13 results on '"Whitehead Z"'
Search Results
2. Activity and safety of ipatasertib (ipat) for AKT activating mutation and/ or PTEN loss/loss of function solid tumors from MyTACTIC
- Author
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VanderWalde, A., primary, Spigel, D.R., additional, Darbonne, W.C., additional, Yu, W., additional, Kim, Y., additional, Whitehead, Z., additional, Szado, T., additional, Slater, D., additional, Zuniga, R., additional, and Arrowsmith, E., additional
- Published
- 2022
- Full Text
- View/download PDF
3. Serum anti‐GM2 and anti‐GalNAc‐GD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis
- Author
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Halstead, S. K., primary, Gourlay, D. S., additional, Penderis, J., additional, Bianchi, E., additional, Dondi, M., additional, Wessmann, A., additional, Musteata, M., additional, Le Chevoir, M., additional, Martinez‐Anton, L., additional, Bhatti, S. F. M., additional, Volk, H., additional, Mateo, I., additional, Tipold, A., additional, Ives, E., additional, Pakozdy, A., additional, Gutierrez‐Quintana, R., additional, Brocal, J., additional, Whitehead, Z., additional, Granger, N., additional, Pazzi, P., additional, Harcourt‐Brown, T., additional, José‐López, R., additional, Rupp, S., additional, Schenk, H. C., additional, Smith, P., additional, Gandini, G., additional, Menchetti, M., additional, Mortera‐Balsa, V., additional, Rusbridge, C., additional, Tauro, A., additional, Cozzi, F., additional, Deutschland, M., additional, Tirrito, F., additional, Freeman, P., additional, Lowrie, M., additional, Jackson, M. R., additional, Willison, H. J., additional, and Rupp, A., additional
- Published
- 2021
- Full Text
- View/download PDF
4. Management of solid waste by households at Nkayi growth point in Zimbabwe
- Author
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Witness Dlamini and Whitehead Zikhali
- Subjects
Recycling ,Reusing ,Circular economy ,Waste management ,Solid waste ,Environmental technology. Sanitary engineering ,TD1-1066 ,Standardization. Simplification. Waste ,HD62 - Abstract
Solid waste management is a serious public and environmental health concern in Zimbabwe, particularly in urban areas and growth points. The situation is exacerbated by the strategies to manage solid waste that are either ineffective or absent. This leads to dumping of solid waste in open spaces. This paper assessed the household’s solid waste management practices and the feasibility of a transition towards a circular economy at Nkayi growth point. The study adopted a concurrent mixed method study design. Semi-structured questionnaires and interviews were used to collect data from the respondents. Majority of the respondents (86.06 %) did not practice waste segregation whereas (13.94 %) did segregate their household waste. Most respondents (56.97 %) highlighted that they reused materials while 43.03 % did not. 58.79 % did not practice recycling of items such as plastics while 68 (41.21 %) practiced recycling. Most participants (59.39 %) perceived household waste management to be a responsibility of the local authority while least respondents (6.67 %) perceived it to be a responsibility of the household occupants. Most respondents (62.21 %) perceived segregation and recycling of household solid waste to be time consuming while the remaining respondents (38.79 %) perceived it not to be time consuming. Transition to a circular economy at Nkayi growth point is unlikely due to absence of local bylaws to enforce implementation of circular economy, lack of awareness by households on circular economy. The study recommends that the local authority provide waste separation receptacles to households, invest in educational and awareness and come up with bylaws to promote circular economy practices at Nkayi growth point.
- Published
- 2024
- Full Text
- View/download PDF
5. Serum anti‐GM2 and anti‐GalNAc‐GD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis.
- Author
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Halstead, S. K., Gourlay, D. S., Penderis, J., Bianchi, E., Dondi, M., Wessmann, A., Musteata, M., Le Chevoir, M., Martinez‐Anton, L., Bhatti, S. F. M., Volk, H., Mateo, I., Tipold, A., Ives, E., Pakozdy, A., Gutierrez‐Quintana, R., Brocal, J., Whitehead, Z., Granger, N., and Pazzi, P.
