712 results on '"Williamson, Andrew"'
Search Results
2. Impact of tongue base mucosectomy on quality-of-life outcomes: systematic review and single-centre experience
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Scholfield, Daniel W., Williamson, Andrew J., Cunning, Nina, and Awad, Zaid
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- 2024
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3. Performance of artificial intelligence chatbots in sleep medicine certification board exams: ChatGPT versus Google Bard
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Cheong, Ryan Chin Taw, Pang, Kenny Peter, Unadkat, Samit, Mcneillis, Venkata, Williamson, Andrew, Joseph, Jonathan, Randhawa, Premjit, Andrews, Peter, and Paleri, Vinidh
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- 2024
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4. Artificial intelligence chatbots as sources of patient education material for obstructive sleep apnoea: ChatGPT versus Google Bard
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Cheong, Ryan Chin Taw, Unadkat, Samit, Mcneillis, Venkata, Williamson, Andrew, Joseph, Jonathan, Randhawa, Premjit, Andrews, Peter, and Paleri, Vinidh
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- 2024
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5. Phosphoproteomics predict response to midostaurin plus chemotherapy in independent cohorts of FLT3-mutated acute myeloid leukaemia
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Borek, Weronika E., Nobre, Luis, Pedicona, S. Federico, Campbell, Amy E., Christopher, Josie A., Nawaz, Nazrath, Perkins, David N., Moreno-Cardoso, Pedro, Kelsall, Janet, Ferguson, Harriet R., Patel, Bela, Gallipoli, Paolo, Arruda, Andrea, Ambinder, Alex J., Thompson, Andrew, Williamson, Andrew, Ghiaur, Gabriel, Minden, Mark D., Gribben, John G., Britton, David J., Cutillas, Pedro R., and Dokal, Arran D.
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- 2024
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6. Does non-stationary noise in LIGO and Virgo affect the estimation of $H_0$?
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Mozzon, Simone, Ashton, Gregory, Nuttall, Laura K., and Williamson, Andrew R.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,General Relativity and Quantum Cosmology - Abstract
Gravitational-wave observations of binary neutron star mergers and their electromagnetic counterparts provide an independent measurement of the Hubble constant, $H_0$, through the standard-sirens approach. Current methods of determining $H_0$, such as measurements from the early universe and the local distance ladder, are in tension with one another. If gravitational waves are to break this tension a thorough understanding of systematic uncertainty for gravitational-wave observations is required. To accurately estimate the properties of gravitational-wave signals measured by LIGO and Virgo, we need to understand the characteristics of the detectors noise. Non-gaussian transients in the detector data and rapid changes in the instrument, known as non-stationary noise, can both add a systematic uncertainty to inferred results. We investigate how non-stationary noise affects the estimation of the luminosity distance of the source, and therefore of $H_0$. Using a population of 200 simulated binary neutron star signals, we show that non-stationary noise can bias the estimation of the luminosity distance by up to 2.4\%. However, only $\sim$15\% of binary neutron star signals would be affected around their merger time with non-stationary noise at a similar level to that seen in the first half of LIGO-Virgo's third observing run. Comparing the expected bias to other systematic uncertainties, we argue that non-stationary noise in the current generation of detectors will not be a limiting factor in resolving the tension on $H_0$ using standard sirens. Although, evaluating non-stationarity in gravitational-wave data will be crucial to obtain accurate estimates of $H_0$., Comment: 10 pages, 5 figures, 1 table
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- 2021
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7. SkyPy: A package for modelling the Universe
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Amara, Adam, de la Bella, Lucia F., Birrer, Simon, Bridle, Sarah, Cordero, Juan Pablo, Favole, Ginevra, Harrison, Ian, Harry, Ian W., Hartley, William G., Krawczyk, Coleman, Lundgren, Andrew, Nord, Brian, Nuttall, Laura K., Rollins, Richard P., Sudek, Philipp, Tam, Sut-Ieng, Tessore, Nicolas, Tolley, Arthur E., Umetsu, Keiichi, Williamson, Andrew R., and Wolz, Laura
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
SkyPy is an open-source Python package for simulating the astrophysical sky. It comprises a library of physical and empirical models across a range of observables and a command-line script to run end-to-end simulations. The library provides functions that sample realisations of sources and their associated properties from probability distributions. Simulation pipelines are constructed from these models using a YAML-based configuration syntax, while task scheduling and data dependencies are handled internally and the modular design allows users to interface with external software. SkyPy is developed and maintained by a diverse community of domain experts with a focus on software sustainability and interoperability. By fostering development, it provides a framework for correlated simulations of a range of cosmological probes including galaxy populations, large scale structure, the cosmic microwave background, supernovae and gravitational waves. Version 0.4 implements functions that model various properties of galaxies including luminosity functions, redshift distributions and optical photometry from spectral energy distribution templates. Future releases will provide additional modules, for example, to simulate populations of dark matter halos and model the galaxy-halo connection, making use of existing software packages from the astrophysics community where appropriate., Comment: Published by JOSS. The package is available at https://github.com/skypyproject/skypy. Comments, issues and pull requests are welcome
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- 2021
8. Functional and quality-of-life outcomes following salvage surgery for recurrent squamous cell carcinoma of the head and neck: a systematic review and meta-analysis
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Williamson, Andrew, Jashek-Ahmed, Farizeh, Hardman, John, and Paleri, Vinidh
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- 2023
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9. Smell-related quality of life changes after total laryngectomy: a multi-centre study
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Wong, Eugene, Smith, Murray, Buchanan, Malcolm A., Kudpaje, Akshay, Williamson, Andrew, Hedge, Prasanna Suresh, Hazan, Daniel, Idaire, Jordan, Smith, Mark C., Sritharan, Niranjan, Palme, Carsten, and Riffat, Faruque
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- 2023
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10. Lightning-Fast Gravitational Wave Parameter Inference through Neural Amortization
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Delaunoy, Arnaud, Wehenkel, Antoine, Hinderer, Tanja, Nissanke, Samaya, Weniger, Christoph, Williamson, Andrew R., and Louppe, Gilles
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Astrophysics - Instrumentation and Methods for Astrophysics ,Computer Science - Machine Learning ,General Relativity and Quantum Cosmology - Abstract
Gravitational waves from compact binaries measured by the LIGO and Virgo detectors are routinely analyzed using Markov Chain Monte Carlo sampling algorithms. Because the evaluation of the likelihood function requires evaluating millions of waveform models that link between signal shapes and the source parameters, running Markov chains until convergence is typically expensive and requires days of computation. In this extended abstract, we provide a proof of concept that demonstrates how the latest advances in neural simulation-based inference can speed up the inference time by up to three orders of magnitude -- from days to minutes -- without impairing the performance. Our approach is based on a convolutional neural network modeling the likelihood-to-evidence ratio and entirely amortizes the computation of the posterior. We find that our model correctly estimates credible intervals for the parameters of simulated gravitational waves., Comment: V1: First version; V2: Updated references; V3: Update references and camera-ready version; V4: Correct figure labels; V5: Updated references
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- 2020
11. The role of diabetes in metastatic melanoma patients treated with nivolumab plus relatlimab
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Mallardo, Domenico, Woodford, Rachel, Menzies, Alexander M., Zimmer, Lisa, williamson, Andrew, Ramelyte, Egle, Dimitriou, Florentia, Wicky, Alexandre, Wallace, Roslyn, Mallardo, Mario, Cortellini, Alessio, Budillon, Alfredo, Atkinson, Victoria, Sandhu, Shahneen, Olivier, Michielin, Dummer, Reinhard, Lorigan, Paul, Schadendorf, Dirk, Long, Georgina V., Simeone, Ester, and Ascierto, Paolo A.
