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2,753 results on '"Werner, L."'

3. Black-silicon ultraviolet photodiodes achieve external quantum efficiency above 130%

Author

Garin, M., Heinonen, J., Werner, L., Pasanen, T. P., Vähänissi, V., Haarahiltunen, A., Juntunen, M., and Savin, H.

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science, Physics - Instrumentation and Detectors
Abstract

At present, ultraviolet sensors are utilized in numerous fields ranging from various spectroscopy applications via biotechnical innovations to industrial process control. Despite of this, the performance of current UV sensors is surprisingly poor. Here, we break the theoretical one photon - one electron barrier and demonstrate a device with a certified external quantum efficiency (EQE) above 130% in UV range without external amplification. The record high performance is obtained using a nanostructured silicon photodiode with self-induced junction. We show that the high efficiency is based on effective utilization of multiple carrier generation by impact ionization taking place in the nanostructures. While the results can readily have a significant impact on the UV-sensor industry, the underlying technological concept can be applied to other semiconductor materials, thereby extending above unity response to longer wavelengths and offering new perspectives for improving efficiencies beyond the Shockley-Queisser limit., Comment: Published in Physical Review Letters. Full citation details and link to the published manuscript were added to the document

Published
2019
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5. Reliability and validity of the Roche PD Mobile Application for remote monitoring of early Parkinson’s disease

Author

Florian Lipsmeier, Kirsten I. Taylor, Ronald B. Postuma, Ekaterina Volkova-Volkmar, Timothy Kilchenmann, Brit Mollenhauer, Atieh Bamdadian, Werner L. Popp, Wei-Yi Cheng, Yan-Ping Zhang, Detlef Wolf, Jens Schjodt-Eriksen, Anne Boulay, Hanno Svoboda, Wagner Zago, Gennaro Pagano, and Michael Lindemann

Subjects
Medicine, Science
Abstract

Abstract Digital health technologies enable remote and therefore frequent measurement of motor signs, potentially providing reliable and valid estimates of motor sign severity and progression in Parkinson’s disease (PD). The Roche PD Mobile Application v2 was developed to measure bradykinesia, bradyphrenia and speech, tremor, gait and balance. It comprises 10 smartphone active tests (with ½ tests administered daily), as well as daily passive monitoring via a smartphone and smartwatch. It was studied in 316 early-stage PD participants who performed daily active tests at home then carried a smartphone and wore a smartwatch throughout the day for passive monitoring (study NCT03100149). Here, we report baseline data. Adherence was excellent (96.29%). All pre-specified sensor features exhibited good-to-excellent test–retest reliability (median intraclass correlation coefficient = 0.9), and correlated with corresponding Movement Disorder Society–Unified Parkinson's Disease Rating Scale items (rho: 0.12–0.71). These findings demonstrate the preliminary reliability and validity of remote at-home quantification of motor sign severity with the Roche PD Mobile Application v2 in individuals with early PD.

Published
2022
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6. MIMO OTA Testing

Author

Kotterman, Wim, primary, Pedersen, Gert F., additional, Szini, Istvan, additional, Fan, Wei, additional, Rumney, Moray, additional, Gagern, Christoph, additional, Schroeder, Werner L., additional, and Lehne, Per H., additional

Published
2022
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10. National strategy for palliative care of severely ill and dying people and their relatives in pandemics (PallPan) in Germany - study protocol of a mixed-methods project

Author

Bausewein, C., Hodiamont, F., Berges, N., Ullrich, A., Gerlach, C., Oechsle, K., Pauli, B., Weber, J., Stiel, S., Schneider, N., Krumm, N., Rolke, R., Gebel, C., Jansky, M., Nauck, F., Wedding, U., van Oorschot, B., Roch, C., Werner, L., Fischer, M., Schallenburger, M., Reuters, M. C., Schwartz, J., Neukirchen, M., Gülay, A., Maus, K., Jaspers, B., Radbruch, L., Heckel, M., Klinger, I., Ostgathe, C., Kriesen, U., Junghanß, C., Lehmann, E., Gesell, D., Gauder, S., Boehlke, C., Becker, G., Pralong, A., Strupp, J., Leisse, C., Schloesser, K., Voltz, R., Jung, N., and Simon, S. T.

Published
2022
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12. Neurological manifestations in pediatric patients with COVID-19: case report

Author

Sandra C. Schult-Montoya, Paola R. Pichilingue-Torres, Werner L. Vásquez-Vidal, Elio O. Rodríguez-Mujica, and Mayra Juárez-Luna

Subjects
encefalitis, meningitis, convulsión, síndrome guillain barré, estado epiléptico, niños, Medicine, Medicine (General), R5-920
Abstract

The COVID-19 pandemic currently affects millions of people including the pediatric population. The clinical manifestations in children are diverse: respiratory, gastrointestinal, hematological, neurological and systemic. In order to describe the various clinical and neurological manifestations during the evolution of the disease, we documented a series of cases of pediatric patients with COVID-19. Various mechanisms are proposed through which SARS-CoV-2 would cause neurological injury (direct injury, secondary to an immune response, among others) with variable clinical characteristics (seizures, muscle weakness, sensorial disorder). Studies on clinical characteristics and prognostic factors in children and adolescents with SARS-CoV-2 are limited, therefore, this report provides a spectrum of neurological manifestations associated with SARS-CoV-2 in pediatric population.

