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2. A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery

Author

Jeremiasse, Bernadette, van Ineveld, Ravian L, Bok, Veerle, Kleinnijenhuis, Michiel, de Blank, Sam, Alieva, Maria, Johnson, Hannah R, van Vliet, Esmée J, Zeeman, Amber L, Wellens, Lianne M, Llibre-Palomar, Gerard, Barrera Román, Mario, Di Maggio, Alessia, Dekkers, Johanna F, Oliveira, Sabrina, Vahrmeijer, Alexander L, Molenaar, Jan J, Wijnen, Marc HWA, van der Steeg, Alida FW, Wehrens, Ellen J, and Rios, Anne C

Published
2024
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8. Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

Author

Wienke, Judith, Visser, Lindy L., Kholosy, Waleed M., Keller, Kaylee M., Barisa, Marta, Poon, Evon, Munnings-Tomes, Sophie, Himsworth, Courtney, Calton, Elizabeth, Rodriguez, Ana, Bernardi, Ronald, van den Ham, Femke, van Hooff, Sander R., Matser, Yvette A.H., Tas, Michelle L., Langenberg, Karin P.S., Lijnzaad, Philip, Borst, Anne L., Zappa, Elisa, Bergsma, Francisca J., Strijker, Josephine G.M., Verhoeven, Bronte M., Mei, Shenglin, Kramdi, Amira, Restuadi, Restuadi, Sanchez-Bernabeu, Alvaro, Cornel, Annelisa M., Holstege, Frank C.P., Gray, Juliet C., Tytgat, Godelieve A.M., Scheijde-Vermeulen, Marijn A., Wijnen, Marc H.W.A., Dierselhuis, Miranda P., Straathof, Karin, Behjati, Sam, Wu, Wei, Heck, Albert J.R., Koster, Jan, Nierkens, Stefan, Janoueix-Lerosey, Isabelle, de Krijger, Ronald R., Baryawno, Ninib, Chesler, Louis, Anderson, John, Caron, Hubert N., Margaritis, Thanasis, van Noesel, Max M., and Molenaar, Jan J.

Published
2024
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21. mRNA Expression Level of ALK in Neuroblastoma Is Associated with Histological Subtype, ALK Mutations and ALK Immunohistochemical Protein Expression.

Author

Bruinsma, Rixt S., Fiocco, Marta F., de Leng, Wendy W. J., Kester, Lennart A., Langenberg, Karin P. S., Tytgat, Godelieve A. M., van Noesel, Max M., Wijnen, Marc H. W. A., van der Steeg, Alida F. W., and de Krijger, Ronald R.

Subjects
NEUROBLASTOMA, PROTEIN expression, TRANSCRIPTOMES, SINGLE nucleotide polymorphisms, IMMUNOHISTOCHEMISTRY
Abstract

ALK is related to poor survival in neuroblastoma patients. We investigated the prognostic relevance of ALK mRNA expression and the relationship with ALK immunohistochemical expression, histological subtype and ALK aberrations. Whole transcriptome sequencing data were available from 54 patients. Overall survival (OS) and event-free survival (EFS) were estimated with Kaplan–Meier's methodology. ALK protein expression was analyzed by immunohistochemistry. ALK aberrations were detected using whole exome sequencing, single nucleotide polymorphism array, next generation sequencing and/or fluorescence in situ hybridization. OS was 74.8% and EFS was 60%. ALK mRNA expression was not associated with OS (HR 1.127, 95% CI (0.812–1.854), p = 0.331) and adjusted EFS (HR 1.134, 95% CI (0.783–1.644), p = 0.505), but was associated with histological subtype (OR 1.914, 95% CI (1.083–3.382), p = 0.025) and ALK protein expression (negative versus weak: OR 2.829, 95% CI (1.290–6.204), p = 0.009) (negative versus moderate/strong: OR 2.934, 95% CI (0.889–9.679), p = 0.077). ALK mutated tumors had significantly higher ALK mRNA expression than non-mutated tumors (p < 0.001). MYCN-amplified neuroblastomas have higher MYCN mRNA expression (p ≤ 0.001), but not ALK mRNA expression (p = 0.553). ALK mRNA expression is higher in ALK mutated neuroblastomas and is associated with poorer differentiation degree and higher protein expression. ALK mRNA expression is not significantly associated with OS and EFS. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Malignant extracranial germ cell tumors in the Netherlands between 1990-2018: stable incidence and improved survival

