312 results on '"Willekens, Christophe"'
Search Results
2. CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia
- Author
-
Deschamps, Paul, Wacheux, Margaux, Gosseye, Axel, Morabito, Margot, Pages, Arnaud, Lyne, Anne-Marie, Alfaro, Alexia, Rameau, Philippe, Imanci, Aygun, Chelbi, Rabie, Marchand, Valentine, Renneville, Aline, Patnaik, Mrinal M., Lapierre, Valerie, Badaoui, Bouchra, Wagner-Ballon, Orianne, Berthon, Celine, Braun, Thorsten, Willekens, Christophe, Itzykson, Raphael, Fenaux, Pierre, Thepot, Sylvain, Etienne, Gabriel, Elvira-Matelo, Emilie, Porteu, Francoise, Droin, Nathalie, Perie, Leila, Laplane, Lucie, Solary, Eric, and Selimoglu-Buet, Dorothee more...
- Subjects
Cytokines -- Physiological aspects -- Health aspects ,Hematopoiesis -- Analysis -- Health aspects ,Chronic myelomonocytic leukemia -- Risk factors -- Development and progression -- Prognosis ,Granulocytes -- Physiological aspects -- Health aspects ,Health care industry - Abstract
Chronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy with limited therapeutic options. Single-cell analysis of clonal architecture demonstrates early clonal dominance with few residual WT hematopoietic stem cells. Circulating myeloid cells of the leukemic clone and the cytokines they produce generate a deleterious inflammatory climate. Our hypothesis is that therapeutic control of the inflammatory component in CMML could contribute to stepping down disease progression. The present study explored the contribution of immature granulocytes (iGRANs) to CMML progression. iGRANs were detected and quantified in the peripheral blood of patients by spectral and conventional flow cytometry. Their accumulation was a potent and independent poor prognostic factor. These cells belong to the leukemic clone and behaved as myeloid-derived suppressor cells. Bulk and single-cell RNA-Seq revealed a proinflammatory status of iGRAN that secreted multiple cytokines of which CXCL8 was at the highest level. This cytokine inhibited the proliferation of WT but not CMML hematopoietic stem and progenitor cells (HSPCs) in which CXCL8 receptors were downregulated. CXCL8 receptor inhibitors and CXCL8 blockade restored WT HSPC proliferation, suggesting that relieving CXCL8 selective pressure on WT HSPCs is a potential strategy to slow CMML progression and restore some healthy hematopoiesis., Introduction Chronic myelomonocytic leukemia (CMML) is a myeloid malignancy defined by overlapping features of both myeloproliferative and myelodysplastic neoplasms (1). CMML diagnosis is based on sustained absolute and relative peripheral [...] more...
- Published
- 2024
- Full Text
- View/download PDF
Catalog
3. Correction: Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers
- Author
-
Danlos, François-Xavier, Grajeda-Iglesias, Claudia, Durand, Sylvère, Sauvat, Allan, Roumier, Mathilde, Cantin, Delphine, Colomba, Emeline, Rohmer, Julien, Pommeret, Fanny, Baciarello, Giulia, Willekens, Christophe, Vasse, Marc, Griscelli, Frank, Fahrner, Jean-Eudes, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Nirmalathasan, Nitharsshini, Bredel, Delphine, Mouraud, Séverine, Pradon, Caroline, Stoclin, Annabelle, Rozenberg, Flore, Duchemin, Jérôme, Jourdi, Georges, Ellouze, Syrine, Levavasseur, Françoise, Albigès, Laurence, Soria, Jean-Charles, Barlesi, Fabrice, Solary, Eric, André, Fabrice, Pène, Frédéric, Ackerman, Félix, Mouthon, Luc, Zitvogel, Laurence, Marabelle, Aurélien, Michot, Jean-Marie, Fontenay, Michaela, and Kroemer, Guido more...
- Published
- 2024
- Full Text
- View/download PDF
4. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials
- Author
-
Hermine, Olivier, Mariette, Xavier, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Resche-Rigon, Matthieu, Tharaux, Pierre-Louis, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Porcher, Raphaël, Pourchet-Martinez, Valerie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Raked, Nabil, Mameri, Lakhdar, Montlahuc, Claire, Biard, Lucie, Alary, St.phanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Charreteur, Robin, Dupre, Céline, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Pavy, Stephan, Nocturne, Gaétane, Bitoun, Samuel, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stephane, Baudry, Elodie, Verny, Christiane, Lefevre, Edouard, Zaidan, Mohamad, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Grimaldi, Lamiae, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Soléne, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Le Tiec, Clotilde, Verstuyft, Céline, Roques, Anne-Marie, Georgin-Lavialle, Sophie, Senet, Patricia, Pialoux, Gilles, Soria, Angele, Parrot, Antoine, François, Helene, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadege, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefévre, Guillaume, Gottenberg, Jacques-Eric, Hansmann, Yves, Blanc, Frédéric, Ohlmann-Caillard, Sophie, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurelien, Heger, Bob, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Mertes, Paul-Michel, Noll, Eric, Oberlin, Mathieu, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Weill, François, Meyer, Nicolas, Andres, Emmanuel, Demonsant, Eric, Tayebi, Hakim, Nisand, Gabriel, Brin, Stéphane, Sublon, Cédric, Becker, Guillaume, Hutt, Anne, Martin, Tristan, Bayer, Sophie, Metzger, Catherine, Mekinian, Arsene, Abisror, Noémie, Adedjouma, Amir, Bollens, Diane, Bonneton, Marion, Bourcicaux, Nathalie, Bourrier, Anne, Thibault Chiarabiani, Maria Chauchard, Chopin, Doroth.e, Cohen, Jonathan, Devred, Ines, Donadille, Bruno, Fain, Olivier, Hariri, Geoffrey, Jachiet, Vincent, Ingliz, Patrick, Garnier, Marc, Gatfosse, Marc, Ghrenassia, Etienne, Gobert, Delphine, Krause le Garrec, Jessica, Landman, Cecilia, Lavillegrand, Jean Remy, Lefebvre, Benedicte, Mahevas, Thibault, Mazerand, Sandie, Meynard, Jean Luc, Morgand, Marjolaine, Ouaz.ne, Zineb, Pacanowski, Jerome, Riviere, S.bastien, Seksik, Philippe, Sokol, Harry, Soliman, Heithem, Valin, Nadia, Urbina, Thomas, McAvoy, Chloé, Miranda, Maria Pereira, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Nguyen, Anne Daguenel, Girault, Elise, Mayala-Kanda, Cl.mentine, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean-Sébastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Pennet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Denis, Jesuthasan, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Val.rie, Tréhan, Anne, Vigna, Véronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charléne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, Xavier, Ghosn, Jade, Bachelard, Antoine, Rachline, Anne, Isernia, Valentina, Bao-chau, Phung, Vallois, Dorothée, Sautereau, Aurelie, Neukrich, Catherine, Dossier, Antoine, Borie, Raphaël, Crestani, Bruno, Ducrocq, Gregory, Steg, Philippe Gabriel, Dieude, Philippe, Papo, Thomas, Marcault, Estelle, Chaudhry, Marhaba, Da Silveira, Charléne, Metois, Annabelle, Mahenni, Ismahan, Meziani, Meriam, Nilusmas, Cyndie, Le Gac, Sylvie, Ndiaye, Awa, Louni, Fran.oise, Chansombat, Malikhone, Julia, Zelie, Chalal, Solaya, Chalal, Lynda, Kramer, Laura, Le Grand, Jeniffer, Ouifiya, Kafif, Piquard, Valentine, Tubiana, Sarah, Nguyen, Yann, Honsel, Vasco, Weiss, Emmanuel, Codorniu, Anais, Zarrouk, Virginie, de Lastours, Victoire, Uzzan, Matthieu, Gamany, Naura, Claveirole, Agathe, Navid, Alexandre, Fouque, Tiffanie, Cohen, Yonathan, Lupo, Maya, Gilles, Constance, Rahli, Roza, Louis, Zeina, Boutboul, David, Galicier, Lionel, Amara, Yaël, Archer, Gabrielle, Benattia, Amira, Bergeron, Anne, Bondeelle, Louise, de Castro, Nathalie, Clément, Melissa, Darmon, Michaël, Denis, Blandine, Dupin, Clairelyne, Feredj, Elsa, Feyeux, Delphine, Joseph, Adrien, Lenglin, Etienne, Le Guen, Pierre, Liégeon, Geoffroy, Lorillon, Gwenaël, Mabrouki, Asma, Mariotte, Eric, Martin de Frémont, Grégoire, Mirouse, Adrien, Molina, Jean-Michel, Peffault de Latour, Régis, Oksenhendler, Eric, Saussereau, Julien, Tazi, Abdellatif, Tudesq, Jean-Jacques, Zafrani, Lara, Brindele, Isabelle, Bugnet, Emmanuelle, Lebras, Karine