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2. Long-term clinical outcomes and cost-effectiveness of catheter vs thoracoscopic surgical ablation in long-standing persistent atrial fibrillation using continuous cardiac monitoring: CASA-AF randomized controlled trial

Author

Yahdev, Rashmi, Rahman-Halley, Shelley, Wong, Joyce, Opel, Aaisha, Kaba, Riyaz, Nyktari, Eva, Cambronero-Cortinas, Esther, Izgi, Cemil, Fairbairn, Timothy, Benton, Joanne, Chester, Ruth, Cunliffe, Eliane, Edmondson, Lucy, Gill, Matthew, Griffiths, Vicky, Harman, Rebecca, Huggett, Catherine, Keegan, Jenny, Kirby, Kevin, Lascelles, Karen, Manivarmane, Ramasamy, Munteanu, Iulia, O’Brien, Karen, Phyl, Tess, Rahneva, Tsveta, Riley, Cheryl, Rogers, Paula, Smith, Katherine, Wage, Rick, West, Cathy, Yakupoglu, Yakup, Yang, Guang, Audraite, Audra, Belchambers, Sandra, Hughes, Susan, Morgan, Maureen, Ronayne, Christina, Shaw, Rob, Simkus, Paulinus, Taylerson, Clive, Bruce, Chloe, McGregor, Andrew, Thomson, Catherine, Granville, Hollie, Snell, Alice, John, Sophia, Monteiro, Christiana, Augustine, Grace, Sutton, Nichola, Boyalla, Vennela, Haldar, Shouvik, Khan, Habib, Kralj-Hans, Ines, Banya, Winston, Lord, Joanne, Satishkumar, Anitha, Bahrami, Toufan, De Souza, Anthony, Clague, Jonathan R., Francis, Darrel P., Hussain, Wajid, Jarman, Julian W., Jones, David G., Chen, Zhong, Mediratta, Neeraj, Hyde, Jonathan, Lewis, Michael, Mohiaddin, Raad, Salukhe, Tushar V., Markides, Vias, McCready, James, Gupta, Dhiraj, and Wong, Tom

Published
2024
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7. Prognostic significance of subpulmonary left ventricular size and function in patients with a systemic right ventricle.

Author

Surkova, Elena, Constantine, Andrew, Xu, Zhuoyuan, Cal, Teresa Segura de la, Bispo, Daniela, West, Cathy, Senior, Roxy, Dimopoulos, Konstantinos, and Li, Wei

Subjects
HEART disease prognosis, LEFT heart ventricle, ECHOCARDIOGRAPHY, CAUSES of death, CONFIDENCE intervals, RIGHT heart ventricle, CARDIOPULMONARY system, DESCRIPTIVE statistics, RECEIVER operating characteristic curves, TRANSPLANTATION of organs, tissues, etc.
Abstract

Aims To assess the additional prognostic significance of echocardiographic parameters of subpulmonary left ventricular (LV) size and function in patients with a systemic right ventricle (SRV). Methods and results All adults with an SRV who underwent transthoracic echocardiography in 2010–18 at a large tertiary centre were identified. Biventricular size and function were assessed at the most recent examination. The study endpoint was all-cause mortality or heart/heart–lung transplantation. We included 180 patients, with 100 (55.6%) males, with a mean age of 42.4 ± 12.3 years, of whom 103 (57.2%) had undergone Mustard/Senning operations and 77 (42.8%) had congenitally corrected transposition of great arteries. Over 4.9 (3.8–5.7) years, 28 (15.6%) patients died and 4 (2.2%) underwent heart or heart–lung transplantation. Univariable predictors of the study endpoint included age, New York Heart Association functional Class III or IV, history of atrial arrhythmias, presence of a pacemaker or cardioverter defibrillator, high B-type natriuretic peptide, and echocardiographic markers of SRV and subpulmonary LV size and function. On multivariable Cox analysis of echocardiographic variables, indexed LV end-systolic diameter [ESDi; hazard ratio (HR) 2.77 (95% confidence interval, CI) 1.35–5.68, P = 0.01], LV fractional area change [FAC; HR 0.7 (95% CI 0.57–0.85), P = 0.002), SRV basal diameter [HR 1.66 (95% CI 1.21–2.29), P = 0.005], and SRV FAC [HR 0.65 (95% CI 0.49–0.87), P = 0.008] remained predictive of mortality or transplantation. On receiver-operating characteristic analysis, subpulmonary LV parameters performed better than SRV markers in predicting adverse events. Conclusion SRV basal diameter, SRV FAC, LV ESDi, and LV FAC are significantly and independently associated with mortality and transplantation in adults with an SRV. Accurate echocardiographic assessment of both SRV and subpulmonary LV is, therefore, essential to inform risk stratification and management. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Contraction patterns of the systemic right ventricle: a three-dimensional echocardiography study.

