18 results on '"Werner, Lena"'
Search Results
2. How Critical Thinking, Multicultural Education and Teacher Qualification Affect Anti-Immigrant Attitudes
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Hjerm, Mikael, Johansson Sevä, Ingemar, and Werner, Lena
- Abstract
Previous studies identify a relationship between education and anti-immigrant attitudes. There is, however, uncertainty regarding the underlying explanations linking education to attitudes. In this article, we examine whether a relationship exists between exposure to teaching about critical thinking as well as multiculturalism (measured as religions/cultures as well as xenophobia/racism), and anti-immigrant attitudes among adolescents. In addition, we examine whether teacher qualification matters for attitudes. The analysis is based on survey data collected from high school students in Sweden. The results show an association between exposure to teaching about critical thinking as well as multiculturalism (both indicators) and anti-immigrant attitudes among students, i.e. higher exposure is related to lower levels of anti-immigrant attitudes. However, we find that teaching about xenophobia/racism affects attitudes, but not when simultaneously controlling for teaching about critical thinking and religions/cultures. In terms of teacher qualification, we find that students in schools with a high proportion of certified teachers tend to have lower levels of anti-immigrant attitudes.
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- 2018
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3. Local and systemic metabolic adjustments to drought in maize: Hydraulic redistribution in a split‐root system
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Werner, Lena Maria, primary, Hartwig, Roman Paul, additional, Engel, Isabelle, additional, Franzisky, Bastian Leander, additional, Wienkoop, Stefanie, additional, Brenner, Martin, additional, Preiner, Julian, additional, Repper, Dagmar, additional, Hartung, Jens, additional, Zörb, Christian, additional, and Wimmer, Monika Andrea, additional
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- 2022
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4. Migrantenunternehmer in Deutschland am Anfang des 21. Jahrhunderts: Marktstrategien im Kontext ethnischer und individueller Ressourcen
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Leicht, René and Werner, Lena
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- 2013
5. Root hairs: the villi of plants
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Bienert, Manuela Désirée, primary, Werner, Lena M., additional, Wimmer, Monika A., additional, and Bienert, Gerd Patrick, additional
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- 2021
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6. Was sie wissen, was sie brauchen: zum medientechnischen und mediendidaktischen Reflexionsbewusstsein von Grundschullehrkräften
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Delere, Malte, Marci-Boehncke, Gudrun, Schmidt, Jule Sophie, and Werner, Lena
- Abstract
k:ON - Kölner Online Journal für Lehrer*innenbildung, Bd. 1 Nr. 1 (2020): Wege zur digitalen Kompetenz im Spannungsfeld von Politik und Realität, Technische und didaktische Medienkompetenz von Lehrkräften spielen für die Medienerziehung in der Schule eine zentrale Rolle (vgl. Herzig, 2004). Obwohl sich Lehrkräfte in Deutschland in ihrer medientechnischen Kompetenz meist gut vorbereitet fühlen (ICILS, 2018; ICILS, 2013; Bos et al., 2016), stellen viele ihre mediendidaktischen Fähigkeiten in Frage. Lehrpläne und das DigCompEdu-Framework fordern eine digitale Medienerziehung, die Schüler*innen produktive digitale Arbeit ermöglicht. Diese Studie untersucht die Selbsteinschätzung digitaler Medienkompetenzen von Lehrkräften. Technical and didactic media literacy of teachers are considered central for media education in schools (Herzig, 2004). While teachers in Germany mostly feel well-prepared in their technical media competence (ICILS, 2013; ICILS, 2018; Bos et al., 2016), many question their media educational skills. School curriculums and the DigCompEdu Framework are calling for digital media education that has students actively create suitable digital output. This study examines the self-assessment of digital media competences of teachers.
