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1. Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

Author

Aznaourova, Marina, Schmerer, Nils, Janga, Harshavardhan, Zhang, Zhenhua, Pauck, Kim, Bushe, Judith, Volkers, Sarah M., Wendisch, Daniel, Georg, Philipp, Ntini, Evgenia, Aillaud, Michelle, Gündisch, Margrit, Mack, Elisabeth, Skevaki, Chrysanthi, Keller, Christian, Bauer, Christian, Bertrams, Wilhelm, Marsico, Annalisa, Nist, Andrea, Stiewe, Thorsten, Gruber, Achim D., Ruppert, Clemens, Li, Yang, Garn, Holger, Sander, Leif E., Schmeck, Bernd, and Schulte, Leon N.

Published
2022

2. Monkeypox in-patients with severe anal pain

Author

Pfäfflin, Frieder, Wendisch, Daniel, Scherer, Roland, Jürgens, Linda, Godzick-Njomgang, Gisèle, Tranter, Eva, Tober-Lau, Pinkus, Stegemann, Miriam Songa, Corman, Victor Max, Kurth, Florian, and Schürmann, Dirk

Published
2023
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3. SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

Author

Wendisch, Daniel, Dietrich, Oliver, Mari, Tommaso, von Stillfried, Saskia, Ibarra, Ignacio L., Mittermaier, Mirja, Mache, Christin, Chua, Robert Lorenz, Knoll, Rainer, Timm, Sara, Brumhard, Sophia, Krammer, Tobias, Zauber, Henrik, Hiller, Anna Luisa, Pascual-Reguant, Anna, Mothes, Ronja, Bülow, Roman David, Schulze, Jessica, Leipold, Alexander M., Djudjaj, Sonja, Erhard, Florian, Geffers, Robert, Pott, Fabian, Kazmierski, Julia, Radke, Josefine, Pergantis, Panagiotis, Baßler, Kevin, Conrad, Claudia, Aschenbrenner, Anna C., Sawitzki, Birgit, Landthaler, Markus, Wyler, Emanuel, Horst, David, Hippenstiel, Stefan, Hocke, Andreas, Heppner, Frank L., Uhrig, Alexander, Garcia, Carmen, Machleidt, Felix, Herold, Susanne, Elezkurtaj, Sefer, Thibeault, Charlotte, Witzenrath, Martin, Cochain, Clément, Suttorp, Norbert, Drosten, Christian, Goffinet, Christine, Kurth, Florian, Schultze, Joachim L., Radbruch, Helena, Ochs, Matthias, Eils, Roland, Müller-Redetzky, Holger, Hauser, Anja E., Luecken, Malte D., Theis, Fabian J., Conrad, Christian, Wolff, Thorsten, Boor, Peter, Selbach, Matthias, Saliba, Antoine-Emmanuel, and Sander, Leif Erik

Published
2021
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4. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

Author

Al-Rim, Ben, Bardtke, Lara, Beheim-Schwarzbach, Jörn Ilmo, Behn, Kerstin, Bergfeld, Leon, Bethke, Norma, Bleicker, Tobias, Briesemeister, Dana, Brumhard, Sophia, Conrad, Claudia, Dieckmann, Sebastian, Frey, Doris, Gabelich, Julie-Anne, Georg, Philipp, Gläser, Ute, Hasler, Lisbeth, Hetey, Andreas, Hiller, Anna Luisa, Horn, Alexandra, Hülso, Claudia, Kegel, Luisa, Koch, Willi, Krannich, Alexander, Kroneberg, Paolo, Lisy, Michelle, Mackeldanz, Petra, Maeß, Birgit, Münn, Friederike, Olk, Nadine, Peiser, Christian, Pohl, Kai, Hermel, Annelie, Rönnefarth, Maria, Rubisch, Carolin, Sanchez Rezza, Angela, Schellenberger, Isabelle, Schenkel, Viktoria, Schlesinger, Jenny, Schmidt, Sein, Schwanitz, Georg, Sinnigen, Anne-Sophie, Stubbemann, Paula, Tesch, Julia, Treue, Denise, Wendisch, Daniel, Zvorc, Saskia, Hillus, David, Schwarz, Tatjana, Tober-Lau, Pinkus, Vanshylla, Kanika, Hastor, Hana, Thibeault, Charlotte, Jentzsch, Stefanie, Helbig, Elisa T, Lippert, Lena J, Tscheak, Patricia, Schmidt, Marie Luisa, Riege, Johanna, Solarek, André, von Kalle, Christof, Dang-Heine, Chantip, Gruell, Henning, Kopankiewicz, Piotr, Suttorp, Norbert, Drosten, Christian, Bias, Harald, Seybold, Joachim, Klein, Florian, Kurth, Florian, Corman, Victor Max, and Sander, Leif Erik

Published
2021
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5. A time-resolved proteomic and prognostic map of COVID-19

