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17 results on '"Whaley, Andrei K."'

3. New benzoquinone pigments from the hydnoid fungus Sarcodontia setosa and their biosynthetic relationship.

Author

Whaley, Andrei K., Ponkratova, Anastasiia O., Orlova, Anastasia A., Volobuev, Sergey V., Shakhova, Natalia V., Serebryakov, Evgeny B., Smirnov, Sergey N., Pustovit, Natalia V., Kraeva, Liudmila A., and Luzhanin, Vladimir G.

Subjects
BENZOQUINONES, PIGMENTS, ACID derivatives, ANTIBACTERIAL agents, FUNGI
Abstract

Chemical investigation of the hydnoid fungus Sarcodontia setosa resulted in the isolation of five compounds, including two new sarcodontic acid derivatives – setosic acid (1) and 7,8-dehydrohomosarcodontic acid (2) along with three known benzoquinone pigments – sarcodontic acid (3), 4,5-dehydrosarcodontic acid (4) and dihydrosarcodontic acid (5). The structures were elucidated using spectroscopic methods (UV, NMR and HR-ESIMS). The biosynthetic relationship of the isolated compounds is proposed and discussed. Antibacterial activity screening of compounds 1–5 against ESKAPE bacterial strains in vitro with zones of inhibition was performed and MIC values were established for the most active compounds (3 and 5). [ABSTRACT FROM AUTHOR]

Published
2024
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4. The standardization of officinal medicinal plants used in the Eurasian Economic Union: comparison with other pharmacopoeias

Author

Whaley, Anastasiia O., primary, Whaley, Andrei K., additional, Kovaleva, Elena L., additional, Frolova, Larisa N., additional, Orlova, Anastasia A., additional, Luzhanin, Vladimir G., additional, Flisyuk, Elena V., additional, Shigarova, Larisa V., additional, Pozharitskaya, Olga N., additional, and Shikov, Alexander N., additional

Published
2023
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8. The Ability of Acid-Based Natural Deep Eutectic Solvents to Co-Extract Elements from the Roots of Glycyrrhiza glabra L. and Associated Health Risks

Author

Shikov, Alexander N., primary, Shikova, Veronika A., additional, Whaley, Anastasiia O., additional, Burakova, Marina A., additional, Flisyuk, Elena V., additional, Whaley, Andrei K., additional, Terninko, Inna I., additional, Generalova, Yulia E., additional, Gravel, Irina V., additional, and Pozharitskaya, Olga N., additional

Published
2022
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10. Analysis of Empetrum nigrumL. lipophilic secondary metabolites, their metabolomic profiles and antioxidant activity

Author

Whaley, Andrei K., Minakov, Dmitriy A., Orlova, Anastasia A., Ponkratova, Anastasiia O., Fock, Ekaterina, Rukoyatkina, Natalia, Gambaryan, Stepan, and Luzhanin, Vladimir G.

Abstract

ABSTRACTFourteen hexane-soluble polyphenolic secondary metabolites were previously isolated as individual compounds from Empetrum nigrumL. and identified as three bibenzyls, four 9,10-dihydrophenanthrenes, two chalcones, four dihydrochalcones and one flavanone. In this study, the mass-spectra and retention indexes (RI) of compounds 1-14without prior derivatization were obtained and the resulting fragmentation pathways rationalized in accordance with literary data and the compounds structures. Preliminary differences in metabolite composition were assessed by comparative profiling using GC-MS chromatography combined with multivariate data analysis for a limited amount of E. nigrumn-hexane extracts obtained from plants growing in three different geographic locations. To characterize antioxidant capacity of isolated compounds 1-14we used our well-established model based on reactive oxygen species (ROS) production by activated human platelets and showed that most of the examined polyphenols act as antioxidants by inhibition of ROS production.

Published
2023
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13. New cyclic diarylheptanoids from the false heartwood of Betula pubescens Ehrh.

Author

Ponkratova, Anastasiia O., Vedernikov, Dmitry N., Whaley, Andrei K., Kuncova, Maria N., Smirnov, Sergey N., Serebryakov, Evgeny B., Spiridonova, Daria V., and Luzhanin, Vladimir G.

Subjects
HEARTWOOD, BIRCH, CUTIBACTERIUM acnes, CANDIDA albicans, KLEBSIELLA pneumoniae
Abstract

Two undescribed (1–2) and five known cyclic diarylheptanoids (3–7) were isolated from the false heartwood of white birch (Betula pubescens Ehrh.). All structures were elucidated through extensive 1D and 2D NMR experiments and HR-ESI-MS data, along with comparison of their spectroscopic data with those reported in the literature. The two new cyclic diarylheptanoids are betuladiol (1) and betulondiol (2). Extracts from false heartwood were evaluated for their antimicrobial activity against Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Staphylococcus aureus and Cutibacterium acnes together with their antifungal activity against Candida albicans and Candida glabrata. [ABSTRACT FROM AUTHOR]

Published
2022
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14. A new dimethoxy dihydrochalcone isolated from the shoots of Empetrum nigrum L.

Author

Ponkratova, Anastasiia O., Whaley, Andrei K., Orlova, Anastasia A., Smirnov, Sergey N., Serebryakov, Evgeny B., Proksch, Peter, and Luzhanin, Vladimir G.

Subjects
METABOLITES, ETHANES
Abstract

A new dihydrochalcone, 2',4'-dimethoxydihydrochalcone (1), together with 7 known compounds, 2',4'-dihydroxydihydrochalcone (2), 2'-hydroxy-4'-methoxydihydrochalcone (3), 2'-hydroxy-4'-methoxychalcone (4), 1-(3,5-dihydroxy-4-methoxyphenyl)-2-(3-hydroxyphenyl) ethane (5), 2,3,4,7-tetramethoxy-9,10-dihydrophenanthrene (6), 5-hydroxy-2,3,4-trimethoxy-9,10-dihydrophenanthrene (7) and 5,7-dihydroxy-6,8-dimethyl flavanone (8) were isolated from the shoots of Empetrum nigrum L. The structures of these compounds were elucidated using 1D and 2D NMR experiments along with HR-ESI-MS. Compound 6 is reported for the genus Empetrum for the first time. [ABSTRACT FROM AUTHOR]

Published
2022
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