Author

Hulsker, Caroline C C, primary, Schulpen, Maya, additional, Mavinkurve-Groothuis, Annelies M C, additional, Visser, Otto, additional, Zsiros, József, additional, Wijnen, Marc H W, additional, de Krijger, Ronald R, additional, Bruggink, Annette H, additional, Looijenga, Leendert H J, additional, Karim-Kos, Henrike E., additional, and van der Steeg, Alida F W, additional

Published
2024
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24. Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

Author

Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Afd Pharmaceutics, Biomolecular Mass Spectrometry and Proteomics, Pharmaceutics, Wienke, Judith, Visser, Lindy L, Kholosy, Waleed M, Keller, Kaylee M, Barisa, Marta, Poon, Evon, Munnings-Tomes, Sophie, Himsworth, Courtney, Calton, Elizabeth, Rodriguez, Ana, Bernardi, Ronald, van den Ham, Femke, van Hooff, Sander R, Matser, Yvette A H, Tas, Michelle L, Langenberg, Karin P S, Lijnzaad, Philip, Borst, Anne L, Zappa, Elisa, Bergsma, Francisca J, Strijker, Josephine G M, Verhoeven, Bronte M, Mei, Shenglin, Kramdi, Amira, Restuadi, Restuadi, Sanchez-Bernabeu, Alvaro, Cornel, Annelisa M, Holstege, Frank C P, Gray, Juliet C, Tytgat, Godelieve A M, Scheijde-Vermeulen, Marijn A, Wijnen, Marc H W A, Dierselhuis, Miranda P, Straathof, Karin, Behjati, Sam, Wu, Wei, Heck, Albert J R, Koster, Jan, Nierkens, Stefan, Janoueix-Lerosey, Isabelle, de Krijger, Ronald R, Baryawno, Ninib, Chesler, Louis, Anderson, John, Caron, Hubert N, Margaritis, Thanasis, van Noesel, Max M, Molenaar, Jan J, Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Afd Pharmaceutics, Biomolecular Mass Spectrometry and Proteomics, Pharmaceutics, Wienke, Judith, Visser, Lindy L, Kholosy, Waleed M, Keller, Kaylee M, Barisa, Marta, Poon, Evon, Munnings-Tomes, Sophie, Himsworth, Courtney, Calton, Elizabeth, Rodriguez, Ana, Bernardi, Ronald, van den Ham, Femke, van Hooff, Sander R, Matser, Yvette A H, Tas, Michelle L, Langenberg, Karin P S, Lijnzaad, Philip, Borst, Anne L, Zappa, Elisa, Bergsma, Francisca J, Strijker, Josephine G M, Verhoeven, Bronte M, Mei, Shenglin, Kramdi, Amira, Restuadi, Restuadi, Sanchez-Bernabeu, Alvaro, Cornel, Annelisa M, Holstege, Frank C P, Gray, Juliet C, Tytgat, Godelieve A M, Scheijde-Vermeulen, Marijn A, Wijnen, Marc H W A, Dierselhuis, Miranda P, Straathof, Karin, Behjati, Sam, Wu, Wei, Heck, Albert J R, Koster, Jan, Nierkens, Stefan, Janoueix-Lerosey, Isabelle, de Krijger, Ronald R, Baryawno, Ninib, Chesler, Louis, Anderson, John, Caron, Hubert N, Margaritis, Thanasis, van Noesel, Max M, and Molenaar, Jan J

Published
2024

25. Introducing new dimensions in pediatric oncologic surgery

Author

DHS 3D Lab, Wijnen, Marc, van den Heuvel-Eibrink, Marry, van der Steeg, Lideke, Littooij, Annemieke, Fitski, M, DHS 3D Lab, Wijnen, Marc, van den Heuvel-Eibrink, Marry, van der Steeg, Lideke, Littooij, Annemieke, and Fitski, M