Author

Kleinschmidt, Malte, Heim, Katrin M., Millet, Belén, Meyer-Arndt, Lil, Hübner, Ralf H., Andermann, Tim, Doehn, Jan M., Opitz, Bastian, Sawitzki, Birgit, Grund, Daniel, Radünzel, Peter, Schürmann, Mariana, Zoller, Thomas, Alius, Florian, Knape, Philipp, Breitbart, Astrid, Li, Yaosi, Bremer, Felix, Pergantis, Panagiotis, Schürmann, Dirk, Temmesfeld-Wollbrück, Bettina, Wendisch, Daniel, Brumhard, Sophia, Haenel, Sascha S., Conrad, Claudia, Georg, Philipp, Eckardt, Kai-Uwe, Lehner, Lukas, Kruse, Jan M., Ferse, Carolin, Körner, Roland, Spies, Claudia, Edel, Andreas, Weber-Carstens, Steffen, Krannich, Alexander, Zvorc, Saskia, Li, Linna, Behrens, Uwe, Schmidt, Sein, Rönnefarth, Maria, Dang-Heine, Chantip, Röhle, Robert, Lieker, Emma, Kretzler, Lucie, Wirsching, Isabelle, Wollboldt, Christian, Wu, Yinan, Schwanitz, Georg, Hillus, David, Kasper, Stefanie, Olk, Nadine, Horn, Alexandra, Briesemeister, Dana, Treue, Denise, Hummel, Michael, Corman, Victor M., Drosten, Christian, von Kalle, Christof, Demichev, Vadim, Tober-Lau, Pinkus, Lemke, Oliver, Nazarenko, Tatiana, Thibeault, Charlotte, Whitwell, Harry, Röhl, Annika, Freiwald, Anja, Szyrwiel, Lukasz, Ludwig, Daniela, Correia-Melo, Clara, Aulakh, Simran Kaur, Helbig, Elisa T., Stubbemann, Paula, Lippert, Lena J., Grüning, Nana-Maria, Blyuss, Oleg, Vernardis, Spyros, White, Matthew, Messner, Christoph B., Joannidis, Michael, Sonnweber, Thomas, Klein, Sebastian J., Pizzini, Alex, Wohlfarter, Yvonne, Sahanic, Sabina, Hilbe, Richard, Schaefer, Benedikt, Wagner, Sonja, Mittermaier, Mirja, Machleidt, Felix, Garcia, Carmen, Ruwwe-Glösenkamp, Christoph, Lingscheid, Tilman, Bosquillon de Jarcy, Laure, Stegemann, Miriam S., Pfeiffer, Moritz, Jürgens, Linda, Denker, Sophy, Zickler, Daniel, Enghard, Philipp, Zelezniak, Aleksej, Campbell, Archie, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Uhrig, Alexander, Müller-Redetzky, Holger, Zoller, Heinz, Löffler-Ragg, Judith, Keller, Markus A., Tancevski, Ivan, Timms, John F., Zaikin, Alexey, Hippenstiel, Stefan, Ramharter, Michael, Witzenrath, Martin, Suttorp, Norbert, Lilley, Kathryn, Mülleder, Michael, Sander, Leif Erik, Ralser, Markus, and Kurth, Florian

Published
2021
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6. A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model

Author

Kreye, Jakob, Reincke, S. Momsen, Kornau, Hans-Christian, Sánchez-Sendin, Elisa, Corman, Victor Max, Liu, Hejun, Yuan, Meng, Wu, Nicholas C., Zhu, Xueyong, Lee, Chang-Chun D., Trimpert, Jakob, Höltje, Markus, Dietert, Kristina, Stöffler, Laura, von Wardenburg, Niels, van Hoof, Scott, Homeyer, Marie A., Hoffmann, Julius, Abdelgawad, Azza, Gruber, Achim D., Bertzbach, Luca D., Vladimirova, Daria, Li, Lucie Y., Barthel, Paula Charlotte, Skriner, Karl, Hocke, Andreas C., Hippenstiel, Stefan, Witzenrath, Martin, Suttorp, Norbert, Kurth, Florian, Franke, Christiana, Endres, Matthias, Schmitz, Dietmar, Jeworowski, Lara Maria, Richter, Anja, Schmidt, Marie Luisa, Schwarz, Tatjana, Müller, Marcel Alexander, Drosten, Christian, Wendisch, Daniel, Sander, Leif E., Osterrieder, Nikolaus, Wilson, Ian A., and Prüss, Harald

Published
2020
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7. Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Author

Angelov, Angel, Bals, Robert, Bartholomäus, Alexander, Becker, Anke, Bezdan, Daniela, Bonifacio, Ezio, Bork, Peer, Clavel, Thomas, Colome-Tatche, Maria, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Förstner, Konrad, Frick, Julia-Stefanie, Gagneur, Julien, Goesmann, Alexander, Hain, Torsten, Hummel, Michael, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keller, Andreas, Kim-Hellmuth, Sarah, Klein, Christoph, Kohlbacher, Oliver, Korbel, Jan O., Kurth, Ingo, Landthaler, Markus, Li, Yang, Ludwig, Kerstin, Makarewicz, Oliwia, Marz, Manja, McHardy, Alice, Mertes, Christian, Nöthen, Markus, Nürnberg, Peter, Ohler, Uwe, Ossowski, Stephan, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Poetsch, Anna R., Pühler, Alfred, Rajewsky, Nikolaus, Ralser, Markus, Rieß, Olaf, Ripke, Stephan, Nunes da Rocha, Ulisses, Rosenstiel, Philip, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Schiffer, Philipp, Schulte, Eva-Christina, Schultze, Joachim L., Sczyrba, Alexander, Stegle, Oliver, Stoye, Jens, Theis, Fabian, Vehreschild, Janne, Vogel, Jörg, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, Ziebuhr, John, Schulte-Schrepping, Jonas, Reusch, Nico, Paclik, Daniela, Baßler, Kevin, Schlickeiser, Stephan, Zhang, Bowen, Krämer, Benjamin, Krammer, Tobias, Brumhard, Sophia, Bonaguro, Lorenzo, De Domenico, Elena, Wendisch, Daniel, Grasshoff, Martin, Kapellos, Theodore S., Beckstette, Michael, Pecht, Tal, Saglam, Adem, Dietrich, Oliver, Mei, Henrik E., Schulz, Axel R., Conrad, Claudia, Kunkel, Désirée, Vafadarnejad, Ehsan, Xu, Cheng-Jian, Horne, Arik, Herbert, Miriam, Drews, Anna, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Hocke, Andreas, Müller-Redetzky, Holger, Heim, Katrin-Moira, Machleidt, Felix, Uhrig, Alexander, Bosquillon de Jarcy, Laure, Jürgens, Linda, Stegemann, Miriam, Glösenkamp, Christoph R., Volk, Hans-Dieter, Goffinet, Christine, Wyler, Emanuel, Georg, Philipp, Schneider, Maria, Dang-Heine, Chantip, Neuwinger, Nick, Kappert, Kai, Tauber, Rudolf, Corman, Victor, Raabe, Jan, Kaiser, Kim Melanie, Vinh, Michael To, Rieke, Gereon, Meisel, Christian, Ulas, Thomas, Becker, Matthias, Geffers, Robert, Witzenrath, Martin, Drosten, Christian, Suttorp, Norbert, von Kalle, Christof, Kurth, Florian, Händler, Kristian, Aschenbrenner, Anna C., and Nattermann, Jacob

