33 results on '"Wen-Zhou Zhang"'
Search Results
2. Statistical Characteristics of Remote Sensing Extreme Temperature Anomaly Events in the Taiwan Strait
- Author
-
Ze-Feng Jin and Wen-Zhou Zhang
- Subjects
sea surface temperature ,marine heatwave ,marine cold spell ,extreme temperature anomaly event ,Taiwan Strait ,Science - Abstract
With global warming, the global ocean is experiencing more and stronger marine heatwaves (MHWs) and less and weaker marine cold spells (MCSs). On the regional scale, the complex circulation structure means that the changes in sea surface temperature (SST) and extreme temperature anomaly events in the Taiwan Strait (TWS) exhibit unique regional characteristics. In summer (autumn), the SST in most regions of the TWS has a significant increasing trend with a regionally averaged rate of 0.22 °C (0.19 °C) per decade during the period 1982–2021. In winter and spring, the SST in the western strait shows a significant decreasing trend with a maximum decreasing rate of −0.48 °C per decade, while it shows an increasing trend in the eastern strait. The annual mean results show that the TWS is experiencing more MHWs and MCSs with time. The frequency of the MHWs in the eastern strait is increasing faster than that in the western strait. In the western region controlled by the Zhe-Min Coastal Current, the MCSs have an increasing trend while in the other areas they have a decreasing trend. The MHWs occur in most areas of the TWS in summer and autumn, but the MCSs are mainly concentrated in the west of the TWS in spring and winter. The cooling effect of summer upwelling tends to inhibit the occurrence of MHWs and enhance MCSs. The rising background SST is a dominant driver for the increasing trend of summer MHWs. By contrast, both the SST decreasing trend and internal variability contribute to the winter MCSs increasing trend in the strait.
- Published
- 2024
- Full Text
- View/download PDF
3. Tropical Cyclones Related Wind Power on Oceanic Near‐Inertial Oscillations
- Author
-
Sheng Lin, Yuntao Wang, Wen‐Zhou Zhang, Qin‐Biao Ni, and Fei Chai
- Subjects
tropical cyclones ,near‐inertial oscillations ,wind power ,drifter ,ocean currents ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract Wind power input to oceanic near‐inertial oscillations (NIOs) plays a crucial role in sustaining the global ocean conveyor belt. However, the impact of tropical cyclones (TCs) on wind power input to NIOs, despite being the most vigorous atmospheric dynamics capable of exciting NIOs, is often overlooked in global estimations due to their transient nature and a lack of observations. Utilizing hourly wind and ocean current records, we quantified the wind power on NIOs induced by TCs from 1990 to 2019. Our findings reveal that the wind power on NIOs due to TCs is estimated to be between 0.028 and 0.065 TW, which accounts for a significant proportion, that is, 8%–17%, of that over the globe. This study highlights the importance of incorporating the wind power induced by TCs when estimating the global wind power on NIOs, as its impact is non‐negligible. Our findings contribute to a better understanding of the global energy balance by improving the estimation of wind power on NIOs.
- Published
- 2023
- Full Text
- View/download PDF
4. An extraordinary chlorophyll-a enhancement event jointly induced by two sequential tropical cyclones in the Kuroshio region south of Japan
- Author
-
Hui Zheng and Wen-Zhou Zhang
- Subjects
chlorophyll-a enhancement event ,tropical cyclone ,BGC-Argo ,Kuroshio region ,eddy ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
We used Biogeochemical-Argo (BGC-Argo) float observation profiles and satellite data to investigate the physical-biogeochemical processes of a phytoplankton biomass rise in the Kuroshio region south of Japan during a period of two sequential tropical cyclones (TCs)—Hagibis and Neoguri—in October 2019. During TC Hagibis, prominent sea surface cooling and surface chlorophyll-a (Chl-a) increase occurred within a pre-existing cyclonic eddy (CE) south of Japan. Because of TC-induced mixing and upwelling, the maximum cooling happened at the depth of 57 m where water temperature dropped by 6°C. The dramatic mixing and upwelling redistributed chlorophyll-a vertically (reducing subsurface Chl-a and increasing surface Chl-a) with little augment of depth-integrated Chl-a in the upper ocean above 160 m depth. Meanwhile, the mixing and upwelling transported nutrients from the subsurface to the surface layer. In the week after Hagibis, the depth-integrated Chl-a greatly increased. Subsequently, TC Neoguri obviously enhanced the augment of phytoplankton biomass although it was weaker than Hagibis. The upwelling induced by Hagibis increased nutrients in the water below 80 m, providing a very favorable condition for the subsequent TC Neoguri to further promote the growth of phytoplankton. The intense precipitation accompanying with Neoguri brought the coastal water with rich terrestrial material to offshore ocean, increasing nutrients and decreasing salinity in the subsurface layer. These both contributed to the marked increase in Chl-a during Neoguri. Our results demonstrated that the two sequential TCs worked together with a cyclonic eddy to cause a drastic and complex Chl-a enhancement event in the Kuroshio region south of Japan.
- Published
- 2023
- Full Text
- View/download PDF
5. Mechanism of oceanic eddies in modulating the sea surface temperature response to a strong typhoon in the western North Pacific
- Author
-
Sheng Lin, Wen-Zhou Zhang, Yuntao Wang, and Fei Chai
- Subjects
oceanic response ,typhoon ,coupled atmosphere-ocean model ,cyclonic eddy ,horizontal advection ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Eddies are ubiquitous mesoscale dynamics in oceans worldwide that prominently influence the upper ocean. Specifically, the presence of preexisting eddies can modulate oceanic responses to passing typhoons, for which the underlying mechanism requires further investigation. In 2013, Typhoon Soulik traveled over 2,000 km in the western North Pacific, encountering multiple eddies, offering a suitable opportunity for investigating the impact of eddies on typhoon-induced upper ocean responses. A coupled ocean-atmosphere model was developed for this event, and the simulations were validated with multiple observations. The surface cold wake after Typhoon Soulik was successfully reproduced by the coupled model, showing a multicore structure, which was due to the preexisting mesoscale cyclonic eddies along the typhoon path. An experimental case excluding eddies was also tested in the numerical model. The comparison between the control and experimental cases revealed that sea surface cooling was enhanced by eddies via the vertical mixing and horizontal advection of eddy-related currents. In particular, vertical mixing enhanced sea surface cooling beneath the typhoon center due to the stronger vertical stratification within the preexisting cyclonic oceanic eddies. The eddy-related current with a horizontal temperature gradient contributed to advection, enhancing sea surface cooling at the cooling center and leading to a rightward-shifted pattern of enhanced sea surface cooling. This study enriches the understanding of the complex upper ocean dynamics under the combined effects of typhoons and eddies.
