng, Hua-bao
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- 2024
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32. Automated Quantification of Hyperreflective Foci in SD-OCT With Diabetic Retinopathy.
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Idowu Paul Okuwobi, Zexuan Ji, Wen Fan, Songtao Yuan, Loza Bekalo, and Qiang Chen 0004
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- 2024
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33. A UAV-Enabled Time-Sensitive Data Collection Scheme for Grassland Monitoring Edge Networks.
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Dongbin Jiao, Zihao Wang, Wen Fan, Weibo Yang, Peng Yang 0008, Zhanhuan Shang, and Shi Yan
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- 2024
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34. MagicTac: A Novel High-Resolution 3D Multi-layer Grid-Based Tactile Sensor.
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Wen Fan, Haoran Li, and Dandan Zhang
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- 2024
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35. ViTacTip: Design and Verification of a Novel Biomimetic Physical Vision-Tactile Fusion Sensor.
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Wen Fan, Haoran Li, Weiyong Si, Shan Luo 0001, Nathan F. Lepora, and Dandan Zhang
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- 2024
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36. Compressible FSI of elastic spikes for drag reduction under hypersonic flow
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Wang, Wen-Fan, Mei, Mei, Wang, Zhi-Qiao, Zhou, Zhi-Fu, and Wu, Wei-Tao
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- 2024
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37. Capacity of community health centers to treat snakebite envenoming in indigenous territories of the Brazilian Amazon
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Sachett, André, Strand, Eleanor, Serrão-Pinto, Thiago, da Silva Neto, Alexandre, Pinto Nascimento, Thais, Rodrigues Jati, Sewbert, dos Santos Rocha, Gisele, Ambrósio Andrade, Sediel, Wen, Fan Hui, Berto Pucca, Manuela, Vissoci, João, Gerardo, Charles J., Sachett, Jacqueline, Seabra de Farias, Altair, and Monteiro, Wuelton
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- 2024
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38. River dataset as a potential fluvial transportation network for healthcare access in the Amazon region
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Rocha, Thiago Augusto Hernandes, Silva, Lincoln Luís, Wen, Fan Hui, Sachett, Jacqueline, Tupetz, Anna, Staton, Catherine Ann, Monteiro, Wuelton Marcelo, Vissoci, Joao Ricardo Nickenig, and Gerardo, Charles John
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- 2023
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39. Large-scale mechanism hypothesis and research prospects of cognitive impairment in schizophrenia based on magnetic resonance imaging
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Yue-Wen Gu, Jing-Wen Fan, Shu-Wan Zhao, Xiao-Fan Liu, Hong Yin, and Long-Biao Cui
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Schizophrenia ,Cognitive impairments ,Connectome ,Magnetic resonance imaging ,Treatment ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Cognitive impairments in schizophrenia are pivotal clinical issues that need to be solved urgently. However, the mechanism remains unknown. It has been suggested that cognitive impairments in schizophrenia are associated with connectome damage, and are especially relevant to the disrupted hub nodes in the frontal and parietal lobes. Activating the dorsolateral prefrontal cortex (DLPFC) via repetitive transcranial magnetic stimulation (rTMS) could result in improved cognition. Based on several previous magnetic resonance imaging (MRI) studies on schizophrenia, we found that the first-episode patients showed connectome damage, as well as abnormal activation and connectivity of the DLPFC and inferior parietal lobule (IPL). Accordingly, we proposed that DLPFC-IPL pathway destruction might mediate connectome damage of cognitive impairments in schizophrenia. In the meantime, with the help of multimodal MRI and noninvasive neuromodulation tool, we may not only validate the hypothesis, but also find IPL as the potential intervention target for cognitive impairments in schizophrenia.
