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2. Time to Treatment in Pediatric Patients with Repeated Episodes of Status Epilepticus

Author

Gettings, Jennifer V., primary, Fernández, Iván Sánchez, additional, Anderson, Anne, additional, Brenton, J. Nicholas, additional, Can, Afra, additional, Clark, Justice, additional, Moeller, Raquel Farias, additional, Goodkin, Howard P., additional, Lai, Yi-Chen, additional, Mikati, Mohamad A., additional, Morgan, Lindsey A., additional, Novotny, Edward, additional, Ostendorf, Adam P., additional, Piantino, Juan, additional, Riviello, James J., additional, Sannagowdara, Kumar, additional, Tasker, Robert C., additional, Tchapyjnikov, Dmitry, additional, Wainwright, Mark S., additional, Wilfong, Angus, additional, Williams, Korwyn, additional, Zhang, Bo, additional, Loddenkemper, Tobias, additional, and Gaínza-Lein, Marina, additional

Published
2024
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3. The onset of pediatric refractory status epilepticus is not distributed uniformly during the day

Author

Sánchez Fernández, Iván, Gaínza-Lein, Marina, Abend, Nicholas S., Amengual-Gual, Marta, Anderson, Anne, Arya, Ravindra, Brenton, J. Nicholas, Carpenter, Jessica L., Chapman, Kevin E., Clark, Justice, Farias-Moeller, Raquel, Davis Gaillard, William, Glauser, Tracy A., Goldstein, Joshua, Goodkin, Howard P., Guerriero, Réjean M., Hecox, Kurt, Jackson, Michele, Kapur, Kush, Kelley, Sarah A., Kossoff, Eric H.W., Lai, Yi-Chen, McDonough, Tiffani L., Mikati, Mohamad A., Morgan, Lindsey A., Novotny, Edward J., Ostendorf, Adam P., Payne, Eric T., Peariso, Katrina, Piantino, Juan, Riviello, James J., Jr., Sannagowdara, Kumar, Stafstrom, Carl E., Tasker, Robert C., Tchapyjnikov, Dmitry, Topjian, Alexis A., Vasquez, Alejandra, Wainwright, Mark S., Wilfong, Angus, Williams, Korwyn, and Loddenkemper, Tobias

Published
2019
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4. Super-Refractory Status Epilepticus in Children: A Retrospective Cohort Study

Author

Vasquez, Alejandra, Farias-Moeller, Raquel, Sánchez-Fernández, Iván, Abend, Nicholas S., Amengual-Gual, Marta, Anderson, Anne, Arya, Ravindra, Brenton, James N., Carpenter, Jessica L., Chapman, Kevin, Clark, Justice, Gaillard, William D., Glauser, Tracy, Goldstein, Joshua L., Goodkin, Howard P., Guerriero, Rejean M., Lai, Yi-Chen, McDonough, Tiffani L., Mikati, Mohamad A., Morgan, Lindsey A., Novotny, Edward J., Ostendorf, Adam P., Payne, Eric T., Peariso, Katrina, Piantino, Juan, Riviello, James J., Sands, Tristan T., Sannagowdara, Kumar, Tasker, Robert C., Tchapyjnikov, Dmitry, Topjian, Alexis, Wainwright, Mark S., Wilfong, Angus, Williams, Korwyn, and Loddenkemper, Tobias

Published
2021
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5. Pediatric status epilepticus management by Emergency Medical Services (the pSERG cohort)

Author

Amengual-Gual, Marta, primary, Sánchez Fernández, Iván, additional, Vasquez, Alejandra, additional, Abend, Nicholas S., additional, Anderson, Anne, additional, Arya, Ravindra, additional, Barcia Aguilar, Cristina, additional, Brenton, J. Nicholas, additional, Carpenter, Jessica L., additional, Chapman, Kevin E., additional, Clark, Justice, additional, Farias-Moeller, Raquel, additional, Gaillard, William D., additional, Glauser, Tracy A., additional, Goldstein, Joshua L., additional, Goodkin, Howard P., additional, Lai, Yi-Chen, additional, Mikati, Mohamad A., additional, Morgan, Lindsey A., additional, Novotny, Edward J., additional, Ostendorf, Adam P., additional, Payne, Eric T., additional, Peariso, Katrina, additional, Piantino, Juan, additional, Reece, Latania, additional, Riviello, James J., additional, Sannagowdara, Kumar, additional, Sheehan, Theodore, additional, Tasker, Robert C., additional, Tchapyjnikov, Dmitry, additional, Topjian, Alexis A., additional, Wainwright, Mark S., additional, Wilfong, Angus, additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2023
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7. First-line medication dosing in pediatric refractory status epilepticus