Author

Surkova, Elena, Kovács, Attila, Lakatos, Bálint Károly, Tokodi, Márton, Fábián, Alexandra, West, Cathy, Senior, Roxy, and Li, Wei

Subjects
CARDIAC surgery, ECHOCARDIOGRAPHY, TRANSPOSITION of great vessels, THREE-dimensional imaging, VENTRICULAR ejection fraction, RIGHT heart ventricle, CARDIAC contraction, POSTOPERATIVE period, DESCRIPTIVE statistics
Abstract

Aims To investigate contraction patterns of the systemic right ventricle (SRV) in patients with transposition of great arteries (TGA) post-atrial switch operation and with congenitally corrected transposition of great arteries (ccTGA). Methods and results Right ventricular (RV) volumes and ejection fraction (EF) were measured by three-dimensional echocardiography in 38 patients with the SRV (24 TGA and 14 ccTGA; mean age 45 ± 12 years, 63% male), and in 38 healthy volunteers. The RV contraction was decomposed along the longitudinal, radial, and anteroposterior directions providing longitudinal, radial, and anteroposterior EF (LEF, REF, and AEF, respectively) and their contributions to total right ventricular ejection fraction (LEFi, REFi, and AEFi, respectvely). SRV was significantly larger with lower systolic function compared with healthy controls. SRV EF and four-chamber longitudinal strain strongly correlated with B-type natriuretic peptide (BNP) level (Rho −0.73, P < 0.0001 and 0.70, P < 0.0001, respectively). In patients with TGA, anteroposterior component was significantly higher than longitudinal and radial components (AEF 17 ± 4.5% vs. REF 13 ± 4.9% vs. LEF 10 ± 3.3%, P < 0.0001; AEFi 0.48 ± 0.09 vs. REFi 0.38 ± 0.1 vs. LEFi 0.29 ± 0.08, P < 0.0001). In patients with ccTGA, there was no significant difference between three SRV components. AEFi was significantly higher in TGA subgroup compared with ccTGA (0.48 ± 0.09 vs. 0.36 ± 0.08, P = 0.0002). Conclusion Contraction patterns of the SRV are different in TGA and ccTGA. Anteroposterior component is dominant in TGA providing compensation for impaired longitudinal and radial components, while in ccTGA all components contribute equally to the total EF. SRV EF and longitudinal strain demonstrate strong correlation with BNP level and should be a part of routine echocardiographic assessment of the SRV. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Right ventricular dysfunction in critically ill COVID-19 ARDS

Author

Bleakley, Caroline, primary, Singh, Suveer, additional, Garfield, Benjamin, additional, Morosin, Marco, additional, Surkova, Elena, additional, Mandalia, Ms Sundhiya, additional, Dias, Bernardo, additional, Androulakis, Emmanouil, additional, Price, Laura C., additional, McCabe, Colm, additional, Wort, Stephen John, additional, West, Cathy, additional, Li, Wei, additional, Khattar, Rajdeep, additional, Senior, Roxy, additional, Patel, Brijesh V., additional, and Price, Susanna, additional

Published
2021
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19. Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial

Author

Mullen, Michael, primary, Jin, Xu Yu, additional, Child, Anne, additional, Stuart, A Graham, additional, Dodd, Matthew, additional, Aragon-Martin, José Antonio, additional, Gaze, David, additional, Kiotsekoglou, Anatoli, additional, Yuan, Li, additional, Hu, Jiangting, additional, Foley, Claire, additional, Van Dyck, Laura, additional, Knight, Rosemary, additional, Clayton, Tim, additional, Swan, Lorna, additional, Thomson, John D R, additional, Erdem, Guliz, additional, Crossman, David, additional, Flather, Marcus, additional, Dean, John, additional, Was, Bartosz, additional, Gow, Heather, additional, Murray, Jane, additional, D'Allessandro, Mariella, additional, Christie, Michael, additional, Cooper, Patricia, additional, Booth, Philip, additional, Burns, Sharon, additional, Paterson, Yvonne, additional, Chikermane, Ashish, additional, Assing, Anthony, additional, Cotter, Catherine, additional, Atkins, Gillian, additional, Williamson, Helen, additional, Barclay, Justin, additional, Jennison, Alan, additional, Henderson, Alex, additional, McSkeane, Anna, additional, Fairlamb, Helen, additional, Kelly, Julie, additional, Kelsall, Nicola, additional, Prentice, Scott, additional, O'Sullivan, John, additional, Head-Baister, Alison, additional, Phillipson, Angela, additional, Johnson, Anna, additional, Crossland, D, additional, Oliver, Jack, additional, Davison, Jade, additional, Wake, Jill, additional, Quinn, Louise, additional, Foreman, Maureen, additional, Wealleans, Vera, additional, Walker, Niki, additional, Duncan, Alexis, additional, Tibbs, Evelyn, additional, Kelly, Ruth, additional, Khambadkone, Sachin, additional, Zotti, Bridget, additional, Brady, Cassie, additional, Cervi, Elena, additional, Field, Ella, additional, Szepezvary, Eszter, additional, Mantey, Florence, additional, Riley, Gillian, additional, Titmus, Heather, additional, Bo, Ilaria, additional, Kaski, Juan Pablo, additional, Green, Loren, additional, Jones, Nigel, additional, Banks, Rebecca, additional, Kiesewetter, Christopher, additional, Mathur, Sujeev, additional, Frigiola, Alessandra, additional, Savis, Alex, additional, Belfield, Holly, additional, Guzman, Josephine, additional, Harris, Julia, additional, Wilson, Karen, additional, Peacock, Kelly, additional, Gibson, Kirsty, additional, Wellman, Paul, additional, Simpson, John, additional, Kabir, Saleha, additional, Mushemi, Sitali, additional, Stewart, Michael, additional, Atkinson, Bev, additional, Richardson, Cath, additional, Leng, Elaine, additional, Brennan, Paul, additional, Nixon, Annabel, additional, Spencer, Collette, additional, Oliver, James, additional, Forster, Jan, additional, Turner, Louise, additional, Bainbridge, Samantha, additional, Choy, Anna Maria, additional, Dawson, Adelle, additional, Kiddie, Gwen, additional, Kerr, Heather, additional, Mordi, Ify, additional, Duff, Jackie, additional, Dunlop, Jacqueline, additional, Berg, Jonathan, additional, Armory, Pauline, additional, Freeman, Leisa, additional, Anwar, Amir, additional, Graham, Charles, additional, London, Clare, additional, Healey, Gail, additional, Gallagher, Ian, additional, Ilsley, Mary, additional, Ahmed, Rizwan, additional, Wood, Sheila, additional, Wheeldon, Nigel, additional, Mason, Cecilia, additional, Nassim, Farook, additional, Middle, Janet, additional, Adams, Justin, additional, Angelini, Karen, additional, Housley, Kay, additional, Ryalls, Kim, additional, Agyemang, Michael, additional, Walker, Rachel, additional, Batigan, Robina, additional, Bennett, Tina, additional, Clift, Paul, additional, Alvior, Amor Mia, additional, Nilsson, Annette, additional, Green, Carole, additional, Crook, Charlotte, additional, Palmer, Connie Becani, additional, Dwenger, Elizabeth, additional, Doherty, Phillipa, additional, Igbokwe, Rebecca, additional, Sharif, Saba, additional, MacDonald, Sonia, additional, West, Cathy, additional, Kirby, Kevin, additional, Naqvi, Nitha, additional, Welch, Sophie, additional, Warsama, Suad, additional, Li, Wei, additional, Farzad, Zohreh, additional, Smith, Ben, additional, Murday, Victoria, additional, Murtagh, Eamonn, additional, Adams, Emma, additional, Armour, Lesley, additional, Lilley, Stuart, additional, Pandya, Bejal, additional, Richards, Amy, additional, Andiapen, Mervyn, additional, Macrae, Rebecca, additional, Tome, Maite, additional, Hutchinson, Carmel, additional, Angulo, Kameka, additional, Kauppayamootoo, Rooba, additional, Gati, Sabiha, additional, Cruddas, Elizabeth, additional, Newman, William G, additional, Breen, Catherine, additional, Kumar, Dhavendra, additional, Wilson, Dirk G, additional, Farrugia, Adele, additional, Fraser, Alan, additional, Sumers, Jayne, additional, Powell, Jessie, additional, Edwards, Julie, additional, Hale, Terese, additional, Boult, Zoe, additional, Carroll, Aisling, additional, Veldtman, Gruschen, additional, Ho, Andrew, additional, Black, David, additional, Fletcher, Lisa, additional, Mapstone, Sue, additional, Bharucha, Tara, additional, Marsh, Gary, additional, Jones, Joanne, additional, Sheehan, Karen, additional, Selway, Kathleen, additional, Stevenson, Kirsty, additional, Nelson, Martin, additional, Fairweather, Rebecca, additional, Curtis, Stephanie, additional, Simpson, Sue, additional, Denvir, Martin, additional, White, Audrey, additional, Steven, Jill, additional, Munro, Joanna, additional, Lam, Wayne, additional, Toff, William, additional, Petrou, Mario, additional, Silcocks, Paul, additional, and MacAllister, Raymond, additional

