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210 results on '"Westra, Jelmer"'

1. Quantitative flow ratio versus fractional flow reserve for coronary revascularisation guidance (FAVOR III Europe): a multicentre, randomised, non-inferiority trial

Author

Andersen, Birgitte Krogsgaard, Sejr-Hansen, Martin, Maillard, Luc, Campo, Gianluca, Råmunddal, Truls, Stähli, Barbara E, Guiducci, Vincenzo, Serafino, Luigi Di, Escaned, Javier, Santos, Ignacio Amat, López-Palop, Ramón, Landmesser, Ulf, Dieu, Ruthe Storgaard, Mejía-Rentería, Hernán, Koltowski, Lukasz, Žiubrytė, Greta, Cetran, Laura, Adjedj, Julien, Abdelwahed, Youssef S, Liu, Tommy, Mogensen, Lone Juul Hune, Eftekhari, Ashkan, Westra, Jelmer, Lenk, Karsten, Casella, Gianni, Van Belle, Eric, Biscaglia, Simone, Olsen, Niels Thue, Knaapen, Paul, Kochman, Janusz, Santos, Ramón Calviño, Scarsini, Roberto, Christiansen, Evald Høj, and Holm, Niels Ramsing

Published
2024
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4. Myocardial Blood Flow by Magnetic Resonance in Patients With Suspected Coronary Stenosis: Comparison to PET and Invasive Physiology

Author

Rasmussen, Laust Dupont, Murphy, Theodore, Milidonis, Xenios, Eftekhari, Ashkan, Karim, Salma Raghad, Westra, Jelmer, Dahl, Jonathan Nørtoft, Isaksen, Christin, Brix, Lau, Ejlersen, June Anita, Nyegaard, Mette, Johansen, Jane Kirk, Søndergaard, Hanne Maare, Mortensen, Jesper, Gormsen, Lars Christian, Christiansen, Evald Høj, Chiribiri, Amedeo, Petersen, Steffen E., Bøttcher, Morten, and Winther, Simon

Published
2024
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6. Second-Line Myocardial Perfusion Imaging to Detect Obstructive Stenosis: Head-to-Head Comparison of CMR and PET

Author

Rasmussen, Laust Dupont, Winther, Simon, Eftekhari, Ashkan, Karim, Salma Raghad, Westra, Jelmer, Isaksen, Christin, Brix, Lau, Ejlersen, June Anita, Murphy, Theodore, Milidonis, Xenios, Nyegaard, Mette, Benovoy, Mitchel, Johansen, Jane Kirk, Søndergaard, Hanne Maare, Hammid, Osama, Mortensen, Jesper, Knudsen, Lars Lyhne, Gormsen, Lars Christian, Christiansen, Evald Høj, Chiribiri, Amedeo, Petersen, Steffen E., and Böttcher, Morten

Published
2023
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7. Microvascular resistance reserve: impact on health status and myocardial perfusion after revascularization in chronic coronary syndrome.

Author

Rasmussen, Laust Dupont, Westra, Jelmer, Karim, Salma Raghad, Dahl, Jonathan Nørtoft, Søby, Jacob Hartmann, Ejlersen, June Anita, Gormsen, Lars Christian, Eftekhari, Ashkan, Christiansen, Evald Høj, Bøttcher, Morten, and Winther, Simon

Subjects
POSITRON emission tomography, PROGNOSIS, CORONARY angiography, CHEST pain, ANGINA pectoris
Abstract