- Subjects
GUILLAIN-Barre syndrome ,IMMUNOGLOBULIN G ,IMMUNOGLOBULINS ,NEUROMUSCULAR diseases ,CRANIAL nerves - Abstract
Objectives: A previous single‐country pilot study indicated serum anti‐GM2 and anti‐GA1 anti‐glycolipid antibodies as potential biomarkers for acute canine polyradiculoneuritis. This study aims to validate these findings in a large geographically heterogenous cohort. Materials and Methods: Sera from 175 dogs clinically diagnosed with acute canine polyradiculoneuritis, 112 dogs with other peripheral nerve, cranial nerve or neuromuscular disorders and 226 neurologically normal dogs were screened for anti‐glycolipid antibodies against 11 common glycolipid targets to determine the immunoglobulin G anti‐glycolipid antibodies with the highest combined sensitivity and specificity for acute canine polyradiculoneuritis. Results: Anti‐GM2 anti‐glycolipid antibodies reached the highest combined sensitivity and specificity (sensitivity: 65.1%, 95% confidence interval 57.6 to 72.2%; specificity: 90.2%, 95% confidence interval 83.1 to 95.0%), followed by anti‐GalNAc‐GD1a anti‐glycolipid antibodies (sensitivity: 61.7%, 95% confidence interval 54.1 to 68.9%; specificity: 89.3%, 95% confidence interval 82.0 to 94.3%) and these anti‐glycolipid antibodies were frequently present concomitantly. Anti‐GA1 anti‐glycolipid antibodies were detected in both acute canine polyradiculoneuritis and control animals. Both for anti‐GM2 and anti‐GalNAc‐GD1a anti‐glycolipid antibodies, sex was found a significantly associated factor with a female to male odds ratio of 2.55 (1.27 to 5.31) and 3.00 (1.22 to 7.89), respectively. Anti‐GalNAc‐GD1a anti‐glycolipid antibodies were more commonly observed in dogs unable to walk (OR 4.56, 1.56 to 14.87). Clinical Significance: Anti‐GM2 and anti‐GalNAc‐GD1a immunoglobulin G anti‐glycolipid antibodies represent serum biomarkers for acute canine polyradiculoneuritis. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
6. Plasma nitrate/nitrite concentrations in dogs with naturally developing sepsis and non-infectious forms of the systemic inflammatory response syndrome
- Author
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Osterbur, K., Whitehead, Z., Sharp, C. R., and DeClue, A. E.
- Published
- 2011
- Full Text
- View/download PDF
7. 198 (PB078) - Activity and safety of ipatasertib (ipat) for AKT activating mutation and/ or PTEN loss/loss of function solid tumors from MyTACTIC
- Author
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VanderWalde, A., Spigel, D.R., Darbonne, W.C., Yu, W., Kim, Y., Whitehead, Z., Szado, T., Slater, D., Zuniga, R., and Arrowsmith, E.
- Published
- 2022
- Full Text
- View/download PDF
8. Prevalence of Salmonella in juvenile dogs affected with parvoviral enteritis
- Author
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Botha, W.J., Schoeman, J.P., Marks, S.L., Whitehead, Z., Annandale, C.H., Botha, W.J., Schoeman, J.P., Marks, S.L., Whitehead, Z., and Annandale, C.H.
- Abstract
Salmonellosis is a disease of major zoonotic importance and canine parvovirus is a potentially fatal cause of canine enteritis with a world-wide distribution. Persistent isolation of Salmonella during routine environmental sampling surveys of a hospital ward, reserved for the treatment of dogs with canine parvovirus infection, prompted investigation into a possible source. We hypothesised that dogs affected by canine parvovirus would have a higher prevalence of faecal salmonellae compared to an apparently healthy cohort. Seventy-four client-owned dogs naturally infected with canine parvovirus and 42 apparently healthy client-owned dogs were included in the study. This prospective, longitudinal, observational study was conducted over an 18-month period. Fresh faecal samples were collected from dogs aged 6 weeks to 9 months diagnosed with canine parvovirus infection and admitted for treatment, and from apparently healthy dogs presented for vaccination or routine hospital procedures. Faeces were submitted for the isolation, antimicrobial susceptibility testing and serotyping of salmonellae. The prevalence of faecal Salmonella shedding was 22% and 31% for the affected and apparently healthy dogs, respectively, which was not statistically different. No significant associations between Salmonella status and possible risk factors or continuous variables such as age, body weight and duration of hospitalisation were identified. All the Salmonella isolates (n = 32) were resistant to penicillin G, lincomycin and tylosin. Salmonellae from nine different serotypes were identified. The prevalence of Salmonella shedding in both groups was higher than that commonly reported, yet similar to those in previous reports on young dogs, shelter dogs or dogs fed a raw meat diet.