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- 2023
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12. Transoral robotic surgery without adjuvant therapy: A systematic review and meta-analysis of the association between surgical margins and local recurrence
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Williamson, Andrew, Moen, Christy M., Slim, Mohd Afiq Mohd, Warner, Laura, O'Leary, Ben, and Paleri, Vinidh
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- 2023
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13. Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective cohort study
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Bai, Xue, Shaheen, Ahmed, Grieco, Charlotte, d’Arienzo, Paolo D., Mina, Florentia, Czapla, Juliane A., Lawless, Aleigha R., Bongiovanni, Eleonora, Santaniello, Umberto, Zappi, Helena, Dulak, Dominika, Williamson, Andrew, Lee, Rebecca, Gupta, Avinash, Li, Caili, Si, Lu, Ubaldi, Martina, Yamazaki, Naoya, Ogata, Dai, Johnson, Rebecca, Park, Benjamin C., Jung, Seungyeon, Madonna, Gabriele, Hochherz, Juliane, Umeda, Yoshiyasu, Nakamura, Yasuhiro, Gebhardt, Christoffer, Festino, Lucia, Capone, Mariaelena, Ascierto, Paolo Antonio, Johnson, Douglas B., Lo, Serigne N., Long, Georgina V., Menzies, Alexander M., Namikawa, Kenjiro, Mandala, Mario, Guo, Jun, Lorigan, Paul, Najjar, Yana G., Haydon, Andrew, Quaglino, Pietro, Boland, Genevieve M., Sullivan, Ryan J., Furness, Andrew J.S., Plummer, Ruth, and Flaherty, Keith T.
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- 2023
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14. Crossing Campus Boundaries: Using Classical Mythology and Digital Storytelling to Connect Honors Colleges
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Navarre, Joan, Kayser, Maddie, Pass, Dylan, Bisch, Marilyn, Smith, Catherine, and Williamson, Andrew
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In spring 2018, two honors colleges--Indiana State University (ISU) and University of Wisconsin-Stout (UW-Stout)--came together to create a cross-institutional collaboration blurring the boundaries between campuses. This project connected first-year honors students with the core curriculum of two geographically separated honors colleges. Building on their studies of Classical mythology, ISU honors students in Classical Cultures of Greece and Rome reviewed, advised, and critiqued screenplays composed by UW-Stout students in Honors English, leading to the production of short films presented at ISU's "Spring Classics Fest" and UW-Stout's "4:51 Short Film Festival and Exhibition." Drawing on our NCHC 2018 panel presentation in Boston, this illustrated paper highlights the value of cross-institutional collaborations for honors students, teachers, and programs. The collaborative process advanced skills in critical reading, analysis, and writing; engaged students and teachers in the scholarship of teaching and learning; and contributed to curricular innovation. Examples of assignments, interim results, and student-created short films are featured along with students' assessments of the value of crossing campus boundaries.
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- 2019
15. Localization of Binary Black-Hole Mergers with Known Inclination
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Corley, K. Rainer, Bartos, Imre, Singer, Leo P., Williamson, Andrew R., Haiman, Zoltan, Kocsis, Bence, Nissanke, Samaya, Marka, Zsuzsa, and Marka, Szabolcs
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The localization of stellar-mass binary black hole mergers using gravitational waves is critical in understanding the properties of the binaries' host galaxies, observing possible electromagnetic emission from the mergers, or using them as a cosmological distance ladder. The precision of this localization can be substantially increased with prior astrophysical information about the binary system. In particular, constraining the inclination of the binary can reduce the distance uncertainty of the source. Here we present the first realistic set of localizations for binary black hole mergers, including different prior constraints on the binaries' inclinations. We find that prior information on the inclination can reduce the localization volume by a factor of 3. We discuss two astrophysical scenarios of interest: (i) follow-up searches for beamed electromagnetic/neutrino counterparts and (ii) mergers in the accretion disks of active galactic nuclei., Comment: Accepted for publication in MNRAS; 5 pages, 2 figures
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- 2019
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16. The experience of patients with lung cancer during the COVID-19 pandemic and its importance for post-pandemic outpatient cancer care planning: A cross sectional study exploring the roles of age and frailty
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Gomes, Fabio, Taylor, Sally, Scanlon, Lauren, Coombermoore, Jake, Eastwood, Charlotte, Stanworth, Melissa, Williamson, Andrew, Barnes, Claire, and Yorke, Janelle
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- 2023
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17. HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block
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Maiques-Diaz, Alba, Nicosia, Luciano, Basma, Naseer J., Romero-Camarero, Isabel, Camera, Francesco, Spencer, Gary J., Amaral, Fabio M. R., Simeoni, Fabrizio, Wingelhofer, Bettina, Williamson, Andrew J. K., Pierce, Andrew, Whetton, Anthony D., and Somervaille, Tim C. P.
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- 2022
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18. Gravitational waveforms from SpEC simulations : neutron star-neutron star and low-mass black hole-neutron star binaries
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Foucart, Francois, Duez, Matthew D., Hinderer, Tanja, Caro, Jesus, Williamson, Andrew R., Boyle, Michael, Buonanno, Alessandra, Haas, Roland, Hemberger, Daniel A., Kidder, Lawrence E., Pfeiffer, Harald P., and Scheel, Mark A.
