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3. Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction

Author

Wildi, K., Singeisen, H., Twerenbold, R., Badertscher, P., Wussler, D., Klinkenberg, L.J.J., Meex, S.J.R., Nestelberger, T., Boeddinghaus, J., Miró, Ò., Martin-Sanchez, F.J., Morawiec, B., Muzyk, P., Parenica, J., Keller, D.I., Geigy, N., Potlukova, E., Sabti, Z., Kozhuharov, N., Puelacher, C., du Fay de Lavallaz, J., Rubini Gimenez, M., Shrestha, S., Marzano, G., Rentsch, K., Osswald, S., Reichlin, T., and Mueller, C.

Published
2018
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4. A Novel Speckle-Tracking Echocardiographic Parameter Assessing Left Ventricular Loading During VA ECMO in a Pre-clinical Model of Cardiogenic Shock

Author

Sato, K., primary, Heinsar, S., additional, Obonyo, N., additional, Wildi, K., additional, Liu, K., additional, Farah, S., additional, Ainola, C., additional, Sato, N., additional, Ijuin, S., additional, Ro, S. Kyun, additional, Fior, G., additional, Gandini, L., additional, Bouquet, M., additional, Wilson, E., additional, Passmore, M., additional, Hyslop, K., additional, Chan, J., additional, Platts, D., additional, Scalia, G., additional, Suen, J., additional, Bassi, G. Li, additional, and Fraser, J., additional

Published
2023
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5. Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis

Author

Li Bassi, G, Gibbons, K, Suen, J, Dalton, H, White, N, Corley, A, Shrapnel, S, Hinton, S, Forsyth, S, Laffey, J, Fan, E, Fanning, J, Panigada, M, Bartlett, R, Brodie, D, Burrell, A, Chiumello, D, Elhazmi, A, Esperatti, M, Grasselli, G, Hodgson, C, Ichiba, S, Luna, C, Marwali, E, Merson, L, Murthy, S, Nichol, A, Ogino, M, Pelosi, P, Torres, A, Ng, P, Fraser, J, Al-Dabbous, T, Alfoudri, H, Shamsah, M, Elapavaluru, S, Berg, A, Horn, C, Mayasi, Y, Schroll, S, Meyer, D, Velazco, J, Ploskanych, L, Fikes, W, Bagewadi, R, Dao, M, White, H, Ehlers, A, Shalabi-McGuire, M, Witt, T, Grazioli, L, Lorini, L, Grandin, E, Nunez, J, Reyes, T, Obriain, D, Hunter, S, Ramanan, M, Affleck, J, Veerendra, H, Rai, S, Russell-Brown, J, Nourse, M, Joseph, M, Mitchell, B, Tenzer, M, Abe, R, Cho, H, Jeong, I, Rahman, N, Kakar, V, Brozzi, N, Mehkri, O, Krishnan, S, Duggal, A, Houltham, S, Graf, J, Diaz, R, Orrego, R, Delgado, C, Gonzalez, J, Sanchez, M, Piagnerelli, M, Sarrazin, J, Zabert, A, Espinosa, L, Delgado, P, Delgado, V, Rincon, D, Yanten, A, Duque, M, Al-Hudaib, A, Callahan, M, Taufik, M, Wardoyo, E, Gunawan, M, Trisnaningrum, N, Irawany, V, Rayhan, M, Pesenti, A, Zanella, A, Leone, M, Coppola, S, Colombo, S, Antonelli, M, Carelli, S, Grieco, D, Asaki, M, Hoshino, K, Salazar, L, Duarte, L, Mcnicholas, B, Cosgrave, D, Mccaffrey, J, Bone, A, Hakeem, Y, Winearls, J, Tallott, M, Thomson, D, Arnold-Day, C, Cupido, J, Miller, M, Seymore, L, van Straaten, D, Hssain, A, Aliudin, J, Alqahtani, A, Mohamed, K, Mohamed, A, Tan, D, Villanueva, J, Zaqout, A, Kurtzman, E, Ademi, A, Dobrita, A, El Aoudi, K, Segura, J, Giwangkancana, G, Ohshimo, S, Hitoshi, S, Osatnik, J, Joosten, A, Yang, M, Motos, A, Arancibia, F, Williams, V, Noel, A, Luque, N, Trung, T, Yacoub, S, Fantini, M, Garcia, R, Alvarez, E, Greti, A, Ceccato, A, Sanchez, A, Vazquez, A, Roche-Campo, F, Franch-Llasat, D, Tuazon, D, Amato, M, Cassimiro, L, Pola, F, Ribeiro, F, Fonseca, G, Desai, M, Osborn, E, Deeb, H, Arcadipane, A, Martucci, G, Panarello, G, Vitiello, C, Bianco, C, Occhipinti, G, Rossetti, M, Cuffaro, R, Cho, S, Shimizu, H, Moriyama, N, Kim, J, Kitamura, N, Gebauer, J, Yokoyama, T, Al-Fares, A, Buabbas, S, Alamad, E, Alawadhi, F, Alawadi, K, Tanaka, H, Hashimoto, S, Yamazaki, M, Oh, T, Epler, M, Forney, C, Kruse, L, Feister, J, Williamson, J, Grobengieser, K, Gnall, E, Golden, S, Caroline, M, Shapiro, T, Karaj, C, Thome, L, Sher, L, Vanderland, M, Welch, M, Mcdermott, S, Brain, M, Mineall, S, Kimura, D, Brazzi, L, Sales, G, Ogston, T, Nagpal, D, Fischer, K, Lorusso, R, Rangappa, R, Appu, A, Carton, E, Sen, A, Palacios, A, Rainey, D, Samoukoviv, G, Campisi, J, Durham, L, Neumann, E, Seefeldt, C, Falcucci, O, Emmrich, A, Guy, J, Johns, C, Potzner, K, Zimmermann, C, Espinal, A, Buchtele, N, Schwameis, M, Stecher, S, Singh, D, Barnikel, M, Arenz, L, Zaaqoq, A, Galloway, L, Merley, C, Csete, M, Quesada, L, Saba, I, Kasugai, D, Hiraiwa, H, Tanaka, T, Purnama, Y, Dewayanti, S, Ardiyan, Juzar, D, Siagian, D, Chen, Y, Ratsep, I, Oigus, G, Erikson, K, Post, A, Enneveer, L, Sillaots, P, Manetta, F, Mihelis, E, Sarmiento, I, Narasimhan, M, Varrone, M, Komats, M, Garcia-Diaz, J, Harmon, C, Satyapriya, S, Bhatt, A, Mokadam, N, Uribe, A, Gonzalez, A, Shi, H, Mckeown, J, Pasek, J, Fiorda, J, Echeverria, M, Moreno, R, Zakhary, B, Cavana, M, Cucino, A, Foti, G, Giani, M, Russotto, V, Castagna, V, Dellamore, A, Navalesi, P, Shum, H, Vuysteke, A, Usman, A, Acker, A, Smood, B, Mergler, B, Sertic, F, Subramanian, M, Sperry, A, Rizer, N, Burhan, E, Rasmin, M, Akmal, E, Sitompul, F, Lolong, N, Naivedh, B, Erickson, S, Barrett, P, Dean, D, Daugherty, J, Loforte, A, Khan, I, Abraar Quraishi, M, Desantis, O, So, D, Kandamby, D, Mandei, J, Natanael, H, Yudhalantang, E, Lantang, A, Wijaya, S, Jung, A, Ng, G, Ng, W, Fang, S, Tabah, A, Ratcliffe, M, Duroux, M, Adachi, S, Nakao, S, Blanco, P, Prieto, A, Sanchez, J, Nicholson, M, Butt, W, Serratore, A, Delzoppo, C, Janin, P, Yarad, E, Totaro, R, Coles, J, Pujo, B, Balk, R, Vissing, A, Kapania, E, Hays, J, Fox, S, Yantosh, G, Mishin, P, Yuliarto, S, Hari Santoso, K, Djajalaksana, S, Fatoni, A, Fukuda, M, Liu, K, Battaglini, D, Jimenez, J, Bastos, D, Gaiao, S, Rusmawatiningtyas, D, Buchner, J, Cho, Y, Lee, S, Kawasaki, T, Munshi, L, Sakiyalak, P, Nitayavardhana, P, Seitz, T, Arora, R, Kent, D, Marino, D, Parwar, S, Cheng, A, Miller, J, Fujitani, S, Shimizu, N, Madhok, J, Owyang, C, Buscher, H, Reynolds, C, Maasikas, O, Beljantsev, A, Mihnovits, V, Akimoto, T, Aizawa, M, Horibe, K, Onodera, R, Young, M, George, T, Shekar, K, Mcguinness, N, Irvine, L, Flynn, B, Endo, T, Sugiyama, K, Shimizu, K, Exconde, K, Lussier, L, Lotz, G, Malfertheiner, M, Maier, L, Dreier, E, Kusumastuti, N, Mccloskey, C, Dabaliz, A, Elshazly, T, Smith, J, Szuldrzynski, K, Bielanski, P, Wille, K, Parhar, K, Fiest, K, Codan, C, Shahid, A, Fayed, M, Evans, T, Gutierrez, A, Song, T, Rose, R, Bennett, S, Richardson, D, Peek, G, Arora, L, Rappapport, K, Rudolph, K, Sibenaller, Z, Stout, L, Walter, A, Herr, D, Vedadi, N, Thompson, S, Sindt, L, Rajnic, S, Ewald, C, Hoffman, J, Ying, X, Kennedy, R, Griffee, M, Ciullo, A, Kida, Y, Roca, R, Riera, J, Contreras, S, Alegre, C, Kay, C, Fischer, I, Renner, E, Taniguci, H, Bassi, G, Barnett, A, Pearse, I, Abbate, G, Hassan, H, Heinsar, S, Karnik, V, Ki, K, Oneill, H, Obonyo, N, Pimenta, L, Reid, J, Sato, K, Vuorinen, A, Wildi, K, Wood, E, Yerkovich, S, Lee, J, Plotkin, D, Citarella, B, Hartley, E, Lubis, B, Ikeyama, T, Bhaskar, B, Jung, J, Mcguinness, S, Eastwood, G, Marta, S, Guarracino, F, Gerle, S, Coxon, E, Claro, B, Loverde, D, Patil, N, Parrini, V, Mcbride, A, Negaard, K, Ratsch, A, Abdelaziz, A, Uribe, J, Peris, A, Sanders, M, Emerson, D, Kamal, M, Povoa, P, Francis, R, Cherif, A, Joseph, S, Di Nardo, M, Heard, M, Kyle, K, Blackwell, R, Biston, P, Jeong, H, Smith, R, Prawira, Y, Montrucchio, G, Garcia, A, Salterain, N, Meyns, B, Moreno, M, Walia, R, Mehta, A, Schweda, A, Supriatna, M, Kirakli, C, Williams, M, Kim, K, Assad, A, Giraldo, E, Karolak, W, Balik, M, Pocock, E, Gajkowski, E, Masafumi, K, Barrett, N, Takeyama, Y, Park, S, Amin, F, Andriyani, F, Sudakevych, S, Vera, M, Cornejo, R, Schwarz, P, Mardini, A, de Paula, T, Neto, A, Villoldo, A, Colafranceschi, A, Iglesias, A, Granjean, J, Melro, L, Romualdo, G, Gaia, D, Souza, H, Galas, F, Mendiluce, R, Sosa, A, Martinez, I, Kurosawa, H, Salgado, J, Hugi-MayrCharbonneau, B, Barzilai, V, Monteiro, V, de Souza, R, Harper, M, Suzuki, H, Adams, C, Brieva, J, Nyale, G, Eltatar, F, Fatani, J, Baeissa, H, Masri, A, Rabie, A, Hui, M, Yamane, M, Jung, H, Margaret, A, Nacpil, N, Ruck, K, Bakken, R, Jara, C, Felton, T, Berra, L, Shah, B, Chakraborty, A, Cardona, M, Capatos, G, Akkanti, B, Orija, A, Jain, H, Ito, A, Housni, B, Low, S, Iihara, K, Chavez, J, Ramanathan, K, Zabert, G, Naidoo, K, Seppelt, I, Vandyk, M, Macdonald, S, Mcgregor, R, Siebenaler, T, Flynn, H, Lofton, K, Aokage, T, Shigemitsu, K, Moscatelli, A, Fiorentino, G, Baumgaertel, M, Mba, S, Assy, J, Hutahaean, A, Roush, H, Sichting, K, Alessandri, F, Burns, D, Salt, G, Garabedian, C, Millar, J, Sim, M, Mattke, A, Mcauley, D, Tadili, J, Frenzel, T, Bar-Lavie, Y, Ortiz, A, Stone, J, Attokaran, A, Farquharson, M, Patel, B, Gunning, D, Baillie, K, Watson, P, Tamai, K, Sajinadiyasa, G, Kanyawati, D, Salgado, M, Sassine, A, Yudo, B, Mccaul, S, Lee, B, Afek, A, Iwashita, Y, Semedi, B, Metiva, J, Van Belle, N, Martin-Loeches, I, Ivatt, L, Woon, C, Kang, H, Smith, T, James, E, Al-Rawas, N, Iwasaki, Y, King-Chung, K, Gudzenko, V, Hugi-Mayr, B, Taccone, F, Perdhana, F, Lamarche, Y, Ribeiro, J, Bradic, N, Van den Bossche, K, Lansink, O, Singh, G, Debeuckelaere, G, Stelfox, H, Yi, C, Elia, J, Tribble, T, Shankar, S, Padmanabhan, R, Hallinan, B, Paoletti, L, Leyva, Y, Fykuda, T, Badulak, J, Koch, J, Hackman, A, Janowaik, L, Hernandez, D, Osofsky, J, Donadello, K, Lawang, A, Fine, J, Davidson, B, Li Bassi G., Gibbons K., Suen J. Y., Dalton H. J., White N., Corley A., Shrapnel S., Hinton S., Forsyth S., Laffey J. G., Fan E., Fanning J. P., Panigada M., Bartlett R., Brodie D., Burrell A., Chiumello D., Elhazmi A., Esperatti M., Grasselli G., Hodgson C., Ichiba S., Luna C., Marwali E., Merson L., Murthy S., Nichol A., Ogino M., Pelosi P., Torres A., Ng P. Y., Fraser J. F., Al-Dabbous T., Alfoudri H., Shamsah M., Elapavaluru S., Berg A., Horn C., Mayasi Y., Schroll S., Meyer D., Velazco J., Ploskanych L., Fikes W., Bagewadi R., Dao M., White H., Ehlers A., Shalabi-McGuire M., Witt T., Grazioli L., Lorini L., Grandin E. W., Nunez J., Reyes T., OBriain D., Hunter S., Ramanan M., Affleck J., Veerendra H. H., Rai S., Russell-Brown J., Nourse M., Joseph M., Mitchell B., Tenzer M., Abe R., Cho H. J., Jeong I. S., Rahman N., Kakar V., Brozzi N., Mehkri O., Krishnan S., Duggal A., Houltham S., Graf J., Diaz R., Orrego R., Delgado C., Gonzalez J., Sanchez M. S., Piagnerelli M., Sarrazin J. V., Zabert A. /P. G., Espinosa L., Delgado P., Delgado V., Rincon D. F. B., Yanten A. M. M., Duque M. B., Al-Hudaib A., Callahan M., Taufik M. A., Wardoyo E. Y., Gunawan M., Trisnaningrum N. S., Irawany V., Rayhan M., Pesenti A., Zanella A., Leone M., Coppola S., Colombo S., Antonelli M., Carelli S., Grieco D. L., Asaki M., Hoshino K., Salazar L., Duarte L., McNicholas B., Cosgrave D., McCaffrey J., Bone A., Hakeem Y., Winearls J., Tallott M., Thomson D., Arnold-Day C., Cupido J., Miller M., Seymore L., van Straaten D., Hssain A. A., Aliudin J., Alqahtani A. -R., Mohamed K., Mohamed A., Tan D., Villanueva J., Zaqout A., Kurtzman E., Ademi A., Dobrita A., El Aoudi K., Segura J., Giwangkancana G., Ohshimo S., Hitoshi S., Osatnik J., Joosten A., Yang M., Motos A., Arancibia F., Williams V., Noel A., Luque N., Trung T. H., Yacoub S., Fantini M., Garcia R. N. J., Alvarez E. C., Greti A., Ceccato A., Sanchez A., Vazquez A. L., Roche-Campo F., Franch-Llasat D., Tuazon D., Amato M., Cassimiro L., Pola F., Ribeiro F., Fonseca G., Dalton H., Desai M., Osborn E., Deeb H., Arcadipane A., Martucci G., Panarello G., Vitiello C., Bianco C., Occhipinti G., Rossetti M., Cuffaro R., Cho S. -M., Shimizu H., Moriyama N., Kim J. -B., Kitamura N., Gebauer J., Yokoyama T., Al-Fares A., Buabbas S., Alamad E., Alawadhi F., Alawadi K., Tanaka H., Hashimoto S., Yamazaki M., Oh T. -H., Epler M., Forney C., Kruse L., Feister J., Williamson J., Grobengieser K., Gnall E., Golden S., Caroline M., Shapiro T., Karaj C., Thome L., Sher L., Vanderland M., Welch M., McDermott S., Brain M., Mineall S., Kimura D., Brazzi L., Sales G., Ogston T., Nagpal D., Fischer K., Lorusso R., Rangappa R., Appu A., Carton E. G., Sen A., Palacios A., Rainey D., Samoukoviv G., Campisi J., Durham L., Neumann E., Seefeldt C., Falcucci O., Emmrich A., Guy J., Johns C., Potzner K., Zimmermann C., Espinal A., Buchtele N., Schwameis M., Stecher S. -S., Singh D., Barnikel M., Arenz L., Zaaqoq A., Galloway L. A., Merley C., Csete M., Quesada L., Saba I., Kasugai D., Hiraiwa H., Tanaka T., Purnama Y., Dewayanti S. R., Juzar D. A., Siagian D., Chen Y. -S., Ratsep I., Oigus G., Erikson K., Post A. -M., Enneveer L., Sillaots P., Manetta F., Mihelis E., Sarmiento I. C., Narasimhan M., Varrone M., Komats M., Garcia-Diaz J., Harmon C., Satyapriya S. V., Bhatt A., Mokadam N. A., Uribe A., Gonzalez A., Shi H., McKeown J., Pasek J., Fiorda J., Echeverria M., Moreno R., Zakhary B., Cavana M., Cucino A., Foti G., Giani M., Russotto V., Castagna V., DellAmore A., Navalesi P., Shum H. -P., Vuysteke A., Usman A., Acker A., Smood B., Mergler B., Sertic F., Subramanian M., Sperry A., Rizer N., Burhan E., Rasmin M., Akmal E., Sitompul F., Lolong N., Naivedh B., Erickson S., Barrett P., Dean D., Daugherty J., Loforte A., Khan I., Abraar Quraishi M., DeSantis O., So D., Kandamby D., Mandei J. M., Natanael H., YudhaLantang E., Lantang A., Wijaya S. O., Jung A., Ng G., Ng W. Y., Fang S., Tabah A., Ratcliffe M., Duroux M., Adachi S., Nakao S., Blanco P., Prieto A., Sanchez J., Nicholson M., Butt W., Serratore A., Delzoppo C., Janin P., Yarad E., Totaro R., Coles J., Pujo B., Balk R., Vissing A., Kapania E., Hays J., Fox S., Yantosh G., Mishin P., Yuliarto S., Hari Santoso K., Djajalaksana S., Fatoni A. Z., Fukuda M., Liu K., Battaglini D., Jimenez J. F. M., Bastos D., Gaiao S., Rusmawatiningtyas D., Buchner J., Cho Y. -J., Lee S. H., Kawasaki T., Munshi L., Sakiyalak P., Nitayavardhana P., Seitz T., Arora R., Kent D., Marino D., Parwar S., Cheng A., Miller J., Fujitani S., Shimizu N., Madhok J., Owyang C., Buscher H., Reynolds C., Maasikas O., Beljantsev A., Mihnovits V., Akimoto T., Aizawa M., Horibe K., Onodera R., Young M., George T., Shekar K., McGuinness N., Irvine L., Flynn B., Endo T., Sugiyama K., Shimizu K., Exconde K., Lussier L., Lotz G., Malfertheiner M., Maier L., Dreier E., Kusumastuti N. P., McCloskey C., Dabaliz A. -A., Elshazly T. B., Smith J., Szuldrzynski K. S., Bielanski P., Wille K., Parhar K. K. S., Fiest K. M., Codan C., Shahid A., Fayed M., Evans T., Garcia R., Gutierrez A., Song T., Rose R., Bennett S., Richardson D., Peek G., Arora L., Rappapport K., Rudolph K., Sibenaller Z., Stout L., Walter A., Herr D., Vedadi N., Thompson S., Sindt L., Rajnic S., Ewald C., Hoffman J., Ying X., Kennedy R., Griffee M., Ciullo A., Kida Y., Roca R. F., Riera J. I., Contreras S., Alegre C., Kay C., Fischer I., Renner E., Taniguci H., Bassi G. L., Suen J., Barnett A., Pearse I., Abbate G., Hassan H., Heinsar S., Karnik V. A., Ki K., ONeill H. F., Obonyo N., Pimenta L. P., Reid J. D., Sato K., Vuorinen A., Wildi K. S., Wood E. S., Yerkovich S., Lee J., Plotkin D., Citarella B. W., Hartley E., Lubis B., Ikeyama T., Bhaskar B., Jung J. -S., McGuinness S., Eastwood G., Marta S. R., Guarracino F., Gerle S., Coxon E., Claro B., Loverde D., Patil N., Parrini V., McBride A., Negaard K., Ratsch A., Abdelaziz A., Uribe J. D., Peris A., Sanders M., Emerson D., Kamal M., Povoa P., Francis R., Cherif A., Joseph S., Di Nardo M., Heard M., Kyle K., Blackwell R. A., Biston P., Jeong H. W., Smith R., Prawira Y., Montrucchio G., Garcia A. H., Salterain N., Meyns B., Moreno M., Walia R., Mehta A., Schweda A., Supriatna M., Kirakli C., Williams M., Kim K. H., Assad A., Giraldo E., Karolak W., Balik M., Pocock E., Gajkowski E., Masafumi K., Barrett N., Takeyama Y., Park S., Amin F., Andriyani F. M., Sudakevych S., Vera M., Cornejo R., Schwarz P., Mardini A. C., de Paula T., Neto A. S., Villoldo A., Colafranceschi A. S., Iglesias A. U., Granjean J., Melro L. M. G., Romualdo G. F., Gaia D., Souza H., Galas F., Mendiluce R. M., Sosa A., Martinez I., Kurosawa H., Salgado J., Hugi-MayrCharbonneau B. E., Barzilai V. S., Monteiro V., de Souza R. R., Harper M., Suzuki H., Adams C., Brieva J., Nyale G., Eltatar F. S., Fatani J., Baeissa H., Masri A. A., Rabie A., Hui M. Y., Yamane M., Jung H., Margaret A. M., Nacpil N., Ruck K., Bakken R., Jara C., Felton T., Berra L., Shah B., Chakraborty A., Cardona M., Capatos G., Akkanti B., Orija A., Jain H., Ito A., Housni B., Low S., Iihara K., Chavez J., Ramanathan K., Zabert G., Naidoo K., Seppelt I., VanDyk M., MacDonald S., McGregor R., Siebenaler T., Flynn H., Lofton K., Aokage T., Shigemitsu K., Moscatelli A., Fiorentino G., Baumgaertel M., Mba S. E., Assy J., Hutahaean A., Roush H., Sichting K. A., Alessandri F., Burns D., Salt G., Garabedian C. P., Millar J., Sim M., Mattke A., McAuley D., Tadili J., Frenzel T., Bar-Lavie Y., Ortiz A. B., Stone J., Attokaran A., Farquharson M., Patel B., Gunning D., Baillie K., Watson P., Tamai K., Sajinadiyasa G. K., Kanyawati D., Salgado M., Sassine A., Yudo B., McCaul S., Lee B., Lee S. M., Afek A., Iwashita Y., Semedi B. P., Metiva J., Van Belle N., Martin-Loeches I., Ivatt L., Woon C. Y., Kang H. M., Smith T., James E., Al-Rawas N., Iwasaki Y., King-Chung K. C., Gudzenko V., Hugi-Mayr B., Taccone F., Perdhana F., Lamarche Y., Ribeiro J. M., Bradic N., Van den Bossche K., Lansink O., Singh G., Debeuckelaere G., Stelfox H. T., Yi C., Elia J., Tribble T., Shankar S., Padmanabhan R., Hallinan B., Paoletti L., Leyva Y., Fykuda T., Badulak J., Koch J., Hackman A., Janowaik L., Hernandez D., Osofsky J., Donadello K., Lawang A., Fine J., Davidson B., Vazquez A. O. R., Li Bassi, G, Gibbons, K, Suen, J, Dalton, H, White, N, Corley, A, Shrapnel, S, Hinton, S, Forsyth, S, Laffey, J, Fan, E, Fanning, J, Panigada, M, Bartlett, R, Brodie, D, Burrell, A, Chiumello, D, Elhazmi, A, Esperatti, M, Grasselli, G, Hodgson, C, Ichiba, S, Luna, C, Marwali, E, Merson, L, Murthy, S, Nichol, A, Ogino, M, Pelosi, P, Torres, A, Ng, P, Fraser, J, Al-Dabbous, T, Alfoudri, H, Shamsah, M, Elapavaluru, S, Berg, A, Horn, C, Mayasi, Y, Schroll, S, Meyer, D, Velazco, J, Ploskanych, L, Fikes, W, Bagewadi, R, Dao, M, White, H, Ehlers, A, Shalabi-McGuire, M, Witt, T, Grazioli, L, Lorini, L, Grandin, E, Nunez, J, Reyes, T, Obriain, D, Hunter, S, Ramanan, M, Affleck, J, Veerendra, H, Rai, S, Russell-Brown, J, Nourse, M, Joseph, M, Mitchell, B, Tenzer, M, Abe, R, Cho, H, Jeong, I, Rahman, N, Kakar, V, Brozzi, N, Mehkri, O, Krishnan, S, Duggal, A, Houltham, S, Graf, J, Diaz, R, Orrego, R, Delgado, C, Gonzalez, J, Sanchez, M, Piagnerelli, M, Sarrazin, J, Zabert, A, Espinosa, L, 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Abstract