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- 2024
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40. Simultaneous detection of human norovirus GI, GII and SARS-CoV-2 by a quantitative one-step triplex RT-qPCR
- Author
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Hua-Wei Yi, Xian-Mo Wang, Xin Tan, Cai-Zhi Ding, Chang-Li Zhang, Jia-Hao Wu, Qi Li, Chen-Qi Xin, and Wen Fan
- Subjects
norovirus ,SARS-CoV-2 ,nucleic acid detection ,RT-qPCR ,genotyping ,Microbiology ,QR1-502 - Abstract
BackgroundThere are many similarities in the clinical manifestations of human norovirus and SARS-CoV-2 infections, and nucleic acid detection is the gold standard for diagnosing both diseases. In order to expedite the identification of norovirus and SARS-CoV-2, a quantitative one-step triplex reverse transcription PCR (RT-qPCR) method was designed in this paper.MethodsA one-step triplex RT-qPCR assay was developed for simultaneous detection and differentiation of human norovirus GI (NoV-GI), GII (NoV-GII) and SARS-CoV-2 from fecal specimens.ResultsThe triplex RT-qPCR assay had high detection reproducibility (CV
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- 2024
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41. Prediction model for elevated intraocular pressure risk after silicone oil filling based on clinical features
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Wen Fan, Chaohe Zhang, Lexin Ge, Na Su, Jiaqin Chen, Siyao Song, Yasha Wang, and Songtao Yuan
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prediction model ,intraocular pressure ,ocular hypertension ,pars plana vitrectomy ,silicone oil ,biological parameter ,Medicine (General) ,R5-920 - Abstract
BackgroundTo evaluate risk factors and further develop prediction models for intraocular pressure elevation (IOP) after vitreoretinal surgery with silicone oil tamponade to support clinical management.MethodsA retrospective study analyzed 1,061 eyes of 1,061 consecutive patients that presented to the Jiangsu Province Hospital between December 2015 and December 2020, the IOP was measured from the preoperative visit and at the 1-week, 1-month, 3-month, and 6-month visits, and the final postoperative visit before silicone oil removal. Four machine learning methods were used to carried out the prediction of IOP elevation: Decision Tree, Logistic Regression, Random Forest, and Gradient-Boosted Decision Trees (GBDT) based on features including demographic and clinical characteristics, preoperative factors and surgical factors. Predictors were selected based on the p-value of the univariate analysis.ResultsElevated intraocular pressure developed in 26.01% of the eyes postoperatively. Elevated intraocular pressure primarily occurred within 1–2 weeks after surgery. Additionally, the majority of IOP values were distributed around 25–40 mmHg. GBDT utilizing features with p-values less than 0.5 from the hypothesis testing demonstrated the best predictive performance for 0.7944 in accuracy. The analysis revealed that age, sex, hypertension, diabetes, myopia, retinal detachment, lens status and biological parameters have predictive value.ConclusionAge, sex, hypertension, diabetes, myopia, retinal detachment, lens status and biological parameters have influence on postoperative intraocular pressure elevation for patients with silicone oil tamponade after pars plana vitrectomy. The prediction model showed promising accuracy for the occurrence of IOP elevation. This may have some reference significance for reducing the incidence of high intraocular pressure after pars plana vitrectomy combined with silicone oil filling.
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- 2024
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42. Topological Rigidity of good fractal necklaces
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Wen, Fan
- Subjects
Mathematics - Dynamical Systems ,Mathematics - General Topology - Abstract
We introduce and characterize extremal 2-cuts for good fractal necklaces. Using the characterization and the related topological properties of extremal 2-cuts, we prove that every good necklace has a unique necklace IFS in a certain sense. Also, we prove that two good necklaces admit only rigid homeomorphisms and thus the group of self-homeomorphisms of a good necklace is countable. In addition, a certain weaker co-Hopfian property of good necklaces is also obtained.
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- 2021
43. Fractal necklaces with no cut points
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Wen, Fan
- Subjects
Mathematics - General Topology - Abstract
The fractal necklaces in R^d (d>1) introduced in this paper are a class of connected fractal sets generated by the so-called necklace IFSs, for which a lot of basic topology questions are interesting. We give two subclasses of fractal necklaces and prove that every necklace in these two classes has no cut points. Also, we prove that every stable self-similar necklace in R^2 has no cut points, whilst an analog for self-affine necklaces is false.
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- 2021
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44. TIMS: A Tactile Internet-Based Micromanipulation System with Haptic Guidance for Surgical Training.
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Jialin Lin, Xiaoqing Guo, Wen Fan, Wei Li, Yuanyi Wang, Jiaming Liang, Jindong Liu, Weiru Liu, Lei Wei, and Dandan Zhang
- Published
- 2023
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45. Human-Like Motion Planning of Anthropomorphic Arms Based on Hierarchical Strategy.
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Yu-Quan Lin, Xuchong Zhang, Wen-Fan Li, and Xiao-Hui Ma
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- 2023
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46. Vicious Cycles in Distributed Software Systems.
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Shangshu Qian, Wen Fan, Lin Tan 0001, and Yongle Zhang
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- 2023
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47. Evaluating and Alleviating Multidimensional Poverty among Older People in Rural China Based on Big Data.
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Yan Zhang, Wen Fan, and Siyu Pan
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- 2023
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48. Tac-VGNN: A Voronoi Graph Neural Network for Pose-Based Tactile Servoing.