- Published
- 2023
- Full Text
- View/download PDF
6. Emerging role of m6A methylation modification in ovarian cancer
- Author
-
Lin-Lin Chang, Xia-Qing Xu, Xue-Ling Liu, Qian-Qian Guo, Yan-Nan Fan, Bao-Xia He, and Wen-Zhou Zhang
- Subjects
m6A modification ,Methyltransferase ,Demethylase ,RNA binding protein ,OC ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract m6A (N6-methyladenosine) methylation, a well-known modification in tumour epigenetics, dynamically and reversibly fine tunes the entire process of RNA metabolism. Aberrant levels of m6A and its regulators, which can predict the survival and outcomes of cancer patients, are involved in tumorigenesis, metastasis and resistance. Ovarian cancer (OC) ranks first among gynaecological tumours in the causes of death. At first diagnosis, patients with OC are usually at advanced stages owing to a lack of early biomarkers and effective targets. After treatment, patients with OC often develop drug resistance. This article reviews the recent experimental advances in understanding the role of m6A modification in OC, raising the possibility to treat m6A modification and its regulators as promising diagnostic markers and therapeutic targets for OC. Graphical Abstract
- Published
- 2021
- Full Text
- View/download PDF
7. AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1α and metabolic reprogramming
- Author
-
Lin-Lin Chang, Pei-Hua Lu, Wei Yang, Yan Hu, Lin Zheng, Qiong Zhao, Neng-Ming Lin, and Wen-Zhou Zhang
- Subjects
HIF-1α ,AKR1C1 ,Metabolic reprogramming ,Proliferation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Non-small cell lung cancer (NSCLC) ranks first among cancer death worldwide. Despite efficacy and safety priority, targeted therapy only benefits ∼30% patients, leading to the unchanged survival rates for whole NSCLC patients. Metabolic reprogramming occurs to offer energy and intermediates for fuelling cancer cells proliferation. Thus, mechanistic insights into metabolic reprogramming may shed light upon NSCLC proliferation and find new proper targets for NSCLC treatment. Herein, we used loss- and gain-of-function experiments to uncover that highly expressed aldo-keto reductase family1 member C1 (AKR1C1) accelerated NSCLC cells proliferation via metabolic reprogramming. Further molecular profiling analyses demonstrated that AKR1C1 augmented the expression of hypoxia-inducible factor 1-alpha (HIF-1α), which could drive tumour metabolic reprogramming. What's more, AKR1C1 significantly correlated with HIF-1α signaling, which predicted poor prognosis for NSCLC patients. Collectively, our data display that AKR1C1 reprograms tumour metabolism to promote NSCLC cells proliferation by activating HIF-1α. These newly acquired data not only establish the specific role for AKR1C1 in metabolic reprogramming, but also hint to the possibility that AKR1C1 may be a new therapeutic target for NSCLC treatment.
- Published
- 2022
- Full Text
- View/download PDF
8. Upper ocean response to tropical cyclones: a review
- Author
-
Han Zhang, Hailun He, Wen-Zhou Zhang, and Di Tian
- Subjects
Tropical cyclone ,Upper ocean ,Dynamic response ,Temperature and salinity variation ,Marine biology ,Science ,Geology ,QE1-996.5 - Abstract
Abstract Tropical cyclones (TCs) are strong natural hazards that are important for local and global air–sea interactions. This manuscript briefly reviews the knowledge about the upper ocean responses to TCs, including the current, surface wave, temperature, salinity and biological responses. TCs usually cause upper ocean near-inertial currents, increase strong surface waves, cool the surface ocean, warm subsurface ocean, increase sea surface salinity and decrease subsurface salinity, causing plankton blooms. The upper ocean response to TCs is controlled by TC-induced mixing, advection and surface flux, which usually bias to the right (left) side of the TC track in the Northern (Southern) Hemisphere. The upper ocean response usually recovers in several days to several weeks. The characteristics of the upper ocean response mainly depend on the TC parameters (e.g. TC intensity, translation speed and size) and environmental parameters (e.g. ocean stratification and eddies). In recent decades, our knowledge of the upper ocean response to TCs has improved because of the development of observation methods and numerical models. More processes of the upper ocean response to TCs can be studied by researchers in the future.
- Published
- 2021
- Full Text
- View/download PDF
9. Tumor necrosis factor-related lncRNAs predict prognosis and immunotherapy response for patients with lung adenocarcinoma
- Author
-
Jin-Hua Chen, Xuan Wu, Zi-Ming Wang, Zi-Yang Liu, Bao-Xia He, Wen-Ping Song, and Wen-Zhou Zhang
- Subjects
Pulmonary and Respiratory Medicine - Published
- 2023
10. Dramatic response to immunotherapy in an epidermal growth factor receptor-mutant non-small cell lung cancer: A case report
- Author
-
Ding Li, Cheng Cheng, Wen-Ping Song, Pei-Zan Ni, Wen-Zhou Zhang, and Xuan Wu
- Subjects
Non-small cell lung cancer ,Case report ,Pemetrexed ,Immunotherapy ,General Medicine ,Epidermal growth factor receptor mutation ,respiratory tract diseases - Abstract
BACKGROUND The advent of immune checkpoint inhibitors (ICIs) has revolutionized the management of several types of solid cancers, including lung cancer, by boosting the body's natural tumor killing response. However, it is undeniable that only a small proportion of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations can achieve long-term responses and benefit from immunotherapy. CASE SUMMARY Herein, we report the case of a 48-year-old man diagnosed with stage IV lung adenocarcinoma with an EGFR L858R mutation who was administered pembrolizumab monotherapy followed by pemetrexed and achieved a 10-month progression-free survival interval. In this case report, we show that ICIs were effective for our patient with EGFR-mutated NSCLC and discuss the characteristics of patients who can benefit from immunotherapy. CONCLUSION We suggest that patients with EGFR-mutated NSCLC with high PD-L1 expression (defined as ≥ 25%), the L858R mutation, smoking history, or pemetrexed pretreatment may benefit from immunotherapy.
