301 results on '"Williams EL"'
Search Results
2. Elegy for the Gnat
- Author
-
WILLIAMS, EL
- Published
- 2021
3. Severe acute neurotoxicity reflects absolute intra-carotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine dose in non-human primates
- Author
-
Norris, SA, White, HCB, Tanenbaum, A., Williams, EL, Cruchaga, C., Tian, L., Schmidt, RE, and Perlmutter, JS
- Published
- 2022
- Full Text
- View/download PDF
4. Diketopyrrolopyrrole-based polymer:fullerene nanoparticle films with thermally stable morphology for organic photovoltaic applications
- Author
-
Holmes, NP, Vaughan, B, Williams, EL, Kroon, R, Anderrson, MR, Kilcoyne, ALD, Sonar, P, Zhou, X, Dastoor, PC, and Belcher, WJ
- Subjects
Bioengineering ,Nanotechnology ,Materials Engineering - Abstract
Polymer:fullerene nanoparticles (NPs) offer two key advantages over bulk heterojunction (BHJ) films for organic photovoltaics (OPVs), water-processability and potentially superior morphological control. Once an optimal active layer morphology is reached, maintaining this morphology at OPV operating temperatures is key to the lifetime of a device. Here we study the morphology of the PDPP-TNT (poly{3,6-dithiophene-2-yl-2,5-di(2-octyldodecyl)-pyrrolo[3,4-c]pyrrole-1,4-dione-alt-naphthalene}):PC71BM ([6,6]-phenyl C71 butyric acid methyl ester) NP system and then compare the thermal stability of NP and BHJ films to the common poly(3-hexylthiophene) (P3HT): phenyl C61 butyric acid methyl ester (PC61BM) system. We find that material T g plays a key role in the superior thermal stability of the PDPP-TNT:PC71BM system; whereas for the P3HT:PC61BM system, domain structure is critical.
- Published
- 2017
5. Biotin supplementation causes erroneous elevations of results in some commercial serum 25-hydroxyvitamin d (25OHD) assays
- Author
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Carter, GD, Berry, J, Cavalier, E, Durazo-Arvizu, R, Gunter, E, Jones, G, Jones, J, Phinney, K, Sempos, CT, Twomey, PJ, and Williams, EL
- Published
- 2020
- Full Text
- View/download PDF
6. There Was a Brood
- Author
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Williams, El, III
- Subjects
There Was a Brood (Poem) ,Literature/writing - Abstract
rude with loudness. its overarching chorus of song and sex. fat flying insects, once buried in the pockets of this town. loosened, and. flamboyantly doing their business in the trees, [...]
- Published
- 2023
7. The effectiveness of heat preparation and alleviation strategies for cognitive performance: A systematic review
- Author
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Donnan, KJ, Williams, EL, Bargh, MJ, Donnan, KJ, Williams, EL, and Bargh, MJ
- Abstract
A range of occupational and performance contexts (e.g. military personnel operations, emergency services, sport) require the critical maintenance of cognitive performance in environmentally challenging environments. Several reviews exist which evaluate the effectiveness of heat preparation strategies to facilitate physical performance. To date, no review has explored the usefulness of heat preparation strategies for cognitive performance. Therefore, this systematic review aimed to evaluate a range of interventions for the maintenance of cognitive performance, during or following active or passive heat exposure. Studies to be included were assessed by two authors reviewing title, abstract, and full-text. Forty articles were identified which met the inclusion criteria. Interventions were categorised into chronic (i.e. acclimation/acclimatisation) and acute strategies (i.e. hydration, cooling, supplementation, psychological). The results indicate that medium-term consecutive heat acclimation may mitigate some cognitive deficits under heat stress, although heat acclimation effectiveness could be influenced by age. Further, pre-cooling appears the most effective cooling method for maintaining cognitive performance under heat stress, although results were somewhat ambiguous. The hydration literature showed that the most effective hydration strategies were those which individualised electrolyte fortified fluid volumes to match for sweat loss. Limited research exploring psychological interventions indicates that motivational self-talk could be facilitative for maintaining cognitive skills following exercise in hot conditions. These findings can be used to help inform strategies for maintaining critical cognitive and decision-making skills in hot environments.
- Published
- 2023
8. Petrichor
- Author
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Williams, El, III
- Subjects
Petrichor (Williams, El, III) (Poem) ,Literature/writing - Abstract
foraging, my friend leaves the lonely forest with golden chanterelles. beneath our feet, each dead leaf a disappearing lyric, seeping in- to the deep brown sea of mud. the air [...]
- Published
- 2023
9. The effect of exercise-induced fatigue and heat exposure on soccer-specific decision-making during high-intensity intermittent exercise.
- Author
-
Donnan, KJ, Williams, EL, Stanger, N, Donnan, KJ, Williams, EL, and Stanger, N
- Abstract
Global warming and the globalisation of sport has increased the prevalence of sports competitions being held in hot environments. However, there is currently limited research investigating the impact of the heat on soccer-specific decision-making skills during exercise reflective of the physical demands of match-play. Therefore, the effects of heat exposure on physical and soccer-specific decision-making performance, biological markers (i.e., metanephrines), appraisal (i.e., challenge vs. threat) and affective states, during prolonged high-intensity intermittent exercise were investigated. Nine well-trained male soccer players completed a 92-min cycling intermittent sprint protocol (CISP), whilst simultaneously responding to a series of soccer-specific decision-making trials at various time points, in two temperature conditions: hot (32°C, 50%rh) and temperate (18°C, 50%rh). Results showed that decision-making score (p = .030) was impaired in the hot compared to the temperate condition. There was a reduced workload in the second half during the hot condition (p = .016), which coincided with a heightened threat state (p = .007) and more unpleasant feelings (p = .008) experienced in the hot, compared to temperate, condition. Furthermore, plasma normetanephrine (NMET) was higher at half-time (p = .012) and post-CISP (p ≤ .001). Also, plasma metanephrine (MET) was higher post-CISP (p = .009) in the hot compared to temperate condition, reflecting a heightened stress response. Our findings highlight the need for practitioners to consider the detrimental effects heat exposure can have on both physical and decision-making performance when looking to facilitate performance in hot conditions.
