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The article discusses that the war in Ukraine has been fought with the conventional and economic weapon of diverse mechanisms of economic and financial coercion. The language of economic coercion and submission highlights the connection between sanctions and other forms of economic pressure that are central to the operation of the world economy, from debt conditionality to the silent compulsion of economic relations.

The article focuses on importance of socialist calculation with development and intellectual clarification of those strands of classical liberalism that would ultimately metamorphose into neoliberalism. It mentions systematic perversion of the relation between market demand and social needs and social waste in the form of ecological damage, contamination of waterways, ill health, and work injuries. It also mentions rise of economic planning with vision of civilizational development.

Friedrich Hayek repeatedly stressed the centrality of submission to his own account of spontaneous order. In what he depicted as the rationalist refusal to submit to anything beyond human comprehension, he saw a threat to the "spontaneous order" of a market society. Kyong-Min Son's criticism of my account of the neoliberal subject provides me with an opportunity to further specify my understanding of the submissive disposition of the Hayekian subject. In this brief reply, I defend the claim that Hayek saw the complexity and opacity of the market order as constraining the possibility of collective political intervention that aims to alter the outcomes of market competition. While Hayek theorized a subject who was actively invested in the competitive "game," the premise of this investment was submission to the rules of the market and acceptance of its outcomes as a form of fate. [ABSTRACT FROM AUTHOR]

Friedrich Hayek's account of "spontaneous order" has generated increasing interest in recent decades. His argument for the superiority of the market in distributing knowledge without the need for central oversight has appealed to progressive democratic theorists, who are wary of the hubris of state planning and attracted to possibilities for self-organization, and to Foucaultians, who have long counseled political theory to cut off the King's head. A spontaneous social order, organized by an invisible hand, would appear to dispense with arbitrary power and foster creativity and individual liberty. This article challenges this view by highlighting the centrality of submission to Hayek's account of spontaneous order. It shows that Hayek struggles to obscure the providentialism underpinning the account of social order he derives from Adam Ferguson and the Scottish Enlightenment. Nonetheless, his own account of spontaneous order relies on faith in the workings of the market, and submission to unintelligible market forces. [ABSTRACT FROM AUTHOR]

Objective: Generalized anxiety disorder (GAD) is a debilitating condition, characterized by negative interpretations about ambiguous situations. This study tested whether entirely internet-delivered interpretation training [cognitive bias modification (CBM)] versus control promotes positive interpretations and reduces worry and anxiety in individuals with GAD, with or without depression. Method: A two-arm (CBM; control) parallel-group randomized controlled experiment. Assessments were preintervention (T0), postintervention (T1), 1-month (T2) postintervention, and 3-month (T3) postintervention. Participants with GAD (with or without comorbid depression) were randomly allocated to either CBM (n = 115) or control (n = 115). Participants, but not researchers, were blind to allocated condition. Participants completed up to 10 online CBM or control sessions across 1 month. Interpretation bias [coprimary outcomes: scrambled sentence test (SST), recognition test (RT)], and number of negative thought intrusions during a breathing focus task were measured at T0 and T1. Self-reported levels of worry [Penn State Worry Questionnaire-trait (PSWQ trait); Penn State Worry Questionnaire-past week (PSWQ weekly)], anxiety [Generalized Anxiety Disorder scale (GAD-7)], depression [Patient Health Questionnaire (PHQ-9)], rumination [Ruminative Response Scale (RRS)], and repetitive negative thinking [RNT; Repetitive Thinking Questionnaire-trait (RTQ-trait)] were assessed at T0–T3. Results: The per-protocol analyses included N = 186 participants (CBM n = 94; control n = 92). As predicted, we found moderate-to-large training effects on the primary outcome of interpretation bias at T1. Secondary outcomes of negative thought intrusions at T1 and self-reported symptoms at T2 were all significantly lower in the CBM versus control condition. All but one effect (trait RNT) were sustained at T3. Conclusions: In this randomized controlled study, we found that fully online interpretation training ameliorated core features of GAD in individuals with or without comorbid depression up to 3 months posttraining. What is the public health significance of this article?: Generalized anxiety disorder (GAD) is a common debilitating problem with uncontrollable worry at its core. It often co-occurs with clinical depression. The tendency to draw negative conclusions from unclear/ambiguous information (interpretation bias) maintains worry, anxiety, and depression. This web-based study of people with GAD (with or without depression) used computerized practice in generating positive interpretations and compared this training to another (control) condition which did not alter interpretations. Positive interpretation training reduced worry, anxiety, and depression up to 3 months after training finished. The effects were due to changes in interpretation bias. Given the online nature of the interpretation training, this indicates for the first time that interpretation training can be effective when delivered remotely to people suffering from GAD with or without depression, opening up the possibility that this approach could be used to help people recover from anxiety and depression without attending a clinic. [ABSTRACT FROM AUTHOR]

Objective: Repetitive negative thinking (RNT; e.g., worry and rumination) is common across emotional disorders, as is the tendency to generate negative interpretations (interpretation bias). Ameliorating negative interpretations via cognitive bias modification of interpretations (CBM-I) reduces worry/rumination, and improves mood in people diagnosed with generalized anxiety disorder (GAD) or depression. We investigated whether these findings generalize to high worry or rumination populations, irrespective of diagnosis, and whether effects are increased by enhancing emotional engagement with training with active generation of positive resolutions of ambiguity and imagery. Method: Community volunteers with excessive worry and/or rumination, who were above clinical cut-off on anxiety and/or depression measures, were allocated to an active control condition (n = 54), interpretation training condition with prior activation of RNT (CBM_RNT; n = 54), or training condition augmented with positive outcome generation and imagery (CBM_ENH; n = 53). Interpretation bias, RNT, and mood were assessed before and following 10 Internet-based sessions completed within a 1-month period. RNT and mood questionnaires were also completed at 1-month follow-up. Results: After training, both forms of CBM-I (vs. control) facilitated more positive interpretations and reduced negative intrusions during a worry task. At 1-month follow-up, anxiety, depression, RNT, and worry in the past week were lower in the CBM-I than control conditions, but not rumination or trait worry. Compared with standard CBM-I, the augmented form facilitated more positive interpretations, reduced negative intrusions after training, and reduced trait rumination at 1-month follow-up, but it did not augment effects on trait worry, anxiety or depression. Conclusions: Interpretation bias maintains transdiagnostic RNT and Internet-based CBM-I can reduce longer-term RNT. What is the public health significance of this article?: Worrying about the future or mulling over negative events from the past (rumination) is common in people experiencing anxiety and depression. Importantly, these types of unhelpful repetitive negative thinking can maintain anxious and depressed mood. This study indicates that simple regular practice in making positive interpretations of emotionally ambiguous information reduces repetitive negative thinking and improves mood in people with high levels of worry or rumination. [ABSTRACT FROM AUTHOR]

Objective: Repetitive negative thinking (RNT) for example, worry in generalized anxiety disorder (GAD) and rumination in depression, is often targeted during psychological treatments. To test the hypothesis that negative interpretation bias contributes to worry and rumination, we assessed the effects of inducing more positive interpretations in reducing RNT. Method: Volunteers diagnosed with GAD (66) or depression (65) were randomly allocated to one of two versions of cognitive bias modification for interpretation (CBM-I), either with or without RNT priming prior to training, or a control condition, each involving 10 Internet-delivered sessions. Outcome measures of interpretation bias, a behavioral RNT task and self-reported worry, rumination, anxiety and depression were obtained at baseline, after home-based training and at 1-month follow-up (self-report questionnaires only). Results: CBM-I training, across diagnostic groups, promoted a more positive interpretation bias and led to reductions in worry, rumination, and depressive symptoms, which were maintained at follow-up. Anxiety symptoms were reduced only in the GAD group at follow-up. There were no differences between CBM-I versions; brief priming of RNT did not influence CBM-I effectiveness. Level of interpretation bias post training partially mediated the effects of CBM-I on follow-up questionnaire scores. Conclusions: In contrast to some recent failures to demonstrate improvements following Internet-delivered CBM, we found that selfreported RNT and negative mood were reduced by CBM-I. This is consistent with a causal role for negative interpretation bias in both worry and rumination, suggesting a useful role for CBM-I within treatments for anxiety and depression. [ABSTRACT FROM AUTHOR]

The article looks on Giorgio Agamben's use of the self in his book "Homo Sacer: Sovereign Power and Bare Life." According to the author, Agamben's non-identitarian form of singularity is constitutive of the coming form-of-life. In his account of singularity, Agamben claim that all social classes has been dissolved by the society of spectacle.

The fungal pathogen Cryptococcus neoformans is a leading cause of meningoencephalitis in the immunocompromised. As current antifungal treatments are toxic to the host, costly, limited in their efficacy, and associated with drug resistance, there is an urgent need to identify vulnerabilities in fungal physiology to accelerate antifungal discovery efforts. Rational drug design was pioneered in de novo purine biosynthesis as the end products of the pathway, ATP and GTP, are essential for replication, transcription, and energy metabolism, and the same rationale applies when considering the pathway as an antifungal target. Here, we describe the identification and characterization of C. neoformans 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/5'-inosine monophosphate cyclohydrolase (ATIC), a bifunctional enzyme that catalyzes the final two enzymatic steps in the formation of the first purine base inosine monophosphate. We demonstrate that mutants lacking the ATIC-encoding ADE16 gene are adenine and histidine auxotrophs that are unable to establish an infection in a murine model of virulence. In addition, our assays employing recombinantly expressed and purified C. neoformans ATIC enzyme revealed Km values for its substrates AICAR and 5-formyl-AICAR are 8-fold and 20-fold higher, respectively, than in the human ortholog. Subsequently, we performed crystallographic studies that enabled the determination of the first fungal ATIC protein structure, revealing a key serine-to-tyrosine substitution in the active site, which has the potential to assist the design of fungus-specific inhibitors. Overall, our results validate ATIC as a promising antifungal drug target. [ABSTRACT FROM AUTHOR]

Ankylosing spondylitis (AS) is an inflammatory disease leading to spine ankylosis; however, the mechanisms behind new bone formation are still not fully understood. Single Nucleotide Polymorphisms (SNPs) in PTGER4, encoding for the receptor EP4 of prostaglandin E2 (PGE2), are associated with AS. Since the PGE2-EP4 axis participates in inflammation and bone metabolism, this work aims at investigating the influence of the prostaglandin-E2 axis on radiographic progression in AS. In 185 AS (97 progressors), baseline serum PGE2 predicted progression, and PTGER4 SNP rs6896969 was more frequent in progressors. Increased EP4/PTGER4 expression was observed in AS circulating immune cells, synovial tissue, and bone marrow. CD14highEP4 + cells frequency correlated with disease activity, and when monocytes were cocultured with mesenchymal stem cells, the PGE2/EP4 axis induced bone formation. In conclusion, the Prostaglandin E2 axis is involved in bone remodelling and may contribute to the radiographic progression in AS due to genetic and environmental upregulation. • PGE2 serum level predicts radiographic progression in Ankylosing Spondylitis. • EP4 is upregulated in AS by genetic and environmental factors. • PGE2/EP4 axis is upregulated in AS in synovial tissue, bone marrow and peripheral blood. • EP4+ circulating monocytes are increased in AS and correlated with disease activity and smoking. • PGE2/EP4 axis modulated monocyte-induced bone formation in MSCs. [ABSTRACT FROM AUTHOR]

The article discusses the highlights of the symposium "Form-of-Life: Giorgio Agamben, Ontology and Politics." The symposium celebrated the tenth anniversary of the Englisg language translation of Giorgio Agamben's book "Homo Sacer: Sovereign Power and Bare Life." Ewa Plonowska Ziarek discussed possibility and praxis in Agamben's work. Justin Clemens discussed Agamben's work on melancholia and fetishism.