Celli, Chabert, Julien, Djaghout, Lamia, Fauvaux, Catherine, Jegu, Anne Lise, Kozakiewicz, Ewa, Meunier, Martine, Tremorin, Marie-Thérèse, Davoine, Claire, Madelaine, Isabelle, Caillat-Zucman, Sophie, Delaugerre, Constance, Morin, Florence, Sène, Damien, Burlacu, Ruxandra, Chousterman, Benjamin, Mégarbanne, Bruno, Richette, Pascal, Riveline, Jean-Pierre, Frazier, Aline, Vicaut, Eric, Berton, Laure, Hadjam, Tassadit, Vazquez-Ibarra, Miguel Alejandro, Jourdaine, Clément, Tran, Olivia, Jouis, Véronique, Jacob, Aude, Smati, Julie, Renaud, Stéphane, Pernin, Claire, Suarez, Lydia, Semerano, Luca, Abad, Sébastien, nainous, Ruben B., Bonnet, Nicolas, Comparon, Celine, Cohen, Yves, Cordel, Hugues, Dhote, Robin, Dournon, Nathalie, Duchemann, Boris, Ebstein, Nathan, Gille, Thomas, Giroux-Leprieur, Benedicte, Goupil de Bouille, Jeanne, Nunes, Hilario, Oziel, Johanna, Roulot, Dominique, Sese, Lucile, ClaireTantet, Uzunhan, Yurdagul, Bloch-Queyrat, Coralie, Levy, Vincent, Messani, Fadhila, Rahaoui, Mohammed, Petit, Myléne, Brahmi, Sabrina, Rathoin, Vanessa, Rigal, Marthe, Costedoat-Chalumeau, Nathalie, Luong, Liem Binh, Hamou, Zakaria Ait, Benghanem, Sarah, Blanche, Philippe, Carlier, Nicolas, Chaigne, Benjamin, Gauzit, Remy, Joumaa, Hassan, Jozwiak, Mathieu, Lachétre, Marie, Lafoeste, Hélène, Launay, Odie, Legendre, Paul, Marey, Jonathan, Morbieu, Caroline, Palmieri, Lola-Jade, Szwebel, Tali-Anne, Abdoul, Hendy, Bruneau, Alexandra, Beclin-Clabaux, Audrey, Larrieu, Charly, Montanari, Pierre, Dufour, Eric, Clarke, Ada, Le Bourlout, Catherine, Marin, Nathalie, Menage, Nathalie, Saleh-Mghir, Samira, Cisse, Mamadou Salif, Cheref, Kahina, Guerin, Corinne, Zerbit, Jérémie, Michel, Marc, Gallien, Sébastien, Crickx, Etienne, Le Vavasseur, Benjamin, Kempf, Emmanuelle, Jaffal, Karim, Vindrios, William, Oniszczuk, Julie, Guillaud, Constance, Lim, Pascal, Fois, Elena, Melica, Giovanna, Matignon, Marie, Jalabert, Maud, Lelièvre, Jean-Daniel, Schmitz, David, Bourhis, Marion, Belazouz, Sylia, Languille, Laetitia, Boucle, Caroline, Cita, Nelly, Didier, Agnés, Froura, Fahem, Ledudal, Katia, Sadaoui, Thiziri, Thiemele, Alaki, Le Febvre De Bailly, Delphine, Verlinde, Muriel Carvhalo, Mayaux, Julien, Cacoub, Patrice, Saadoun, David, Vautier, Mathieu, Bugaut, Héléne, Benveniste, Olivier, Allenbach, Yves, Leroux, Gaëlle, Rigolet, Aude, Guillaume-Jugnot, Perrine, Domont, Fanny, Desbois, Anne Claire, Comarmond, Chloé, Champtiaux, Nicolas, Toquet, Segolene, Ghembaza, Amine, Vieira, Matheus, Maalouf, Georgina, Boleto, Goncalo, Ferfar, Yasmina, Corvol, Jean-Christophe, Louapre, C.line, Sambin, Sara, Mariani, Louise-Laure, Karachi, Carine, Tubach, Florence, Estellat, Candice, Gimeno, Linda, Martin, Karine, Bah, Aicha, Keo, Vixra, Ouamri, Sabrine, Messaoudi, Yasmine, Yelles, Nessima, Faye, Pierre, Cavelot, Sebastien, Larcheveque, Cecile, Annonay, Laurence, Benhida, Jaouad, Zahrate-Ghoul, Aida, Hammal, Soumeya, Belilita, Ridha, Charbonnier, Fanny, Aguilar, Claire, Alby-Laurent, Fanny, Burger, Carole, Campos-Vega, Clara, Chavarot, Nathalie, Fournier, Benjamin, Rouzaud, Claire, Vimpére, Damien, Elie, Caroline, Bakouboula, Prissile, Choupeaux, Laure, Granville, Sophie, Issorat, Elodie, Broissand, Christine, Alyanakian, Marie-Alexandra, Geri, Guillaume, Derridj, Nawal, Sguiouar, Naima, Meddah, Hakim, Djadel, Mourad, Chambrin-Lauvray, Héléne, Duclos-vallée, Jean-Charles, Saliba, Faouzi, Sacleux, Sophie-Caroline, Kounis, Ilias, Tamazirt, Sonia, Rudant, Eric, Michot, Jean-Marie, Stoclin, Annabelle, Colomba, Emeline, Pommeret, Fanny, Willekens, Christophe, Da Silva, Rosa, Dejean, Valérie, Mekid, Yasmina, Ben-Mabrouk, Ines, Netzer, Florence, Pradon, Caroline, Drouard, Laurence, Camara-Clayette, Valérie, Morel, Alexandre, Garcia, Gilles, Mohebbi, Abolfazl, Berbour, Férial, Dehais, Mélanie, Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Héléne, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Chan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Marquis, Eric, Benoit, Philippe, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Helene, Mourad, Jean-Jacques, Sacco, Emmanuelle, Renet, Sophie, Ader, F., Yazdanpanah, Y., Mentre, F., Peiffer-Smadja, N., Lescure, F.X., Poissy, J., Bouadma, L., Timsit, J.F., Lina, B., Morfin-Sherpa, F., Bouscambert, M., Gaymard, A., Peytavin, G., Abel, L., Guedj, J., Andrejak, C., Burdet, C., Laouenan, C., Belhadi, D., Dupont, A., Alfaiate, T., Basli, B., Chair, A., Laribi, S., Level, J., Schneider, M., Tellier, M.C., Dechanet, A., Costagliola, D., Terrier, B., Ohana, M., Couffin-Cadiergues, S., Esperou, H., Delmas, C., Saillard, J., Fougerou, C., Moinot, L., Wittkop, L., Cagnot, C., Le Mestre, S., Lebrasseur-Longuet, D., Petrov-Sanchez, V., Diallo, A., Mercier, N., Icard, V., Leveau, B., Tubiana, S., Hamze, B., Gelley, A., Noret, M., D’Ortenzio, E., Puechal, O., Semaille, C., Welte, T., Paiva, J.A., Halanova, M., Kieny, M.P., Balssa, E., Birkle, C., Gibowski, S., Landry, E., Le Goff, A., Moachon, L., Moins, C., Wadouachi, L., Paul, C., Levier, A., Bougon, D., Djossou, F., Epelboin, L., Dellamonica, J., Marquette, C.H., Robert, C., Gibot, S., Senneville, E., Jean-Michel, V., Zerbib, Y., Chirouze, C., Boyer, A., Cazanave, C., Gruson, D., Malvy, D., Andreu, P., Quenot, J.P., Terzi, N., Faure, K., Chabartier, C., Le Moing, V., Klouche, K., Ferry, T., F, Valour, Gaborit, B., Canet, E., Le Turnier, P., Boutoille, D., Bani-Sadr, F., Benezit, F., Revest, M., Cameli, C., Caro, A., Um Tegue, MJ Ngo, Le Tulzo, Y., Laviolle, B., Laine, F., Thiery, G., Meziani, F., Hansmann, Y., Oulehri, W., Tacquard, C., Vardon-Bounes, F., Riu-Poulenc, B., Murris-Espin, M., Bernard, L., Garot, D., Hinschberger, O., Martinot, M., Bruel, C., Pilmis, B., Bouchaud, O., Loubet, P., Roger, C., Monnet, X., Figueiredo, S., Godard, V., Mira, J.P., Lachatre, M., Kerneis, S., Aboab, J., Sayre, N., Crockett, F., Lebeaux, D., Buffet, A., Diehl, J.L., Fayol, A., Hulot, J.S., Livrozet, M., Dessap, A Mekontso, Ficko, C., Stefan, F., Le Pavec, J., Mayaux, J., Ait-Oufella, H., Molina, J.M., Pialoux, G., Fartoukh, M., Textoris, J., Brossard, M., Essat, A., Netzer, E., Riault, Y., Ghislain, M., Beniguel, L., Genin, M., Gouichiche, L., Betard, C., Belkhir, L., Altdorfer, A., Centro, V Fraipont, Braz, S., Ribeiro, JM Ferreira, Alburqueque, R Roncon, Berna, M., Alexandre, M., Lamprecht, B., Egle, A., Greil, R., Joannidis, M., Patterson, Thomas F., Ponce, Philip O., Taylor, Barbara S., Patterson, Jan E., Bowling, Jason E., Javeri, Heta, Kalil, Andre C., Larson, LuAnn, Hewlett, Angela, Mehta, Aneesh K., Rouphael, Nadine G., Saklawi, Youssef, Scanlon, Nicholas, Traenkner, Jessica J., Trible, Ronald P., Jr., Walter, Emmanuel B., Ivey, Noel, Holland, Thomas L., Ruiz-Palacios, Guillermo M., Ponce de León, Alfredo, Rajme, Sandra, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Lee, Helen S., Kline, Susan, Billings, Joanne, Noren, Brooke, Kim, Hyun, Bold, Tyler D., Tapson, Victor, Grein, Jonathan, Sutterwala, Fayyaz, Iovine, Nicole, Beattie, Lars K., Wakeman, Rebecca Murray, Shaw, Matthew, Jain, Mamta K., Mocherla, Satish, Meisner, Jessica, Luque, Amneris, Sweeney, Daniel A., Benson, Constance A., Ali, Farhana, Atmar, Robert L., El Sahly, Hana M., Whitaker, Jennifer, Falsey, Ann R., Branche, Angela R., Rozario, Cheryl, Pineda, Justino Regalado, Martinez-Orozco, José Arturo, Lye, David Chien, Ong, Sean WX., Chia, Po Ying, Young, Barnaby E., Sandkovsky, Uriel, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Cantos, Valeria D., Kelley, Colleen F., Rebolledo Esteinou, Paulina A., Kandiah, Sheetal, Doernberg, Sarah B., Crouch, Pierre-Cedric B., Jang, Hannah, Luetkemeyer, Anne F., Dwyer, Jay, Cohen, Stuart H., Thompson, George R., 3rd, Nguyen, Hien H., Finberg, Robert W., Wang, Jennifer P., Perez-Velazquez, Juan, Wessolossky, Mireya, Jackson, Patrick E.H., Bell, Taison D., West, Miranda J., Taiwo, Babafemi, Krueger, Karen, Perez, Johnny, Pearson, Triniece, Paules, Catharine I., Julian, Kathleen G., Ahmad, Danish, Hajduczok, Alexander G., Arguinchona, Henry, Arguinchona, Christa, Erdmann, Nathaniel, Goepfert, Paul, Ahuja, Neera, Frank, Maria