Author

Vasquez, Alejandra, Gaínza-Lein, Marina, Abend, Nicholas S., Amengual-Gual, Marta, Anderson, Anne, Arya, Ravindra, Brenton, J. Nicholas, Carpenter, Jessica L., Chapman, Kevin, Clark, Justice, Farias-Moeller, Raquel, Gaillard, William D., Glauser, Tracy, Goldstein, Joshua L., Goodkin, Howard P., Guerriero, Rejean M., Kapur, Kush, Lai, Yi-Chen, McDonough, Tiffani L., Mikati, Mohamad A., Morgan, Lindsey A., Novotny, Edward J., Ostendorf, Adam P., Payne, Eric T., Peariso, Katrina, Piantino, Juan, Riviello, James J., Sannagowdara, Kumar, Tasker, Robert C., Tchapyjnikov, Dmitry, Topjian, Alexis, Wainwright, Mark S., Wilfong, Angus, Williams, Korwyn, Loddenkemper, Tobias, Bansal, Seema, Kelley, Sarah, Stafstrom, Carl, Kossoff, Eric, Habela, Christa, Lewis, Dalila, Stanfield, Tony, Sculier, Claudine, Aguilar, Cristina Barcia, Sansevere, Arnold, Sacco, Melissa, Duncan, Abby, McCoy, Jordan, DaSilva-Chiodo, Kathryn, Faist, Robert, Santel, Daniel, LaFay, Victor, Clark, Peggy, Borror, Sarah, Debs, Andrea, Clohessy, Caitlin, Weber, Amanda, Yuliati, Asri, Luat, Aimee, Singh, Azara, Helseth, Ashley, Turner, David, Fernandes, Cecilia, Tran, Linh, McLean, Melissa, Nayak, Anuranjita, Riviello, James J, Jr, Hecox, Kurt, Nallamothu, Rupa, Rehborg, Rebecca, Goldstein, David, Heinzen Cox, Erin, Malone, Colin, Thornburg, Olivia, Grinspan, Zachary, Basma, Natasha, Appavu, Brian, Burrows, Brian, Dyar, Beata, Mishler, Laura, Lee-Eng, Jacqueline, Streb, Madison, Hahn, Cecil, Lalgudi Ganesan, Saptharishi (Rishi), Huh, Linda, and Martic, Nela

Published
2020
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8. Electroencephalographic Reporting for Refractory Status Epilepticus

Author

Sansevere, Arnold J., Arya, Ravindra, Sánchez Fernández, Iván, Gaillard, William D., Tasker, Robert C., Lai, Yi-Chen, Anderson, Anne E., Tchapyjnikov, Dmitry, Chapman, Kevin E., Brenton, J. Nicholas, Carpenter, Jessica L., Gaínza-Lein, Marina, Goldstein, Joshua L., Goodkin, Howard P., Jackson, Michele C., Kapur, Kush, Mikati, Mohamad A., Peariso, Katrina, Glauser, Tracy A., Topjian, Alexis A., Wainwright, Mark, Wilfong, Angus A., Williams, Korwyn L., Loddenkemper, Tobias, and Abend, Nicholas S.

Published
2019
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9. Development and validation of a seizure prediction model in critically ill children

Author

Yang, Amy, Arndt, Daniel H., Berg, Robert A., Carpenter, Jessica L., Chapman, Kevin E., Dlugos, Dennis J., Gallentine, William B., Giza, Christopher C., Goldstein, Joshua L., Hahn, Cecil D., Lerner, Jason T., Loddenkemper, Tobias, Matsumoto, Joyce H., Nash, Kendall B., Payne, Eric T., Sánchez Fernández, Iván, Shults, Justine, Topjian, Alexis A., Williams, Korwyn, Wusthoff, Courtney J., and Abend, Nicholas S.

Published
2015
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10. Gaps and opportunities in refractory status epilepticus research in children: A multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG)

Author

Sánchez Fernández, Iván, Abend, Nicholas S., Agadi, Satish, An, Sookee, Arya, Ravindra, Carpenter, Jessica L., Chapman, Kevin E., Gaillard, William D., Glauser, Tracy A., Goldstein, David B., Goldstein, Joshua L., Goodkin, Howard P., Hahn, Cecil D., Heinzen, Erin L., Mikati, Mohamad A., Peariso, Katrina, Pestian, John P., Ream, Margie, Riviello, James J., Jr., Tasker, Robert C., Williams, Korwyn, and Loddenkemper, Tobias

Published
2014
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12. Tackling Quality—It's Never a Level Playing Field

Author

Cabaniss, Brian, Williams, Korwyn, Ward, Meghan, Cremeen, Desiree, and Nair, Kavita

Subjects
Commentary, Neurology (clinical), health care economics and organizations
Abstract

The American Academy of Neurology (AAN) has recently proposed 3 outcome metrics crafted to be both broadly applicable across neurologic diseases and to function as potential tools to facilitate quality improvement. These measures should be of interest to physicians and payers due to the increasing linkage of reimbursement to quality care. However, the use of quality measures cannot exist in a vacuum as external factors outside of physician control can negatively affect these metrics. The original Centers for Medicare and Medicaid (CMS) value-based programs illustrate the necessity for iterative review and revision of outcome metrics to allow for risk adjustment to avoid unjust penalties. Accordingly, at this time, the Neurology Outcome Measurement Set is not suitable for inclusion in a quality payment program.