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- 2020
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7. WHAT IS IT GOOD FOR? TEACHERS’ AND PARENTS’ VIEW ON DIGITAL MEDIA EDUCATION IN PRIMARY SCHOOLS
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Werner, Lena, primary, Schmidt, Jule S., additional, and Marci-Boehncke, Gudrun, additional
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- 2020
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8. Videographieren in der Lehramtsausbildung für das Fach Deutsch – ein Erfahrungsbericht aus studentischer Perspektive
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Werner, Lena
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Deutschunterricht ,Reflexion ,Video - Abstract
DoLiMette;1, 2019
- Published
- 2019
9. It's who you know and what you know : exploring the relationship between education and prejudice in adolescence
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Werner, Lena
- Subjects
education ,multicultural education ,friendship ,Sociology (excluding Social Work, Social Psychology and Social Anthropology) ,critical thinking ,Sociologi (exklusive socialt arbete, socialpsykologi och socialantropologi) ,teacher qualification ,intergroup contact theory ,secondary transfer effects ,anti-immigrant attitudes - Abstract
Background: Previous studies have consistently identified an association between higher levels of education and lower levels of anti-immigrant sentiment, but the underlying reasons for this relationship remain unclear. Therefore, this research aims to help explain why education matters for attitudes toward immigrants. This thesis consists of two studies, where in I examine the role of two features of education, specifically the aquistition of knowledge and social relationships. In the first study, I analyze how two aspects of teaching in schools are associated with anti-immigrant sentiment. I examine education as a means to knowledge by investigating whether the content of education, such as critical thinking and multicultural education, is inversely related to students' prejudice. I also look into the certification of teachers and whether this has a similar effect. In the second study, I investigate the school as an arena for social interaction and examine the relationship between outgroup contact and prejudiced attitudes. Previous research has found that outgroup contact, especially contact in the form of outgroup friendship, is effective in reducing prejudice. Based on these previous findings, I study how the Secondary Transfer Effect (STE) of friendship with a specific outgroup member is associated with attitudes towards other ethnic or racial groups. Method: The two studies rely on a cross-sectional survey of Swedish high school students (aged 16-18) administered by 'Forum för levande historia' (Forum for living history) and Statistics Sweden during the 2009-2010 academic year. Additionally, survey participants' responses are matched to registry data. This thesis also uses multilevel (MLM) and ordinary least squares (OLS) regression models. Results: Results show that both aspects of education are correlated with lower levels of anti-immigrant sentiment. The first study, in which education is a means to knowledge, demonstrates that education focused on critical thinking and multiculturalism are negatively correlated with anti-immigrant sentiment. Furthermore, results show that more exposure to teachings about xenophobia and racism is associated with less prejudice. However, when controlling for exposure to critical thinking, as well as learning about religions and cultures, the results show that exposure to learning about xenophobia and racism are no longer significant. Moreover, there is a negative association between exposure to teachers with a teaching certification or teaching degree and prejudice. Results from the second study, in which the school functions as an arena for social interaction, shows that positive attitudes associated with intergroup friendship not only generalize to the ethnic outgroup of that friend but, more importantly, also to other secondary outgroups. STEs are most frequently found where boundaries between ingroups and outgroups are perceived to be the thickest. Thus, the presence of STEs appears to be group-specific. Previous research on perceived social distance in Sweden and other countries help shed light on these findings. In summary, the results of this thesis provide evidence of two different complimentary accounts of the negative relationship between education and prejudice.