Background and Aims The microvascular resistance reserve (MRR) is a novel invasive index of the microcirculation, which is independent of epicardial stenoses, and has both diagnostic and prognostic implications. This study investigates whether MRR is associated with health status outcomes by revascularization in patients with moderate coronary stenoses. Methods Consecutive patients with stable chest pain and moderate (30%–90% diameter) stenoses on invasive coronary angiography (n = 222) underwent invasive physiology assessment. Revascularization was performed according to guideline recommendations. At baseline and follow-up, health status and myocardial perfusion were assessed by the Seattle Angina Questionnaire (SAQ) and positron emission tomography. The primary endpoint was freedom from angina at follow-up with secondary endpoints including changes in health status by SAQ domains and myocardial perfusion by MRR and revascularization status. Low MRR was defined as ≤3.0. Results Freedom from angina occurred in 38/173 patients. In multivariate analyses, MRR was associated with freedom from angina at follow-up (odds ratio 0.860, 95% confidence interval 0.740–0.987). By MRR and revascularization groups, patients with normal MRR who did not undergo revascularization, and patients with abnormal MRR who underwent revascularization, had improved health status of angina frequency [mean difference SAQ angina frequency score 8.5 (3.07–13.11) and 13.5 (2.82–23.16), respectively]. For both groups, health status of physical limitation [mean difference in SAQ physical limitation score 9.7 (4.79–11.93) and 8.7 (0.53–13.88), respectively] and general health status [mean difference in SAQ summary score 9.3 (5.18–12.50) and 10.8 (2.51–17.28), respectively] also improved. Only patients with abnormal MRR who underwent revascularization had improved myocardial perfusion. Conclusions In patients with moderate coronary stenoses, MRR seems to predict the symptomatic and perfusion benefit of revascularization. Clinical trial identifiers NCT03481712 and NCT04707859. [ABSTRACT FROM AUTHOR]

Published
2025
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13. Danish study of Non-Invasive testing in Coronary Artery Disease 2 (Dan-NICAD 2): Study design for a controlled study of diagnostic accuracy

Author

Rasmussen, Laust Dupont, Winther, Simon, Westra, Jelmer, Isaksen, Christin, Ejlersen, June Anita, Brix, Lau, Kirk, Jane, Urbonaviciene, Grazina, Søndergaard, Hanne Maare, Hammid, Osama, Schmidt, Samuel Emil, Knudsen, Lars Lyhne, Madsen, Lene Helleskov, Frost, Lars, Petersen, Steffen E., Gormsen, Lars Christian, Christiansen, Evald Høj, Eftekhari, Ashkan, Holm, Niels Ramsing, Nyegaard, Mette, Chiribiri, Amedeo, Bøtker, Hans Erik, and Böttcher, Morten

Published
2019
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14. Optimal diagnostic approach for using CT-derived quantitative flow ratio in patients with stenosis on coronary computed tomography angiography

Author

Dahl, Jonathan N., primary, Rasmussen, Laust D., additional, Ding, Daixin, additional, Tu, Shengxian, additional, Westra, Jelmer, additional, Wijns, William, additional, Christiansen, Evald, additional, Eftekhari, Ashkan, additional, Li, Guanyu, additional, Winther, Simon, additional, and Bøttcher, Morten, additional

Published
2024
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19. Danish study of Non-Invasive Testing in Coronary Artery Disease 3 (Dan-NICAD 3): study design of a controlled study on optimal diagnostic strategy

Author

Winther, Simon, primary, Dupont Rasmussen, Laust, additional, Westra, Jelmer, additional, Abdulzahra, Salma Raghad Karim, additional, Dahl, Jonathan Nørtoft, additional, Gormsen, Lars Christian, additional, Christiansen, Evald Høj, additional, Brix, Gitte Stokvad, additional, Mortensen, Jesper, additional, Ejlersen, June Anita, additional, Søndergaard, Hanne Maare, additional, Hansson, Nicolaj Christopher Lyng, additional, Holm, Niels Ramsing, additional, Knudsen, Lars Lyhne, additional, Eftekhari, Ashkan, additional, Møller, Peter L, additional, Rohde, Palle Duun, additional, Nyegaard, Mette, additional, and Böttcher, Morten, additional

Published
2023
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21. Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography: The International Multicenter FAVOR Pilot Study

Author

Tu, Shengxian, Westra, Jelmer, Yang, Junqing, von Birgelen, Clemens, Ferrara, Angela, Pellicano, Mariano, Nef, Holger, Tebaldi, Matteo, Murasato, Yoshinobu, Lansky, Alexandra, Barbato, Emanuele, van der Heijden, Liefke C., Reiber, Johan H.C., Holm, Niels R., and Wijns, William