Published
2022

13. Refractory status epilepticus in children with and without prior epilepsy or status epilepticus

Author

Sánchez Fernández, Iván, Jackson, Michele C., Abend, Nicholas S., Arya, Ravindra, Brenton, James N., Carpenter, Jessica L., Chapman, Kevin E., Gaillard, William D., Gaínza-Lein, Marina, Glauser, Tracy A., Goldstein, Joshua L., Goodkin, Howard P., Helseth, Ashley, Kapur, Kush, McDonough, Tiffani L., Mikati, Mohamad A., Peariso, Katrina, Riviello, James, Jr, Tasker, Robert C., Topjian, Alexis A., Wainwright, Mark S., Wilfong, Angus, Williams, Korwyn, and Loddenkemper, Tobias

Published
2017
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14. Spatiotemporal dynamics of interictal spikes

Author

Krishnan, Balu, Vlachos, Ioannis, Faith, Aaron, Mullane, Stephen, Williams, Korwyn, and Iasemidis, Leonidas

Subjects
Seizures (Medicine) -- Physiological aspects, Action potentials (Electrophysiology) -- Models, Epilepsy -- Physiological aspects, Science and technology
Abstract

The relationship of epileptic spikes to seizures has been a matter of debate with researchers reporting higher or lower spike rates before and after seizures. To elucidate a possible role of spikes in ictogenesis (seizure generation) we developed a mathematical framework to investigate the spatiotemporal dynamics of spikes in the epileptic brain. Long-term (5-10 days) intracranial electroencephalograms (iEEGs) from 2 patients with temporal lobe epilepsy who underwent presurgical evaluation for localization of candidate epileptic foci were used in the study. First, spikes were detected using an in-house spike detection algorithm. To characterize the spatiotemporal changes in spikes a novel spatial synchronization measure (SSM) of spikes was developed. Application of SSM to iEEG revealed monotonically increasing long-term preictal synchronization between spike trains at brain sites that included the epileptogenic zone. The presence of preictal synchronization of spikes hours to minutes prior to the onset of seizures indicates a possible predictive value of spike synchronization for seizure occurrence. Furthermore, across seizures and patients, we observed that desynchronization of spikes at critical brain sites mostly occurred in postictal epochs. We characterized these observed changes between preictal and postical spike synchronization by a measure of resetting based on the fraction of pairs that synchronize preictally and desynchronize postictally. On the basis of this resetting measure, we showed that resetting of spike synchronization occurs more commonly at seizures than interictally (p Keywords: Epilepsy, Spikes, Seizures, Spatiotemporal Analysis, Ictogenesis, INTRODUCTION Epilepsy is a widely prevalent neurological disorder affecting around 50 million people worldwide and has been classified as the third most common neurological disorder next to stroke and Alzheimer's. [...]

Published
2015

15. Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children

Author

Peariso, Katrina, Arya, Ravindra, Glauser, Tracy, Abend, Nicholas S., Barcia Aguilar, Cristina, Amengual-Gual, Marta, Anderson, Anne, Appavu, Brian L., Brenton, J. Nicholas, Carpenter, Jessica, Chapman, Kevin E., Clark, Justice, Gaillard, William D., Gaínza-Lein, Marina, Goldstein, Joshua, Goodkin, Howard, Grinspan, Zachary, Guerriero, Rejean M., Horn, Paul S., Huh, Linda, Kahoud, Robert, Kelley, Sarah A., Kossoff, Eric H., Kapur, Kush, Lai, Yi-Chen, Marquis, B. Oyinkan, McDonough, Tiffani, Mikati, Mohamad A., Morgan, Lindsey, Novotny, Edward, Ostendorf, Adam P., Payne, Eric T., Piantino, Juan, Riviello, James, Sands, Tristan, Stafstrom, Carl E., Tasker, Robert C., Tchapyjnikov, Dmitry, Vasquez, Alejandra, Wainwright, Mark S., Wilfong, Angus, Williams, Korwyn, Loddenkemper, Tobias, Bansal, Seema, Habela, Christa, Lewis, Dalila, Sculier, Claudine, Sacco, Melissa, Santel, Daniel, Weber, Amanda, Yuliati, Asri, Singh, Azara, Heath, Ashley, Turner, David, Fernandes, Cecilia, Tran, Linh, Farias-Moeller, Raquel, Hecox, Kurt, Sannagowdara, Kumar, Goldstein, David, Cox, Erin Heinzen, Malone, Colin, Topjian, Alexis, Hahn, Cecil, Ganesan, Saptharishi (Rishi) Lalgudi, Weinstein, Steven, Dean, Nathan, Shellhaas, Renee, Benedetti, Guilia, Smith, Garnett, Selioutski, Olga, Hughes, Inna, and Seltzer, Lurie

Published
2023
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18. Time to Treatment in Pediatric Convulsive Refractory Status Epilepticus: The Weekend Effect