- Published
- 2021
11. Upper ocean response to tropical cyclones: a review
- Author
-
Di Tian, Han Zhang, Hailun He, and Wen-Zhou Zhang
- Subjects
010504 meteorology & atmospheric sciences ,Flux ,01 natural sciences ,Upper ocean ,lcsh:Science ,0105 earth and related environmental sciences ,Marine biology ,Tropical cyclone ,010505 oceanography ,Advection ,fungi ,lcsh:QE1-996.5 ,Plankton ,Salinity ,lcsh:Geology ,Temperature and salinity variation ,Oceanography ,Eddy ,Dynamic response ,Surface wave ,General Earth and Planetary Sciences ,Environmental science ,lcsh:Q ,geographic locations - Abstract
Tropical cyclones (TCs) are strong natural hazards that are important for local and global air–sea interactions. This manuscript briefly reviews the knowledge about the upper ocean responses to TCs, including the current, surface wave, temperature, salinity and biological responses. TCs usually cause upper ocean near-inertial currents, increase strong surface waves, cool the surface ocean, warm subsurface ocean, increase sea surface salinity and decrease subsurface salinity, causing plankton blooms. The upper ocean response to TCs is controlled by TC-induced mixing, advection and surface flux, which usually bias to the right (left) side of the TC track in the Northern (Southern) Hemisphere. The upper ocean response usually recovers in several days to several weeks. The characteristics of the upper ocean response mainly depend on the TC parameters (e.g. TC intensity, translation speed and size) and environmental parameters (e.g. ocean stratification and eddies). In recent decades, our knowledge of the upper ocean response to TCs has improved because of the development of observation methods and numerical models. More processes of the upper ocean response to TCs can be studied by researchers in the future.
- Published
- 2021
12. miR-3609 Decelerates the Clearance of Sorafenib in Hepatocellular Carcinoma Cells by Targeting EPAS-1 and Reducing the Activation of the Pregnane X Receptor Pathway
- Author
-
Jie Yang, Wen-Zhou Zhang, Qing-Ping Shao, and Chen Wei
- Subjects
0301 basic medicine ,Sorafenib ,molecular targeting agents ,endothelial PAS domain-containing protein 1 ,OncoTargets and Therapy ,pregnane X receptor ,03 medical and health sciences ,0302 clinical medicine ,Western blot ,microRNA ,Coactivator ,medicine ,Pharmacology (medical) ,Transcription factor ,Original Research ,Pregnane X receptor ,CYP3A4 ,medicine.diagnostic_test ,Chemistry ,hepatocellular carcinoma ,medicine.disease ,digestive system diseases ,030104 developmental biology ,Oncology ,microRNA-3609 ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Cancer research ,medicine.drug - Abstract
Qing-Ping Shao,1,* Chen Wei,2,* Jie Yang,3 Wen-Zhou Zhang1 1Department of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province 450008, People’s Republic of China; 2Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450052, People’s Republic of China; 3Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450052, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wen-Zhou ZhangDepartment of Pharmacy The Affiliated Cancer Hospital of Zhengzhou University, No. 127 Dongming Road,Jinshui District, Zhengzhou City, Henan Province, People’s Republic of ChinaTel/ Fax +86 371 65587240Email wenzhou_zhang2000@aliyun.comBackground: The pregnane X receptor (PXR) not only plays an important role in cellular metabolism processes but also induces the resistance of hepatocellular carcinoma (HCC) cells to molecularly targeted drugs by mediating their metabolism and clearance by these cells. Endothelial PAS domain-containing protein 1 (EPAS-1) acts as a coactivator to regulate the transcription factor activity of PXR. In the present study, a microRNA that potentially targets EPAS-1, namely miR-3609, was identified using the miRDB tool.Methods: The expression of miR-3609 and EPAS-1 was examined by qPCR. Lentiviral particles containing the full-length sequences of miR-3609 (pri-miR-3609) were prepared. The antitumor effect of antitumor agents was examined by the in vitro and in vivo assays.Results: The expression of miR-3609 was negatively correlated with that of EPAS-1 in both HCC clinical specimens and paired non-tumor specimens, and the effect of miR-3609 on the expression of EPAS-1 was confirmed by Western blot experiments. Overexpression of miR-3609 decreased the expression of EPAS-1 and, in turn, repressed the activation of the PXR pathway. miR-3609 decreased the transcription factor activation of PXR, repressed its recruitment to its target gene promoter regions, and decreased the expression of its target genes CYP3A4 and P-GP. In addition, miR-3609 decelerated the metabolism and clearance of sorafenib in HCC cells and enhanced the antitumor effect of sorafenib in HCC cells.Conclusion: Therefore, the results indicate that miR-3609 decreases the expression of EPAS-1 and enhances the sensitivity of HCC cells to sorafenib.Keywords: microRNA-3609, molecular targeting agents, endothelial PAS domain-containing protein 1, pregnane X receptor, hepatocellular carcinoma
- Published
- 2020
13. Remote sensing linear trends of the Gulf Stream from 1993 to 2016
- Author
-
Wen-Zhou Zhang, Lie Yauw Oey, Huijie Xue, and Fei Chai
- Subjects
010504 meteorology & atmospheric sciences ,010505 oceanography ,Climate change ,Oceanography ,01 natural sciences ,Latitude ,Gulf Stream ,Atmosphere ,North Atlantic oscillation ,Latent heat ,Climatology ,Period (geology) ,Environmental science ,Altimeter ,0105 earth and related environmental sciences - Abstract
The Gulf Stream (GS) transports a massive amount of heat northward to high latitudes and releases sensible and latent heat to the atmosphere, playing an important role in the North Atlantic and European climate change. The change trends of the GS transport and pathway are still uncertain to date. Our analyses of altimeter observations from 1993 to 2016 indicate that the linear trends in surface maximum speed, transport, and latitudinal location of the GS are significant east of 61° W at the 95% level while they are small and not significant between 72° W and 61° W. The weakening trend of the GS during the period from 1993 to 2016 is accompanied with a southward-shifting path, which is associated with the decline of the North Atlantic Oscillation (NAO) and possibly reduction in the Atlantic meridional overturning circulation (AMOC).
