110 results on '"Wigley, W Christian"'
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2. Dynamic Association of Proteasomal Machinery with the Centrosome
3. A Screen to Identify Cellular Modulators of Soluble Levels of an Amyotrophic Lateral Sclerosis (ALS)–Causing Mutant SOD1
4. Hsp90 Inhibition: A Promising Therapeutic Approach for ARSACS
5. Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD.
6. A novel series of cysteine-dependent, allosteric inverse agonists of the nuclear receptor RORγt
7. Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD.
8. Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD
9. Transmembrane domain of cystic fibrosis transmembrane conductance regulator: design, characterization, and secondary structure of synthetic peptides m1-m6
10. Restriction fragment length polymorphism (RFLP) analysis provides evidence for a high degree of homology of mitochondrial DNAs from rat hepatomasVersus normal rat livers
11. Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme
12. LIST OF CONTRIBUTORS
13. The Molecular Genetics of Steroid 5α-Reductases
14. Bardoxolone methyl analog attenuates proteinuria‐induced tubular damage by modulating mitochondrial function
15. Hook2 contributes to aggresome formation
16. Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD.
17. Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function.
18. NRF2 as an Emerging Therapeutic Target
19. Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding
20. Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405
21. RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity
22. Assessment of Protein Folding/Solubility in Live Cells
23. Aggresome Formation
24. CFTR Degradation and Aggregation
25. In Vitro CFTR Folding Assays
26. Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity
27. The synthetic triterpenoid, RTA 405, increases the glomerular filtration rate and reduces angiotensin II–induced contraction of glomerular mesangial cells
28. Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents
29. ChemInform Abstract: Synthesis and Biological Evaluation of 1‐[2‐Cyano‐3,12‐dioxooleana‐1,9(11)‐dien‐28‐oyl]‐4‐ethynylimidazole. A Novel and Highly Potent Antiinflammatory and Cytoprotective Agent.
30. Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1
31. 319: Bardoxolone Methyl (BARD) Inhibits Inflammatory Signaling in Cultured Mesangial Cells
32. Hook2 contributes to aggresome formation
33. A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex
34. A protein sequence that can encode native structure by disfavoring alternate conformations
35. Aggresome Formation.
36. Protein solubility and folding monitored in vivo by structural complementation of a genetic marker protein
37. In Vitro CFTR Folding Assays.
38. CFTR Degradation and Aggregation.
39. Activity and Regulation of the Centrosome-associated Proteasome
40. Regulation of Cl−/ HCO3−Exchange by Cystic Fibrosis Transmembrane Conductance Regulator Expressed in NIH 3T3 and HEK 293 Cells
41. Natural Mutagenesis Study of the Human Steroid 5.alpha.-Reductase 2 Isoenzyme
42. Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.
43. Detection of a progression‐linked DNA restriction fragment in rat hepatoma cells probed with a hexokinase CDNA
44. Synthesis, Chemical Reactivityas Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones,Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents(1).
45. Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.
46. Interferon γ regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies
47. A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex.
48. Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD.
49. Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.
50. Aggresome formation.
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