Published
2020
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8. Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Author

Messner, Christoph B., Demichev, Vadim, Wendisch, Daniel, Michalick, Laura, White, Matthew, Freiwald, Anja, Textoris-Taube, Kathrin, Vernardis, Spyros I., Egger, Anna-Sophia, Kreidl, Marco, Ludwig, Daniela, Kilian, Christiane, Agostini, Federica, Zelezniak, Aleksej, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Hocke, Andreas, von Kalle, Christof, Campbell, Archie, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Langenberg, Claudia, Lilley, Kathryn S., Kuebler, Wolfgang M., Mülleder, Michael, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Kurth, Florian, Sander, Leif Erik, and Ralser, Markus

Published
2020
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9. SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Author

Braun, Julian, Loyal, Lucie, Frentsch, Marco, Wendisch, Daniel, Georg, Philipp, Kurth, Florian, and Hippenstiel, Stefan

Subjects
Glycoproteins -- Control, T cells -- Analysis, Organ donors -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic.sup.1,2. Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to respiratory failure. The mechanisms that determine such variable outcomes remain unresolved. Here we investigated CD4.sup.+ T cells that are reactive against the spike glycoprotein of SARS-CoV-2 in the peripheral blood of patients with COVID-19 and SARS-CoV-2-unexposed healthy donors. We detected spike-reactive CD4.sup.+ T cells not only in 83% of patients with COVID-19 but also in 35% of healthy donors. Spike-reactive CD4.sup.+ T cells in healthy donors were primarily active against C-terminal epitopes in the spike protein, which show a higher homology to spike glycoproteins of human endemic coronaviruses, compared with N-terminal epitopes. Spike-protein-reactive T cell lines generated from SARS-CoV-2-naive healthy donors responded similarly to the C-terminal region of the spike proteins of the human endemic coronaviruses 229E and OC43, as well as that of SARS-CoV-2. This results indicate that spike-protein cross-reactive T cells are present, which were probably generated during previous encounters with endemic coronaviruses. The effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined in larger cohorts. However, the presence of spike-protein cross-reactive T cells in a considerable fraction of the general population may affect the dynamics of the current pandemic, and has important implications for the design and analysis of upcoming trials investigating COVID-19 vaccines. A study of patients with COVID-19 and healthy donors found CD4.sup.+ T cells that react to the spike protein of SARS-CoV-2 and human endemic coronaviruses; however, the effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined., Author(s): Julian Braun [sup.1] [sup.2] , Lucie Loyal [sup.1] [sup.2] , Marco Frentsch [sup.3] , Daniel Wendisch [sup.4] , Philipp Georg [sup.5] , Florian Kurth [sup.4] [sup.5] [sup.6] , Stefan [...]

Published
2020
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10. COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

Author

Chua, Robert Lorenz, Lukassen, Soeren, Trump, Saskia, Hennig, Bianca P., Wendisch, Daniel, Pott, Fabian, Debnath, Olivia, Thürmann, Loreen, Kurth, Florian, Völker, Maria Theresa, Kazmierski, Julia, Timmermann, Bernd, Twardziok, Sven, Schneider, Stefan, Machleidt, Felix, Müller-Redetzky, Holger, Maier, Melanie, Krannich, Alexander, Schmidt, Sein, Balzer, Felix, Liebig, Johannes, Loske, Jennifer, Suttorp, Norbert, Eils, Jürgen, Ishaque, Naveed, Liebert, Uwe Gerd, von Kalle, Christof, Hocke, Andreas, Witzenrath, Martin, Goffinet, Christine, Drosten, Christian, Laudi, Sven, Lehmann, Irina, Conrad, Christian, Sander, Leif-Erik, and Eils, Roland

Published
2020
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11. Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses

Author

garaude, johan, primary, Lesbats, Juliette, additional, Brillac, Aurélia, additional, Haines, Julie, additional, Mukherjee, Parnika, additional, Fernández-Monreal, Mónica, additional, Dupuy, Jean-Wiliam, additional, Tioli, Gaia, additional, Calle, Celia De La, additional, Pinson, Benoit, additional, Wendisch, Daniel, additional, ROUSSEAU, Benoit, additional, Efeyan, Alejo, additional, D'Alessandro, Angelo, additional, and Sander, Leif, additional