Published
2021
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19. Rapid feedback on the effects of anticancer mitochondrially targeted tamoxifen using circulating tumor cells

Author

Klézl, P., primary, Kolostova, K., additional, Bielcikova, Z., additional, Stursa, J., additional, Werner, L., additional, Neuzil, J., additional, Balinthova, S., additional, Dvorakova, S., additional, Molnarova, L., additional, Pospisilova, E., additional, Gregusova, A., additional, Sonsky, J., additional, Grill, R., additional, and Bobek, V., additional

Published
2024
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21. Circulating α4β7+ Memory T Cells in Pediatric IBD Patients Express a Polyclonal T Cell Receptor Repertoire

Author

Gamliel A, Werner L, Pinsker M, Salamon N, Weiss B, and Shouval DS

Subjects
ibd, tcr, integrin, α4β7, t cells, immune repertoire, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Adir Gamliel,1,2 Lael Werner,1,2 Marina Pinsker,1,3 Naomi Salamon,1 Batia Weiss,1,2 Dror S Shouval1,2 1Pediatric Gastroenterology Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat Gan, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, IsraelCorrespondence: Dror S ShouvalPediatric Gastroenterology Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat Gan, IsraelTel +972-3-5305006Email dror.shouval@gmail.comBackground: The integrin α 4β 7 is highly expressed on activated T cells and is thought to direct homing of lymphocytes to the intestine. Since ulcerative colitis (UC) and Crohn’s disease (CD) are characterized by mucosal oligoclonal T cells’ expansion, we aimed to assess whether similar repertoire features are identified in circulating gut-specific memory T cells.Methods: Memory CD3+ T cells were isolated from blood samples of control subjects and patients with active UC or CD and then FACS-sorted into α 4β 7+ and α 4β 7− populations. DNA was extracted from each subset and subjected to next-generation sequencing of the TCRβ. Different repertoire characteristics were compared between α 4β 7+ and α 4β 7− subsets for each subject, and between groups.Results: The percentages of memory T cells and α 4β 7+ cells were comparable between groups. α 4β 7+ memory T cells displayed a polyclonal distribution, in control subjects and in UC or CD patients, with similar indices of diversity. Strikingly, the clonal overlap between α 4β 7+ and α 4β 7− T cells for each subject in all three groups was high, ranging between 20%– 50%. We were unable to identify shared T cell clones that were specific to one of the groups.Conclusion: α 4β 7+ memory T cells exhibited a polyclonal repertoire in both control subjects and patients with active inflammatory bowel disease, with high rates of overlap with α 4β 7− memory T cells. Our study, along with additional recent reports, may suggest that the suppression of intestinal inflammation by vedolizumab is independent of the drug’s effect on T cell migration to the gut.Keywords: IBD, TCR, integrin, α 4β 7, T cells, immune repertoire

Published
2020

22. Accelerated Muscle Deoxygenation in Aerobically Fit Subjects During Exhaustive Exercise Is Associated With the ACE Insertion Allele

Author

Benedikt Gasser, Martino V. Franchi, Severin Ruoss, Annika Frei, Werner L. Popp, David Niederseer, Silvio Catuogno, Walter O. Frey, and Martin Flück

Subjects
cycling, aerobic metabolism, oxygen saturation, gene, exhaustive pedaling, Sports, GV557-1198.995
Abstract

IntroductionThe insertion/deletion (I/D) polymorphism in the gene for the major regulator of vascular tone, angiotensin-converting enzyme-insertion/deletion (ACE-I/D) affects muscle capillarization and mitochondrial biogenesis with endurance training. We tested whether changes of leg muscle oxygen saturation (SmO2) during exhaustive exercise and recovery would depend on the aerobic fitness status and the ACE I/D polymorphism.MethodsIn total, 34 healthy subjects (age: 31.8 ± 10.2 years, 17 male, 17 female) performed an incremental exercise test to exhaustion. SmO2 in musculus vastus lateralis (VAS) and musculus gastrocnemius (GAS) was recorded with near-IR spectroscopy. Effects of the aerobic fitness status (based on a VO2peak cutoff value of 50 ml O2 min−1 kg−1) and the ACE-I/D genotype (detected by PCR) on kinetic parameters of muscle deoxygenation and reoxygenation were assessed with univariate ANOVA.ResultsDeoxygenation with exercise was comparable in VAS and GAS (p = 0.321). In both leg muscles, deoxygenation and reoxygenation were 1.5-fold higher in the fit than the unfit volunteers. Differences in muscle deoxygenation, but not VO2peak, were associated with gender-independent (p > 0.58) interaction effects between aerobic fitness × ACE-I/D genotype; being reflected in a 2-fold accelerated deoxygenation of VAS for aerobically fit than unfit ACE-II genotypes and a 2-fold higher deoxygenation of GAS for fit ACE-II genotypes than fit D-allele carriers.DiscussionAerobically fit subjects demonstrated increased rates of leg muscle deoxygenation and reoxygenation. Together with the higher muscle deoxygenation in aerobically fit ACE-II genotypes, this suggests that an ACE-I/D genotype-based personalization of training protocols might serve to best improve aerobic performance.

Published
2022
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23. A literatura de Expressão Alemã no Brasil e a Literatura Brasileira em Alemão em Tradução

Author

Werner L. Heidermann and Maria Aparecida Barbosa

Subjects
Translating and interpreting, P306-310
Abstract

O número temático Troca de olhares da Cadernos de Tradução constitui-se tanto de estudos sobre versões já disponíveis, como de indagações concernentes a traduções em processo, e a edição pretende servir de guia a iminentes projetos de tradução situados entre as duas línguas. Uma coleção, portanto, mas em desalinho natural e distante da pretensão de completude. Reunindo a exigência científica e acadêmica do exercício metodológico e sistemático ao desejo de fomentar o diálogo entre os pares dedicados à pesquisa e à tradução literária no interstício proposto, a organização acontece no ínterim de confinamento físico e gradual aproximação social virtual, tendência nas atuais circunstâncias.

Published
2021
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24. Opportunities for an African greenhouse gas observation system

Author

Merbold, Lutz, Scholes, Robert J., Acosta, Manuel, Beck, Johannes, Bombelli, Antonio, Fiedler, Bjoern, Grieco, Elisa, Helmschrot, Joerg, Hugo, Wim, Kasurinen, Ville, Kim, Dong-Gill, Körtzinger, Arne, Leitner, Sonja, López-Ballesteros, Ana, Ndisi, Mylene, Nickless, Aecia, Salmon, Emmanuel, Saunders, Matthew, Skjelvan, Ingunn, Vermeulen, Alexander T., and Kutsch, Werner L.