G., Wyles, David, Young, Heather, Oh, Myoung-don, Park, Wan Beom, Kang, Chang Kyung, Marconi, Vincent, Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Kim, Eu Suk, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Tan, Seow Yen, Shafi, Humaira, Chien, Jaime, Fong, Raymond KC., Murray, Daniel D., Lundgren, Jens, Nielsen, Henrik, Jensen, Tomas, Zingman, Barry S., Grossberg, Robert, Riska, Paul F., Yang, Otto O., Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R., Hauser, Naomi, Campbell, James D., Short, William R., Tebas, Pablo, Baron, Jillian T., McLellan, Susan L.F., Blanton, Lucas S., Seashore, Justin B., Creech, C. Buddy, Rice, Todd W., Walker, Shannon, Thomsen, Isaac P., Lopez de Castilla, Diego, Van Winkle, Jason W., Riedo, Francis X., Pada, Surinder Kaur, Wang, Alvin DY., Lin, Li, Harkins, Michelle, Mertz, Gregory, Sosa, Nestor, Ann Chai, Louis Yi, Tambyah, Paul Anantharajah, Tham, Sai Meng, Archuleta, Sophia, Yan, Gabriel, Lindholm, David A., Markelz, Ana Elizabeth, Mende, Katrin, Mularski, Richard, Hohmann, Elizabeth, Torres-Soto, Mariam, Jilg, Nikolaus, Maves, Ryan C., Utz, Gregory C., George, Sarah L., Hoft, Daniel F., Brien, James D., Paredes, Roger, Mateu, Lourdes, Loste, Cora, Kumar, Princy, Thornton, Sarah, Mohanraj, Sharmila, Hynes, Noreen A., Sauer, Lauren M., Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Chambers, Susan E., Novak, Richard M., Wendrow, Andrea, Gupta, Samir K., Lee, Tida, Lalani, Tahaniyat, Holodniy, Mark, Chary, Aarthi, Huprikar, Nikhil, Ganesan, Anuradha, Ohmagari, Norio, Mikami, Ayako, Price, D. Ashley, Duncan, Christopher J.A., Dierberg, Kerry, Neumann, Henry J., Taylor, Stephanie N., Lacour, Alisha, Masri, Najy, Swiatlo, Edwin, Widmer, Kyle, Neaton, James D., Bessesen, Mary, Stephens, David S., Burgess, Timothy H., Uyeki, Timothy M., Walker, Robert, Marks, G. Lynn, Osinusi, Anu, Cao, Huyen, Cardoso, Anabela, de Bono, Stephanie, Schlichting, Douglas E., Chung, Kevin K., Ferreira, Jennifer L., Green, Michelle, Makowski, Mat, Wierzbicki, Michael R., Conrad, Tom M., El-Khorazaty, Jill Ann, Hill, Heather, Bonnett, Tyler, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Beigel, John H., Tomashek, Kay M., Ghazaryan, Varduhi, Beresnev, Tatiana, Nayak, Seema, Dodd, Lori E., Dempsey, Walla, Nomicos, Effie, Lee, Marina, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Voell, Jocelyn D., Davey, Richard, Serrano, Ruth C., Wiley, Zanthia, Phadke, Varun K., Goepfert, Paul A., Gomez, Carlos A., Sofarelli, Theresa A., Certain, Laura, Imlay, Hannah N., Wolfe, Cameron R., Ko, Emily R., Engemann, John J., Felix, Nora Bautista, Wan, Claire R., Elmor, Sammy T., Bristow, Laurel R., Harkins, Michelle S., Iovine, Nicole M., Elie-Turenne, Marie-Carmelle, Tapson, Victor F., Choe, Pyoeng Gyun, Mularski, Richard A., Rhie, Kevin S., Hussein, Rezhan H., Ince, Dilek, Winokur, Patricia L., Takasaki, Jin, Saito, Sho, McConnell, Kimberly, Wyles, David L., Sarcone, Ellen, Grimes, Kevin A., Perez, Katherine, Janak, Charles, Whitaker, Jennifer A., Rebolledo, Paulina A., Gharbin, John, Lambert, Allison A., Zea, Diego F., Bainbridge, Emma, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Ling, Evelyn, Go, Minjoung, Hubbard, Fleesie A., Chakrabarty, Melony, Laguio-Vila, Maryrose, Walsh, Edward E., Guirgis, Faheem, Marconi, Vincent C., Madar, Christian, Borgetti, Scott A., Levine, Corri, Nock, Joy, Candiotti, Keith, Rozman, Julia, Dangond, Fernando, Hyvert, Yann, Seitzinger, Andrea, Cross, Kaitlyn, Pettibone, Stephanie, Nayak, Seema U., Deye, Gregory A., Siempos, Ilias I., Belhadi, Drifa, Veiga, Viviane Cordeiro, Cavalcanti, Alexandre Biasi, Branch-Elliman, Westyn, Papoutsi, Eleni, Gkirgkiris, Konstantinos, Xixi, Nikoleta A., and Kotanidou, Anastasia more...
- Published
- 2024
- Full Text
- View/download PDF
5. Circulating Proteins Associated with Anti-IL6 Receptor Therapeutic Resistance in the Sera of Patients with Severe COVID-19.
- Author
-
Michot, Jean-Marie, Dozio, Vito, Rohmer, Julien, Pommeret, Fanny, Roumier, Mathilde, Yu, Haochen, Sklodowki, Kamil, Danlos, François-Xavier, Ouali, Kaissa, Kishazi, Edina, Naigeon, Marie, Griscelli, Franck, Gachot, Bertrand, Groh, Matthieu, Bacciarello, Giulia, Stoclin, Annabelle, Willekens, Christophe, Sakkal, Madona, Bayle, Arnaud, and Zitvogel, Laurence more...
- Published
- 2024
- Full Text
- View/download PDF
6. A retrospective comparison of abbreviated course “7+7” vs standard hypomethylating agent plus venetoclax doublets in older/unfit patients with newly diagnosed acute myeloid leukemia.
- Author
-
Bazinet, Alexandre, primary, Dinardo, Courtney Denton, additional, Arani, Naszrin, additional, Bataller, Alex, additional, Rausch, Caitlin R, additional, Maiti, Abhishek, additional, Swaminathan, Mahesh, additional, Daver, Naval Guastad, additional, Kadia, Tapan M., additional, Ravandi-Kashani, Farhad, additional, Kantarjian, Hagop M., additional, Chraibi, Samy, additional, Decroocq, Justine, additional, Pascal, Laurent, additional, Lebon, Delphine, additional, Bonnet, Sarah, additional, Gauthier, Nicolas, additional, Pages, Arnaud, additional, De Botton, Stéphane, additional, and Willekens, Christophe, additional more...
- Published
- 2024
- Full Text
- View/download PDF
7. Relevance, Risks, and Benefits of Early‐Phases Clinical Trials Participations for Patients With Hematological Malignancies From 2008 to 2023.
- Author
-
Guerra, Matteo, Alouani, Emily, Hueso, Thomas, Ouali, Kaissa, Danu, Alina, Hollebecque, Antoine, Bahleda, Rastislav, Willekens, Christophe, Gazzah, Anas, Baldini, Capucine, Postel‐Vinay, Sophie, Micol, Jean‐Baptiste, Massard, Christophe, De Botton, Stéphane, Ribrag, Vincent, and Michot, Jean‐Marie more...
- Subjects
ACUTE myeloid leukemia ,HEMATOLOGIC malignancies ,MULTIPLE myeloma ,HODGKIN'S disease ,MYELODYSPLASTIC syndromes - Abstract
Background: Early‐phases clinical trials (Phases 1 and 2) have evolved from a traditional assessment of toxicity to an adaptive approach based on patients' medical needs and access to effective new therapies. The global risks, benefits, and relevance of early‐phases clinical trials participation for patients with hematological malignancies remain poorly evaluated. Patients and Methods: All early‐phases clinical trials participations for patients with hematological malignancies, from 2008 to 2023, in a tertiary academic center in Europe, were reviewed. Patient's demographics, tumor type categories, therapeutic responses, mortality, overall survival (OS), and investigational product (IP) were assessed. Results: Over the period 2008–2023, 736 patients participating in 92 different early‐phases clinical trials, were analyzed. The most common tumor categories were diffuse large B‐cell lymphoma (n = 253; 34.4%), acute myeloid leukemia/myelodysplastic syndrome (n = 164; 22.3%) and multiple myeloma (n = 100; 13.6%). The median OS was 14.8 (95% CI: 12.4–17.9) months and response rate 31.9%, including complete responses in 13.5% of patients. By tumor categories, the highest and lowest median duration of OS were observed for patients with Hodgkin lymphoma (99.8; [95% CI: 47.0‐not reached] months) and peripheral T‐cell lymphoma (8.9 [95% CI: 5.3–12.0] months), respectively. The on‐protocol and treatment‐related mortality rates were 5.43% and 0.54%, respectively. Overall response rate was 29.1% including 13.5% of complete response. Overall, 202 (27.5%) patients received an IP later approved by the health authorities, and those patients had better OS (18.2 months vs. 12.1 months HR: 1.160 [95% CI; 0.6977–1.391], p = 0.0283). Conclusion: In conclusion, patients with hematologic malignancies who have participated in early‐phases clinical trials over the past 15 years have achieved variable therapeutic response rates, acceptable risk/benefit ratio and potentially significant therapeutic advantages. This study provides framework material for hematologists to further discuss clinical trial participation with their patients. [ABSTRACT FROM AUTHOR] more...