Author

Barcia Aguilar, Cristina, primary, Amengual-Gual, Marta, additional, Sánchez Fernández, Iván, additional, Abend, Nicholas S., additional, Anderson, Anne, additional, Appavu, Brian, additional, Arya, Ravindra, additional, Brenton, J. Nicholas, additional, Carpenter, Jessica L., additional, Chapman, Kevin E., additional, Clark, Justice, additional, Farias-Moeller, Raquel, additional, Gaillard, William D., additional, Gaínza-Lein, Marina, additional, Glauser, Tracy, additional, Goldstein, Joshua L., additional, Goodkin, Howard P., additional, Guerriero, Rejean M., additional, Huh, Linda, additional, Lai, Yi-Chen, additional, McDonough, Tiffani L., additional, Mikati, Mohamad A., additional, Morgan, Lyndsey A., additional, Novotny, Edward J., additional, Ostendorf, Adam, additional, Payne, Eric T., additional, Peariso, Katrina, additional, Piantino, Juan, additional, Riviello, James, additional, Sannagowdara, Kumar, additional, Sheehan, Theodore, additional, Sands, Tristan T., additional, Tasker, Robert C., additional, Tchapyjnikov, Dmitry, additional, Topjian, Alexis A., additional, Vasquez, Alejandra, additional, Wainwright, Mark S., additional, Wilfong, Angus A., additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2021
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19. Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort)

Author

Sculier, Claudine, Barcia Aguilar, Cristina, Gaspard, Nicolas, Gaínza-Lein, Marina, Sánchez Fernández, Iván, Amengual-Gual, Marta, Anderson, Anne, Arya, Ravindra, Burrows, Brian B.T., Brenton, James Nicholas, Carpenter, Jessica J.L., Chapman, Kevin K.E., Clark, Justice, Gaillard, William Davis Avis W.D., Glauser, Tracy, Goldstein, Joshua J.L., Goodkin, Howard H.P., Gorman, Mark, Lai, Yi Chen, McDonough, Tiffani T.L., Mikati, Mohamad A, Nayak, Anuranjita, Peariso, Katrina, Riviello, James, Rusie, Allison, Sperberg, Katherine, Stredny, Coral C.M., Tasker, Robert, Tchapyjnikov, Dmitry, Vasquez, Alejandra, Wainwright, Mark M.S., Wilfong, Angus A.A., Williams, Korwyn, Loddenkemper, Tobias, Sculier, Claudine, Barcia Aguilar, Cristina, Gaspard, Nicolas, Gaínza-Lein, Marina, Sánchez Fernández, Iván, Amengual-Gual, Marta, Anderson, Anne, Arya, Ravindra, Burrows, Brian B.T., Brenton, James Nicholas, Carpenter, Jessica J.L., Chapman, Kevin K.E., Clark, Justice, Gaillard, William Davis Avis W.D., Glauser, Tracy, Goldstein, Joshua J.L., Goodkin, Howard H.P., Gorman, Mark, Lai, Yi Chen, McDonough, Tiffani T.L., Mikati, Mohamad A, Nayak, Anuranjita, Peariso, Katrina, Riviello, James, Rusie, Allison, Sperberg, Katherine, Stredny, Coral C.M., Tasker, Robert, Tchapyjnikov, Dmitry, Vasquez, Alejandra, Wainwright, Mark M.S., Wilfong, Angus A.A., Williams, Korwyn, and Loddenkemper, Tobias

Abstract

Objective: We aimed to characterize the clinical profile and outcomes of new onset refractory status epilepticus (NORSE) in children, and investigated the relationship between fever onset and status epilepticus (SE). Methods: Patients with refractory SE (RSE) between June 1, 2011 and October 1, 2016 were prospectively enrolled in the pSERG (Pediatric Status Epilepticus Research Group) cohort. Cases meeting the definition of NORSE were classified as "NORSE of known etiology" or "NORSE of unknown etiology." Subgroup analysis of NORSE of unknown etiology was completed based on the presence and time of fever occurrence relative to RSE onset: fever at onset (≤24 h), previous fever (2 weeks–24 h), and without fever. Results: Of 279 patients with RSE, 46 patients met the criteria for NORSE. The median age was 2.4 years, and 25 (54%) were female. Forty (87%) patients had NORSE of unknown etiology. Nineteen (48%) presented with fever at SE onset, 16 (40%) had a previous fever, and five (12%) had no fever. The patients with preceding fever had more prolonged SE and worse outcomes, and 25% recovered baseline neurological function. The patients with fever at onset were younger and had shorter SE episodes, and 89% recovered baseline function. Significance: Among pediatric patients with RSE, 16% met diagnostic criteria for NORSE, including the subcategory of febrile infection-related epilepsy syndrome (FIRES). Pediatric NORSE cases may also overlap with refractory febrile SE (FSE). FIRES occurs more frequently in older children, the course is usually prolonged, and outcomes are worse, as compared to refractory FSE. Fever occurring more than 24 h before the onset of seizures differentiates a subgroup of NORSE patients with distinctive clinical characteristics and worse outcomes., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

20. Electroencephalography monitoring in critically ill children: Current practice and implications for future study design

Author

Sánchez, Sarah M., Arndt, Daniel H., Carpenter, Jessica L., Chapman, Kevin E., Cornett, Karen M., Dlugos, Dennis J., Gallentine, William B., Giza, Christopher C., Goldstein, Joshua L., Hahn, Cecil D., Lerner, Jason T., Loddenkemper, Tobias, Matsumoto, Joyce H., McBain, Kristin, Nash, Kendall B., Payne, Eric, Fernández, Iván Sánchez, Shults, Justine, Williams, Korwyn, Yang, Amy, and Abend, Nicholas S.