- Published
- 2018
9. Community Policing And Crime Prevention: Evaluating The Role Of Traditional Leaders Under Chief Madliwa In Nkayi District, Zimbabwe
- Author
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Whitehead Zikhali
- Subjects
community policing ,crime awareness ,crime prevention ,mobilsation ,traditional leaders ,Social Sciences ,Social pathology. Social and public welfare. Criminology ,HV1-9960 - Abstract
Community policing is a strategic consideration for contemporary policing, especially when police organisations worldwide increasingly seek cost-effective and sustainable methods of combating crime. The principle of community policing recognises the community and its leaders as equal partners in the prevention and reduction of crime. Hence, there is a need for research to interrogate how different police organisations have considered community policing as a panacea to their policing challenges. This study sought to evaluate the role of traditional leaders in community policing and crime prevention in the community of Chief Madliwa, Nkayi District in Matabeleland North Province of Zimbabwe. Interviews were carried out with eight village heads, four headmen and three key informants. Four focus group discussions were conducted to collect the villagers’ insight on the role of traditional leaders in community policing and crime prevention. Participants were identified using purposive and convenience sampling. The findings revealed that community policing is an effective strategy for crime prevention and that traditional leaders play a pivotal role in the success of community policing and crime prevention. Traditional leaders play an integral role in the recruitment of members of the Neighbourhood Watch Committee, assist with organising the business community to cooperate with the police in the fight against crime and play an important role in organising the community to attend crime awareness campaigns arranged by the police.
- Published
- 2019
- Full Text
- View/download PDF
10. Serum anti-GM2 and anti-GalNAc-GD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis
- Author
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Dawn Gourlay, S. Rupp, Paul Freeman, M. R. Jackson, H. C. Schenk, Annette Wessmann, Akos Pakozdy, P. Pazzi, S. K. Halstead, Peter K. Smith, Hugh J. Willison, Ezio Bianchi, Nicolas Granger, Gualtiero Gandini, F. Tirrito, Thomas R Harcourt-Brown, Sofie Bhatti, F. Cozzi, Marco Menchetti, Rodrigo Gutierrez-Quintana, Jacques Penderis, M. Le Chevoir, V. Mortera-Balsa, Angie Rupp, A. Tauro, Mark Lowrie, Josep Brocal, Edward Ives, Andrea Tipold, Holger A. Volk, Maurizio Dondi, L. Martinez-Anton, I. Mateo, Mihai Musteata, M. Deutschland, Clare Rusbridge, Roberto José-López, Z. Whitehead, Halstead S.K., Gourlay D.S., Penderis J., Bianchi E., Dondi M., Wessmann A., Musteata M., Le Chevoir M., Martinez-Anton L., Bhatti S.F.M., Volk H., Mateo I., Tipold A., Ives E., Pakozdy A., Gutierrez-Quintana R., Brocal J., Whitehead Z., Granger N., Pazzi P., Harcourt-Brown T., Jose-Lopez R., Rupp S., Schenk H.C., Smith P., Gandini G., Menchetti M., Mortera-Balsa V., Rusbridge C., Tauro A., Cozzi F., Deutschland M., Tirrito F., Freeman P., Lowrie M., Jackson M.R., Willison H.J., and Rupp A.