- Published
- 2020
14. Chaetoglobosin E inhibits tumor growth and promotes the anti-tumor efficacy of cytotoxic drugs in esophageal squamous cell carcinoma by targeting PLK1
- Author
-
Jin-Hua, Chen, Qing-Feng, Guo, Qiu-Ge, Liu, Bao-Xia, He, Wen-Ping, Song, Zhen-Hua, Yin, Dong-Bei, Li, Lin, Chen, and Wen-Zhou, Zhang
- Subjects
General Medicine - Abstract
Currently, there is no satisfactory treatment available for esophageal squamous cell carcinoma (ESCC), and thus, there is a pressing need to develop effective drugs. Chaetoglobosin E, a cytochalasan alkaloid derived from metabolites ofThe cytotoxic effect of chaetoglobosin E and cisplatin on esophageal cancer KYSE-30, KYSE-150, and TE-1 cells was detected using cell viability or colony formation assays. The cell cycle, apoptosis, autophagy, invasion, and metastasis were assayed by flow cytometry or western blot. The potential target of chaetoglobosin E was assayed by RNA sequencing (RNA-seq) and large loop prediction software analysis and was assessed by western blot and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). The effect of its target on cell pyroptosis was assayed using overexpression and silence experiments.Chaetoglobosin E significantly inhibited the proliferation of KYSE-30, KYSE-150, and TE-1 cells, especially KYSE-30 cells. Our results showed that chaetoglobosin E induced the G2/M phase arrest of KYSE-30 cells, followed by the down-regulation of cyclinB1, CDC2, and p-CDC2, and up-regulation of p21. Moreover, chaetoglobosin E also decreased the anti-apoptotic protein expression of Bcl-2, increased apoptotic expression of Bax, increased autophagy protein expressions of beclin1 and LC3, decreased invasion and metastasis protein expression of E-cadherin, and increased expression of vimentin. The RNA-seq and large loop prediction software analysis results indicated that its potential target might be polo-like kinase 1 (PLK1). Moreover, results also showed that chaetoglobosin E can reverse the PLK1 overexpression plasmid-induced up-regulation of the PLK1 protein. Furthermore, we found that chaetoglobosin E induced pyroptosis via the activation of the gasdermin E (GSDME) protein. Further studies showed that the high expression of PLK1 inactivated the GSDME protein, while the knockdown of PLK1 expression activated the GSDME protein, indicating that chaetoglobosin E induced cell pyroptosis by inhibiting PLK1.This study suggested that chaetoglobosin E may be a novel lead compound to the treatment of ESCC patients by targeting PLK1, and elucidated for the first time that PLK1 was involved in a new pyroptosis mechanism.
- Published
- 2022
15. An extreme warm event of the Yellow Sea Cold Water Mass in the summer of 2007 and its causes
- Author
-
Hui Zheng and Wen-Zhou Zhang
- Subjects
Atmospheric Science ,Computer Science (miscellaneous) ,Geotechnical Engineering and Engineering Geology ,Oceanography - Published
- 2022
16. Evaluating the Roles of Wind‐ and Buoyancy Flux‐Induced Mixing on Phytoplankton Dynamics in the Northern and Central South China Sea
- Author
-
Wen-Zhou Zhang, Peng Xiu, Dongxiao Wang, Bingxu Geng, Shiyu Li, Chan Shu, and Fei Chai
- Subjects
Buoyancy flux ,Geophysics ,Oceanography ,South china ,Space and Planetary Science ,Geochemistry and Petrology ,Dynamics (mechanics) ,Phytoplankton ,Earth and Planetary Sciences (miscellaneous) ,Environmental science ,Mixing (physics) - Published
- 2019
17. AKR1C1 connects autophagy and oxidative stress by interacting with SQSTM1 in a catalytic-independent manner
- Author
-
Qiaojun He, Lin-Lin Chang, Pei-Hua Lu, Chen-Ming Zeng, Chenxi Zhao, Wen-Zhou Zhang, Fujing Ge, Jiamin Du, Hong Zhu, Bo Yang, and Yue-Kang Li
- Subjects
0301 basic medicine ,Lung Neoplasms ,AKR1C1 ,Aldo-Keto Reductases ,medicine.disease_cause ,Article ,03 medical and health sciences ,0302 clinical medicine ,Sequestosome 1 ,Carcinoma, Non-Small-Cell Lung ,Cell Line, Tumor ,Sequestosome-1 Protein ,medicine ,Autophagy ,Humans ,Pharmacology (medical) ,education ,Receptor ,Pharmacology ,chemistry.chemical_classification ,Reactive oxygen species ,education.field_of_study ,Chemistry ,General Medicine ,Cell biology ,Oxidative Stress ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer development ,Flux (metabolism) ,Oxidative stress - Abstract
Targeting autophagy might be a promising anticancer strategy; however, the dual roles of autophagy in cancer development and malignancy remain unclear. NSCLC (non-small cell lung cancer) cells harbour high levels of SQSTM1 (sequestosome 1), the autophagy receptor that is critical for the dual roles of autophagy. Therefore, mechanistic insights into SQSTM1 modulation may point towards better approaches to treat NSCLC. Herein, we used multiple autophagy flux models and autophagy readouts to show that aldo-keto reductase family 1 member C1 (AKR1C1), which is highly expressed in NSCLC, promotes autophagy by directly binding to SQSTM1 in a catalytic-independent manner. This interaction may be strengthened by reactive oxygen species (ROS), important autophagy inducers. Further mechanistic research demonstrated that AKR1C1 interacts with SQSTM1 to augment SQSTM1 oligomerization, contributing to the SQSTM1 affinity for binding cargo. Collectively, our data reveal a catalytic-independent role of AKR1C1 for interacting with SQSTM1 and promoting autophagy. All these findings not only reveal a novel functional role of AKR1C1 in the autophagy process but also indicate that modulation of the AKR1C1-SQSTM1 interaction may be a new strategy for targeting autophagy. [Image: see text]
- Published
- 2020
18. Composite eddy structures on both sides of the Luzon Strait and influence factors