Published
2016
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23. Instantaneous wave free ratio vs. fractional flow reserve and 5-year mortality:iFR SWEDEHEART and DEFINE FLAIR

Author

Eftekhari, Ashkan, Holck, Emil Nielsen, Westra, Jelmer, Olsen, Niels Thue, Bruun, Niels Henrik, Jensen, Lisette Okkels, Engstrøm, Thomas, Christiansen, Evald Høj, Eftekhari, Ashkan, Holck, Emil Nielsen, Westra, Jelmer, Olsen, Niels Thue, Bruun, Niels Henrik, Jensen, Lisette Okkels, Engstrøm, Thomas, and Christiansen, Evald Høj

Abstract

Background and Aims Guidelines recommend revascularization of intermediate epicardial artery stenosis to be guided by evidence of ischaemia. Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are equally recommended. Individual 5-year results of two major randomized trials comparing FFR with iFR-guided revascularization suggested increased all-cause mortality following iFR-guided revascularization. The aim of this study was a study-level meta-analysis of the 5-year outcome data in iFR-SWEDEHEART (NCT02166736) and DEFINE-FLAIR (NCT02053038). Methods Composite of major adverse cardiovascular events (MACE) and its individual components [all-cause death, myocardial infarction (MI), and unplanned revascularisation] were analysed. Raw Kaplan–Meier estimates, numbers at risk, and number of events were extracted at 5-year follow-up and analysed using the ipdfc package (Stata version 18, StataCorp, College Station, TX, USA). Results In total, iFR and FFR-guided revascularization was performed in 2254 and 2257 patients, respectively. Revascularization was more often deferred in the iFR group [n = 1128 (50.0%)] vs. the FFR group [n = 1021 (45.2%); P = .001]. In the iFR-guided group, the number of deaths, MACE, unplanned revascularization, and MI was 188 (8.3%), 484 (21.5%), 235 (10.4%), and 123 (5.5%) vs. 143 (6.3%), 420 (18.6%), 241 (10.7%), and 123 (5.4%) in the FFR group. Hazard ratio [95% confidence interval (CI)] estimates for MACE were 1.18 [1.04; 1.34], all-cause mortality 1.34 [1.08; 1.67], unplanned revascularization 0.99 [0.83; 1.19], and MI 1.02 [0.80; 1.32]. Conclusions Five-year all-cause mortality and MACE rates were increased with revascularization guided by iFR compared to FFR. Rates of unplanned revascularization and MI were equal in the two groups., Background and Guidelines recommend revascularization of intermediate epicardial artery stenosis to be guided by evidence of ischaemia. Aims Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are equally recommended. Individual 5-year results of two major randomized trials comparing FFR with iFR-guided revascularization suggested increased all-cause mortality following iFR-guided revascularization. The aim of this study was a study-level meta-analysis of the 5-year outcome data in iFR-SWEDEHEART (NCT02166736) and DEFINE-FLAIR (NCT02053038).Methods Composite of major adverse cardiovascular events (MACE) and its individual components [all-cause death, myocardial infarction (MI), and unplanned revascularisation] were analysed. Raw Kaplan–Meier estimates, numbers at risk, and number of events were extracted at 5-year follow-up and analysed using the ipdfc package (Stata version 18, StataCorp, College Station, TX, USA)Results In total, iFR and FFR-guided revascularization was performed in 2254 and 2257 patients, respectively. Revascularization was more often deferred in the iFR group [n = 1128 (50.0%)] vs. the FFR group [n = 1021 (45.2%); P = .001]. In the iFR-guided group, the number of deaths, MACE, unplanned revascularization, and MI was 188 (8.3%), 484 (21.5%), 235 (10.4%), and 123 (5.5%) vs. 143 (6.3%), 420 (18.6%), 241 (10.7%), and 123 (5.4%) in the FFR group. Hazard ratio [95% confidence interval (CI)] estimates for MACE were 1.18 [1.04; 1.34], all-cause mortality 1.34 [1.08; 1.67], unplanned revascularization 0.99 [0.83; 1.19], and MI 1.02 [0.80; 1.Conclusions Five-year all-cause mortality and MACE rates were increased with revascularization guided by iFR compared to FFR. Rates of unplanned revascularization and MI were equal in the two groups.