Background: The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods: We analyzed a convenience sample of patients with COVID-19 and moderate-to-severe ARDS, admitted to 244 intensive care units within the COVID-19 Critical Care Consortium, from February 1, 2020, through October 31, 2021. Patients undergoing at least 2 days and up to 3 consecutive days of NMBAs (NMBA treatment), within 48 h from commencement of IMV were compared with subjects who did not receive NMBAs or only upon commencement of IMV (control). The primary objective in the PS-matched cohort was comparison between groups in 90-day in-hospital mortality, assessed through Cox proportional hazard modeling. Secondary objectives were comparisons in the numbers of ventilator-free days (VFD) between day 1 and day 28 and between day 1 and 90 through competing risk regression. Results: Data from 1953 patients were included. After propensity score matching, 210 cases from each group were well matched. In the PS-matched cohort, mean (± SD) age was 60.3 ± 13.2 years and 296 (70.5%) were male and the most common comorbidities were hypertension (56.9%), obesity (41.1%), and diabetes (30.0%). The unadjusted hazard ratio (HR) for death at 90 days in the NMBA treatment vs control group was 1.12 (95% CI 0.79, 1.59, p = 0.534). After adjustment for smoking habit and critical therapeutic covariates, the HR was 1.07 (95% CI 0.72, 1.61, p = 0.729). At 28 days, VFD were 16 (IQR 0–25) and 25 (IQR 7–26) in the NMBA treatment and control groups, respectively (sub-hazard ratio 0.82, 95% CI 0.67, 1.00, p = 0.055). At 90 days, VFD were 77 (IQR 0–87) and 87 (IQR 0–88) (sub-hazard ratio 0.86 (95% CI 0.69, 1.07; p =

Published
2022

6. Use of copeptin and high-sensitive cardiac troponin T for diagnosis and prognosis in patients with diabetes mellitus and suspected acute myocardial infarction

Author

Zellweger, C., Wildi, K., Twerenbold, R., Reichlin, T., Naduvilekoot, A., Neuhaus, J.D., Balmelli, C., Gabutti, M., Al Afify, A., Ballarino, P., Jäger, C., Druey, S., Hillinger, P., Haaf, P., Vilaplana, C., Darbouret, B., Ebmeyer, S., Rubini Gimenez, M., Moehring, B., Osswald, S., and Mueller, C.

