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4. Effectiveness of subcutaneous monoclonal antibody treatment in emergency department outpatients with COVID‐19

Author

Wendel, Sarah K., primary, Wogu, Adane F., additional, Carlson, Nichole E., additional, Beaty, Laurel, additional, Bennett, Tellen D., additional, Bookman, Kelly, additional, Mayer, David A., additional, Michael, Sean M., additional, Molina, Kyle C., additional, Peers, Jennifer L., additional, Russell, Seth, additional, Zane, Richard D., additional, and Ginde, Adit A., additional

Published
2024
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5. Improved outpatient follow‐up after implementation of emergency department–based physical therapy.

Author

Sommers, Stuart, Wendel, Sarah, Greig, Alex, Barbour, Aaron, Griffith, Rebekah, Magdaleno, Mark, Skaggs, Michael, Michael, Sean, Bookman, Kelly, Tolle, Heather, and Hoppe, Jason

Subjects
PHYSICAL therapy, HOME care services, HUMAN services programs, OUTPATIENT services in hospitals, ACADEMIC medical centers, T-test (Statistics), EMERGENCY room visits, HOSPITAL emergency services, RETROSPECTIVE studies, CHI-squared test, DESCRIPTIVE statistics, MEDICAL records, ACQUISITION of data, DATA analysis software, PATIENT aftercare, MEDICAL practice, MEDICAL referrals
Abstract

The article focuses on a study on the impact of emergency department(ED)-based physical therapy (PT) (ED-PT) on PT access in both ED and outpatient settings. Topics discussed include the methods used in the study, the rates of outpatient PT referral and success outpatient PT participation, and conclusion of the study.

Published
2024
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6. Alternative Ultrasound Gel for a Sustainable Ultrasound Program: Application of Human Centered Design.

Author

Salmon, Margaret, Salmon, Christian, Bissinger, Alexa, Muller, Mundenga, Gebreyesus, Alegnta, Geremew, Haimanot, Wendel, Sarah, Azaza, Aklilu, Salumu, Maurice, and Benfield, Nerys

Subjects
Africa, Costs and Cost Analysis, Equipment Design, Gels, Humans, Manihot, Program Evaluation, Ultrasonics
Abstract

This paper describes design of a low cost, ultrasound gel from local products applying aspects of Human Centered Design methodology. A multidisciplinary team worked with clinicians who use ultrasound where commercial gel is cost prohibitive and scarce. The team followed the format outlined in the Ideo Took Kit. Research began by defining the challenge how to create locally available alternative ultrasound gel for a low-resourced environment? The End-Users, were identified as clinicians who use ultrasound in Democratic Republic of the Congo and Ethiopia. An expert group was identified and queried for possible alternatives to commercial gel. Responses included shampoo, oils, water and cornstarch. Cornstarch, while a reasonable solution, was either not available or too expensive. We then sought deeper knowledge of locally sources materials from local experts, market vendors, to develop a similar product. Suggested solutions gleaned from these interviews were collected and used to create ultrasound gel accounting for cost, image quality, manufacturing capability. Initial prototypes used cassava root flour from Great Lakes Region (DRC, Rwanda, Uganda, Tanzania) and West Africa, and bula from Ethiopia. Prototypes were tested in the field and resulting images evaluated by our user group. A final prototype was then selected. Cassava and bula at a 32 part water, 8 part flour and 4 part salt, heated, mixed then cooled was the product design of choice.

Published
2015

7. Failure to Identify HIV-Infected Individuals in a Clinical Trial Using a Single HIV Rapid Test for Screening

Author

Piwowar-Manning, Estelle, Fogel, Jessica M, Laeyendecker, Oliver, Wolf, Shauna, Cummings, Vanessa, Marzinke, Mark A, Clarke, William, Breaud, Autumn, Wendel, Sarah, Wang, Lei, Swanson, Priscilla, Hackett, John, Mannheimer, Sharon, del Rio, Carlos, Kuo, Irene, Harawa, Nina T, Koblin, Beryl A, Moore, Richard, Blankson, Joel N, and Eshleman, Susan H

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Immunology, HIV/AIDS, Prevention, Clinical Trials and Supportive Activities, Clinical Research, Infectious Diseases, Infection, Adult, Anti-HIV Agents, Antibodies, Viral, Blotting, Western, Cohort Studies, False Negative Reactions, Female, HIV Infections, HIV-1, Humans, Immunoassay, Male, Mass Screening, Middle Aged, RNA, Viral, Sensitivity and Specificity, Viral Load, antiretroviral therapy, elite controller, HIV, rapid test, viral suppression, Virology, Clinical sciences
Abstract

BackgroundIn the HIV Prevention Trials Network (HPTN) 061 study, 8 (2.3%) of 348 HIV-infected participants identified as HIV uninfected at study enrollment using a single HIV rapid test for screening were found to be HIV infected after additional testing.ObjectivesTo evaluate the performance of different HIV assays for detection of HIV infection in HPTN 061 participants with missed infection and individuals with viral suppression.MethodsPlasma samples from 8 HPTN 061 participants, 17 elite controllers, and 101 individuals on antiretroviral treatment (ART) were tested for HIV with 3 rapid tests, 2 laboratory-based immunoassays, and a Western blot assay. The HPTN 061 samples were also tested with 2 HIV RNA assays and an antiretroviral drug assay.ResultsOf the 8 HPTN 061 participants with missed infection, 1 was an elite controller, 1 was taking ART, 2 were missed because of testing or clerical errors, 1 had recent HIV infection (identified using a multi-assay algorithm), and 3 had acute HIV infection. Two (1.7%) of 118 individuals with viral suppression (both taking ART) had at least 1 false-negative test.ConclusionsIn clinical trials, HIV infections can be missed for a variety of reasons. Using more than one assay to screen for HIV infection may reduce the number of missed infections.

Published
2014

9. Emergency department hospice care pathway associated with decreased ED and hospital length of stay.

Author

Wendel, Sarah K., Whitcomb, Mackenzie, Solomon, Ariel, Swafford, Angela, Youngwerth, Jeanie, Wiler, Jennifer L., and Bookman, Kelly

Abstract

While increasing evidence shows that hospice and palliative care interventions in the ED can benefit patients and systems, little exists on the feasibility and effectiveness of identifying patients in the ED who might benefit from hospice care. Our aim was to evaluate the effect of a clinical care pathway on the identification of patients who would benefit from hospice in an academic medical center ED setting. We instituted a clinical pathway for ED patients with potential need for or already enrolled in hospice. This pathway was digitally embedded in the electronic health record and made available to ED physicians, APPs and staff in a non-interruptive fashion. Patient and visit characteristics were evaluated for the six months before (05/04/2021–10/4/2021) and after (10/5/2021–05/04/2022) implementation. After pathway implementation, more patients were identified as appropriate for hospice and ED length of stay (LOS) for qualifying patients decreased by a median of 2.9 h. Social work consultation for hospice evaluation increased, and more patients were discharged from the ED with hospice. As more patients were identified with end-of-life care needs, the number of patients admitted to the hospital increased. However, more patients were admitted under observation status, and admission LOS decreased by a median of 18.4 h. This non-interruptive, digitally embedded clinical care pathway provided guidance for ED physicians and APPs to initiate hospice referrals. More patients received social work consultation and were identified as hospice eligible. Those patients admitted to the hospital had a decrease in both ED and hospital admission LOS. [ABSTRACT FROM AUTHOR]

Published
2024
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11. ED-based COVID-19 vaccination campaign finds higher vaccination rates for individuals from racial and ethnic minority groups compared with clinic setting.

