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10. Climate and soils together regulate photosynthetic carbon isotope discrimination within C3 plants worldwide

Author

Cornwell, William K, Wright, Ian J, Turner, Joel, Maire, Vincent, Barbour, Margaret M, Cernusak, Lucas A, Dawson, Todd, Ellsworth, David, Farquhar, Graham D, Griffiths, Howard, Keitel, Claudia, Knohl, Alexander, Reich, Peter B, Williams, David G, Bhaskar, Radika, Cornelissen, Johannes HC, Richards, Anna, Schmidt, Susanne, Valladares, Fernando, Körner, Christian, Schulze, Ernst‐Detlef, Buchmann, Nina, and Santiago, Louis S

Subjects
Climate Action, carbon isotopes, environmental drivers, global, leaf traits, leaves, soil, Ecology
Abstract

Aim: Within C3 plants, photosynthesis is a balance between CO2 supply from the atmosphere via stomata and demand by enzymes within chloroplasts. This process is dynamic and a complex but crucial aspect of photosynthesis. We sought to understand the spatial pattern in CO2 supply–demand balance on a global scale, via analysis of stable isotopes of carbon within leaves (Δ13C), which provide an integrative record of CO2 drawdown during photosynthesis. LocationGlobal. Time period1951–2011. Major taxa studiedVascular plants. Methods: We assembled a database of leaf carbon isotope ratios containing 3,979 species–site combinations from across the globe, including 3,645 for C3 species. We examined a wide array of potential climate and soil drivers of variation in Δ13C. Results: The strongest drivers of carbon isotope discrimination at the global scale included atmospheric pressure, potential evapotranspiration and soil pH, which explained 44% of the variation in Δ13C. Addition of eight more climate and soil variables (each explaining small but highly significant amounts of variation) increased the explained variation to 60%. On top of this, the largest plant trait effect was leaf nitrogen per area, which explained 11% of Δ13C variation. Main conclusions: By considering variation in Δ13C at a considerably larger scale than previously, we were able to identify and quantify key drivers in CO2 supply–demand balance previously unacknowledged. Of special note is the key role of soil properties, with greater discrimination on low-pH and high-silt soils. Unlike other plant traits, which show typically wide variation within sets of coexisting species, the global pattern in carbon stable isotope ratios is much more conservative; there is relatively narrow variation in time-integrated CO2 concentrations at the site of carboxylation among plants in a given soil and climate.

Published
2018

22. Climate and soils together regulate photosynthetic carbon isotope discrimination within C 3 plants worldwide

Author

Cornwell, William K., Wright, Ian J., Turner, Joel, Maire, Vincent, Barbour, Margaret M., Cernusak, Lucas A., Dawson, Todd, Ellsworth, David, Farquhar, Graham D., Griffiths, Howard, Keitel, Claudia, Knohl, Alexander, Reich, Peter B., Williams, David G., Bhaskar, Radika, Cornelissen, Johannes H. C., Richards, Anna, Schmidt, Susanne, Valladares, Fernando, Körner, Christian, Schulze, Ernst-Detlef, Buchmann, Nina, and Santiago, Louis S.

Published
2018

33. Pharmacological interventions for chronic pain in children: an overview of systematic reviews

Author

Eccleston, Christopher, Fisher, Emma, Cooper, Tess E., Grégoire, Marie-Claude, Heathcote, Lauren C., Krane, Elliot, Lord, Susan M., Sethna, Navil F., Anderson, Anna-Karenia, Anderson, Brian, Clinch, Jacqueline, Gray, Andrew L., Gold, Jeffrey I., Howard, Richard F., Ljungman, Gustaf, Moore, R. Andrew, Schechter, Neil, Wiffen, Philip J., Wilkinson, Nick M.R., Williams, David G., Wood, Chantal, van Tilburg, Miranda A.L., and Zernikow, Boris

Published
2019
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38. Enabling the practices in an urban regeneration system of provision.

Author

Williams, David G.

Abstract

Urban regeneration of previously developed, or brownfield, land requires a host of competing factors to ‘fall into place’ at the same time. This includes private finance to develop and deliver a vision for how an area will develop and integrate with the existing urban fabric. Governmental support is also essential to enable the development to take place. This paper focuses on the urban regeneration of Gloucester Quays by Peel Holdings, in the south-west of the UK, and uses a combined practice theory and systems of provision approach created by Williams et al. in 2019 to explore the factors that enabled the regeneration to occur. The paper explores each level of the governance structure and the practices that influence planning and development. It demonstrates that many different factors need to fall into place to enable regeneration to take place, and the system of provision model enables the identification of these factors. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Data from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Author