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Gravitational waveforms from numerical simulations are a critical tool to test and analytically calibrate the waveform models used to study the properties of merging compact objects. In this paper, we present a series of high-accuracy waveforms produced with the SpEC code for systems involving at least one neutron star. We provide for the first time waveforms with sub-radian accuracy over more than twenty cycles for low-mass black hole-neutron star binaries, including binaries with non-spinning objects, and binaries with rapidly spinning neutron stars that maximize the impact on the gravitational wave signal of the near-resonant growth of the fundamental excitation mode of the neutron star (f-mode). We also provide for the first time with SpEC a high-accuracy neutron star-neutron star waveform. These waveforms are made publicly available as part of the SxS catalogue. We compare our results to analytical waveform models currently implemented in data analysis pipelines. For most simulations, the models lie outside of the predicted numerical errors in the last few orbits before merger, but do not show systematic deviations from the numerical results: comparing different models appears to provide reasonable estimates of the modeling errors. The sole exception is the equal-mass simulation using a rapidly counter-rotating neutron star to maximize the impact of the excitation of the f-mode, for which all models perform poorly. This is however expected, as even the single model that takes f-mode excitation into account ignores the significant impact of the neutron star spin on the f-mode excitation frequency., Comment: 17p, 10 figures
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- 2018
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19. Unbiased Hubble constant estimation from binary neutron star mergers
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Mortlock, Daniel J., Feeney, Stephen M., Peiris, Hiranya V., Williamson, Andrew R., and Nissanke, Samaya M.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Gravitational wave (GW) observations of binary neutron star (BNS) mergers can be used to measure luminosity distances and hence, when coupled with estimates for the mergers' host redshifts, infer the Hubble constant, $H_0$. These observations are, however, affected by GW measurement noise, uncertainties in host redshifts and peculiar velocities, and are potentially biased by selection effects and the mis-specification of the cosmological model or the BNS population. The estimation of $H_0$ from samples of BNS mergers with optical counterparts is tested here by using a phenomenological model for the GW strains that captures both the data-driven event selection and the distance-inclination degeneracy, while being simple enough to facilitate large numbers of simulations. A rigorous Bayesian approach to analyzing the data from such simulated BNS merger samples is shown to yield results that are unbiased, have the appropriate uncertainties, and are robust to model mis-specification. Applying such methods to a sample of $N \simeq 50$ BNS merger events, as LIGO+Virgo could produce in the next $\sim 5$ years, should yield robust and accurate Hubble constant estimates that are precise to a level of $\sim 2$ km s$^{-1}$ Mpc$^{-1}$, sufficient to reliably resolve the current tension between local and cosmological measurements of $H_0$., Comment: 21 pages (including eight-page appendices); 9 figures. Matches version accepted by PRD
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- 2018
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20. On the Origin of the Two-Dimensional Electron Gas at the CdO (100) Surface
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Clark, Pip C. J., Williamson, Andrew I., Lewis, Nathan K., Ahumada-Lazo, Ruben, Silly, Mathieu, Mudd, James J., McConville, Chris F., and Flavell, Wendy R.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Synchrotron-radiation angle-resolved and core-level photoemission spectroscopy are used together to investigate the origin of the two-dimensional electron gas on the surface of single crystal CdO (100) films. A reduction in the two-dimensional electron density of the surface state is observed under the synchrotron beam during ARPES, which is shown to be accompanied by a concomitant reduction in the surface-adsorbed species (monitored through the O 1s core level signal). This shows that surface adsorbates donate electrons into the surface accumulation layer. When the surface is cleaned, the surface conduction band state empties. A surface doped with atomic H is also studied. Here, interstitial H increases the two-dimensional electron density at the surface. This demonstrates that reversible donor doping is possible. The surface band bending profiles, 2D electron densities, and effective masses are calculated from subband dispersion simulations., Comment: 8 pages, 6 figures
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- 2018
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21. Distinguishing the nature of comparable-mass neutron star binary systems with multimessenger observations: GW170817 case study
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Hinderer, Tanja, Nissanke, Samaya, Foucart, Francois, Hotokezaka, Kenta, Vincent, Trevor, Kasliwal, Mansi, Schmidt, Patricia, Williamson, Andrew R., Nichols, David, Duez, Matthew, Kidder, Lawrence E., Pfeiffer, Harald P., and Scheel, Mark A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The discovery of GW170817 with gravitational waves (GWs) and electromagnetic (EM) radiation is prompting new questions in strong-gravity astrophysics. Importantly, it remains unknown whether the progenitor of the merger comprised two neutron stars (NSs), or a NS and a black hole (BH). Using new numerical-relativity simulations and incorporating modeling uncertainties we produce novel GW and EM observables for NS-BH mergers with similar masses. A joint analysis of GW and EM measurements reveals that if GW170817 is a NS-BH merger, <40% of the binary parameters consistent with the GW data are compatible with EM observations., Comment: 8 pages
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- 2018
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22. Black holes, gravitational waves and fundamental physics: a roadmap