Author

Wendel, Sarah K, Jackson, Conner L, Resnick-Ault, Daniel, Jacknin, Gabrielle, Zane, Richard D, Michael, Sean S, Bookman, Kelly J, and Ginde, Adit A

Subjects
HOSPITAL emergency services, COVID-19, IMMUNIZATION, MINORITIES, ACADEMIC medical centers, COVID-19 vaccines, RACE, VACCINATION coverage, RETROSPECTIVE studies, COMPARATIVE studies, DESCRIPTIVE statistics, SOCIODEMOGRAPHIC factors, ELECTRONIC health records, METROPOLITAN areas, DATA analysis software, SECONDARY analysis
Abstract

Background Emergency department visits associated with Coronavirus Disease 2019 (COVID-19) continue to indicate racial and ethnic inequities. We describe the sociodemographic characteristics of individuals receiving COVID-19 vaccination in the emergency department and compare with an outpatient clinic population and emergency department (ED) patients who were eligible but not vaccinated. Methods We conducted a retrospective analysis of electronic health record data at an urban academic ED from May to July 2021. The primary aim was to characterize the ED-vaccinated population, compared with ED patients who were eligible but unvaccinated and the physically adjacent outpatient vaccination clinic population. Results A total of 627 COVID-19 vaccinations were administered in the ED. Overall, 49% of ED patients during that time had already received at least one vaccine dose prior to ED arrival. Hispanic, non-Hispanic Black patients, and patients on non-commercial insurance had higher odds of being vaccinated in the ED as compared with outpatient clinic setting. Among eligible ED patients, men and patients who were uninsured/self-pay were more likely to accept ED vaccination. Conclusions This ED COVID-19 vaccination campaign demonstrated a higher likelihood to vaccinate individuals from racial/ethnic minority groups, those with high social vulnerability, and non-commercial insurance, when compared with a co-located outpatient vaccination clinic. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Clinical spectrum time course in non-Asian patients positive for anti-MDA5 antibodies

Author

Cavagna, Lorenzo, primary, Meloni, Federica, additional, Meyer, Alain, additional, Sambataro, Gianluca, additional, Belliato, Mirko, additional, De Langhe, Ellen, additional, Cavazzana, Ilaria, additional, Pipitone, Nicolò, additional, Triantafyllias, Konstantinos, additional, Mosca, Marta, additional, Barsotti, Simone, additional, Zampogna, Giuseppe, additional, Biglia, Alessandro, additional, Emmi, Giacomo, additional, De Visser, Marianne, additional, Van Der Kooi, Anneke, additional, Parronchi, Paola, additional, Hirschi, Sandrine, additional, da Silva, Jose Antonio Pereira, additional, Scirè, Carlo Alberto, additional, Furini, Federica, additional, Giannini, Margherita, additional, Martinez Gonzalez, Olga, additional, Damian, Laura, additional, Piette, Yves, additional, Smith, Vanessa, additional, Mera-Valera, Antonio, additional, Bachiller-Corral, Javier, additional, Cabezas Rodriguez, Ivan, additional, Brandy-Garcia, Anahy M., additional, Maurier, François, additional, Perrin, Julie, additional, Gonzalez-Moreno, Juan, additional, Drott, Ulrich, additional, Delbruck, Christiane, additional, Schwarting, Andreas, additional, Arrigoni, Eugenio, additional, Sebastiani, Gian Domenico, additional, Iuliano, Annamaria, additional, Nannini, Carlotta, additional, Quartuccio, Luca, additional, Rodriguez Cambron, Ana B., additional, Blázquez Cañamero, Maria Á., additional, Villa Blanco, Ignacio, additional, Cagnotto, Giovanni, additional, Pesci, Alberto, additional, Luppi, Francesco, additional, Dei, Giulia, additional, Romero Bueno, Fredeswinda Isabel, additional, Franceschini, Franco, additional, Chiapparoli, Ilaria, additional, Zanframundo, Giovanni, additional, Lettieri, Sara, additional, De Stefano, Ludovico, additional, Cutolo, Maurizio, additional, Mathieu, Alessandro, additional, Piga, Matteo, additional, Prieto-González, Sergio, additional, Moraes-Fontes, Maria Francisca, additional, Fonseca, Joao Eurico, additional, Jovani, Vega, additional, Riccieri, Valeria, additional, Santaniello, Alessandro, additional, Montfort, Stephen, additional, Bilocca, David, additional, Erre, Gian Luca, additional, Bartoloni, Elena, additional, Gerli, Roberto, additional, Monti, M. Cristina, additional, Lorenz, Hanns M., additional, Sambataro, Domenico, additional, Bellando Randone, Silvia, additional, Schneider, Udo, additional, Valenzuela, Claudia, additional, Lopez-Mejias, Raquel, additional, Cifrian, Jose, additional, Mejia, Mayra, additional, Gonzalez Perez, Monserrat-Ixchel, additional, Wendel, Sarah, additional, Fornaro, Marco, additional, De Luca, Giacomo, additional, Orsolini, Giovanni, additional, Rossini, Maurizio, additional, Dieude, Philippe, additional, Knitza, Johannes, additional, Castañeda, Santos, additional, Voll, Reinhard E., additional, Rojas-Serrano, Jorge, additional, Valentini, Adele, additional, Vancheri, Carlo, additional, Matucci-Cerinic, Marco, additional, Feist, Eugen, additional, Codullo, Veronica, additional, Iannone, Florenzo, additional, Distler, Jorg H., additional, Montecucco, Carlomaurizio, additional, and Gonzalez-Gay, Miguel A., additional

Published
2022
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18. Drive-Through Efficiency: How to Prepare for and Execute a Mass-Vaccination Event

Author

Resnick-Ault, Daniel, Wendel, Sarah K., Skaggs, Michael D., White, Sarah, and Zane, Richard D.

Subjects
Commentary
Abstract

Leaders at UCHealth emphasize that process design is the key to success for super sites to function smoothly, and they offer a playbook for how it’s done., Summary The 2019 novel coronavirus is on pace to overtake the 1918 influenza as the deadliest pandemic in U.S. history. A highly efficient strategy for vaccination is crucial to curbing the public health crisis. In January 2021, UCHealth — an innovative nonprofit health system serving Colorado, southern Wyoming, and western Nebraska — brought together key stakeholders to develop a new drive-through vaccination model with the goal of providing immunizations to 10,000 individuals over a 2-day period, which would be the largest vaccination effort in the United States at that time. Health care innovators, operational leaders, and information technology experts used iterative process improvement and real-time data collection to create the model. Their standards for efficiency in handling high-volume events are published in a playbook available to any entity hoping to utilize drive-through mass vaccination. From arrival to departure, median time spent in the vaccination clinic was 24 minutes, including 15 minutes of observation.