Published
2024
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12. Monkeypox in-patients with severe anal pain

Author

Pfäfflin, Frieder, primary, Wendisch, Daniel, additional, Scherer, Roland, additional, Jürgens, Linda, additional, Godzick-Njomgang, Gisèle, additional, Tranter, Eva, additional, Tober-Lau, Pinkus, additional, Stegemann, Miriam Songa, additional, Corman, Victor Max, additional, Kurth, Florian, additional, and Schürmann, Dirk, additional

Published
2022
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13. Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

Author

Aznaourova, Marina, primary, Schmerer, Nils, additional, Janga, Harshavardhan, additional, Zhang, Zhenhua, additional, Pauck, Kim, additional, Hoppe, Judith, additional, Volkers, Sarah M, additional, Wendisch, Daniel, additional, Georg, Philipp, additional, Guendisch, Margrit, additional, Mack, Elisabeth, additional, Skevaki, Chrysanthi, additional, Keller, Christian, additional, Bauer, Christian, additional, Bertrams, Wilhelm, additional, Nist, Andrea, additional, Stiewe, Thorsten, additional, Gruber, Achim D, additional, Ruppert, Clemens, additional, Li, Yang, additional, Garn, Holger, additional, Sander, Leif E, additional, Schmeck, Bernd, additional, and Schulte, Leon N, additional

Published
2021
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14. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

Author

Hillus, David, primary, Schwarz, Tatjana, additional, Tober-Lau, Pinkus, additional, Vanshylla, Kanika, additional, Hastor, Hana, additional, Thibeault, Charlotte, additional, Jentzsch, Stefanie, additional, Helbig, Elisa T, additional, Lippert, Lena J, additional, Tscheak, Patricia, additional, Schmidt, Marie Luisa, additional, Riege, Johanna, additional, Solarek, André, additional, von Kalle, Christof, additional, Dang-Heine, Chantip, additional, Gruell, Henning, additional, Kopankiewicz, Piotr, additional, Suttorp, Norbert, additional, Drosten, Christian, additional, Bias, Harald, additional, Seybold, Joachim, additional, Klein, Florian, additional, Kurth, Florian, additional, Corman, Victor Max, additional, Sander, Leif Erik, additional, Al-Rim, Ben, additional, Bardtke, Lara, additional, Beheim-Schwarzbach, Jörn Ilmo, additional, Behn, Kerstin, additional, Bergfeld, Leon, additional, Bethke, Norma, additional, Bleicker, Tobias, additional, Briesemeister, Dana, additional, Brumhard, Sophia, additional, Conrad, Claudia, additional, Dieckmann, Sebastian, additional, Frey, Doris, additional, Gabelich, Julie-Anne, additional, Georg, Philipp, additional, Gläser, Ute, additional, Hasler, Lisbeth, additional, Hetey, Andreas, additional, Hiller, Anna Luisa, additional, Horn, Alexandra, additional, Hülso, Claudia, additional, Kegel, Luisa, additional, Koch, Willi, additional, Krannich, Alexander, additional, Kroneberg, Paolo, additional, Lisy, Michelle, additional, Mackeldanz, Petra, additional, Maeß, Birgit, additional, Münn, Friederike, additional, Olk, Nadine, additional, Peiser, Christian, additional, Pohl, Kai, additional, Hermel, Annelie, additional, Rönnefarth, Maria, additional, Rubisch, Carolin, additional, Sanchez Rezza, Angela, additional, Schellenberger, Isabelle, additional, Schenkel, Viktoria, additional, Schlesinger, Jenny, additional, Schmidt, Sein, additional, Schwanitz, Georg, additional, Sinnigen, Anne-Sophie, additional, Stubbemann, Paula, additional, Tesch, Julia, additional, Treue, Denise, additional, Wendisch, Daniel, additional, and Zvorc, Saskia, additional

Published
2021
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15. Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study