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Barack, Leor, Cardoso, Vitor, Nissanke, Samaya, Sotiriou, Thomas P., Askar, Abbas, Belczynski, Krzysztof, Bertone, Gianfranco, Bon, Edi, Blas, Diego, Brito, Richard, Bulik, Tomasz, Burrage, Clare, Byrnes, Christian T., Caprini, Chiara, Chernyakova, Masha, Chrusciel, Piotr, Colpi, Monica, Ferrari, Valeria, Gaggero, Daniele, Gair, Jonathan, Garcia-Bellido, Juan, Hassan, S. F., Heisenberg, Lavinia, Hendry, Martin, Heng, Ik Siong, Herdeiro, Carlos, Hinderer, Tanja, Horesh, Assaf, Kavanagh, Bradley J., Kocsis, Bence, Kramer, Michael, Tiec, Alexandre Le, Mingarelli, Chiara, Nardini, Germano, Nelemans, Gijs, Palenzuela, Carlos, Pani, Paolo, Perego, Albino, Porter, Edward K., Rossi, Elena M., Schmidt, Patricia, Sesana, Alberto, Sperhake, Ulrich, Stamerra, Antonio, Stein, Leo C., Tamanini, Nicola, Tauris, Thomas M., Urena-Lopez, L. Arturo, Vincent, Frederic, Volonteri, Marta, Wardell, Barry, Wex, Norbert, Yagi, Kent, Abdelsalhin, Tiziano, Aloy, Miguel Angel, Amaro-Seoane, Pau, Annulli, Lorenzo, Arca-Sedda, Manuel, Bah, Ibrahima, Barausse, Enrico, Barakovic, Elvis, Benkel, Robert, Bennett, Charles L., Bernard, Laura, Bernuzzi, Sebastiano, Berry, Christopher P. L., Berti, Emanuele, Bezares, Miguel, Blanco-Pillado, Jose Juan, Blazquez-Salcedo, Jose Luis, Bonetti, Matteo, Boskovic, Mateja, Bosnjak, Zeljka, Bricman, Katja, Bruegmann, Bernd, Capelo, Pedro R., Carloni, Sante, Cerda-Duran, Pablo, Charmousis, Christos, Chaty, Sylvain, Clerici, Aurora, Coates, Andrew, Colleoni, Marta, Collodel, Lucas G., Compere, Geoffrey, Cook, William, Cordero-Carrion, Isabel, Correia, Miguel, de la Cruz-Dombriz, Alvaro, Czinner, Viktor G., Destounis, Kyriakos, Dialektopoulos, Kostas, Doneva, Daniela, Dotti, Massimo, Drew, Amelia, Eckner, Christopher, Edholm, James, Emparan, Roberto, Erdem, Recai, Ferreira, Miguel, Ferreira, Pedro G., Finch, Andrew, Font, Jose A., Franchini, Nicola, Fransen, Kwinten, Gal'tsov, Dmitry, Ganguly, Apratim, Gerosa, Davide, Glampedakis, Kostas, Gomboc, Andreja, Goobar, Ariel, Gualtieri, Leonardo, Guendelman, Eduardo, Haardt, Francesco, Harmark, Troels, Hejda, Filip, Hertog, Thomas, Hopper, Seth, Husa, Sascha, Ihanec, Nada, Ikeda, Taishi, Jaodand, Amruta, Jimenez-Forteza, Philippe Jetzer Xisco, Kamionkowski, Marc, Kaplan, David E., Kazantzidis, Stelios, Kimura, Masashi, Kobayashi, Shiho, Kokkotas, Kostas, Krolik, Julian, Kunz, Jutta, Lammerzahl, Claus, Lasky, Paul, Lemos, Jose P. S., Said, Jackson Levi, Liberati, Stefano, Lopes, Jorge, Luna, Raimon, Ma, Yin-Zhe, Maggio, Elisa, Montero, Marina Martinez, Maselli, Andrea, Mayer, Lucio, Mazumdar, Anupam, Messenger, Christopher, Menard, Brice, Minamitsuji, Masato, Moore, Christopher J., Mota, David, Nampalliwar, Sourabh, Nerozzi, Andrea, Nichols, David, Nissimov, Emil, Obergaulinger, Martin, Obers, Niels A., Oliveri, Roberto, Pappas, George, Pasic, Vedad, Peiris, Hiranya, Petrushevska, Tanja, Pollney, Denis, Pratten, Geraint, Rakic, Nemanja, Racz, Istvan, Radia, Miren, Ramazanouglu, Fethi M., Ramos-Buades, Antoni, Raposo, Guilherme, Rosca-Mead, Roxana, Rogatko, Marek, Rosinska, Dorota, Rosswog, Stephan, Morales, Ester Ruiz, Sakellariadou, Mairi, Sanchis-Gual, Nicolas, Salafia, Om Sharan, Samajdar, Anuradha, Sintes, Alicia, Smole, Majda, Sopuerta, Carlos, Souza-Lima, Rafael, Stalevski, Marko, Stergioulas, Nikolaos, Stevens, Chris, Tamfal, Tomas, Torres-Forne, Alejandro, Tsygankov, Sergey, Unluturk, Kivanc, Valiante, Rosa, van de Meent, Maarten, Velhinho, Jose, Verbin, Yosef, Vercnocke, Bert, Vernieri, Daniele, Vicente, Rodrigo, Vitagliano, Vincenzo, Weltman, Amanda, Whiting, Bernard, Williamson, Andrew, Witek, Helvi, Wojnar, Aneta, Yakut, Kadri, Yan, Haopeng, Yazadjiev, Stoycho, Zaharijas, Gabrijela, and Zilhao, Miguel
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Theory - Abstract
The grand challenges of contemporary fundamental physics---dark matter, dark energy, vacuum energy, inflation and early universe cosmology, singularities and the hierarchy problem---all involve gravity as a key component. And of all gravitational phenomena, black holes stand out in their elegant simplicity, while harbouring some of the most remarkable predictions of General Relativity: event horizons, singularities and ergoregions. The hitherto invisible landscape of the gravitational Universe is being unveiled before our eyes: the historical direct detection of gravitational waves by the LIGO-Virgo collaboration marks the dawn of a new era of scientific exploration. Gravitational-wave astronomy will allow us to test models of black hole formation, growth and evolution, as well as models of gravitational-wave generation and propagation. It will provide evidence for event horizons and ergoregions, test the theory of General Relativity itself, and may reveal the existence of new fundamental fields. The synthesis of these results has the potential to radically reshape our understanding of the cosmos and of the laws of Nature. The purpose of this work is to present a concise, yet comprehensive overview of the state of the art in the relevant fields of research, summarize important open problems, and lay out a roadmap for future progress., Comment: White Paper for the COST action "Gravitational Waves, Black Holes, and Fundamental Physics", 272 pages, 12 figures; v4: updated references and author list. Overall improvements and corrections. To appear in Classical and Quantum Gravity
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- 2018
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23. Prospects for resolving the Hubble constant tension with standard sirens
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Feeney, Stephen M., Peiris, Hiranya V., Williamson, Andrew R., Nissanke, Samaya M., Mortlock, Daniel J., Alsing, Justin, and Scolnic, Dan
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Hubble constant ($H_0$) estimated from the local Cepheid-supernova (SN) distance ladder is in 3-$\sigma$ tension with the value extrapolated from cosmic microwave background (CMB) data assuming the standard cosmological model. Whether this tension represents new physics or systematic effects is the subject of intense debate. Here, we investigate how new, independent $H_0$ estimates can arbitrate this tension, assessing whether the measurements are consistent with being derived from the same model using the posterior predictive distribution (PPD). We show that, with existing data, the inverse distance ladder formed from BOSS baryon acoustic oscillation measurements and the Pantheon SN sample yields an $H_0$ posterior near-identical to the Planck CMB measurement. The observed local distance ladder value is a very unlikely draw from the resulting PPD. Turning to the future, we find that a sample of $\sim50$ binary neutron star "standard sirens" (detectable within the next decade) will be able to adjudicate between the local and CMB estimates., Comment: Eight pages, four figures. v3: matches version accepted by Physical Review Letters. Code available at https://github.com/sfeeney/hh0
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- 2018
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24. Paediatric tracheobronchomalacia: Incidence, patient characteristics, and predictors of surgical intervention
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Williamson, Andrew, Young, David, and Clement, William Andrew
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- 2022
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25. A counterexample to De Pierro's conjecture on the convergence of under-relaxed cyclic projections
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Cominetti, Roberto, Roshchina, Vera, and Williamson, Andrew
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Mathematics - Optimization and Control - Abstract
The convex feasibility problem consists in finding a point in the intersection of a finite family of closed convex sets. When the intersection is empty, a best compromise is to search for a point that minimizes the sum of the squared distances to the sets. In 2001, de Pierro conjectured that the limit cycles generated by the $\varepsilon$-under-relaxed cyclic projection method converge when $\varepsilon\downarrow 0$ towards a least squares solution. While the conjecture has been confirmed under fairly general conditions, we show that it is false in general by constructing a system of three compact convex sets in $\mathbb{R}^3$ for which the $\varepsilon$-under-relaxed cycles do not converge.
