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3. BMI1 nuclear location is critical for RAD51-dependent response to replication stress and drives chemoresistance in breast cancer stem cells

Author

Azzoni, Violette, Wicinski, Julien, Macario, Manon, Castagné, Martin, Finetti, Pascal, Ambrosova, Katerina, Rouault, Célia D., Sergé, Arnaud, Farina, Anne, Agavnian, Emilie, Coslet, Sergiu, Josselin, Emmanuelle, Guille, Arnaud, Adelaide, José, Zacharioudakis, Emmanouil, Castellano, Rémy, Bertucci, Francois, Birnbaum, Daniel, Rodriguez, Raphael, Charafe-Jauffret, Emmanuelle, and Ginestier, Christophe

Published
2022
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4. Supplementary Table 2 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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5. Supplementary Table 3 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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6. Supporting Information from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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7. Supplementary Figure 7 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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8. Supplementary Figure 1 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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9. Supplementary Figure 5 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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10. Supplementary Figure 3 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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11. Supplementary Figure 6 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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12. Supplementary Figure Legend from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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13. Supplementary Figure 2 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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14. Supplementary Table 1 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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15. Supplementary Figure 8 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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16. Supplementary Figure 4 from The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Author

Salvador, Marion A., primary, Wicinski, Julien, primary, Cabaud, Olivier, primary, Toiron, Yves, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Lelièvre, Hélène, primary, Kraus-Berthier, Laurence, primary, Depil, Stéphane, primary, Bertucci, François, primary, Collette, Yves, primary, Birnbaum, Daniel, primary, Charafe-Jauffret, Emmanuelle, primary, and Ginestier, Christophe, primary

Published
2023
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17. Supplementary Table 5 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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18. Supplementary Table 3 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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19. Supplementary Table 4 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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20. Supplementary Table 7 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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21. Supplementary Methods from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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22. Supplementary Table 6 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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23. Supplementary Figures 1 - 14 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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24. Supplementary Figure Legends from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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25. Supplementary Figures 6-10 from Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Iovino, Flora, primary, Wicinski, Julien, primary, Cervera, Nathalie, primary, Finetti, Pascal, primary, Hur, Min-Hee, primary, Diebel, Mark E., primary, Monville, Florence, primary, Dutcher, Julie, primary, Brown, Marty, primary, Viens, Patrice, primary, Xerri, Luc, primary, Bertucci, François, primary, Stassi, Giorgio, primary, Dontu, Gabriela, primary, Birnbaum, Daniel, primary, and Wicha, Max S., primary

Published
2023
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26. Supplementary Figures 1-5 from Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Iovino, Flora, primary, Wicinski, Julien, primary, Cervera, Nathalie, primary, Finetti, Pascal, primary, Hur, Min-Hee, primary, Diebel, Mark E., primary, Monville, Florence, primary, Dutcher, Julie, primary, Brown, Marty, primary, Viens, Patrice, primary, Xerri, Luc, primary, Bertucci, François, primary, Stassi, Giorgio, primary, Dontu, Gabriela, primary, Birnbaum, Daniel, primary, and Wicha, Max S., primary

Published
2023
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27. Supplementary Figure Legends 1-10 from Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Iovino, Flora, primary, Wicinski, Julien, primary, Cervera, Nathalie, primary, Finetti, Pascal, primary, Hur, Min-Hee, primary, Diebel, Mark E., primary, Monville, Florence, primary, Dutcher, Julie, primary, Brown, Marty, primary, Viens, Patrice, primary, Xerri, Luc, primary, Bertucci, François, primary, Stassi, Giorgio, primary, Dontu, Gabriela, primary, Birnbaum, Daniel, primary, and Wicha, Max S., primary

Published
2023
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28. Data from Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Iovino, Flora, primary, Wicinski, Julien, primary, Cervera, Nathalie, primary, Finetti, Pascal, primary, Hur, Min-Hee, primary, Diebel, Mark E., primary, Monville, Florence, primary, Dutcher, Julie, primary, Brown, Marty, primary, Viens, Patrice, primary, Xerri, Luc, primary, Bertucci, François, primary, Stassi, Giorgio, primary, Dontu, Gabriela, primary, Birnbaum, Daniel, primary, and Wicha, Max S., primary

Published
2023
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29. Supplementary Table 2 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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30. Supplementary Table 1 from Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Iovino, Flora, primary, Wicinski, Julien, primary, Cervera, Nathalie, primary, Finetti, Pascal, primary, Hur, Min-Hee, primary, Diebel, Mark E., primary, Monville, Florence, primary, Dutcher, Julie, primary, Brown, Marty, primary, Viens, Patrice, primary, Xerri, Luc, primary, Bertucci, François, primary, Stassi, Giorgio, primary, Dontu, Gabriela, primary, Birnbaum, Daniel, primary, and Wicha, Max S., primary