Published
2024

26. Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

Author

CTI Nierkens, Cancer, Infection & Immunity, CTI Research, Pathologie Pathologen staf, Onderzoek Beeld, Wienke, Judith, Visser, Lindy L, Kholosy, Waleed M, Keller, Kaylee M, Barisa, Marta, Poon, Evon, Munnings-Tomes, Sophie, Himsworth, Courtney, Calton, Elizabeth, Rodriguez, Ana, Bernardi, Ronald, van den Ham, Femke, van Hooff, Sander R, Matser, Yvette A H, Tas, Michelle L, Langenberg, Karin P S, Lijnzaad, Philip, Borst, Anne L, Zappa, Elisa, Bergsma, Francisca J, Strijker, Josephine G M, Verhoeven, Bronte M, Mei, Shenglin, Kramdi, Amira, Restuadi, Restuadi, Sanchez-Bernabeu, Alvaro, Cornel, Annelisa M, Holstege, Frank C P, Gray, Juliet C, Tytgat, Godelieve A M, Scheijde-Vermeulen, Marijn A, Wijnen, Marc H W A, Dierselhuis, Miranda P, Straathof, Karin, Behjati, Sam, Wu, Wei, Heck, Albert J R, Koster, Jan, Nierkens, Stefan, Janoueix-Lerosey, Isabelle, de Krijger, Ronald R, Baryawno, Ninib, Chesler, Louis, Anderson, John, Caron, Hubert N, Margaritis, Thanasis, van Noesel, Max M, Molenaar, Jan J, CTI Nierkens, Cancer, Infection & Immunity, CTI Research, Pathologie Pathologen staf, Onderzoek Beeld, Wienke, Judith, Visser, Lindy L, Kholosy, Waleed M, Keller, Kaylee M, Barisa, Marta, Poon, Evon, Munnings-Tomes, Sophie, Himsworth, Courtney, Calton, Elizabeth, Rodriguez, Ana, Bernardi, Ronald, van den Ham, Femke, van Hooff, Sander R, Matser, Yvette A H, Tas, Michelle L, Langenberg, Karin P S, Lijnzaad, Philip, Borst, Anne L, Zappa, Elisa, Bergsma, Francisca J, Strijker, Josephine G M, Verhoeven, Bronte M, Mei, Shenglin, Kramdi, Amira, Restuadi, Restuadi, Sanchez-Bernabeu, Alvaro, Cornel, Annelisa M, Holstege, Frank C P, Gray, Juliet C, Tytgat, Godelieve A M, Scheijde-Vermeulen, Marijn A, Wijnen, Marc H W A, Dierselhuis, Miranda P, Straathof, Karin, Behjati, Sam, Wu, Wei, Heck, Albert J R, Koster, Jan, Nierkens, Stefan, Janoueix-Lerosey, Isabelle, de Krijger, Ronald R, Baryawno, Ninib, Chesler, Louis, Anderson, John, Caron, Hubert N, Margaritis, Thanasis, van Noesel, Max M, and Molenaar, Jan J

Published
2024

28. The applicability of the central line‐associated bloodstream infection (CLABSI) criteria for the evaluation of bacteremia episodes in pediatric oncology patients.

Author

van den Bosch, Ceder H., Frakking, Florine N. J., Loeffen, Yvette G. T., van Tinteren, Harm, van der Steeg, Alida F. W., Wijnen, Marc H. W. A., van de Wetering, Marianne D., and van der Bruggen, Jan‐Tom

Subjects
CENTRAL line-associated bloodstream infections, PEDIATRIC oncology, MUCOSITIS, CANCER patients, BACTEREMIA, CENTRAL venous catheters
Abstract