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- 2018
26. Targeted numerical simulations of binary black holes for GW170104
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Healy, James, Lange, Jacob, O'Shaughnessy, Richard, Lousto, Carlos, Campanelli, Manuela, Williamson, Andrew, Zlochower, Yosef, Bustillo, Juan Calderon, Clark, James, Evans, Christopher, Ferguson, D., Ghonge, Sudarshan, Jani, Karan, Khamesra, Bhavesh, Laguna, Pablo, Shoemaker, Deirdre M., Garcia, Alyssa, Boyle, Michael, Hemberger, Daniel, Kidder, Lawrence, Kumar, Prayush, Lovelace, Geoffrey, Pfeiffer, Harald, Scheel, Mark, and Teukolsky, Saul
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General Relativity and Quantum Cosmology ,Astrophysics - Astrophysics of Galaxies - Abstract
In response to LIGO's observation of GW170104, we performed a series of full numerical simulations of binary black holes, each designed to replicate likely realizations of its dynamics and radiation. These simulations have been performed at multiple resolutions and with two independent techniques to solve Einstein's equations. For the nonprecessing and precessing simulations, we demonstrate the two techniques agree mode by mode, at a precision substantially in excess of statistical uncertainties in current LIGO's observations. Conversely, we demonstrate our full numerical solutions contain information which is not accurately captured with the approximate phenomenological models commonly used to infer compact binary parameters. To quantify the impact of these differences on parameter inference for GW170104 specifically, we compare the predictions of our simulations and these approximate models to LIGO's observations of GW170104., Comment: 11 figures, 20 pages
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- 2017
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27. Constraints On Short, Hard Gamma-Ray Burst Beaming Angles From Gravitational Wave Observations
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Williams, Daniel, Clark, James A., Williamson, Andrew R., and Heng, Ik Siong
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Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology - Abstract
The first detection of a binary neutron star merger, GW170817, and an associated short gamma-ray burst confirmed that neutron star mergers are responsible for at least some of these bursts. The prompt gamma ray emission from these events is thought to be highly relativistically beamed. We present a method for inferring limits on the extent of this beaming by comparing the number of short gamma-ray bursts observed electromagnetically to the number of neutron star binary mergers detected in gravitational waves. We demonstrate that an observing run comparable to the expected Advanced LIGO 2016--2017 run would be capable of placing limits on the beaming angle of approximately $\theta \in (2.88^\circ,14.15^\circ)$, given one binary neutron star detection. We anticipate that after a year of observations with Advanced LIGO at design sensitivity in 2020 these constraints would improve to $\theta \in (8.10^\circ,14.95^\circ)$., Comment: 11 pages with 10 figures
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- 2017
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28. Correction: Smell-related quality of life changes after total laryngectomy: a multi-centre study
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Wong, Eugene, Smith, Murray, Buchanan, Malcolm A., Kudpaje, Akshay, Williamson, Andrew, Hedge, Prasanna Suresh, Hazan, Daniel, Idiare, Jordan, Smith, Mark C., Sritharan, Niranjan, Palme, Carsten, and Riffat, Faruque
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- 2023
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29. Forensic Intelligence
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Williamson, Andrew, Roycroft, Mark, editor, and Brine, Lindsey, editor
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- 2021
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30. Multi-drug algorithm to accurately predict best first-line treatments in newly-diagnosed acute myeloid leukemia (AML).
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Rodriguez Cutillas, Pedro, primary, Borek, Weronika E., additional, Christopher, Josie A., additional, Nobre, Luis Veiga, additional, Campbell, Amy, additional, Kelsall, Janet, additional, Pedicona, Federico, additional, Nawaz, Nazrath, additional, Perkins, David N., additional, Cardoso, Pedro Moreno, additional, Arruda, Andrea, additional, Ambinder, Alexander Joseph, additional, Dutta, Sayantanee, additional, Gallipoli, Paolo, additional, Sill, Heinz, additional, Ghiaur, Gabriel, additional, Minden, Mark D., additional, Williamson, Andrew, additional, Gribben, John G., additional, and Dokal, Arran David, additional
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- 2024
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31. Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective cohort study
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Bai, Xue, primary, Shaheen, Ahmed, additional, Grieco, Charlotte, additional, d’Arienzo, Paolo D., additional, Mina, Florentia, additional, Czapla, Juliane A., additional, Lawless, Aleigha R., additional, Bongiovanni, Eleonora, additional, Santaniello, Umberto, additional, Zappi, Helena, additional, Dulak, Dominika, additional, Williamson, Andrew, additional, Lee, Rebecca, additional, Gupta, Avinash, additional, Li, Caili, additional, Si, Lu, additional, Ubaldi, Martina, additional, Yamazaki, Naoya, additional, Ogata, Dai, additional, Johnson, Rebecca, additional, Park, Benjamin C., additional, Jung, Seungyeon, additional, Madonna, Gabriele, additional, Hochherz, Juliane, additional, Umeda, Yoshiyasu, additional, Nakamura, Yasuhiro, additional, Gebhardt, Christoffer, additional, Festino, Lucia, additional, Capone, Mariaelena, additional, Ascierto, Paolo Antonio, additional, Johnson, Douglas B., additional, Lo, Serigne N., additional, Long, Georgina V., additional, Menzies, Alexander M., additional, Namikawa, Kenjiro, additional, Mandala, Mario, additional, Guo, Jun, additional, Lorigan, Paul, additional, Najjar, Yana G., additional, Haydon, Andrew, additional, Quaglino, Pietro, additional, Boland, Genevieve M., additional, Sullivan, Ryan J., additional, Furness, Andrew J.S., additional, Plummer, Ruth, additional, and Flaherty, Keith T., additional
- Published
- 2024
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32. Remote sensing of rapidly draining supraglacial lakes on the Greenland Ice Sheet
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Williamson, Andrew Graham, Arnold, Neil, Willis, Ian, and Banwell, Alison
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551.31 ,glaciology ,ice-sheet hydrology ,ice sheet ,Greenland Ice Sheet ,Greenland ,rapid lake drainage ,remote sensing ,hydrofracture ,supraglacial hydrology ,hydrology ,MODIS ,Landsat 8 ,Sentinel-2 ,FAST algorithm ,FASTER algorithm ,Paakitsoq ,Store Glacier ,West Greenland ,Exploratory Data Analysis - Abstract
Supraglacial lakes in the ablation zone of the Greenland Ice Sheet (GrIS) often drain rapidly (in hours to days) by hydraulically-driven fracture (“hydrofracture”) in the summer. Hydrofracture can deliver large meltwater volumes to the ice-bed interface and open-up surface-to-bed connections, thereby routing surface meltwater to the subglacial system, altering basal water pressures and, consequently, the velocity profile of the GrIS. The study of rapidly draining lakes is thus important for developing coupled hydrology and ice-dynamics models, which can help predict the GrIS’s future mass balance. Remote sensing is commonly used to identify the location, timing and magnitude of rapid lake-drainage events for different regions of the GrIS and, with the increased availability of high-quality satellite data, may be able to offer additional insights into the GrIS’s surface hydrology. This study uses new remote-sensing datasets and develops novel analytical techniques to produce improved knowledge of rapidly draining lake behaviour in west Greenland over recent years. While many studies use 250 m MODerate-resolution Imaging Spectroradiometer (MODIS) imagery to monitor intra- and inter-annual changes to lakes on the GrIS, no existing research with MODIS calculates changes to individual and total lake volume using a physically-based method. The first aim