- Published
- 2022
10. The effects of exercise at different temperatures on cognitive function: A systematic review
- Author
-
Donnan, K, Williams, EL, Morris, JL, Stanger, N, Donnan, K, Williams, EL, Morris, JL, and Stanger, N
- Published
- 2021
11. An investigation of expertise in cycling : Eye tracking, Think Aloud and the influence of a competitor
- Author
-
Massey, HS, Whitehead, AE, Marchant, D, Polman, RC, Williams, EL, Massey, HS, Whitehead, AE, Marchant, D, Polman, RC, and Williams, EL
- Published
- 2020
12. Changes in Cognition over a 16.1 km Cycling Time Trial using Think Aloud Protocol: Preliminary Evidence
- Author
-
Whitehead, AE, Jones, HJ, Williams, EL, Dowling, C, Morley, D, Taylor, JA, Polman, RC, Whitehead, AE, Jones, HJ, Williams, EL, Dowling, C, Morley, D, Taylor, JA, and Polman, RC
- Abstract
Objectives: This study investigated cognitions of cyclists during a competitive time trial (TT) event using Think Aloud (TA) protocol analysis. Design: Single group, observational design. Method: Fifteen male and three female cyclists from the North West of England verbalised their thoughts throughout an outdoor competitive 16.1 km cycling TT (Level 2 TA). Verbalisations were recorded using iVue Horizon 1080P camera glasses. Data were transcribed verbatim, analysed using deductive content analysis and grouped into themes: (i) Pain And Discomfort (Fatigue, Pain), (ii) External Feedback (Time, Speed, Heart Rate), (iii) Environment (Surroundings, Traffic and Other Cyclists), and (iv) Pace and Distance (Pace, Distance). The number of verbalisations within each theme was analysed by distance quartile using Friedman tests to examine changes in cognitions over time. Results: Associative themes, including Fatigue and Pain, were verbalised more frequently in the earlier stages of the TT and less in the final quartile, whereas verbalisations about Distance significantly increased in the last quartile. Conclusions: This study demonstrates how a novel data collection method can capture in-event cognitions of endurance athletes. It provides an important extension to previous literature, showing how individuals may process and attend to information over time during an exercise bout. Future research should establish the relationship between performance and cognitive processes.
- Published
- 2019
13. Investigating the relationship between cognitions, pacing strategies and performance in 16.1 km cycling time trials using a think aloud protocol
- Author
-
Whitehead, AE, Jones, HS, Williams, EL, Rowley, C, Quayle, L, Marchant, D, and Polman, RC
- Abstract
© 2017 Objectives Three studies involved the investigation of concurrent cognitive processes and pacing behaviour during a 16.1 km cycling time trial (TT) using a novel Think Aloud (TA) protocol. Study 1 examined trained cyclist's cognitions over time whilst performing a real-life 16.1 km time trial (TT), using TA protocol. Study 2, included both trained and untrained participants who performed a 16.1 km TT in a laboratory whilst using TA. Study 3 investigated participants' experiences of using TA during a TT performance. Method Study 1 involved 10 trained cyclists performing a real life 16.1 km TT. Study 2 included 10 trained and 10 untrained participants who performed a laboratory-based 16.1 km TT. In both studies, all participants were asked to TA. Time, power output, speed and heart rate were measured. Verbalisations were coded into the following themes (i) internal sensory monitoring, (ii) active self-regulation, (iii) outward monitoring (iv) distraction. Cognitions and pacing strategies were compared between groups and across the duration of the TT. In study 3 all participants were interviewed post TT to explore perceptions of using TA. Results Study 1 and 2 found cognitions and pacing changed throughout the TT. Active self-regulation was verbalised most frequently. Differences were found between laboratory and field verbalisations and trained and untrained participants. Study 3 provided support for the use of TA in endurance research. Recommendations were provided for future application. Conclusion Through the use of TA this study has been able to contribute to the pacing and cycling literature and to the understanding of endurance athletes’ cognitions.
- Published
- 2018
14. Information acquisition differences of experienced and novice time trial cyclists
- Author
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Boya, M, Foulsham, T, Hettinga, F, Parry, D, Williams, EL, Jones, HJ, Sparks, A, Marchant, D, Ellison, P, Bridge, CA, McNaughton, L, and Micklewright, D
- Published
- 2017
15. Presence of Spotters Improves Bench Press Performance: A Deception Study.
- Author
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Sheridan, A, Marchant, DC, Williams, EL, Jones, HS, Hewitt, PA, Sparks, SA, Sheridan, A, Marchant, DC, Williams, EL, Jones, HS, Hewitt, PA, and Sparks, SA
- Abstract
Sheridan, A, Marchant, DC, Williams, EL, Jones, HS, Hewitt, PA, and Sparks, SA. Presence of spotters improves bench press performance: a deception study. J Strength Cond Res XX(X): 000-000, 2017-Resistance exercise is a widely used method of physical training in both recreational exercise and athletic populations. The use of training partners and spotters during resistance exercise is widespread, but little is known about the effect of the presence of these individuals on exercise performance. The purpose of the current study was to investigate the effect of spotter presence on bench press performance. Twelve recreationally trained participants (age, 21.3 ± 0.8 years, height, 1.82 ± 0.1 m, and weight, 84.8 ± 11.1 kg) performed 2 trials of 3 sets to failure at 60% of 1 repetition maximum on separate occasions. The 2 trials consisted of spotters being explicitly present or hidden from view (deception). During the trials, total repetitions (reps), total weight lifted, ratings of perceived exertion (RPE), and self-efficacy were measured. Total reps and weight lifted were significantly greater with spotters (difference = 4.5 reps, t = 5.68, p < 0.001 and difference = 209.6 kg, t = 5.65, p < 0.001, respectively). Although RPE and local RPE were significantly elevated in the deception trials (difference = 0.78, f = 6.16, p = 0.030 and difference = 0.81, f = 5.89, p = 0.034, respectively), self-efficacy was significantly reduced (difference = 1.58, f = 26.90, p < 0.001). This study demonstrates that resistance exercise is improved by the presence of spotters, which is facilitated by reduced RPE and increased self-efficacy. This has important implications for athletes and clients, who should perform resistance exercise in the proximity of others, to maximize total work performed.
- Published
- 2017
16. To align or not to align? Research methods and its relationship with dissertation marks across sport undergraduate degree programmes within a UK-based HE institution
- Author
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Houghton, LJ, Williams, EL, Jones, HJ, Page, RM, Bostock, J, Houghton, LJ, Williams, EL, Jones, HJ, Page, RM, and Bostock, J
- Abstract
Much research has referred to the complexity of research methods modules within undergraduate degree programmes. Less attention has been paid to the objective understanding of alignment between research methods and final year dissertations. This study explored relationships across Sport and Exercise Science (SES) and Sports Therapy (ST) programmes within a UK-based Higher Education institution. Analysis revealed females (N=73) outperformed males (N=117) at Levels 4/5, and SES students outperformed ST at Level 6. The Level 5 statistics assessment explained the lowest variance in the dissertation, suggesting poor alignment in curriculum design. Future research should consider the efficacy of statistics-based modules.
