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311 results on '"Wiegandt H"'

10. Oligosaccharide der Frauenmilch

Author

Wiegandt, H., Egge, H., Bromer, W., Egge, H., Eiter, K., Eyjólfsson, R., Gross, D., Hikino, H., Hikino, Y., Jackson, B. G., Morin, R. B., Pike, J. E., Warnhoff, E. W., Wiegandt, H., Wong, E., Herz, W., editor, Grisebach, H., editor, and Scott, A. I., editor

Published
1970
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11. Spezielle blutchemische Untersuchungsmethoden

Author

Betzing, H., Blankenhorn, D. H., Böhle, E., Böhm, P., Braunsteiner, H., Eberhagen, Dietrich, Eggstein, M., Frosch, B., Kirsch, Katharina, Kremer, G., Richarz, G., Sailer, S., Sandhofer, F., Tiews, J., Wagener, H., Wiegandt, H., Wolfram, G., Zöllner, Nepomuk, Betzing, H., editor, Blankenhorn, D. H., editor, Böhle, E., editor, Böhm, P., editor, Braunsteiner, H., editor, Eberhagen, Dietrich, editor, Eggstein, M., editor, Frosch, B., editor, Kirsch, Katharina, editor, Kremer, G., editor, Richarz, G., editor, Sailer, S., editor, Sandhofer, F., editor, Tiews, J., editor, Wagener, H., editor, Wiegandt, H., editor, Wolfram, G., editor, and Zöllner, Nepomuk, editor

Published
1965
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12. Allgemeine Untersuchungsmethoden

Author

Betzing, H., Blankenhorn, D. H., Böhle, E., Böhm, P., Braunsteiner, H., Eberhagen, Dietrich, Eggstein, M., Frosch, B., Kirsch, Katharina, Kremer, G., Richarz, G., Sailer, S., Sandhofer, F., Tiews, J., Wagener, H., Wiegandt, H., Wolfram, G., Zöllner, Nepomuk, Betzing, H., editor, Blankenhorn, D. H., editor, Böhle, E., editor, Böhm, P., editor, Braunsteiner, H., editor, Eberhagen, Dietrich, editor, Eggstein, M., editor, Frosch, B., editor, Kirsch, Katharina, editor, Kremer, G., editor, Richarz, G., editor, Sailer, S., editor, Sandhofer, F., editor, Tiews, J., editor, Wagener, H., editor, Wiegandt, H., editor, Wolfram, G., editor, and Zöllner, Nepomuk, editor

Published
1965
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13. Anhang

Author

Betzing, H., Blankenhorn, D. H., Böhle, E., Böhm, P., Braunsteiner, H., Eberhagen, Dietrich, Eggstein, M., Frosch, B., Kirsch, Katharina, Kremer, G., Richarz, G., Sailer, S., Sandhofer, F., Tiews, J., Wagener, H., Wiegandt, H., Wolfram, G., Zöllner, Nepomuk, Betzing, H., editor, Blankenhorn, D. H., editor, Böhle, E., editor, Böhm, P., editor, Braunsteiner, H., editor, Eberhagen, Dietrich, editor, Eggstein, M., editor, Frosch, B., editor, Kirsch, Katharina, editor, Kremer, G., editor, Richarz, G., editor, Sailer, S., editor, Sandhofer, F., editor, Tiews, J., editor, Wagener, H., editor, Wiegandt, H., editor, Wolfram, G., editor, and Zöllner, Nepomuk, editor

Published
1965
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14. Chemische Einführung

Author

Betzing, H., Blankenhorn, D. H., Böhle, E., Böhm, P., Braunsteiner, H., Eberhagen, Dietrich, Eggstein, M., Frosch, B., Kirsch, Katharina, Kremer, G., Richarz, G., Sailer, S., Sandhofer, F., Tiews, J., Wagener, H., Wiegandt, H., Wolfram, G., Zöllner, Nepomuk, Betzing, H., editor, Blankenhorn, D. H., editor, Böhle, E., editor, Böhm, P., editor, Braunsteiner, H., editor, Eberhagen, Dietrich, editor, Eggstein, M., editor, Frosch, B., editor, Kirsch, Katharina, editor, Kremer, G., editor, Richarz, G., editor, Sailer, S., editor, Sandhofer, F., editor, Tiews, J., editor, Wagener, H., editor, Wiegandt, H., editor, Wolfram, G., editor, and Zöllner, Nepomuk, editor

Published
1965
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22. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3

Author

Rabionet, M, van der Spoel, AC, Chuang, CC, von Tümpling-Radosta, B, Litjens, M, Bouwmeester, D, Hellbusch, CC, Körner, C, Wiegandt, H, Gorgas, K, Platt, FM, Gröne, HJ, and Sandhoff, R