Published
2021

20. 'The future belongs to social entrepreneurs' : An exploratory study of Swedish social entrepreneurship

Author

Lang, Frans and Wendel, Sarah

Subjects
Social enterprise, International opportunities, Supporting institutions, Discovery, Exploitation, Social entrepreneurship, Business Administration, Företagsekonomi
Abstract

This thesis aims to examine the internationalization of Swedish social entrepreneurs, with the purpose to acquire a more profound understanding of how social entrepreneurial supporting institutions influence their discovery of international opportunities, as well as their exploitation of the identified opportunities. The study is conducted with qualitative methodology and was conducted by examining the concept of Swedish social entrepreneurship carried out in an international context.

Published
2020

21. Salary disparities based on gender in academic emergency medicine leadership.

Author

Wiler, Jennifer L., Wendel, Sarah K., Rounds, Kirsten, McGowan, Becky, and Baird, Janette

Subjects
HOSPITAL emergency services, CONFIDENCE intervals, LEADERSHIP, CROSS-sectional method, SEX distribution, WAGES, EMERGENCY medicine
Abstract

Objective: There are significantly fewer women than men in leadership roles in health care. Previous studies have shown that, overall, male physicians earn nearly $20,000 more annually than their female physician colleagues after adjusting for confounding factors. However, there has not been a description of physician leadership compensation in relation to gender. Methods: This was a successive cross‐sectional observation study design of 154 emergency departments in the United States from 5 years (2013, 2015–2018) using Association of Academic Chairs in Emergency Medicine and Academy of Administrators in Academic EM survey data. The primary variable of interest, leadership role, was attained by recoding the survey responses to assign primary job duty into four main categories: no leadership role, operations leadership, education leadership, and executive leadership. Results: Overall, 8820 responses were included. Across all survey years, the mean (±SD) percentage of women in any leadership role was significantly less than men (44.5% [95% CI: 42.8, 46.2%] vs. 55.3% [95% CI: 54.1, 56.5%]). Women in leadership roles worked more clinical hours than men in the same position (female median = 1008, male median = 960). Women also had significantly lower salaries than men at each of the 5‐year time points that data are reported, with unadjusted mean salary differences of –$54,409 per year for executives, –$27,803 for operational leaders, and –$17,803 for education leaders. Conclusions: Female physicians hold fewer leadership roles in academic emergency medicine (EM), and when they do, they work more clinical hours and are paid less than male physicians. As a specialty, EM should continue to investigate and report on gender achievement disparities as work is done to rectify the system inequalities. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Possible misclassification of cardiovascular risk by SCORE in antisynthetase syndrome: results of the pilot multicenter study RI.CAR.D.A

Author

Triantafyllias, Konstantinos, primary, Cavagna, Lorenzo, additional, Klonowski, Anna, additional, Drott, Ulrich, additional, Fiehn, Christoph, additional, Wendel, Sarah, additional, Bergner, Raoul, additional, de Blasi, Michele, additional, Voll, Reinhard E, additional, Baulmann, Johannes, additional, Konstantinides, Stavros, additional, Galle, Peter R, additional, and Schwarting, Andreas, additional

Published
2020
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23. Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

Author

Cavagna, Lorenzo, Trallero-Araguás, Ernesto, Meloni, Federica, Cavazzana, Ilaria, Rojas-Serrano, Jorge, Feist, Eugen, Zanframundo, Giovanni, Morandi, Valentina, Meyer, Alain, Pereira da Silva, Jose Antonio, Matos Costa, Carlo Jorge, Molberg, Oyvind, Andersson, Helena, Codullo, Veronica, Mosca, Marta, Barsotti, Simone, Neri, Rossella, Scirè, Carlo, Govoni, Marcello, Furini, Federica, Lopez-Longo, Francisco Javier, Martinez-Barrio, Julia, Schneider, Udo, Lorenz, Hanns-Martin, Doria, Andrea, Ghirardello, Anna, Ortego-Centeno, Norberto, Confalonieri, Marco, Tomietto, Paola, Pipitone, Nicolò, Rodriguez Cambron, Ana Belen, Blázquez Cañamero, María Ángeles, Voll, Reinhard Edmund, Wendel, Sarah, Scarpato, Salvatore, Maurier, Francois, Limonta, Massimiliano, Colombelli, Paolo, Giannini, Margherita, Geny, Bernard, Arrigoni, Eugenio, Bravi, Elena, Migliorini, Paola, Mathieu, Alessandro, Piga, Matteo, Drott, Ulrich, Delbrueck, Christiane, Bauhammer, Jutta, Cagnotto, Giovanni, Vancheri, Carlo, Sambataro, Gianluca, De Langhe, Ellen, Sainaghi, Pier Paolo, Monti, Cristina, Gigli Berzolari, Francesca, Romano, Mariaeva, Bonella, Francesco, Specker, Christof, Schwarting, Andreas, Villa Blanco, Ignacio, Selmi, Carlo, Ceribelli, Angela, Nuno, Laura, Mera-Varela, Antonio, Perez Gomez, Nair, Fusaro, Enrico, Parisi, Simone, Sinigaglia, Luigi, Del Papa, Nicoletta, Benucci, Maurizio, Cimmino, Marco Amedeo, Riccieri, Valeria, Conti, Fabrizio, Sebastiani, Gian Domenico, Iuliano, Annamaria, Emmi, Giacomo, Cammelli, Daniele, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Paolazzi, Giuseppe, Saketkoo, Lesley Ann, Giorgi, Roberto, Salaffi, Fausto, Cifrián, José Manuel, Caporali, Roberto, Locatelli, Francesco, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Pozzi, Maria Rosa, Claudia, Lomater, Distler, Jorg, Knitza, Johannes, Schett, George, Iannone, Florenzo, Fornaro, Marco, Franceschini, Franco, Quartuccio, Luca, Gerli, Roberto, Bartoloni, Elena, Bellando Randone, Silvia, Zampogna, Giuseppe, Gonzalez Perez, Montserrat I., Mejia, Mayra, Vicente, Esther, Triantafyllias, Konstantinos, Lopez-Mejias, Raquel, Matucci-Cerinic, Marco, Selva-O'Callaghan, Albert, Castañeda, Santos, Montecucco, Carlomaurizio, González-Gay, Miguel A., Universitat Autònoma de Barcelona, Universidad de Cantabria, Cavagna, L, Trallero-Araguás, E, Meloni, F, Cavazzana, I, Rojas-Serrano, J, Feist, E, Zanframundo, G, Morandi, V, Meyer, A, Pereira da Silva, J, Matos Costa, C, Molberg, O, Andersson, H, Codullo, V, Mosca, M, Barsotti, S, Neri, R, Scirè, C, Govoni, M, Furini, F, Lopez-Longo, F, Martinez-Barrio, J, Schneider, U, Lorenz, H, Doria, A, Ghirardello, A, Ortego-Centeno, N, Confalonieri, M, Tomietto, P, Pipitone, N, Rodriguez Cambron, A, Blázquez Cañamero, M, Voll, R, Wendel, S, Scarpato, S, Maurier, F, Limonta, M, Colombelli, P, Giannini, M, Geny, B, Arrigoni, E, Bravi, E, Migliorini, P, Mathieu, A, Piga, M, Drott, U, Delbrueck, C, Bauhammer, J, Cagnotto, G, Vancheri, C, Sambataro, G, De Langhe, E, Sainaghi, P, Monti, C, Gigli Berzolari, F, Romano, M, Bonella, F, Specker, C, Schwarting, A, Villa Blanco, I, Selmi, C, Ceribelli, A, Nuno, L, Mera-Varela, A, Perez Gomez, N, Fusaro, E, Parisi, S, Sinigaglia, L, Del Papa, N, Benucci, M, Cimmino, M, Riccieri, V, Conti, F, Sebastiani, G, Iuliano, A, Emmi, G, Cammelli, D, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Paolazzi, G, Saketkoo, L, Giorgi, R, Salaffi, F, Cifrian, J, Caporali, R, Locatelli, F, Marchioni, E, Pesci, A, Dei, G, Pozzi, M, Claudia, L, Distler, J, Knitza, J, Schett, G, Iannone, F, Fornaro, M, Franceschini, F, Quartuccio, L, Gerli, R, Bartoloni, E, Bellando Randone, S, Zampogna, G, Gonzalez Perez, M, Mejia, M, Vicente, E, Triantafyllias, K, Lopez-Mejias, R, Matucci-Cerinic, M, Selva-O'Callaghan, A, Castañeda, S, Montecucco, C, and Gonzalez-Gay, M