Flynn, Michael J., primary, Zammarchi, Francesca, primary, Tyrer, Peter C., primary, Akarca, Ayse U., primary, Janghra, Narinder, primary, Britten, Charles E., primary, Havenith, Carin E.G., primary, Levy, Jean-Noel, primary, Tiberghien, Arnaud, primary, Masterson, Luke A., primary, Barry, Conor, primary, D'Hooge, Francois, primary, Marafioti, Teresa, primary, Parren, Paul W.H.I., primary, Williams, David G., primary, Howard, Philip W., primary, van Berkel, Patrick H., primary, and Hartley, John A., primary

Published
2023
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40. Supplemental Figure 5 from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Author

Flynn, Michael J., primary, Zammarchi, Francesca, primary, Tyrer, Peter C., primary, Akarca, Ayse U., primary, Janghra, Narinder, primary, Britten, Charles E., primary, Havenith, Carin E.G., primary, Levy, Jean-Noel, primary, Tiberghien, Arnaud, primary, Masterson, Luke A., primary, Barry, Conor, primary, D'Hooge, Francois, primary, Marafioti, Teresa, primary, Parren, Paul W.H.I., primary, Williams, David G., primary, Howard, Philip W., primary, van Berkel, Patrick H., primary, and Hartley, John A., primary

Published
2023
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41. Data from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer

Author

Cho, Song, primary, Zammarchi, Francesca, primary, Williams, David G., primary, Havenith, Carin E.G., primary, Monks, Noel R., primary, Tyrer, Peter, primary, D'Hooge, Francois, primary, Fleming, Ryan, primary, Vashisht, Kapil, primary, Dimasi, Nazzareno, primary, Bertelli, Francois, primary, Corbett, Simon, primary, Adams, Lauren, primary, Reinert, Halla W., primary, Dissanayake, Sandamali, primary, Britten, Charles E., primary, King, Wanda, primary, Dacosta, Karma, primary, Tammali, Ravinder, primary, Schifferli, Kevin, primary, Strout, Patrick, primary, Korade, Martin, primary, Masson Hinrichs, Mary Jane, primary, Chivers, Simon, primary, Corey, Eva, primary, Liu, He, primary, Kim, Sae, primary, Bander, Neil H., primary, Howard, Philip W., primary, Hartley, John A., primary, Coats, Steve, primary, Tice, David A., primary, Herbst, Ronald, primary, and van Berkel, Patrick H., primary

Published
2023
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42. Supplemental Figure 3 from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Author

Flynn, Michael J., primary, Zammarchi, Francesca, primary, Tyrer, Peter C., primary, Akarca, Ayse U., primary, Janghra, Narinder, primary, Britten, Charles E., primary, Havenith, Carin E.G., primary, Levy, Jean-Noel, primary, Tiberghien, Arnaud, primary, Masterson, Luke A., primary, Barry, Conor, primary, D'Hooge, Francois, primary, Marafioti, Teresa, primary, Parren, Paul W.H.I., primary, Williams, David G., primary, Howard, Philip W., primary, van Berkel, Patrick H., primary, and Hartley, John A., primary

Published
2023
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43. Supplementary Methods from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer

Author

Cho, Song, primary, Zammarchi, Francesca, primary, Williams, David G., primary, Havenith, Carin E.G., primary, Monks, Noel R., primary, Tyrer, Peter, primary, D'Hooge, Francois, primary, Fleming, Ryan, primary, Vashisht, Kapil, primary, Dimasi, Nazzareno, primary, Bertelli, Francois, primary, Corbett, Simon, primary, Adams, Lauren, primary, Reinert, Halla W., primary, Dissanayake, Sandamali, primary, Britten, Charles E., primary, King, Wanda, primary, Dacosta, Karma, primary, Tammali, Ravinder, primary, Schifferli, Kevin, primary, Strout, Patrick, primary, Korade, Martin, primary, Masson Hinrichs, Mary Jane, primary, Chivers, Simon, primary, Corey, Eva, primary, Liu, He, primary, Kim, Sae, primary, Bander, Neil H., primary, Howard, Philip W., primary, Hartley, John A., primary, Coats, Steve, primary, Tice, David A., primary, Herbst, Ronald, primary, and van Berkel, Patrick H., primary

Published
2023
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44. Supplementary Tables S1 to S4 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer

Author

Cho, Song, primary, Zammarchi, Francesca, primary, Williams, David G., primary, Havenith, Carin E.G., primary, Monks, Noel R., primary, Tyrer, Peter, primary, D'Hooge, Francois, primary, Fleming, Ryan, primary, Vashisht, Kapil, primary, Dimasi, Nazzareno, primary, Bertelli, Francois, primary, Corbett, Simon, primary, Adams, Lauren, primary, Reinert, Halla W., primary, Dissanayake, Sandamali, primary, Britten, Charles E., primary, King, Wanda, primary, Dacosta, Karma, primary, Tammali, Ravinder, primary, Schifferli, Kevin, primary, Strout, Patrick, primary, Korade, Martin, primary, Masson Hinrichs, Mary Jane, primary, Chivers, Simon, primary, Corey, Eva, primary, Liu, He, primary, Kim, Sae, primary, Bander, Neil H., primary, Howard, Philip W., primary, Hartley, John A., primary, Coats, Steve, primary, Tice, David A., primary, Herbst, Ronald, primary, and van Berkel, Patrick H., primary

Published
2023
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45. Supplemental Figure 7 from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Author

Flynn, Michael J., primary, Zammarchi, Francesca, primary, Tyrer, Peter C., primary, Akarca, Ayse U., primary, Janghra, Narinder, primary, Britten, Charles E., primary, Havenith, Carin E.G., primary, Levy, Jean-Noel, primary, Tiberghien, Arnaud, primary, Masterson, Luke A., primary, Barry, Conor, primary, D'Hooge, Francois, primary, Marafioti, Teresa, primary, Parren, Paul W.H.I., primary, Williams, David G., primary, Howard, Philip W., primary, van Berkel, Patrick H., primary, and Hartley, John A., primary

Published
2023
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46. Supplemental Figure 2 from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Author

Flynn, Michael J., primary, Zammarchi, Francesca, primary, Tyrer, Peter C., primary, Akarca, Ayse U., primary, Janghra, Narinder, primary, Britten, Charles E., primary, Havenith, Carin E.G., primary, Levy, Jean-Noel, primary, Tiberghien, Arnaud, primary, Masterson, Luke A., primary, Barry, Conor, primary, D'Hooge, Francois, primary, Marafioti, Teresa, primary, Parren, Paul W.H.I., primary, Williams, David G., primary, Howard, Philip W., primary, van Berkel, Patrick H., primary, and Hartley, John A., primary

Published
2023
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47. Supplemental Figure 6 from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Author

Flynn, Michael J., primary, Zammarchi, Francesca, primary, Tyrer, Peter C., primary, Akarca, Ayse U., primary, Janghra, Narinder, primary, Britten, Charles E., primary, Havenith, Carin E.G., primary, Levy, Jean-Noel, primary, Tiberghien, Arnaud, primary, Masterson, Luke A., primary, Barry, Conor, primary, D'Hooge, Francois, primary, Marafioti, Teresa, primary, Parren, Paul W.H.I., primary, Williams, David G., primary, Howard, Philip W., primary, van Berkel, Patrick H., primary, and Hartley, John A., primary

Published
2023
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48. Supplemental Figure 4 from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Author

Flynn, Michael J., primary, Zammarchi, Francesca, primary, Tyrer, Peter C., primary, Akarca, Ayse U., primary, Janghra, Narinder, primary, Britten, Charles E., primary, Havenith, Carin E.G., primary, Levy, Jean-Noel, primary, Tiberghien, Arnaud, primary, Masterson, Luke A., primary, Barry, Conor, primary, D'Hooge, Francois, primary, Marafioti, Teresa, primary, Parren, Paul W.H.I., primary, Williams, David G., primary, Howard, Philip W., primary, van Berkel, Patrick H., primary, and Hartley, John A., primary

Published
2023
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49. Supplemental Figure 1 from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Author

Flynn, Michael J., primary, Zammarchi, Francesca, primary, Tyrer, Peter C., primary, Akarca, Ayse U., primary, Janghra, Narinder, primary, Britten, Charles E., primary, Havenith, Carin E.G., primary, Levy, Jean-Noel, primary, Tiberghien, Arnaud, primary, Masterson, Luke A., primary, Barry, Conor, primary, D'Hooge, Francois, primary, Marafioti, Teresa, primary, Parren, Paul W.H.I., primary, Williams, David G., primary, Howard, Philip W., primary, van Berkel, Patrick H., primary, and Hartley, John A., primary

Published
2023
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50. Supplemental methods and tables from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Author

Flynn, Michael J., primary, Zammarchi, Francesca, primary, Tyrer, Peter C., primary, Akarca, Ayse U., primary, Janghra, Narinder, primary, Britten, Charles E., primary, Havenith, Carin E.G., primary, Levy, Jean-Noel, primary, Tiberghien, Arnaud, primary, Masterson, Luke A., primary, Barry, Conor, primary, D'Hooge, Francois, primary, Marafioti, Teresa, primary, Parren, Paul W.H.I., primary, Williams, David G., primary, Howard, Philip W., primary, van Berkel, Patrick H., primary, and Hartley, John A., primary

Published
2023
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