- Published
- 2025
- Full Text
- View/download PDF
8. Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19
- Author
-
Silvin, Aymeric, Chapuis, Nicolas, Dunsmore, Garett, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Almire, Carole, Hénon, Clémence, Kosmider, Olivier, Droin, Nathalie, Rameau, Philippe, Catelain, Cyril, Alfaro, Alexia, Dussiau, Charles, Friedrich, Chloé, Sourdeau, Elise, Marin, Nathalie, Szwebel, Tali-Anne, Cantin, Delphine, Mouthon, Luc, Borderie, Didier, Deloger, Marc, Bredel, Delphine, Mouraud, Severine, Drubay, Damien, Andrieu, Muriel, Lhonneur, Anne-Sophie, Saada, Véronique, Stoclin, Annabelle, Willekens, Christophe, Pommeret, Fanny, Griscelli, Frank, Ng, Lai Guan, Zhang, Zheng, Bost, Pierre, Amit, Ido, Barlesi, Fabrice, Marabelle, Aurélien, Pène, Frédéric, Gachot, Bertrand, André, Fabrice, Zitvogel, Laurence, Ginhoux, Florent, Fontenay, Michaela, and Solary, Eric more...
- Published
- 2020
- Full Text
- View/download PDF
9. CXCL8 secreted by immature granulocytes inhibits wildtype hematopoiesis in chronic myelomonocytic leukemia
- Author
-
Deschamps, Paul, primary, Wacheux, Margaux, additional, Gosseye, Axel, additional, Morabito, Margot, additional, Pagès, Arnaud, additional, Lyne, Anne-Marie, additional, Alfaro, Alexia, additional, Rameau, Philippe, additional, Imanci, Aygun, additional, Chelbie, Rabie, additional, Marchand, Valentine, additional, Renneville, Aline, additional, Patnaik, Mrinal, additional, Lapierre, Valerie, additional, Badaoui, Bouchra, additional, Wagner-Ballon, Orianne, additional, Berthon, Céline, additional, Braun, Thorsten, additional, Willekens, Christophe, additional, Itzykson, Raphael, additional, Fenaux, Pierre, additional, Thépot, Sylvain, additional, Etienne, Gabriel, additional, Porteu, Francoise, additional, Elvira-Matelot, Emilie, additional, Droin, Nathalie, additional, Perié, Leïla, additional, Laplane, Lucie, additional, Solary, Eric, additional, and Selimoglu-Buet, Dorothée, additional more...
- Published
- 2024
- Full Text
- View/download PDF
10. Determinants of the outcomes of patients with cancer infected with SARS-CoV-2: results from the Gustave Roussy cohort
- Author
-
Albiges, Laurence, Foulon, Stéphanie, Bayle, Arnaud, Gachot, Bertrand, Pommeret, Fanny, Willekens, Christophe, Stoclin, Annabelle, Merad, Mansouria, Griscelli, Frank, Lacroix, Ludovic, Netzer, Florence, Hueso, Thomas, Balleyguier, Corinne, Ammari, Samy, Colomba, Emeline, Baciarello, Giulia, Perret, Audrey, Hollebecque, Antoine, Hadoux, Julien, Michot, Jean-Marie, Chaput, Nathalie, Saada, Veronique, Hauchecorne, Mathilde, Micol, Jean-Baptiste, Sun, Roger, Valteau-Couanet, Dominique, André, Fabrice, Scotte, Florian, Besse, Benjamin, Soria, Jean-Charles, and Barlesi, Fabrice more...
- Published
- 2020
- Full Text
- View/download PDF
11. Impact of Arsenic Trioxide in the Treatment of Higher Risk Acute Promyelocytic Leukemia
- Author
-
Da Rocha, Audrey, primary, Cassinat, Bruno, additional, Heiblig, Mael, additional, Recher, Christian, additional, Bertoli, Sarah, additional, Bonmati, Caroline, additional, Roth-Guepin, Gabrielle, additional, Zilliox, Anne, additional, Laloi, Marie, additional, Hunault, Mathilde, additional, Berthon, Céline, additional, Duployez, Nicolas, additional, Willekens, Christophe, additional, Gallego Hernanz, Maria Pilar, additional, Ochmann, Marlene, additional, Cluzeau, Thomas, additional, Chermat, Fatiha, additional, Caulier, Alexis, additional, Raffoux, Emmanuel, additional, Fenaux, Pierre, additional, Marolleau, Jean Pierre, additional, Ades, Lionel, additional, and Lebon, Delphine, additional more...
- Published
- 2023
- Full Text
- View/download PDF
12. IDH1 and IDH2 Mutations as Novel Therapeutic Targets in Acute Myeloid Leukemia (AML): Current Perspectives
- Author
-
Paci, Angelo, primary, Heiblig, Mael, additional, Willekens, Christophe, additional, Broutin, Sophie, additional, Touat, Mehdi, additional, Penard-Lacronique, Virginie, additional, and de Bottona, Stéphane, additional more...
- Published
- 2020
- Full Text
- View/download PDF
13. ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia
- Author
-
Maes, Tamara, Mascaró, Cristina, Tirapu, Iñigo, Estiarte, Angels, Ciceri, Filippo, Lunardi, Serena, Guibourt, Nathalie, Perdones, Alvaro, Lufino, Michele M.P., Somervaille, Tim C.P., Wiseman, Dan H., Duy, Cihangir, Melnick, Ari, Willekens, Christophe, Ortega, Alberto, Martinell, Marc, Valls, Nuria, Kurz, Guido, Fyfe, Matthew, Castro-Palomino, Julio Cesar, and Buesa, Carlos more...
- Published
- 2018
- Full Text
- View/download PDF
14. Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia
- Author
-
Lucas, Nolwenn, Duchmann, Matthieu, Rameau, Philippe, Noël, Floriane, Michea, Paula, Saada, Véronique, Kosmider, Olivier, Pierron, Gérard, Fernandez-Zapico, Martin E, Howard, Matthew T., King, Rebecca L., Niyongere, Sandrine, Diop, M’boyba Khadija, Fenaux, Pierre, Itzykson, Raphael, Willekens, Christophe, Ribrag, Vincent, Fontenay, Michaela, Padron, Eric, Soumelis, Vassili, Droin, Nathalie, Patnaik, Mrinal M, and Solary, Eric more...
- Published
- 2019
- Full Text
- View/download PDF
15. Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers
- Author
-
Danlos, François-Xavier, Grajeda-Iglesias, Claudia, Durand, Sylvère, Sauvat, Allan, Roumier, Mathilde, Cantin, Delphine, Colomba, Emeline, Rohmer, Julien, Pommeret, Fanny, Baciarello, Giulia, Willekens, Christophe, Vasse, Marc, Griscelli, Frank, Fahrner, Jean-Eudes, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Nirmalathasan, Nitharsshini, Bredel, Delphine, Mouraud, Séverine, Pradon, Caroline, Stoclin, Annabelle, Rozenberg, Flore, Duchemin, Jérôme, Jourdi, Georges, Ellouze, Syrine, Levavasseur, Françoise, Albigès, Laurence, Soria, Jean-Charles, Barlesi, Fabrice, Solary, Eric, André, Fabrice, Pène, Frédéric, Ackerman, Félix, Mouthon, Luc, Zitvogel, Laurence, Marabelle, Aurélien, Michot, Jean-Marie, Fontenay, Michaela, and Kroemer, Guido more...
- Published
- 2021
- Full Text
- View/download PDF
16. Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia
- Author
-
Stein, Eytan M., DiNardo, Courtney D., Pollyea, Daniel A., Fathi, Amir T., Roboz, Gail J., Altman, Jessica K., Stone, Richard M., DeAngelo, Daniel J., Levine, Ross L., Flinn, Ian W., Kantarjian, Hagop M., Collins, Robert, Patel, Manish R., Frankel, Arthur E., Stein, Anthony, Sekeres, Mikkael A., Swords, Ronan T., Medeiros, Bruno C., Willekens, Christophe, Vyas, Paresh, Tosolini, Alessandra, Xu, Qiang, Knight, Robert D., Yen, Katharine E., Agresta, Sam, de Botton, Stephane, and Tallman, Martin S. more...
- Published
- 2017
- Full Text
- View/download PDF
17. Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines
- Author
-
Zhang, Yanyan, He, Liang, Selimoglu-Buet, Dorothée, Jego, Chloe, Morabito, Margot, Willekens, Christophe, Diop, M'boyba Khadija, Gonin, Patrick, Lapierre, Valérie, Droin, Nathalie, Solary, Eric, and Louache, Fawzia more...