Published
2015
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7. 0/1h-algorithm using a new high-sensitivity cardiac troponin I assay for early diagnosis of myocardial infarction

Author

Koechlin, L, primary, Boeddinghaus, J, additional, Lopez-Ayala, P, additional, Nestelberger, T, additional, Wussler, D, additional, Twerenbold, R, additional, Zimmermann, T, additional, Wildi, K, additional, Miro, O, additional, Martin-Sanchez, J, additional, Keller, D, additional, Christ, M, additional, Buser, A, additional, Rubini Gimenez, M, additional, and Mueller, C, additional

Published
2022
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9. Performance of high-sensitivity cardiac troponin T versus I for the early diagnosis of myocardial infarction

Author

Koechlin, L, primary, Boeddinghaus, J, additional, Lopez-Ayala, P, additional, Nestelberger, T, additional, Miro, O, additional, Wussler, D, additional, Zimmermann, T, additional, Strebel, I, additional, Christ, M, additional, Wildi, K, additional, Rubini Gimenez, M, additional, Martin-Sanchez, J, additional, Keller, D, additional, Twerenbold, R, additional, and Mueller, C, additional

Published
2022
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11. Extending the no objective testing rules to patients triaged by the ESC 0/1-hour algorithms

Author

Boeddinghaus, J, primary, Ratmann, P D, additional, Nestelberger, T, additional, Lopez-Ayala, P, additional, Koechlin, L, additional, Wildi, K, additional, Miro, O, additional, Martin-Sanchez, J, additional, Christ, M, additional, Gualandro, D, additional, Rubini Gimenez, M, additional, Keller, D, additional, Buser, A, additional, and Mueller, C, additional

Published
2022
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12. Long-Term Impact in Intensive Care Survivors of Coronavirus Disease-19 (AFTERCOR Study): Preliminary 3-Month Analysis After ICU Discharge

Author

Wildi, K., primary, LiBassi, G., additional, McNicholas, B., additional, Rainieri, F., additional, Forsyth, S., additional, Cho, S.-M., additional, Motos, A., additional, Cabrera, R., additional, Barnett, A., additional, Panigada, M., additional, Colombo, S., additional, Matsuoka, A., additional, Ohshimo, S., additional, Bandera, A., additional, Laffey, J.G., additional, Muscatello, A., additional, Sheehan, J., additional, Battaglini, D., additional, Robba, C., additional, Torres, A., additional, Roche-Campo, F., additional, Luna, C.M., additional, Hodgson, C.L., additional, Burrell, A., additional, Buscher, H., additional, Salazar, L., additional, Mendoza Monsalve, M., additional, Chia, Y.W., additional, Dalton, H.J., additional, Choi, H.A., additional, Suen, J., additional, and Fraser, J., additional

Published
2022
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13. Early Clinical Improvement in ARDS Results from Selecting the Right Subphenotype for Anti-Inflammatory Treatment - a Preclinical Randomized Blinded Ovine Study

Author

Wildi, K., primary, Livingstone, S., additional, Ainola, C., additional, Colombo, S.M., additional, Heinsar, S., additional, Sato, N., additional, Sato, K., additional, Bouqet, M., additional, Wilson, E., additional, Abbate, G., additional, Passmore, M., additional, Hyslop, K., additional, Liu, K., additional, Palmieri, C., additional, Ki, K., additional, LiBassi, G., additional, Suen, J., additional, and Fraser, J., additional

Published
2022
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14. Preliminary Assessment of Respiratory System Elastance Following Nebulisation of Various Electrically Conductive Solutions

Author

Li Bassi, G., primary, Ainola, C., additional, Fior, G., additional, Liu, K., additional, Colombo, S., additional, Abbate, G., additional, Sato, K., additional, Sato, N., additional, McGuire, D., additional, Heinsar, S., additional, Livingstone, S., additional, Wildi, K., additional, Morais, C., additional, Passmore, M., additional, Wilson, E., additional, Boquet, M., additional, Torres, A., additional, Suen, J., additional, and Fraser, J., additional

Published
2022
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15. Recovery of organ-specific tissue oxygen delivery at restrictive transfusion thresholds after fluid treatment in ovine haemorrhagic shock

Author

Dyer, WB, Simonova, G, Chiaretti, S, Bouquet, M, Wellburn, R, Heinsar, S, Ainola, C, Wildi, K, Sato, K, Livingstone, S, Suen, JY, Irving, DO, Tung, J-P, li Bassi, G, Fraser, JF, Dyer, WB, Simonova, G, Chiaretti, S, Bouquet, M, Wellburn, R, Heinsar, S, Ainola, C, Wildi, K, Sato, K, Livingstone, S, Suen, JY, Irving, DO, Tung, J-P, li Bassi, G, and Fraser, JF

Abstract

BackgroundFluid resuscitation is the standard treatment to restore circulating blood volume and pressure after massive haemorrhage and shock. Packed red blood cells (PRBC) are transfused to restore haemoglobin levels. Restoration of microcirculatory flow and tissue oxygen delivery is critical for organ and patient survival, but these parameters are infrequently measured. Patient Blood Management is a multidisciplinary approach to manage and conserve a patient’s own blood, directing treatment options based on broad clinical assessment beyond haemoglobin alone, for which tissue perfusion and oxygenation could be useful. Our aim was to assess utility of non-invasive tissue-specific measures to compare PRBC transfusion with novel crystalloid treatments for haemorrhagic shock.MethodsA model of severe haemorrhagic shock was developed in an intensive care setting, with controlled haemorrhage in sheep according to pressure (mean arterial pressure 30–40 mmHg) and oxygen debt (lactate 4 mM) targets. We compared PRBC transfusion to fluid resuscitation with either PlasmaLyte or a novel crystalloid. Efficacy was assessed according to recovery of haemodynamic parameters and non-invasive measures of sublingual microcirculatory flow, regional tissue oxygen saturation, repayment of oxygen debt (arterial lactate), and a panel of inflammatory and organ function markers. Invasive measurements of tissue perfusion, oxygen tension and lactate levels were performed in brain, kidney, liver, and skeletal muscle. Outcomes were assessed during 4 h treatment and post-mortem, and analysed by one- and two-way ANOVA.ResultsEach treatment restored haemodynamic and tissue oxygen delivery parameters equivalently (p 0.05), despite haemodilution after crystalloid infusion to haemoglobin concentrations below 70 g/L (p 0.001). Recovery of vital organ-specific perfusion and oxygen tension commenced shortly before non-invasive measures improved. Lactate declined in all tissues and correlated with art