- Published
- 2017
17. Sodium bicarbonate ingestion and individual variability in time to peak pH
- Author
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Sparks, A, Williams, EL, Robinson, A, Miller, P, Bentley, D, Bridge, CA, and McNaughton, L
- Abstract
The aim of this study was to determine the individual variability in time to peak pH after the consumption of a 300mg.kg-1 dose of sodium bicarbonate (NaHCO3). Seventeen active males volunteered to participate in the study (mean ± SD: age 21.38 ± 1.5y; mass 75.8 ± 5.8kg; height 176.8 ± 7.6cm). Participants reported to the laboratory where a resting capillary blood sample was taken aseptically from the fingertip. After this, 300 mg.kg-1 of NaHCO3 in 400ml of water with 50ml of flavoured cordial was ingested. Participants then rested for 90 min during which repeated blood samples were procured at 10 minute intervals for 60 mins and then every 5 min until 90 min. Blood pH concentrations were measured using a blood gas analyser. Results suggested that time to peak pH (64.41±18.78 min) was highly variable with a range of 10-85 min and a coefficient of variation of 29.16%. A bi-modal distribution occurred, at 65 and 75 min. In conclusion, researchers and athletes, when using NaHCO3 as an ergogenic aid, should determine, in advance their time to peak pH to best utilise the added buffering capacity this substance allows.
- Published
- 2016
18. THE EFFECTS OF INFLAMMATORY CYTOKINES FROM ARTHRITIC SYNOVIUM ON SKELETAL STEM CELL FUNCTION-IMPLICATIONS FOR REPARATIVE STRATEGIES
- Author
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Williams, EL, Roach, HI, Cooper, C, Oreffo, RO, and Edwards, CJ
- Published
- 2016
19. Occurrence of Infected Amoebae in Cooling Towers Compared with Natural Aquatic Environments: Implications for Emerging Pathogens
- Author
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Sharon G. Berk, Anthony L. Farone, Farsian M, Uddin N, Williams El, Gunderson Jh, Anthony L. Newsome, Johnson Ra, Skimmyhorn J, Mary B. Farone, Hayes Bj, Reid A, and Redding Ks
- Subjects
Legionella ,Molecular Sequence Data ,Fresh Water ,chemical and pharmacologic phenomena ,Human pathogen ,macromolecular substances ,Natural (archaeology) ,Legionella pneumophila ,Odds Ratio ,Animals ,Environmental Chemistry ,Air Conditioning ,Cooling tower ,Amoeba ,DNA Primers ,Base Sequence ,biology ,Ecology ,Aquatic ecosystem ,Computational Biology ,Sequence Analysis, DNA ,General Chemistry ,Hydrogen-Ion Concentration ,biochemical phenomena, metabolism, and nutrition ,biology.organism_classification ,Tennessee ,Carbon ,respiratory tract diseases ,Logistic Models ,Aquatic environment ,Protozoa ,Water Microbiology ,Bacteria ,Environmental Monitoring ,circulatory and respiratory physiology - Abstract
Many species of bacteria pathogenic to humans, such as Legionella, are thought to have evolved in association with amoebal hosts. Several novel unculturable bacteria related to Legionella have also been found in amoebae, a few of which have been thought to be causes of nosocomial infections in humans. Because amoebae can be found in cooling towers, we wanted to know whether cooling tower environments might enhance the association between amoebae and bacterial pathogens of amoebae in order to identify potential "hot spots" for emerging human pathogens. To compare occurrence of infected amoebae in natural environments with those in cooling towers, 40 natural aquatic environments and 40 cooling tower samples were examined. Logistic regression analysis determined variables that were significant predictors of the occurrence of infected amoebae, which were found in 22 of 40 cooling tower samples but in only 3 of the 40 natural samples. An odds ratio showed that it is over 16 times more likely to encounter infected amoebae in cooling towers than in natural environments. Environmental data from cooling towers and natural habitats combined revealed dissolved organic carbon (DOC) and pH were predictors of the occurrence of the pathogens, however, when cooling tower data alone were analyzed, no variables accounted for the occurrence. Several bacteria have novel rRNA sequences, and most strains were not culturable outside of amoebae. Such pathogens of amoebae may spread to the environment via aerosols from cooling towers. Studies of emerging infectious diseases should strongly consider cooling towers as a source of amoeba-associated pathogens.
- Published
- 2006
- Full Text
- View/download PDF
20. Probably Something about the Grass.
- Author
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Williams, El III
- Subjects
GRASSES - Abstract
This document is a poem titled "Probably Something about the Grass" by El Williams III. The poem reflects on the concept of softness and the fleeting nature of life, particularly through the imagery of grass. The poet contemplates the idea of reckoning and the importance of taking action in the face of uncertainty. The poem also touches on the power of language and the role of smallness in the world. El Williams III is a St. Louis native and a doctoral student studying literature and creative writing at the University of Houston. [Extracted from the article]
- Published
- 2024
21. Test-retest reliability of a 16.1 km time trial in trained cyclists using the CompuTrainer ergometer
- Author
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Sparks, Andy, Williams, EL, Jones, HJ, Bridge, CA, Marchant, David, McNaughton, Lars, Sparks, Andy, Williams, EL, Jones, HJ, Bridge, CA, Marchant, David, and McNaughton, Lars
- Abstract
Laboratory based cycling time trials (TT) are widely used by both researchers and practitioners, as a method of assessing cycling performance in a controlled environment. Assessments of performance often use TT durations or distances between 20 min and one hour and in the UK the 10 mile (16.1 km) TT is the most frequently used race distance for trained cyclists. The 16.1 km TT has received relatively minimal, but increased attention as a performance criterion in the literature. Therefore, the aim of this study was to assess the reliability of 16.1 km TT performance in a large cohort of trained cyclists using the CompuTrainer cycling ergometer. Trained male cyclists (n = 58, mean±SD age 35±7 yr, height 179±6 cm, weight 79.1±9.4 kg, VO2max. 56.6±6.6 ml.kg.min-1, PPO 365±37 W) performed an initial incremental exercise test to determine PPO and VO2max. The participants then performed two 16.1 km TT on a CompuTrainer cycle ergometer separated by 3-7 days. Differences in time, power output and speed were determined using a Wilcoxon signed ranks or paired t-tests. Reproducibility of the TT performance measures was performed using the coefficient of variation (CV), intraclass correlations, and typical error (TE). There were no differences between any of the performance criteria for the whole cohort (Mean difference = 0.06 min, 0.09 km.h-1, 1.5 W, for time, mean speed and power respectively) between TT1 and TT2. All TT performance data were very reproducible (CV range = 1.1-2.7%) and demonstrated trivial or small TE. The slower cyclists demonstrated marginally lower reliability (CV range = 1.3-3.2%) compared to the fastest group (CV range = 0.7-2.0%). The 16.1 km TT on the CompuTrainer represents a very reliable performance criterion for trained cyclists. Interpretation of test-retest performance outcomes should be performed in the context of the TE of each performance indicator.