- Published
- 2017
- Full Text
- View/download PDF
18. Venetoclax–proteasome inhibitor–dexamethasone for unfit patients with blastic plasmacytoid dendritic cell neoplasm
- Author
-
Khalife-Hachem, Sabine, Pages, Arnaud, Akoury, Elie, Bonnet, Sarah, Birsen, Rudy, Busquet, Clémence, Contejean, Adrien, Danu, Alina, de Botton, Stéphane, de Charrette, Marie, Dumas, Pierre Yves, Jaccard, Arnaud, Marfaing-Koka, Anne, Willekens, Christophe, Deconinck, Eric, and Ghez, David more...
- Published
- 2024
- Full Text
- View/download PDF
19. Mutational profiling of isolated myeloid sarcomas and utility of serum 2HG as biomarker of IDH1/2 mutations
- Author
-
Willekens, Christophe, Renneville, Aline, Broutin, Sophie, Saada, Véronique, Micol, Jean-Baptiste, Delahousse, Julia, Poinsignon, Vianney, Bories, Claire, Berthon, Céline, Itzykson, Raphael, Boissel, Nicolas, Quivoron, Cyril, Terroir-Cassou-Mounat, Marie, Bosq, Jacques, Preudhomme, Claude, Paci, Angelo, Penard-Lacronique, Virginie, and De Botton, Stéphane more...
- Published
- 2018
- Full Text
- View/download PDF
20. Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib
- Author
-
Quek, Lynn, David, Muriel D., Kennedy, Alison, Metzner, Marlen, Amatangelo, Michael, Shih, Alan, Stoilova, Bilyana, Quivoron, Cyril, Heiblig, Maël, Willekens, Christophe, Saada, Véronique, Alsafadi, Samar, Vijayabaskar, M. S., Peniket, Andy, Bernard, Oliver A., Agresta, Sam, Yen, Katharine, MacBeth, Kyle, Stein, Eytan, Vassiliou, George S., Levine, Ross, De Botton, Stephane, Thakurta, Anjan, Penard-Lacronique, Virginie, and Vyas, Paresh more...
- Published
- 2018
- Full Text
- View/download PDF
21. When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes
- Author
-
Willekens, Christophe, primary, Chahine, Claude, additional, Dragani, Matteo, additional, Khalife‐Hachem, Sabine, additional, Bigenwald, Camille, additional, Rossignol, Julien, additional, Castilla‐Llorente, Cristina, additional, Danu, Alina, additional, Michot, Jean‐Marie, additional, Saada, Veronique, additional, Cotteret, Sophie, additional, Marzac, Christophe, additional, Renneville, Aline, additional, Plo, Isabelle, additional, Broutin, Sophie, additional, Bosselut, Nelly, additional, Cassinat, Bruno, additional, Lazarovici, Julien, additional, Droin, Nathalie, additional, and De Botton, Stephane, additional more...
- Published
- 2023
- Full Text
- View/download PDF
22. SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice
- Author
-
Willekens, Christophe, primary, Laplane, Lucie, additional, Dagher, Tracy, additional, Benlabiod, Camelia, additional, Papadopoulos, Nicolas, additional, Lacout, Catherine, additional, Rameau, Philippe, additional, Catelain, Cyril, additional, Alfaro, Alexia, additional, Edmond, Valérie, additional, Signolle, Nicolas, additional, Marchand, Valentine, additional, Droin, Nathalie, additional, Hoogenboezem, Remco, additional, Schneider, Rebekka K., additional, Penson, Alex, additional, Abdel-Wahab, Omar, additional, Giraudier, Stephane, additional, Pasquier, Florence, additional, Marty, Caroline, additional, Plo, Isabelle, additional, Villeval, Jean-Luc, additional, Constantinescu, Stefan N., additional, Porteu, Françoise, additional, Vainchenker, William, additional, and Solary, Eric, additional more...
- Published
- 2023
- Full Text
- View/download PDF
23. RBD- specific Th1 responses are associated with vaccine-induced protection against SARS-CoV-2 infection in patients with hematological malignancies
- Author
-
Bigenwald, Camille, primary, Haddad, Yacine, additional, Thelemaque, Cassandra, additional, Carrier, Agathe, additional, Birebent, Roxanne, additional, Ly, Pierre, additional, Flament, Caroline, additional, Lahmar, Imran, additional, de Sousa, Eric, additional, Maeurer, Markus, additional, Miyara, Makoto, additional, Assi, Tarek, additional, Castilla-Llorente, Cristina, additional, Willekens, Christophe, additional, Fayemi, Céline, additional, Lazarovici, Julien, additional, Marabelle, Aurélien, additional, Derosa, Lisa, additional, Ribrag, Vincent, additional, and Zitvogel, Laurence, additional more...
- Published
- 2023
- Full Text
- View/download PDF
24. Concurrent Etoposide, Steroid, High-dose Ara-C and Platinum chemotherapy with radiation therapy in localised extranodal natural killer (NK)/T-cell lymphoma, nasal type
- Author
-
Michot, Jean-Marie, Mazeron, Renaud, Danu, Alina, Lazarovici, Julien, Ghez, David, Antosikova, Anna, Willekens, Christophe, Chamseddine, Ali N., Minard, Veronique, Dartigues, Peggy, Bosq, Jacques, Carde, Patrice, Koscielny, Serge, De Botton, Stéphane, Ferme, Christophe, Girinsky, Theodore, and Ribrag, Vincent more...
- Published
- 2015
- Full Text
- View/download PDF
25. Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia
- Author
-
Selimoglu-Buet, Dorothée, Wagner-Ballon, Orianne, Saada, Véronique, Bardet, Valérie, Itzykson, Raphaël, Bencheikh, Laura, Morabito, Margot, Met, Elisabeth, Debord, Camille, Benayoun, Emmanuel, Nloga, Anne-Marie, Fenaux, Pierre, Braun, Thorsten, Willekens, Christophe, Quesnel, Bruno, Adès, Lionel, Fontenay, Michaela, Rameau, Philippe, Droin, Nathalie, Koscielny, Serge, and Solary, Eric more...
- Published
- 2015
- Full Text
- View/download PDF
26. Outcome of patients with high risk Myelodysplastic Syndrome (MDS) and advanced Chronic Myelomonocytic Leukemia (CMML) treated with decitabine after azacitidine failure
- Author
-
Harel, Stéphanie, Cherait, Amina, Berthon, Céline, Willekens, Christophe, Park, Sophie, Rigal, Marthe, Brechignac, Sabine, Thépot, Sylvain, Quesnel, Bruno, Gardin, Claude, Adès, Lionel, Fenaux, Pierre, and Braun, Thorsten more...
- Published
- 2015
- Full Text
- View/download PDF
27. SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice
- Author
-
Solary, Eric, primary, Willekens, Christophe, additional, Laplane, Lucie, additional, Dragher, Tracy, additional, Benlabiod, Camelia, additional, Papadopoulos, Nicolas, additional, LAcout, Catherine, additional, Rameau, Philippe, additional, Catelain, Cyril, additional, Alfaro, Alexia, additional, Edmond, Valerie, additional, Signolle, Nicolas, additional, Marchand, Valentine, additional, Droin, Nathalie, additional, Hoogenboezem, Remco, additional, Schneider, Rebekka, additional, Penson, Alex, additional, Abdel-Wahab, Omar, additional, GIRAUDIER, Stéphane, additional, Pasquier, Florence, additional, Marty, Caroline, additional, Plo, Isabelle, additional, Villeval, Jean Luc, additional, Constantinescu, Stefan N., additional, Porteu, Francoise, additional, and Vainchenker, William, additional more...
- Published
- 2022
- Full Text
- View/download PDF
28. Reduced Venetoclax Exposition to Seven Days of Azacitidine Is Efficient in Treatment-Naïve Patients with Acute Myeloid Leukemia
- Author
-
Willekens, Christophe, primary, Chraibi, Samy, additional, Decroocq, Justine, additional, Carpentier, Benjamin, additional, Lebon, Delphine, additional, Bonnet, Sarah, additional, Gauthier, Nicolas, additional, Pagès, Arnaud, additional, Dragani, Matteo, additional, Khalife-Hachem, Sabine, additional, Micol, Jean-Baptiste, additional, Pasquier, Florence, additional, Wickenhauser, Stefan, additional, Saada, Véronique, additional, Vergé, Véronique, additional, Arbab, Ahmadreza, additional, Marzac, Christophe, additional, Pascal, Laurent, additional, Roos-Weil, Damien, additional, Jourdan, Eric, additional, Bouscary, Didier, additional, and de Botton, Stéphane, additional more...
- Published
- 2022
- Full Text
- View/download PDF
29. JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation
- Author
-
Besancenot, Rodolphe, Roos-Weil, Damien, Tonetti, Carole, Abdelouahab, Hadjer, Lacout, Catherine, Pasquier, Florence, Willekens, Christophe, Rameau, Philippe, Lecluse, Yann, Micol, Jean-Baptiste, Constantinescu, Stefan N., Vainchenker, William, Solary, Eric, and Giraudier, Stéphane more...
- Published
- 2014
- Full Text
- View/download PDF
30. Invasive cutaneous infection due to Scopulariopsis brevicaulis unsuccessfully treated with high-dose micafungin in a neutropenic patient
- Author
-
Gavril, Daniela, Woerther, Paul-Louis, Ben Lakhdar, Aicha, Mahjoubi, Linda, Routier, Emilie, Chachaty, Elisabeth, Gachot, Bertrand, De Botton, Stephane, Micol, Jean-Baptiste, and Willekens, Christophe more...