Author

Mühlemann, Barbara, primary, Thibeault, Charlotte, additional, Hillus, David, additional, Helbig, Elisa T., additional, Lippert, Lena J., additional, Tober-Lau, Pinkus, additional, Schwarz, Tatjana, additional, Müller, Marcel A., additional, Witzenrath, Martin, additional, Suttorp, Norbert, additional, Sander, Leif E., additional, Drosten, Christian, additional, Jones, Terry C., additional, Corman, Victor M., additional, Kurth, Florian, additional, Hippenstiel, Stefan, additional, Haenel, Sascha S., additional, Mittermaier, Mirja, additional, Steinbeis, Fridolin, additional, Lingscheid, Tilman, additional, Temmesfeld-Wollbrück, Bettina, additional, Zoller, Thomas, additional, Müller-Redetzky, Holger, additional, Uhrig, Alexander, additional, Grund, Daniel, additional, Ruwwe-Glösenkamp, Christoph, additional, Stegemann, Miriam S., additional, Heim, Katrin M., additional, Hübner, Ralf H., additional, Opitz, Bastian, additional, Eckardt, Kai-Uwe, additional, Möckel, Martin, additional, Balzer, Felix, additional, Spies, Claudia, additional, Weber-Carstens, Steffen, additional, Tacke, Frank, additional, Dang-Heine, Chantip, additional, Hummel, Michael, additional, Schwanitz, Georg, additional, Behrens, Uwe D., additional, Rönnefarth, Maria, additional, Schmidt, Sein, additional, Krannich, Alexander, additional, von Kalle, Christof, additional, Jürgens, Linda, additional, Kleinschmidt, Malte, additional, Denker, Sophy, additional, Pfeiffer, Moritz, additional, Pascual-Leone, Belén Millet, additional, Mrziglod, Luisa, additional, Machleidt, Felix, additional, Albus, Sebastian, additional, Bremer, Felix, additional, Doehn, Jan-Moritz, additional, Andermann, Tim, additional, Garcia, Carmen, additional, Knape, Philipp, additional, Krause, Philipp M., additional, Lechtenberg, Liron, additional, Li, Yaosi, additional, Pergantis, Panagiotis, additional, Jacobi, Till, additional, Ritter, Teresa, additional, Yedikat, Berna, additional, Pfannkuch, Lennart, additional, Zobel, Christian, additional, Kellermann, Ute, additional, Fieberg, Susanne, additional, Bosquillon de Jarcy, Laure, additional, Wetzel, Anne, additional, Tabeling, Christoph, additional, Brack, Markus C., additional, Müller-Plathe, Moritz, additional, Kruse, Jan M., additional, Zickler, Daniel, additional, Edel, Andreas, additional, Stier, Britta, additional, Körner, Roland, additional, Müller, Nils B., additional, Enghard, Philipp, additional, Stubbemann, Paula, additional, Olk, Nadine, additional, Koch, Willi M., additional, Horn, Alexandra, additional, Stoyanova, Katrin K., additional, Zvorc, Saskia, additional, Kretzler, Lucie, additional, Meyer-Arndt, Lil A., additional, Li, Linna, additional, Wirsching, Isabelle, additional, Treue, Denise, additional, Briesemeister, Dana, additional, Schlesinger, Jenny, additional, Sawitzki, Birgit, additional, Bardtke, Lara, additional, Pohl, Kai, additional, Georg, Philipp, additional, Wendisch, Daniel, additional, Hiller, Anna L., additional, Brumhard, Sophie, additional, Schmidt, Marie Luisa, additional, Meiners, Leonie, additional, and Tscheak, Patricia, additional

Published
2021
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16. A time-resolved proteomic and prognostic map of COVID-19

Author

Demichev, Vadim, primary, Tober-Lau, Pinkus, additional, Lemke, Oliver, additional, Nazarenko, Tatiana, additional, Thibeault, Charlotte, additional, Whitwell, Harry, additional, Röhl, Annika, additional, Freiwald, Anja, additional, Szyrwiel, Lukasz, additional, Ludwig, Daniela, additional, Correia-Melo, Clara, additional, Aulakh, Simran Kaur, additional, Helbig, Elisa T., additional, Stubbemann, Paula, additional, Lippert, Lena J., additional, Grüning, Nana-Maria, additional, Blyuss, Oleg, additional, Vernardis, Spyros, additional, White, Matthew, additional, Messner, Christoph B., additional, Joannidis, Michael, additional, Sonnweber, Thomas, additional, Klein, Sebastian J., additional, Pizzini, Alex, additional, Wohlfarter, Yvonne, additional, Sahanic, Sabina, additional, Hilbe, Richard, additional, Schaefer, Benedikt, additional, Wagner, Sonja, additional, Mittermaier, Mirja, additional, Machleidt, Felix, additional, Garcia, Carmen, additional, Ruwwe-Glösenkamp, Christoph, additional, Lingscheid, Tilman, additional, Bosquillon de Jarcy, Laure, additional, Stegemann, Miriam S., additional, Pfeiffer, Moritz, additional, Jürgens, Linda, additional, Denker, Sophy, additional, Zickler, Daniel, additional, Enghard, Philipp, additional, Zelezniak, Aleksej, additional, Campbell, Archie, additional, Hayward, Caroline, additional, Porteous, David J., additional, Marioni, Riccardo E., additional, Uhrig, Alexander, additional, Müller-Redetzky, Holger, additional, Zoller, Heinz, additional, Löffler-Ragg, Judith, additional, Keller, Markus A., additional, Tancevski, Ivan, additional, Timms, John F., additional, Zaikin, Alexey, additional, Hippenstiel, Stefan, additional, Ramharter, Michael, additional, Witzenrath, Martin, additional, Suttorp, Norbert, additional, Lilley, Kathryn, additional, Mülleder, Michael, additional, Sander, Leif Erik, additional, Ralser, Markus, additional, Kurth, Florian, additional, Kleinschmidt, Malte, additional, Heim, Katrin M., additional, Millet, Belén, additional, Meyer-Arndt, Lil, additional, Hübner, Ralf H., additional, Andermann, Tim, additional, Doehn, Jan M., additional, Opitz, Bastian, additional, Sawitzki, Birgit, additional, Grund, Daniel, additional, Radünzel, Peter, additional, Schürmann, Mariana, additional, Zoller, Thomas, additional, Alius, Florian, additional, Knape, Philipp, additional, Breitbart, Astrid, additional, Li, Yaosi, additional, Bremer, Felix, additional, Pergantis, Panagiotis, additional, Schürmann, Dirk, additional, Temmesfeld-Wollbrück, Bettina, additional, Wendisch, Daniel, additional, Brumhard, Sophia, additional, Haenel, Sascha S., additional, Conrad, Claudia, additional, Georg, Philipp, additional, Eckardt, Kai-Uwe, additional, Lehner, Lukas, additional, Kruse, Jan M., additional, Ferse, Carolin, additional, Körner, Roland, additional, Spies, Claudia, additional, Edel, Andreas, additional, Weber-Carstens, Steffen, additional, Krannich, Alexander, additional, Zvorc, Saskia, additional, Li, Linna, additional, Behrens, Uwe, additional, Schmidt, Sein, additional, Rönnefarth, Maria, additional, Dang-Heine, Chantip, additional, Röhle, Robert, additional, Lieker, Emma, additional, Kretzler, Lucie, additional, Wirsching, Isabelle, additional, Wollboldt, Christian, additional, Wu, Yinan, additional, Schwanitz, Georg, additional, Hillus, David, additional, Kasper, Stefanie, additional, Olk, Nadine, additional, Horn, Alexandra, additional, Briesemeister, Dana, additional, Treue, Denise, additional, Hummel, Michael, additional, Corman, Victor M., additional, Drosten, Christian, additional, and von Kalle, Christof, additional

