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867 results on '"Willemze, Rein"'

3. EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome – Update 2023

Author

Latzka, Johanna, Assaf, Chalid, Bagot, Martine, Cozzio, Antonio, Dummer, Reinhard, Guenova, Emmanuella, Gniadecki, Robert, Hodak, Emmilia, Jonak, Constanze, Klemke, Claus-Detlev, Knobler, Robert, Morrris, Stephen, Nicolay, Jan P., Ortiz-Romero, Pablo L., Papadavid, Evangelia, Pimpinelli, Nicola, Quaglino, Pietro, Ranki, Annamari, Scarisbrick, Julia, Stadler, Rudolf, Väkevä, Liisa, Vermeer, Maarten H., Wehkamp, Ulrike, Whittaker, Sean, Willemze, Rein, and Trautinger, Franz

Published
2023
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5. Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC

Author

Olsen, Elise A., Whittaker, Sean, Willemze, Rein, Pinter-Brown, Lauren, Foss, Francine, Geskin, Larisa, Schwartz, Lawrence, Horwitz, Steven, Guitart, Joan, Zic, John, Kim, Youn H., Wood, Gary S., Duvic, Madeleine, Ai, Wei, Girardi, Michael, Gru, Alejandro, Guenova, Emmanuella, Hodak, Emmilia, Hoppe, Richard, Kempf, Werner, Kim, Ellen, Lechowicz, Mary Jo, Ortiz-Romero, Pablo, Papadavid, Evangelia, Quaglino, Pietro, Pittelkow, Mark, Prince, H. Miles, Sanches, Jose Antonio, Sugaya, Makoto, Vermeer, Maarten, Zain, Jasmine, Knobler, Robert, Stadler, Rudolf, Bagot, Martine, and Scarisbrick, Julia

Published
2022
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15. Evaluation of Quality of Life and Treatment Satisfaction in Newly Diagnosed Cutaneous T-Cell Lymphoma Patients.

Author

Ottevanger, Rosanne, van Beugen, Sylvia, Kersten, Juliette M., Evers, Andrea W. M., Vermeer, Maarten H., Willemze, Rein, and Quint, Koen D.

Subjects
PAIN measurement, ACADEMIC medical centers, RESEARCH funding, VISUAL analog scale, QUESTIONNAIRES, MYCOSIS fungoides, TREATMENT effectiveness, DESCRIPTIVE statistics, SEZARY syndrome, LONGITUDINAL method, ITCHING, CUTANEOUS T-cell lymphoma, QUALITY of life, PATIENT satisfaction, CANCER patient psychology, CANCER fatigue, PATIENTS' attitudes, DISEASE complications
Abstract

Simple Summary: This study provides an insight into newly diagnosed patients with MF on patients' expectations, quality of life, and treatment satisfaction. These data can be used for adequate expectation management and provide a rationale for further evaluation of treatment regimens in these patients. Background: Little is known about the impact of MF on quality of life (QoL) in newly diagnosed patients. Objectives: To describe the impact of the MF diagnosis on QoL, patient expectations, and treatment satisfaction over the first 6 months after diagnosis. Methods: Outcomes of this prospective cohort study of newly diagnosed MF patients conducted between 2020 and 2022 at the Leiden University Medical Center included the Skindex-29, RAND-12 Health Survey, degree of itch, pain, and fatigue (Visual Analogue Scale (VAS)), patient expectations, and Client Satisfaction Questionnaire-8 (CSQ-8), measured at baseline and after six months. Results: A total of 28 patients with MF were included. At baseline, 66% (n = 18) "strongly-totally" expected positive effects of the treatment. At the time of diagnosis, 28% of the patients (n = 8) were moderately to severely affected. There was no statistical change in the Skindex-29 score sum score (20 [10–34] vs. 20 [9–36]; p = 0.81) or in the other three subdomains, the RAND-12 scores, and the VAS itch, pain, and fatigue over time. Treatment satisfaction was high overall. Conclusion: Despite that the newly diagnosed MF patients anticipate a positive treatment effect, few improvements in QoL and symptom reduction were found. These data can be used for adequate expectation management and provide a rationale for further evaluation of treatment regimens in these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Detection of circulating tumor DNA in liquid biopsies of patients with primary cutaneous diffuse large B-cell lymphoma, leg type

