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The meteorological date from 26 meteorological station in the endorheic area in Alpine region were analyzed by means of liner regression method， 5-year moving average analysis method to get spatial and temporal variations of air temperature in the region， from 1969 to 2013.The result show that： （1） The endorheic area in Alpine region shows a warming trend from 1969 to 2017.Annual mean air temperature， mean maximum and mean minimum temperature had increased significantly， and the warming rate of minimum temperature is almost 1.5 times of that of maximum temperature.The spatial distribution of maximum temperature and minimum temperature increased from southeast to northwest.（2） The 12 extreme temperature indices showed statistically warming from 1961 to 2017.Warming indexes and GSL shows significant increasing while the some cooling indexes （TN10P、 TX10P）， ID， FD and DTR shows decreasing since mid-1960s.The spatial distribution of GSL， warm indices and some cold indices （TXN） increases in the north of the endorheic area in Alpine region， and the spatial distribution of FD and ID show significant increases in the south and southwest of the endorheic area in Alpine region.（3） The decrease of cooling indices was larger than the increase of warming indices， and the decrease of night indices was larger than the increase of day indices.（4） Extreme high temperature index （TXX， TXN） in the endorheic area in Alpine region is greatly affected by altitude， and the extreme temperature indices in the endorheic area in Alpine region has a warming trend， when the increased area， the high edge of regression and the increased intensity of the Atlantic subtropical high， or the increased intensity and the eastern position of the western Pacific subtropical high.