Published
2021
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25. Author Correction: The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data

Author

Pastorello, Gilberto, Trotta, Carlo, Canfora, Eleonora, Chu, Housen, Christianson, Danielle, Cheah, You-Wei, Poindexter, Cristina, Chen, Jiquan, Elbashandy, Abdelrahman, Humphrey, Marty, Isaac, Peter, Polidori, Diego, Reichstein, Markus, Ribeca, Alessio, van Ingen, Catharine, Vuichard, Nicolas, Zhang, Leiming, Amiro, Brian, Ammann, Christof, Arain, M. Altaf, Ardö, Jonas, Arkebauer, Timothy, Arndt, Stefan K., Arriga, Nicola, Aubinet, Marc, Aurela, Mika, Baldocchi, Dennis, Barr, Alan, Beamesderfer, Eric, Marchesini, Luca Belelli, Bergeron, Onil, Beringer, Jason, Bernhofer, Christian, Berveiller, Daniel, Billesbach, Dave, Black, Thomas Andrew, Blanken, Peter D., Bohrer, Gil, Boike, Julia, Bolstad, Paul V., Bonal, Damien, Bonnefond, Jean-Marc, Bowling, David R., Bracho, Rosvel, Brodeur, Jason, Brümmer, Christian, Buchmann, Nina, Burban, Benoit, Burns, Sean P., Buysse, Pauline, Cale, Peter, Cavagna, Mauro, Cellier, Pierre, Chen, Shiping, Chini, Isaac, Christensen, Torben R., Cleverly, James, Collalti, Alessio, Consalvo, Claudia, Cook, Bruce D., Cook, David, Coursolle, Carole, Cremonese, Edoardo, Curtis, Peter S., D’Andrea, Ettore, da Rocha, Humberto, Dai, Xiaoqin, Davis, Kenneth J., De Cinti, Bruno, de Grandcourt, Agnes, De Ligne, Anne, De Oliveira, Raimundo C., Delpierre, Nicolas, Desai, Ankur R., Di Bella, Carlos Marcelo, di Tommasi, Paul, Dolman, Han, Domingo, Francisco, Dong, Gang, Dore, Sabina, Duce, Pierpaolo, Dufrêne, Eric, Dunn, Allison, Dušek, Jiří, Eamus, Derek, Eichelmann, Uwe, ElKhidir, Hatim Abdalla M., Eugster, Werner, Ewenz, Cacilia M., Ewers, Brent, Famulari, Daniela, Fares, Silvano, Feigenwinter, Iris, Feitz, Andrew, Fensholt, Rasmus, Filippa, Gianluca, Fischer, Marc, Frank, John, Galvagno, Marta, Gharun, Mana, Gianelle, Damiano, Gielen, Bert, Gioli, Beniamino, Gitelson, Anatoly, Goded, Ignacio, Goeckede, Mathias, Goldstein, Allen H., Gough, Christopher M., Goulden, Michael L., Graf, Alexander, Griebel, Anne, Gruening, Carsten, Grünwald, Thomas, Hammerle, Albin, Han, Shijie, Han, Xingguo, Hansen, Birger Ulf, Hanson, Chad, Hatakka, Juha, He, Yongtao, Hehn, Markus, Heinesch, Bernard, Hinko-Najera, Nina, Hörtnagl, Lukas, Hutley, Lindsay, Ibrom, Andreas, Ikawa, Hiroki, Jackowicz-Korczynski, Marcin, Janouš, Dalibor, Jans, Wilma, Jassal, Rachhpal, Jiang, Shicheng, Kato, Tomomichi, Khomik, Myroslava, Klatt, Janina, Knohl, Alexander, Knox, Sara, Kobayashi, Hideki, Koerber, Georgia, Kolle, Olaf, Kosugi, Yoshiko, Kotani, Ayumi, Kowalski, Andrew, Kruijt, Bart, Kurbatova, Julia, Kutsch, Werner L., Kwon, Hyojung, Launiainen, Samuli, Laurila, Tuomas, Law, Bev, Leuning, Ray, Li, Yingnian, Liddell, Michael, Limousin, Jean-Marc, Lion, Marryanna, Liska, Adam J., Lohila, Annalea, López-Ballesteros, Ana, López-Blanco, Efrén, Loubet, Benjamin, Loustau, Denis, Lucas-Moffat, Antje, Lüers, Johannes, Ma, Siyan, Macfarlane, Craig, Magliulo, Vincenzo, Maier, Regine, Mammarella, Ivan, Manca, Giovanni, Marcolla, Barbara, Margolis, Hank A., Marras, Serena, Massman, William, Mastepanov, Mikhail, Matamala, Roser, Matthes, Jaclyn Hatala, Mazzenga, Francesco, McCaughey, Harry, McHugh, Ian, McMillan, Andrew M. S., Merbold, Lutz, Meyer, Wayne, Meyers, Tilden, Miller, Scott D., Minerbi, Stefano, Moderow, Uta, Monson, Russell K., Montagnani, Leonardo, Moore, Caitlin E., Moors, Eddy, Moreaux, Virginie, Moureaux, Christine, Munger, J. William, Nakai, Taro, Neirynck, Johan, Nesic, Zoran, Nicolini, Giacomo, Noormets, Asko, Northwood, Matthew, Nosetto, Marcelo, Nouvellon, Yann, Novick, Kimberly, Oechel, Walter, Olesen, Jørgen Eivind, Ourcival, Jean-Marc, Papuga, Shirley A., Parmentier, Frans-Jan, Paul-Limoges, Eugenie, Pavelka, Marian, Peichl, Matthias, Pendall, Elise, Phillips, Richard P., Pilegaard, Kim, Pirk, Norbert, Posse, Gabriela, Powell, Thomas, Prasse, Heiko, Prober, Suzanne M., Rambal, Serge, Rannik, Üllar, Raz-Yaseef, Naama, Rebmann, Corinna, Reed, David, de Dios, Victor Resco, Restrepo-Coupe, Natalia, Reverter, Borja R., Roland, Marilyn, Sabbatini, Simone, Sachs, Torsten, Saleska, Scott R., Sánchez-Cañete, Enrique P., Sanchez-Mejia, Zulia M., Schmid, Hans Peter, Schmidt, Marius, Schneider, Karl, Schrader, Frederik, Schroder, Ivan, Scott, Russell L., Sedlák, Pavel, Serrano-Ortíz, Penélope, Shao, Changliang, Shi, Peili, Shironya, Ivan, Siebicke, Lukas, Šigut, Ladislav, Silberstein, Richard, Sirca, Costantino, Spano, Donatella, Steinbrecher, Rainer, Stevens, Robert M., Sturtevant, Cove, Suyker, Andy, Tagesson, Torbern, Takanashi, Satoru, Tang, Yanhong, Tapper, Nigel, Thom, Jonathan, Tomassucci, Michele, Tuovinen, Juha-Pekka, Urbanski, Shawn, Valentini, Riccardo, van der Molen, Michiel, van Gorsel, Eva, van Huissteden, Ko, Varlagin, Andrej, Verfaillie, Joseph, Vesala, Timo, Vincke, Caroline, Vitale, Domenico, Vygodskaya, Natalia, Walker, Jeffrey P., Walter-Shea, Elizabeth, Wang, Huimin, Weber, Robin, Westermann, Sebastian, Wille, Christian, Wofsy, Steven, Wohlfahrt, Georg, Wolf, Sebastian, Woodgate, William, Li, Yuelin, Zampedri, Roberto, Zhang, Junhui, Zhou, Guoyi, Zona, Donatella, Agarwal, Deb, Biraud, Sebastien, Torn, Margaret, and Papale, Dario