Background: The aim of this study was to investigate the applicability of the central line‐associated bloodstream infection (CLABSI) criteria of the Centers for Disease Control and Prevention in pediatric oncology patients. Methods: Bacteremia episodes from 2020 to 2022 from a prospective cohort of pediatric oncology patients with a central venous catheter were included. Episodes were classified by three medical experts following the CLABSI criteria as either a CLABSI or non‐CLABSI (i.e., contamination, other infection source, or mucosal barrier injury‐laboratory confirmed bloodstream infection (MBI‐LCBI)). Subsequently, they were asked if and why they (dis)agreed with this diagnosis following the criteria. The primary outcome was the percentage of episodes where the experts clinically disagreed with the diagnosis given following the CLABSI criteria. Results: Overall, 84 bacteremia episodes in 71 patients were evaluated. Following the CLABSI criteria, 34 (40%) episodes were classified as CLABSIs and 50 (60%) as non‐CLABSIs. In 11 (13%) cases the experts clinically disagreed with the diagnosis following the CLABSI criteria. The discrepancy between the CLABSI criteria and clinical diagnosis was significant; McNemar's test p <.01. Disagreement by the experts with the CLABSI criteria mostly occurred when the experts found an MBI‐LCBI a more plausible cause of the bacteremia than a CLABSI due to the presence of a gram negative bacteremia (Pseudomonas aeruginosa n = 3) and/or mucositis. Conclusions: A discrepancy between the CLABSI criteria and the evaluation of the experts was observed. Adding Pseudomonas aeruginosa as an MBI pathogen and incorporating the presence of mucositis in the MBI‐LCBI criteria, might increase the applicability. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program ‘iTHER’

Author

Langenberg, Karin P.S., Meister, Michael T., Bakhuizen, Jette J., Boer, Judith M., van Eijkelenburg, Natasha K.A., Hulleman, Esther, Ilan, Uri, Looze, Eleonora J., Dierselhuis, Miranda P., van der Lugt, Jasper, Breunis, Willemijn, Schild, Linda G., Ober, Kimberley, van Hooff, Sander R., Scheijde-Vermeulen, Marijn A., Hiemcke-Jiwa, Laura S., Flucke, Uta E., Kranendonk, Mariette E.G., Wesseling, Pieter, Sonneveld, Edwin, Punt, Simone, Boltjes, Arjan, van Dijk, Freerk, Verwiel, Eugene T.P., Volckmann, Richard, Hehir-Kwa, Jayne Y., Kester, Lennart A., Koudijs, Marco M.J., Waanders, Esme, Holstege, Frank C.P., Vormoor, H. Josef, Hoving, Eelco W., van Noesel, Max M., Pieters, Rob, Kool, Marcel, Stumpf, Miriam, Blattner-Johnson, Mirjam, Balasubramanian, Gnana P., Van Tilburg, Cornelis M., Jones, Barbara C., Jones, David T.W., Witt, Olaf, Pfister, Stefan M., Jongmans, Marjolijn C.J., Kuiper, Roland P., de Krijger, Ronald R., Wijnen, Marc H.W., den Boer, Monique L., Zwaan, C. Michel, Kemmeren, Patrick, Koster, Jan, Tops, Bastiaan B.J., Goemans, Bianca F., Molenaar, Jan J., Dep Scheikunde, Afd Pharmaceutics, Pharmaceutics, Dep Scheikunde, Afd Pharmaceutics, Pharmaceutics, Center of Experimental and Molecular Medicine, Oncogenomics, and CCA - Cancer Treatment and Quality of Life

Subjects
Cancer Research, Adolescent, Molecular biology, Precision medicine, High-Throughput Nucleotide Sequencing, Medical Oncology, Hereditary, Oncology, Neoplasms, Mutation, Exome Sequencing, Next-generation sequencing, Humans, Molecular targeted therapy, Prospective Studies, Child, Cancer
Abstract