- Published
- 2017
- Full Text
- View/download PDF
31. SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes
- Author
-
Willekens, Christophe, primary, Laplane, Lucie, additional, Dagher, Tracy, additional, Benlabiod, Camélia, additional, Lacout, Catherine, additional, Rameau, Philippe, additional, Catelain, Cyril, additional, Alfaro, Alexia, additional, Edmond, Valérie, additional, Signolle, Nicolas, additional, Silvin, Aymeric, additional, Ginhoux, Florent, additional, Marchand, Valentine, additional, Droin, Nathalie, additional, Hoogenboezem, Remco, additional, Schneider, Rebekka K., additional, Penson, Alexander V, additional, Abdel-Wahab, Omar, additional, Gonin, Patrick, additional, Marty, Caroline, additional, Plo, Isabelle, additional, Villeval, Jean-Luc, additional, Porteu, Francoise, additional, Vainchenker, William, additional, and Solary, Eric, additional more...
- Published
- 2021
- Full Text
- View/download PDF
32. Bendamustine and rituximab combination in the management of chronic lymphocytic leukemia-associated autoimmune hemolytic anemia: A multicentric retrospective study of the French CLL intergroup (GCFLLC/MW and GOELAMS)
- Author
-
Quinquenel, Anne, Willekens, Christophe, Dupuis, Jehan, Royer, Bruno, Ysebaert, Loic, Guibert, De S., Michallet, Anne-Sophie, Feugier, Pierre, Guieze, Romain, Levy, Vincent, and Delmer, Alain
- Published
- 2015
- Full Text
- View/download PDF
33. Prognosis and monitoring of core-binding factor acute myeloid leukemia: current and emerging factors
- Author
-
Duployez, Nicolas, Willekens, Christophe, Marceau-Renaut, Alice, Boudry-Labis, Elise, and Preudhomme, Claude
- Published
- 2015
- Full Text
- View/download PDF
34. Molecular Landscape of Therapy-related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers
- Author
-
Khalife-Hachem, Sabine, primary, Saleh, Khalil, additional, Pasquier, Florence, additional, Willekens, Christophe, additional, Tarabay, Anthony, additional, Antoun, Leony, additional, Grinda, Thomas, additional, Castilla-Llorente, Cristina, additional, Duchmann, Matthieu, additional, Quivoron, Cyril, additional, Auger, Nathalie, additional, Saada, Veronique, additional, Delaloge, Suzette, additional, Leary, Alexandra, additional, Renneville, Aline, additional, Antony-Debre, Ileana, additional, Rosselli, Filippo, additional, De Botton, Stéphane, additional, Salviat, Flore, additional, Marzac, Christophe, additional, and Micol, Jean-Baptiste, additional more...
- Published
- 2021
- Full Text
- View/download PDF
35. Evolution clonale: qu’est-ce qu’un clone?
- Author
-
Jourdain, Antoine, Duchmann, Matthieu, Willekens, Christophe, Solary, Eric, Perié, Leïla, Laplane, Lucie, Institut d'Histoire et de Philosophie des Sciences et des Techniques (IHPST), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Loison, Laurent, and Pradeu, Thomas more...
- Subjects
[SHS.HISPHILSO]Humanities and Social Sciences/History, Philosophy and Sociology of Sciences ,[SDV]Life Sciences [q-bio] - Published
- 2021
36. Coopération entre les mutations Jak2 V617F et Srsf2 P95Hdans le système hématopoïétique
- Author
-
Willekens, Christophe and STAR, ABES
- Subjects
[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology ,SRSF2 ,JAK2 ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Signalisation ,Modèles murins ,Épissage ,Signalling ,Neoplasmes myéloprolifératifs ,Splicing ,Myeloproliferative neoplasms ,Mouse model - Abstract
JAK2 V617F mutation is frequently identified in myeloproliferative neoplasms (MPN). Additional somatic variants are supposed to contribute to bone marrow fibrosis or acute myeloid leukemia evolution. One of these mutations affects SRSF2, a gene encoding a component of the splicing machinery. To investigate how Jak2 V617F and Srsf2 P95H mutations interact in the hematopoietic tissue, we generated conditional knock-in mice in which the two mutations were expressed upon the control of Scl gene. Our study shows that Srsf2 P95H mutation initially exhibits limited effect on Jak2 V617F polycythemia and thrombocytosis but induces a delay in myelofibrosis development and protect hematopoietic stem cell from exhaustion observed after serial transplantation in Jak2 V617F single mutant cells. We focused on megakaryocyte (MK), implied in fibrosis development and found that Srsf2P95H partially reversed MKabnormalities induced by Jak2 V617F (cell size, normalized ploidy and expression of c-Mpl). Analysis of c-Mpl/Jak2 signaling with mass cytometry revealed a slight reduced proportion of MK expressing high levels of P-Stat5 in case of Srsf2 P95H co-occurrence with Jak2 V617F while treatment with high dose of the thrombopoietin-mimetic romiplostim in mice transplanted with wild-type or Srsf2 P95H bone marrow cells confirms the negative impact of Srsf2 P95H on fibrosis development. Gene expression analysis on sorted MK confirms down-regulation of Jak/Stat signaling pathway induced by Srsf2 P95H and reveals that Srsf2 P95H mutation more frequently induces exon 14 skipping of Jak2 mRNA. These result was confirmed in granulocytes samples from patients with JAK2 V617F MPN with associated SRSF2 P95H mutation., La mutation JAK2 V617F est fréquemment observée en cas de néoplasme myéloprolifératif (NMP). D’autres mutations somatiques peuvent être associées et sont corrélées au stade myélofibrotique ou à une évolution en leucémie aigüe. L’une de ces mutations touche le gène SRSF2, codant pour une protéine du complexe d’épissage. Pour étudier l’interaction entre les mutations Jak2 V617F et Srsf2 P95H dans le tissu hématopoïétique, nous avons généré un modèle murin knock-in conditionnel des deux mutations s’exprimant sous le contrôle du gène Scl. Notre étude montre que Srsf2 P95H limite peu le développement de la polyglobulie et de la thrombocytose induites par Jak2 V617F mais freine l’évolution vers une fibrose médullaire et protège les cellules souches hématopoïétiques de l’épuisement en transplantations sériées. L’étude des mégacaryocytes (MK), impliqués dans le processus fibrotique, montre que Srsf2 P95H induit une quasi-normalisation des anomalies induites par Jak2 V617F (taille, ploïdisation, expression de c-Mpl). L’analyse de la signalisation c-Mpl/Jak2 par cytométrie de masse révèle une discrète diminution de la proportion de MK exprimant de haut niveau de P-Stat5 en cas de mutation Srsf2 P95H associée à Jak2 V617F tandis que l’injection d’un agoniste de la thrombopoïetine à fortes doses confirme l’impact négatif de Srsf2 P95H sur le développement de la fibrose. L’étude de l’expression génique de MK triés confirme l’altération de la voie Jak/Stat induite par Srsf2 P95H et révèle que Srsf2 P95H induit plus fréquemment une perte de l’exon 14 (incluant la mutation V617F) de l’ARNm de Jak2. Ce résultat est confirmé sur des échantillons de granulocytes de patients atteints de NMP JAK2 V617F avec mutation SRSF2 P95H associée. more...
- Published
- 2021
37. 1-Year Data Analysis from a Cancer Center Molecular Tumor Board Dedicated to Clonal Hematopoiesis
- Author
-
Micol, Jean-Baptiste, Arbab, Ahmadreza, Vasseur, Damien, Bayle, Arnaud, Aldea, Mihaela, Loyaux, Romain, Verge, Veronique, Saada, Veronique, Fievet, Alice, Auger, Nathalie, Cotteret, Sophie, Pasquier, Florence, Willekens, Christophe, Bigenwald, Camille, Castilla-Llorente, Cristina, De Botton, Stephane, Solary, Eric, Bernard, Elsa, Rouleau, Etienne, Italiano, Antoine, Marzac, Christophe, and Renneville, Aline more...
- Published
- 2023
- Full Text
- View/download PDF
38. Minimal residual disease monitoring in t(8;21) acute myeloid leukemia based on RUNX1-RUNX1T1 fusion quantification on genomic DNA
- Author
-
Duployez, Nicolas, Nibourel, Olivier, Marceau-Renaut, Alice, Willekens, Christophe, Helevaut, Nathalie, Caillault, Aurélie, Villenet, Céline, Celli-Lebras, Karine, Boissel, Nicolas, Jourdan, Eric, Dombret, Hervé, Figeac, Martin, Preudhomme, Claude, and Renneville, Aline more...
- Published
- 2014
- Full Text
- View/download PDF
39. Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative study
- Author
-
Kayser, Sabine, primary, Schlenk, Richard F., additional, Lebon, Delphine, additional, Carre, Martin, additional, Götze, Katharina S., additional, Stölzel, Friedrich, additional, Berceanu, Ana, additional, Schäfer-Eckart, Kerstin, additional, Peterlin, Pierre, additional, Hicheri, Yosr, additional, Rahme, Ramy, additional, Raffoux, Emmanuel, additional, Chermat, Fatiha, additional, Krause, Stefan W., additional, Aulitzky, Walter E., additional, Rigaudeau, Sophie, additional, Noppeney, Richard, additional, Berthon, Celine, additional, Görner, Martin, additional, Jost, Edgar, additional, Carassou, Philippe, additional, Keller, Ulrich, additional, Orvain, Corentin, additional, Braun, Thorsten, additional, Saillard, Colombe, additional, Arar, Ali, additional, Kunzmann, Volker, additional, Wemeau, Mathieu, additional, De Wit, Maike, additional, Niemann, Dirk, additional, Bonmati, Caroline, additional, Schwänen, Carsten, additional, Abraham, Julie, additional, Aljijakli, Ahmad, additional, Haiat, Stephanie, additional, Krämer, Alwin, additional, Reichle, Albrecht, additional, Gnadler, Martina, additional, Willekens, Christophe, additional, Spiekermann, Karsten, additional, Hiddemann, Wolfgang, additional, Müller-Tidow, Carsten, additional, Thiede, Christian, additional, Röllig, Christoph, additional, Serve, Hubert, additional, Bornhäuser, Martin, additional, Baldus, Claudia D., additional, Lengfelder, Eva, additional, Fenaux, Pierre, additional, Platzbecker, Uwe, additional, and Adès, Lionel, additional more...