Published
2022

16. Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis

Author

Li Bassi, G., Gibbons, K., Suen, J. Y., Dalton, H. J., White, N., Corley, A., Shrapnel, S., Hinton, S., Forsyth, S., Laffey, J. G., Fan, E., Fanning, J. P., Panigada, M., Bartlett, R., Brodie, D., Burrell, A., Chiumello, D., Elhazmi, A., Esperatti, M., Grasselli, G., Hodgson, C., Ichiba, S., Luna, C., Marwali, E., Merson, L., Murthy, S., Nichol, A., Ogino, M., Pelosi, P., Torres, A., P. Y., Ng, Fraser, J. F., Al-Dabbous, T., Alfoudri, H., Shamsah, M., Elapavaluru, S., Berg, A., Horn, C., Mayasi, Y., Schroll, S., Meyer, D., Velazco, J., Ploskanych, L., Fikes, W., Bagewadi, R., Dao, M., White, H., Ehlers, A., Shalabi-McGuire, M., Witt, T., Grazioli, L., Lorini, L., Grandin, E. W., Nunez, J., Reyes, T., Obriain, D., Hunter, S., Ramanan, M., Affleck, J., Veerendra, H. H., Rai, S., Russell-Brown, J., Nourse, M., Joseph, M., Mitchell, B., Tenzer, M., Abe, R., Cho, H. J., Jeong, I. S., Rahman, N., Kakar, V., Brozzi, N., Mehkri, O., Krishnan, S., Duggal, A., Houltham, S., Graf, J., Diaz, R., Orrego, R., Delgado, C., Gonzalez, J., Sanchez, M. S., Piagnerelli, M., Sarrazin, J. V., Zabert, A. /P. G., Espinosa, L., Delgado, P., Delgado, V., Rincon, D. F. B., Yanten, A. M. M., Duque, M. B., Al-Hudaib, A., Callahan, M., Taufik, M. A., Wardoyo, E. Y., Gunawan, M., Trisnaningrum, N. S., Irawany, V., Rayhan, M., Pesenti, A., Zanella, A., Leone, M., Coppola, S., Colombo, S., Antonelli, M., Carelli, S., Grieco, D. L., Asaki, M., Hoshino, K., Salazar, L., Duarte, L., Laffey, J., Mcnicholas, B., Cosgrave, D., Mccaffrey, J., Bone, A., Hakeem, Y., Winearls, J., Tallott, M., Thomson, D., Arnold-Day, C., Cupido, J., Fanie, Z., Miller, M., Seymore, L., van Straaten, D., Hssain, A. A., Aliudin, J., Alqahtani, A. -R., Mohamed, K., Mohamed, A., Tan, D., Villanueva, J., Zaqout, A., Kurtzman, E., Ademi, A., Dobrita, A., El Aoudi, K., Segura, J., Giwangkancana, G., Ohshimo, S., Hitoshi, S., Osatnik, J., Joosten, A., Yang, M., Motos, A., Arancibia, F., Williams, V., Noel, A., Luque, N., Trung, T. H., Yacoub, S., Fantini, M., Garcia, R. N. J., Alvarez, E. C., Greti, A., Ceccato, A., Sanchez, A., Vazquez, A. L., Roche-Campo, F., Franch-Llasat, D., Tuazon, D., Amato, M., Cassimiro, L., Pola, F., Ribeiro, F., Fonseca, G., Dalton, H., Desai, M., Osborn, E., Deeb, H., Arcadipane, A., Martucci, G., Panarello, G., Vitiello, C., Bianco, C., Occhipinti, G., Rossetti, M., Cuffaro, R., Cho, S. -M., Shimizu, H., Moriyama, N., Kim, J. -B., Kitamura, N., Gebauer, J., Yokoyama, T., Al-Fares, A., Buabbas, S., Alamad, E., Alawadhi, F., Alawadi, K., Tanaka, H., Hashimoto, S., Yamazaki, M., T. -H., Oh, Epler, M., Forney, C., Kruse, L., Feister, J., Williamson, J., Grobengieser, K., Gnall, E., Golden, S., Caroline, M., Shapiro, T., Karaj, C., Thome, L., Sher, L., Vanderland, M., Welch, M., Mcdermott, S., Brain, M., Mineall, S., Kimura, D., Brazzi, L., Sales, G., Ogston, T., Nagpal, D., Fischer, K., Lorusso, R., Rangappa, R., Appu, A., Carton, E. G., Sen, A., Palacios, A., Rainey, D., Samoukoviv, G., Campisi, J., Durham, L., Neumann, E., Seefeldt, C., Falcucci, O., Emmrich, A., Guy, J., Johns, C., Potzner, K., Zimmermann, C., Espinal, A., Buchtele, N., Schwameis, M., Stecher, S. -S., Singh, D., Barnikel, M., Arenz, L., Zaaqoq, A., Galloway, L. A., Merley, C., Csete, M., Quesada, L., Saba, I., Kasugai, D., Hiraiwa, H., Tanaka, T., Purnama, Y., Dewayanti, S. R., Ardiyan, Juzar, D. A., Siagian, D., Chen, Y. -S., Ratsep, I., Oigus, G., Erikson, K., Post, A. -M., Enneveer, L., Sillaots, P., Manetta, F., Mihelis, E., Sarmiento, I. C., Narasimhan, M., Varrone, M., Komats, M., Garcia-Diaz, J., Harmon, C., Satyapriya, S. V., Bhatt, A., Mokadam, N. A., Uribe, A., Gonzalez, A., Shi, H., Mckeown, J., Pasek, J., Fiorda, J., Echeverria, M., Moreno, R., Zakhary, B., Cavana, M., Cucino, A., Foti, G., Giani, M., Russotto, V., Castagna, V., Dellamore, A., Navalesi, P., Shum, H. -P., Vuysteke, A., Usman, A., Acker, A., Smood, B., Mergler, B., Sertic, F., Subramanian, M., Sperry, A., Rizer, N., Burhan, E., Rasmin, M., Akmal, E., Sitompul, F., Lolong, N., Naivedh, B., Erickson, S., Barrett, P., Dean, D., Daugherty, J., Loforte, A., Khan, I., Abraar Quraishi, M., Desantis, O., So, D., Kandamby, D., Mandei, J. M., Natanael, H., Yudhalantang, E., Lantang, A., Wijaya, S. O., Jung, A., Ng, G., W. Y., Ng, Fang, S., Tabah, A., Ratcliffe, M., Duroux, M., Adachi, S., Nakao, S., Blanco, P., Prieto, A., Sanchez, J., Nicholson, M., Butt, W., Serratore, A., Delzoppo, C., Janin, P., Yarad, E., Totaro, R., Coles, J., Pujo, B., Balk, R., Vissing, A., Kapania, E., Hays, J., Fox, S., Yantosh, G., Mishin, P., Yuliarto, S., Hari Santoso, K., Djajalaksana, S., Fatoni, A. Z., Fukuda, M., Liu, K., Battaglini, D., Jimenez, J. F. M., Bastos, D., Gaiao, S., Rusmawatiningtyas, D., Buchner, J., Cho, Y. -J., Lee, S. H., Kawasaki, T., Munshi, L., Sakiyalak, P., Nitayavardhana, P., Seitz, T., Arora, R., Kent, D., Marino, D., Parwar, S., Cheng, A., Miller, J., Fujitani, S., Shimizu, N., Madhok, J., Owyang, C., Buscher, H., Reynolds, C., Maasikas, O., Beljantsev, A., Mihnovits, V., Akimoto, T., Aizawa, M., Horibe, K., Onodera, R., Young, M., George, T., Shekar, K., Mcguinness, N., Irvine, L., Flynn, B., Endo, T., Sugiyama, K., Shimizu, K., Exconde, K., Lussier, L., Lotz, G., Malfertheiner, M., Maier, L., Dreier, E., Kusumastuti, N. P., Mccloskey, C., Dabaliz, A. -A., Elshazly, T. B., Smith, J., Szuldrzynski, K. S., Bielanski, P., Wille, K., Parhar, K. K. S., Fiest, K. M., Codan, C., Shahid, A., Fayed, M., Evans, T., Garcia, R., Gutierrez, A., Song, T., Rose, R., Bennett, S., Richardson, D., Peek, G., Arora, L., Rappapport, K., Rudolph, K., Sibenaller, Z., Stout, L., Walter, A., Herr, D., Vedadi, N., Thompson, S., Sindt, L., Rajnic, S., Ewald, C., Hoffman, J., Ying, X., Kennedy, R., Griffee, M., Ciullo, A., Kida, Y., Roca, R. F., Riera, J. I., Contreras, S., Alegre, C., Kay, C., Fischer, I., Renner, E., Taniguci, H., Fraser, J., Bassi, G. L., Suen, J., Barnett, A., Pearse, I., Abbate, G., Hassan, H., Heinsar, S., Karnik, V. A., Ki, K., Oneill, H. F., Obonyo, N., Pimenta, L. P., Reid, J. D., Sato, K., Vuorinen, A., Wildi, K. S., Wood, E. S., Yerkovich, S., Lee, J., Plotkin, D., Citarella, B. W., Hartley, E., Lubis, B., Ikeyama, T., Bhaskar, B., Jung, J. -S., Mcguinness, S., Eastwood, G., Marta, S. R., Guarracino, F., Gerle, S., Coxon, E., Claro, B., Loverde, D., Patil, N., Parrini, V., Mcbride, A., Negaard, K., Ratsch, A., Abdelaziz, A., Uribe, J. D., Peris, A., Sanders, M., Emerson, D., Kamal, M., Povoa, P., Francis, R., Cherif, A., Joseph, S., Di Nardo, M., Heard, M., Kyle, K., Blackwell, R. A., Biston, P., Jeong, H. W., Smith, R., Prawira, Y., Montrucchio, G., Garcia, A. H., Salterain, N., Meyns, B., Moreno, M., Walia, R., Mehta, A., Schweda, A., Supriatna, M., Kirakli, C., Williams, M., Kim, K. H., Assad, A., Giraldo, E., Karolak, W., Balik, M., Pocock, E., Gajkowski, E., Masafumi, K., Barrett, N., Takeyama, Y., Park, S., Amin, F., Andriyani, F. M., Sudakevych, S., Vera, M., Cornejo, R., Schwarz, P., Mardini, A. C., de Paula, T., Neto, A. S., Villoldo, A., Colafranceschi, A. S., Iglesias, A. U., Granjean, J., Melro, L. M. G., Romualdo, G. F., Gaia, D., Souza, H., Galas, F., Mendiluce, R. M., Sosa, A., Martinez, I., Kurosawa, H., Salgado, J., Hugi-MayrCharbonneau, B. E., Barzilai, V. S., Monteiro, V., de Souza, R. R., Harper, M., Suzuki, H., Adams, C., Brieva, J., Nyale, G., Eltatar, F. S., Fatani, J., Baeissa, H., Masri, A. A., Rabie, A., Hui, M. Y., Yamane, M., Jung, H., Margaret, A. M., Nacpil, N., Ruck, K., Bakken, R., Jara, C., Felton, T., Berra, L., Shah, B., Chakraborty, A., Cardona, M., Capatos, G., Akkanti, B., Orija, A., Jain, H., Ito, A., Housni, B., Low, S., Iihara, K., Chavez, J., Ramanathan, K., Zabert, G., Naidoo, K., Seppelt, I., Vandyk, M., Macdonald, S., Mcgregor, R., Siebenaler, T., Flynn, H., Lofton, K., Aokage, T., Shigemitsu, K., Moscatelli, A., Fiorentino, G., Baumgaertel, M., Mba, S. E., Assy, J., Hutahaean, A., Roush, H., Sichting, K. A., Alessandri, F., Burns, D., Salt, G., Garabedian, C. P., Millar, J., Sim, M., Mattke, A., Mcauley, D., Tadili, J., Frenzel, T., Bar-Lavie, Y., Ortiz, A. B., Stone, J., Attokaran, A., Farquharson, M., Patel, B., Gunning, D., Baillie, K., Watson, P., Tamai, K., Sajinadiyasa, G. K., Kanyawati, D., Salgado, M., Sassine, A., Yudo, B., Mccaul, S., Lee, B., Lee, S. M., Afek, A., Iwashita, Y., Semedi, B. P., Metiva, J., Van Belle, N., Martin-Loeches, I., Ivatt, L., Woon, C. Y., Kang, H. M., Smith, T., James, E., Al-Rawas, N., Iwasaki, Y., King-Chung, K. C., Gudzenko, V., Hugi-Mayr, B., Taccone, F., Perdhana, F., Lamarche, Y., Ribeiro, J. M., Bradic, N., Van den Bossche, K., Lansink, O., Singh, G., Debeuckelaere, G., Stelfox, H. T., Yi, C., Elia, J., Tribble, T., Shankar, S., Padmanabhan, R., Hallinan, B., Paoletti, L., Leyva, Y., Fykuda, T., Badulak, J., Koch, J., Hackman, A., Janowaik, L., Hernandez, D., Osofsky, J., Donadello, K., Lawang, A., Fine, J., Davidson, B., Vazquez, A. O. R., COVID-19 Critical Care Consortium, and Consortium, COVID-19 Critical Care

Subjects
Male, Respiratory Distress Syndrome, COVID-19, Intensive care unit, Mechanical ventilation, Neuromuscular blocking agent, SARS-CoV-2, Aged, Female, Humans, Intensive Care Units, Middle Aged, Propensity Score, Respiration, Artificial, Neuromuscular Blocking Agents, Respiration, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Settore MED/41 - Anestesiologia, Critical Care and Intensive Care Medicine, COVID-19 Drug Treatment, Artificial, Human medicine
Abstract

Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods We analyzed a convenience sample of patients with COVID-19 and moderate-to-severe ARDS, admitted to 244 intensive care units within the COVID-19 Critical Care Consortium, from February 1, 2020, through October 31, 2021. Patients undergoing at least 2 days and up to 3 consecutive days of NMBAs (NMBA treatment), within 48 h from commencement of IMV were compared with subjects who did not receive NMBAs or only upon commencement of IMV (control). The primary objective in the PS-matched cohort was comparison between groups in 90-day in-hospital mortality, assessed through Cox proportional hazard modeling. Secondary objectives were comparisons in the numbers of ventilator-free days (VFD) between day 1 and day 28 and between day 1 and 90 through competing risk regression. Results Data from 1953 patients were included. After propensity score matching, 210 cases from each group were well matched. In the PS-matched cohort, mean (± SD) age was 60.3 ± 13.2 years and 296 (70.5%) were male and the most common comorbidities were hypertension (56.9%), obesity (41.1%), and diabetes (30.0%). The unadjusted hazard ratio (HR) for death at 90 days in the NMBA treatment vs control group was 1.12 (95% CI 0.79, 1.59, p = 0.534). After adjustment for smoking habit and critical therapeutic covariates, the HR was 1.07 (95% CI 0.72, 1.61, p = 0.729). At 28 days, VFD were 16 (IQR 0–25) and 25 (IQR 7–26) in the NMBA treatment and control groups, respectively (sub-hazard ratio 0.82, 95% CI 0.67, 1.00, p = 0.055). At 90 days, VFD were 77 (IQR 0–87) and 87 (IQR 0–88) (sub-hazard ratio 0.86 (95% CI 0.69, 1.07; p = 0.177). Conclusions In patients with COVID-19 and moderate-to-severe ARDS, short course of NMBA treatment, applied early, did not significantly improve 90-day mortality and VFD. In the absence of definitive data from clinical trials, NMBAs should be indicated cautiously in this setting.

Published
2022
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17. Post-Transplant Cardiac Contractility and Mitochondrial Function is Preserved Following 8 Hours Hypothermic Ex Vivo Perfusion in Sheep

Author

See Hoe, L., primary, Bouquet, M., additional, Hyslop, K., additional, Passmore, M., additional, Wells, M., additional, Sato, K., additional, Wilson, E., additional, Wildi, K., additional, Skeggs, K., additional, Palmeri, C., additional, Reid, J., additional, O'Neill, H., additional, Bartnikowski, N., additional, Jung, J., additional, Ainola, C., additional, Abbate, G., additional, Colombo, S., additional, Obonyo, N., additional, McDonald, C., additional, Shuker, T., additional, Heinsar, S., additional, Haymet, A., additional, Engkilde-Pedersen, S., additional, Peart, J., additional, Molenaar, P., additional, Li Bassi, G., additional, Suen, J., additional, McGiffin, D., additional, and Fraser, J., additional

Published
2022
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21. An Ovine Model of Hemorrhagic Shock and Resuscitation, to Assess Recovery of Tissue Oxygen Delivery and Oxygen Debt, and Inform Patient Blood Management.

Author

Dyer, WB, Tung, J-P, Li Bassi, G, Wildi, K, Jung, J-S, Colombo, SM, Rozencwajg, S, Simonova, G, Chiaretti, S, Temple, FT, Ainola, C, Shuker, T, Palmieri, C, Shander, A, Suen, JY, Irving, DO, Fraser, JF, Dyer, WB, Tung, J-P, Li Bassi, G, Wildi, K, Jung, J-S, Colombo, SM, Rozencwajg, S, Simonova, G, Chiaretti, S, Temple, FT, Ainola, C, Shuker, T, Palmieri, C, Shander, A, Suen, JY, Irving, DO, and Fraser, JF

Abstract

BACKGROUND: Aggressive fluid or blood component transfusion for severe hemorrhagic shock may restore macrocirculatory parameters, but not always improve microcirculatory perfusion and tissue oxygen delivery. We established an ovine model of hemorrhagic shock to systematically assess tissue oxygen delivery and repayment of oxygen debt; appropriate outcomes to guide Patient Blood Management. METHODS: Female Dorset-cross sheep were anesthetized, intubated, and subjected to comprehensive macrohemodynamic, regional tissue oxygen saturation (StO2), sublingual capillary imaging, and arterial lactate monitoring confirmed by invasive organ-specific microvascular perfusion, oxygen pressure, and lactate/pyruvate levels in brain, kidney, liver, and skeletal muscle. Shock was induced by stepwise withdrawal of venous blood until MAP was 30 mm Hg, mixed venous oxygen saturation (SvO2) < 60%, and arterial lactate >4 mM. Resuscitation with PlasmaLyte® was dosed to achieve MAP > 65 mm Hg. RESULTS: Hemorrhage impacted primary outcomes between baseline and development of shock: MAP 89 ± 5 to 31 ± 5 mm Hg (P < 0.01), SvO2 70 ± 7 to 23 ± 8% (P < 0.05), cerebral regional tissue StO2 77 ± 11 to 65 ± 9% (P < 0.01), peripheral muscle StO2 66 ± 8 to 16 ± 9% (P < 0.01), arterial lactate 1.5 ± 1.0 to 5.1 ± 0.8 mM (P < 0.01), and base excess 1.1 ± 2.2 to -3.6 ± 1.7 mM (P < 0.05). Invasive organ-specific monitoring confirmed reduced tissue oxygen delivery; oxygen tension decreased and lactate increased in all tissues, but moderately in brain. Blood volume replacement with PlasmaLyte® improved primary outcome measures toward baseline, confirmed by organ-specific measures, despite hemoglobin reduced from baseline 10.8 ± 1.2 to 5.9 ± 1.1 g/dL post-resuscitation (P < 0.01). CONCLUSION: Non-invasive measures of tissue oxygen delivery and oxygen debt repayment are suitable outcomes to inform Patient Blood Management of hemorrhagic shock, translatable for pre-clinical assessment of novel resuscitation s

Published
2021

22. Donor Heart Preservation by Hypothermic Ex Vivo Perfusion - Improved Recipient Survival and Successful Prolongation of Ischemic Time

Author

Hoe, L.E. See, primary, Wildi, K., additional, Skeggs, K., additional, Bouquet, M., additional, Sato, K., additional, Jung, J., additional, Ainola, C., additional, Hyslop, K., additional, Heinsar, S., additional, Abbate, G., additional, Colombo, S.M., additional, Passmore, M., additional, Wood, E.S., additional, Wells, M., additional, Bartnikowski, N., additional, O'Neill, H., additional, Reid, J., additional, Shuker, T., additional, Haymet, A., additional, Livingstone, S., additional, Sato, N., additional, Obonyo, N., additional, James, L., additional, He, T., additional, McDonald, C., additional, Mullins, D., additional, Engkilde-Pedersen, S., additional, Diab, S., additional, Millar, J.E., additional, Malfertheiner, M., additional, Marshall, L., additional, Nair, L., additional, Rozencwajg, S., additional, Wang, X., additional, Shek, Y., additional, Platts, D., additional, Chan, J., additional, Boon, C., additional, Black, D., additional, Helms, L., additional, Bradbury, L., additional, Haqqani, H., additional, Molenaar, P., additional, Bassi, G. Li, additional, Suen, J., additional, McGiffin, D.C., additional, and Fraser, J.F., additional

Published
2021
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23. Clinical risk scores and integrated clinical judgment in patients with suspected acute coronary syndrome

Author

Boeddinghaus, J, primary, Meier, M, additional, Nestelberger, T, additional, Lopez-Ayala, P, additional, Ratmann, P.D, additional, Wussler, D, additional, Wildi, K, additional, Rubini Gimenez, M, additional, Zimmermann, T, additional, Miro, O, additional, Martin-Sanchez, J, additional, Keller, D.I, additional, Gualandro, D.M, additional, Twerenbold, R, additional, and Mueller, C, additional

Published
2020
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24. Early diagnosis of myocardial infarction in patients presenting late after chest pain onset

Author

Boeddinghaus, J, primary, Nestelberger, T, additional, Lopez-Ayala, P, additional, Ratmann, P.D, additional, Wussler, D, additional, Zimmermann, T, additional, Wildi, K, additional, Rubini Gimenez, M, additional, Miro, O, additional, Martin-Sanchez, F.J, additional, Keller, D.I, additional, Kawecki, D, additional, Gualandro, D.M, additional, Twerenbold, R, additional, and Mueller, C, additional

Published
2020
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25. The Effects of Different Ventilatory Strategies on Pulmonary Mechanics and Gas Exchange During Heart Transplant: An Experimental Study

Author

Li Bassi, G., primary, Colombo, S., additional, Heinsar, S., additional, Wildi, K., additional, Ainola, C., additional, Jung, J.-S., additional, Abbate, G., additional, See Hoe, L., additional, Sato, K., additional, Wang, X., additional, Skeggs, K., additional, Livingstone, S., additional, Boquet, M., additional, Passmore, M., additional, Sato, N., additional, Reid, J., additional, James, L., additional, Wilson, E., additional, McGiffin, D., additional, Suen, J., additional, and Fraser, J., additional

Published
2020
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26. Corticosteroids in Hypoinflammatory and Hyperinflammatory Acute Respiratory Distress Syndrome Subphenotypes: An Experimental Study

Author

Wildi, K., primary, Li Bassi, G., additional, Ainola, C., additional, Livingstone, S., additional, Colombo, S., additional, Sato, K., additional, Wang, X., additional, Heinsar, S., additional, Abbate, G., additional, Bouquet, M., additional, Passmore, M., additional, Reid, J., additional, O`Neill, H., additional, Wood, E., additional, Ki, K., additional, Jung, J.S., additional, Suen, J., additional, and Fraser, J., additional

Published
2020
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27. Pulmonary Derangement in Two Novel Ovine Model of Acute Respiratory Distress Syndrome Subphenotypes