iTHER is a Dutch prospective national precision oncology program aiming to define tumour molecular profiles in children and adolescents with primary very high-risk, relapsed, or refractory paediatric tumours. Between April 2017 and April 2021, 302 samples from 253 patients were included. Comprehensive molecular profiling including low-coverage whole genome sequencing (lcWGS), whole exome sequencing (WES), RNA sequencing (RNA-seq), Affymetrix, and/or 850k methylation profiling was successfully performed for 226 samples with at least 20% tumour content. Germline pathogenic variants were identified in 16% of patients (35/219), of which 22 variants were judged causative for a cancer predisposition syndrome. At least one somatic alteration was detected in 204 (90.3%), and 185 (81.9%) were considered druggable, with clinical priority very high (6.1%), high (21.3%), moderate (26.0%), intermediate (36.1%), and borderline (10.5%) priority. iTHER led to revision or refinement of diagnosis in 8 patients (3.5%). Temporal heterogeneity was observed in paired samples of 15 patients, indicating the value of sequential analyses. Of 137 patients with follow-up beyond twelve months, 21 molecularly matched treatments were applied in 19 patients (13.9%), with clinical benefit in few. Most relevant barriers to not applying targeted therapies included poor performance status, as well as limited access to drugs within clinical trial. iTHER demonstrates the feasibility of comprehensive molecular profiling across all ages, tumour types and stages in paediatric cancers, informing of diagnostic, prognostic, and targetable alterations as well as reportable germline variants. Therefore, WES and RNA-seq is nowadays standard clinical care at the Princess Máxima Center for all children with cancer, including patients at primary diagnosis. Improved access to innovative treatments within biology-driven combination trials is required to ultimately improve survival.

Published
2022

32. Evaluation of Potential Targets for Fluorescence-Guided Surgery in Pediatric Ewing Sarcoma: A Preclinical Proof-of-Concept Study

Author

Jeremiasse, Bernadette, primary, Rijs, Zeger, additional, Angoelal, Karieshma R., additional, Hiemcke-Jiwa, Laura S., additional, de Boed, Ella A., additional, Kuppen, Peter J. K., additional, Sier, Cornelis F. M., additional, van Driel, Pieter B. A. A., additional, van de Sande, Michiel A. J., additional, Wijnen, Marc H. W. A., additional, Rios, Anne C., additional, and van der Steeg, Alida F. W., additional

Published
2023
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33. Anti-GD2-IRDye800CW as a targeted probe for fluorescence-guided surgery in neuroblastoma

Author

Wellens, Lianne M., Deken, Marion M., Sier, Cornelis F. M., Johnson, Hannah R., de la Jara Ortiz, Fàtima, Bhairosingh, Shadhvi S., Houvast, Ruben D., Kholosy, Waleed M., Baart, Victor M., Pieters, Annique M. M. J., de Krijger, Ronald R., Molenaar, Jan J., Wehrens, Ellen J., Dekkers, Johanna F., Wijnen, Marc H. W. A., Vahrmeijer, Alexander L., and Rios, Anne C.

Published
2020
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35. CATERPILLAR-study protocol: an assessor-blinded randomised controlled trial comparing taurolidine-citrate-heparin to heparin-only lock solutions for the prevention of central line-associated bloodstream infections in paediatric oncology patients

Author

van den Bosch, Ceder Hildegard, primary, Loeffen, Yvette, additional, van der Steeg, Alida F W, additional, van der Bruggen, Jan-Tom T, additional, Frakking, Florine N J, additional, Fiocco, Marta, additional, van de Ven, Cornelis P, additional, Wijnen, Marc H W A, additional, and van de Wetering, Marianne D, additional

Published
2023
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36. Radiologic versus Segmentation Measurements to Quantify Wilms Tumor Volume on MRI in Pediatric Patients

Author

Buser, Myrthe A.D., van der Steeg, Alida F.W., Wijnen, Marc H.W.A., Fitski, Matthijs, van Tinteren, Harm, van den Heuvel-Eibrink, Marry M., Littooij, Annemieke S., van der Velden, Bas H.M., Buser, Myrthe A.D., van der Steeg, Alida F.W., Wijnen, Marc H.W.A., Fitski, Matthijs, van Tinteren, Harm, van den Heuvel-Eibrink, Marry M., Littooij, Annemieke S., and van der Velden, Bas H.M.