- Published
- 2021
- Full Text
- View/download PDF
40. First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia
- Author
-
Salamero, Olga, Montesinos, Pau, Willekens, Christophe, Pérez-Simón, José Antonio, Pigneux, Arnaud, Récher, Christian, Popat, Rakesh, Carpio Segura, Cecilia del Carmen, Molinero, César, Mascaró, Cristina, Vila, Joaquim, Arévalo, M. Isabel, Maes, Tamara, Buesa, Carlos, Bosch José, Francesc Xavier, The University of Manchester, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Salamero O, Carpio C, Bosch F] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Montesinos P] Hospital Universitari I Politécnic La Fe, València, Spain. Centro de Investigación Biomédica en Red de Cáncer, Instituto Carlos III, Madrid, Spain. [Willekens C] Institut Gustave Roussy, Villejuif Cedex, France. [Pérez-Simón JA] Hospital Universitario Virgen del Rocío, Sevilla, Spain. Instituto de Biomedicina de Sevilla (Insitituto de Biomedicina De Sevilla/Consejo Superior De Investigaciones Científicas/Centro de Investigación Biomédica en Red de Cáncer), Universidad de Sevilla, Sevilla, Spain. [Pigneux A] Centre Hospitalier Universitaire CHU Bordeaux, Hôpital du Haut Lévêque, Pessac, France. [Récher C] Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Université Toulouse III Paul Sabatier, Toulouse, France, Vall d'Hebron Barcelona Hospital Campus, Ministerio de Economía y Competitividad (España), European Commission, Cancer Research UK, Centro para el Desarrollo Tecnológico Industrial (España), National Institute for Health Research (UK), University College London, and NIHR Biomedical Research Centre (UK) more...
- Subjects
Adult ,Male ,Cancer Research ,Myeloid ,Lysine-Specific Histone Demethylase 1A ,acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos [COMPUESTOS QUÍMICOS Y DROGAS] ,neoplasias::neoplasias por tipo histológico::leucemia::leucemia mieloide::leucemia mieloide aguda [ENFERMEDADES] ,Refractory ,In vivo ,Recurrence ,hemic and lymphatic diseases ,medicine ,Hematologic Malignancy ,Humans ,Other subheadings::/therapeutic use [Other subheadings] ,Enzyme Inhibitors ,Aged ,Aged, 80 and over ,Histone Demethylases ,business.industry ,Leucèmia mieloide aguda ,Otros calificadores::/uso terapéutico [Otros calificadores] ,Myeloid leukemia ,Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myeloid, Acute [DISEASES] ,KDM1A ,ORIGINAL REPORTS ,Middle Aged ,medicine.disease ,In vitro ,Leukemia ,Leukemia, Myeloid, Acute ,medicine.anatomical_structure ,Oncology ,Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors [CHEMICALS AND DRUGS] ,Cancer research ,Female ,business ,Inhibidors enzimàtics - Ús terapèutic - Abstract
[Purpose] Iadademstat is a novel, highly potent, and selective inhibitor of LSD1 (KDM1A), with preclinical in vitro and in vivo antileukemic activity. This study aimed to determine safety and tolerability of iadademstat as monotherapy in patients with relapsed/refractory acute myeloid leukemia (R/R AML)., [Methods] This phase I, nonrandomized, open-label, dose-escalation (DE), and extension-cohort (EC) trial included patients with R/R AML and evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antileukemic activity of this orally bioavailable first-in-class lysine-specific demethylase 1 inhibitor., [Results] Twenty-seven patients were treated with iadademstat on days 1 to 5 (5-220 µg/m2/d) of each week in 28-day cycles in a DE phase that resulted in a recommended dose of 140 µg/m2/d of iadademstat as a single agent. This dose was chosen to treat all patients (n = 14) in an EC enriched with patients with MLL/KMT2A-rearranged AML. Most adverse events (AEs) were as expected in R/R AML and included myelosuppression and nonhematologic AEs, such as infections, asthenia, mucositis, and diarrhea. PK data demonstrated a dose-dependent increase in plasma exposure, and PD data confirmed a potent time- and exposure-dependent induction of differentiation biomarkers. Reductions in blood and bone marrow blast percentages were observed, together with induction of blast cell differentiation, in particular, in patients with MLL translocations. One complete remission with incomplete count recovery was observed in the DE arm., [Conclusion] Iadademstat exhibits a good safety profile together with signs of clinical and biologic activity as a single agent in patients with R/R AML. A phase II trial of iadademstat in combination with azacitidine is ongoing (EudraCT No.: 2018-000482-36)., Supported by Oryzon Genomics and IPT-2012-0673-010000 of the INNPACTO program of the Spanish Ministry of Economy and Competitiveness, with contribution of Fondo Europeo de Desarrollo Regional (FEDER) from the European Union and CDTI_CIIP-20131005/EUROSTAR_E18159. T.C.P.S. is supported by Cancer Research UK Grant No. C5759/A20971. R.P. is supported by the National Institute for Health Research, University College London Hospitals, Biomedical Research Centre. more...
- Published
- 2020
41. Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study
- Author
-
Kayser, Sabine, Schlenk, Richard F., Lebon, Delphine, Carre, Martin, Götze, Katharina S., Stölzel, Friedrich, Berceanu, Ana, Schäfer-Eckart, Kerstin, Peterlin, Pierre, Hicheri, Yosr, Rahme, Ramy, Raffoux, Emmanuel, Chermat, Fatiha, Krause, Stefan W., Aulitzky, Walter E., Rigaudeau, Sophie, Noppeney, Richard, Berthon, Celine, Görner, Martin, Jost, Edgar, Carassou, Philippe, Keller, Ulrich, Orvain, Corentin, Braun, Thorsten, Saillard, Colombe, Arar, Ali, Kunzmann, Volker, Wemeau, Mathieu, De Wit, Maike, Niemann, Dirk, Bonmati, Caroline, Schwänen, Carsten, Abraham, Julie, Aljijakli, Ahmad, Haiat, Stephanie, Krämer, Alwin, Reichle, Albrecht, Gnadler, Martina, Willekens, Christophe, Spiekermann, Karsten, Hiddemann, Wolfgang, Müller-Tidow, Carsten, Thiede, Christian, Röllig, Christoph, Serve, Hubert, Bornhäuser, Martin, Baldus, Claudia D., Lengfelder, Eva, Fenaux, Pierre, Platzbecker, Uwe, and Adès, Lionel more...
- Subjects
ddc - Published
- 2020
42. Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: the role of mucosal strengthening
- Author
-
Hueso, Thomas, Ekpe, Kenneth, Mayeur, Camille, Gatse, Anna, Joncquel-Chevallier Curt, Marie, Gricourt, Guillaume, Rodriguez, Christophe, Burdet, Charles, Ulmann, Guillaume, Neut, Christel, Amini, Salah-Eddine, Lepage, Patricia, Raynard, Bruno, Willekens, Christophe, Micol, Jean-Baptiste, de Botton, Stéphane, Yakoub-Agha, Ibrahim, Gottrand, Frédéric, Desseyn, Jean-Luc, Thomas, Muriel, Woerther, Paul-Louis, Seguy, David, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de Lille (CHU Lille), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Emergence de la résistance bactérienne in vivo (EA3964), Université Paris Diderot - Paris 7 (UPD7), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy], Institut Gustave Roussy (IGR), Département d’Innovation Thérapeutique et essais précoces [Gustave Roussy] (DITEP), Centre hospitalier universitaire Henri-Mondor [Créteil], Dynamic Microbiology - EA 7380 (DYNAMIC), École nationale vétérinaire - Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est (UPE)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille], Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University Hospital of Lille, MSD, École nationale vétérinaire d'Alfort (ENVA)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Lille, and Tâche, Roselyne more...
- Subjects
Adult ,Male ,[SDV]Life Sciences [q-bio] ,Mice, Transgenic ,chemotherapy ,Feces ,Mice ,mucus ,Antineoplastic Combined Chemotherapy Protocols ,microbiota ,Animals ,Humans ,acute leukemia ,Intestinal Mucosa ,lcsh:RC799-869 ,Aged ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Induction Chemotherapy ,Middle Aged ,Fatty Acids, Volatile ,Gastrointestinal Microbiome ,[SDV] Life Sciences [q-bio] ,Leukemia, Myeloid, Acute ,intestinal barrier ,Dysbiosis ,Female ,lcsh:Diseases of the digestive system. Gastroenterology ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Research Article ,Research Paper - Abstract
International audience; Induction chemotherapy (7 + 3 regimen) remains the gold standard for patients with acute myeloid leukemia (AML) but is responsible for gut damage leading to several complications such as bloodstream infection (BSI). We aimed to investigate the impact of induction chemotherapy on the intestinal barrier of patients with AML and in wild-type mice. Next, we assessed the potential benefit of strengthening the mucosal barrier in transgenic mice releasing a recombinant protein able to reinforce the mucus layer (Tg222). In patients, we observed a decrease of plasma citrulline, which is a marker of the functional enterocyte mass, of short-chain fatty acids and of fecal bacterial load, except forEscherichia coliandEnterococcusspp., which became dominant. Both the alpha and beta-diversities of fecal microbiota decreased. In wild-type mice, citrulline levels decreased under chemotherapy along with an increase ofE. coliandEnterococcusspp load associated with concomitant histologic impairment. By comparison with wild-type mice, Tg222 mice, 3 days after completing chemotherapy, had higher citrulline levels, a faster healing epithelium, and preserved alpha-diversity of their intestinal microbiota. This was associated with reduced bacterial translocations. Our results highlight the intestinal damage and the dysbiosis induced by the 7 + 3 regimen. As a proof of concept, our transgenic model suggests that strengthening the intestinal barrier is a promising approach to limit BSI and improve AML patients' outcome. more...