Published
2021
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26. GermLine Variation in Superoxide Dismutase-2 (SOD2) and Survival Outcomes After Radiation Therapy for Prostate Cancer: Results of a Test and Validation Set Analysis

Author

Chan, June, Margalit, DN, Jordahl, KM, Werner, L, Wang, X, Gwo-Shu, M, Penney, KL, Batista, JL, and Martin, NE

Abstract

© 2015 Elsevier Inc. Background: Genetic variants in antioxidant pathways might decrease the efficacy of radiation therapy (RT) by suppressing the generation of reactive oxygen species. We studied the association between single nucleotide polymorphisms (SN

Published
2014

27. Narratives as approach to interpreter identity

Author

Werner L. Heidermann and Markus J. Weininger

Subjects
narratives, translation and conflict, intercultural identity, interpreter identity, Translating and interpreting, P306-310
Abstract

Translator and interpreter identity came into focus with the “cultural turn” in the first decade of the new millennium (PYM, 2004) and even more in the 2010s with the “sociological turn” in translation and interpreting studies (WOLF, 2012). In this paper we explore narratives as an approach to understanding complex and not rarely conflictive interpreter identities in two ways. In a theoretical sense we understand that interpreting is to process, adapt and reconstruct narratives in a cognitive way that is compatible with, accessible and acceptable for all parties involved, based on Humboldt (1999), Wittgenstein (1922), Eco (1986), Blikstein (1997), and others as well as on Baker (2006) who describes the world as a projection of conflicting narratives that are the same time the very reason for the need for interpreting and for identity conflicts of interpreters. On the other hand, we look at literary narratives about interpreters or written by interpreters to illustrate the findings of the first part of this article.

Published
2019
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31. Age-Dependent Asymmetry of Wrist Position Sense Is Not Influenced by Stochastic Tactile Stimulation

Author

Anna-Maria Georgarakis, Harshal A. Sonar, Mike D. Rinderknecht, Werner L. Popp, Jaime E. Duarte, Olivier Lambercy, Jamie Paik, Bernard J. Martin, Robert Riener, and Verena Klamroth-Marganska

Subjects
proprioception, motor control, stochastic resonance, noise-enhanced, vibration-induced, afferent stimulation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Stochastic stimulation has been shown to improve movement, balance, the sense of touch, and may also improve position sense. This stimulation can be non-invasive and may be a simple technology to enhance proprioception. In this study, we investigated whether sub-threshold stochastic tactile stimulation of mechanoreceptors reduces age-related errors in wrist position estimation. Fifteen young (24.5±1.5y) and 23 elderly (71.7±7.3y) unimpaired, right-handed adults completed a wrist position gauge-matching experiment. In each trial, the participant's concealed wrist was moved to a target position between 10 and 30° of wrist flexion or extension by a robotic manipulandum. The participant then estimated the wrist's position on a virtual gauge. During half of the trials, sub-threshold stochastic tactile stimulation was applied to the wrist muscle tendon areas. Stochastic stimulation did not significantly influence wrist position sense. In the elderly group, estimation errors decreased non-significantly when stimulation was applied compared to the trials without stimulation [mean constant error reduction Δμ(θconof)=0.8° in flexion and Δμ(θconoe)=0.7° in extension direction, p = 0.95]. This effect was less pronounced in the young group [Δμ(θcony)=0.2° in flexion and in extension direction, p = 0.99]. These improvements did not yield a relevant effect size (Cohen's d < 0.1). Estimation errors increased with target angle magnitude in both movement directions. In young participants, estimation errors were non-symmetric, with estimations in flexion [μ(θconyf)=1.8°, σ(θconyf)=7.0°] being significantly more accurate than in extension [μ(θconye)=8.3°, σ(θconye)=9.3°, p < 0.01]. This asymmetry was not present in the elderly group, where estimations in flexion [μ(θconof)=7.5°, σ(θconof)=9.8°] were similar to extension [μ(θconoe)=7.7°, σ(θconoe)=9.3°]. Hence, young and elderly participants performed equally in extension direction, whereas wrist position sense in flexion direction deteriorated with age (p < 0.01). Though unimpaired elderly adults did not benefit from stochastic stimulation, it cannot be deduced that individuals with more severe impairments of their sensory system do not profit from this treatment. While the errors in estimating wrist position are symmetric in flexion and extension in elderly adults, young adults are more accurate when estimating wrist flexion, an effect that has not been described before.