Subjects
medicine.medical_specialty, antisynthetase antibodies, antisynthetase syndrome, arthritis, interstitial lung disease, myositis, Medizin, Arthritis, lcsh:Medicine, Antisynthetase syndrome, Interstitial lung disease, Article, NO, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, antisynthetase antibodies, antisynthetase syndrome, arthritis, interstitial lung disease, myositis, ddc:610, Myositis, 030203 arthritis & rheumatology, Antisynthetase antibodies, biology, business.industry, lcsh:R, Autoantibody, General Medicine, medicine.disease, arthriti, 030228 respiratory system, Time course, Cohort, biology.protein, Antibody, business, antisynthetase antibodie
Abstract

Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group's cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The "ex-novo" occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies' positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition. ispartof: JOURNAL OF CLINICAL MEDICINE vol:8 issue:11 ispartof: location:Switzerland status: published

Published
2019

24. Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

Author

Cavagna, L, Trallero-Araguás, E, Meloni, F, Cavazzana, I, Rojas-Serrano, J, Feist, E, Zanframundo, G, Morandi, V, Meyer, A, Pereira da Silva, J, Matos Costa, C, Molberg, O, Andersson, H, Codullo, V, Mosca, M, Barsotti, S, Neri, R, Scirè, C, Govoni, M, Furini, F, Lopez-Longo, F, Martinez-Barrio, J, Schneider, U, Lorenz, H, Doria, A, Ghirardello, A, Ortego-Centeno, N, Confalonieri, M, Tomietto, P, Pipitone, N, Rodriguez Cambron, A, Blázquez Cañamero, M, Voll, R, Wendel, S, Scarpato, S, Maurier, F, Limonta, M, Colombelli, P, Giannini, M, Geny, B, Arrigoni, E, Bravi, E, Migliorini, P, Mathieu, A, Piga, M, Drott, U, Delbrueck, C, Bauhammer, J, Cagnotto, G, Vancheri, C, Sambataro, G, De Langhe, E, Sainaghi, P, Monti, C, Gigli Berzolari, F, Romano, M, Bonella, F, Specker, C, Schwarting, A, Villa Blanco, I, Selmi, C, Ceribelli, A, Nuno, L, Mera-Varela, A, Perez Gomez, N, Fusaro, E, Parisi, S, Sinigaglia, L, Del Papa, N, Benucci, M, Cimmino, M, Riccieri, V, Conti, F, Sebastiani, G, Iuliano, A, Emmi, G, Cammelli, D, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Paolazzi, G, Saketkoo, L, Giorgi, R, Salaffi, F, Cifrian, J, Caporali, R, Locatelli, F, Marchioni, E, Pesci, A, Dei, G, Pozzi, M, Claudia, L, Distler, J, Knitza, J, Schett, G, Iannone, F, Fornaro, M, Franceschini, F, Quartuccio, L, Gerli, R, Bartoloni, E, Bellando Randone, S, Zampogna, G, Gonzalez Perez, M, Mejia, M, Vicente, E, Triantafyllias, K, Lopez-Mejias, R, Matucci-Cerinic, M, Selva-O'Callaghan, A, Castañeda, S, Montecucco, C, Gonzalez-Gay, M, Cavagna, Lorenzo, Trallero-Araguás, Ernesto, Meloni, Federica, Cavazzana, Ilaria, Rojas-Serrano, Jorge, Feist, Eugen, Zanframundo, Giovanni, Morandi, Valentina, Meyer, Alain, Pereira da Silva, Jose Antonio, Matos Costa, Carlo Jorge, Molberg, Oyvind, Andersson, Helena, Codullo, Veronica, Mosca, Marta, Barsotti, Simone, Neri, Rossella, Scirè, Carlo, Govoni, Marcello, Furini, Federica, Lopez-Longo, Francisco Javier, Martinez-Barrio, Julia, Schneider, Udo, Lorenz, Hanns-Martin, Doria, Andrea, Ghirardello, Anna, Ortego-Centeno, Norberto, Confalonieri, Marco, Tomietto, Paola, Pipitone, Nicolò, Rodriguez Cambron, Ana Belen, Blázquez Cañamero, María Ángeles, Voll, Reinhard Edmund, Wendel, Sarah, Scarpato, Salvatore, Maurier, Francois, Limonta, Massimiliano, Colombelli, Paolo, Giannini, Margherita, Geny, Bernard, Arrigoni, Eugenio, Bravi, Elena, Migliorini, Paola, Mathieu, Alessandro, Piga, Matteo, Drott, Ulrich, Delbrueck, Christiane, Bauhammer, Jutta, Cagnotto, Giovanni, Vancheri, Carlo, Sambataro, Gianluca, De Langhe, Ellen, Sainaghi, Pier Paolo, Monti, Cristina, Gigli Berzolari, Francesca, Romano, Mariaeva, Bonella, Francesco, Specker, Christof, Schwarting, Andreas, Villa Blanco, Ignacio, Selmi, Carlo, Ceribelli, Angela, Nuno, Laura, Mera-Varela, Antonio, Perez Gomez, Nair, Fusaro, Enrico, Parisi, Simone, Sinigaglia, Luigi, Del Papa, Nicoletta, Benucci, Maurizio, Cimmino, Marco Amedeo, Riccieri, Valeria, Conti, Fabrizio, Sebastiani, Gian Domenico, Iuliano, Annamaria, Emmi, Giacomo, Cammelli, Daniele, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Paolazzi, Giuseppe, Saketkoo, Lesley Ann, Giorgi, Roberto, Salaffi, Fausto, Cifrian, Jose, Caporali, Roberto, Locatelli, Francesco, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Pozzi, Maria