Author

Schrader, Anne, primary, van Engeland, Julia, additional, Quint, Koen, additional, Willemze, Rein, additional, Vermaat, Joost, additional, Ottevanger, Rosanne, additional, Kersten, Juliette, additional, Zoutman, Wim, additional, Jansen, Patty, additional, van Egmond, Demi, additional, Versluis-Lops, Mieke, additional, and Vermeer, Maarten, additional

Published
2023
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22. Data from Dietary Immunosuppressants Do Not Enhance UV-Induced Skin Carcinogenesis, and Reveal Discordance between p53-Mutant Early Clones and Carcinomas

Author

Voskamp, Pieter, primary, Bodmann, Carolien A, primary, Koehl, Gudrun E, primary, Rebel, Heggert G., primary, Van Olderen, Marjolein G.E., primary, Gaumann, Andreas, primary, El Ghalbzouri, Abdoel, primary, Tensen, Cornelis P., primary, Bavinck, Jan N. Bouwes, primary, Willemze, Rein, primary, Geissler, Edward K., primary, and De Gruijl, Frank R., primary

Published
2023
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23. Supplementary Table 1, Figures 1 - 4 from Dietary Immunosuppressants Do Not Enhance UV-Induced Skin Carcinogenesis, and Reveal Discordance between p53-Mutant Early Clones and Carcinomas

Author

Voskamp, Pieter, primary, Bodmann, Carolien A, primary, Koehl, Gudrun E, primary, Rebel, Heggert G., primary, Van Olderen, Marjolein G.E., primary, Gaumann, Andreas, primary, El Ghalbzouri, Abdoel, primary, Tensen, Cornelis P., primary, Bavinck, Jan N. Bouwes, primary, Willemze, Rein, primary, Geissler, Edward K., primary, and De Gruijl, Frank R., primary

Published
2023
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24. European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome – Update 2017

Author

Trautinger, Franz, Eder, Johanna, Assaf, Chalid, Bagot, Martine, Cozzio, Antonio, Dummer, Reinhard, Gniadecki, Robert, Klemke, Claus-Detlev, Ortiz-Romero, Pablo L., Papadavid, Evangelia, Pimpinelli, Nicola, Quaglino, Pietro, Ranki, Annamari, Scarisbrick, Julia, Stadler, Rudolf, Väkevä, Liisa, Vermeer, Maarten H., Whittaker, Sean, Willemze, Rein, and Knobler, Robert

Published
2017
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26. Data from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome

Author

Vermeer, Maarten H., primary, van Doorn, Remco, primary, Dijkman, Remco, primary, Mao, Xin, primary, Whittaker, Sean, primary, van Voorst Vader, Pieter C., primary, Gerritsen, Marie-Jeanne P., primary, Geerts, Marie-Louise, primary, Gellrich, Sylke, primary, Söderberg, Ola, primary, Leuchowius, Karl-Johan, primary, Landegren, Ulf, primary, Out-Luiting, Jacoba J., primary, Knijnenburg, Jeroen, primary, IJszenga, Marije, primary, Szuhai, Karoly, primary, Willemze, Rein, primary, and Tensen, Cornelis P., primary

Published
2023
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27. Supplementary Figure 1 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome

Author

Vermeer, Maarten H., primary, van Doorn, Remco, primary, Dijkman, Remco, primary, Mao, Xin, primary, Whittaker, Sean, primary, van Voorst Vader, Pieter C., primary, Gerritsen, Marie-Jeanne P., primary, Geerts, Marie-Louise, primary, Gellrich, Sylke, primary, Söderberg, Ola, primary, Leuchowius, Karl-Johan, primary, Landegren, Ulf, primary, Out-Luiting, Jacoba J., primary, Knijnenburg, Jeroen, primary, IJszenga, Marije, primary, Szuhai, Karoly, primary, Willemze, Rein, primary, and Tensen, Cornelis P., primary

Published
2023
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28. Supplementary Table 4 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome

Author

Vermeer, Maarten H., primary, van Doorn, Remco, primary, Dijkman, Remco, primary, Mao, Xin, primary, Whittaker, Sean, primary, van Voorst Vader, Pieter C., primary, Gerritsen, Marie-Jeanne P., primary, Geerts, Marie-Louise, primary, Gellrich, Sylke, primary, Söderberg, Ola, primary, Leuchowius, Karl-Johan, primary, Landegren, Ulf, primary, Out-Luiting, Jacoba J., primary, Knijnenburg, Jeroen, primary, IJszenga, Marije, primary, Szuhai, Karoly, primary, Willemze, Rein, primary, and Tensen, Cornelis P., primary