Published
2020
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32. Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment

Author

Shazia Ashraf, Hiroki Kudo, Jia Rao, Atsuo Kikuchi, Eugen Widmeier, Jennifer A. Lawson, Weizhen Tan, Tobias Hermle, Jillian K. Warejko, Shirlee Shril, Merlin Airik, Tilman Jobst-Schwan, Svjetlana Lovric, Daniela A. Braun, Heon Yung Gee, David Schapiro, Amar J. Majmundar, Carolin E. Sadowski, Werner L. Pabst, Ankana Daga, Amelie T. van der Ven, Johanna M. Schmidt, Boon Chuan Low, Anjali Bansal Gupta, Brajendra K. Tripathi, Jenny Wong, Kirk Campbell, Kay Metcalfe, Denny Schanze, Tetsuya Niihori, Hiroshi Kaito, Kandai Nozu, Hiroyasu Tsukaguchi, Ryojiro Tanaka, Kiyoshi Hamahira, Yasuko Kobayashi, Takumi Takizawa, Ryo Funayama, Keiko Nakayama, Yoko Aoki, Naonori Kumagai, Kazumoto Iijima, Henry Fehrenbach, Jameela A. Kari, Sherif El Desoky, Sawsan Jalalah, Radovan Bogdanovic, Nataša Stajić, Hildegard Zappel, Assel Rakhmetova, Sharon-Rose Wassmer, Therese Jungraithmayr, Juergen Strehlau, Aravind Selvin Kumar, Arvind Bagga, Neveen A. Soliman, Shrikant M. Mane, Lewis Kaufman, Douglas R. Lowy, Mohamad A. Jairajpuri, Richard P. Lifton, York Pei, Martin Zenker, Shigeo Kure, and Friedhelm Hildebrandt

Subjects
Science
Abstract

Nephrotic syndrome is the second most common chronic kidney disease but there are no targeted treatment strategies available. Here the authors identify mutations of six genes codifying for proteins involved in cytoskeleton remodelling and modulation of small GTPases in 17 families with nephrotic syndrome.

Published
2018
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35. The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data

Author

Pastorello, Gilberto, Trotta, Carlo, Canfora, Eleonora, Chu, Housen, Christianson, Danielle, Cheah, You-Wei, Poindexter, Cristina, Chen, Jiquan, Elbashandy, Abdelrahman, Humphrey, Marty, Isaac, Peter, Polidori, Diego, Reichstein, Markus, Ribeca, Alessio, van Ingen, Catharine, Vuichard, Nicolas, Zhang, Leiming, Amiro, Brian, Ammann, Christof, Arain, M. Altaf, Ardö, Jonas, Arkebauer, Timothy, Arndt, Stefan K., Arriga, Nicola, Aubinet, Marc, Aurela, Mika, Baldocchi, Dennis, Barr, Alan, Beamesderfer, Eric, Marchesini, Luca Belelli, Bergeron, Onil, Beringer, Jason, Bernhofer, Christian, Berveiller, Daniel, Billesbach, Dave, Black, Thomas Andrew, Blanken, Peter D., Bohrer, Gil, Boike, Julia, Bolstad, Paul V., Bonal, Damien, Bonnefond, Jean-Marc, Bowling, David R., Bracho, Rosvel, Brodeur, Jason, Brümmer, Christian, Buchmann, Nina, Burban, Benoit, Burns, Sean P., Buysse, Pauline, Cale, Peter, Cavagna, Mauro, Cellier, Pierre, Chen, Shiping, Chini, Isaac, Christensen, Torben R., Cleverly, James, Collalti, Alessio, Consalvo, Claudia, Cook, Bruce D., Cook, David, Coursolle, Carole, Cremonese, Edoardo, Curtis, Peter S., D’Andrea, Ettore, da Rocha, Humberto, Dai, Xiaoqin, Davis, Kenneth J., Cinti, Bruno De, Grandcourt, Agnes de, Ligne, Anne De, De Oliveira, Raimundo C., Delpierre, Nicolas, Desai, Ankur R., Di Bella, Carlos Marcelo, Tommasi, Paul di, Dolman, Han, Domingo, Francisco, Dong, Gang, Dore, Sabina, Duce, Pierpaolo, Dufrêne, Eric, Dunn, Allison, Dušek, Jiří, Eamus, Derek, Eichelmann, Uwe, ElKhidir, Hatim Abdalla M., Eugster, Werner, Ewenz, Cacilia