Published
2023

24. Interterritorial Variation in Myocardial Microcirculatory Function

Author

Nicolaisen, Jacob, Karim, Salma Raghad, Rasmussen, Laust Dupont, Winther, Simon, Bottcher, Morten, Eftekhari, Ashkan, Christiansen, Evald Hoj, Westra, Jelmer, Nicolaisen, Jacob, Karim, Salma Raghad, Rasmussen, Laust Dupont, Winther, Simon, Bottcher, Morten, Eftekhari, Ashkan, Christiansen, Evald Hoj, and Westra, Jelmer

Published
2023
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25. Instantaneous wave free ratio vs. fractional flow reserve and 5-year mortality: iFR SWEDEHEART and DEFINE FLAIR

Author

Eftekhari, Ashkan, Holck, Emil Nielsen, Westra, Jelmer, Olsen, Niels Thue, Bruun, Niels Henrik, Jensen, Lisette Okkels, Engstrom, Thomas, Christiansen, Evald Hoj, Eftekhari, Ashkan, Holck, Emil Nielsen, Westra, Jelmer, Olsen, Niels Thue, Bruun, Niels Henrik, Jensen, Lisette Okkels, Engstrom, Thomas, and Christiansen, Evald Hoj

Abstract

Background and Aims Guidelines recommend revascularization of intermediate epicardial artery stenosis to be guided by evidence of ischaemia. Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are equally recommended. Individual 5-year results of two major randomized trials comparing FFR with iFR-guided revascularization suggested increased all-cause mortality following iFR-guided revascularization. The aim of this study was a study-level meta-analysis of the 5-year outcome data in iFR-SWEDEHEART (NCT02166736) and DEFINE-FLAIR (NCT02053038).Methods Composite of major adverse cardiovascular events (MACE) and its individual components [all-cause death, myocardial infarction (MI), and unplanned revascularisation] were analysed. Raw Kaplan-Meier estimates, numbers at risk, and number of events were extracted at 5-year follow-up and analysed using the ipdfc package (Stata version 18, StataCorp, College Station, TX, USA).Results In total, iFR and FFR-guided revascularization was performed in 2254 and 2257 patients, respectively. Revascularization was more often deferred in the iFR group [n = 1128 (50.0%)] vs. the FFR group [n = 1021 (45.2%); P = .001]. In the iFR-guided group, the number of deaths, MACE, unplanned revascularization, and MI was 188 (8.3%), 484 (21.5%), 235 (10.4%), and 123 (5.5%) vs. 143 (6.3%), 420 (18.6%), 241 (10.7%), and 123 (5.4%) in the FFR group. Hazard ratio [95% confidence interval (CI)] estimates for MACE were 1.18 [1.04; 1.34], all-cause mortality 1.34 [1.08; 1.67], unplanned revascularization 0.99 [0.83; 1.19], and MI 1.02 [0.80; 1.32].Conclusions Five-year all-cause mortality and MACE rates were increased with revascularization guided by iFR compared to FFR. Rates of unplanned revascularization and MI were equal in the two groups. Structured Graphical Abstract Instantaneous wave-free ratio (iFR) is a non-hyperaemic pressure index measured in the wave-free period in diastole. Fractional flow reserve (FFR) is the ratio between, Funding Agencies|None.