Published
2023
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29. Supplementary Table 3 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome

Author

Vermeer, Maarten H., primary, van Doorn, Remco, primary, Dijkman, Remco, primary, Mao, Xin, primary, Whittaker, Sean, primary, van Voorst Vader, Pieter C., primary, Gerritsen, Marie-Jeanne P., primary, Geerts, Marie-Louise, primary, Gellrich, Sylke, primary, Söderberg, Ola, primary, Leuchowius, Karl-Johan, primary, Landegren, Ulf, primary, Out-Luiting, Jacoba J., primary, Knijnenburg, Jeroen, primary, IJszenga, Marije, primary, Szuhai, Karoly, primary, Willemze, Rein, primary, and Tensen, Cornelis P., primary

Published
2023
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30. Supplementary Table 2 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome

Author

Vermeer, Maarten H., primary, van Doorn, Remco, primary, Dijkman, Remco, primary, Mao, Xin, primary, Whittaker, Sean, primary, van Voorst Vader, Pieter C., primary, Gerritsen, Marie-Jeanne P., primary, Geerts, Marie-Louise, primary, Gellrich, Sylke, primary, Söderberg, Ola, primary, Leuchowius, Karl-Johan, primary, Landegren, Ulf, primary, Out-Luiting, Jacoba J., primary, Knijnenburg, Jeroen, primary, IJszenga, Marije, primary, Szuhai, Karoly, primary, Willemze, Rein, primary, and Tensen, Cornelis P., primary

Published
2023
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31. Supplementary Table 1 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome

Author

Vermeer, Maarten H., primary, van Doorn, Remco, primary, Dijkman, Remco, primary, Mao, Xin, primary, Whittaker, Sean, primary, van Voorst Vader, Pieter C., primary, Gerritsen, Marie-Jeanne P., primary, Geerts, Marie-Louise, primary, Gellrich, Sylke, primary, Söderberg, Ola, primary, Leuchowius, Karl-Johan, primary, Landegren, Ulf, primary, Out-Luiting, Jacoba J., primary, Knijnenburg, Jeroen, primary, IJszenga, Marije, primary, Szuhai, Karoly, primary, Willemze, Rein, primary, and Tensen, Cornelis P., primary

Published
2023
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33. Unmet Clinical Needs and Management Recommendations for Blastic Plasmacytoid Dendritic Cell Neoplasm: A Consensus-based Position Paper From an Ad Hoc International Expert Panel

Author

Pagano, Livio, primary, Zinzani, Pier Luigi, additional, Pileri, Stefano, additional, Quaglino, Pietro, additional, Cuglievan, Branko, additional, Berti, Emilio, additional, Pemmaraju, Naveen, additional, Onida, Francesco, additional, Willemze, Rein, additional, Orfao, Alberto, additional, and Barosi, Giovanni, additional

Published
2023
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41. Genetic Stability of Driver Alterations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type and Their Relapses: A Rationale for the Use of Molecular-Based Methods for More Effective Disease Monitoring

Author

Schrader, Anne M. R., primary, de Groen, Ruben A. L., additional, Willemze, Rein, additional, Jansen, Patty M., additional, Quint, Koen D., additional, Cleven, Arjen H. G., additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Ruano, Dina, additional, Veelken, J. H. (Hendrik), additional, Tensen, Cornelis P., additional, Neelis, Karen J., additional, Daniels, Laurien A., additional, Hauben, Esther, additional, Woei-A-Jin, F. J. S. H. (Sherida), additional, Busschots, A. M. (Annemie), additional, Vermeer, Maarten H., additional, and Vermaat, Joost S. P., additional

Published
2022
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42. Tumor Clone Frequency Calculation Using High-Throughput Sequencing of the TCRβ Gene in Patients with Folliculotropic Mycosis Fungoides

Author

van Santen, Suzanne, primary, Zoutman, Willem H., additional, de Masson, Adèle, additional, Quint, Koen D., additional, Willemze, Rein, additional, Gerard, Nega, additional, Teague, Jessica E., additional, Kupper, Thomas S., additional, Clark, Rachael A., additional, Tensen, Cornelis P., additional, and Vermeer, Maarten H., additional

Published
2022
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46. Clinical, histopathological and prognostic features of primary cutaneous acral CD8 + T‐cell lymphoma and other dermal CD8 + cutaneous lymphoproliferations: results of an EORTC Cutaneous Lymphoma Group workshop*

Author

Kempf, Werner, primary, Petrella, Tony, additional, Willemze, Rein, additional, Jansen, Patty, additional, Berti, Emilio, additional, Santucci, Marco, additional, Geissinger, Eva, additional, Cerroni, Lorenzo, additional, Maubec, Eve, additional, Battistella, Maxime, additional, Goodlad, John, additional, Guenova, Emmanuella, additional, Lappalainen, Katariina, additional, Ranki, Annamari, additional, Craig, Paul, additional, Calonje, Eduardo, additional, Martin, Blanca, additional, Whittaker, Sean, additional, Oschlies, Ilske, additional, Wehkamp, Ulrike, additional, Nicolay, Jan P., additional, Wobser, Marion, additional, Scarisbruck, Julia, additional, Pimpinelli, Nicola, additional, Stadler, Rudi, additional, Kerl French, Katrin, additional, Quaglino, Pietro, additional, Lin, Jinran, additional, Chen, Lianjun, additional, Beer, Michaela, additional, Emanuel, Patrick, additional, Dalle, Stephane, additional, and Robson, Alistair, additional

Published
2022
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48. Quality of Life in Cutaneous T-cell Lymphoma Patients Receiving Mogamulizumab: Important Factors to Consider.

Author

Ottevanger, Rosanne, van Beugen, Sylvia, Evers, Andrea W. M., Willemze, Rein, Vermeer, Maarten H., and Quint, Koen D.

Subjects
THERAPEUTIC use of monoclonal antibodies, THERAPEUTIC use of antineoplastic agents, CANCER patient psychology, ACADEMIC medical centers, MOTIVATION (Psychology), FUNCTIONAL status, PATIENT satisfaction, HEALTH outcome assessment, PATIENTS' attitudes, QUALITY of life, QUESTIONNAIRES, RESEARCH funding, EMOTIONS, CUTANEOUS T-cell lymphoma, LONGITUDINAL method, SYMPTOMS
Abstract

Simple Summary: Patients with erythrodermic cutaneous T-cell lymphoma often experience severe symptoms. This study provides an insight into the impact of the disease, mogamulizumab treatment, and essential patient-reported outcomes. The data on patients' expectation, quality of life, and treatment satisfaction can especially be used in the counseling of future patients. Background: Erythrodermic cutaneous T-cell lymphoma (E-CTCL) is associated with a poor prognosis and severe symptoms. Objective: To establish insights into the quality of life (QoL), expectations, and treatment satisfaction of E-CTCL patients receiving mogamulizumab. Methods: Outcomes of this prospective cohort study conducted between September 2020 and August 2021 at the Leiden University Medical Center included the dermatology-specific QoL (Skindex-29), health-related QoL (RAND-12), degree of itch, pain, and fatigue (Visual Analogue Scale), patient's expectations, and treatment satisfaction (Client Satisfaction Questionnaire-8 (CSQ-8)), measured at baseline and after six months. Results: 13 patients with E-CTCL were included. Most patients anticipated a positive treatment effect on symptoms. Five patients (46%) improved one or more clinical categories regarding the symptoms domain, six (55%) regarding emotions, four (36%) regarding functioning, and four (36%) regarding the overall Skindex-29 score compared to baseline. The Mental Component Score clinically improved from 31 (IQR 29–51) at baseline to 38 (IQR 25–51). The median VAS itch improved significantly from baseline (8 (IQR 7–10) vs. 3 (IQR 1–8), p = 0.024). Most patients (n = 7) were "very satisfied" with their treatment. Limitations: There was a limited number of patients due to the rarity of the disease. Conclusion: In general, mogamulizumab has a favorable effect on biochemical- and dermatology-specific QoL and physical functioning in some patients, with high treatment satisfaction. Itch especially improved over time in most patients. The treatment satisfaction was generally high. Mogamulizumab seems to be an effective treatment that improves the QoL in patients with E-CTCL. [ABSTRACT FROM AUTHOR]

Published
2023
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