M., Ewers, Brent, Famulari, Daniela, Fares, Silvano, Feigenwinter, Iris, Feitz, Andrew, Fensholt, Rasmus, Filippa, Gianluca, Fischer, Marc, Frank, John, Galvagno, Marta, Gharun, Mana, Gianelle, Damiano, Gielen, Bert, Gioli, Beniamino, Gitelson, Anatoly, Goded, Ignacio, Goeckede, Mathias, Goldstein, Allen H., Gough, Christopher M., Goulden, Michael L., Graf, Alexander, Griebel, Anne, Gruening, Carsten, Grünwald, Thomas, Hammerle, Albin, Han, Shijie, Han, Xingguo, Hansen, Birger Ulf, Hanson, Chad, Hatakka, Juha, He, Yongtao, Hehn, Markus, Heinesch, Bernard, Hinko-Najera, Nina, Hörtnagl, Lukas, Hutley, Lindsay, Ibrom, Andreas, Ikawa, Hiroki, Jackowicz-Korczynski, Marcin, Janouš, Dalibor, Jans, Wilma, Jassal, Rachhpal, Jiang, Shicheng, Kato, Tomomichi, Khomik, Myroslava, Klatt, Janina, Knohl, Alexander, Knox, Sara, Kobayashi, Hideki, Koerber, Georgia, Kolle, Olaf, Kosugi, Yoshiko, Kotani, Ayumi, Kowalski, Andrew, Kruijt, Bart, Kurbatova, Julia, Kutsch, Werner L., Kwon, Hyojung, Launiainen, Samuli, Laurila, Tuomas, Law, Bev, Leuning, Ray, Li, Yingnian, Liddell, Michael, Limousin, Jean-Marc, Lion, Marryanna, Liska, Adam J., Lohila, Annalea, López-Ballesteros, Ana, López-Blanco, Efrén, Loubet, Benjamin, Loustau, Denis, Lucas-Moffat, Antje, Lüers, Johannes, Ma, Siyan, Macfarlane, Craig, Magliulo, Vincenzo, Maier, Regine, Mammarella, Ivan, Manca, Giovanni, Marcolla, Barbara, Margolis, Hank A., Marras, Serena, Massman, William, Mastepanov, Mikhail, Matamala, Roser, Matthes, Jaclyn Hatala, Mazzenga, Francesco, McCaughey, Harry, McHugh, Ian, McMillan, Andrew M. S., Merbold, Lutz, Meyer, Wayne, Meyers, Tilden, Miller, Scott D., Minerbi, Stefano, Moderow, Uta, Monson, Russell K., Montagnani, Leonardo, Moore, Caitlin E., Moors, Eddy, Moreaux, Virginie, Moureaux, Christine, Munger, J. William, Nakai, Taro, Neirynck, Johan, Nesic, Zoran, Nicolini, Giacomo, Noormets, Asko, Northwood, Matthew, Nosetto, Marcelo, Nouvellon, Yann, Novick, Kimberly, Oechel, Walter, Olesen, Jørgen Eivind, Ourcival, Jean-Marc, Papuga, Shirley A., Parmentier, Frans-Jan, Paul-Limoges, Eugenie, Pavelka, Marian, Peichl, Matthias, Pendall, Elise, Phillips, Richard P., Pilegaard, Kim, Pirk, Norbert, Posse, Gabriela, Powell, Thomas, Prasse, Heiko, Prober, Suzanne M., Rambal, Serge, Rannik, Üllar, Raz-Yaseef, Naama, Rebmann, Corinna, Reed, David, Dios, Victor Resco de, Restrepo-Coupe, Natalia, Reverter, Borja R., Roland, Marilyn, Sabbatini, Simone, Sachs, Torsten, Saleska, Scott R., Sánchez-Cañete, Enrique P., Sanchez-Mejia, Zulia M., Schmid, Hans Peter, Schmidt, Marius, Schneider, Karl, Schrader, Frederik, Schroder, Ivan, Scott, Russell L., Sedlák, Pavel, Serrano-Ortíz, Penélope, Shao, Changliang, Shi, Peili, Shironya, Ivan, Siebicke, Lukas, Šigut, Ladislav, Silberstein, Richard, Sirca, Costantino, Spano, Donatella, Steinbrecher, Rainer, Stevens, Robert M., Sturtevant, Cove, Suyker, Andy, Tagesson, Torbern, Takanashi, Satoru, Tang, Yanhong, Tapper, Nigel, Thom, Jonathan, Tomassucci, Michele, Tuovinen, Juha-Pekka, Urbanski, Shawn, Valentini, Riccardo, van der Molen, Michiel, van Gorsel, Eva, van Huissteden, Ko, Varlagin, Andrej, Verfaillie, Joseph, Vesala, Timo, Vincke, Caroline, Vitale, Domenico, Vygodskaya, Natalia, Walker, Jeffrey P., Walter-Shea, Elizabeth, Wang, Huimin, Weber, Robin, Westermann, Sebastian, Wille, Christian, Wofsy, Steven, Wohlfahrt, Georg, Wolf, Sebastian, Woodgate, William, Li, Yuelin, Zampedri, Roberto, Zhang, Junhui, Zhou, Guoyi, Zona, Donatella, Agarwal, Deb, Biraud, Sebastien, Torn, Margaret, and Papale, Dario