Published
2023
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28. Likelihood reclassification by an acoustic-based score in suspected coronary artery disease

Author

Rasmussen, Laust Dupont, primary, Winther, Simon, additional, Karim, Salma Raghad, additional, Westra, Jelmer, additional, Kirk Johansen, Jane, additional, Søndergaard, Hanne Maare, additional, Hammid, Osama, additional, Sevestre, Emelyne, additional, Onuma, Yoshinobu, additional, Nyegaard, Mette, additional, Ejlersen, June Anita, additional, Høj Christiansen, Evald, additional, Eftekhari, Ashkan, additional, Holm, Niels Ramsing, additional, Schmidt, Samuel Emil, additional, and Bøttcher, Morten, additional

Published
2023
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30. Evaluation of Coronary Artery Stenosis by Quantitative Flow Ratio During Invasive Coronary Angiography: The WIFI II Study (Wire-Free Functional Imaging II)

Author

Westra, Jelmer, Tu, Shengxian, Winther, Simon, Nissen, Louise, Vestergaard, Mai-Britt, Andersen, Birgitte Krogsgaard, Holck, Emil Nielsen, Fox Maule, Camilla, Johansen, Jane Kirk, Andreasen, Lene Nyhus, Simonsen, Jo Krogsgaard, Zhang, Yimin, Kristensen, Steen Dalby, Maeng, Michael, Kaltoft, Anne, Terkelsen, Christian Juhl, Krusell, Lars Romer, Jakobsen, Lars, Reiber, Johan H.C., Lassen, Jens Flensted, Bøttcher, Morten, Bøtker, Hans Erik, Christiansen, Evald Høj, and Holm, Niels Ramsing

Published
2018
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31. Quantitative Flow Ratio Identifies Nonculprit Coronary Lesions Requiring Revascularization in Patients With ST-Segment–Elevation Myocardial Infarction and Multivessel Disease

Author

Spitaleri, Giosafat, Tebaldi, Matteo, Biscaglia, Simone, Westra, Jelmer, Brugaletta, Salvatore, Erriquez, Andrea, Passarini, Giulia, Brieda, Alessandro, Leone, Antonio Maria, Picchi, Andrea, Ielasi, Alfonso, Di Girolamo, Domenico, Trani, Carlo, Ferrari, Roberto, Reiber, Johan H.C., Valgimigli, Marco, Sabatè, Manel, and Campo, Gianluca

Published
2018
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33. Three-Dimensional Angiographic Characteristics versus Functional Stenosis Severity in Fractional and Coronary Flow Reserve Discordance: A DEFINE FLOW Sub Study

Author

Stegehuis, Valerie, primary, Westra, Jelmer, additional, Boerhout, Coen, additional, Sejr-Hansen, Martin, additional, Eftekhari, Ashkan, additional, Mejía-Renteria, Hernan, additional, Cambero-Madera, Maribel, additional, Van Royen, Niels, additional, Matsuo, Hitoshi, additional, Nakayama, Masafumi, additional, Siebes, Maria, additional, Christiansen, Evald Høj, additional, Van de Hoef, Tim, additional, and Piek, Jan, additional

Published
2022
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34. Three-Dimensional Angiographic Characteristics versus Functional Stenosis Severity in Fractional and Coronary Flow Reserve Discordance: A DEFINE FLOW Sub Study

Author

Stegehuis, Valerie E., Westra, Jelmer, Boerhout, C.K.M., Sejr-Hansen, Martin, Eftekhari, A., Mejia-Renteria, H., Royen, N. van, Hoef, T. van de, Piek, Jan J., Stegehuis, Valerie E., Westra, Jelmer, Boerhout, C.K.M., Sejr-Hansen, Martin, Eftekhari, A., Mejia-Renteria, H., Royen, N. van, Hoef, T. van de, and Piek, Jan J.

Abstract

Contains fulltext : 253392.pdf (Publisher’s version ) (Open Access)

Published
2022

37. Reproducibility of quantitative flow ratio: the QREP study

Author

Westra, Jelmer, primary, Sejr-Hansen, Martin, additional, Koltowski, Lukasz, additional, Mejía-Rentería, Hernán, additional, Tu, Shengxian, additional, Kochman, Janusz, additional, Zhang, Yimin, additional, Liu, Tommy, additional, Campo, Gianluca, additional, Hjort, Jakob, additional, Mogensen, Lone Juul Hune, additional, Erriquez, Andrea, additional, Andersen, Birgitte Krogsgaard, additional, Eftekhari, Ashkan, additional, Escaned, Javier, additional, Christiansen, Evald Christiansen, additional, and Holm, Niels Holm, additional

