Search

Background: We report on our experience of the surgical management and outcomes of 11 patients with solid pseudopapillary tumour of the pancreas (SPT). We sought to correlate the immunohistochemical staining of these tumours with that previously reported in the literature. Methods: A retrospective analysis of the clinical presentation, radiological findings, surgical treatment, histopathological characteristics and outcomes for patients surgically managed with SPT at The Royal London Hospital. A literature search was performed to analyse the immunohistochemical stains commonly used to diagnose SPT. Results: Between August 2006 and April 2016, 10 females and one male patient underwent surgery for SPT. The localization of the tumour was in the pancreatic head in two patients, one in the neck, three in the body and five in the tail. All 11 patients had localised disease. Six patients suffered post‐surgical complications. Histopathology shows immunoreactivity for: β‐catenin, vimentin, CD‐10, CD‐56, α1‐antitrypsin and negative staining for synaptophysin and chromogranin. At a median of 24 months of follow‐up, the disease‐free survival rate was 100% and no recurrence was noted. A literature review generated 38 suitable articles with 116 individual cases of SPT, with high expression of vimentin and neuron specific enolase throughout, and low rates of chromogranin and synatophysin positivity. Conclusion: SPT is rare and affects mostly young women. An accurate diagnosis is important as the relative indolent behaviour can be managed with surgical resection even when large in size, bringing excellent long‐term outcomes. [ABSTRACT FROM AUTHOR]

A 45-year-old man from Pakistan presented with two raised and nodular plaques on his left arm that had been present since birth. He habitually scratched the lesions. The patient had no relevant medical history and denied contact with animals or recent travel. Biopsies revealed granulomatous inflammation, and further testing confirmed the presence of Mycobacterium tuberculosis (Mtb). The patient received antituberculosis therapy, leading to significant improvement in the skin lesions. This case highlights the importance of considering cutaneous Mtb in cases of chronic lesions with non-necrotizing granulomas and emphasizes the need for tissue culture to confirm the diagnosis and initiate prompt treatment. [Extracted from the article]

Fusarium is a polyphyletic genus of plant pathogens, members of which can cause opportunistic human infections with varying superficial and systemic presentations, including disseminated infections which typically occur in immunocompromised patients and have a poor prognosis. Treatment is challenging due to intrinsic resistance to many antifungal agents, and antifungal susceptibility testing is therefore essential. Early suspicion, isolation of the organism, and prompt initiation of management are crucial to improving survival. We present a case of disseminated Bisifusarium infection following toxic epidermal necrolysis in a child with B-cell acute lymphoblastic leukemia, successfully treated with liposomal amphotericin B, voriconazole, flucytosine, and terbinafine. [ABSTRACT FROM AUTHOR]