- Published
- 2016
22. Improvements in cycling time trial performance are not sustained following the acute provision of challenging and deceptive feedback
- Author
-
Massey, Hollie, Williams, EL, Marchant, D, Sparks, A, Bridge, CA, Midgley, AW, McNaughton, LR, Massey, Hollie, Williams, EL, Marchant, D, Sparks, A, Bridge, CA, Midgley, AW, and McNaughton, LR
- Abstract
The provision of performance-related feedback during exercise is acknowledged as an influential external cue used to inform pacing decisions. The provision of this feedback in a challenging or deceptive context allows research to explore how feedback can be used to improve performance and influence perceptual responses. However, the effects of deception on both acute and residual responses have yet to be explored, despite potential application for performance enhancement. Therefore, this study investigated the effects of challenging and deceptive feedback on perceptual responses and performance in self-paced cycling time trials (TT) and explored whether changes in performance are sustained in a subsequent TT following the disclosure of the deception. Seventeen trained male cyclists were assigned to either an accurate or deceptive feedback group and performed four 16.1 km cycling TTs; (1 and 2) ride-alone baseline TTs where a fastest baseline (FBL) performance was identified, (3) a TT against a virtual avatar representing 102% of their FBL performance (PACER), and (4) a subsequent ride-alone TT (SUB). The deception group, however, were initially informed that the avatar accurately represented their FBL, but prior to SUB were correctly informed of the nature of the avatar. Affect, self-efficacy and RPE were measured every quartile. Both groups performed PACER faster than FBL and SUB (p < 0.05) and experienced lower affect (p = 0.016), lower self-efficacy (p = 0.011), and higher RPE (p < 0.001) in PACER than FBL. No significant differences were found between FBL and SUB for any variable. The presence of the pacer rather than the manipulation of performance beliefs acutely facilitates TT performance and perceptual responses. Revealing that athletes' performance beliefs were falsely negative due to deceptive feedback provision has no effect on subsequent perceptions or performance. A single experiential exposure may not be sufficient to produce meaningful changes in the
- Published
- 2016
23. Deception has no acute or residual effect on cycling time trial performance but negatively effects perceptual responses
- Author
-
Massey, Hollie, Williams, EL, Marchant, DC, Sparks, SA, Bridge, CA, Midgley, AW, Mc Naughton, LR, Massey, Hollie, Williams, EL, Marchant, DC, Sparks, SA, Bridge, CA, Midgley, AW, and Mc Naughton, LR
- Abstract
OBJECTIVES: Feedback deception is used to explore the importance of expectations on pacing strategy and performance in self-paced exercise. The deception of feedback from a previous performance explores the importance of experience knowledge on exercise behaviour. This study aimed to explore the acute and residual effects of the deception of previous performance speed on perceptual responses and performance in cycling time trials. DESIGN: A parallel-group design. METHODS: Twenty cyclists were assigned to a control or deception group and performed 16.1km time trials. Following a ride-alone baseline time trial (FBL), participants performed against a virtual avatar representing their FBL performance (PACER), then completed a subsequent ride-alone time trial (SUB). The avatar in the deception group, however, was unknowingly set 2% faster than their FBL. RESULTS: Both groups performed faster in PACER than FBL and SUB (p<0.05), but SUB was not significantly different to FBL. Affect was more negative and Ratings of Perceived Exertion (RPE) were higher in PACER than FBL in the deception group (p<0.05). CONCLUSIONS: The presence of a visual pacer acutely facilitated time trial performance, but deceptive feedback had no additional effect on performance. The deception group, however, experienced more negative affect and higher RPE in PACER, whereas these responses were absent in the control group. The performance improvement was not sustained in SUB, suggesting no residual performance effects occurred.
- Published
- 2016
24. Test-retest reliability of a 16.1 km time trial in trained cyclists using the CompuTrainer ergometer
- Author
-
Sparks, AS, Williams, EL, Jones, HJ, Bridge, CA, Marchant, D, McNaughton, L, Sparks, AS, Williams, EL, Jones, HJ, Bridge, CA, Marchant, D, and McNaughton, L
- Abstract
Laboratory based cycling time trials (TT) are widely used by both researchers and practitioners, as a method of assessing cycling performance in a controlled environment. Assessments of performance often use TT durations or distances between 20 min and one hour and in the UK the 10 mile (16.1 km) TT is the most frequently used race distance for trained cyclists. The 16.1 km TT has received relatively minimal, but increased attention as a performance criterion in the literature. Therefore, the aim of this study was to assess the reliability of 16.1 km TT performance in a large cohort of trained cyclists using the CompuTrainer cycling ergometer. Trained male cyclists (n = 58, mean±SD age 35±7 yr, height 179±6 cm, weight 79.1±9.4 kg, VO2max. 56.6±6.6 ml.kg.min-1, PPO 365±37 W) performed an initial incremental exercise test to determine PPO and VO2max. The participants then performed two 16.1 km TT on a CompuTrainer cycle ergometer separated by 3-7 days. Differences in time, power output and speed were determined using a Wilcoxon signed ranks or paired t-tests. Reproducibility of the TT performance measures was performed using the coefficient of variation (CV), intraclass correlations, and typical error (TE). There were no differences between any of the performance criteria for the whole cohort (Mean difference = 0.06 min, 0.09 km.h-1, 1.5 W, for time, mean speed and power respectively) between TT1 and TT2. All TT performance data were very reproducible (CV range = 1.1-2.7%) and demonstrated trivial or small TE. The slower cyclists demonstrated marginally lower reliability (CV range = 1.3-3.2%) compared to the fastest group (CV range = 0.7-2.0%). The 16.1 km TT on the CompuTrainer represents a very reliable performance criterion for trained cyclists. Interpretation of test-retest performance outcomes should be performed in the context of the TE of each performance indicator.