Abstract

Wilms tumor is a common pediatric solid tumor. To evaluate tumor response to chemotherapy and decide whether nephron-sparing surgery is possible, tumor volume measurements based on magnetic resonance imaging (MRI) are important. Currently, radiological volume measurements are based on measuring tumor dimensions in three directions. Manual segmentation-based volume measurements might be more accurate, but this process is time-consuming and user-dependent. The aim of this study was to investigate whether manual segmentation-based volume measurements are more accurate and to explore whether these segmentations can be automated using deep learning. We included the MRI images of 45 Wilms tumor patients (age 0–18 years). First, we compared radiological tumor volumes with manual segmentation-based tumor volume measurements. Next, we created an automated segmentation method by training a nnU-Net in a five-fold cross-validation. Segmentation quality was validated by comparing the automated segmentation with the manually created ground truth segmentations, using Dice scores and the 95th percentile of the Hausdorff distances (HD95). On average, manual tumor segmentations result in larger tumor volumes. For automated segmentation, the median dice was 0.90. The median HD95 was 7.2 mm. We showed that radiological volume measurements underestimated tumor volume by about 10% when compared to manual segmentation-based volume measurements. Deep learning can potentially be used to replace manual segmentation to benefit from accurate volume measurements without time and observer constraints.

Published
2023

37. The results of concentration of care:Surgical outcomes of neuroblastoma in the Netherlands

Author

van der Steeg, Alida F.W., Jans, Merel, Tytgat, Godelieve, Fiocco, Marta F., van de Ven, Cornelis, Terwisscha van Scheltinga, Cecilia E.J., Pieters, Rob, van Noesel, Max M., van Dijk, Anton H., Hulsker, Caroline C.C., Wijnen, Marc H.W.A., van der Steeg, Alida F.W., Jans, Merel, Tytgat, Godelieve, Fiocco, Marta F., van de Ven, Cornelis, Terwisscha van Scheltinga, Cecilia E.J., Pieters, Rob, van Noesel, Max M., van Dijk, Anton H., Hulsker, Caroline C.C., and Wijnen, Marc H.W.A.

Abstract

Introduction. In the Netherlands pediatric oncological care for solid tumours is concentrated in one centre since November 2014. One of the most frequently diagnosed solid non-brain tumours in children is the neuroblastoma. Results of surgical treatment of neuroblastoma since the start of this centralization are presented and compared to a historic cohort. Methods. The new national cohort of neuroblastoma (n = 111) consists of all consecutive patients treated between January 1st, 2015 and April 1st, 2021. The historic neuroblastoma cohort consists of all operated neuroblastoma patients in the Netherlands between 1998 and 2014 (n = 244). Intra-operative complications and surgical outcome were registered. Post-operative complications were divided in short (<30 days after surgery) and long term (>30 days). The severity of complications was graded using the Clavien Dindo Classification (CDC) system. Results. Intraoperative outcomes showed significant differences in favour of the new cohort with less blood loss (p < 0.001), fewer vascular complications (p < 0.001) and shorter duration of surgery (p < 0.001). Short term complications were comparable in numbers, but significantly more patients had CDC grade 3/4/5 complications in the historic cohort (p = 0.005). Long term complications did not differ. Estimated overall survival showed a better survival in the new cohort (log rank 0.022). Conclusion. Centralization of care for neuroblastoma patients has led to a significant improvement of both intraoperative outcomes and short term complications.

Published
2023

38. CATERPILLAR-study protocol: an assessor-blinded randomised controlled trial comparing taurolidine-citrate-heparin to heparin-only lock solutions for the prevention of central line-associated bloodstream infections in paediatric oncology patients