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- 2019
10. Neue Herausforderungen für die Aus- und Weiterbildung in Migrantenunternehmen
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Werner, Lena, Stegnos, Elvira, Leicht, René, and Münch, Monika
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In diesem Sammelband berichten Akteurinnen und Akteure aus Migrantenorganisationen, Bildungsträgern, kommunaler Verwaltung, Kammern und Forschungseinrichtungen über ihre Erfahrungen und Erkenntnisse bei der Fachkräfteentwicklung in Migrantenunternehmen. Die Impulse zur Entstehung dieses Buches gehen auf einen gleichnamigen Workshop zurück, der von der Landesarbeitsgemeinschaft Migrantenökonomie Baden-Württemberg ausgerichtet wurde und unter bundesweiter Beteiligung stattfand. Der Sammelband umfasst die dort vorgestellten Beiträge von Expertinnen und Experten, die aus ihren jeweiligen beruflichen Kontexten und Perspektiven die Aus- und Weiterbildung in Migrantenunternehmen betrachten. Die Beiträge machen deutlich, dass die Förderung der Aus- und Weiterbildung in Migrantenunternehmen sowohl hinsichtlich der Grundlagen als auch der Zielsetzungen auf neue Füße gestellt werden muss. Denn insgesamt ist ein anderer Blick auf Migrantenunternehmen erforderlich, da die an Quantität ausgerichteten Fragen der Ausbildungsbeteiligung an Bedeutung verlieren, während nunmehr in den Betrieben Herausforderungen ersichtlich werden, die stärker auf eine qualitative Dimension verweisen.
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- 2016
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11. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
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Rosendahl, Jonas, primary, Kirsten, Holger, additional, Hegyi, Eszter, additional, Kovacs, Peter, additional, Weiss, Frank Ulrich, additional, Laumen, Helmut, additional, Lichtner, Peter, additional, Ruffert, Claudia, additional, Chen, Jian-Min, additional, Masson, Emmanuelle, additional, Beer, Sebastian, additional, Zimmer, Constantin, additional, Seltsam, Katharina, additional, Algül, Hana, additional, Bühler, Florence, additional, Bruno, Marco J, additional, Bugert, Peter, additional, Burkhardt, Ralph, additional, Cavestro, Giulia Martina, additional, Cichoz-Lach, Halina, additional, Farré, Antoni, additional, Frank, Josef, additional, Gambaro, Giovanni, additional, Gimpfl, Sebastian, additional, Grallert, Harald, additional, Griesmann, Heidi, additional, Grützmann, Robert, additional, Hellerbrand, Claus, additional, Hegyi, Péter, additional, Hollenbach, Marcus, additional, Iordache, Sevastitia, additional, Jurkowska, Grazyna, additional, Keim, Volker, additional, Kiefer, Falk, additional, Krug, Sebastian, additional, Landt, Olfert, additional, Leo, Milena Di, additional, Lerch, Markus M, additional, Lévy, Philippe, additional, Löffler, Markus, additional, Löhr, Matthias, additional, Ludwig, Maren, additional, Macek, Milan, additional, Malats, Nuria, additional, Malecka-Panas, Ewa, additional, Malerba, Giovanni, additional, Mann, Karl, additional, Mayerle, Julia, additional, Mohr, Sonja, additional, te Morsche, Rene H M, additional, Motyka, Marie, additional, Mueller, Sebastian, additional, Müller, Thomas, additional, Nöthen, Markus M, additional, Pedrazzoli, Sergio, additional, Pereira, Stephen P, additional, Peters, Annette, additional, Pfützer, Roland, additional, Real, Francisco X, additional, Rebours, Vinciane, additional, Ridinger, Monika, additional, Rietschel, Marcella, additional, Rösmann, Eva, additional, Saftoiu, Adrian, additional, Schneider, Alexander, additional, Schulz, Hans-Ulrich, additional, Soranzo, Nicole, additional, Soyka, Michael, additional, Simon, Peter, additional, Skipworth, James, additional, Stickel, Felix, additional, Strauch, Konstantin, additional, Stumvoll, Michael, additional, Testoni, Pier Alberto, additional, Tönjes, Anke, additional, Werner, Lena, additional, Werner, Jens, additional, Wodarz, Norbert, additional, Ziegler, Martin, additional, Masamune, Atsushi, additional, Mössner, Joachim, additional, Férec, Claude, additional, Michl, Patrick, additional, P H Drenth, Joost, additional, Witt, Heiko, additional, Scholz, Markus, additional, and Sahin-Tóth, Miklós, additional
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- 2017
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12. Genome-wide association study identifies inversion in theCTRB1-CTRB2locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