- Author
-
Wen-Zhou Zhang, Qinbiao Ni, and Huijie Xue
- Subjects
010504 meteorology & atmospheric sciences ,010505 oceanography ,Advection ,Anomaly (natural sciences) ,Temperature salinity diagrams ,Oceanography ,01 natural sciences ,Salinity ,Eddy ,Anticyclone ,Surface layer ,Geomorphology ,Argo ,Geology ,0105 earth and related environmental sciences - Abstract
Combining Argo observations with satellite remote sensing data during the period of 2002–2014, the mean three-dimensional structures of mesoscale eddies on both sides of the Luzon Strait (LS) were obtained via a composite method and analyzed to statistically examine the influences of background marine environment and the Kuroshio current on the eddy structures. The significant signals of temperature and salinity anomalies within the composite eddies extend much deeper in the region east of the LS (zone E) than those in the region west of the strait (zone W) because of stronger eddy intensity and larger vertical gradients of background temperature and salinity in the deep layer in zone E. In the vertical structure of temperature anomaly within the eddies, two cores occur at around 200 and 400 dbar depths, respectively, in zone E and only one core is centered at about 100 dbar in zone W. There is a clear three-core sandwich pattern in the vertical structure of salinity anomaly within the eddies in zone E. The Kuroshio water trapped in the eddy is responsible for abnormally positive salinity anomaly in the surface layer of the anticyclonic eddy center in zone W. On both sides of the LS, an asymmetric dipole structure in the surface layer gradually turns into a monopole one at depths, which resulted from the competition between horizontal advection effect and eddy pumping effect. The Kuroshio current influences the distribution patterns of isotherms and isohalines and enhances background temperature and salinity horizontal gradients on both sides of the LS, determining the orientations of dipole temperature and salinity structures within eddies.
- Published
- 2018
19. Ocean response to typhoons in the western North Pacific: Composite results from Argo data
- Author
-
Sheng Lin, Wen-Zhou Zhang, Huasheng Hong, and Shaoping Shang
- Subjects
010504 meteorology & atmospheric sciences ,010505 oceanography ,Aquatic Science ,Oceanography ,01 natural sciences ,Salinity ,Sea surface temperature ,Water column ,Typhoon ,Climatology ,Upwelling ,Surface layer ,Tropical cyclone ,Geology ,Argo ,0105 earth and related environmental sciences - Abstract
Composite structures of ocean temperature and salinity anomalies caused by tropical cyclones (TCs) or typhoons in the western North Pacific Ocean were obtained from Argo data. These structures were used to analyze ocean responses to typhoons and the dynamic mechanisms inherent in those responses with a particular focus on upwelling. TC-induced cooling is often strongly rightward-biased in the surface layer, and shifts toward the typhoon track at depths exceeding roughly 100 m. In the central water column within approximately 75 km of the typhoon track, subsurface warming predicted by vertical mixing is restrained and replaced by cooling due to upwelling. Upwelling contributes 15% on average to temperature cooling in the near surface layer (10–30 m), 84% in the subsurface layer (30–250 m) and 94% in the deep layer (250–600 m) during the period of 0.5–2.5 days after the typhoon's passage. It is suggested that the sea surface cooling effect of vertical mixing can be enhanced by the upwelling. The effect of upwelling is also prominent in the salinity response to typhoons. The composite results from the Argo data clearly reveal basic ocean responses to typhoons and indicate the important role of upwelling therein.
- Published
- 2017
20. Physical drivers of chlorophyll variability in the open South China Sea
- Author
-
Guoqiang Qiu, Wen-Zhou Zhang, Haili Wang, and Fei Chai
- Subjects
0106 biological sciences ,Chlorophyll a ,geography ,geography.geographical_feature_category ,010504 meteorology & atmospheric sciences ,Advection ,Continental shelf ,010604 marine biology & hydrobiology ,Structural basin ,Oceanography ,01 natural sciences ,Algal bloom ,chemistry.chemical_compound ,Sea surface temperature ,Geophysics ,chemistry ,Space and Planetary Science ,Geochemistry and Petrology ,Phytoplankton ,Earth and Planetary Sciences (miscellaneous) ,Environmental science ,Surface layer ,0105 earth and related environmental sciences - Abstract
The variability of chlorophyll a concentration (Chl a) in the open South China Sea (SCS) was examined using observations from two Bio-Argo floats. During the period of September 2014 to August 2015, there was a permanent subsurface Chl a maximum (SCM) in the depth range of 48 to 96 m in the central basin of the SCS. In the northern basin, the SCM disappeared in winter, replaced by enhanced surface layer phytoplankton with high Chl a. The values of the SCM were influenced by the vertical displacement of isotherms. Strong wind forcing and surface cooling were the main physical drivers of high surface Chl a in winter. In the north, stronger wind than in the center, lower sea surface temperature (SST) than in the center, and Kuroshio water intrusion were more favorable for the upward transport of nutrient-rich deep water. A large amount of nitrate could be advected from the Taiwan Strait and shallow continental shelf to the northern basin in winter. A combination of strong wind mixing, surface cooling, Kuroshio water intrusion, and horizontal advection caused the winter surface phytoplankton bloom in the north. This article is protected by copyright. All rights reserved.
