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22. Ritanserin In Relapse Prevention In Abstinent Alcoholics: Results From a Placebo-Controlled Double-Blind International Multicenter Trial.

Author

Wiesbeck, G.A., Weijers, H.-G., Chick, J., Naranjo, C.A., and Boening, J.

Abstract

Ritanserin, a long-acting specific 5-HT2 receptor antagonist, revealed promising effects on alcohol intake behavior in both animal and preliminary human studies. To test its effectiveness in alcohol dependence this phase III clinical trial was initiated. In a placebo-controlled, randomized, double-blind international multicenter study 493 patients with moderate or severe alcohol dependence (DSM-III-R) were treated with three doses of ritanserin 2.5 mg/day ( n= 122), 5 mg/day ( n= 123), 10 mg/day ( n= 126), or placebo ( n= 122) over a period of 6 months. Ritanserin was well tolerated. The most frequent adverse experiences were headache and insomnia. A small increase in weight in the ritanserin-treated patients was observed. There were no significant differences between any dose of ritanserin and placebo in the relapse-rate, the time to relapse, craving for alcohol, or quantity and frequency of drinking after relapse. So far, neither ritanserin nor any other serotonergic medication has shown its specific effectiveness in relapse prevention in alcohol dependence. [ABSTRACT FROM AUTHOR]

Published
1999
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23. A Three-Axes Approach of Subtyping the Alcohol Dependence Syndrome

Author

Wiesbeck, G.A., Dürsteler-MacFarland, K.M., Walter, M., Weijers, H.-G., and Boening, J.

Abstract

AbstractSubtyping of alcoholics according to specific characteristics has a long tradition in alcoholism research with a number of different typologies that emerged in the literature. The goal of the present study was to test a multidimensional approach of subtyping with characteristics from different axes. Therefore, male inpatients meeting ICD-10 criteria for alcohol dependence were rated on three axes by assessing their degree of sensation seeking (personality axis), age of alcoholism onset (clinical axis) and level of dopamine activity (neurobiological axis). By using a configuration frequency analysis, we identified a subtype that was characterized by high sensation seeking early age of alcoholism onset and high dopamine activity. This subtype, which is in accordance with clinical experience and cannot be explained by antisocial personality disorder, embodied a significantly greater proportion of alcoholics than expected. The result emphasizes the usefulness of multidimensional approaches integrating personality, clinical and neurobiological characteristics.Copyright © 2005 S. Karger AG, Basel

Published
2005

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