of this research is to overcome this shortfall by developing a fully-automated lake area and volume tracking method (“the FAST algorithm”). For this, various methods for automatically calculating lake areas and volumes with MODIS are tested, and the best techniques are incorporated into the FAST algorithm. The FAST algorithm is applied to the land-terminating Paakitsoq and marine-terminating Store Glacier regions of west Greenland to investigate the incidence of rapid lake drainage in summer 2014. The validation and application of the FAST algorithm show that lake areas and volumes (using a physically-based method) can be calculated accurately using MODIS, that the new algorithm can identify rapidly draining lakes reliably, and that it therefore has the potential to be used widely across the GrIS to generate novel insights into rapidly draining lakes. The controls on rapid lake drainage remain unclear, making it difficult to incorporate lake drainage into models of GrIS hydrology. The second aspect of this study therefore investigates whether various hydrological, morphological, glaciological and surface-mass-balance controls can explain the incidence of rapid lake drainage on the GrIS. These potential controlling factors are examined within an Exploratory Data Analysis statistical technique to elicit statistical similarities and differences between the rapidly and non-rapidly draining lake types. The results show that the lake types are statistically indistinguishable for almost all factors, except lake area. It is impossible, therefore, to elicit an empirically-supported, deterministic method for predicting hydrofracture in models of GrIS hydrology. A frequent problem in remote sensing is the need to trade-off high spatial resolution for low temporal resolution, or vice versa. The final element of this thesis overcomes this problem in the context of monitoring lakes on the GrIS by adapting the FAST algorithm (to become “the FASTER algorithm”) to use with a combined Landsat 8 and Sentinel-2 satellite dataset. The FASTER algorithm is applied to a large, predominantly land-terminating region of west Greenland in summers 2016 and 2017 to track changes to lakes, identify rapidly draining lakes, and ascertain the extra quantity of information that can be generated by using the two satellites simultaneously rather than individually. The FASTER algorithm can monitor changes to lakes at both high spatial (10 to 30 m) and temporal (~3 days) resolution, overcoming the limitation of low spatial or temporal resolution associated with previous remote sensing of lakes on the GrIS. The combined dataset identifies many additional rapid lake-drainage events than would be possible with Landsat 8 or Sentinel-2 alone, due to their low temporal resolutions, or with MODIS, due to its inferior spatial resolution.
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- 2018
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33. Anatomy and Physiology of Head and Neck Endocrine Glands
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Williamson, Andrew, primary
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- 2022
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34. Carrier dynamics, persistent photoconductivity and defect chemistry at zinc oxide photoanodes
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Williamson, Andrew and Flavell, Wendy
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500 ,XPS ,Surface science ,Photovoltaics ,ZnO - Abstract
Zinc oxide (ZnO) is a promising photoanode material which has been used in quantum dot-based depleted heterojunction solar cells. The specific influence of the defect chemistry of ZnO on its n-type conductivity remains a focus for research. This thesis presents results from a series of near-ambient pressure (NAP) XPS experiments (at The University of Manchester, UK), used to characterise surface adsorption of O2 and H2O on ZnO(10-10) surfaces in high pressure environments. Water dosing is shown to lead to surface hydroxylation and a change in the surface band bending consistent with an increase in the surface conductivity. Oxygen dosing is also observed to lead to the formation of surface species on the ZnO surface, revealing that ZnO is prone to hydroxylation even in oxygen-rich environments. The role of surface OH on influencing the transient surface photovoltage (SPV) of the ZnO(10-10) surface is probed through a series of time-resolved, pump-probe XPS experiments (at SOLEIL synchrotron, France). It is shown that increasing the degree of surface hydroxylation leads to a decrease in surface band bending, leading to longer-lived transient SPV. Other factors influencing the SPV dynamics are explored, such as the role of the oxygen vacancy concentration. The transient SPV decay lifetime is shown to increase with increasing oxygen vacancy concentration, consistent with the presence of persistent photoconductivity (PPC) in ZnO, mediated by oxygen vacancy-related hole traps. The influence of the concentration of thermally excited carriers in ZnO on the surface band bending is also described, showing that the equilibrium band bending and the surface photovoltage are both reduced at low temperature. It is shown that thermal excitation of carriers from the valence band of ZnO and from neutral oxygen vacancies have negligible influence on the magnitude of equilibrium band bending at the surface. The energy regime consistent with the observed temperature dependence is also consistent with a perturbed-host state 0.2 eV below the conduction band minimum. This meta-stable state is associated with doubly-ionised oxygen vacancies, that mediate the PPC in ZnO. However this does not rule out the contribution from other shallow donor levels such as those associated with hydrogen impurities. The influence of hydrogen on the SPV dynamics in ZnO is explored, through angle-resolved photoemission spectroscopy (ARPES) after implanting hydrogen atoms into the ZnO surface. H implantation is shown to lead to the formation of a 2D electron gas (2DEG) at the surface, consistent with an increase in conductivity at the surface large enough to change the nature of the space-charge region at the ZnO surface from depletion to accumulation.
- Published
- 2017
35. The use of pembrolizumab monotherapy for the management of head and neck squamous cell carcinoma (HNSCC) in the UK.
- Author
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Vasiliadou, Ifigenia, Grose, Derek, Wilson, Christina, Thapa, Alekh, Donnelly, Olly, Lee, Elsa, Leslie, Isla, Karim, Mahwish, Hartley, Andrew, Partridge, Sarah, Medlow, Katharine, De Boisanger, James, Metcalf, Robert, Williamson, Andrew, Haridass, Anoop, Noble, David, Mactier, Karen, Walter, Harriet, Ma, Ning, and De Winton, Emma
- Subjects
SQUAMOUS cell carcinoma ,DRUG side effects ,PEMBROLIZUMAB ,OVERALL survival ,PROGRESSION-free survival - Abstract
Pembrolizumab has received approval in the UK as first‐line monotherapy for recurrent and/or metastatic HNSCC (R/M HNSCC) following the results of the KEYNOTE‐048 trial, which demonstrated a longer overall survival (OS) in comparison to the EXTREME chemotherapy regimen in patients with a combined positive score (CPS) ≥1. In this article, we provide retrospective real‐world data on the role of pembrolizumab monotherapy as first‐line systemic therapy for HNSCC across 18 centers in the UK from March 20, 2020 to May 31, 2021. 211 patients were included, and in the efficacy analysis, the objective response rate (ORR) was 24.7%, the median progression‐free survival (PFS) was 4.8 months (95% confidence interval [CI]: 3.6–6.1), and the median OS was 10.8 months (95% CI 9.0–12.5). Pembrolizumab monotherapy was well tolerated, with 18 patients having to stop treatment owing to immune‐related adverse events (irAEs). 53 patients proceeded to second‐line treatment with a median PFS2 of 10.2 months (95% CI: 8.8–11.5). Moreover, patients with documented irAEs had a statistically significant longer median PFS (11.3 vs. 3.3 months; log‐rank p value = <.001) and median OS (18.8 vs. 8.9 months; log‐rank p value <.001). The efficacy and safety of pembrolizumab first‐line monotherapy for HNSCC has been validated using real‐world data. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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36. Survival outcomes in head and neck squamous cell carcinoma of unknown primary: A national cohort study.