Published
2021
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17. Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Author

Schulte-Schrepping, Jonas, primary, Reusch, Nico, additional, Paclik, Daniela, additional, Baßler, Kevin, additional, Schlickeiser, Stephan, additional, Zhang, Bowen, additional, Krämer, Benjamin, additional, Krammer, Tobias, additional, Brumhard, Sophia, additional, Bonaguro, Lorenzo, additional, De Domenico, Elena, additional, Wendisch, Daniel, additional, Grasshoff, Martin, additional, Kapellos, Theodore S., additional, Beckstette, Michael, additional, Pecht, Tal, additional, Saglam, Adem, additional, Dietrich, Oliver, additional, Mei, Henrik E., additional, Schulz, Axel R., additional, Conrad, Claudia, additional, Kunkel, Désirée, additional, Vafadarnejad, Ehsan, additional, Xu, Cheng-Jian, additional, Horne, Arik, additional, Herbert, Miriam, additional, Drews, Anna, additional, Thibeault, Charlotte, additional, Pfeiffer, Moritz, additional, Hippenstiel, Stefan, additional, Hocke, Andreas, additional, Müller-Redetzky, Holger, additional, Heim, Katrin-Moira, additional, Machleidt, Felix, additional, Uhrig, Alexander, additional, Bosquillon de Jarcy, Laure, additional, Jürgens, Linda, additional, Stegemann, Miriam, additional, Glösenkamp, Christoph R., additional, Volk, Hans-Dieter, additional, Goffinet, Christine, additional, Landthaler, Markus, additional, Wyler, Emanuel, additional, Georg, Philipp, additional, Schneider, Maria, additional, Dang-Heine, Chantip, additional, Neuwinger, Nick, additional, Kappert, Kai, additional, Tauber, Rudolf, additional, Corman, Victor, additional, Raabe, Jan, additional, Kaiser, Kim Melanie, additional, Vinh, Michael To, additional, Rieke, Gereon, additional, Meisel, Christian, additional, Ulas, Thomas, additional, Becker, Matthias, additional, Geffers, Robert, additional, Witzenrath, Martin, additional, Drosten, Christian, additional, Suttorp, Norbert, additional, von Kalle, Christof, additional, Kurth, Florian, additional, Händler, Kristian, additional, Schultze, Joachim L., additional, Aschenbrenner, Anna C., additional, Li, Yang, additional, Nattermann, Jacob, additional, Sawitzki, Birgit, additional, Saliba, Antoine-Emmanuel, additional, Sander, Leif Erik, additional, Angelov, Angel, additional, Bals, Robert, additional, Bartholomäus, Alexander, additional, Becker, Anke, additional, Bezdan, Daniela, additional, Bonifacio, Ezio, additional, Bork, Peer, additional, Clavel, Thomas, additional, Colome-Tatche, Maria, additional, Diefenbach, Andreas, additional, Dilthey, Alexander, additional, Fischer, Nicole, additional, Förstner, Konrad, additional, Frick, Julia-Stefanie, additional, Gagneur, Julien, additional, Goesmann, Alexander, additional, Hain, Torsten, additional, Hummel, Michael, additional, Janssen, Stefan, additional, Kalinowski, Jörn, additional, Kallies, René, additional, Kehr, Birte, additional, Keller, Andreas, additional, Kim-Hellmuth, Sarah, additional, Klein, Christoph, additional, Kohlbacher, Oliver, additional, Korbel, Jan O., additional, Kurth, Ingo, additional, Ludwig, Kerstin, additional, Makarewicz, Oliwia, additional, Marz, Manja, additional, McHardy, Alice, additional, Mertes, Christian, additional, Nöthen, Markus, additional, Nürnberg, Peter, additional, Ohler, Uwe, additional, Ossowski, Stephan, additional, Overmann, Jörg, additional, Peter, Silke, additional, Pfeffer, Klaus, additional, Poetsch, Anna R., additional, Pühler, Alfred, additional, Rajewsky, Nikolaus, additional, Ralser, Markus, additional, Rieß, Olaf, additional, Ripke, Stephan, additional, Nunes da Rocha, Ulisses, additional, Rosenstiel, Philip, additional, Schiffer, Philipp, additional, Schulte, Eva-Christina, additional, Sczyrba, Alexander, additional, Stegle, Oliver, additional, Stoye, Jens, additional, Theis, Fabian, additional, Vehreschild, Janne, additional, Vogel, Jörg, additional, von Kleist, Max, additional, Walker, Andreas, additional, Walter, Jörn, additional, Wieczorek, Dagmar, additional, and Ziebuhr, John, additional