Published
2020
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38. Author Correction: The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data

Author

Gilberto Pastorello, Carlo Trotta, Eleonora Canfora, Housen Chu, Danielle Christianson, You-Wei Cheah, Cristina Poindexter, Jiquan Chen, Abdelrahman Elbashandy, Marty Humphrey, Peter Isaac, Diego Polidori, Markus Reichstein, Alessio Ribeca, Catharine van Ingen, Nicolas Vuichard, Leiming Zhang, Brian Amiro, Christof Ammann, M. Altaf Arain, Jonas Ardö, Timothy Arkebauer, Stefan K. Arndt, Nicola Arriga, Marc Aubinet, Mika Aurela, Dennis Baldocchi, Alan Barr, Eric Beamesderfer, Luca Belelli Marchesini, Onil Bergeron, Jason Beringer, Christian Bernhofer, Daniel Berveiller, Dave Billesbach, Thomas Andrew Black, Peter D. Blanken, Gil Bohrer, Julia Boike, Paul V. Bolstad, Damien Bonal, Jean-Marc Bonnefond, David R. Bowling, Rosvel Bracho, Jason Brodeur, Christian Brümmer, Nina Buchmann, Benoit Burban, Sean P. Burns, Pauline Buysse, Peter Cale, Mauro Cavagna, Pierre Cellier, Shiping Chen, Isaac Chini, Torben R. Christensen, James Cleverly, Alessio Collalti, Claudia Consalvo, Bruce D. Cook, David Cook, Carole Coursolle, Edoardo Cremonese, Peter S. Curtis, Ettore D’Andrea, Humberto da Rocha, Xiaoqin Dai, Kenneth J. Davis, Bruno De Cinti, Agnes de Grandcourt, Anne De Ligne, Raimundo C. De Oliveira, Nicolas Delpierre, Ankur R. Desai, Carlos Marcelo Di Bella, Paul di Tommasi, Han Dolman, Francisco Domingo, Gang Dong, Sabina Dore, Pierpaolo Duce, Eric Dufrêne, Allison Dunn, Jiří Dušek, Derek Eamus, Uwe Eichelmann, Hatim Abdalla M. ElKhidir, Werner Eugster, Cacilia M. Ewenz, Brent Ewers, Daniela Famulari, Silvano Fares, Iris Feigenwinter, Andrew Feitz, Rasmus Fensholt, Gianluca Filippa, Marc Fischer, John Frank, Marta Galvagno, Mana Gharun, Damiano Gianelle, Bert Gielen, Beniamino Gioli, Anatoly Gitelson, Ignacio Goded, Mathias Goeckede, Allen H. Goldstein, Christopher M. Gough, Michael L. Goulden, Alexander Graf, Anne Griebel, Carsten Gruening, Thomas Grünwald, Albin Hammerle, Shijie Han, Xingguo Han, Birger Ulf Hansen, Chad Hanson, Juha Hatakka, Yongtao He, Markus Hehn, Bernard Heinesch, Nina Hinko-Najera, Lukas Hörtnagl, Lindsay Hutley, Andreas Ibrom, Hiroki Ikawa, Marcin Jackowicz-Korczynski, Dalibor Janouš, Wilma Jans, Rachhpal Jassal, Shicheng Jiang, Tomomichi Kato, Myroslava Khomik, Janina Klatt, Alexander Knohl, Sara Knox, Hideki Kobayashi, Georgia Koerber, Olaf Kolle, Yoshiko Kosugi, Ayumi Kotani, Andrew Kowalski, Bart Kruijt, Julia Kurbatova, Werner L. Kutsch, Hyojung Kwon, Samuli Launiainen, Tuomas Laurila, Bev Law, Ray Leuning, Yingnian Li, Michael Liddell, Jean-Marc Limousin, Marryanna Lion, Adam J. Liska, Annalea Lohila, Ana López-Ballesteros, Efrén López-Blanco, Benjamin Loubet, Denis Loustau, Antje Lucas-Moffat, Johannes Lüers, Siyan Ma, Craig Macfarlane, Vincenzo Magliulo, Regine Maier, Ivan Mammarella, Giovanni Manca, Barbara Marcolla, Hank A. Margolis, Serena Marras, William Massman, Mikhail Mastepanov, Roser Matamala, Jaclyn Hatala Matthes, Francesco Mazzenga, Harry McCaughey, Ian McHugh, Andrew M. S. McMillan, Lutz Merbold, Wayne Meyer, Tilden Meyers, Scott D. Miller, Stefano Minerbi, Uta Moderow, Russell K. Monson, Leonardo Montagnani, Caitlin E. Moore, Eddy Moors, Virginie Moreaux, Christine Moureaux, J. William Munger, Taro Nakai, Johan Neirynck, Zoran Nesic, Giacomo Nicolini, Asko Noormets, Matthew Northwood, Marcelo Nosetto, Yann Nouvellon, Kimberly Novick, Walter Oechel, Jørgen Eivind Olesen, Jean-Marc Ourcival, Shirley A. Papuga, Frans-Jan Parmentier, Eugenie Paul-Limoges, Marian Pavelka, Matthias Peichl, Elise Pendall, Richard P. Phillips, Kim Pilegaard, Norbert Pirk, Gabriela Posse, Thomas Powell, Heiko Prasse, Suzanne M. Prober, Serge Rambal, Üllar Rannik, Naama Raz-Yaseef, Corinna Rebmann, David Reed, Victor Resco de Dios, Natalia Restrepo-Coupe, Borja R. Reverter, Marilyn Roland, Simone Sabbatini, Torsten Sachs, Scott R. Saleska, Enrique P. Sánchez-Cañete, Zulia M. Sanchez-Mejia, Hans Peter Schmid, Marius Schmidt, Karl Schneider, Frederik Schrader, Ivan Schroder, Russell L. Scott, Pavel Sedlák, Penélope Serrano-Ortíz, Changliang Shao, Peili Shi, Ivan Shironya, Lukas Siebicke, Ladislav Šigut, Richard Silberstein, Costantino Sirca, Donatella Spano, Rainer Steinbrecher, Robert M. Stevens, Cove Sturtevant, Andy Suyker, Torbern Tagesson, Satoru Takanashi, Yanhong Tang, Nigel Tapper, Jonathan Thom, Michele Tomassucci, Juha-Pekka Tuovinen, Shawn Urbanski, Riccardo Valentini, Michiel van der Molen, Eva van Gorsel, Ko van Huissteden, Andrej Varlagin, Joseph Verfaillie, Timo Vesala, Caroline Vincke, Domenico Vitale, Natalia Vygodskaya, Jeffrey P. Walker, Elizabeth Walter-Shea, Huimin Wang, Robin Weber, Sebastian Westermann, Christian Wille, Steven Wofsy, Georg Wohlfahrt, Sebastian Wolf, William Woodgate, Yuelin Li, Roberto Zampedri, Junhui Zhang, Guoyi Zhou, Donatella Zona, Deb Agarwal, Sebastien Biraud, Margaret Torn, and Dario Papale

Subjects
Science
Abstract

A Correction to this paper has been published: https://doi.org/10.1038/s41597-021-00851-9.

Published
2021
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39. Pair programming improves student retention, confidence, and program quality

Author

McDowell, C, Werner, L, Bullock, H E, and Fernald, J

Subjects
pair programming, computer science education, women in computer science
Abstract

Pair programming, when used as a form of collaborative learning, has been shown to increase the number of women (and men) persisting in their previously stated intent to pursue degrees in computer science. In addition, paired teams have been found to significantly outperform individual programmers in terms of program functionality and readability, to report greater satisfaction with the problem-solving process, to have greater confidence in their solutions, and to be more likely to complete a programming assignment. Nevertheless, many instructors continue to require students to complete programming assignments independently. Presumably, continued reliance on solo programming in academic settings is rooted in instructor concern that at least one of the partners in a pair will not learn as much as they would if they completed the assignment alone. In the worst case, one member of the pair might do essentially all of the work.We investigated the effects of pair programming on student performance and subsequent pursuit of computer science related degrees among both female and male college students taking an introductory programming course designed for computer science related majors (computer science, computer engineering, and information systems management). The results of this study provide some of the most compelling evidence to date of the effectiveness of pair programming as a pedagogical tool.

Published
2006

43. Affective recognition and social freedom - the psychoanalytic and normative-reconstructive logics of grounding social critique in Axel Honneth’s work

Author

Euler Werner L.