Published
2022
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38. One-step anatomic and function testing by cardiac CT versus second-line functional testing in symptomatic patients with coronary artery stenosis: head-to-head comparison of CT-derived fractional flow reserve and myocardial perfusion imaging

Author

Westra, Jelmer, primary, Li, Zehang, additional, Rasmussen, Laust Dupont, additional, Winther, Simon, additional, Li, Guanyu, additional, Nissen, Louise, additional, Petersen, Steffen E., additional, Ejlersen, June Anita, additional, Isaksen, Christin, additional, Gormsen, Lars Christian, additional, Urbonaviciene, Grazina, additional, Eftekhari, Ashkan, additional, Weng, Tingwen, additional, Qu, Xinkai, additional, Bøtker, Hans Erik, additional, Christiansen, Evald Høj, additional, Holm, Niels Ramsing, additional, Bøttcher, Morten, additional, and Tu, Shengxian, additional

Published
2021
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39. Polygenic Risk Score–Enhanced Risk Stratification of Coronary Artery Disease in Patients With Stable Chest Pain

Author

Christiansen, Morten Krogh, primary, Winther, Simon, additional, Nissen, Louise, additional, Vilhjálmsson, Bjarni Jóhann, additional, Frost, Lars, additional, Johansen, Jane Kirk, additional, Møller, Peter Loof, additional, Schmidt, Samuel Emil, additional, Westra, Jelmer, additional, Holm, Niels Ramsing, additional, Jensen, Henrik Kjærulf, additional, Christiansen, Evald Høj, additional, Guðbjartsson, Daníel Fannar, additional, Hólm, Hilma, additional, Stefánsson, Kári, additional, Bøtker, Hans Erik, additional, Bøttcher, Morten, additional, and Nyegaard, Mette, additional

Published
2021
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43. Advanced heart sound analysis as a new prognostic marker in stable coronary artery disease

Author

Winther, Simon, primary, Nissen, Louise, additional, Schmidt, Samuel Emil, additional, Westra, Jelmer, additional, Andersen, Ina Trolle, additional, Nyegaard, Mette, additional, Madsen, Lene Helleskov, additional, Knudsen, Lars Lyhne, additional, Urbonaviciene, Grazina, additional, Larsen, Bjarke Skogstad, additional, Struijk, Johannes Jan, additional, Frost, Lars, additional, Holm, Niels Ramsing, additional, Christiansen, Evald Høj, additional, Bøtker, Hans Erik, additional, and Bøttcher, Morten, additional

Published
2021
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44. Performance of quantitative flow ratio in patients with aortic stenosis undergoing transcatheter aortic valve implantation

Author

Sejr‐Hansen, Martin, primary, Christiansen, Evald Høj, additional, Ahmad, Yousif, additional, Vendrik, Jeroen, additional, Westra, Jelmer, additional, Holm, Niels R., additional, Thim, Troels, additional, Seligman, Henry, additional, Hall, Kerry, additional, Sen, Sayan, additional, Terkelsen, Christian Juhl, additional, and Eftekhari, Ashkan, additional

Published
2021
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48. Resting distal to aortic pressure ratio and fractional flow reserve discordance affects the diagnostic performance of quantitative flow ratio: Results from an individual patient data meta‐analysis

Author

Westra, Jelmer, primary, Eftekhari, Ashkan, additional, Tu, Shengxian, additional, Campo, Gianluca, additional, Escaned, Javier, additional, Winther, Simon, additional, Matsuo, Hitoshi, additional, Qu, Xinkai, additional, Koltowski, Lukasz, additional, Chang, Yunxiao, additional, Liu, Tommy, additional, Yang, Junqing, additional, Andersen, Birgitte Krogsgaard, additional, Wijns, William, additional, Böttcher, Morten, additional, Christiansen, Evald Høj, additional, Xu, Bo, additional, and Holm, Niels Ramsing, additional

Published
2020
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