- Author
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Hardman, John C., Constable, James, Dobbs, Sian, Hogan, Christopher, Hulse, Kate, Khosla, Shivun, Milinis, Kristijonas, Tudor‐Green, Ben, Williamson, Andrew, Paleri, Vinidh, Asimakopoulos, Panagiotis, Cooper, Fergus, Rao, Prerana, Davies, Katharine, Davies, Timothy, Derbyshire, Stephen, Gao, Chuanyu, Ike, Chiugo, Abdelkader, Maged, and Spraggs, Paul
- Subjects
HUMAN papillomavirus ,SQUAMOUS cell carcinoma ,SURVIVAL rate ,OVERALL survival ,METASTASIS - Abstract
Introduction: To investigate factors influencing survival in head and neck squamous cell carcinoma of unknown primary (HNSCCUP). Methods: A retrospective observational cohort study was conducted, over 5 years from January 2015, in UK Head and Neck centres, of consecutive adults undergoing 18F‐Fluorodeoxyglucose‐PET‐CT within 3 months of diagnosis with metastatic cervical squamous cell carcinoma. Patients treated as HNSCCUP underwent survival analysis, stratified by neck dissection and/or radiotherapy to the ipsilateral neck, and by HPV status. Results: Data were received from 57 centres for 965 patients, of whom 482 started treatment for HNSCCUP (65.7% HPV‐positive, n = 282/429). Five‐year overall survival (OS) for HPV‐positive patients was 85.0% (95% CI 78.4–92.3) and 43.5% (95% CI 32.9–57.5) for HPV‐negative. HPV‐negative status was associated with worse OS, disease‐free (DFS), and disease‐specific (DSS) survival (all p <.0001 on log‐rank test) but not local control (LC) (p =.16). Unilateral HPV‐positive disease treated with surgery alone was associated with significantly worse DFS (p <.0001) and LC (p <.0001) compared to radiotherapy alone or combined modalities (5‐year DFS: 24.9%, 82.3% and 94.3%; 5‐year LC: 41.8%, 98.8% and 98.6%). OS was not significantly different (p =.16). Unilateral HPV‐negative disease treated with surgery alone was associated with significantly worse LC (p =.017) (5‐year LC: estimate unavailable, 93.3% and 96.6%, respectively). Small numbers with bilateral disease precluded meaningful sub‐group analysis. Conclusions: HPV status is associated with variable management and outcomes in HNSCCUP. Unilateral neck disease is treated variably and associated with poorer outcomes when managed with surgery alone. The impact of diagnostic oropharyngeal surgery on primary site emergence, survival and functional outcomes is unestablished. [ABSTRACT FROM AUTHOR]
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- 2024
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37. Pseudogout and Calcium Pyrophosphate Disease
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Williamson, Andrew
- Published
- 2017
38. Serum Tumor Markers and Outcomes in Patients With Appendiceal Adenocarcinoma
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Yousef, Abdelrahman, primary, Yousef, Mahmoud, additional, Zeineddine, Mohammad A., additional, More, Aditya, additional, Fanaeian, Mohammad, additional, Chowdhury, Saikat, additional, Knafl, Mark, additional, Edelkamp, Paul, additional, Ito, Ichiaki, additional, Gu, Yue, additional, Pattalachinti, Vinay, additional, Naini, Zahra Alavi, additional, Zeineddine, Fadl A., additional, Peterson, Jennifer, additional, Alfaro, Kristin, additional, Foo, Wai Chin, additional, Jin, Jeff, additional, Bhutiani, Neal, additional, Higbie, Victoria, additional, Scally, Christopher P., additional, Kee, Bryan, additional, Kopetz, Scott, additional, Goldstein, Drew, additional, Strach, Madeleine, additional, Williamson, Andrew, additional, Aziz, Omer, additional, Barriuso, Jorge, additional, Uppal, Abhineet, additional, White, Michael G., additional, Helmink, Beth, additional, Fournier, Keith F., additional, Raghav, Kanwal P., additional, Taggart, Melissa W., additional, Overman, Michael J., additional, and Shen, John Paul, additional
- Published
- 2024
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39. Gravitational waves with gamma-ray bursts
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Williamson, Andrew Robert
- Subjects
523.01 ,QB Astronomy ,QC Physics - Abstract
Gravitational waves have now twice been detected emanating from the merging of binary black hole systems. In this thesis we detail the methods used to search for binary merger gravitational wave signals associated with short gamma-ray bursts, focusing on systems that include at least one neutron star. We first cover the background theory behind gravitational wave emission, the means of detection via interferometry, and the types of astrophysical sources that could be detected now or in the near future. We follow this with a review of gamma-ray burst theory and observations, focusing in particular those bursts with short durations. These are likely to be caused by the mergers of binaries that include a neutron star and a black hole, or two neutron stars - events of great interest to gravitational wave astronomy. We then discuss the methods used to search gravitational wave data in a targeted way, using the prior observation of a short gamma-ray bursts to focus the analysis and improve the chances of making a detection. We also summarise early searches of this kind and present the results of a search carried out on LIGO and Virgo data spanning 2005-2010, targeting short gamma-ray bursts detected by the InterPlanetary Network. We then turn our attention to the current, second generation of gravitational wave detectors. We present a detailed calculation of the prospects of success for the targeted short gamma-ray burst search technique, and find that we might reasonably expect to make up to a few detections per year around the turn of the decade. We then outline a new search structure for use during the second generation of detectors, and an astrophysical event alert system for the control rooms of gravitational wave observatories. We end with a presentation of the results of the new and improved search carried out during the first observing run of Advanced LIGO.