Rosa, Claudia, Lomater, Distler, Jorg, Knitza, Johannes, Schett, George, Iannone, Florenzo, Fornaro, Marco, Franceschini, Franco, Quartuccio, Luca, Gerli, Roberto, Bartoloni, Elena, Bellando Randone, Silvia, Zampogna, Giuseppe, Gonzalez Perez, Montserrat I, Mejia, Mayra, Vicente, Esther, Triantafyllias, Konstantinos, Lopez-Mejias, Raquel, Matucci-Cerinic, Marco, Selva-O'Callaghan, Albert, Castañeda, Santos, Montecucco, Carlomaurizio, Gonzalez-Gay, Miguel Angel, Cavagna, L, Trallero-Araguás, E, Meloni, F, Cavazzana, I, Rojas-Serrano, J, Feist, E, Zanframundo, G, Morandi, V, Meyer, A, Pereira da Silva, J, Matos Costa, C, Molberg, O, Andersson, H, Codullo, V, Mosca, M, Barsotti, S, Neri, R, Scirè, C, Govoni, M, Furini, F, Lopez-Longo, F, Martinez-Barrio, J, Schneider, U, Lorenz, H, Doria, A, Ghirardello, A, Ortego-Centeno, N, Confalonieri, M, Tomietto, P, Pipitone, N, Rodriguez Cambron, A, Blázquez Cañamero, M, Voll, R, Wendel, S, Scarpato, S, Maurier, F, Limonta, M, Colombelli, P, Giannini, M, Geny, B, Arrigoni, E, Bravi, E, Migliorini, P, Mathieu, A, Piga, M, Drott, U, Delbrueck, C, Bauhammer, J, Cagnotto, G, Vancheri, C, Sambataro, G, De Langhe, E, Sainaghi, P, Monti, C, Gigli Berzolari, F, Romano, M, Bonella, F, Specker, C, Schwarting, A, Villa Blanco, I, Selmi, C, Ceribelli, A, Nuno, L, Mera-Varela, A, Perez Gomez, N, Fusaro, E, Parisi, S, Sinigaglia, L, Del Papa, N, Benucci, M, Cimmino, M, Riccieri, V, Conti, F, Sebastiani, G, Iuliano, A, Emmi, G, Cammelli, D, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Paolazzi, G, Saketkoo, L, Giorgi, R, Salaffi, F, Cifrian, J, Caporali, R, Locatelli, F, Marchioni, E, Pesci, A, Dei, G, Pozzi, M, Claudia, L, Distler, J, Knitza, J, Schett, G, Iannone, F, Fornaro, M, Franceschini, F, Quartuccio, L, Gerli, R, Bartoloni, E, Bellando Randone, S, Zampogna, G, Gonzalez Perez, M, Mejia, M, Vicente, E, Triantafyllias, K, Lopez-Mejias, R, Matucci-Cerinic, M, Selva-O'Callaghan, A, Castañeda, S, Montecucco, C, Gonzalez-Gay, M, Cavagna, Lorenzo, Trallero-Araguás, Ernesto, Meloni, Federica, Cavazzana, Ilaria, Rojas-Serrano, Jorge, Feist, Eugen, Zanframundo, Giovanni, Morandi, Valentina, Meyer, Alain, Pereira da Silva, Jose Antonio, Matos Costa, Carlo Jorge, Molberg, Oyvind, Andersson, Helena, Codullo, Veronica, Mosca, Marta, Barsotti, Simone, Neri, Rossella, Scirè, Carlo, Govoni, Marcello, Furini, Federica, Lopez-Longo, Francisco Javier, Martinez-Barrio, Julia, Schneider, Udo, Lorenz, Hanns-Martin, Doria, Andrea, Ghirardello, Anna, Ortego-Centeno, Norberto, Confalonieri, Marco, Tomietto, Paola, Pipitone, Nicolò, Rodriguez Cambron, Ana Belen, Blázquez Cañamero, María Ángeles, Voll, Reinhard Edmund, Wendel, Sarah, Scarpato, Salvatore, Maurier, Francois, Limonta, Massimiliano, Colombelli, Paolo, Giannini, Margherita, Geny, Bernard, Arrigoni, Eugenio, Bravi, Elena, Migliorini, Paola, Mathieu, Alessandro, Piga, Matteo, Drott, Ulrich, Delbrueck, Christiane, Bauhammer, Jutta, Cagnotto, Giovanni, Vancheri, Carlo, Sambataro, Gianluca, De Langhe, Ellen, Sainaghi, Pier Paolo, Monti, Cristina, Gigli Berzolari, Francesca, Romano, Mariaeva, Bonella, Francesco, Specker, Christof, Schwarting, Andreas, Villa Blanco, Ignacio, Selmi, Carlo, Ceribelli, Angela, Nuno, Laura, Mera-Varela, Antonio, Perez Gomez, Nair, Fusaro, Enrico, Parisi, Simone, Sinigaglia, Luigi, Del Papa, Nicoletta, Benucci, Maurizio, Cimmino, Marco Amedeo, Riccieri, Valeria, Conti, Fabrizio, Sebastiani, Gian Domenico, Iuliano, Annamaria, Emmi, Giacomo, Cammelli, Daniele, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Paolazzi, Giuseppe, Saketkoo, Lesley Ann, Giorgi, Roberto, Salaffi, Fausto, Cifrian, Jose, Caporali, Roberto, Locatelli, Francesco, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Pozzi, Maria Rosa, Claudia, Lomater, Distler, Jorg, Knitza, Johannes, Schett, George, Iannone, Florenzo, Fornaro, Marco, Franceschini, Franco, Quartuccio, Luca, Gerli, Roberto, Bartoloni, Elena, Bellando Randone, Silvia, Zampogna, Giuseppe, Gonzalez Perez, Montserrat I, Mejia, Mayra, Vicente, Esther, Triantafyllias, Konstantinos, Lopez-Mejias, Raquel, Matucci-Cerinic, Marco, Selva-O'Callaghan, Albert, Castañeda, Santos, Montecucco, Carlomaurizio, and Gonzalez-Gay, Miguel Angel

Abstract

Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group's cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The "ex-novo" occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies' positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.