- Published
- 2016
21. Silencing the expression of copine-III enhances the sensitivity of hepatocellular carcinoma cells to the molecular targeted agent sorafenib
- Author
-
Bao-xia He, Zheng-kui Jiang, Zhuo Chen, and Wen-zhou Zhang
- Subjects
0301 basic medicine ,Sorafenib ,Multidrug Resistance Process ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,molecular targeted agent ,medicine ,Gene silencing ,copine-III ,sorafenib-resistance ,neoplasms ,Original Research ,business.industry ,CPNE3 ,Cancer ,Transfection ,hepatocellular carcinoma ,medicine.disease ,digestive system diseases ,030104 developmental biology ,Real-time polymerase chain reaction ,Oncology ,Cancer Management and Research ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Cancer research ,business ,medicine.drug - Abstract
Zhuo Chen, Zhengkui Jiang, Wenzhou Zhang, Baoxia He The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou 450008, People’s Republic of China Background: The application of the oral targeted therapeutic agent sorafenib provides new hope for patients suffering from advanced stages of hepatocellular carcinoma (HCC), but the prognosis of such patients remains poor due to the rapid development of the multidrug resistance process in cancer pathogenesis. The present work evaluated whether copine-III, a novel cancer regulator encoded by the CPNE3 gene, would be a potential indicator of sorafenib resistance in HCC treatment.Materials and methods: The endogenous expression of copine-III in clinical specimens was examined by quantitative polymerase chain reaction. Copine-III siRNA was transfected into HCC cells to downregulate copine-III expression. The effect of copine-III on sorafenib’s antitumor activation was identified by in vitro and in vivo experiments (MTT, Transwell, and flow cytometry as well as a nude mice model).Results: High levels of copine-III in clinical specimens are related to poor prognosis of advanced HCC patients on sorafenib treatment. Infection of Ad-siCPNE3 significantly decreased the endogenous expression of copine-III and enhanced the susceptibility of MHCC97-H cells to sorafenib: the IC50 value decreased from 1.15±0.11 to 0.25±0.05 μmol/L. Moreover, silencing copine-III enhanced the effect of sorafenib on apoptosis, in vitro invasion/migration, and subcutaneous or intrahepatic growth of MHCC97-H cells in nude mice.Conclusion: Copine-III is a novel potential indicator of prognosis for patients who received sorafenib for advanced HCC treatment. Keywords: hepatocellular carcinoma, CPNE3, copine-III, molecular targeted agent, sorafenib-resistance
- Published
- 2018
22. The impact of Kuroshio water on the source water of the southeastern Taiwan Strait: numerical results
- Author
-
Ting-Hsuan Huang, Xue-Fen Zhuang, Wen-Zhou Zhang, and Chen-Tung Arthur Chen
- Subjects
geography ,South china ,geography.geographical_feature_category ,Wind stress ,Aquatic Science ,Seasonality ,Oceanography ,medicine.disease ,Impact index ,La Niña ,Source water ,Climatology ,Spring (hydrology) ,medicine ,Environmental science ,Seawater - Abstract
Model output from a Pacific basin-wide three-dimensional physical-biogeochemical model during the period of 1991 to 2008 was used to investigate the impact of Kuroshio water on the source water of the southeastern Taiwan Strait. Based on the characteristic salinities of both Kuroshio water and the South China Sea water, a Kuroshio impact index (KII) was designed to measure the degree of impact. The KII correlates significantly with the northeast-southwest component of wind stress, but the former lags the latter by approximately two months. The correlation coefficient between them increases from 0.267 4 to 0.852 9, with a lag time increasing from 0 to 63 days. The impact of Kuroshio Water is greater in winter and spring than in summer and autumn. At the interannual time scale, El Nino and La Nina events play an important role in impacting the KII. During El Nino events, more Kuroshio water contributes to the source water of the southeastern Taiwan Strait. Conversely, during La Nina events, less Kuroshio water contributes to the source water.
- Published
- 2015
23. Varying intensity of Kuroshio intrusion into Southeast Taiwan Strait during ENSO events
- Author
-
Wen-Zhou Zhang, Ting-Hsuan Huang, Xue-Fen Zhuang, and Chen-Tung Arthur Chen
- Subjects
geography ,geography.geographical_feature_category ,Ocean current ,Geology ,Aquatic Science ,Oceanography ,Monsoon ,Salinity ,La Niña ,Environmental science ,Seawater ,Hydrography ,Channel (geography) ,Teleconnection - Abstract
The Taiwan Strait is the only direct passage between the South China Sea (SCS) and the East China Sea. Variations in the intensity of Kuroshio Branch and surface currents in the SCS result in seasonal and inter-annual variability in the hydrography of the SE Taiwan Strait, where the northwardly pointing funnel-like Penghu Channel is located. These currents vary with the intensity and direction of monsoons. The teleconnection between air-sea interaction of the east Pacific and west Pacific reportedly has time differences. The data in this study reveal that the salinity of the seawater in the Penghu Channel is highest during El Nino events with a seven-month lag to the monthly Nino 3.4 index, and lowest during La Nina periods, also with a lag of seven months to the monthly Nino 3.4 index. The chemical parameters also vary with these events. The concentrations of apparent oxygen utilization, nutrients, and hydrogen ions vary with the mixing ratio of SCS water and Kuroshio Branch water. The maximum concentrations of nutrients are significantly higher during the summer, seven months after a La Nina event (La Nina-7), than in other seasons. However, biological activities also affected these chemical parameters. In spring, active photosynthesis consumes more nutrients and hydrogen ion concentrations in La Nina-7 periods than in normal-7 periods.