- Published
- 2016
25. Deceptive Manipulation of Competitive Starting Strategies Influences Subsequent Pacing, Physiological Status, and Perceptual Responses during Cycling Time Trials
- Author
-
Williams, EL, Jones, HS, Sparks, SA, Marchant, DC, Midgley, AW, Bridge, CA, McNaughton, LR, Williams, EL, Jones, HS, Sparks, SA, Marchant, DC, Midgley, AW, Bridge, CA, and McNaughton, LR
- Abstract
The provision of performance-related feedback during exercise is acknowledged as an influential external cue used to inform pacing decisions. The provision of this feedback in a challenging or deceptive context allows research to explore how feedback can be used to improve performance and influence perceptual responses. However, the effects of deception on both acute and residual responses have yet to be explored, despite potential application for performance enhancement. Therefore, this study investigated the effects of challenging and deceptive feedback on perceptual responses and performance in self-paced cycling time trials (TT) and explored whether changes in performance are sustained in a subsequent TT following the disclosure of the deception. Seventeen trained male cyclists were assigned to either an accurate or deceptive feedback group and performed four 16.1 km cycling TTs; 1 and 2) ride-alone baseline TTs where a fastest baseline (FBL) performance was identified, 3) a TT against a virtual avatar representing 102% of their FBL performance (PACER), and 4) a subsequent ride-alone TT (SUB). The deception group, however, were initially informed that the avatar accurately represented their FBL, but prior to SUB were correctly informed of the nature of the avatar. Affect, self-efficacy and RPE were measured every quartile. Both groups performed PACER faster than FBL and SUB (p < 0.05) and experienced lower affect (p = 0.016), lower self-efficacy (p = 0.011), and higher RPE (p < 0.001) in PACER than FBL. No significant differences were found between FBL and SUB for any variable. The presence of the pacer rather than the manipulation of performance beliefs acutely facilitates TT performance and perceptual responses. Revealing that athletes’ performance beliefs were falsely negative due to deceptive feedback provision has no effect on subsequent perceptions or performance. A single experiential exposure may not be sufficient to produce meaningful changes in the per
- Published
- 2016
26. Improvements in Cycling Time Trial Performance Are Not Sustained Following the Acute Provision of Challenging and Deceptive Feedback
- Author
-
Jones, HS, Williams, EL, Marchant, D, Sparks, A, Bridge, CA, Midgley, AW, McNaughton, LR, Jones, HS, Williams, EL, Marchant, D, Sparks, A, Bridge, CA, Midgley, AW, and McNaughton, LR
- Abstract
The provision of performance-related feedback during exercise is acknowledged as an influential external cue used to inform pacing decisions. The provision of this feedback in a challenging or deceptive context allows research to explore how feedback can be used to improve performance and influence perceptual responses. However, the effects of deception on both acute and residual responses have yet to be explored, despite potential application for performance enhancement. Therefore, this study investigated the effects of challenging and deceptive feedback on perceptual responses and performance in self-paced cycling time trials (TT) and explored whether changes in performance are sustained in a subsequent TT following the disclosure of the deception. Seventeen trained male cyclists were assigned to either an accurate or deceptive feedback group and performed four 16.1 km cycling TTs; 1 and 2) ride-alone baseline TTs where a fastest baseline (FBL) performance was identified, 3) a TT against a virtual avatar representing 102% of their FBL performance (PACER), and 4) a subsequent ride-alone TT (SUB). The deception group, however, were initially informed that the avatar accurately represented their FBL, but prior to SUB were correctly informed of the nature of the avatar. Affect, self-efficacy and RPE were measured every quartile. Both groups performed PACER faster than FBL and SUB (p < 0.05) and experienced lower affect (p = 0.016), lower self-efficacy (p = 0.011), and higher RPE (p < 0.001) in PACER than FBL. No significant differences were found between FBL and SUB for any variable. The presence of the pacer rather than the manipulation of performance beliefs acutely facilitates TT performance and perceptual responses. Revealing that athletes’ performance beliefs were falsely negative due to deceptive feedback provision has no effect on subsequent perceptions or performance. A single experiential exposure may not be sufficient to produce meaningful changes in the per
- Published
- 2016
27. Deception has no acute or residual effect on cycling time trial performance but negatively effects perceptual responses.
- Author
-
Jones, HS, Williams, EL, Marchant, DC, Sparks, SA, Bridge, CA, Midgley, AW, Mc Naughton, LR, Jones, HS, Williams, EL, Marchant, DC, Sparks, SA, Bridge, CA, Midgley, AW, and Mc Naughton, LR
- Abstract
Feedback deception is used to explore the importance of expectations on pacing strategy and performance in self-paced exercise. The deception of feedback from a previous performance explores the importance of experience knowledge on exercise behaviour. This study aimed to explore the acute and residual effects of the deception of previous performance speed on perceptual responses and performance in cycling time trials.A parallel-group design.Twenty cyclists were assigned to a control or deception group and performed 16.1km time trials. Following a ride-alone baseline time trial (FBL), participants performed against a virtual avatar representing their FBL performance (PACER), then completed a subsequent ride-alone time trial (SUB). The avatar in the deception group, however, was unknowingly set 2% faster than their FBL.Both groups performed faster in PACER than FBL and SUB (p<0.05), but SUB was not significantly different to FBL. Affect was more negative and Ratings of Perceived Exertion (RPE) were higher in PACER than FBL in the deception group (p<0.05).The presence of a visual pacer acutely facilitated time trial performance, but deceptive feedback had no additional effect on performance. The deception group, however, experienced more negative affect and higher RPE in PACER, whereas these responses were absent in the control group. The performance improvement was not sustained in SUB, suggesting no residual performance effects occurred.
- Published
- 2015
28. Altered Psychological Responses to Different Magnitudes of Deception during Cycling.
- Author
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Williams, EL, Jones, HS, Sparks, SA, Midgley, AW, Marchant, DC, Bridge, CA, McNaughton, LR, Williams, EL, Jones, HS, Sparks, SA, Midgley, AW, Marchant, DC, Bridge, CA, and McNaughton, LR
- Abstract
Purpose: Deceptive manipulations of performance intensity have previously been investigated in cycling time trials (TT) but used different magnitudes, methods, and task durations. This study examines previously used magnitudes of deception during 16.1-km TT and explores yet unexamined psychological responses. Methods: Twelve trained cyclists completed five TT, performing two baseline trials alone, one against a simulated dynamic avatar representing 102% of fastest baseline trial (TT102%), one against a 105% avatar (TT105%), and one against both avatars (TT102%,105%). Results: Deceptive use of competitors to disguise intensity manipulation enabled accomplishment of performance improvements greater than their perceived maximal (1.3%–1.7%). Despite a similar improvement in performance, during TT102%,105%, there was significantly lower affect and self-efficacy to continue pace than those during TT105%(P < 0.05), significantly lower self-efficacy to compete than that during TT102% (P = 0.004), and greater RPE than that during TTFBL (P < 0.001). Conclusions: Because the interpretation of performance information and perceptions depends on the manner in which it is presented, i.e., ‘‘framing effect,’’ it could be suggested that the summative effect of two opponents could have evoked negative perceptions despite eliciting a similar performance. Magnitudes of deception produce similar performance enhancement yet elicit diverse psychological responses mediated by the external competitive environment the participants were performing in.