Published
2019

25. Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

Author

Cavagna, Lorenzo, primary, Trallero-Araguás, Ernesto, additional, Meloni, Federica, additional, Cavazzana, Ilaria, additional, Rojas-Serrano, Jorge, additional, Feist, Eugen, additional, Zanframundo, Giovanni, additional, Morandi, Valentina, additional, Meyer, Alain, additional, Pereira da Silva, Jose, additional, Matos Costa, Carlo, additional, Molberg, Oyvind, additional, Andersson, Helena, additional, Codullo, Veronica, additional, Mosca, Marta, additional, Barsotti, Simone, additional, Neri, Rossella, additional, Scirè, Carlo, additional, Govoni, Marcello, additional, Furini, Federica, additional, Lopez-Longo, Francisco, additional, Martinez-Barrio, Julia, additional, Schneider, Udo, additional, Lorenz, Hanns-Martin, additional, Doria, Andrea, additional, Ghirardello, Anna, additional, Ortego-Centeno, Norberto, additional, Confalonieri, Marco, additional, Tomietto, Paola, additional, Pipitone, Nicolò, additional, Rodriguez Cambron, Ana, additional, Blázquez Cañamero, María, additional, Voll, Reinhard, additional, Wendel, Sarah, additional, Scarpato, Salvatore, additional, Maurier, Francois, additional, Limonta, Massimiliano, additional, Colombelli, Paolo, additional, Giannini, Margherita, additional, Geny, Bernard, additional, Arrigoni, Eugenio, additional, Bravi, Elena, additional, Migliorini, Paola, additional, Mathieu, Alessandro, additional, Piga, Matteo, additional, Drott, Ulrich, additional, Delbrueck, Christiane, additional, Bauhammer, Jutta, additional, Cagnotto, Giovanni, additional, Vancheri, Carlo, additional, Sambataro, Gianluca, additional, De Langhe, Ellen, additional, Sainaghi, Pier, additional, Monti, Cristina, additional, Gigli Berzolari, Francesca, additional, Romano, Mariaeva, additional, Bonella, Francesco, additional, Specker, Christof, additional, Schwarting, Andreas, additional, Villa Blanco, Ignacio, additional, Selmi, Carlo, additional, Ceribelli, Angela, additional, Nuno, Laura, additional, Mera-Varela, Antonio, additional, Perez Gomez, Nair, additional, Fusaro, Enrico, additional, Parisi, Simone, additional, Sinigaglia, Luigi, additional, Del Papa, Nicoletta, additional, Benucci, Maurizio, additional, Cimmino, Marco, additional, Riccieri, Valeria, additional, Conti, Fabrizio, additional, Sebastiani, Gian, additional, Iuliano, Annamaria, additional, Emmi, Giacomo, additional, Cammelli, Daniele, additional, Sebastiani, Marco, additional, Manfredi, Andreina, additional, Bachiller-Corral, Javier, additional, Sifuentes Giraldo, Walter, additional, Paolazzi, Giuseppe, additional, Saketkoo, Lesley, additional, Giorgi, Roberto, additional, Salaffi, Fausto, additional, Cifrian, Jose, additional, Caporali, Roberto, additional, Locatelli, Francesco, additional, Marchioni, Enrico, additional, Pesci, Alberto, additional, Dei, Giulia, additional, Pozzi, Maria, additional, Claudia, Lomater, additional, Distler, Jorg, additional, Knitza, Johannes, additional, Schett, George, additional, Iannone, Florenzo, additional, Fornaro, Marco, additional, Franceschini, Franco, additional, Quartuccio, Luca, additional, Gerli, Roberto, additional, Bartoloni, Elena, additional, Bellando Randone, Silvia, additional, Zampogna, Giuseppe, additional, Gonzalez Perez, Montserrat, additional, Mejia, Mayra, additional, Vicente, Esther, additional, Triantafyllias, Konstantinos, additional, Lopez-Mejias, Raquel, additional, Matucci-Cerinic, Marco, additional, Selva-O’Callaghan, Albert, additional, Castañeda, Santos, additional, Montecucco, Carlomaurizio, additional, and Gonzalez-Gay, Miguel, additional

Published
2019
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27. Possible misclassification of cardiovascular risk by SCORE in antisynthetase syndrome: results of the pilot multicenter study RI.CAR.D.A.

Author

Triantafyllias, Konstantinos, Cavagna, Lorenzo, Klonowski, Anna, Drott, Ulrich, Fiehn, Christoph, Wendel, Sarah, Bergner, Raoul, Blasi, Michele de, Voll, Reinhard E, Baulmann, Johannes, Konstantinides, Stavros, Galle, Peter R, and Schwarting, Andreas

Subjects
CARDIOVASCULAR diseases risk factors, BIOMARKERS, PILOT projects, RESEARCH, CAROTID artery, CAROTID intima-media thickness, ANTISYNTHETASE syndrome, MEDICAL cooperation, CASE-control method, RISK assessment, DOPPLER ultrasonography, DESCRIPTIVE statistics
Abstract

Objectives To test the ability of an established traditional cardiovascular (CV) risk prediction score [Systematic COronary Risk Evaluation (SCORE)] and its EULAR modified version (mSCORE) to identify antisynthetase syndrome (ASyS) patients at high CV risk and to examine for the first time associations of CV and cerebrovascular surrogate markers with clinical and immunological ASyS parameters. Methods SCORE/mSCORE and the gold standard marker of aortic stiffness [carotid-femoral pulse wave velocity (cfPWV)] were examined in ASyS patients and healthy controls. Moreover, sonography of the common- (CCA) and internal- (ICA) carotid arteries was performed in subsets of both groups, evaluating carotid intima-media thickness (cIMT), plaques and Doppler sonographic cerebrovascular surrogates [resistance (RI) and pulsatility (PI) indices]. Results We recruited 66 ASyS patients and 88 controls. According to mSCORE, 10% of the patients had high CV risk. However, cfPWV and carotid sonography revealed an increased CV risk in 21.2% and subclinical carotid atherosclerosis (SCA) in 85.7% of the patients, respectively. cfPWV and cIMT were higher in patients compared with controls (P adj=0.021 and P adj=0.003, respectively). In the ASyS group, cfPWV and cIMT correlated significantly with age (r  = 0.679; P <0.001 and r  = 0.664; P <0.001, respectively). Moreover, cfPWV correlated with BMI (P adj=0.001) and diabetes (P adj=0.043). CCA-RI and CCA-PI showed significant associations with creatine phosphokinase (r  = 0.629; P =0.012 and r  = 0.574; P =0.032, respectively) and ICA-RI and ICA-PI were higher in patients with lung involvement (both; P =0.039). Conclusion ASyS patients had higher aortic stiffness and SCA compared with controls, even after adjustment for confounders. SCORE/mSCORE performed poorly in identifying high-risk patients compared with cfPWV and carotid sonography. Thus, cfPWV and carotid sonography may improve CV and cerebrovascular screening in ASyS. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Maternal Syphilis: Variations in Prenatal Screening, Treatment, and Diagnosis of Congenital Syphilis

Author

Mani, Sriniwasan B., Pegany, Roma, Sheng, Dana, Wendel, Sarah K., and Gaydos, Charlotte

Subjects
Communicable diseases in pregnancy, Syphilis, Congenital, hereditary, and infantile, Prenatal diagnosis, Medicine, Syphilis--Diagnosis
Abstract

Syphilis is a sexually transmitted infection that, if left untreated, can impact fetal development. In this systematic review of syphilis in pregnancy, we attempt to better understand worldwide discrepancies regarding its diagnosis and management. OVID MEDLINE and PubMed databases were searched for keywords and 74 relevant articles were identified. Twenty-nine articles were ultimately included in our review. In the literature spanning from 1944—2014, we identified several variations in maternal syphilis screening and treatment, as well as a spectrum of gestational outcomes. Even following the publication of universal guidelines by the World Health Organization, the Centers for Disease Control and Prevention, and scientific investigators, practice patterns have continued to vary. Greater adherence to these guidelines could improve the quality of research in this area and promote earlier detection and thus prevention of maternal and congenital syphilis.