- Published
- 2015
24. Dynamical processes within an anticyclonic eddy revealed from Argo floats
- Author
-
Wen-Zhou Zhang, Fei Chai, Huijie Xue, and Qinbiao Ni
- Subjects
Momentum (technical analysis) ,Mixed layer ,Physics::Geophysics ,Physics::Fluid Dynamics ,Geophysics ,Oceanography ,Eddy ,Downwelling ,Anticyclone ,Phytoplankton ,General Earth and Planetary Sciences ,Upwelling ,Physics::Atmospheric and Oceanic Physics ,Argo ,Geology - Abstract
Mesoscale eddies play a significant role in supplying the nutrients required for phytoplankton blooms and redistributing biomass in the ocean. However, how eddies influence nutrient flux and biomass distribution remains unclear. Here we reveal two important dynamical processes (radial displacement and vertical fluctuations) within an anticyclonic eddy by analyzing observations from Argo floats. The Argo floats in the eddy were displaced toward the eddy edge due to the imbalance of radial momentum. Vertical fluctuations below the mixed layer resulted in alternating upwelling and downwelling in the inner and outer parts of the eddy. High salinity deep water was uplifted tens of meters by the upwelling and further extended to the surface with the aid of wind effects. Vertical motions associated with the fluctuations penetrated to the depths of several hundred meters. These processes represent crucial dynamical mechanisms for the motion of particles in mature anticyclonic eddies.
- Published
- 2015
25. Volume transport through the Taiwan Strait and the effect of synoptic events
- Author
-
Huasheng Hong, Fei Chai, Huijie Xue, and Wen-Zhou Zhang
- Subjects
Waves and shallow water ,Volume (thermodynamics) ,Atmospheric pressure ,Climatology ,Typhoon ,Synoptic scale meteorology ,Environmental science ,High temporal resolution ,Wind stress ,Magnitude (mathematics) ,Geology ,Aquatic Science ,Oceanography - Abstract
Volume transport through the Taiwan Strait during 2005–2008 was simulated using a shallow water model forced by high spatio-temporal resolution meteorological data. On average, simulated monthly mean transports ranged from a southward maximum of 0.38 Sv in December to a northward maximum of 2.02 Sv in June, with an annual mean northward transport of 0.78 Sv. These estimates are in agreement with the published results based on bottom-mounted ADCP observations. Several sensitivity experiments were conducted to separately examine possible influence of ignoring air pressure or applying time-averaged wind forcing on the transport estimate. We found that excluding the air pressure component in the model gave rise to an insignificant difference (0.01 Sv) in the mean transport estimate. Using multi-year-averaged monthly mean wind, however, provided markedly different results; it brought about a magnitude change of up to 0.65 Sv for the monthly mean transport and 0.34 Sv for the annual mean transport. The nonlinear parameterization of wind stress was mainly responsible for the distortion. In addition, we found that typhoons, as one kind of synoptic events, had an accumulative influence not only on the monthly mean transport during the typhoon season but also on the annual mean transport. The effect of typhoons reduced the monthly mean transport by up to 0.45 Sv and the annual mean transport by 0.09 Sv (more than 10%). Therefore, high temporal resolution wind data with synoptic scale variability are required to accurately estimate the monthly mean and annual mean transports when using a model.
- Published
- 2014
26. Influence of Tropical Cyclones in the Western North Pacific
- Author
-
Wen-Zhou Zhang, Sheng Lin, and Xue-Min Jiang
- Subjects
Cold-core low ,Climatology ,Tropical wave ,Tropical cyclone basins ,Environmental science ,Westerlies ,Pacific hurricane ,Tropical cyclone ,African easterly jet ,Monsoon trough - Abstract
The Western North Pacific (WNP) is the most favorable area in the world for the generation of tropical cyclones (TCs). As the most intense weather system, TCs play an important role in the change of ocean environment in the WNP. Based on many investigations published in the literature, we obtained a collective and systematic understanding of the influence of TCs on ocean components in the WNP, including sea temperature, ocean currents, mesoscale eddies, storm surges, phytoplankton (indicated by chlorophyll a). Some ocean responses to TCs are unique in the WNP because of the existence of the Kuroshio and special geographical configurations such as the South China Sea.
- Published
- 2016
27. Typhoons enhancing northward transport through the Taiwan Strait
- Author
-
Xiao-Hai Yan, Wen-Zhou Zhang, and Huasheng Hong
- Subjects
Engineering ,Oceanography ,Meteorology ,business.industry ,Typhoon ,Natural science ,Foundation (engineering) ,Geology ,Aquatic Science ,China ,business - Abstract
National Natural Science Foundation of China [41076002, 41276007]; Fundamental Research Funds for the Central Universities [2010121036]; Science Foundation of Fujian Province [2010Y0064]; Public Science and Technology Research Funds Projects of Ocean [200905013-7]
- Published
- 2013
28. A two-way nested coupled tide-surge model for the Taiwan Strait
- Author
-
De-Wen Chen, Wen-Zhou Zhang, Shaoping Shang, Fei Chai, and Huasheng Hong
- Subjects
Meteorology ,Mode (statistics) ,Wind stress ,Storm surge ,Geology ,Aquatic Science ,Oceanography ,Nested set model ,Coupling effect ,Climatology ,Typhoon ,Forecast period ,Surge - Abstract
A two-way nested coupled tide-surge prediction model was established and applied in the Taiwan Strait and adjacent sea area in this study. This two-dimensional (2D) model had a fine horizontal resolution and took into account the interaction between storm surges and astronomical tides, which made it suitable for depicting the complicated physical properties of storm surges in the Taiwan Strait. A two-way nesting technique and an open boundary condition developed from Flather's radiation condition and Roed and Smedstad's local mode idea, were successfully implemented in the model. A simulation experiment showed that the open boundary condition could be used in the coupled tide-surge model and that the performance of the two-way nested model was slightly superior in accuracy to that of the one-way nested one. The fluctuations of storm surge residuals with tidal period at Sansha and Pingtan tide stations during the period of typhoon Dan in 1999 were well reproduced by the model, with the coupling effect between storm surges and tides indicating that the effect of astronomical tides upon typhoon surges should be considered in a storm-surge prediction model for the Taiwan Strait. The forecast experiment during typhoon Talim in 2005 showed that the storm surge prediction outputs by the model were better in the early 20 h of the forecast period of each model run than those in the later period due to the prediction accuracy of the typhoon track, maximum winds, and central air pressures.