- Published
- 2015
29. Competitor presence reduces internal attentional focus and improves 16.1km cycling time trial performance.
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Williams, EL, Jones, HS, Sparks, A, Marchant, DC, Midgley, AW, Mc Naughton, LR, Williams, EL, Jones, HS, Sparks, A, Marchant, DC, Midgley, AW, and Mc Naughton, LR
- Abstract
Objectives: Whilst the presence of a competitor has been found to improve performance, the mechanisms influencing the change in selected work rates during direct competition have been suggested but not specifically assessed. The aim was to investigate the physiological and psychological influences of a visual avatar competitor during a 16.1-km cycling time trial performance, using trained, competitive cyclists. Design: Randomised cross-over design. Methods: Fifteen male cyclists completed four 16.1 km cycling time trials on a cycle ergometer, performing two with a visual display of themselves as a simulated avatar (FAM and SELF), one with no visual display(DO), and one with themselves and an opponent as simulated avatars (COMP). Participants were informed the competitive avatar was a similar ability cyclist but it was actually a representation of their fastest previous performance. Results: Increased performance times were evident during COMP (27.8 ± 2.0 min) compared to SELF(28.7 ± 1.9 min) and DO (28.4 ± 2.3 min). Greater power output, speed and heart rate were apparent during COMP trial than SELF (p < 0.05) and DO (p ≤ 0.06). There were no differences between SELF and DO.Ratings of perceived exertion were unchanged across all conditions. Internal attentional focus was significantly reduced during COMP trial (p < 0.05), suggesting reduced focused on internal sensations during an increase in performance. Conclusions: Competitive cyclists performed significantly faster during a 16.1-km competitive trial than when performing maximally, without a competitor. The improvement in performance was elicited due to a greater external distraction, deterring perceived exertion.
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- 2015
30. Distance-dependent association of affect with pacing strategy in cycling time trials.
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Jones, HS, Williams, EL, Marchant, D, Sparks, SA, Midgley, AW, Bridge, CA, McNaughton, L, Jones, HS, Williams, EL, Marchant, D, Sparks, SA, Midgley, AW, Bridge, CA, and McNaughton, L
- Abstract
The psychological construct of affect is proposed to significantly contribute to pacing decisions during exercise. Borg’s RPE scale, another important regulator of work rate, is criticized as an inadequate measure of the multiple perceptual responses experienced. This study aimed to examine power output distribution and associated changes in affect, self-efficacy, perceptual cues, HR, and respiratory gases during both 16.1- and 40-km self-paced cycling time trials (TT). Secondly, the differentiation between physical perceptions of exertion and sense of effort in self-paced exercise was investigated. Method: Fifteen trained male cyclists completed 16.1- and 40-km TT using a CompuTrainer cycle ergometer. Time, power output distribution, affect, self-efficacy, physical RPE (P-RPE), task effort and awareness (TEA), HR, and respiratory gases were measured throughout each TT. Linear mixed models explored associations of these variables with power output distribution and the relationship between P-RPE and TEA. Results: Similar pacing strategies were adopted in the 16.1- and 40-km TT (P = 0.31), and the main effects were found for affect (P = 0.001) and RER (P G 0.001). Interactions between affect (P = 0.037) and RER (P = 0.004), with condition, indicated closer associations with power output distribution in 16.1 km than that in 40 km TT. P-RPE was not significantly different from TEA (P = 0.053). Conclusion: A significant association between affect and power output distribution suggests that affective responses are task dependent even in self-paced exercise, and a greater association is demonstrated in higher intensity, 16.1 km TT. Furthermore, physical perceptions of exertion are not clearly differentiated from the sense of effort in self-paced exercise.
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- 2014
31. Deception studies manipulating centrally acting performance modifiers: a review.
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Williams, EL, Jones, HS, Sparks, S, Marchant, DC, Micklewright, D, McNaughton, LR, Williams, EL, Jones, HS, Sparks, S, Marchant, DC, Micklewright, D, and McNaughton, LR
- Abstract
Athletes anticipatorily set and continuously adjust pacing strategies before and during events to produce optimal performance. Selfregulation ensures maximal effort is exerted in correspondence with the end point of exercise, while preventing physiological changes that are detrimental and disruptive to homeostatic control. The integration of feedforward and feedback information, together with the proposed brain_s performance modifiers is said to be fundamental to this anticipatory and continuous regulation of exercise. The manipulation of central, regulatory internal and external stimuli has been a key focus within deception research, attempting to influence the self-regulation of exercise and induce improvements in performance. Methods of manipulating performance modifiers such as unknown task end point, deceived duration or intensity feedback, self-belief, or previous experience create a challenge within research, as although they contextualize theoretical propositions, there are few ecological and practical approaches which integrate theory with practice. In addition, the different methods and measures demonstrated in manipulation studies have produced inconsistent results. This review examines and critically evaluates the current methods of how specific centrally controlled performance modifiers have been manipulated, within previous deception studies. From the 31 studies reviewed, 10 reported positive effects on performance, encouraging future investigations to explore the mechanisms responsible for influencing pacing and consequently how deceptive approaches can further facilitate performance. The review acts to discuss the use of expectation manipulation not only to examine which methods of deception are successful in facilitating performance but also to understand further the key components used in the regulation of exercise and performance.
- Published
- 2014
32. The presence of anticardiolipin antibodies in adults may be influenced by infections in infancy
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Edwards, Cj, Syddall, H, Jameson, K, Williams, El, Polosa, Riccardo, Goswami, R, Dennison, Em, Arden, Nk, Cooper, C, and HERTFORDSHIRE COHORT STUDY GROUP
- Published
- 2008
33. Physiological and Psychological Effects of Deception on Pacing Strategy and Performance: A Review
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Jones, H, Williams, EL, Bridge, CA, Marchant, D, Midgley, A, Micklewright, D, McNaughton, L, Jones, H, Williams, EL, Bridge, CA, Marchant, D, Midgley, A, Micklewright, D, and McNaughton, L
- Abstract
The aim of an optimal pacing strategy during exercise is to enhance performance whilst ensuring physiological limits are not surpassed, which has been shown to result in a metabolic reserve at the end of the exercise. There has been debate surrounding the theoretical models that have been proposed to explain how pace is regulated, with more recent research investigating a central control of exercise regulation. Deception has recently emerged as a common, practical approach to manipulate key variables during exercise. There are a number of ways in which deception interventions have been designed, each intending to gain particular insights into pacing behaviour and performance. Deception methodologies can be conceptualised according to a number of dimensions such as deception timing (prior to or during exercise), presentation frequency (blind, discontinuous or continuous) and type of deception (performance, biofeedback or environmental feedback). However, research evidence on the effects of deception has been perplexing and the use of complex designs and varied methodologies makes it difficult to draw any definitive conclusions about how pacing strategy and performance are affected by deception. This review examines existing research in the area of deception and pacing strategies, and provides a critical appraisal of the different methodological approaches used to date. It is hoped that this analysis will inform the direction and methodology of future investigations in this area by addressing the mechanisms through which deception impacts upon performance and by elucidating the potential application of deception techniques in training and competitive settings.
- Published
- 2013
34. Pullout pleaser
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Williams, El
- Abstract
I've been a reader for a while now and would just like to say thanks for your Training Notebook pullouts--they've helped me get the muscle-building results I wanted. I'm currently [...]
- Published
- 2004
35. Case report: Treatment of rocuronium-induced anaphylactic shock with vasopressin: [Presentation de cas: traitement d'un choc anaphylactique provoque par le rocuronium avec de la vasopressine].