Published
2020
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18. A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

Author

Kreye, Jakob, primary, Reincke, S Momsen, additional, Kornau, Hans-Christian, additional, Sánchez-Sendin, Elisa, additional, Corman, Victor Max, additional, Liu, Hejun, additional, Yuan, Meng, additional, Wu, Nicholas C., additional, Zhu, Xueyong, additional, Lee, Chang-Chun D., additional, Trimpert, Jakob, additional, Höltje, Markus, additional, Dietert, Kristina, additional, Stöffler, Laura, additional, von Wardenburg, Niels, additional, van Hoof, Scott, additional, Homeyer, Marie A, additional, Hoffmann, Julius, additional, Abdelgawad, Azza, additional, Gruber, Achim D, additional, Bertzbach, Luca D, additional, Vladimirova, Daria, additional, Li, Lucie Y, additional, Barthel, Paula Charlotte, additional, Skriner, Karl, additional, Hocke, Andreas C, additional, Hippenstiel, Stefan, additional, Witzenrath, Martin, additional, Suttorp, Norbert, additional, Kurth, Florian, additional, Franke, Christiana, additional, Endres, Matthias, additional, Schmitz, Dietmar, additional, Jeworowski, Lara Maria, additional, Richter, Anja, additional, Schmidt, Marie Luisa, additional, Schwarz, Tatjana, additional, Müller, Marcel Alexander, additional, Drosten, Christian, additional, Wendisch, Daniel, additional, Sander, Leif E, additional, Osterrieder, Nikolaus, additional, Wilson, Ian A, additional, and Prüss, Harald, additional

Published
2020
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19. Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19

Author

Chua, Robert Lorenz, primary, Lukassen, Soeren, additional, Trump, Saskia, additional, Hennig, Bianca P., additional, Wendisch, Daniel, additional, Pott, Fabian, additional, Debnath, Olivia, additional, Thürmann, Loreen, additional, Kurth, Florian, additional, Kazmierski, Julia, additional, Timmermann, Bernd, additional, Twardziok, Sven, additional, Schneider, Stefan, additional, Machleidt, Felix, additional, Müller-Redetzky, Holger, additional, Krannich, Alexander, additional, Schmidt, Sein, additional, Balzer, Felix, additional, Liebig, Johannes, additional, Loske, Jennifer, additional, Eils, Jürgen, additional, Ishaque, Naveed, additional, von Kalle, Christof, additional, Hocke, Andreas, additional, Witzenrath, Martin, additional, Goffinet, Christine, additional, Drosten, Christian, additional, Laudi, Sven, additional, Lehmann, Irina, additional, Conrad, Christian, additional, Sander, Leif-Erik, additional, and Eils, Roland, additional

Published
2020
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20. Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

Author

Messner, Christoph B., primary, Demichev, Vadim, additional, Wendisch, Daniel, additional, Michalick, Laura, additional, White, Matthew, additional, Freiwald, Anja, additional, Textoris-Taube, Kathrin, additional, Vernardis, Spyros I., additional, Egger, Anna-Sophia, additional, Kreidl, Marco, additional, Ludwig, Daniela, additional, Kilian, Christiane, additional, Agostini, Federica, additional, Zelezniak, Aleksej, additional, Thibeault, Charlotte, additional, Pfeiffer, Moritz, additional, Hippenstiel, Stefan, additional, Hocke, Andreas, additional, von Kalle, Christof, additional, Campbell, Archie, additional, Hayward, Caroline, additional, Porteous, David J., additional, Marioni, Riccardo E., additional, Langenberg, Claudia, additional, Lilley, Kathryn S., additional, Kuebler, Wolfgang M., additional, Mülleder, Michael, additional, Drosten, Christian, additional, Witzenrath, Martin, additional, Kurth, Florian, additional, Sander, Leif Erik, additional, and Ralser, Markus, additional

Published
2020
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21. Presence of SARS-CoV-2-reactive T cells in COVID-19 patients and healthy donors

Author

Braun, Julian, primary, Loyal, Lucie, additional, Frentsch, Marco, additional, Wendisch, Daniel, additional, Georg, Philipp, additional, Kurth, Florian, additional, Hippenstiel, Stefan, additional, Dingeldey, Manuela, additional, Kruse, Beate, additional, Fauchere, Florent, additional, Baysal, Emre, additional, Mangold, Maike, additional, Henze, Larissa, additional, Lauster, Roland, additional, Mall, Marcus A., additional, Beyer, Kirsten, additional, Röhmel, Jobst, additional, Schmitz, Jürgen, additional, Miltenyi, Stefan, additional, Demuth, Ilja, additional, Müller, Marcel A., additional, Witzenrath, Martin, additional, Suttorp, Norbert, additional, Kern, Florian, additional, Reimer, Ulf, additional, Wenschuh, Holger, additional, Drosten, Christian, additional, Corman, Victor M., additional, Giesecke-Thiel, Claudia, additional, Sander, Leif Erik, additional, and Thiel, Andreas, additional

Published
2020
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22. Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study