Published
2017
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30. Albendazole Treatment Improves Work Capacity in Women Smallholder Farmers Infected with Hookworm: A Double-Blind Randomized Control Trial

Author

Salmon, Margaret, primary, Salmon, Christian, additional, Masoda, Maurice, additional, Salumu, Jean-Maurice, additional, Bozzi, Carmine, additional, Nieburg, Phil, additional, Harrison, Lisa M., additional, Humphries, Debbie, additional, Abaca Uvon, Naomi, additional, Wendel, Sarah K., additional, Trout, Clint, additional, and Cappello, Michael, additional

Published
2018
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35. Mass distribution of albendazole for hookworm control in women smallholder famers, Democratic Republic of Congo: a double blind randomised controlled trial

Author

Masoda, Maurice, primary, Salmon, Margaret, additional, Salmon, Christian, additional, Salumu, Jean Maurice, additional, Bozzi, Carmine, additional, Zaidi, Rene, additional, Harrison, Lisa Marie, additional, Humphries, Debbie, additional, Trout, Clinton, additional, Uvon, Naomi Awaca, additional, Wendel, Sarah K, additional, and Cappello, Michael, additional

Published
2016
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38. Failure to Identify HIV-Infected Individuals in a Clinical Trial Using a Single HIV Rapid Test for Screening

Author

Piwowar-Manning, Estelle, primary, Fogel, Jessica M., additional, Laeyendecker, Oliver, additional, Wolf, Shauna, additional, Cummings, Vanessa, additional, Marzinke, Mark A., additional, Clarke, William, additional, Breaud, Autumn, additional, Wendel, Sarah, additional, Wang, Lei, additional, Swanson, Priscilla, additional, Hackett, John, additional, Mannheimer, Sharon, additional, del Rio, Carlos, additional, Kuo, Irene, additional, Harawa, Nina T., additional, Koblin, Beryl A., additional, Moore, Richard, additional, Blankson, Joel N., additional, and Eshleman, Susan H., additional

Published
2014
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39. Limited HIV-1 Superinfection in Seroconverters from the CAPRISA 004 Microbicide Trial

Author

Redd, Andrew D., primary, Mullis, Caroline E., additional, Wendel, Sarah K., additional, Sheward, Daniel, additional, Martens, Craig, additional, Bruno, Daniel, additional, Werner, Lise, additional, Garrett, Nigel J., additional, Abdool Karim, Quarraisha, additional, Williamson, Carolyn, additional, Porcella, Stephen F., additional, Quinn, Thomas C., additional, and Abdool Karim, Salim S., additional

Published
2014
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41. Liver Stiffness Is Associated With Monocyte Activation in HIV-Infected Ugandans Without Viral Hepatitis

Author

Redd, Andrew D., primary, Wendel, Sarah K., additional, Grabowski, Mary K., additional, Ocama, Ponsiano, additional, Kiggundu, Valerian, additional, Bbosa, Francis, additional, Boaz, Iga, additional, Balagopal, Ashwin, additional, Reynolds, Steven J., additional, Gray, Ronald H., additional, Serwadda, David, additional, Kirk, Gregory D., additional, Quinn, Thomas C., additional, and Stabinski, Lara, additional

Published
2013
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43. Clinical spectrum time course in non-Asian patients positive for anti-MDA5 antibodies