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Meng L and Williams EL
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- 2008
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36. Replicating a community initiative for preventing adolescent pregnancy: from South Carolina to Kansas.
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Paine-Andrews A, Vincent ML, Fawcett SB, Campuzano MK, Harris KJ, Lewis RK, Williams EL, and Fisher JL
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- 1996
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37. Changes in coronary heart disease risk factors in the 1980s: evidence of a male-female crossover effect with age.
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Williams EL, Winkleby MA, and Fortmann SP
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- 1993
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38. The effect of perceived control over eating on the life satisfaction of women and men: results from a community sample.
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Greeno CG, Jackson C, Williams EL, and Fortmann SP
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OBJECTIVE: To test whether overweight, or perception of lack of control over eating, or both, contributed to the level of life satisfaction for women and men in a random sample of community-dwelling adults. METHOD: This study examined the effects of body mass index (BMI) and perceived control over eating on life satisfaction for women and men in a community-based sample of 1,069 women and 963 men. RESULTS: For women, both lack of perceived eating control and higher BMI were associated with less life satisfaction, and lack of control over eating was the more important predictor. For men, only lack of perceived eating control was associated with less life satisfaction. Furthermore, for both women and men, the contribution of eating control to life satisfaction was unaffected by BMI, that is, the life satisfaction of heavier people was not more affected by perceived control over eating than was the life satisfaction of lighter people. DISCUSSION: These findings suggest that psychological issues related to eating and weight can affect global aspects of well-being. [ABSTRACT FROM AUTHOR]
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- 1998
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39. Breastfeeding initiation among a low income multiethnic population in northern California: an exploratory study.
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Williams EL and Pan E
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Influences on the decision to initiate breastfeeding among low income mothers served by a suburban medical center in northern California were explored. Sixty-four mothers of children 0-24 months of age were interviewed in English or Spanish regarding their infant feeding education, breastfeeding attitudes and behavior, and social support. Fifty-nine percent reported having discussed infant feeding with a physician; these mothers were more likely to attempt breastfeeding than those who did not. Fifty-nine percent of the entire study population initiated breastfeeding. Initiation rates were highest for the Asian American group (86 percent), and lowest for Latinas (48 percent). Further research is needed regarding modifiable influences on breastfeeding initiation, including physician encouragement to breastfeed, for various ethnic groups. [ABSTRACT FROM AUTHOR]
- Published
- 1994
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40. Cholangiography vs Extraductal Palpation
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Rupnik Ej, Carr Re, and Williams El
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medicine.medical_specialty ,Cholangiography ,medicine.diagnostic_test ,business.industry ,Public Health, Environmental and Occupational Health ,medicine ,General Medicine ,Radiology ,business ,Palpation - Published
- 1969
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41. The management of the chronic alcoholic
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Williams El
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medicine.medical_specialty ,Alcoholism ,business.industry ,Medicine ,Alcoholism therapy ,Chronic alcoholic ,Disease Management ,Humans ,General Medicine ,Articles ,Disease management (health) ,business ,Intensive care medicine - Published
- 1954
42. Eileen Miller: the girl who spoke with pictures.
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Williams EL
- Published
- 2009
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43. Dietary intakes in people with irritable bowel syndrome
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Corfe Bernard M, Nai XuiLi, and Williams Elizabeth A
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background Irritable Bowel Syndrome (IBS) is a functional bowel disorder characterised by episodes of abdominal pain associated with altered bowel habits. Many IBS sufferers believe that diet may play a role in triggering these episodes and may avoid certain foods. However relatively few studies have undertaken a dietary assessment in IBS sufferers to examine the wider impact of the condition upon diet. Methods 104 individuals with IBS were recruited and asked to complete a validated food frequency questionnaire (FFQ). The data were analysed against Dietary Reference Values for food energy and nutrients for the United Kingdom and observed intakes for the general population and for differences between IBS subtypes and the UK population. Results The data show that the dietary intakes of this population of IBS sufferers met the UK Dietary Reference Values. The average energy intake of the population exceeded the Estimated Average Requirements of the UK population and the balance of macronutrients was favourable. Intakes of selected micronutrients significantly exceeded the reference nutrient intakes. There were no differences between IBS subtypes. Conclusions The IBS subpopulation appear to have an adequate and balanced macronutrient intake with no evidence of inadequate micronutrient intake.
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- 2011
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44. Recruiting older people to a randomised controlled dietary intervention trial - how hard can it be?
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Pockley A Graham, Parker Stuart G, Powers Hilary J, Foulds Gemma, Flower Daniel J, Saxton John M, Jones Laura, Forster Sarah E, and Williams Elizabeth A
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Medicine (General) ,R5-920 - Abstract
Abstract Background The success of a human intervention trial depends upon the ability to recruit eligible volunteers. Many trials fail because of unrealistic recruitment targets and flawed recruitment strategies. In order to predict recruitment rates accurately, researchers need information on the relative success of various recruitment strategies. Few published trials include such information and the number of participants screened or approached is not always cited. Methods This paper will describe in detail the recruitment strategies employed to identify older adults for recruitment to a 6-month randomised controlled dietary intervention trial which aimed to explore the relationship between diet and immune function (The FIT study). The number of people approached and recruited, and the reasons for exclusion, will be discussed. Results Two hundred and seventeen participants were recruited to the trial. A total of 7,482 letters were sent to potential recruits using names and addresses that had been supplied by local Family (General) Practices. Eight hundred and forty three potential recruits replied to all methods of recruitment (528 from GP letters and 315 from other methods). The eligibility of those who replied was determined using a screening telephone interview, 217 of whom were found to be suitable and agreed to take part in the study. Conclusion The study demonstrates the application of multiple recruitment methods to successfully recruit older people to a randomised controlled trial. The most successful recruitment method was by contacting potential recruits by letter on NHS headed note paper using contacts provided from General Practices. Ninety percent of recruitment was achieved using this method. Adequate recruitment is fundamental to the success of a research project, and appropriate strategies must therefore be adopted in order to identify eligible individuals and achieve recruitment targets. Trial registration number ISRCTN45031464.