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Rosendahl, Jona, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian-Min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algül, Hana, Bühler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, Giulia Martina, Cichoz-Lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grützmann, Robert, Hellerbrand, Clau, Hegyi, Péter, Hollenbach, Marcu, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lévy, Philippe, Löffler, Marku, Löhr, Matthia, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka-Panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, Te Morsche, Rene H M, Motyka, Marie, Mueller, Sebastian, Müller, Thoma, Nöthen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfützer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rösmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans-Ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, Jame, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, Pier Alberto, Tönjes, Anke, Werner, Lena, Werner, Jen, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mössner, Joachim, Férec, Claude, Michl, Patrick, P H Drenth, Joost, Witt, Heiko, Scholz, Marku, Sahin-Tóth, Miklós, Gambaro, Giovanni (ORCID:0000-0001-5733-2370), Rosendahl, Jona, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian-Min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algül, Hana, Bühler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, Giulia Martina, Cichoz-Lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grützmann, Robert, Hellerbrand, Clau, Hegyi, Péter, Hollenbach, Marcu, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lévy, Philippe, Löffler, Marku, Löhr, Matthia, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka-Panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, Te Morsche, Rene H M, Motyka, Marie, Mueller, Sebastian, Müller, Thoma, Nöthen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfützer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rösmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans-Ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, Jame, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, Pier Alberto, Tönjes, Anke, Werner, Lena, Werner, Jen, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mössner, Joachim, Férec, Claude, Michl, Patrick, P H Drenth, Joost, Witt, Heiko, Scholz, Marku, Sahin-Tóth, Miklós, and Gambaro, Giovanni (ORCID:0000-0001-5733-2370)
- Abstract
OBJECTIVE: Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus. DESIGN: 1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used. RESULTS: We replicated previously reported risk loci CLDN2-MORC4, CTRC, PRSS1-PRSS2 and SPINK1 in alcoholic CP patients. We identified CTRB1-CTRB2 (chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167 (OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2 locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956. The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk. CONCLUSION: An inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.
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- 2017
13. Migrantenunternehmer in Deutschland am Anfang des 2I.Jahrhunderts: Marktstrategien im Kontext ethnischer und individueller Ressourcen
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Leicht, René, primary and Werner, Lena, additional
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- 2013
- Full Text
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14. Genome-wide association study identifies inversion in the CTRB1-CTRB2locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
- Author
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Rosendahl, Jonas, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian-Min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algul, Hana, Buhler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, Giulia Martina, Cichoz-Lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grutzmann, Robert, Hellerbrand, Claus, Hegyi, Pééter, Hollenbach, Marcus, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lééévy, Philippe, Loffler, Markus, Lohr, Matthias, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka-Panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, te Morsche, Rene H M, Motyka, Marie, Mueller, Sebastian, Muller, Thomas, Nothen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfutzer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rosmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans-Ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, James, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, Pier Alberto, Tonjes, Anke, Werner, Lena, Werner, Jens, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mossner, Joachim, Féééérec, Claude, Michl, Patrick, P H Drenth, Joost, Witt, Heiko, Scholz, Markus, and Sahin-Tééééóóth, Miklééééós
- Abstract
ObjectiveAlcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.Design1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used.ResultsWe replicated previously reported risk loci CLDN2-MORC4, CTRC, PRSS1-PRSS2and SPINK1in alcoholic CP patients. We identified CTRB1-CTRB2(chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167(OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956. The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk.ConclusionAn inversion in the CTRB1-CTRB2locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.