Author

Lorenzo, Cavagna, Federica, Meloni, Alain, Meyer, Gianluca, Sambataro, Mirko, Belliato, Ellen De Langhe, Cavazzana, Ilaria, Nicolò, Pipitone, Konstantinos, Triantafyllias, Marta, Mosca, Simone, Barsotti, Giuseppe, Zampogna, Alessandro, Biglia, Giacomo, Emmi, Marianne De Visser, Anneke Van Der Kooi, Paola, Parronchi, Sandrine, Hirschi, Jose Antonio Pereira da Silva, Carlo Alberto Scirè, Federica, Furini, Margherita, Giannini, Olga Martinez Gonzalez, Laura, Damian, Yves, Piette, Vanessa, Smith, Antonio, Mera-Valera, Javier, Bachiller-Corral, Ivan Cabezas Rodriguez, Anahy, M Brandy-Garcia, François, Maurier, Julie, Perrin, Juan, Gonzalez-Moreno, Ulrich, Drott, Christiane, Delbruck, Andreas, Schwarting, Eugenio, Arrigoni, Gian Domenico Sebastiani, Annamaria, Iuliano, Carlotta, Nannini, Luca, Quartuccio, Ana, B Rodriguez Cambron, Maria, Á Blázquez Cañamero, Ignacio Villa Blanco, Giovanni, Cagnotto, Alberto, Pesci, Francesco, Luppi, Giulia, Dei, Fredeswinda Isabel Romero Bueno, Franceschini, Franco, Ilaria, Chiapparoli, Giovanni, Zanframundo, Sara, Lettieri, Ludovico De Stefano, Maurizio, Cutolo, Alessandro, Mathieu, Matteo, Piga, Sergio, Prieto-González, Maria Francisca Moraes-Fontes, Joao Eurico Fonseca, Vega, Jovani, Valeria, Riccieri, Alessandro, Santaniello, Stephen, Montfort, David, Bilocca, Gian Luca Erre, Elena, Bartoloni, Roberto, Gerli, M Cristina Monti, Hanns, M Lorenz, Domenico, Sambataro, Silvia Bellando Randone, Udo, Schneider, Claudia, Valenzuela, Raquel, Lopez-Mejias, Jose, Cifrian, Mayra, Mejia, Monserrat-Ixchel Gonzalez Perez, Sarah, Wendel, Marco, Fornaro, Giacomo De Luca, Giovanni, Orsolini, Maurizio, Rossini, Philippe, Dieude, Johannes, Knitza, Santos, Castañeda, Reinhard, E Voll, Jorge, Rojas-Serrano, Adele, Valentini, Carlo, Vancheri, Marco, Matucci-Cerinic, Eugen, Feist, Veronica, Codullo, Florenzo, Iannone, Jorg, H Distler, Carlomaurizio, Montecucco, Miguel, A Gonzalez-Gay, AENEAS collaborative group, Neurology, ANS - Neuroinfection & -inflammation, AII - Inflammatory diseases, EURO-NMD, Cavagna, L, Meloni, F, Meyer, A, Sambataro, G, Belliato, M, De Langhe, E, Cavazzana, I, Pipitone, N, Triantafyllias, K, Mosca, M, Barsotti, S, Zampogna, G, Biglia, A, Emmi, G, De Visser, M, Van Der Kooi, A, Parronchi, P, Hirschi, S, da Silva, J, Scire, C, Furini, F, Giannini, M, Martinez Gonzalez, O, Damian, L, Piette, Y, Smith, V, Mera-Valera, A, Bachiller-Corral, J, Cabezas Rodriguez, I, Brandy-Garcia, A, Maurier, F, Perrin, J, Gonzalez-Moreno, J, Drott, U, Delbruck, C, Schwarting, A, Arrigoni, E, Sebastiani, G, Iuliano, A, Nannini, C, Quartuccio, L, Rodriguez Cambron, A, Blazquez Canamero, M, Villa Blanco, I, Cagnotto, G, Pesci, A, Luppi, F, Dei, G, Romero Bueno, F, Franceschini, F, Chiapparoli, I, Zanframundo, G, Lettieri, S, De Stefano, L, Cutolo, M, Mathieu, A, Piga, M, Prieto-Gonzalez, S, Moraes-Fontes, M, Fonseca, J, Jovani, V, Riccieri, V, Santaniello, A, Montfort, S, Bilocca, D, Erre, G, Bartoloni, E, Gerli, R, Monti, M, Lorenz, H, Sambataro, D, Bellando Randone, S, Schneider, U, Valenzuela, C, Lopez-Mejias, R, Cifrian, J, Mejia, M, Gonzalez Perez, M, Wendel, S, Fornaro, M, De Luca, G, Orsolini, G, Rossini, M, Dieude, P, Knitza, J, Castaneda, S, Voll, R, Rojas-Serrano, J, Valentini, A, Vancheri, C, Matucci-Cerinic, M, Feist, E, Codullo, V, Iannone, F, Distler, J, Montecucco, C, Gonzalez-Gay, M, Repositório da Universidade de Lisboa, Cavagna, Lorenzo, Meloni, Federica, Meyer, Alain, Sambataro, Gianluca, Belliato, Mirko, De Langhe, Ellen, Cavazzana, Ilaria, Pipitone, Nicolò, Triantafyllias, Konstantino, Mosca, Marta, Barsotti, Simone, Zampogna, Giuseppe, Biglia, Alessandro, Emmi, Giacomo, De Visser, Marianne, Van Der Kooi, Anneke, Parronchi, Paola, Hirschi, Sandrine, da Silva, Jose Antonio Pereira, Scirè, Carlo Alberto, Furini, Federica, Giannini, Margherita, Martinez Gonzalez, Olga, Damian, Laura, Piette, Yve, Smith, Vanessa, Mera-Valera, Antonio, Bachiller-Corral, Javier, Cabezas Rodriguez, Ivan, Brandy-Garcia, Anahy M, Maurier, Françoi, Perrin, Julie, Gonzalez-Moreno, Juan, Drott, Ulrich, Delbruck, Christiane, Schwarting, Andrea, Arrigoni, Eugenio, Sebastiani, Gian Domenico, Iuliano, Annamaria, Nannini, Carlotta, Quartuccio, Luca, Rodriguez Cambron, Ana B, Blázquez Cañamero, Maria Á, Villa Blanco, Ignacio, Cagnotto, Giovanni, Pesci, Alberto, Luppi, Francesco, Dei, Giulia, Romero Bueno, Fredeswinda Isabel, Franceschini, Franco, Chiapparoli, Ilaria, Zanframundo, Giovanni, Lettieri, Sara, De Stefano, Ludovico, Cutolo, Maurizio, Mathieu, Alessandro, Piga, Matteo, Prieto-González, Sergio, Moraes-Fontes, Maria Francisca, Fonseca, Joao Eurico, Jovani, Vega, Riccieri, Valeria, Santaniello, Alessandro, Montfort, Stephen, Bilocca, David, Erre, Gian Luca, Bartoloni, Elena, Gerli, Roberto, Monti, M Cristina, Lorenz, Hanns M, Sambataro, Domenico, Bellando Randone, Silvia, Schneider, Udo, Valenzuela, Claudia, Lopez-Mejias, Raquel, Cifrian, Jose, Mejia, Mayra, Gonzalez Perez, Monserrat-Ixchel, Wendel, Sarah, Fornaro, Marco, De Luca, Giacomo, Orsolini, Giovanni, Rossini, Maurizio, Dieude, Philippe, Knitza, Johanne, Castañeda, Santo, Voll, Reinhard E, Rojas-Serrano, Jorge, Valentini, Adele, Vancheri, Carlo, Matucci-Cerinic, Marco, Feist, Eugen, Codullo, Veronica, Iannone, Florenzo, Distler, Jorg H, Montecucco, Carlomaurizio, and Gonzalez-Gay, Miguel A

Subjects
Lung Diseases, Interferon-Induced Helicase, IFIH1, rapidly progressive interstitial lung diseases, idiopathic inflammatory myopathies, idiopathic inflammatory myopathie, Immunology, Middle Aged, Prognosis, Dermatomyositis, rapidly progressive interstitial lung disease, Rheumatology, melanoma differentiation-associated protein 5 antibody, rapidly progressive interstitial lung diseases, idiopathic inflammatory myopathies, Humans, Immunology and Allergy, Female, Lung Diseases, Interstitial, Interferon-Induced Helicase, Interstitial, melanoma differentiation-associated protein 5 antibody, Autoantibodies, Retrospective Studies, IFIH1
Abstract

© Copyright Clinical and Experimental Rheumatology 2022., Objectives: To define the clinical spectrum time-course and prognosis of non-Asian patients positive for anti-MDA5 antibodies. Methods: We conducted a multicentre, international, retrospective cohort study. Results: 149 anti-MDA5 positive patients (median onset age 53 years, median disease duration 18 months), mainly females (100, 67%), were included. Dermatomyositis (64, 43%) and amyopathic dermatomyositis (47, 31%), were the main diagnosis; 15 patients (10%) were classified as interstitial pneumonia with autoimmune features (IPAF) and 7 (5%) as rheumatoid arthritis. The main clinical findings observed were myositis (84, 56%), interstitial lung disease (ILD) (108, 78%), skin lesions (111, 74%), and arthritis (76, 51%). The onset of these manifestations was not concomitant in 74 cases (50%). Of note, 32 (21.5%) patients were admitted to the intensive care unit for rapidly progressive-ILD, which occurred in median 2 months from lung involvement detection, in the majority of cases (28, 19%) despite previous immunosuppressive treatment. One-third of patients (47, 32% each) was ANA and anti-ENA antibodies negative and a similar percentage was anti-Ro52 kDa antibodies positive. Non-specific interstitial pneumonia (65, 60%), organising pneumonia (23, 21%), and usual interstitial pneumonia-like pattern (14, 13%) were the main ILD patterns observed. Twenty-six patients died (17%), 19 (13%) had a rapidly progressive-ILD. Conclusions: The clinical spectrum of the anti-MDA5 antibodies-related disease is heterogeneous. Rapidly-progressive ILD deeply impacts the prognosis also in non-Asian patients, occurring early during the disease course. Anti-MDA5 antibody positivity should be considered even when baseline autoimmune screening is negative, anti-Ro52 kDa antibodies are positive, and radiology findings show a NSIP pattern.

Published
2022

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