- Published
- 2016
40. Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia
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Alanazi, Bader, Munje, Chinmay R., Rastogi, Namrata, Williamson, Andrew J. K., Taylor, Samuel, Hole, Paul S., Hodges, Marie, Doyle, Michelle, Baker, Sarah, Gilkes, Amanda F., Knapper, Steven, Pierce, Andrew, Whetton, Anthony D., Darley, Richard L., and Tonks, Alex
- Published
- 2020
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41. Using concurrent DNA tracer injections to infer glacial flow pathways
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Dahlke, Helen E, Williamson, Andrew G, Georgakakos, Christine, Leung, Selene, Sharma, Asha N, Lyon, Steve W, and Walter, M Todd
- Subjects
Bioengineering ,synthetic DNA ,tracer ,tracer hydrology ,glacier ,flow pathways ,Physical Geography and Environmental Geoscience ,Civil Engineering ,Environmental Engineering - Abstract
Catchment hydrology has become replete with flow pathway characterizations obtained via combinations of physical hydrologic measurements (e.g. streamflow hydrographs) and natural tracer signals (e.g. stable water isotopes and geochemistry). In this study, we explored how our understanding of hydrologic flow pathways can be improved and expanded in both space and time by the simultaneous application of engineered synthetic DNA tracers. In this study, we compared the advective-dispersive transport properties and mass recovery rates of two types of synthetic DNA tracers, one consisting of synthetic DNA strands encapsulated into biodegradable microspheres and another consisting of 'free' DNA, i.e. not encapsulated. The DNA tracers were also compared with a conservative fluorescent dye. All tracers were injected into a small (3.2-km2) valley glacier, Storglaciären, in northern Sweden. Seven of the nine DNA tracers showed clear recovery during the sampling period and similar peak arrival times and dispersion coefficients as the conservative fluorescent dye. However, recovered DNA tracer mass ranged only from 1% to 66%, while recovered fluorescent dye mass was 99%. Resulting from the cold and opaque subglacial environment provided by the glacier, mass loss associated with microbial activity and photochemical degradation of the DNA is likely negligible, leaving sorption of DNA tracers onto suspended particles and loss of microtracer particles to sediment storage as probable explanations. Despite the difference in mass recovery, the advection and dispersion information derived from the DNA tracer breakthrough curves provided spatially explicit information that allowed inferring a theoretical model of the flow pathways that water takes through the glacier.
- Published
- 2015
42. Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
- Author
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Bulut-Karslioglu, Aydan, Jin, Hu, Kim, Yun-Kyo, Cho, Brandon, Guzman-Ayala, Marcela, Williamson, Andrew J. K., Hejna, Miroslav, Stötzel, Maximilian, Whetton, Anthony D., Song, Jun S., and Ramalho-Santos, Miguel
- Published
- 2021
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43. Intrinsic point defects in aluminum antimonide
- Author
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Åberg, Daniel, Erhart, Paul, Williamson, Andrew J., and Lordi, Vincenzo
- Subjects
Condensed Matter - Materials Science - Abstract
Calculations within density functional theory on the basis of the local density approximation are carried out to study the properties of intrinsic point defects in aluminum antimonide. Special care is taken to address finite-size effects, band gap error, and symmetry reduction in the defect structures. The correction of the band gap is based on a set of GW calculations. The most important defects are identified to be the aluminum interstitial $Al_{i,Al}^{1+}$, the antimony antisites $Sb_{Al}^0$ and $Sb_{Al}^{1+}$, and the aluminum vacancy $V_{Al}^{3-}$. The intrinsic defect and charge carrier concentrations in the impurity-free material are calculated by self-consistently solving the charge neutrality equation. The impurity-free material is found to be n-type conducting at finite temperatures., Comment: 11 pages, 5 figures
- Published
- 2010
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44. Scar cosmesis in major head and neck operations: a systematic review of skin closure techniques
- Author
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Williamson, Andrew, primary, Connelly, Andrew, additional, and Awad, Zaid, additional
- Published
- 2024
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45. Vascularized Tissue to Reduce Fistula After Salvage Total Laryngectomy: A Network Meta‐analysis
- Author
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Williamson, Andrew, primary, Shah, Faizan, additional, Benaran, Irene, additional, and Paleri, Vinidh, additional
- Published
- 2024
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46. Performance of artificial intelligence chatbots in sleep medicine certification board exams: ChatGPT versus Google Bard
- Author
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Cheong, Ryan Chin Taw, primary, Pang, Kenny Peter, additional, Unadkat, Samit, additional, Mcneillis, Venkata, additional, Williamson, Andrew, additional, Joseph, Jonathan, additional, Randhawa, Premjit, additional, Andrews, Peter, additional, and Paleri, Vinidh, additional
- Published
- 2023
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47. Early years postgraduate surgical training programmes in the UK are failing to meet national quality standards: An analysis from the ASiT/BOTA Lost Tribe prospective cohort study of 2,569 surgical trainees
- Author
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Glasbey, James C., Harries, Rhiannon L., Beamish, Andrew J., Gokani, Vimal J., Mohan, Helen, Williams, Adam P., Fleming, Simon, Chai, Aaron, Singh, Abhinav, Stoneham, Adam C.S., Lunt, Adam J., Rehman, Adeeb H., Dhahri, Adeel A., Yvon, Adrien R.A., Dutta, Agneish, Abou-Foul, Ahmad K., Abdelrahman, Ahmed, Daoub, Ahmed, Sanalla, Ahmed, de Gea Rico, Aitor, Konarski, Alastair, Ward, Alex E., Wilkin, Alex J., Winter, Alexandra K., Arnaout, Ali, Bakhsh, Ali, Esfandiari, Alireza, Hardy, Alistair W., Khan, Amad N., Thacoor, Amitabh, Gavrila, Ana D., Nedea, Anca-Mihaela, Fontalis, Andreas, Hall, Andrew J., Williamson, Andrew J., Kosti, Angeliki, Harlinska, Anna, Adimonye, Anthony, Egglestone, Anthony, Thaventhiran, Anthony J., Myatt, Antonia, Vusirikala, Anuhya, Rawashdeh, Arab S., Paramasivan, Arjun C., Cotton, Arthur E., Scrimshire, Ashley B., Ramesh, Ashwanth C., Krishnamoorthy, Ashwin K., Ahmed, Asif, Abdul-Hamid, Ayeshah, Khan, Ayushah, Oremule, Babatunde, Ho, Beatrice, Barkham, Ben, Collard, Ben, Edgar, Ben F., Drake, Benjamin, John, Bethan E., Gordon, Catherine R., Rossborough, Catherine, Park, Chang Y., Seretis, Charalampos, Johnson, Charles H.N., Gill, Charn, Serino, Chiara, Ogbuokiri, Chinomso I., Swords, Chloe, Kang, Chong Y., McKinnon, Chris, Brown, Christopher E., Manning, Christopher J., Marusza, Christopher J., Jones, Christopher P., Forde, Cillian T., Wilson, Claire L., Koh, Claudia, Horgan, Conal, Lin, Daniel J., Ashmore, Daniel L., Ness, Daniel, Akhtar, Daniel O., Doherty, Daniel T., Scholfield, Daniel W., Ensor, David C., Bratt, David G., Spence, David J.R., Thomson, David R., Ferguson, David W., Apparau, Denish, Navaratnam, Devaraj M., Mai, Dinh, Rutherford, Duncan G., Karam, Edward, Wu, Eiling, Zimmermann, Eleanor F., Douka, Eleftheria, Flatt, Elinor, Kane, Elizabeth G., Thornhill, Elizabeth L., Gammeri, Emanuele, Littlehales, Emma G., Valsamis, Epaminondas M., Hankin, Erin J., Meenan, Erin R.M., Botha, Etienne N., