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316 results on '"Williams, D. Clive"'

2. Synthesis and Pro-Apoptotic Effects of Nitrovinylanthracenes and Related Compounds in Chronic Lymphocytic Leukaemia (CLL) and Burkitt’s Lymphoma (BL)

Author

Byrne, Andrew J., primary, Bright, Sandra A., additional, McKeown, James. P., additional, Bergin, Adam, additional, Twamley, Brendan, additional, McElligott, Anthony M., additional, Noorani, Sara, additional, Kandwal, Shubhangi, additional, Fayne, Darren, additional, O’Boyle, Niamh M., additional, Williams, D. Clive, additional, and Meegan, Mary J., additional

Published
2023
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3. Data from The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia

Author

McElligott, Anthony M., primary, Maginn, Elaina N., primary, Greene, Lisa M., primary, McGuckin, Siobhan, primary, Hayat, Amjad, primary, Browne, Paul V., primary, Butini, Stefania, primary, Campiani, Giuseppe, primary, Catherwood, Mark A., primary, Vandenberghe, Elisabeth, primary, Williams, D. Clive, primary, Zisterer, Daniela M., primary, and Lawler, Mark, primary

Published
2023
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4. Supplementary Figure 1 from The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia

Author

McElligott, Anthony M., primary, Maginn, Elaina N., primary, Greene, Lisa M., primary, McGuckin, Siobhan, primary, Hayat, Amjad, primary, Browne, Paul V., primary, Butini, Stefania, primary, Campiani, Giuseppe, primary, Catherwood, Mark A., primary, Vandenberghe, Elisabeth, primary, Williams, D. Clive, primary, Zisterer, Daniela M., primary, and Lawler, Mark, primary

Published
2023
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5. Supplementary Figure Legend from The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia

Author

McElligott, Anthony M., primary, Maginn, Elaina N., primary, Greene, Lisa M., primary, McGuckin, Siobhan, primary, Hayat, Amjad, primary, Browne, Paul V., primary, Butini, Stefania, primary, Campiani, Giuseppe, primary, Catherwood, Mark A., primary, Vandenberghe, Elisabeth, primary, Williams, D. Clive, primary, Zisterer, Daniela M., primary, and Lawler, Mark, primary

Published
2023
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7. Correction: Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics

Author

Keane, Páraic M., primary, Zehe, Clara, additional, Poynton, Fergus E., additional, Bright, Sandra A., additional, Estayalo-Adrián, Sandra, additional, Devereux, Stephen J., additional, Donaldson, Paul M., additional, Sazanovich, Igor V., additional, Towrie, Michael, additional, Botchway, Stanley W., additional, Cardin, Christine J., additional, Williams, D. Clive, additional, Gunnlaugsson, Thorfinnur, additional, Long, Conor, additional, Kelly, John M., additional, and Quinn, Susan J., additional

Published
2023
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10. Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics.

Author

Keane, Páraic M., Zehe, Clara, Poynton, Fergus E., Bright, Sandra A., Estayalo-Adrián, Sandra, Devereux, Stephen J., Donaldson, Paul M., Sazanovich, Igor V., Towrie, Michael, Botchway, Stanley W., Cardin, Christine J., Williams, D. Clive, Gunnlaugsson, Thorfinnur, Long, Conor, Kelly, John M., and Quinn, Susan J.