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Previously, it was found that a novel class of neutral fucosylated glycosphingolipids (GSLs) is required for male fertility. These lipids contain very long-chain (C26-C32) polyunsaturated (4-6 double bonds) fatty acid residues (VLC-PUFAs). To assess the role of these complex GSLs in spermatogenesis, we have now investigated with which of the testicular cell types these lipids are associated. During postnatal development, complex glycosylated and simple VLC-PUFA sphingolipids were first detectable at day 15, when the most advanced germ cells are pachytene spermatocytes. Their synthesis is most likely driven by ceramide synthase-3. This enzyme is encoded by the Cers3/Lass3 gene (longevity assurance genes), and out of six members of this gene family, only Cers3 mRNA expression was limited to germ cells, where it was up-regulated more than 700-fold during postnatal testicular maturation. Increasing levels of neutral complex VLC-PUFA GSLs also correlated with the progression of spermatogenesis in a series of male sterile mutants with arrests at different stages of spermatogenesis. Remarkably, fucosylation of the complex VLC-PUFA GSLs was not essential for spermatogenesis, as fucosylation-deficient mice produced nonfucosylated versions of the complex testicular VLC-PUFA GSLs, had complete spermatogenesis, and were fertile. Nevertheless, sterile Galgt1(-/-) mice, with a defective meiotic cytokinesis and a subsequent block in spermiogenesis, lacked complex but contained simple VLC-PUFA GSLs, as well as VLC-PUFA ceramides and sphingomyelins, indicating that the latter lipids are not sufficient for completion of spermatogenesis. Thus, our data imply that both glycans and the particular acyl chains of germinal sphingolipids are relevant for proper completion of meiosis.

Published
2016

35. Mouse Models with Gene Deletions of Enzymes and Cofactors Involved in Sphingolipid Synthesis and Degradation.

Author

Jennemann, R., Gröne, H. -J., Wiegandt, H., and Sandhoff, R.

Abstract

Sphingolipids are constituents of the cell membrane. They are believed to play critical roles in many cellular events such as signaling, in modulation of cell adhesion, and as receptor molecules in cell recognition. They may also be involved in cell differentiation, cancer development, and intracellular transport. The core constituent of sphingolipids is a sphingosine base. Acylation of the aminogroup leads to ceramide. Furthermore, carbohydrates, a phosphate, or phosphorylcholine may be linked to ceramide resulting into glycosphingolipids, ceramide-1-phosphate, and sphingomyelin. Linkage of a phosphate group to sphingosine leads to sphingosine-1-phosphate. Mouse models with gene deletions of enzymes necessary for sphingolipid synthesis and degradation have been generated. These models provide insights into the cellular functions of sphingolipids. [ABSTRACT FROM AUTHOR]

Published
2010
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46. Immunological recognition of larval Taenia crassiceps glycolipids by sera from parasite-infected mice.

Author

Kunz, J., Baumeister, S., Dennis, R., Küytz, Barbara, Wiegandt, H., and Geyer, E.

Abstract

The isolation and purification of a neutral glycolipid fraction from Taenia crassiceps metacestodes (KBS strain), harvested from both male and female NMRI mice at 70-80 days following intraperitoneal infection, revealed 24 thin-layer chromatography-designated glycolipid bands. The glycolipids were defined as ceramide mono-( n=3), di-( n=3), tri-( n=4), tetra-( n=5), and >tetrasaccharides ( n=9) according to their running properties as defined by thin-layer chromatography against standards of known structure. The defined glycolipids were tested for immunoreactivity with sera from noninfected and T. crassiceps-infected NMRI mice (intraperitoneal injection or implantation of 15 larvae/animal) using the enzyme-linked immunosorbent assay (ELISA) until day 33 p.i. (IgM and IgG reaction) and high-performance thin-layer chromatography (HPTLC) combined with immunostaining (IgG reaction) until day 7 p.i. ELISA-determined IgM and IgG titres were significantly elevated from day 5 p.i. Immunostaining revealed early reactivity for certain ceramide tetra- and >tetrasaccharides ( n=6) on day 3 p.i. From day 5 p.i. onwards, nearly all glycolipids, including ceramide mono-and disaccharides, were recognized by the sera from metacestode-challenged mice. On day 7 p.i., a total of 22 bands were serologically active; of these, a considerable number ( n=10) showed increased staining intensity. Remarkably, in many cases (10 of 20), 3 glycolipids (tetra-and >tetrasaccharides) were weakly recognized by mouse sera taken before infection. [ABSTRACT FROM AUTHOR]

Published
1991
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