Author

Infectieziekten patientenzorg, Infection & Immunity, MMB Zorg, Zorgeenheid Kinderchirurgie Medisch, Cancer, KinderComfortTeam, van den Bosch, Ceder Hildegard, Loeffen, Yvette, van der Steeg, Alida F W, van der Bruggen, Jan-Tom T, Frakking, Florine N J, Fiocco, Marta, van de Ven, Cornelis P, Wijnen, Marc H W A, van de Wetering, Marianne D, Infectieziekten patientenzorg, Infection & Immunity, MMB Zorg, Zorgeenheid Kinderchirurgie Medisch, Cancer, KinderComfortTeam, van den Bosch, Ceder Hildegard, Loeffen, Yvette, van der Steeg, Alida F W, van der Bruggen, Jan-Tom T, Frakking, Florine N J, Fiocco, Marta, van de Ven, Cornelis P, Wijnen, Marc H W A, and van de Wetering, Marianne D

Published
2023

39. Sentinel Lymph Node Procedure in Pediatric Patients with Melanoma, Squamous Cell Carcinoma, or Sarcoma Using Near-Infrared Fluorescence Imaging with Indocyanine Green: A Feasibility Trial

Author

MS Radiologie, Brain, Cancer, Zorgeenheid Kinderchirurgie Medisch, Jeremiasse, Bernadette, van Scheltinga, Cecilia E J Terwisscha, Smeele, Ludwig E, Tolboom, Nelleke, Wijnen, Marc H W A, van der Steeg, Alida F W, MS Radiologie, Brain, Cancer, Zorgeenheid Kinderchirurgie Medisch, Jeremiasse, Bernadette, van Scheltinga, Cecilia E J Terwisscha, Smeele, Ludwig E, Tolboom, Nelleke, Wijnen, Marc H W A, and van der Steeg, Alida F W

Published
2023

40. Radiologic versus Segmentation Measurements to Quantify Wilms Tumor Volume on MRI in Pediatric Patients

Author

Zorgeenheid Kinderchirurgie Medisch, Cancer, Speerpunt, Child Health, Zorg en O&O, MS Radiologie, Beeldverwerking ISI, Buser, Myrthe A D, van der Steeg, Alida F W, Wijnen, Marc H W A, Fitski, Matthijs, van Tinteren, Harm, van den Heuvel-Eibrink, Marry M, Littooij, Annemieke S, van der Velden, Bas H M, Zorgeenheid Kinderchirurgie Medisch, Cancer, Speerpunt, Child Health, Zorg en O&O, MS Radiologie, Beeldverwerking ISI, Buser, Myrthe A D, van der Steeg, Alida F W, Wijnen, Marc H W A, Fitski, Matthijs, van Tinteren, Harm, van den Heuvel-Eibrink, Marry M, Littooij, Annemieke S, and van der Velden, Bas H M

Published
2023

41. The results of concentration of care: Surgical outcomes of neuroblastoma in the Netherlands

Author

PMC Research, Zorgeenheid Kinderchirurgie Medisch, PMC Medisch specialisten, Cancer, Child Health, Zorg en O&O, Onderzoek Beeld, MS Neonatologie, van der Steeg, Alida F.W., Jans, Merel, Tytgat, Godelieve, Fiocco, Marta F., van de Ven, Cornelis, Terwisscha van Scheltinga, Cecilia E.J., Pieters, Rob, van Noesel, Max M., van Dijk, Anton H., Hulsker, Caroline C.C., Wijnen, Marc H.W.A., PMC Research, Zorgeenheid Kinderchirurgie Medisch, PMC Medisch specialisten, Cancer, Child Health, Zorg en O&O, Onderzoek Beeld, MS Neonatologie, van der Steeg, Alida F.W., Jans, Merel, Tytgat, Godelieve, Fiocco, Marta F., van de Ven, Cornelis, Terwisscha van Scheltinga, Cecilia E.J., Pieters, Rob, van Noesel, Max M., van Dijk, Anton H., Hulsker, Caroline C.C., and Wijnen, Marc H.W.A.