Published
2013
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24. Resting-state functional MRI connectivity impact on epilepsy surgery plan and surgical candidacy: prospective clinical work

Author

Boerwinkle, Varina L., primary, Mirea, Lucia, additional, Gaillard, William D., additional, Sussman, Bethany L., additional, Larocque, Diana, additional, Bonnell, Alexandra, additional, Ronecker, Jennifer S., additional, Troester, Matthew M., additional, Kerrigan, John F., additional, Foldes, Stephen T., additional, Appavu, Brian, additional, Jarrar, Randa, additional, Williams, Korwyn, additional, Wilfong, Angus A., additional, and Adelson, P. David, additional

Published
2020
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25. Electrographic Seizures after Convulsive Status Epilepticus in Children and Young Adults: A Retrospective Multicenter Study

Author

Fernández, Iván Sánchez, Abend, Nicholas S., Arndt, Daniel H., Carpenter, Jessica L., Chapman, Kevin E., Cornett, Karen M., Dlugos, Dennis J., Gallentine, William B., Giza, Christopher C., Goldstein, Joshua L., Hahn, Cecil D., Lerner, Jason T., Matsumoto, Joyce H., McBain, Kristin, Nash, Kendall B., Payne, Eric, Sánchez, Sarah M., Williams, Korwyn, and Loddenkemper, Tobias

Published
2014
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27. Network‐targeted approach and postoperative resting‐state functional magnetic resonance imaging are associated with seizure outcome

Author

Boerwinkle, Varina L., primary, Cediel, Emilio G., additional, Mirea, Lucia, additional, Williams, Korwyn, additional, Kerrigan, John F., additional, Lam, Sandi, additional, Raskin, Jeffrey S., additional, Desai, Virendra R., additional, Wilfong, Angus A., additional, Adelson, P. David, additional, and Curry, Daniel J., additional

Published
2019
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28. Subcentimeter epilepsy surgery targets by resting state functional magnetic resonance imaging can improve outcomes in hypothalamic hamartoma

Author

Boerwinkle, Varina L., primary, Foldes, Stephen T., additional, Torrisi, Salvatore J., additional, Temkit, Hamy, additional, Gaillard, William D., additional, Kerrigan, John F., additional, Desai, Virendra R., additional, Raskin, Jeffrey S., additional, Vedantam, Aditya, additional, Jarrar, Randa, additional, Williams, Korwyn, additional, Lam, Sandi, additional, Ranjan, Manish, additional, Broderson, Janna S., additional, Adelson, David, additional, Wilfong, Angus A., additional, and Curry, Daniel J., additional

Published
2018
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29. Platform Session – Electroencephalography/Epilepsy: Clinical characteristics and outcomes of pediatric super refractory status epilepticus

Author

Vasquez, Alejandra, primary, Farias-Moeller, Raquel, additional, Fernández, Iván Sánchez, additional, Abend, Nicholas S., additional, Anderson, Anne, additional, Nicholas Brenton, J., additional, Clark, Justice, additional, Glauser, Tracy, additional, Goldstein, Joshua, additional, Goodkin, Howard P., additional, Lai, Yi-Chen, additional, McDonough, Tiffani L., additional, Mikati, Mohamad A., additional, Peariso, Katrina, additional, Arya, Ravindra, additional, Riviello, James, additional, Tchapyjnikov, Dmitry, additional, Tasker, Robert C., additional, Topjian, Alexis A., additional, Wainwright, Mark S., additional, Wilfong, Angus, additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2018
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30. Children with new-onset refractory status epilepticus from a multicenter US registry

Author

Sculier, Claudine, primary, Gaínza-Lein, Marina, additional, Gaspard, Nicolas, additional, Fernández, Iván Sánchez, additional, Abend, Nicholas S., additional, Anderson, Ann, additional, Arya, Ravindra, additional, Brenton, J. Nicholas, additional, Carpenter, Jessica L., additional, Chapman, Kevin E., additional, Gaillard, William, additional, Glauser, Tracy A., additional, Goldstein, Joshua L., additional, Goodkin, Howard P., additional, Mikati, Mohamad A., additional, Nayak, Anuranjita, additional, Peariso, Katrina, additional, Riviello, James J., additional, Tasker, Robert C., additional, Tchapyjnikov, Dmitry, additional, Topjian, Alexis A., additional, Wainwright, Mark S., additional, Wilfong, Angus, additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2017
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31. Refractory status epilepticus in children with and without prior epilepsy or status epilepticus