Author

Wildi, K., primary, Li Bassi, G., additional, Ainola, C., additional, Livingstone, S., additional, Colombo, S.M., additional, Sato, K., additional, Wang, X., additional, Heinsar, S., additional, Abbate, G., additional, Bouquet, M., additional, Passmore, M., additional, Reid, J., additional, O`Neill, H., additional, Wood, E., additional, Ki, K., additional, Jung, J.S., additional, Fraser, J., additional, and Suen, J., additional

Published
2020
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28. Metabolic and Mitochondrial Alterations Following Brain Death and Heart Transplantation

Author

Hoe, L.E. See, primary, Wells, M.A., additional, Bouquet, M., additional, Hyslop, K., additional, Passmore, M.R., additional, Bartnikowski, N., additional, Obonyo, N.G., additional, Reid, J., additional, O'Neill, H., additional, Shuker, T., additional, McDonald, C., additional, Engkilde-Pedersen, S., additional, Wildi, K., additional, Ainola, C., additional, Skeggs, K., additional, Jung, J., additional, Colombo, S., additional, Sato, K., additional, James, L., additional, He, P., additional, Wood, E.S., additional, Heinser, S., additional, Wang, X., additional, Abbate, G., additional, Livingstone, S., additional, Haymet, A., additional, Walweel, K., additional, Mullins, D., additional, Marasco, S., additional, Diab, S., additional, Tung, J., additional, Molenaar, P., additional, Bassi, G. Li, additional, Suen, J.Y., additional, McGiffin, D.C., additional, and Fraser, J.F., additional

Published
2020
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29. Metabolic and mitochondrial alterations following brain death and heart transplantation

Author

Hoe, L. E.See, Wells, M. A., Bouquet, M., Hyslop, K., Passmore, M. R., Bartnikowski, N., Obonyo, N. G., Reid, J., O'Neill, H., Shuker, T., McDonald, C., Engkilde-Pedersen, S., Wildi, K., Ainola, C., Skeggs, K., Jung, J., Colombo, S., Sato, K., James, L., He, P., Wood, E. S., Heinser, S., Wang, X., Abbate, G., Livingstone, S., Haymet, A., Walweel, K., Mullins, D., Marasco, S., Diab, S., Tung, J., Molenaar, P., Bassi, G. Li, Suen, J. Y., McGiffin, D. C., Fraser, J. F., Hoe, L. E.See, Wells, M. A., Bouquet, M., Hyslop, K., Passmore, M. R., Bartnikowski, N., Obonyo, N. G., Reid, J., O'Neill, H., Shuker, T., McDonald, C., Engkilde-Pedersen, S., Wildi, K., Ainola, C., Skeggs, K., Jung, J., Colombo, S., Sato, K., James, L., He, P., Wood, E. S., Heinser, S., Wang, X., Abbate, G., Livingstone, S., Haymet, A., Walweel, K., Mullins, D., Marasco, S., Diab, S., Tung, J., Molenaar, P., Bassi, G. Li, Suen, J. Y., McGiffin, D. C., and Fraser, J. F.

Abstract

PURPOSE: Brain death (BD) causes metabolic and energetic imbalances leading to cardiac dysfunction, and predisposes the donor heart to further injury following heart transplantation (HTx). The metabolic mechanisms required for myocardial energy production during BD and subsequent HTx are poorly understood. Our aim was to determine the myocardial metabolic profile and mitochondrial function following donor BD and HTx. METHODS: Donor BD in sheep was induced by inflation of a catheter placed through the skull (catheter placement, but no inflation for SHAM), followed by 24 hrs monitoring, and heart procurement (n=6/group, BD vs. SHAM). Additional donor hearts exposed to BD/SHAM were flushed with cold St Thomas cardioplegia, and stored via cold static storage (CSS) for ∼2 hrs. Following standard orthotopic HTx, recipients were weaned off bypass and monitored for ≤6 hrs prior to heart procurement (n=4/group, BD-Tx vs. Sh-Tx). Cardiac mitochondrial function was assessed using high resolution respirometry. Metabolic profiles were determined in hearts using metabolomics. Cardiac mitochondrial function was also determined in two sheep that underwent HTx following BD and 8 hr hypothermic ex vivo perfusion (HEVP) preservation. RESULTS: BD caused significant right ventricular (RV) mitochondrial uncoupling (vs. SHAM). HTx following CSS also impaired RV mitochondrial function, with these effects more pronounced in hearts exposed to both donor BD and HTx. Early findings show that HEVP improved cardiac mitochondrial function post-HTx (vs. CSS). Metabolically, BD increased myocardial amino-acid utilisation and accumulation of glucose metabolites. Post-HTx, particularly in those exposed to donor BD, there was a significant decrease in metabolites involved in mitochondrial respiration (eg. NAD, Acetyl-CoA) and accumulation of fatty acids and xanthine (purine breakdown). CONCLUSION: BD appears to trigger cardiac mitochon

Published
2020

30. 120 Hypothermic Ex Vivo Perfusion of Brain Dead Donor Hearts Improves Survival, Systemic Inflammation and Cardiac Function Following Heart Transplantation

Author

See Hoe, L., primary, McGiffin, D., additional, Wildi, K., additional, Obonyo, N., additional, Bouquet, M., additional, Wells, M., additional, Skeggs, K., additional, McDonald, C., additional, Engkilde-Pedersen, S., additional, Bartnikowski, N., additional, Colombo, S., additional, Ainola, C., additional, Passmore, M., additional, Hyslop, K., additional, Wood, E., additional, Shuker, T., additional, Sato, K., additional, Jung, J., additional, Heinser, S., additional, James, L., additional, Reid, J., additional, O'Neill, H., additional, Livingstone, S., additional, Abbate, G., additional, He, P., additional, Sato, N., additional, Boon, C., additional, Black, D., additional, Haymet, A., additional, Mullins, D., additional, Marasco, S., additional, Chan, W., additional, Chan, J., additional, Platts, D., additional, Diab, S., additional, Millar, J., additional, Li Bassi, G., additional, Suen, J., additional, and Fraser, J., additional

Published
2020
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31. 121 Hypothermic Ex Vivo Perfusion Preserves Post-Transplant Donor Cardiac Function

Author

Sato, K., primary, See Hoe, L., additional, Obonyo, N., additional, Wildi, K., additional, Colombo, S., additional, Bouquet, M., additional, Passmore, M., additional, Bartnikowski, N., additional, Wells, M., additional, Skeggs, K., additional, McDonald, C., additional, Hyslop, K., additional, Wood, E., additional, Heinser, S., additional, Ainola, C., additional, Jung, J., additional, James, L., additional, Abbate, G., additional, Haymet, A., additional, Engkilde-Pedersen, S., additional, Reid, J., additional, O'Neill, H., additional, Shuker, T., additional, He, P., additional, Sato, N., additional, Diab, S., additional, Mullins, D., additional, Livingstone, S., additional, Wang, X., additional, Rozencwajg, S., additional, Malfertheiner, M., additional, Platts, D., additional, Chan, J., additional, Li Bassi, G., additional, Suen, J., additional, McGiffin, D., additional, and Fraser, J., additional

Published
2020
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32. 111 Epicardial Echocardiography in a Novel Ovine Model of Cardiopulmonary Failure

Author

Sato, K., primary, Heinsar, S., additional, Rozencwajg, S., additional, Colombo, S., additional, Wildi, K., additional, Jung, J., additional, Ainola, C., additional, Wang, X., additional, Abbate, G., additional, Sato, N., additional, Reid, J., additional, Bouquet, M., additional, Lo Cocco, V., additional, Wood, E., additional, Suen, J., additional, Combes, A., additional, Lorusso, R., additional, Pesenti, A., additional, Li Bassi, G., additional, Chan, J., additional, and Fraser, J., additional

Published
2020
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33. P1765Hyperacute T-wave in the early diagnosis of acute myocardial infarction

Author

Koechlin, L, primary, Strebel, I, additional, Boeddinghaus, J, additional, Nestelberger, T, additional, Wussler, D, additional, Walter, J, additional, Zimmermann, T, additional, Badertscher, P, additional, Wildi, K, additional, Puelacher, C, additional, Du Fay De Lavallaz, J, additional, Rubini Gimenez, M, additional, Reichlin, T, additional, Twerenbold, R, additional, and Mueller, C, additional

Published
2019
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35. 3305Validation of a novel high-sensitivity cardiac troponin i assay for early diagnosis of acute myocardial infarction

Author

Boeddinghaus, J, primary, Twerenbold, R, additional, Nestelberger, T, additional, Koechlin, L, additional, Wussler, D, additional, Wildi, K, additional, Puelacher, C, additional, Du Fay De Lavallaz, J, additional, Rubini Gimenez, M, additional, Walter, J E, additional, Zimmermann, T, additional, Miro, O, additional, Martin-Sanchez, F J, additional, Keller, D I, additional, and Mueller, C, additional

Published
2019
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36. P1695Incidence and outcomes of unstable angina compared to non-ST elevation myocardial infarction

Author

Puelacher, C, primary, Gugala, M, additional, Adamson, P D, additional, Shah, A S V, additional, Chapmann, A R, additional, Anand, A, additional, Boeddinghaus, J, additional, Nestelberger, T, additional, Twerenbold, R, additional, Wildi, K, additional, Rubini Gimenez, M, additional, Osswald, S, additional, Mills, N L, additional, and Mueller, C, additional

Published
2019
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37. Characterisation of Cardiac Neurohormonal and Inflammatory Changes Induced by Brain Death in a Novel Ovine Heart Transplant Model

Author

Hoe, L. See, primary, Shuker, T., additional, Bartnikowski, N., additional, Passmore, M., additional, Bouquet, M., additional, Obonyo, N., additional, Engkilde-Pedersen, S., additional, McDonald, C., additional, Wells, M., additional, Boon, A., additional, Hyslop, K., additional, James, L., additional, Wildi, K., additional, Cullen, L., additional, Bassi, G. Li, additional, Suen, J., additional, McGiffin, D., additional, and Fraser, J., additional