- Subjects
Male ,medicine.medical_specialty ,Polyradiculoneuropathy ,G(M2) Ganglioside ,Pilot Projects ,Dog, canine, Polyradiculoneuritis ,Gastroenterology ,Immunoglobulin G ,Canine polyradiculoneuritis ,GalNAc-GD1a ,Dogs ,Internal medicine ,medicine ,Animals ,Humans ,Clinical significance ,Dog Diseases ,Small Animals ,biology ,business.industry ,Odds ratio ,Confidence interval ,carbohydrates (lipids) ,Cohort ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Female ,Antibody ,business ,Biomarkers - Abstract
Objectives: \ud A previous single-country pilot study indicated serum anti-GM2 and anti-GA1 anti-glycolipid antibodies as potential biomarkers for acute canine polyradiculoneuritis. This study aims to validate these findings in a large geographically heterogenous cohort.\ud \ud Materials and Methods: \ud Sera from 175 dogs clinically diagnosed with acute canine polyradiculoneuritis, 112 dogs with other peripheral nerve, cranial nerve or neuromuscular disorders and 226 neurologically normal dogs were screened for anti-glycolipid antibodies against 11 common glycolipid targets to determine the immunoglobulin G anti-glycolipid antibodies with the highest combined sensitivity and specificity for acute canine polyradiculoneuritis.\ud \ud Results: \ud Anti-GM2 anti-glycolipid antibodies reached the highest combined sensitivity and specificity (sensitivity: 65.1%, 95% confidence interval 57.6 to 72.2%; specificity: 90.2%, 95% confidence interval 83.1 to 95.0%), followed by anti-GalNAc-GD1a anti-glycolipid antibodies (sensitivity: 61.7%, 95% confidence interval 54.1 to 68.9%; specificity: 89.3%, 95% confidence interval 82.0 to 94.3%) and these anti-glycolipid antibodies were frequently present concomitantly. Anti-GA1 anti-glycolipid antibodies were detected in both acute canine polyradiculoneuritis and control animals. Both for anti-GM2 and anti-GalNAc-GD1a anti-glycolipid antibodies, sex was found a significantly associated factor with a female to male odds ratio of 2.55 (P=0.0096) and 3.00 (P=0.0198), respectively. Anti-GalNAc-GD1a anti-glycolipid antibodies were more commonly observed in dogs unable to walk (odds ratio 4.56; P=0.0076).\ud \ud Clinical Significance: \ud Anti-GM2 and anti-GalNAc-GD1a immunoglobulin G anti-glycolipid antibodies represent serum biomarkers for acute canine polyradiculoneuritis.
- Published
- 2021
11. Haemostatic changes associated with fluid resuscitation in canine parvoviral enteritis.
- Author
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Whitehead Z, Goddard A, Botha WJ, and Pazzi P
- Subjects
- Animals, Crystalloid Solutions therapeutic use, Dogs, Enteritis therapy, Female, Male, Parvoviridae Infections therapy, Parvovirus, Canine physiology, Prospective Studies, Dog Diseases therapy, Enteritis veterinary, Fluid Therapy veterinary, Hemostasis, Parvoviridae Infections veterinary
- Abstract
The haemostatic status of dogs with canine parvovirus (CPV) enteritis, within 24 h of admission after initial fluid administration, has been described previously, but the haemostatic status at admission and after standard fluid resuscitation, as well as after initial fluid redistribution, has not been investigated previously. The objective of this study was to characterise the haemostatic status at admission and describe the effect of crystalloid fluid resuscitation on haemostatic variables in dogs with CPV enteritis. Twenty-seven client-owned, hospitalised dogs with confirmed natural CPV infection and 15 healthy age-matched controls were included in a prospective, observational clinical study. The volume of resuscitation fluid, haematocrit (HCT), platelet count, thromboelastography (TEG) variables, antithrombin (AT) activity, fibrinogen- and C-reactive protein (CRP) concentrations were measured in all dogs at admission, after fluid resuscitation and, in 10 dogs, after receiving an additional 3 hours of maintenance-rate crystalloid fluids. For the CPV group at admission, the median TEG reaction time (R) and maximum amplitude (MA) or clot strength, as well as the median HCT, fibrinogen and CRP concentrations, were significantly increased compared to the controls. After fluid resuscitation, median R was significantly shorter, MA significantly increased and HCT and AT activity significantly decreased compared to admission values. The haemostatic variables remained unchanged after 3 h of maintenance-rate crystalloid therapy. The increased clot strength present in dogs with CPV enteritis at admission was exacerbated after fluid resuscitation and persisted for hours after large-volume crystalloid fluid administration.