Author

Sánchez Fernández, Iván, primary, Jackson, Michele C., additional, Abend, Nicholas S., additional, Arya, Ravindra, additional, Brenton, James N., additional, Carpenter, Jessica L., additional, Chapman, Kevin E., additional, Gaillard, William D., additional, Gaínza-Lein, Marina, additional, Glauser, Tracy A., additional, Goldstein, Joshua L., additional, Goodkin, Howard P., additional, Helseth, Ashley, additional, Kapur, Kush, additional, McDonough, Tiffani L., additional, Mikati, Mohamad A., additional, Peariso, Katrina, additional, Riviello, James, additional, Tasker, Robert C., additional, Topjian, Alexis A., additional, Wainwright, Mark S., additional, Wilfong, Angus, additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2016
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32. Outcomes among patients with infantile spasms treated with hormonal therapy and adjuvant topiramate versushormonal therapy alone

Author

Fox, Jordana R., Guido‐Estrada, Natalie, Williams, Korwyn, and Jarrar, Randa

Abstract

Aims: Hormonal therapy is the first‐line treatment for infantile spasms and is sometimes used in combination with topiramate for better seizure control and potentially improved developmental outcomes. Methods: Retrospective review of pediatric patients with infantile spasms, with data compiled on patient sex, age at onset, etiology, electroencephalographic and imaging findings, topiramate use, spasm resolution (at one, six, and 12 months), and developmental outcome (at 12 months). Results: Of 105 patients screened, 55 (28 female) met inclusion criteria (28 [51%] had spasms with known etiology and 27 [49%] had spasms with unknown etiology). Forty‐six patients were followed for 12 months or longer to determine seizure outcome; a 12‐month developmental assessment was documented for 49 patients. Thirty‐seven patients (67%) received combination therapy; 18 (33%) received hormonal therapy alone. Resolution of spasms was comparable among treatment groups, with no difference relative to spasm etiology (p>0.18 for all). No difference was found in developmental outcomes with and without adjunct topiramate (p=0.38). Conclusions: Combination therapy was the most common treatment at our institution. However, combination therapy was not found to be beneficial for the treatment of spasms or developmental outcomes when compared to hormonal therapy alone.

Published
2020
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33. Refractory Status Epilepticus in Children

Author

Tasker, Robert C., primary, Goodkin, Howard P., additional, Sánchez Fernández, Iván, additional, Chapman, Kevin E., additional, Abend, Nicholas S., additional, Arya, Ravindra, additional, Brenton, James N., additional, Carpenter, Jessica L., additional, Gaillard, William D., additional, Glauser, Tracy A., additional, Goldstein, Joshua, additional, Helseth, Ashley R., additional, Jackson, Michele C., additional, Kapur, Kush, additional, Mikati, Mohamad A., additional, Peariso, Katrina, additional, Wainwright, Mark S., additional, Wilfong, Angus A., additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2016
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34. Status Epilepticus in Children: Relationship between Pre-Hospital Treatment and Outcome (P4.211)

Author

Gaínza Lein, Marina, primary, Sánchez Fernández, Iván, additional, Jackson, Michele, additional, Abend, Nicholas, additional, Arya, Ravindra, additional, Brenton, J., additional, Carpenter, Jessica, additional, Chapman, Kevin, additional, Gaillard, William, additional, Glauser, Tracy, additional, Goldstein, Joshua, additional, Goodkin, Howard, additional, Helseth, Ashley, additional, Kapur, Kush, additional, Mikati, Mohamad, additional, Peariso, Katrina, additional, Tasker, Robert, additional, Topjian, Alexis, additional, Wainwright, Mark, additional, Wilfong, Angus, additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2016
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36. Where and How Are the Initial Antiepileptic Drugs Administered to Children Who Develop Refractory Status Epilepticus? Results from the Pediatric Status Epilepticus Research Group (pSERG) (P3.006)

Author

Sanchez Fernandez, Ivan, primary, Abend, Nicholas, additional, Agadi, Satish, additional, Arya, Ravindra, additional, Basu, Rajit, additional, Carpenter, Jessica, additional, Chapman, Kevin, additional, Dean, Nathan, additional, Gaillard, William, additional, Glauser, Tracy, additional, Goodkin, Howard, additional, Jackson, Michele, additional, Mikati, Mohamad, additional, Peariso, Katrina, additional, Rathore, Geetanjali, additional, Tasker, Robert, additional, Topjian, Alexis, additional, Turner, David, additional, Wilfong, Angus, additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2014
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37. Etiology of Pediatric Refractory Convulsive Status Epilepticus. Results from the Pediatric Status Epilepticus Research Group (pSERG) (S29.005)

Author

Gaillard, William, primary, Goodkin, Howard, additional, Abend, Nicholas, additional, Agadi, Satish, additional, Arya, Ravindra, additional, Basu, Rajit, additional, Carpenter, Jessica, additional, Chapman, Kevin, additional, Dean, Nathan, additional, Glauser, Tracy, additional, Jackson, Michele, additional, Mikati, Mohamad, additional, Peariso, Katrina, additional, Rathore, Geetanjali, additional, Sanchez Fernandez, Ivan, additional, Tasker, Robert, additional, Topjian, Alexis, additional, Turner, David, additional, Wilfong, Angus, additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2014
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38. Electrographic Seizures after Convulsive Status Epilepticus in Children and Young Adults: A Retrospective Multicenter Study