Author

Hippenstiel, Stefan, Haenel, Sascha S., Mittermaier, Mirja, Steinbeis, Fridolin, Lingscheid, Tilman, Temmesfeld-Wollbrück, Bettina, Zoller, Thomas, Müller-Redetzky, Holger, Uhrig, Alexander, Grund, Daniel, Ruwwe-Glösenkamp, Christoph, Stegemann, Miriam S., Heim, Katrin M., Hübner, Ralf H., Opitz, Bastian, Eckardt, Kai-Uwe, Möckel, Martin, Balzer, Felix, Spies, Claudia, Weber-Carstens, Steffen, Tacke, Frank, Dang-Heine, Chantip, Hummel, Michael, Schwanitz, Georg, Behrens, Uwe D., Rönnefarth, Maria, Schmidt, Sein, Krannich, Alexander, von Kalle, Christof, Jürgens, Linda, Kleinschmidt, Malte, Denker, Sophy, Pfeiffer, Moritz, Pascual-Leone, Belén Millet, Mrziglod, Luisa, Machleidt, Felix, Albus, Sebastian, Bremer, Felix, Doehn, Jan-Moritz, Andermann, Tim, Garcia, Carmen, Knape, Philipp, Krause, Philipp M., Lechtenberg, Liron, Li, Yaosi, Pergantis, Panagiotis, Jacobi, Till, Ritter, Teresa, Yedikat, Berna, Pfannkuch, Lennart, Zobel, Christian, Kellermann, Ute, Fieberg, Susanne, Bosquillon de Jarcy, Laure, Wetzel, Anne, Tabeling, Christoph, Brack, Markus C., Müller-Plathe, Moritz, Kruse, Jan M., Zickler, Daniel, Edel, Andreas, Stier, Britta, Körner, Roland, Müller, Nils B., Enghard, Philipp, Stubbemann, Paula, Olk, Nadine, Koch, Willi M., Horn, Alexandra, Stoyanova, Katrin K., Zvorc, Saskia, Kretzler, Lucie, Meyer-Arndt, Lil A., Li, Linna, Wirsching, Isabelle, Treue, Denise, Briesemeister, Dana, Schlesinger, Jenny, Sawitzki, Birgit, Bardtke, Lara, Pohl, Kai, Georg, Philipp, Wendisch, Daniel, Hiller, Anna L., Brumhard, Sophie, Schmidt, Marie Luisa, Meiners, Leonie, Tscheak, Patricia, Mühlemann, Barbara, Thibeault, Charlotte, Hillus, David, Helbig, Elisa T., Lippert, Lena J., Tober-Lau, Pinkus, Schwarz, Tatjana, Müller, Marcel A., Witzenrath, Martin, Suttorp, Norbert, Sander, Leif E., Drosten, Christian, Jones, Terry C., Corman, Victor M., and Kurth, Florian

Published
2021
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23. Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Author

Messner, Christoph B, Demichev, Vadim, Wendisch, Daniel, Michalick, Laura, White, Matthew, Freiwald, Anja, Textoris-Taube, Kathrin, Vernardis, Spyros I, Egger, Anna-Sophia, Kreidl, Marco, Ludwig, Daniela, Kilian, Christiane, Agostini, Federica, Zelezniak, Aleksej, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Hocke, Andreas, Von Kalle, Christof, Campbell, Archie, Hayward, Caroline, Porteous, David J, Marioni, Riccardo E, Langenberg, Claudia, Lilley, Kathryn S, Kuebler, Wolfgang M, Mülleder, Michael, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Kurth, Florian, Sander, Leif Erik, and Ralser, Markus

Subjects
Adult, Aged, 80 and over, Male, Proteomics, SARS-CoV-2, Pneumonia, Viral, COVID-19, Blood Proteins, Middle Aged, clinical classifiers, 3. Good health, COVID-19 infection, Betacoronavirus, Young Adult, high-throughput proteomics, SWATH-MS, Humans, Female, antiviral immune response, Coronavirus Infections, Pandemics, Biomarkers, mass spectrometry, Aged
Abstract

The COVID-19 pandemic is an unprecedented global challenge, and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput serum and plasma proteomics that builds on ISO13485 standardization to facilitate simple implementation in regulated clinical laboratories. Our low-cost workflow handles up to 180 samples per day, enables high precision quantification, and reduces batch effects for large-scale and longitudinal studies. We use our platform on samples collected from a cohort of early hospitalized cases of the SARS-CoV-2 pandemic and identify 27 potential biomarkers that are differentially expressed depending on the WHO severity grade of COVID-19. They include complement factors, the coagulation system, inflammation modulators, and pro-inflammatory factors upstream and downstream of interleukin 6. All protocols and software for implementing our approach are freely available. In total, this work supports the development of routine proteomic assays to aid clinical decision making and generate hypotheses about potential COVID-19 therapeutic targets.

24. A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model.

Author

Kreye J, Reincke SM, Kornau HC, Sánchez-Sendin E, Max Corman V, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Höltje M, Dietert K, Stöffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Müller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, and Prüss H

Abstract

The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed characterization of virus-neutralizing antibodies and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. Among 598 human monoclonal antibodies (mAbs) from ten COVID-19 patients, we identified 40 strongly neutralizing mAbs. The most potent mAb CV07-209 neutralized authentic SARS-CoV-2 with IC50 of 3.1 ng/ml. Crystal structures of two mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 A revealed a direct block of ACE2 attachment. Interestingly, some of the near-germline SARS-CoV-2 neutralizing mAbs reacted with mammalian self-antigens. Prophylactic and therapeutic application of CV07-209 protected hamsters from SARS-CoV-2 infection, weight loss and lung pathology. Our results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection are a promising therapeutic strategy.

Published
2020
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