Published
2019
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39. 1086Derivation and validation of a 0/1h-algorithm to diagnose myocardial infarction using cardiac myosin-binding protein c - direct comparison to hs-cTnI

Author

Kaier, T E, primary, Twerenbold, R, additional, Alaour, B, additional, Badertscher, P, additional, Puelacher, C, additional, Marjot, J, additional, Boeddinghaus, J, additional, Nestelberger, T, additional, Wildi, K, additional, Wussler, D, additional, Rubini-Gimenez, M, additional, Reichlin, T, additional, Marber, M, additional, and Mueller, C, additional

Published
2018
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40. P4612Validation of a score for early discrimination of patients with type 2 myocardial infarction

Author

Nestelberger, T, primary, Boeddinghaus, J, additional, Twerenbold, R, additional, Badertscher, P, additional, Wildi, K, additional, Wussler, D, additional, Rubini Gimenez, M, additional, Puelacher, C, additional, Du Fay De Lavallaz, J, additional, Kozhuharov, N, additional, Morawiec, B, additional, Miro, O, additional, Muzyk, P, additional, Reichlin, T, additional, and Mueller, C, additional

Published
2018
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41. P5429Use and effect of statins in non-cardiac surgery

Author

Puelacher, C, primary, Lurati Buse, G, additional, Rinderknecht, T, additional, Du Fay De Lavallaz, J, additional, Hidvegi, R, additional, Wildi, K, additional, Sazgary, L, additional, Lampart, A, additional, Gualandro, D M, additional, Osswald, S, additional, Caramelli, B, additional, and Mueller, C, additional

Published
2018
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43. Factors associated with positive blood cultures in outpatients with suspected bacteremia

Author

Wildi, K., Tschudin-Sutter, S., Dell-Kuster, S., Frei, R., Bucher, H., Nüesch, R., Wildi, K., Tschudin-Sutter, S., Dell-Kuster, S., Frei, R., Bucher, H., and Nüesch, R.

Abstract

Blood cultures are routinely taken in outpatients with fever and suspected bacterial infections. However, in the majority of cases, they are not informative and of limited value for clinical decision making. The aim of this study was therefore to investigate factors associated with positive blood cultures in outpatients presenting to an outpatient clinic and emergency room. This was a case-control study of all outpatients with positive blood cultures from January 1, 2006 to October 31, 2007 and matched control patients with negative blood cultures in the same time period. Microbiology results and medical charts were reviewed to determine factors associated with positive blood cultures. The presence of a systemic inflammation response syndrome (SIRS) (OR 2.7, 95% Cl 1.0-7.2) and increased C-reactive protein (CRP) (OR 1.1 per 10mg/l, 95% Cl 1.0-1.2) were the most powerful predictive values for the development of positive blood cultures. In positive cases serum albumin was lower (35mg/l versus 39mg/l) than in controls. SIRS, increasing CRP and low albumin were associated with positive blood cultures in outpatients. With simple clinical assessment and few laboratory tests indicative of infection, it is possible to define a group at higher risk for bacteremia in outpatients

Published
2018

44. Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection A Collaborative Meta-analysis

Author

Pickering J, Than M, Cullen L, Aldous S, ter Avest E, Body R, Carlton E, Collinson P, Dupuy A, Ekelund U, Eggers K, Florkowski C, Freund Y, George P, Goodacre S, Greenslade J, Jaffe A, Lord S, Mokhtari A, Mueller C, Munro A, Mustapha S, Parsonage W, Peacock W, Pemberton C, Richards A, Sanchis J, Staub L, Troughton R, Twerenbold R, Wildi K, and Young J

Published
2017

46. 53Combined cardiac troponin T and I measurements quadruple the number of safe rule-outs for acute myocardial infarction with a single blood draw at presentation

Author

Van Der Linden, N., primary, Wildi, K., additional, Twerenbold, R., additional, Nestelberger, T., additional, Boeddinghaus, J., additional, Puelacher, C., additional, Badertscher, P., additional, Rubini Gimenez, M., additional, Bekers, O., additional, Osswald, S., additional, Van Dieijen-Visser, M.P., additional, Mingels, A.M., additional, Reichlin, T., additional, Meex, S.J.R., additional, and Mueller, C., additional

Published
2017
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48. Validation of NICE diagnostic guidance for rule out of myocardial infarction using high-sensitivity troponin tests

Author

Parsonage, W A, primary, Mueller, C, additional, Greenslade, J H, additional, Wildi, K, additional, Pickering, J, additional, Than, M, additional, Aldous, S, additional, Boeddinghaus, J, additional, Hammett, C J, additional, Hawkins, T, additional, Nestelberger, T, additional, Reichlin, T, additional, Reidt, S, additional, Rubin Gimenez, M, additional, Tate, J R, additional, Twerenbold, R, additional, Ungerer, J P, additional, and Cullen, L, additional

Published
2016
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49. Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients

Author

Meller, B., Cullen, L., Parsonage, W., Greenslade, J., Aldous, S., Reichlin, T., Wildi, K., Twerenbold, R., Jaeger, C., Hillinger, P., Haaf, P., Puelacher, C., Kern, V., Rentsch, K., Stallone, F., Gimenez, M., Ballarino, P., Bassetti, S., Walukiewicz, A., Troughton, R., Pemberton, C., Richards, M., Chu, Chuan-Wei, Reid, Christopher, Than, M., Mueller, C., Meller, B., Cullen, L., Parsonage, W., Greenslade, J., Aldous, S., Reichlin, T., Wildi, K., Twerenbold, R., Jaeger, C., Hillinger, P., Haaf, P., Puelacher, C., Kern, V., Rentsch, K., Stallone, F., Gimenez, M., Ballarino, P., Bassetti, S., Walukiewicz, A., Troughton, R., Pemberton, C., Richards, M., Chu, Chuan-Wei, Reid, Christopher, Than, M., and Mueller, C.

Abstract

Background: We aimed to evaluate the efficacy and safety of using high-sensitivity cardiac troponin T (hs-cTnT) within an accelerated diagnostic protocol (ADP) in patients presenting with symptoms suggestive of acute myocardial infarction (AMI) for rapid rule-out of AMI. Methods: In two independent large multicenter studies, levels of hs-cTnT at presentation and at 2 h were combined with the Thrombolysis In Myocardial Infarction (TIMI) risk score and ECG findings. The ADP defined patients with normal levels of hs-cTnT at presentation and 2 h, a TIMI score ≤ 1, and normal ECG findings as candidates for rapid rule-out of AMI and rapid discharge. Major adverse cardiac events (MACEs) occurring within 30-days were centrally adjudicated by two independent cardiologists. Results: In the derivation cohort, among 1085 consecutive patients 198 patients (18.2%) had a MACE. The ADP classified 374 patients (34.5%) as low-risk. None of these patients had a MACE at 30 days, resulting in a negative predictive value (NPV) of 100% (95% CI, 99.0–100%) and a sensitivity of 100% (95% CI, 98.2%–100%). In the validation cohort, among 1590 consecutive patients 231 patients (14.5%) had a MACE. The ADP classified 641 patients (40.3%) as low-risk. 6 of these patients had a MACE at 30 days, resulting in a NPV of 99.1% (95% CI, 98.0–99.6%) and a sensitivity of 97.4% (95% CI, 94.5–98.8%). Conclusions: The ADP including hs-cTnT allows early identification 35 to 40% of patients to be at extremely low risk of MACE and therefore ideal candidates for outpatient management.

Published
2015

50. BNP but Not s-cTnln is associated with cardioembolic aetiology and predicts short and long term prognosis after cerebrovascular events

Author

Nigro, N, Wildi, K, Mueller, C, Schuetz, P, Mueller, B, Fluri, F, Christ-Crain, M, Katan, M, Nigro, N, Wildi, K, Mueller, C, Schuetz, P, Mueller, B, Fluri, F, Christ-Crain, M, and Katan, M

Abstract

BACKGROUND: We analyzed the prognostic value of b-type natriuretic peptide (BNP) and sensitive cardiac Troponin (s-cTnI) in patients with ischemic stroke or transient ischemic attack (TIA) and their significance in predicting stroke aetiology. METHODS: In a prospectively enrolled cohort we measured BNP and s-cTnI levels upon admission. Primary endpoints were mortality, unfavorable functional outcome and stroke recurrence after 90 days and after 12 months. Secondary endpoint was cardioembolic aetiology. RESULTS: In 441 patients BNP but not s-cTnI remained an independent predictor for death with an adjusted HR of 1.2 (95% CI 1.1-1.4) after 90 days and 1.2 (95% CI 1.0-1.3) after one year. The comparison of the Area under Receiver Operating Characteristic (AUROC) of model A (age, NIHSS) and model B (age, NIHSS, BNP) showed an improvement in the prediction of mortality (0.85 (95% CI 0.79-0.90) vs. 0.86 (95% CI 0.81-0.92), Log Rank p = 0.004). Furthermore the category free net reclassification improvement (cfNRI) when adding BNP to the multivariate model was 57.5%, p<0.0001. For the prediction of functional outcome or stroke recurrence both markers provided no incremental value. Adding BNP to a model including age, atrial fibrillation and heart failure lead to a higher discriminatory accuracy for identification of cardioembolic stroke than the model without BNP (AUC 0.75 (95% CI 0.70-0.80) vs. AUC 0.79, (95% CI 0.75-0.84), p = 0.008). CONCLUSION: BNP is an independent prognostic maker for overall mortality in patients with ischemic stroke or TIA and may improve the diagnostic accuracy to identify cardioembolic aetiology. TRIAL REGISTRATION: ClinicalTrials.gov NCT00390962.

Published
2014

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