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8. Surgical Decision-Making in Familial Adenomatous Polyposis.

Author

Steinberger, Allie E., Westfal, Maggie L., and Wise, Paul E.

Abstract

Familial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostomy. The operative options and extent of resection, as well as the use of endoscopy and chemoprevention for the management of polyposis, will be discussed in detail in this article. In addition, commonly debated management decisions related to the treatment of patients with FAP, including the timing of prophylactic colorectal resections for patients with FAP and management of the polyp burden in the rectum, will be discussed. Finally, genotype considerations and the impact of desmoid disease on operative decisions in the setting of FAP will also be reviewed. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Supplementary Methods, Figures 1-9, Tables 1-3 from Genomic Complexity and AKT Dependence in Serous Ovarian Cancer

Author

Hanrahan, Aphrothiti J., primary, Schultz, Nikolaus, primary, Westfal, Maggie L., primary, Sakr, Rita A., primary, Giri, Dilip D., primary, Scarperi, Stefano, primary, Janikariman, Manickam, primary, Olvera, Narciso, primary, Stevens, Ellen V., primary, She, Qing-Bai, primary, Aghajanian, Carol, primary, King, Tari A., primary, de Stanchina, Elisa, primary, Spriggs, David R., primary, Heguy, Adriana, primary, Taylor, Barry S., primary, Sander, Chris, primary, Rosen, Neal, primary, Levine, Douglas A., primary, and Solit, David B., primary

Published
2023
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17. Data from Genomic Complexity and AKT Dependence in Serous Ovarian Cancer

Author

Hanrahan, Aphrothiti J., primary, Schultz, Nikolaus, primary, Westfal, Maggie L., primary, Sakr, Rita A., primary, Giri, Dilip D., primary, Scarperi, Stefano, primary, Janikariman, Manickam, primary, Olvera, Narciso, primary, Stevens, Ellen V., primary, She, Qing-Bai, primary, Aghajanian, Carol, primary, King, Tari A., primary, de Stanchina, Elisa, primary, Spriggs, David R., primary, Heguy, Adriana, primary, Taylor, Barry S., primary, Sander, Chris, primary, Rosen, Neal, primary, Levine, Douglas A., primary, and Solit, David B., primary

Published
2023
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25. Civilian Firearm-related Injuries

Author

Hsu, Yu-Tien, primary, Chang, David C., additional, Perez, Numa P., additional, Westfal, Maggie L., additional, Kelleher, Cassandra M., additional, Sacks, Chana A., additional, and Masiakos, Peter T., additional

Published
2020
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28. Underemployment of Female Surgeons?.

Author

Ya-Wen Chen, Westfal, Maggie L., Chang, David C., and Kelleher, Cassandra M.

Abstract

Objective: To compare the complexity of operations performed by female versus male surgeons. Background: Prior literature has suggested that female surgeons are relatively underemployed when compared to male surgeons, with regards to operative case volume and specialization. Methods: Operative case records from a large academic medical center from 1997 to 2018 were evaluated. The primary end point was work relative value unit (wRVU) for each case with a secondary end point of total wRVU per month for each surgeon. Multivariate linear analysis was performed, adjusting for surgeon race, calendar year, seniority, and clinical subspecialty. Results: A total of 551,047 records were analyzed, from 131 surgeons and 13,666 surgeon-months. Among them, 104,424 (19.0%) of cases were performed by female surgeons, who make up 20.6% (n - 27) of the surgeon population, and 2879 (21.1%) of the surgeon months. On adjusted analysis, male surgeons earned an additional 1.65 wRVU per case, compared to female surgeons (95% confidence interval 1.57-1.74). Subset analyses found that sex disparity increased with surgeon seniority, and did not improve over the 20- year study period. Conclusions: Female surgeons perform less complex cases than their male peers, even after accounting for subspecialty and seniority. These sex differences are not due to availability from competing professional or familial obligations. Future work should focus on determining the cause and mitigating this underemployment of female surgeons. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Genomic Complexity and AKT Dependence in Serous Ovarian Cancer

Author

Hanrahan, Aphrothiti J., primary, Schultz, Nikolaus, additional, Westfal, Maggie L., additional, Sakr, Rita A., additional, Giri, Dilip D., additional, Scarperi, Stefano, additional, Janikariman, Manickam, additional, Olvera, Narciso, additional, Stevens, Ellen V., additional, She, Qing-Bai, additional, Aghajanian, Carol, additional, King, Tari A., additional, de Stanchina, Elisa, additional, Spriggs, David R., additional, Heguy, Adriana, additional, Taylor, Barry S., additional, Sander, Chris, additional, Rosen, Neal, additional, Levine, Douglas A., additional, and Solit, David B., additional

Published
2012
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