Author

Sánchez Fernández, Iván, primary, Abend, Nicholas S., additional, Arndt, Daniel H., additional, Carpenter, Jessica L., additional, Chapman, Kevin E., additional, Cornett, Karen M., additional, Dlugos, Dennis J., additional, Gallentine, William B., additional, Giza, Christopher C., additional, Goldstein, Joshua L., additional, Hahn, Cecil D., additional, Lerner, Jason T., additional, Matsumoto, Joyce H., additional, McBain, Kristin, additional, Nash, Kendall B., additional, Payne, Eric, additional, Sánchez, Sarah M., additional, Williams, Korwyn, additional, and Loddenkemper, Tobias, additional

Published
2014
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39. Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus

Author

Gaínza-Lein, Marina, Sánchez Fernández, Iván, Jackson, Michele, Abend, Nicholas S., Arya, Ravindra, Brenton, J. Nicholas, Carpenter, Jessica L., Chapman, Kevin E., Gaillard, William D., Glauser, Tracy A., Goldstein, Joshua L., Goodkin, Howard P., Kapur, Kush, Mikati, Mohamad A., Peariso, Katrina, Tasker, Robert C., Tchapyjnikov, Dmitry, Topjian, Alexis A., Wainwright, Mark S., Wilfong, Angus, Williams, Korwyn, and Loddenkemper, Tobias

Abstract

IMPORTANCE: Treatment delay for seizures can lead to longer seizure duration. Whether treatment delay is associated with major adverse outcomes, such as death, remains unknown. OBJECTIVE: To evaluate whether untimely first-line benzodiazepine treatment is associated with unfavorable short-term outcomes. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, observational, prospective cohort study included 218 pediatric patients admitted between June 1, 2011, and July 7, 2016, into the 11 tertiary hospitals in the United States within the Pediatric Status Epilepticus Research Group. Patients, ranging in age from 1 month to 21 years, with refractory convulsive status epilepticus (RCSE) that did not stop after the administration of at least 2 antiseizure medications were included. Patients were divided into 2 cohorts: those who received the first-line benzodiazepine treatment in less than 10 minutes and those who received it 10 or more minutes after seizure onset (untimely). Data were collected and analyzed from June 1, 2011, to July 7, 2016. MAIN OUTCOMES AND MEASURES: The primary outcome was death during the related hospital admission. The secondary outcome was the need for continuous infusion for seizure termination. Multivariate analysis of mortality controlled for structural cause, febrile RCSE, age, and previous neurological history (including previous RCSE events). Use of continuous infusions was additionally adjusted for generalized RCSE, continuous RCSE, and 5 or more administrations of antiseizure medication. RESULTS: A total of 218 patients were included, among whom 116 (53.2%) were male and the median (interquartile range) age was 4.0 (1.2-9.6) years. The RCSE started in the prehospital setting for 139 patients (63.8%). Seventy-four patients (33.9%) received their first-line benzodiazepine treatment in less than 10 minutes, and 144 (66.1%) received untimely first-line benzodiazepine treatment. Multivariate analysis showed that patients who received untimely first-line benzodiazepine treatment had higher odds of death (adjusted odds ratio [AOR], 11.0; 95% CI, 1.43 to ∞; P = .02), had greater odds of receiving continuous infusion (AOR, 1.8; 95% CI, 1.01-3.36; P = .047), had longer convulsive seizure duration (AOR, 2.6; 95% CI, 1.38-4.88; P = .003), and had more frequent hypotension (AOR 2.3; 95% CI, 1.16-4.63; P = .02). In addition, the timing of the first-line benzodiazepine treatment was correlated with the timing of the second-line (95% CI, 0.64-0.95; P < .001) and third-line antiseizure medications (95% CI, 0.25-0.78; P < .001). CONCLUSIONS AND RELEVANCE: Among pediatric patients with RCSE, an untimely first-line benzodiazepine treatment is independently associated with a higher frequency of death, use of continuous infusions, longer convulsion duration, and more frequent hypotension. Results of this study raise the question as to whether poor outcomes could, in part, be prevented by earlier administration of treatment.

Published
2018
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40. How the International Classification of Diseases, Tenth Revision, Clinical ModificationAffects Coding for Pediatric Diagnoses

Author

Williams, Korwyn

Abstract

Accurate coding is important for proper reimbursement and documentation of care provided. Recent changes in disease classification systems have affected the coding for pediatric diagnoses. This article provides an overview of coding considerations for pediatric diagnoses, including coding for intellectual disabilities and congenital malformations.

Published
2018
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47. Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality.

Author

Abend, Nicholas S, Arndt, Daniel H, Carpenter, Jessica L, Chapman, Kevin E, Cornett, Karen M, Gallentine, William B, Giza, Christopher C, Goldstein, Joshua L, Hahn, Cecil D, Lerner, Jason T, Loddenkemper, Tobias, Matsumoto, Joyce H, McBain, Kristin, Nash, Kendall B, Payne, Eric, Sánchez, Sarah M, Fernández, Iván Sánchez, Shults, Justine, Williams, Korwyn, and Yang, Amy

Published
2013
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49. Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus.