- Published
- 2020
- Full Text
- View/download PDF
12. Prevalence of Salmonella in juvenile dogs affected with parvoviral enteritis.
- Author
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Botha WJ, Schoeman JP, Marks SL, Whitehead Z, and Annandale CH
- Subjects
- Aging, Animals, Case-Control Studies, Cohort Studies, Coinfection, Dog Diseases microbiology, Dogs, Enteritis complications, Feces microbiology, Longitudinal Studies, Parvoviridae Infections complications, Prevalence, Prospective Studies, Salmonella Infections, Animal complications, Dog Diseases virology, Enteritis veterinary, Parvoviridae Infections veterinary, Salmonella isolation & purification, Salmonella Infections, Animal microbiology
- Abstract
Salmonellosis is a disease of major zoonotic importance and canine parvovirus is a potentially fatal cause of canine enteritis with a world-wide distribution. Persistent isolation of Salmonella during routine environmental sampling surveys of a hospital ward, reserved for the treatment of dogs with canine parvovirus infection, prompted investigation into a possible source. We hypothesised that dogs affected by canine parvovirus would have a higher prevalence of faecal salmonellae compared to an apparently healthy cohort. Seventy-four client-owned dogs naturally infected with canine parvovirus and 42 apparently healthy client-owned dogs were included in the study. This prospective, longitudinal, observational study was conducted over an 18-month period. Fresh faecal samples were collected from dogs aged 6 weeks to 9 months diagnosed with canine parvovirus infection and admitted for treatment, and from apparently healthy dogs presented for vaccination or routine hospital procedures. Faeces were submitted for the isolation, antimicrobial susceptibility testing and serotyping of salmonellae. The prevalence of faecal Salmonella shedding was 22% and 31% for the affected and apparently healthy dogs, respectively, which was not statistically different. No significant associations between Salmonella status and possible risk factors or continuous variables such as age, body weight and duration of hospitalisation were identified. All the Salmonella isolates (n = 32) were resistant to penicillin G, lincomycin and tylosin. Salmonellae from nine different serotypes were identified. The prevalence of Salmonella shedding in both groups was higher than that commonly reported, yet similar to those in previous reports on young dogs, shelter dogs or dogs fed a raw meat diet.
- Published
- 2018
- Full Text
- View/download PDF
13. Paraquat intoxication and associated pathological findings in three dogs in South Africa.
- Author
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Williams JH, Whitehead Z, and Van Wilpe E
- Subjects
- Animals, Dog Diseases pathology, Dogs, Male, Poisoning veterinary, Dog Diseases chemically induced, Herbicides poisoning, Paraquat poisoning
- Abstract
Paraquat is a bipyridylium non-selective contact herbicide commonly used worldwide. When ingestion occurs by humans and animals either accidentally, intentionally or maliciously, paraquat selectively accumulates in the lungs resulting in the production of oxygen-free radicals, causing membrane damage and cell death. Intoxicated subjects typically show progressive and fatal pulmonary haemorrhage, collapse and oedema. In individuals surviving the acute phase, pulmonary fibrosis develops. Gastrointestinal-, renal- and central nervous system clinical signs may also occur. Owing to the lack of effective treatment and absence of an antidote, the prognosis is poor. The clinical presentation, clinicopathological findings and treatment are briefly described of three dogs from one South African household, intoxicated with paraquat. Macroscopic and microscopic lesions in one dog that was necropsied, as well as pulmonary ultrastructure are detailed and illustrated for academic reference. All dogs presented with tachypnoea and dyspnoea 2-3 days after accidental paraquat ingestion. Treatment was aimed at reducing gastrointestinal absorption, enhancing elimination by diuresis and avoiding further oxidative damage by administration of antioxidants. All dogs, however, became progressively hypoxic despite treatment and were euthanised. Paraquat toxicity should be a differential diagnosis in dogs with unexplained progressive respiratory and gastrointestinal signs and renal failure. The local veterinary profession should be aware of accidental or intentional paraquat toxicity of animals. Existing literature, variations possible in canine clinical signs, measured parameters, lesions, as well as possible treatments, promising experimental antidotes and management options are discussed.
- Published
- 2016
- Full Text
- View/download PDF
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