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- 2010
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45. A study protocol to investigate the relationship between dietary fibre intake and fermentation, colon cell turnover, global protein acetylation and early carcinogenesis: the FACT study
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Croucher Lisa J, Riley Stuart A, Bury Jonathan P, Williams Elizabeth A, Corfe Bernard M, Lai Daphne YL, and Evans Caroline A
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background A number of studies, notably EPIC, have shown a descrease in colorectal cancer risk associated with increased fibre consumption. Whilst the underlying mechanisms are likely to be multifactorial, production of the short-chain fatty-acid butyrate fro butyratye is frequently cited as a major potential contributor to the effect. Butyrate inhibits histone deacetylases, which work on a wide range of proteins over and above histones. We therefore hypothesized that alterations in the acetylated proteome may be associated with a cancer risk phenotype in the colorectal mucosa, and that such alterations are candidate biomarkers for effectiveness of fibre interventions in cancer prevention. Methods an design There are two principal arms to this study: (i) a cross-sectional study (FACT OBS) of 90 subjects recruited from gastroenterology clinics and; (ii) an intervention trial in 40 subjects with an 8 week high fibre intervention. In both studies the principal goal is to investigate a link between fibre intake, SCFA production and global protein acetylation. The primary measure is level of faecal butyrate, which it is hoped will be elevated by moving subjects to a high fibre diet. Fibre intakes will be estimated in the cross-sectional group using the EPIC Food Frequency Questionnaire. Subsidiary measures of the effect of butyrate on colon mucosal function and pre-cancerous phenotype will include measures of apoptosis, apoptotic regulators cell cycle and cell division. Discussion This study will provide a new level of mechanistic data on alterations in the functional proteome in response to the colon microenvironment which may underwrite the observed cancer preventive effect of fibre. The study may yield novel candidate biomarkers of fibre fermentation and colon mucosal function. Trial Registration Trial Registration Number: ISRCTN90852168
- Published
- 2009
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46. Study Protocol: Randomised controlled trial to investigate the functional significance of marginal riboflavin status in young women in the UK (RIBOFEM)
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Williams Elizabeth A, Mushtaq Sohail, Hill Marilyn HE, Dainty Jack R, and Powers Hilary J
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The functional significance of moderate riboflavin deficiency as it is currently assessed is not well understood. Animal and human studies have suggested a role for riboflavin in the absorption and mobilisation of iron and as such may be important in maintaining haematological status. Recent National Diet and Nutrition Surveys in the United Kingdom have shown that young women in particular are at risk of moderate riboflavin deficiency and low iron status. Methods/Design A randomised placebo controlled intervention trial was conducted to investigate the effect of riboflavin supplementation on various measures of haematological status in a group of moderately riboflavin deficient young women aged 19 to 25 years. Women who were low milk consumers were initially screened for riboflavin status as assessed by the erythrocyte glutathione reductase activation coefficient assay (EGRAC). One hundred and twenty three women with EGRAC values >1.40 were randomised to receive 2 mg, 4 mg riboflavin or placebo for 8 weeks. In addition 36 of these women were randomly allocated to an iron bioavailability study to investigate the effect of the intervention on the absorption or utilisation of iron using an established red cell incorporation technique. Discussion One hundred and nineteen women completed the intervention study, of whom 36 completed the bioavailability arm. Compliance was 96 ± 6% (mean ± SD). The most effective recruitment strategy for this gender and age group was e-communication (e-mail and website). The results of this study will clarify the functional significance of the current biochemical deficiency threshold for riboflavin status and will inform a re-evaluation of this biochemical threshold. Trial Registration Current Controlled Trials Registration No. ISRCTN35811298
- Published
- 2009
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47. Commonly used bowel preparations have significant and different effects upon cell proliferation in the colon: a pilot study
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Riley Stuart A, Williams Elizabeth A, Bury Jonathan P, Croucher Lisa J, and Corfe Bernard M
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background Markers of crypt cell proliferation are frequently employed in studies of the impact of genetic and exogenous factors on human colonic physiology. Human studies often rely on the assessment of tissue acquired at endoscopy. Modulation of cell proliferation by bowel preparation with oral laxatives may confound the findings of such studies, but there is little data on the impact of commonly used bowel preparations on markers of cell proliferation. Methods Crypt length, crypt cellularity and crypt cell proliferation were assessed in biopsies acquired after preparation with either Klean-Prep or Picolax. Crypt cell proliferation was assessed by whole-mount mitotic figure count, and by two different immunohistochemical (IHC) labelling methods (Ki-67 and pHH3). Subsequent biopsies were obtained from the same patients without bowel preparation and similarly assessed. Parameters were compared between groups using analysis of variance and paired t-tests. Results There were significant differences in labelling indices (LI) between biopsies taken after Klean-prep and those taken after Picolax preparation, for both Ki67 (p = 0.019) and pHH3 (p = 0.017). A similar trend was seen for whole-mount mitotic figure counts. Suppression or elevation of proliferation parameters by bowel preparation may mask any effect due to an intervention or disease. Conclusion Commonly used bowel preparations may have significant and different effects on crypt cell proliferation. This should be taken into account when designing studies and when considering the findings of existing studies.
- Published
- 2008
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48. Multiple metachronous malignancies, one patient with three primary malignancies: a case report
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Fletcher Horace, Wharfe Gilian, Williams Elaine, Hanchard Barrie, and Mitchell Derek
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Medicine - Abstract
Abstract We present a 61 year old Para 4 woman who presented with stage II Infiltrating lobular carcinoma of the breast after modified radical mastectomy. She was treated with Tamoxifen for seven years. She was diagnosed with multiple myeloma during year seven post mastectomy because of wrist pain. She was treated with melphalan, prednisone and allopurinol which she tolerated well and the pain in the wrist improved. Tamoxifen was also stopped. Ten months later she presented with vaginal bleeding and was diagnosed with a poorly differentiated endometrial adenocarcinoma at hysteroscopic suction curettage and had an abdominal hysterectomy. Two years later the patient succumbed to metastatic endometrial cancer.
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- 2007
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49. PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma
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Thomas David M, Chaffer Christine L, Thompson Erik W, and Williams Elizabeth D
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Although PPARγ antagonists have shown considerable pre-clinical efficacy, recent studies suggest PPARγ ligands induce PPARγ-independent effects. There is a need to better define such effects to permit rational utilization of these agents. Methods We have studied the effects of a range of endogenous and synthetic PPARγ ligands on proliferation, growth arrest (FACS analysis) and apoptosis (caspase-3/7 activation and DNA fragmentation) in multiple prostate carcinoma cell lines (DU145, PC-3 and LNCaP) and in a series of cell lines modelling metastatic transitional cell carcinoma of the bladder (TSU-Pr1, TSU-Pr1-B1 and TSU-Pr1-B2). Results 15-deoxy-prostaglandin J2 (15dPGJ2), troglitazone (TGZ) and to a lesser extent ciglitazone exhibited inhibitory effects on cell number; the selective PPARγ antagonist GW9662 did not reverse these effects. Rosiglitazone and pioglitazone had no effect on proliferation. In addition, TGZ induced G0/G1 growth arrest whilst 15dPGJ2 induced apoptosis. Conclusion Troglitazone and 15dPGJ2 inhibit growth of prostate and bladder carcinoma cell lines through different mechanisms and the effects of both agents are PPARγ-independent.
- Published
- 2006
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50. Increasing your credibility with physicians: strategies for lactation consultants.
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Williams EL
- Published
- 1995
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