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Beamline B21 at the Diamond Light Source synchrotron in the UK is a small‐angle X‐ray scattering (SAXS) beamline that specializes in high‐throughput measurements via automated sample delivery systems. A system has been developed whereby a sample can be illuminated by a focused beam of light coincident with the X‐ray beam. The system is compatible with the highly automated sample delivery system at the beamline and allows a beamline user to select a light source from a broad range of wavelengths across the UV and visible spectrum and to control the timing and duration of the light pulse with respect to the X‐ray exposure of the SAXS measurement. The intensity of the light source has been characterized across the wavelength range enabling experiments where a quantitative measure of dose is important. Finally, the utility of the system is demonstrated via measurement of several light‐responsive samples. [ABSTRACT FROM AUTHOR]

This paper presents the results of a project aimed at the development of reliable corona-suppression systems for high voltage rotating machines. These systems are based on both conducting and semi-conducting dry and B-stage tapes as well as paints of different resistivity. Three groups of anti-corona systems were developed; namely, paint (on the slot portion)--paint (on the slot exit) system, paint (on the slot portion)--tape (on the slot exit) system, and tape (on the slot portion)--tape (on the slot exit) system. Sample results of standard evaluation and acceptance tests are presented. The accelerated life-aging test was run on test coil samples at the National Electric Coil HV testing facility. A numerical 2-dimensional finite difference model for the electric potential and field analysis along the end-turn zone was developed and the model results are used as guidelines through the design process of the grading system. Laboratory test results on randomly selected sample coils were confirmed by an independent testing facility. The proposed corona-suppression systems were applied on thousands of production coils.

Examines learning style characteristics of developmental and nondevelopmental junior college students. Finds significant differences between developmental and nondevelopmental students including field dependence, learning in the afternoon, sound present during learning, and motivation. Finds that field dependence-independence was the single best discriminator between developmental and nondevelopmental students. (RS)

A beginning teacher's audiovisual portfolio would give the prospective employer a clear idea of the applicant's actual teaching style and ability. (Author/MLF)

Background: Misfolded, toxic aggregates of proteins capable of prion‐like propagation from cell to cell have been implicated in the pathogenesis of neurodegenerative disorders. For example, toxic oligomers of amyloid‐beta (Abeta) as well as oligomers and small soluble fibrils of tau and alpha‐synuclein (Asyn) have been reported to contribute to neuronal damage and progression of Alzheimer's disease as well as various tauopathies (e.g. FTLD, progressive supranuclear palsy) and synucleinopathies (e.g. Parkinson's, Lewy body dementia, multiple system atrophy). Misfolding of these proteins into toxic forms leads to the exposure of conformational epitopes not normally present on the healthy form of the protein. In these studies, we sought to determine whether these small misfolded regions may not only represent a target for therapeutic antibodies but also directly contribute to the pathogenic seeding activity of misfolded proteins. Method: Computational modeling was used to predict conformational epitopes likely to become solvent‐exposed on toxic aggregates of Abeta, tau and Asyn but not on non‐toxic forms of the proteins. Antibodies raised against cyclic peptide scaffolds replicating these conformational epitopes were tested for binding to various forms of each protein by surface plasmon resonance (SPR) to confirm restricted expression on toxic species. The seeding activity of the conformational peptide epitope scaffolds was tested in a thioflavin T (ThT) propagation assay by measuring the fibrillogenic aggregation of protein monomers with and without the addition of peptide epitope over time. Result: Antibodies raised against predicted conformational epitopes of misfolded Abeta, Asyn and tau showed selective recognition of toxic species by SPR indicating that the epitopes are not exposed on normal, healthy forms of these proteins. The conformational cyclic peptide scaffolds, but not the linear versions of the same peptides, showed seeding activity in ThT propagation assays for all 3 proteins. Conclusion: Small misfolded regions (conformational epitopes) exposed on misfolded toxic proteins can, on their own, replicate the seeding activity of the full‐length protein suggesting that they contribute to its prion‐like pathogenicity. These results also indicate that these conformational epitopes represent a biologically relevant target for therapeutic antibodies. [ABSTRACT FROM AUTHOR]

Describes the development of an audiovisual portfolio, consisting of a student teaching notebook, slide narrative presentation, audiotapes, and a videotape-- valuable for prospective teachers in job interviews. (CMV)

The audiovisual portfolio helps beginning teachers demonstrate qualities that might not show up in a traditional job interview. Included in the portfolio are a student teaching notebook, a slide narrative presentation, audiocassette tapes, and a videotape of lessons taught during student teaching. (Author)

The use of audiovisual material such as slide narrations and audio-videotape recording is of assistance to beginning teachers seeking employment. (LH)