- Published
- 2007
29. Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling
- Author
-
Wen-zhou Zhang, Xian-ben Liu, Bao-xia He, and Zheng-kui Jiang
- Subjects
Lipopolysaccharides ,Male ,Lipopolysaccharide ,MAP Kinase Signaling System ,Immunology ,Acute Lung Injury ,Nitric Oxide Synthase Type II ,Pharmacology ,Lung injury ,medicine.disease_cause ,Protective Agents ,Lignans ,Article ,Superoxide dismutase ,chemistry.chemical_compound ,Mice ,medicine ,Immunology and Allergy ,Animals ,Furans ,Arctigenin ,chemistry.chemical_classification ,arctigenin ,biology ,medicine.diagnostic_test ,Glutathione peroxidase ,lipopolysaccharide ,Membrane Proteins ,respiratory system ,heme oxygenase ,respiratory tract diseases ,Mice, Inbred C57BL ,Disease Models, Animal ,Oxidative Stress ,Bronchoalveolar lavage ,chemistry ,inflammation ,biology.protein ,Glutathione disulfide ,Oxidative stress ,Heme Oxygenase-1 - Abstract
Arctigenin, a bioactive component of Arctium lappa (Nubang), has anti-inflammatory activity. Here, we investigated the effects of arctigenin on lipopolysaccharide (LPS)-induced acute lung injury. Mice were divided into four groups: control, LPS, LPS + DMSO, and LPS + Arctigenin. Mice in the LPS + Arctigenin group were injected intraperitoneally with 50 mg/kg of arctigenin 1 h before an intratracheal administration of LPS (5 mg/kg). Lung tissues and bronchoalveolar lavage fluids (BALFs) were collected. Histological changes of the lung were analyzed by hematoxylin and eosin staining. Arctigenin decreased LPS-induced acute lung inflammation, infiltration of inflammatory cells into BALF, and production of pro-inflammatory cytokines. Moreover, arctigenin pretreatment reduced the malondialdehyde level and increased superoxide dismutase and catalase activities and glutathione peroxidase/glutathione disulfide ratio in the lung. Mechanically, arctigenin significantly reduced the production of nitric oxygen and inducible nitric oxygen synthase (iNOS) expression, enhanced the expression of heme oxygenase-1, and decreased the phosphorylation of mitogen-activated protein kinases (MAPKs). Arctigenin has anti-inflammatory and antioxidative effects on LPS-induced acute lung injury, which are associated with modulation of MAPK, HO-1, and iNOS signaling.
- Published
- 2015
30. Tide-surge Interaction Intensified by the Taiwan Strait
- Author
-
Shaoping Shang, Wen-Zhou Zhang, Huasheng Hong, Fengyan Shi, and James T. Kirby
- Subjects
Atmospheric Science ,Ecology ,Paleontology ,Soil Science ,Storm surge ,Forestry ,Storm ,Aquatic Science ,Oceanography ,Geophysics ,Geography ,Space and Planetary Science ,Geochemistry and Petrology ,General partnership ,Typhoon ,Climatology ,Earth and Planetary Sciences (miscellaneous) ,Tide gauge ,Tropical cyclone ,China ,Earth-Surface Processes ,Water Science and Technology ,Typhon - Abstract
Science Foundation of Fujian Province [2009J01223]; National High-tech RD Program [2006AA09A302-6]; National Oceanographic Partnership Program [N00014-06-1-0945]
- Published
- 2010
31. Strong southward transport events due to typhoons in the Taiwan Strait
- Author
-
Wen-Zhou Zhang, Fei Chai, Huasheng Hong, Xiao-Hai Yan, and Shaoping Shang
- Subjects
Atmospheric Science ,Ecology ,Foundation (engineering) ,Paleontology ,Soil Science ,Forestry ,Numerical models ,Aquatic Science ,Oceanography ,Geophysics ,Geography ,Space and Planetary Science ,Geochemistry and Petrology ,Wind effect ,Climatology ,Typhoon ,Earth and Planetary Sciences (miscellaneous) ,Tropical cyclone ,Far East ,China ,Earth-Surface Processes ,Water Science and Technology ,Typhon - Abstract
China Postdoctoral Science Foundation [20070420745]; Science Foundation of Fujian Province [2009J01223]; National High-Tech Research and Development [2006AA09A302-6]
- Published
- 2009
32. The embedded desktop augmented reality system based on ADSP-BF561
- Author
-
Da-yuan Yan, Dong Zhang, Wen-zhou Zhang, and Chun Wang
- Subjects
Engineering ,business.industry ,Orientation (computer vision) ,Optical head-mounted display ,Image processing ,Display device ,Data acquisition ,Computer graphics (images) ,Computer vision ,Augmented reality ,Artificial intelligence ,Image sensor ,business ,Digital signal processing - Abstract
The traditional tabletop AR systems general use head mounted display (HMD) that has some shortcomings, such as the imprecise precision and low flexibility. To solve these problems, a new design of video see-through tabletop system based on ADSP-BF561 [1,2] is presented, it can fix the display system on the end of the orientation system, that made up of mechanism and angle sensor, and move in a circular area measured by pole length, observe every orientation. These implemented system registration, image collection, transmission and display.
- Published
- 2007
33. Design about a desktop augmented reality system network transmission based on ADSP-BF561
- Author
-
Yang Zhang, Da-yuan Yan, Wen-zhou Zhang, Chun Wang, and Da-ming Zhang
- Subjects
Ar system ,business.industry ,Computer science ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,Data_CODINGANDINFORMATIONTHEORY ,Transmission system ,Transmission (telecommunications) ,Embedded system ,Software design ,Augmented reality ,business ,Computer hardware ,Data transmission - Abstract
Network transmission is of great effect to capability of the desktop AR system, so speed and veracity of network transmission is very important. This article introduces hardware and software design about the network transmission system and experimental result shows that both speed and veracity of network transmission can satisfy the requirement of image data transmission in desktop AR system.
- Published
- 2007
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.