1. Characterization of Adult and Neonatal Articular Cartilage From the Equine Stifle
- Author
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White, Jamie L, Salinas, Evelia Y, Link, Jarrett M, Hu, Jerry C, and Athanasiou, Kyriacos A
- Subjects
Veterinary Sciences ,Agricultural ,Veterinary and Food Sciences ,Arthritis ,Musculoskeletal ,Animals ,Cartilage ,Articular ,Femur ,Glycosaminoglycans ,Horses ,Infant ,Newborn ,Knee Joint ,Stifle ,Equine stifle joint ,Equine femoropatellar joint ,Cartilage characterization ,Cartilage tissue engineering ,Cartilage mechanical properties ,Veterinary sciences ,Zoology - Abstract
A significant portion of equine lameness is localized to the stifle joint. Effective cartilage repair strategies are largely lacking, however, recent advances in surgical techniques, biomaterials, and cellular therapeutics have broadened the clinical strategies of cartilage repair. To date, no studies have been performed directly comparing neonatal and adult articular cartilage from the stifle across multiple sites. An understanding of the differences in properties between the therapeutic target cartilage (i.e., adult cartilage) as well as potential donor cartilage (i.e., neonatal cartilage) could aid in selection of optimal harvest sites within a donor joint as well as evaluation of the success of the grafted cells or tissues within the host. Given the dearth of characterization studies of the equine stifle joint, and in particular neonatal stifle cartilage, the goal of this study was to measure properties of both potential source tissue and host tissue. Articular cartilage of the distal femur and patella (P) was assessed in regards to two specific factors, age of the animal and specific site within the joint. Two age groups were considered: neonatal (
- Published
- 2021