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Memories for events experienced during infancy and early childhood are rarely recollected later in life—a phenomenon termed infantile and childhood amnesia. The formation and retrieval of such episodic memories relies, in part, on the hippocampus. Characterizing the role of hippocampal development in offsetting infantile and childhood amnesia is key to understanding (i) why infantile and childhood amnesia occur and (ii) how episodic memory capacities develop in early ontogeny. Comparative research is necessary for this enterprise because many paradigms and techniques work better with humans or with non-human animals. The four papers in this symposium gather current work in developmental psychology, developmental cognitive neuroscience, and behavioral neuroscience that characterizes the complex and heterogenous developmental profile of behavioral gains in component processes underlying episodic memory capacity in humans and work on the mammalian hippocampus and how it accompanies development. By leveraging and triangulating multiple levels of analyses, we can gain insights that are unavailable using a siloed approach. This collection of work helps delineate clear future directions for a comparative approach in memory development.

IntroductionHeterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence.MethodsOur international working group, funded by the EU Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption.ResultsThis progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures.DiscussionA harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

Memory enables generalization to new situations, and memory specificity that preserves individual episodes. This study investigated generalization, memory specificity, and their overnight fate in 141 4‐ to 8‐year‐olds (computerized memory game; 71 females, tested 2020–2021 in Germany). The results replicated age effects in generalization and memory specificity, and a contingency of generalization on object conceptual properties and interobject semantic proximity. Age effects were stronger in generalization than in memory specificity, and generalization was more closely linked to the explicit regularity knowledge in older than in younger children. After an overnight delay, older children retained more generalized and specific memories and showed greater gains but only in generalization. These findings reveal distinct age differences in generalization and memory specificity across childhood. [ABSTRACT FROM AUTHOR]

This study investigated preparatory processes involved in adapting to changing episodic memory retrieval demands. Event-related potentials (ERPs) were recorded while participants performed a general old/new recognition task and a specific task that also required retrieval of perceptual details. The relevant task remained either constant or changed (predictably or randomly) across trials. Responses were slowed when participants switched from the specific to the general task but not vice versa. Hence, asymmetrical switch costs were observed, suggesting that retrieval preparation is dependent not only on the current retrieval goal but also influenced by recent retrieval attempts. Consistently, over posterior scalp regions ERPs associated with advance preparation were modulated by the preceding task, reflecting increased attentional selection requirements for the general task, and by the foreknowledge about the task sequence. When retrieval demands remained constant, frontal slow-waves elicited by retrieval-cues were more positive going for the specific task, indicating full implementation of a retrieval orientation that allows more efficient retrieval of perceptual details. (Contains 5 figures and 3 tables.)

The authors investigated the strategic component (i.e., elaboration and organization of episodic features) and the associative component (i.e., binding processes) of episodic memory and their interactions in 4 age groups (10-12, 13-15, 20-25, and 70-75 years of age). On the basis of behavioral and neural evidence, the authors hypothesized that the two components are functionally related but follow different life-span gradients. In a fully crossed design, age differences in recognition memory for single words versus word pairs (associative demand manipulation) were examined under instructions that emphasized item, pair, or elaborative-pair encoding (strategy manipulation). As predicted, the results showed that the strategic and associative components follow different life-span trajectories. Relative to younger adults, children's difficulties in episodic memory primarily reflected lower levels of strategic functioning. In contrast, older adults showed impairments in both strategic and associative components. The authors conclude that the comparison of strategic and associative components of episodic memory across the life span helps to delineate the two components' unique and interactive contributions to episodic memory performance. (Contains 3 figures, 5 footnotes, and 3 tables.)