Published
2019
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23. Contemporary cardiac surgery for adults with congenital heart disease

Author

Beurtheret, Sylvain, primary, Tutarel, Oktay, additional, Diller, Gerhard Paul, additional, West, Cathy, additional, Ntalarizou, Evangelia, additional, Resseguier, Noémie, additional, Papaioannou, Vasileios, additional, Jabbour, Richard, additional, Simpkin, Victoria, additional, Bastin, Anthony J, additional, Babu-Narayan, Sonya V, additional, Bonello, Beatrice, additional, Li, Wei, additional, Sethia, ​Babulal, additional, Uemura, Hideki, additional, Gatzoulis, Michael A, additional, and Shore, Darryl, additional

Published
2017
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26. Mass Confusion

Author

Sehmi, Joban S., primary, West, Cathy, additional, Khattar, Rajdeep, additional, Senior, Roxy, additional, and Chahal, Navtej S., additional

Published
2015
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36. Adapted bread oven

Author

West, Cathy

Subjects
General interest, Hobbies and crafts, Home and garden
Abstract

I used the article on building a bread oven ('Backyard Bread Oven') from your November/ December 2008 issue and adapted it for Florida. Using the instructions for the base from [...]

Published
2009

37. Women who kill.

Author

West, Cathy Maynard

Subjects
Women Who Kill (Book) -- Book reviews, Books
Published
1980

40. Prognostic significance of subpulmonary left ventricular size and function in patients with a systemic right ventricle.

Author

Surkova E, Constantine A, Xu Z, Segura de la Cal T, Bispo D, West C, Senior R, Dimopoulos K, and Li W

Subjects
Adult, Male, Humans, Middle Aged, Female, Prognosis, Heart Ventricles diagnostic imaging, Congenitally Corrected Transposition of the Great Arteries complications, Echocardiography methods, Ventricular Function, Right, Transposition of Great Vessels surgery
Abstract