Published
2023

42. Direct correlation of MRI with histopathology in pediatric renal tumors through the use of a patient-specific 3-D-printed cutting guide: a feasibility study

Author

Onderzoek Beeld, Cancer, Pathologie Pathologen staf, Zorgeenheid Kinderchirurgie Medisch, Child Health, MS Radiologie, van der Beek, Justine N., Fitski, Matthijs, de Krijger, Ronald R., Wijnen, Marc H.W.A., van den Heuvel-Eibrink, Marry M., Vermeulen, Marijn A., van der Steeg, Alida F.W., Littooij, Annemieke S., Onderzoek Beeld, Cancer, Pathologie Pathologen staf, Zorgeenheid Kinderchirurgie Medisch, Child Health, MS Radiologie, van der Beek, Justine N., Fitski, Matthijs, de Krijger, Ronald R., Wijnen, Marc H.W.A., van den Heuvel-Eibrink, Marry M., Vermeulen, Marijn A., van der Steeg, Alida F.W., and Littooij, Annemieke S.

Published
2023

45. Evaluation of multiparametric MRI for deep learning-based segmentation of Wilms tumor

Author

Buser, Myrthe A., Wijnen, Marc H.W.A., van der Steeg, Alida F.W., van der Velden, Bas H.M., Chen, Yan, and Mello-Thoms, Claudia R.

Subjects
Life Science
Abstract

Deep learning techniques to segment Wilms tumor typically use a single MRI sequence as input. The aim of this study was to assess whether multiparametric MRI input improves Wilms tumor segmentation. 45 patients were consecutively included, of which 36 were used for training and nine for testing. All seven input combinations of postcontrast T1-weighted imaging, T2-weighted imaging, and diffusion weighted imaging (DWI) were used for nnU-Net training. Dice scores and the 95th percentile of the Haussdorf distance (HD95) were used to evaluate the input combinations. The median Dice score was highest when combining all MRI sequences (Dice = 0.93), the median HD95 was lowest when combining postcontrast T1-weighted imaging and DWI (HD95 = 5.4 mm). Single-parametric DWI input performed significantly worse than other input combinations (median Dice = 0.64, median HD95 = 29.5 mm, p = 0.004). All other combinations, including standalone sequences, showed similar performance to each other. Our results suggest that adding sequences to standalone T1-weighted or T2-weighted imaging does not significantly improve segmentation results.

Published
2023

48. Direct correlation of MRI with histopathology in pediatric renal tumors through the use of a patient-specific 3-D-printed cutting guide: a feasibility study

Author

van der Beek, Justine N., primary, Fitski, Matthijs, additional, de Krijger, Ronald R., additional, Wijnen, Marc H. W. A., additional, van den Heuvel-Eibrink, Marry M., additional, Vermeulen, Marijn A., additional, van der Steeg, Alida F. W., additional, and Littooij, Annemieke S., additional

Published
2022
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50. Integrative analysis of neuroblastoma by single‐cell RNA sequencing identifies the NECTIN2‐TIGIT axis as a target for immunotherapy

Author

Wienke, Judith, primary, Visser, Lindy L, additional, Kholosy, Waleed M, additional, Keller, Kaylee M, additional, Barisa, Marta, additional, Munnings-Tomes, Sophie, additional, Carlton, Elizabeth, additional, Poon, Evon, additional, Rodriguez, Ana, additional, Bernardi, Ronald, additional, Van den Ham, Femke, additional, Van Hooff, Sander R, additional, Matser, Yvette A.H., additional, Tas, Michelle, additional, Langenberg, Karin P.S., additional, Lijnzaad, Philip, additional, Strijker, Josephine G.M., additional, Sanchez-Bernabeu, Alvaro, additional, Cornel, Annelisa M, additional, Holstege, Frank C.P., additional, Gray, Juliet C, additional, Tytgat, Lieve A.M., additional, De Krijger, Ronald, additional, Scheijde-Vermeulen, Marijn A, additional, Wijnen, Marc H.W.A., additional, Dierselhuis, Miranda P., additional, Straathof, Karin, additional, Behjati, Sam, additional, Wu, Wei, additional, Heck, Albert J.R., additional, Koster, Jan, additional, Nierkens, Stefan, additional, Chesler, Louis, additional, Anderson, John, additional, Caron, Hubert N, additional, Margaritis, Thanasis, additional, Van Noesel, Max M, additional, and Molenaar, Jan J, additional

Published
2022
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