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Wen Fan, Max Yang, Yifan Xing, Nathan F. Lepora, and Dandan Zhang
- Published
- 2023
- Full Text
- View/download PDF
49. Characteristics of loess seismic subsidence and corresponding micro-zonation for the Fuping Country, Shaanxi
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Sen REN, Longsheng DENG, Wen FAN, Liangxin XU, and Shaopeng LIU
- Subjects
dynamic triaxial test ,seismic subsidence of loess ,seismic subsidence evaluation ,micro zonation of seismic subsidence in fuping county ,Geology ,QE1-996.5 - Abstract
Typical loess generally shows the property of strong seismic subsidence due to its special microstructure characteristics. Fuping County which is located in the connection zone of Weihe Basin and Ordos Platform possesses complex seismic tectonic settings, high seismic fortification intensity, and widely distributed loess strata. Consequently, the risk of loess seismic subsidence is relatively high for the loess site of the region. In this paper, the regions of Fuping City and Fuping-Yanliang new area were chosen as the study area. The technical methods, such as data collection, field investigation, laboratory test, and theoretical analysis, were adopted to determine the seismic geological conditions of the region. The ground motion parameters with different transcendental probability levels were obtained by adopting the probability analysis method of seismic risk. The seismic subsidence properties of loess from various landforms and strata were studied based on a large number of dynamic triaxial tests. On this basis, Evaluate the seismic subsidence of loess sites under strong earthquakes in Fuping County. Under the condition of a probability of exceeding 10% in 50 years, mild and moderate seismic subsidence areas in the study area are distributed in the Fuyuan and Weihe secondary terraces. Under the condition of a probability of exceeding 2% in 50 years, the mild and moderate loess seismic subsidence areas in the study area are mainly distributed in the third to fourth level terraces of the Shichuan River, the floating plateau, and the second level terraces of the Wei River. Severe seismic subsidence areas are mainly distributed in the second level terraces of the Weihe River, the third to fourth level terraces of the Shichuan River, and the floating plateau. Based on the seismic subsidence level, the loess seismic subsidence sub regions of the study area were given at the 10% and 2% probability of exceedance in 50 years. Attention should be paid to this part of potential earthquake geological disaster in the design of prevention and foundation.
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- 2023
- Full Text
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50. Differential expression of diacylglycerol kinase ζ is involved in inferior parietal lobule-related dysfunction in schizophrenia with cognitive impairments
- Author
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Xiao-Fan Liu, Shu-Wan Zhao, Jin-Jin Cui, Yue-Wen Gu, Jing-Wen Fan, Yu-Fei Fu, Ya-Hong Zhang, Hong Yin, Kun Chen, and Long-Biao Cui
- Subjects
Inferior parietal lobule ,Schizophrenia ,Cognitive function ,Transcriptome ,Psychiatry ,RC435-571 - Abstract
Abstract Background Cognitive impairment is the main factor in the poor prognosis of schizophrenia, but its mechanism remains unclear. The inferior parietal lobule (IPL) is related to various clinical symptoms and cognitive impairment in schizophrenia. We aimed to explore the relationship between IPL-related functions and cognitive impairment in schizophrenia. Methods 136 schizophrenia patients and 146 demographically matched healthy controls were enrolled for a cross-sectional study. High-spatial-resolution structural and resting-state functional images were acquired to demonstrate the alternations of brain structure and function. At the same time, the digit span and digit symbol coding tasks of the Chinese Wechsler Adult Intelligence Test Revised (WAIS-RC) were utilized in assessing the subjects’ cognitive function. Patients were divided into cognitive impairment and normal cognitive groups according to their cognitive score and then compared whether there were differences between the three groups in fractional amplitude of low-frequency fluctuation (fALFF). In addition, we did a correlation analysis between cognitive function and the fALFF for the left IPL of patients and healthy controls. Based on the Allen Human Brain Atlas, we obtained genes expressed in the left IPL, which were then intersected with the transcriptome-wide association study results and differentially expressed genes in schizophrenia. Results Grouping of patients by the backward digit span task and the digit symbol coding task showed differences in fALFF values between healthy controls and cognitive impairment patients (P 0.017). In addition, we found that diacylglycerol kinase ζ (DGKζ) is differentially expressed in the left IPL and associated with schizophrenia. Conclusion Our study demonstrates that the left IPL plays a vital role in cognitive impairment in schizophrenia. DGKζ may act as an essential regulator in the left IPL of schizophrenia patients with cognitive impairment.
- Published
- 2023
- Full Text
- View/download PDF
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