Abstract

Cationic porphyrins based on the 5,10,15,20-meso-(tetrakis-4-N-methylpyridyl) core (TMPyP4) have been studied extensively over many years due to their strong interactions with a variety of nucleic acid structures, and their potential use as photodynamic therapeutic agents and telomerase inhibitors. In this paper, the interactions of metal-free TMPyP4 and Pt(II)TMPyP4 with guanine-containing nucleic acids are studied for the first time using time-resolved infrared spectroscopy (TRIR). In D2O solution (where the metal-free form exists as D2TMPyP4) both compounds yielded similar TRIR spectra (between 1450–1750 cm−1) following pulsed laser excitation in their Soret B-absorption bands. Density functional theory calculations reveal that vibrations centred on the methylpyridinium groups are responsible for the dominant feature at ca. 1640 cm−1. TRIR spectra of D2TMPyP4 or PtTMPyP4 in the presence of guanosine 5'-monophosphate (GMP), double-stranded {d(GC)5}2 or {d(CGCAAATTTGCG)}2 contain negative-going signals, 'bleaches', indicative of binding close to guanine. TRIR signals for D2TMPyP4 or PtTMPyP bound to the quadruplex-forming cMYC sequence {d(TAGGGAGGG)}2T indicate that binding occurs on the stacked guanines. For D2TMPyP4 bound to guanine-containing systems, the TRIR signal at ca. 1640 cm−1 decays on the picosecond timescale, consistent with electron transfer from guanine to the singlet excited state of D2TMPyP4, although IR marker bands for the reduced porphyrin/oxidised guanine were not observed. When PtTMPyP is incorporated into HeLa tumour cells, TRIR studies show protein binding with time-dependent ps/ns changes in the amide absorptions demonstrating TRIR's potential for studying light-activated molecular processes not only with nucleic acids in solution but also in biological cells. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Effect of Alkyl Chain Length on the Photophysical, Photochemical, and Photobiological Properties of Ruthenium(II) Polypyridyl Complexes for Their Application as DNA-Targeting, Cellular-Imaging, and Light-Activated Therapeutic Agents

Author

Estalayo-Adrián, Sandra, primary, Blasco, Salvador, additional, Bright, Sandra A., additional, McManus, Gavin J., additional, Orellana, Guillermo, additional, Williams, D. Clive, additional, Kelly, John M., additional, and Gunnlaugsson, Thorfinnur, additional

Published
2021
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21. Real‐Time Multi‐Photon Tracking and Bioimaging of Glycosylated Theranostic Prodrugs upon Specific Enzyme Triggered Release.

Author

Calatrava‐Pérez, Elena, Marchetti, Luke A., McManus, Gavin J., Lynch, Dylan M., Elmes, Robert B. P., Williams, D. Clive, Gunnlaugsson, Thorfinnur, and Scanlan, Eoin M.

Subjects
PRODRUGS, ENZYMES, COMPANION diagnostics, PHARMACOKINETICS, ANTINEOPLASTIC agents
Abstract

Real‐time tracking of prodrug uptake, delivery and activation in vivo represents a major challenge for prodrug development. Herein, we demonstrate the use of novel glycosylated theranostics of the cancer pharmacophore Amonafide in highly‐selective, enzymatic triggered release. We show that the use of endogenous enzymes for activated release of the therapeutic component can be observed, in real time, and monitored using one and two‐photon bioimaging, offering unique insight into the prodrug pharmacokinetic profile. Furthermore, we demonstrate that the potent cytotoxicity of Amonafide is preserved using this targeted approach. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Membrane cholesterol modulates serotonin transporter activity

Author

Scanlon, Siobhan M., Williams, D. Clive, and Schloss, Patrick

Subjects
Serotoninergic mechanisms -- Analysis, Biological transport -- Physiological aspects, Cholesterol -- Physiological aspects, Enzymes -- Regulation, Biological sciences, Chemistry
Abstract

Results demonstrate that the transporter activity of the neurotransmitter serotonin requires specific binding of cholesterol. The binding stabilizes the protein in its fully active form.

Published
2001

29. 4-Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomal cellular imaging agents: The effect of substituent patterns on PET directional quenching.

Author

Martínez-Calvo, Miguel, Bright, Sandra A., Veale, Emma B., Henwood, Adam F., Williams, D. Clive, and Gunnlaugsson, Thorfinnur