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- 2018
- Full Text
- View/download PDF
15. The secondary transfer effect : the effect of friendship amongst adolescents on prejudice towards specific outgroups
- Author
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Werner, Lena and Werner, Lena
- Abstract
Previous research show that contact between outgroups can reduce prejudice and lead to positive intergroup relations. In this article, I study the secondary transfer effects (STEs) of outgroup friendship. More specifically, I study if intergroup friendship between native Swedes and specific ethnic outgroups is associated with STEs towards other specific ethnic outgroups. STE builds on the primary transfer effects (PTE) and occurs when the positive attitudes of intergroup contact are generalized to groups not included in the primary contact. Analyses rely on Swedish self-reported survey data from 2,831 high school students, aged 16-18. Five OLS regression analyses are used and results show that positive attitudes from friendship between individuals are generalized not only to the primary outgroup but also to secondary outgroups. However, STEs tend to be group-dependent and thus limited. STE is found to be present mainly when friendships cross perceived social distance and socially constructed group boundaries. In conclusion, STE differs between different ethnic outgroups and perceived social distance can help explain why.
16. The secondary transfer effect : the effect of friendship amongst adolescents on prejudice towards specific outgroups
- Author
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Werner, Lena and Werner, Lena
- Abstract
Previous research show that contact between outgroups can reduce prejudice and lead to positive intergroup relations. In this article, I study the secondary transfer effects (STEs) of outgroup friendship. More specifically, I study if intergroup friendship between native Swedes and specific ethnic outgroups is associated with STEs towards other specific ethnic outgroups. STE builds on the primary transfer effects (PTE) and occurs when the positive attitudes of intergroup contact are generalized to groups not included in the primary contact. Analyses rely on Swedish self-reported survey data from 2,831 high school students, aged 16-18. Five OLS regression analyses are used and results show that positive attitudes from friendship between individuals are generalized not only to the primary outgroup but also to secondary outgroups. However, STEs tend to be group-dependent and thus limited. STE is found to be present mainly when friendships cross perceived social distance and socially constructed group boundaries. In conclusion, STE differs between different ethnic outgroups and perceived social distance can help explain why.
17. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
- Author
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James R. A. Skipworth, Sebastian Krug, Florence Bühler, Sebastian Gimpfl, Joachim Mössner, Anke Tönjes, Atsushi Masamune, Adrian Saftoiu, Roland H. Pfützer, Marcella Rietschel, Heiko Witt, Felix Stickel, Jens Werner, Peter Kovacs, Nicole Soranzo, Constantin Zimmer, Martin Ziegler, Helmut Laumen, Holger Kirsten, Marco J. Bruno, Joost P.H. Drenth, Markus M. Lerch, Markus M. Nöthen, Claus Hellerbrand, Annette Peters, Philippe Lévy, Jian-Min Chen, Monika Ridinger, Giulia Martina Cavestro, Emmanuelle Masson, Milena Di Leo, Peter Simon, Peter Bugert, Péter Hegyi, Karl Mann, Miklós Sahin-Tóth, Pier Alberto Testoni, Núria Malats, Rene H. M. te Morsche, Konstantin Strauch, Stephen P. Pereira, Josef Frank, Norbert Wodarz, Halina Cichoż-Lach, Jonas Rosendahl, Alexander Schneider, Marcus Hollenbach, Olfert Landt, Markus Löffler, Sergio Pedrazzoli, Volker Keim, Matthias Löhr, Marie Motyka, Sebastian Mueller, Ralph Burkhardt, Antoni Farré, Heidi Griesmann, Falk Kiefer, Giovanni Malerba, Claudia Ruffert, Markus Scholz, Francisco X. Real, Maren Ludwig, Eszter Hegyi, Harald Grallert, Hana Algül, Vinciane Rebours, Eva Rösmann, Frank Ulrich Weiss, Sonja Mohr, Robert Grützmann, Sevastitia Iordache, Michael Soyka, Milan Macek, Peter Lichtner, Patrick Michl, Claude Férec, Giovanni Gambaro, Michael Stumvoll, Katharina Seltsam, Thomas Müller, Grazyna Jurkowska, Ewa Małecka-Panas, Sebastian Beer, Julia