Aims: To assess the additional prognostic significance of echocardiographic parameters of subpulmonary left ventricular (LV) size and function in patients with a systemic right ventricle (SRV)., Methods and Results: All adults with an SRV who underwent transthoracic echocardiography in 2010-18 at a large tertiary centre were identified. Biventricular size and function were assessed at the most recent examination. The study endpoint was all-cause mortality or heart/heart-lung transplantation. We included 180 patients, with 100 (55.6%) males, with a mean age of 42.4 ± 12.3 years, of whom 103 (57.2%) had undergone Mustard/Senning operations and 77 (42.8%) had congenitally corrected transposition of great arteries. Over 4.9 (3.8-5.7) years, 28 (15.6%) patients died and 4 (2.2%) underwent heart or heart-lung transplantation. Univariable predictors of the study endpoint included age, New York Heart Association functional Class III or IV, history of atrial arrhythmias, presence of a pacemaker or cardioverter defibrillator, high B-type natriuretic peptide, and echocardiographic markers of SRV and subpulmonary LV size and function. On multivariable Cox analysis of echocardiographic variables, indexed LV end-systolic diameter [ESDi; hazard ratio (HR) 2.77 (95% confidence interval, CI) 1.35-5.68, P = 0.01], LV fractional area change [FAC; HR 0.7 (95% CI 0.57-0.85), P = 0.002), SRV basal diameter [HR 1.66 (95% CI 1.21-2.29), P = 0.005], and SRV FAC [HR 0.65 (95% CI 0.49-0.87), P = 0.008] remained predictive of mortality or transplantation. On receiver-operating characteristic analysis, subpulmonary LV parameters performed better than SRV markers in predicting adverse events., Conclusion: SRV basal diameter, SRV FAC, LV ESDi, and LV FAC are significantly and independently associated with mortality and transplantation in adults with an SRV. Accurate echocardiographic assessment of both SRV and subpulmonary LV is, therefore, essential to inform risk stratification and management., Competing Interests: Conflict of interest: E.S. has received personal fees from GE Healthcare and 123sonography. A.C. has received educational grants, personal fees, and non-financial support from Janssen-Cilag Limited. T.S.d.l.C. has received non-financial support from Janssen-Cilag Limited. K.D. has received non-financial support from Janssen-Cilag Limited; and has been a consultant to and received grants and personal fees from Janssen-Cilag Limited, Pfizer, GlaxoSmithKline, and Bayer/MSD. All of the remaining authors have no relationships with industry to declare., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2023
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41. Contraction patterns of the systemic right ventricle: a three-dimensional echocardiography study.

Author

Surkova E, Kovács A, Lakatos BK, Tokodi M, Fábián A, West C, Senior R, and Li W

Subjects
Humans, Male, Adult, Middle Aged, Female, Heart Ventricles diagnostic imaging, Ventricular Function, Right, Stroke Volume, Congenitally Corrected Transposition of the Great Arteries, Ventricular Dysfunction, Right diagnostic imaging, Transposition of Great Vessels diagnostic imaging, Transposition of Great Vessels surgery, Echocardiography, Three-Dimensional
Abstract

Aims: To investigate contraction patterns of the systemic right ventricle (SRV) in patients with transposition of great arteries (TGA) post-atrial switch operation and with congenitally corrected transposition of great arteries (ccTGA)., Methods and Results: Right ventricular (RV) volumes and ejection fraction (EF) were measured by three-dimensional echocardiography in 38 patients with the SRV (24 TGA and 14 ccTGA; mean age 45 ± 12 years, 63% male), and in 38 healthy volunteers. The RV contraction was decomposed along the longitudinal, radial, and anteroposterior directions providing longitudinal, radial, and anteroposterior EF (LEF, REF, and AEF, respectively) and their contributions to total right ventricular ejection fraction (LEFi, REFi, and AEFi, respectvely). SRV was significantly larger with lower systolic function compared with healthy controls. SRV EF and four-chamber longitudinal strain strongly correlated with B-type natriuretic peptide (BNP) level (Rho -0.73, P < 0.0001 and 0.70, P < 0.0001, respectively). In patients with TGA, anteroposterior component was significantly higher than longitudinal and radial components (AEF 17 ± 4.5% vs. REF 13 ± 4.9% vs. LEF 10 ± 3.3%, P < 0.0001; AEFi 0.48 ± 0.09 vs. REFi 0.38 ± 0.1 vs. LEFi 0.29 ± 0.08, P < 0.0001). In patients with ccTGA, there was no significant difference between three SRV components. AEFi was significantly higher in TGA subgroup compared with ccTGA (0.48 ± 0.09 vs. 0.36 ± 0.08, P = 0.0002)., Conclusion: Contraction patterns of the SRV are different in TGA and ccTGA. Anteroposterior component is dominant in TGA providing compensation for impaired longitudinal and radial components, while in ccTGA all components contribute equally to the total EF. SRV EF and longitudinal strain demonstrate strong correlation with BNP level and should be a part of routine echocardiographic assessment of the SRV., Competing Interests: Conflict of interest: A.K., B.K.L., M.T., and A.F. report personal consulting fees from Argus Cognitive, Inc. Other co-authors have nothing to disclose., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.)

Published
2022
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