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BackgroundHeterogenous central nervous system (CNS) neurologic manifestations of polyarteritis nodosa (PAN) are underrecognized. We review three cases of patients with PAN that illustrate a range of nervous system pathology, including the classical mononeuritis multiplex as well as uncommon brain and spinal cord vascular manifestations.Case presentationCase 1 presented with mononeuritis multiplex and characteristic skin findings. Case 2 presented with thunderclap headache and myelopathy due to spinal artery aneurysm rupture. Both patients experienced disease remission upon treatment. Case 3 presented with headache and bulbar symptoms due to partially thrombosed intracranial aneurysms, followed by systemic manifestations related to visceral aneurysms. She demonstrated clinical improvement with treatment, was lost to follow-up, then clinically deteriorated and entered hospice care.ConclusionsAlthough the peripheral manifestations of PAN are well-known, PAN association with CNS neurovascular disease is relatively underappreciated. Clinician awareness of the spectrum of neurologic disease is required to reduce diagnostic delay and promote prompt diagnosis and treatment with immunosuppressants.

The American eel (Anguilla rostrata) occupies a vast range in the West Atlantic Ocean and inflowing waters. Despite its presumed panmictic status, management of this species is geographically fragmented. There have been widespread calls for internationally coordinated efforts towards a range-wide stock assessment, but such an objective faces obstacles of a high degree of heterogeneity in major life history characteristics and the near-absence of such data in the northern, western, and southern parts of the species' range. This paper reviews novel and underutilized methods and data sources that may aid progress to an eventual range-wide assessment. Methods for obtaining information on distribution and abundance include mining of extant data and field surveys by glass bottom boat, electrofishing boat, net enclosures, environmental DNA (eDNA) and ocean larval tows. Analytic resources and tools include environmental databases, fetch as a covariate of abundance, accounting for the net effects of small ponds, GIS-oriented habitat modeling, glass eel-oriented population modeling, estimation of age structure from length structure, use of life history parameter clines to fill gaps in assessment input values, and life cycle modeling. eDNA is a cost-effective technique that has the potential to clarify American eel distribution, and possibly relative abundance, over the very large areas where data for this species are sparse. Most other techniques reviewed in this paper have substantial costs, which may constrain their use in the southern part of the American eel range where resources of aquatic science are often limited. [ABSTRACT FROM AUTHOR]