- Published
- 2020
- Full Text
- View/download PDF
43. First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia
- Author
-
Universidad de Sevilla. Departamento de Medicina, Salamero, Olga, Montesinos, Pau, Willekens, Christophe, Pérez Simón, José Antonio, Pigneux, Arnaud, Récher, Christian, Somervaille, Tim C.P., Universidad de Sevilla. Departamento de Medicina, Salamero, Olga, Montesinos, Pau, Willekens, Christophe, Pérez Simón, José Antonio, Pigneux, Arnaud, Récher, Christian, and Somervaille, Tim C.P. more...
- Abstract
PURPOSE Iadademstat is a novel, highly potent, and selective inhibitor of LSD1 (KDM1A), with preclinical in vitro and in vivo antileukemic activity. This study aimed to determine safety and tolerability of iadademstat as monotherapy in patients with relapsed/refractory acute myeloid leukemia (R/R AML). METHODS This phase I, nonrandomized, open-label, dose-escalation (DE), and extension-cohort (EC) trial included patients with R/R AML and evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antileukemic activity of this orally bioavailable first-in-class lysine-specific demethylase 1 inhibitor. RESULTS Twenty-seven patients were treated with iadademstat on days 1 to 5 (5-220 µg/m2/d) of each week in 28-day cycles in a DE phase that resulted in a recommended dose of 140 µg/m2/d of iadademstat as a single agent. This dose was chosen to treat all patients (n = 14) in an EC enriched with patients with MLL/KMT2A-rearranged AML. Most adverse events (AEs) were as expected in R/R AML and included myelosuppression and nonhematologic AEs, such as infections, asthenia, mucositis, and diarrhea. PK data demonstrated a dose-dependent increase in plasma exposure, and PD data confirmed a potent time- and exposure-dependent induction of differentiation biomarkers. Reductions in blood and bone marrow blast percentages were observed, together with induction of blast cell differentiation, in particular, in patients with MLL translocations. One complete remission with incomplete count recovery was observed in the DE arm. CONCLUSION Iadademstat exhibits a good safety profile together with signs of clinical and biologic activity as a single agent in patients with R/R AML. A phase II trial of iadademstat in combination with azacitidine is ongoing . more...
- Published
- 2020
44. First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia
- Author
-
Ministerio de Economía y Competitividad (España), European Commission, Cancer Research UK, Centro para el Desarrollo Tecnológico Industrial (España), National Institute for Health Research (UK), University College London, NIHR Biomedical Research Centre (UK), Salamero, Olga, Montesinos, Pau, Willekens, Christophe, Pérez-Simón, José A., Pigneux, Arnaud, Récher, Christian, Popat, Rakesh, Carpio, Cecilia, Molinero, César, Mascaró, Cristina, Vila Grajales, Joaquim, Arévalo, M. Isabel, Maes, Tamara, Buesa, Carlos, Bosch, Francesc, Somervaille, Tim C. P., Ministerio de Economía y Competitividad (España), European Commission, Cancer Research UK, Centro para el Desarrollo Tecnológico Industrial (España), National Institute for Health Research (UK), University College London, NIHR Biomedical Research Centre (UK), Salamero, Olga, Montesinos, Pau, Willekens, Christophe, Pérez-Simón, José A., Pigneux, Arnaud, Récher, Christian, Popat, Rakesh, Carpio, Cecilia, Molinero, César, Mascaró, Cristina, Vila Grajales, Joaquim, Arévalo, M. Isabel, Maes, Tamara, Buesa, Carlos, Bosch, Francesc, and Somervaille, Tim C. P. more...
- Abstract
[Purpose] Iadademstat is a novel, highly potent, and selective inhibitor of LSD1 (KDM1A), with preclinical in vitro and in vivo antileukemic activity. This study aimed to determine safety and tolerability of iadademstat as monotherapy in patients with relapsed/refractory acute myeloid leukemia (R/R AML)., [Methods] This phase I, nonrandomized, open-label, dose-escalation (DE), and extension-cohort (EC) trial included patients with R/R AML and evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antileukemic activity of this orally bioavailable first-in-class lysine-specific demethylase 1 inhibitor., [Results] Twenty-seven patients were treated with iadademstat on days 1 to 5 (5-220 µg/m2/d) of each week in 28-day cycles in a DE phase that resulted in a recommended dose of 140 µg/m2/d of iadademstat as a single agent. This dose was chosen to treat all patients (n = 14) in an EC enriched with patients with MLL/KMT2A-rearranged AML. Most adverse events (AEs) were as expected in R/R AML and included myelosuppression and nonhematologic AEs, such as infections, asthenia, mucositis, and diarrhea. PK data demonstrated a dose-dependent increase in plasma exposure, and PD data confirmed a potent time- and exposure-dependent induction of differentiation biomarkers. Reductions in blood and bone marrow blast percentages were observed, together with induction of blast cell differentiation, in particular, in patients with MLL translocations. One complete remission with incomplete count recovery was observed in the DE arm., [Conclusion] Iadademstat exhibits a good safety profile together with signs of clinical and biologic activity as a single agent in patients with R/R AML. A phase II trial of iadademstat in combination with azacitidine is ongoing (EudraCT No.: 2018-000482-36). more...
- Published
- 2020
45. ATG2B/GSKIP in de novo acute myeloid leukemia (AML): high prevalence of germline predisposition in French West Indies
- Author
-
Pegliasco, Jean, primary, Schmaltz-Panneau, Barbara, additional, Martin, Jean-Edouard, additional, Chraibi, Samy, additional, Khalife-Hachem, Sabine, additional, Salviat, Flore, additional, Pasquier, Florence, additional, Willekens, Christophe, additional, Lopez, Maureen, additional, Ben-ali, Adel, additional, Bera, Odile, additional, Caron, Olivier, additional, Castilla-Llorent, Cristina, additional, Cotteret, Sophie, additional, Bourdin, Carole, additional, Saada, Veronique, additional, Auger, Nathalie, additional, de Botton, Stephane, additional, Vainchenker, William, additional, Fuseau, Pascal, additional, Helias, Philippe, additional, Benabdelali, Raouf, additional, Marzac, Christophe, additional, Meniane, Jean-Come, additional, Plo, Isabelle, additional, Bellanné-Chantelot, Christine, additional, and Micol, Jean-Baptiste, additional more...
- Published
- 2021
- Full Text
- View/download PDF
46. Attenuated cytarabine, etoposide, dexamethasone plus rituximab (R‐Mini‐CYVE) regimen for patients with relapsed or refractory B‐cell non–Hodgkin’s lymphoma not eligible for intensive chemotherapy
- Author
-
Abdayem, Pamela, primary, Ibrahim, Nathalie, additional, El Dakdouki, Yolla, additional, Willekens, Christophe, additional, Ghez, David, additional, A. Rouche, Julia, additional, Dartigues, Peggy, additional, Desmaris, Romain, additional, Danu, Alina, additional, Rossignol, Julien, additional, Lazarovici, Julien, additional, Fermé, Christophe, additional, Ribrag, Vincent, additional, and Michot, Jean M., additional more...
- Published
- 2021
- Full Text
- View/download PDF
47. Prognostic value of PINI index in patients with multiple myeloma
- Author
-
Dupire, Sophie, Wemeau, Mathieu, Debarri, Houria, Pascal, Laurent, Hivert, Benedicte, Willekens, Christophe, Boyle, Eileen, Manier, Salomon, Béatrice, Thielemans, Onraed, Brigitte, Faucompré, Jean-Luc, Hennache, Bernadette, Dumontet, Charles, Facon, Thierry, and Leleu, Xavier more...
- Published
- 2012
- Full Text
- View/download PDF
48. Inherited transmission of the CSF3R T618I mutational hotspot in familial chronic neutrophilic leukemia
- Author
-
Duployez, Nicolas, Willekens, Christophe, Plo, Isabelle, Marceau-Renaut, Alice, de Botton, Stéphane, Fenwarth, Laurène, Boyer, Thomas, Huet, Guillemette, Nibourel, Olivier, Rose, Christian, Nelken, Brigitte, Quesnel, Bruno, and Preudhomme, Claude more...
- Published
- 2019
- Full Text
- View/download PDF
49. Low dose IL-2 in patients with steroid-dependent dysimmune manifestations associated with myelodysplastic syndromes: a three-case report
- Author
-
Corfmat, Marion, primary, Willekens, Christophe, additional, Vinit, Julien, additional, Bussone, Guillaume, additional, Fenaux, Pierre, additional, Fain, Olivier, additional, Klatzmann, David, additional, Mekinian, Arsene, additional, and Comont, Thibault, additional more...
- Published
- 2020
- Full Text
- View/download PDF
50. Enasidenib for the treatment of relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase 2 mutation
- Author
-
Heiblig, Mael, primary, Hachem-Khalife, Sabine, additional, Willekens, Christophe, additional, Micol, Jean-Baptiste, additional, Paci, Angelo, additional, Penard-Lacronique, Virginie, additional, and de Botton, Stéphane, additional more...
- Published
- 2020
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.