Published
2023
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31. Supplementary Table 3 from Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Iovino, Flora, primary, Wicinski, Julien, primary, Cervera, Nathalie, primary, Finetti, Pascal, primary, Hur, Min-Hee, primary, Diebel, Mark E., primary, Monville, Florence, primary, Dutcher, Julie, primary, Brown, Marty, primary, Viens, Patrice, primary, Xerri, Luc, primary, Bertucci, François, primary, Stassi, Giorgio, primary, Dontu, Gabriela, primary, Birnbaum, Daniel, primary, and Wicha, Max S., primary

Published
2023
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32. Supplementary Table 1 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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33. Data from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Bertucci, François, primary, Cabaud, Olivier, primary, Wicinski, Julien, primary, Finetti, Pascal, primary, Josselin, Emmanuelle, primary, Adelaide, José, primary, Nguyen, Tien-Tuan, primary, Monville, Florence, primary, Jacquemier, Jocelyne, primary, Thomassin-Piana, Jeanne, primary, Pinna, Guillaume, primary, Jalaguier, Aurélie, primary, Lambaudie, Eric, primary, Houvenaeghel, Gilles, primary, Xerri, Luc, primary, Harel-Bellan, Annick, primary, Chaffanet, Max, primary, Viens, Patrice, primary, and Birnbaum, Daniel, primary

Published
2023
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34. Supplementary Table 2 from Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Author

Charafe-Jauffret, Emmanuelle, primary, Ginestier, Christophe, primary, Iovino, Flora, primary, Wicinski, Julien, primary, Cervera, Nathalie, primary, Finetti, Pascal, primary, Hur, Min-Hee, primary, Diebel, Mark E., primary, Monville, Florence, primary, Dutcher, Julie, primary, Brown, Marty, primary, Viens, Patrice, primary, Xerri, Luc, primary, Bertucci, François, primary, Stassi, Giorgio, primary, Dontu, Gabriela, primary, Birnbaum, Daniel, primary, and Wicha, Max S., primary

Published
2023
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36. Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Author

Mai, Trang Thi, Hamaï, Ahmed, Hienzsch, Antje, Cañeque, Tatiana, Müller, Sebastian, Wicinski, Julien, Cabaud, Olivier, Leroy, Christine, David, Amandine, Acevedo, Verónica, Ryo, Akihide, Ginestier, Christophe, Birnbaum, Daniel, Charafe-Jauffret, Emmanuelle, Codogno, Patrice, Mehrpour, Maryam, and Rodriguez, Raphaël

Published
2017
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37. XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

Author

Richart, Laia, primary, Picod-Chedotel, Mary-Loup, additional, Wassef, Michel, additional, Macario, Manon, additional, Aflaki, Setareh, additional, Salvador, Marion A., additional, Héry, Tiphaine, additional, Dauphin, Aurélien, additional, Wicinski, Julien, additional, Chevrier, Véronique, additional, Pastor, Sonia, additional, Guittard, Geoffrey, additional, Le Cam, Samuel, additional, Kamhawi, Hanya, additional, Castellano, Rémy, additional, Guasch, Géraldine, additional, Charafe-Jauffret, Emmanuelle, additional, Heard, Edith, additional, Margueron, Raphaël, additional, and Ginestier, Christophe, additional

Published
2022
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38. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

Author

Ginestier, Christophe, Liu, Suling, Diebel, Mark E., Korkaya, Hasan, Luo, Ming, Brown, Marty, Wicinski, Julien, Cabaud, Olivier, Charafe-Jauffret, Emmanuelle, Birnbaum, Daniel, Guan, Jun-Lin, Dontu, Gabriela, and Wicha, Max S.

Subjects
Metastasis -- Development and progression -- Physiological aspects -- Care and treatment, Stem cells -- Properties -- Physiological aspects, Cancer -- Care and treatment, Breast cancer -- Development and progression -- Physiological aspects -- Care and treatment, Health care industry
Abstract

Recent evidence suggests that breast cancer and other solid tumors possess a rare population of cells capable of extensive self-renewal that contribute to metastasis and treatment resistance. We report here the development of a strategy to target these breast cancer stem cells (CSCs) through blockade of the IL-8 receptor CXCR1. CXCR1 blockade using either a CXCR1-specific blocking antibody or repertaxin, a small-molecule CXCR1 inhibitor, selectively depleted the CSC population in 2 human breast cancer cell lines in vitro. Furthermore, this was followed by the induction of massive apoptosis in the bulk tumor population via FASL/FAS signaling. The effects of CXCR1 blockade on CSC viability and on FASL production were mediated by the FAK/AKT/ FOXO3A pathway. In addition, repertaxin was able to specifically target the CSC population in human breast cancer xenografts, retarding tumor growth and reducing metastasis. Our data therefore suggest that CXCR1 blockade may provide a novel means of targeting and eliminating breast CSCs., Introduction The cancer stem cell (CSC) concept has important implications for understanding carcinogenesis as well as for the development of cancer therapeutics. According to this concept, tumors are initiated and [...]

Published
2010
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39. Loss of XIST Impairs Human Mammary Stem Cell Differentiation and Increases Tumorigenicity Through Enhancer and Mediator Complex Hyperactivation

Author

Richart, Laia, primary, Picod, Mary-Loup, additional, Wassef, Michel, additional, Macario, Manon, additional, Aflaki, Setareh, additional, Salvador, Marion A., additional, Wicinski, Julien, additional, Chevrier, Véronique, additional, Le Cam, Samuel, additional, Kamhawi, Hanya A., additional, Castellano, Rémy, additional, Guasch, Géraldine, additional, Charafe-Jauffret, Emmanuelle, additional, Heard, Edith, additional, Margueron, Raphaël, additional, and Ginestier, Christophe, additional

Published
2021
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40. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer

Author

Sircoulomb, Fabrice, Nicolas, Nathalie, Ferrari, Anthony, Finetti, Pascal, Bekhouche, Ismahane, Rousselet, Estelle, Lonigro, Aurélie, Adélaïde, José, Baudelet, Emilie, Esteyriès, Séverine, Wicinski, Julien, Audebert, Stéphane, Charafe-Jauffret, Emmanuelle, Jacquemier, Jocelyne, Lopez, Marc, Borg, Jean-Paul, Sotiriou, Christos, Popovici, Cornel, Bertucci, François, Birnbaum, Daniel, Chaffanet, Max, and Ginestier, Christophe

Published
2011
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41. A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells

Author

Arfaoui, Abir, Rioualen, Claire, Azzoni, Violette, Pinna, Guillaume, Finetti, Pascal, Wicinski, Julien, Josselin, Emmanuelle, Macario, Manon, Castellano, Rémy, Léonard-Stumpf, Candi, Bal, Anthony, Gros, Abigaelle, Lossy, Sylvain, Kharrat, Maher, Collette, Yves, Bertucci, Francois, Birnbaum, Daniel, Douik, Hayet, Bidaut, Ghislain, Charafe-Jauffret, Emmanuelle, Ginestier, Christophe, Léonard‐Stumpf, Candi, Charafe‐Jauffret, Emmanuelle, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Tunis El Manar (UTM), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), PARi (PARI), Département Plateforme (PF I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Service de Biologie Intégrative et Génétique Moléculaire (SBIGeM), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut Salah Azaiz, Theories and Approaches of Genomic Complexity (TAGC), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Cancérologie, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), and Bidaut, Ghislain

Subjects
cancer stem cells, Medicine (General), [SDV]Life Sciences [q-bio], JQ1, PARI, Antineoplastic Agents, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, QH426-470, Regenerative Medicine, Article, R5-920, breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Drug Discovery, Chemical Biology, Tumor Cells, Cultured, Genetics, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Gene Regulatory Networks, Genetic Testing, Protein Interaction Maps, Cancer, RNAi screen, Articles, Neoplastic Stem Cells, salinomycin, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Female, RNA Interference, PF, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Genome-Wide Association Study
Abstract

International audience; Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic target to improve cancer treatment. Here, we carried out a genome-wide RNA interference screen to identify genes that regulate breast CSCs-fate (bCSC). Using an interactome/regulome analysis, we integrated screen results in a functional mapping of the CSC-related processes. This network analysis uncovered potential therapeutic targets controlling bCSC-fate. We tested a panel of 15 compounds targeting these regulators. We showed that mifepristone, salinomycin, and JQ1 represent the best anti-bCSC activity. A combination assay revealed a synergistic interaction of salinomycin/JQ1 association to deplete the bCSC population. Treatment of primary breast cancer xenografts with this combination reduced the tumor-initiating cell population and limited metastatic development. The clinical relevance of our findings was reinforced by an association between the expression of the bCSC-related networks and patient prognosis. Targeting bCSCs with salinomycin/JQ1 combination provides the basis for a new therapeutic approach in the treatment of breast cancer.

Published
2019

42. Ex vivo CSC assays for personalized testing of drug susceptibility in advanced breast cancer

Author

Charafe-Jauffret, Emmanuelle, Wicinski, Julien, Cabaud, Olivier, Lopez, Marc, Audebert, Stephane, Adelaide, Jose, Chaffanet, Max, Guille, Arnaud, Goncalves, Anthony, Bertucci, Francois, Birnbaum, Daniel, Ginestier, Christophe, Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

San Antonio Breast Cancer Symposium, San Antonio, TX, DEC 05-09, 2017

Published
2018

43. A genome‐wide RNA i screen reveals essential therapeutic targets of breast cancer stem cells

Author

Arfaoui, Abir, primary, Rioualen, Claire, additional, Azzoni, Violette, additional, Pinna, Guillaume, additional, Finetti, Pascal, additional, Wicinski, Julien, additional, Josselin, Emmanuelle, additional, Macario, Manon, additional, Castellano, Rémy, additional, Léonard‐Stumpf, Candi, additional, Bal, Anthony, additional, Gros, Abigaelle, additional, Lossy, Sylvain, additional, Kharrat, Maher, additional, Collette, Yves, additional, Bertucci, Francois, additional, Birnbaum, Daniel, additional, Douik, Hayet, additional, Bidaut, Ghislain, additional, Charafe‐Jauffret, Emmanuelle, additional, and Ginestier, Christophe, additional

Published
2019
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44. The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling

Author

Lopez Almeida, Leonor, primary, Sebbagh, Michael, additional, Bertucci, François, additional, Finetti, Pascal, additional, Wicinski, Julien, additional, Marchetto, Sylvie, additional, Castellano, Rémy, additional, Josselin, Emmanuelle, additional, Charafe-Jauffret, Emmanuelle, additional, Ginestier, Christophe, additional, Borg, Jean-Paul, additional, and Santoni, Marie-Josée, additional

Published
2018
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45. A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability

Author

Morel, Anne-Pierre, primary, Ginestier, Christophe, additional, Pommier, Roxane M, additional, Cabaud, Olivier, additional, Ruiz, Emmanuelle, additional, Wicinski, Julien, additional, Devouassoux-Shisheboran, Mojgan, additional, Combaret, Valérie, additional, Finetti, Pascal, additional, Chassot, Christelle, additional, Pinatel, Christiane, additional, Fauvet, Frédérique, additional, Saintigny, Pierre, additional, Thomas, Emilie, additional, Moyret-Lalle, Caroline, additional, Lachuer, Joël, additional, Despras, Emmanuelle, additional, Jauffret, Jean-Luc, additional, Bertucci, François, additional, Guitton, Jérôme, additional, Wierinckx, Anne, additional, Wang, Qing, additional, Radosevic-Robin, Nina, additional, Penault-Llorca, Frédérique, additional, Cox, David G, additional, Hollande, Frédéric, additional, Ansieau, Stéphane, additional, Caramel, Julie, additional, Birnbaum, Daniel, additional, Vigneron, Arnaud M, additional, Tissier, Agnès, additional, Charafe-Jauffret, Emmanuelle, additional, and Puisieux, Alain, additional

Published
2017
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46. miR-600 Acts as a Bimodal Switch that Regulates Breast Cancer Stem Cell Fate through WNT Signaling

Author

El Helou, Rita, primary, Pinna, Guillaume, additional, Cabaud, Olivier, additional, Wicinski, Julien, additional, Bhajun, Ricky, additional, Guyon, Laurent, additional, Rioualen, Claire, additional, Finetti, Pascal, additional, Gros, Abigaelle, additional, Mari, Bernard, additional, Barbry, Pascal, additional, Bertucci, Francois, additional, Bidaut, Ghislain, additional, Harel-Bellan, Annick, additional, Birnbaum, Daniel, additional, Charafe-Jauffret, Emmanuelle, additional, and Ginestier, Christophe, additional

Published
2017
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50. Abstract 3020: Patient-derived xenograft (PDX) models to study the role of breast cancer stem cells in metastasis formation

Author

Ginestier, Christophe, primary, Lartigue, Danae, additional, Cabaud, Olivier, additional, Malzac, Aurelie, additional, Wicinski, Julien, additional, Josselin, Emmanuelle, additional, Finetti, Pascal, additional, Adelaide, Jose, additional, Bertucci, Francois, additional, Chaffanet, Max, additional, Birnbaum, Daniel, additional, and Charafe-Jauffret, Emmanuelle, additional

Published
2014
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