Subjects
Honneth, Hegel, Freud, recognition, social critique, law, self-consciousness, desire, negation, freedom, Philosophy (General), B1-5802
Abstract

The task of this paper is the following: how should one explain and solve the theory-immanent tension in Honneth’s recent works, i.e. the tension that reflects the difference between the concept of social freedom (a concept grounded in Hegel’s social philosophy methodologically articulated through normative reconstruction) and the concept of ‘affective recognition’ (which has replaced the earlier normative concept) - in other words: is there a certain logically-factually grounded path from the question of subjective-individual recognition to the intersubjective recognition of free (legal) subjects in society? My thesis is the fol­lowing: this supposed tension is a pseudo-tension. It loosens up - without completely resolving itself - as soon as we combine the two logics of grounding critique that we find in Honneth. However, unrelated to my claim about the pseudo-nature of the mentioned tension, the psychoanalytic mode of grounding critique is erroneous, since one cannot directly arrive at collective components of society starting from the empirical constellation of individual consciousnesses. The relation between subjective individuality and objective (intersubjective) generality is an objective contradiction (as opposed to a purely theoretical tension). If we still decide to pursue this path of grounding critique, we inadvertently introduce a psychologistic approach into social theory. Such an approach can be found in Honneth’s theory of intersubjective (normative) recognition as well.

Published
2017
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47. Pricing uncertainty in stochastic multi-stage electricity markets

Author

Werner, L. (Lucien), Christianson, N. (Nicolas), Zocca, A. (Alessandro), Wierman, A. (Adam), Low, S. (Steven), Werner, L. (Lucien), Christianson, N. (Nicolas), Zocca, A. (Alessandro), Wierman, A. (Adam), and Low, S. (Steven)

Abstract

This work proposes a pricing mechanism for multi-stage electricity markets that does not explicitly depend on the choice of dispatch procedure or optimization method. Our approach is applicable to a wide range of methodologies for the economic dispatch of power systems under uncertainty, including multi-interval dispatch, multi-settlement markets, scenario-based dispatch, and chance-constrained dispatch policies. We prove that our pricing scheme provides both ex-ante and expost dispatch-following incentives by simultaneously supporting per-stage and ex-post competitive equilibria. In numerical experiments on a ramp-constrained test system, we demonstrate the benefits of scheduling under uncertainty and show how our price decomposes into components corresponding to energy, intertemporal coupling, and uncertainty.

Published
2023
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48. Wearable Sensors in Ambulatory Individuals With a Spinal Cord Injury: From Energy Expenditure Estimation to Activity Recommendations

Author

Werner L. Popp, Sophie Schneider, Jessica Bär, Philipp Bösch, Christina M. Spengler, Roger Gassert, and Armin Curt

Subjects
energy expenditure, spinal cord injury, wearable sensor, estimation model, pathological gait, activity recommendation, Neurology. Diseases of the nervous system, RC346-429
Abstract

Inappropriate physical inactivity is a global health problem increasing the risk of cardiometabolic diseases. Wearable sensors show great potential to promote physical activity and thus a healthier lifestyle. While commercial activity trackers are available to estimate energy expenditure (EE) in non-disabled individuals, they are not designed for reliable assessments in individuals with an incomplete spinal cord injury (iSCI). Furthermore, activity recommendations for this population are currently rather vague and not tailored to their individual needs, and activity guidelines provided for the non-disabled population may not be easily translated for this population. However, especially in iSCI individuals with impaired abilities to stand and walk, the assessment of physical activities and appropriate recommendations for a healthy lifestyle are challenging. Therefore, the study aimed at developing an EE estimation model for iSCI individuals able to walk based on wearable sensor data. Additionally, the data collected within this study was used to translate common activity recommendations for the non-disabled population to easily understandable activity goals for ambulatory individuals with an iSCI. In total, 30 ambulatory individuals with an iSCI were equipped with wearable sensors while performing 12 different physical activities. EE was measured continuously and demographic and anthropometric variables, clinical assessment scores as well as wearable-sensor-derived features were used to develop different EE estimation models. The best EE estimation model comprised the estimation of resting EE using the updated Harris-Benedict equation, classifying activities using a k-nearest neighbor algorithm, and applying a multiple linear regression-based EE estimation model for each activity class. The mean absolute estimation error of this model was 15.2 ± 6.3% and the corresponding mean signed error was −3.4 ± 8.9%. Translating activity recommendations of global health institutions, we suggest a minimum of 2,000–3,000 steps per day for ambulatory individuals with an iSCI. If ambulatory individuals with an iSCI targeted the popular 10,000 steps a day recommendation for the non-disabled population, their equivalent would be around 8,000 steps a day. The combination of the presented dedicated EE estimation model for ambulatory individuals with an iSCI and the translated activity recommendations is an important step toward promoting an active lifestyle in this population.

Published
2019
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49. Does electrical stimulation in the lower urinary tract increase urine production? A randomised comparative proof-of-concept study in healthy volunteers.

Author

Stéphanie van der Lely, Martina D Liechti, Werner L Popp, Melanie R Schmidhalter, Thomas M Kessler, and Ulrich Mehnert

Subjects
Medicine, Science
Abstract

Trial designDuring electrical stimulation in the lower urinary tract for the purpose of current perception threshold and sensory evoked potential recording, we observed that bladder volume increased rapidly. The aim of this prospective randomised comparative proof-of-concept study was to quantify urine production per time during stimulation of the lower urinary tract using different stimulation frequencies.MethodsNinety healthy subjects (18 to 36 years old) were included. Forty females and 50 males were randomly assigned to one of the following study groups: dome, trigone or proximal, membranous (males only) or distal urethra. Starting from 60mL prefilling, stimulation was performed at two separate visits with a 14 French custom-made catheter using randomly applied frequencies of 0.5Hz, 1.1Hz, 1.6Hz (each with 500 stimuli). After each stimulation cycle per frequency, urine production was assessed. Main outcome measures represented urine production during stimulation, daily life and their ratio.ResultsLower urinary tract electrical stimulation increased urine production per time compared to bladder diary baseline values. Linear mixed model showed that frequency (pConclusionsUrine production is increased during electrical stimulation with a bigger impact of higher frequencies. This might be relevant for methodological aspects in the assessment of lower urinary tract afferent function and for patients with impaired renal urine output. Inhibition of renal sympathetic nerve activity by vagal afferents may be the underlying mechanism.

Published
2019
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