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5,884 results on '"Williams, Gareth"'

2. Ch08

Author

Williams, Gareth R., Raimi-Abraham, Bahijja T., and Luo, C. J.

Published
2018

3. Backcover

Author

Williams, Gareth R., Raimi-Abraham, Bahijja T., and Luo, C. J.

Published
2018

6. Chapter 2 Viking camps: A historiographical overview

Author

Williams, Gareth

Subjects
Viking Camps, Ireland, England, Sweden, Frankia, Iberia, winter camps, Viking military camps, Viking Encampment, viking economy, archaeology, Viking archaeology, history, Viking Studies., bic Book Industry Communication::H Humanities::HD Archaeology
Abstract

This paper presents a broad-reaching overview of the study of Viking camps, and how this has developed since the 1970s. The paper considers how the camps have been interpreted in the past, summarises the evidence of the individual sites which have been investigated, and draws out a number of key themes which have emerged in recent research on the subject, both in this volume and elsewhere.

Published
2023
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13. Cover

Author

Santiago, Silviano, Gazzola, Ana Lucia, Burns, Tom, Williams, Gareth, and Jameson, Fredric

Published
2002

14. Index

Author

Santiago, Silviano, Gazzola, Ana Lucia, Burns, Tom, Williams, Gareth, and Jameson, Fredric

Published
2002

17. 10. The Postmodern Narrator

Author

Santiago, Silviano, Gazzola, Ana Lucia, Burns, Tom, Williams, Gareth, and Jameson, Fredric

Published
2002

18. Title, Copyright

Author

Santiago, Silviano, Gazzola, Ana Lucia, Burns, Tom, Williams, Gareth, and Jameson, Fredric

Published
2002

19. Notes

Author

Santiago, Silviano, Gazzola, Ana Lucia, Burns, Tom, Williams, Gareth, and Jameson, Fredric

Published
2002

29. Index

Author

Williams, Gareth

Published
2002

32. Notes

Author

Williams, Gareth

Published
2002

33. Cover

Author

Williams, Gareth

Published
2002

34. Works Cited

Author

Williams, Gareth

Published
2002

39. Perhaps

Author

Williams, Gareth

Published
2002

46. RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles

Author

Longo, Michael A, Roy, Sunetra, Chen, Yue, Tomaszowski, Karl-Heinz, Arvai, Andrew S, Pepper, Jordan T, Boisvert, Rebecca A, Kunnimalaiyaan, Selvi, Keshvani, Caezanne, Schild, David, Bacolla, Albino, Williams, Gareth J, Tainer, John A, and Schlacher, Katharina

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Physical Sciences, Oncology and Carcinogenesis, Genetics, Breast Cancer, Cancer, Ovarian Cancer, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Male, Humans, Prostatic Neoplasms, Rad51 Recombinase, Mutation, DNA Replication, Adenosine Triphosphate, DNA-Binding Proteins
Abstract

RAD51C is an enigmatic predisposition gene for breast, ovarian, and prostate cancer. Currently, missing structural and related functional understanding limits patient mutation interpretation to homology-directed repair (HDR) function analysis. Here we report the RAD51C-XRCC3 (CX3) X-ray co-crystal structure with bound ATP analog and define separable RAD51C replication stability roles informed by its three-dimensional structure, assembly, and unappreciated polymerization motif. Mapping of cancer patient mutations as a functional guide confirms ATP-binding matching RAD51 recombinase, yet highlights distinct CX3 interfaces. Analyses of CRISPR/Cas9-edited human cells with RAD51C mutations combined with single-molecule, single-cell and biophysics measurements uncover discrete CX3 regions for DNA replication fork protection, restart and reversal, accomplished by separable functions in DNA binding and implied 5' RAD51 filament capping. Collective findings establish CX3 as a cancer-relevant replication stress response complex, show how HDR-proficient variants could contribute to tumor development, and identify regions to aid functional testing and classification of cancer mutations.

Published
2023

50. Advanced Formulation Approaches for Emerging Therapeutic Technologies

Author

Allahham, Nour, Colic, Ines, Rayner, Melissa L. D., Gurnani, Pratik, Phillips, James B., Rahim, Ahad A., Williams, Gareth R., Michel, Martin C., Editor-in-Chief, Barrett, James E., Editorial Board Member, Centurión, David, Editorial Board Member, Flockerzi, Veit, Editorial Board Member, Meier, Kathryn Elaine, Editorial Board Member, Page, Clive P., Editorial Board Member, Seifert, Roland, Editorial Board Member, Wang, KeWei, Editorial Board Member, Schäfer-Korting, Monika, editor, and Schubert, Ulrich S., editor

Published
2024
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