Author

Sheehan T, Amengual-Gual M, Vasquez A, Abend NS, Anderson A, Appavu B, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Jackson M, Kapur K, Kahoud R, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sands TT, Sannagowdara K, Shellhaas R, Smith G, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Zhang B, and Loddenkemper T

Subjects
Anticonvulsants therapeutic use, Benzodiazepines therapeutic use, Child, Child, Preschool, Humans, Retrospective Studies, Seizures drug therapy, Drug Resistant Epilepsy drug therapy, Status Epilepticus drug therapy
Abstract

Objective: This study was undertaken to evaluate benzodiazepine (BZD) administration patterns before transitioning to non-BZD antiseizure medication (ASM) in pediatric patients with refractory convulsive status epilepticus (rSE)., Methods: This retrospective multicenter study in the United States and Canada used prospectively collected observational data from children admitted with rSE between 2011 and 2020. Outcome variables were the number of BZDs given before the first non-BZD ASM, and the number of BZDs administered after 30 and 45 min from seizure onset and before escalating to non-BZD ASM., Results: We included 293 patients with a median (interquartile range) age of 3.8 (1.3-9.3) years. Thirty-six percent received more than two BZDs before escalating, and the later the treatment initiation was after seizure onset, the less likely patients were to receive multiple BZD doses before transitioning (incidence rate ratio [IRR] = .998, 95% confidence interval [CI] = .997-.999 per minute, p = .01). Patients received BZDs beyond 30 and 45 min in 57.3% and 44.0% of cases, respectively. Patients with out-of-hospital seizure onset were more likely to receive more doses of BZDs beyond 30 min (IRR = 2.43, 95% CI = 1.73-3.46, p < .0001) and beyond 45 min (IRR = 3.75, 95% CI = 2.40-6.03, p < .0001) compared to patients with in-hospital seizure onset. Intermittent SE was a risk factor for more BZDs administered beyond 45 min compared to continuous SE (IRR = 1.44, 95% CI = 1.01-2.06, p = .04). Forty-seven percent of patients (n = 94) with out-of-hospital onset did not receive treatment before hospital arrival. Among patients with out-of-hospital onset who received at least two BZDs before hospital arrival (n = 54), 48.1% received additional BZDs at hospital arrival., Significance: Failure to escalate from BZDs to non-BZD ASMs occurs mainly in out-of-hospital rSE onset. Delays in the implementation of medical guidelines may be reduced by initiating treatment before hospital arrival and facilitating a transition to non-BZD ASMs after two BZD doses during handoffs between prehospital and in-hospital settings., (© 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)

Published
2021
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50. Factors associated with long-term outcomes in pediatric refractory status epilepticus.

Author

Gaínza-Lein M, Barcia Aguilar C, Piantino J, Chapman KE, Sánchez Fernández I, Amengual-Gual M, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Clark J, Farias-Moeller R, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Huh L, Kahoud R, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Nayak A, Novotny E Jr, Ostendorf AP, Payne ET, Peariso K, Reece L, Riviello J, Sannagowdara K, Sands TT, Sheehan T, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Zhang B, and Loddenkemper T

Subjects
Anticonvulsants therapeutic use, Child, Epilepsy, Generalized drug therapy, Female, Hospital Mortality, Humans, Male, Retrospective Studies, Seizures drug therapy, Status Epilepticus diagnosis, Status Epilepticus epidemiology, Status Epilepticus therapy
Abstract

Objective: This study was undertaken to describe long-term clinical and developmental outcomes in pediatric refractory status epilepticus (RSE) and identify factors associated with new neurological deficits after RSE., Methods: We performed retrospective analyses of prospectively collected observational data from June 2011 to March 2020 on pediatric patients with RSE. We analyzed clinical outcomes from at least 30 days after RSE and, in a subanalysis, we assessed developmental outcomes and evaluated risk factors in previously normally developed patients., Results: Follow-up data on outcomes were available in 276 patients (56.5% males). The median (interquartile range [IQR]) follow-up duration was 1.6 (.9-2.7) years. The in-hospital mortality rate was 4% (16/403 patients), and 15 (5.4%) patients had died after hospital discharge. One hundred sixty-six (62.9%) patients had subsequent unprovoked seizures, and 44 (16.9%) patients had a repeated RSE episode. Among 116 patients with normal development before RSE, 42 of 107 (39.3%) patients with available data had new neurological deficits (cognitive, behavioral, or motor). Patients with new deficits had longer median (IQR) electroclinical RSE duration than patients without new deficits (10.3 [2.1-134.5] h vs. 4 [1.6-16] h, p = .011, adjusted odds ratio = 1.003, 95% confidence interval = 1.0008-1.0069, p = .027). The proportion of patients with an unfavorable functional outcome (Glasgow Outcome Scale-Extended score ≥ 4) was 22 of 90 (24.4%), and they were more likely to have received a continuous infusion., Significance: About one third of patients without prior epilepsy developed recurrent unprovoked seizures after the RSE episode. In previously normally developing patients, 39% presented with new deficits during follow-up, with longer electroclinical RSE duration as a predictor., (© 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)

Published
2021
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