Abstract

Four new fluorescent sensors (1–4) based on the 4-amino-1,8-naphthalimide fluorophores (Naps) have been synthesized based on the classical fluorophorespacer-receptor model. These four compounds all gave rise to emission bands centred at ca. 535 nm, which were found to be highly pH dependent, the emission being 'switched on' in acidic media, while being quenched due to PET from the amino moieties to the excited state of the Nap at more alkaline pH. The luminescent pH dependence for these probes was found to be highly dependent on the substitution on the imide site, as well as the polyamine chain attached to the position 4-amino moiety. In the case of sensor 2 the presence of the 4-amino-aniline dominated the pH dependent quenching. Nevertheless, at higher pH, PET quenching was also found to occur from the polyamine site. Hence, 2 is better described as a receptor1-spacer1-fluorophore-spacer2-receptor2 system, where the dominant PET process is due to (normally less favourable) 'directional' PET quenching from the 4-amino-aniline unit to the Nap site. Similar trends and pH fluorescence dependences were also seen for 3 and 4. These compounds were also tested for their imaging potential and toxicity against HeLa cells (using DRAQ5 as nuclear stain which does now show pH dependent changes in acidic and neutral pH) and the results demonstrated that these compounds have reduced cellular viability at moderately high concentrations (with IC50 values between ca. 8–30 µmol·L−1), but were found to be suitable for intracellular pH determination at 1 µmol ·L−1concentrations, where no real toxicity was observed. This allowed us to employ these as lysosomal probes at sub-toxic concentrations, where the Nap based emission was found to be pH depended, mirroring that seen in aqueous solution for 1–4, with the main fluorescence changes occurring within acidic to neutral pH. [ABSTRACT FROM AUTHOR]

Published
2020
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30. Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base–Ru(ii)–curcumin organometallic conjugate

Author

Shanmugaraju, Sankarasekaran, primary, la Cour Poulsen, Bjørn, additional, Arisa, Tobi, additional, Umadevi, Deivasigamani, additional, Dalton, Hannah L., additional, Hawes, Chris S., additional, Estalayo-Adrián, Sandra, additional, Savyasachi, Aramballi J., additional, Watson, Graeme W., additional, Williams, D. Clive, additional, and Gunnlaugsson, Thorfinnur, additional

Published
2018
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39. Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

Author

Fiore, Donatella, primary, Proto, Maria Chiara, additional, Pisanti, Simona, additional, Picardi, Paola, additional, Pagano Zottola, Antonio Christian, additional, Butini, Stefania, additional, Gemma, Sandra, additional, Casagni, Alice, additional, Laezza, Chiara, additional, Vitale, Mario, additional, Ligresti, Alessia, additional, Di Marzo, Vincenzo, additional, Zisterer, Daniela M., additional, Nathwani, Seema, additional, Williams, D. Clive, additional, Campiani, Giuseppe, additional, Gazzerro, Patrizia, additional, and Bifulco, Maurizio, additional

Published
2015
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40. The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications.

Author

Poynton, Fergus E., Bright, Sandra A., Blasco, Salvador, Williams, D. Clive, Kelly, John M., and Gunnlaugsson, Thorfinnur

Subjects
RUTHENIUM compounds, COMPLEX compounds, CONJUGATED polymers, IN vitro studies, SUPRAMOLECULAR chemistry, DNA analysis
Abstract

Ruthenium(ii) [Ru(ii)] polypyridyl complexes have been the focus of intense investigations since work began exploring their supramolecular interactions with DNA. In recent years, there have been considerable efforts to translate this solution-based research into a biological environment with the intention of developing new classes of probes, luminescent imaging agents, therapeutics and theranostics. In only 10 years the field has expanded with diverse applications for these complexes as imaging agents and promising candidates for therapeutics. In light of these efforts this review exclusively focuses on the developments of these complexes in biological systems, both in cells and in vivo, and hopes to communicate to readers the diversity of applications within which these complexes have found use, as well as new insights gained along the way and challenges that researchers in this field still face. [ABSTRACT FROM AUTHOR]

Published
2017
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41. Quaternarized pdppz; a novel dppz derivative that causes cellular death upon light irradiation: Synthesis, DNA-binding and biological studies

Author

Elmes, Robert B.P., Erby, Marialuisa, Cloonan, Suzanne M., Quinn, Susan J., Williams, D. Clive, and Gunnlaugsson, Thorfinnur

Abstract

The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.

Published
2011

47. Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells.

Author

Fiore, Donatella, Proto, Maria Chiara, Pisanti, Simona, Picardi, Paola, Pagano Zottola, Antonio Christian, Butini, Stefania, Gemma, Sandra, Casagni, Alice, Laezza, Chiara, Vitale, Mario, Ligresti, Alessia, Di Marzo, Vincenzo, Zisterer, Daniela M., Nathwani, Seema, Williams, D. Clive, Campiani, Giuseppe, Gazzerro, Patrizia, and Bifulco, Maurizio

Published
2016
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