Mayerle, Hans-Ulrich Schulz, Lena Werner, Publica, Rosendahl, Jona, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algül, Hana, Bühler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, GIULIA MARTINA, Cichoz lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grützmann, Robert, Hellerbrand, Clau, Hegyi, Péter, Hollenbach, Marcu, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lévy, Philippe, Löffler, Marku, Löhr, Matthia, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, Te Morsche, Rene H. M, Motyka, Marie, Mueller, Sebastian, Müller, Thoma, Nöthen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfützer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rösmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, Jame, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, PIER ALBERTO, Tönjes, Anke, Werner, Lena, Werner, Jen, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mössner, Joachim, Férec, Claude, Michl, Patrick, Joost, P. H. Drenth, Witt, Heiko, Scholz, Marku, Sahin tóth, Miklós, and Gastroenterology & Hepatology
- Subjects
0301 basic medicine ,Linkage disequilibrium ,medicine.medical_specialty ,Settore MED/12 - GASTROENTEROLOGIA ,Population ,Genome Wide Association Study ,Chronic Pancreatitis ,Genetic Rearrangement ,Locus (genetics) ,Single-nucleotide polymorphism ,Genome-wide association study ,Biology ,Gastroenterology ,chronic pancreatitis ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,Internal medicine ,Genetic predisposition ,medicine ,Allele ,education ,Genetics ,education.field_of_study ,medicine.disease ,ddc ,genetic rearrangement ,Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,030104 developmental biology ,Genome wide association study ,Pancreatitis ,chronic pancreatiti ,Chronic pancreatitis ,Genetic rearrangement - Abstract
ObjectiveAlcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.Design1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used.ResultsWe replicated previously reported risk loci CLDN2-MORC4, CTRC, PRSS1-PRSS2 and SPINK1 in alcoholic CP patients. We identified CTRB1-CTRB2 (chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167 (OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2 locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956. The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk.ConclusionAn inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.
- Published
- 2018
18. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
- Author
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Rosendahl J, Kirsten H, Hegyi E, Kovacs P, Weiss FU, Laumen H, Lichtner P, Ruffert C, Chen JM, Masson E, Beer S, Zimmer C, Seltsam K, Algül H, Bühler F, Bruno MJ, Bugert P, Burkhardt R, Cavestro GM, Cichoz-Lach H, Farré A, Frank J, Gambaro G, Gimpfl S, Grallert H, Griesmann H, Grützmann R, Hellerbrand C, Hegyi P, Hollenbach M, Iordache S, Jurkowska G, Keim V, Kiefer F, Krug S, Landt O, Leo MD, Lerch MM, Lévy P, Löffler M, Löhr M, Ludwig M, Macek M, Malats N, Malecka-Panas E, Malerba G, Mann K, Mayerle J, Mohr S, Te Morsche RHM, Motyka M, Mueller S, Müller T, Nöthen MM, Pedrazzoli S, Pereira SP, Peters A, Pfützer R, Real FX, Rebours V, Ridinger M, Rietschel M, Rösmann E, Saftoiu A, Schneider A, Schulz HU, Soranzo N, Soyka M, Simon P, Skipworth J, Stickel F, Strauch K, Stumvoll M, Testoni PA, Tönjes A, Werner L, Werner J, Wodarz N, Ziegler M, Masamune A, Mössner J, Férec C, Michl P, P H Drenth J, Witt H, Scholz M, and Sahin-Tóth M
- Subjects
- Adult, Aged, Europe epidemiology, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Chymotrypsin genetics, Pancreatitis, Alcoholic epidemiology, Pancreatitis, Alcoholic genetics
- Abstract
Objective: Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus., Design: 1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used., Results: We replicated previously reported risk loci CLDN2-MORC4 , CTRC , PRSS1-PRSS2 and SPINK1 in alcoholic CP patients. We identified CTRB1-CTRB2 (chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167 (OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2 locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956 . The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk., Conclusion: An inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
- Published
- 2018
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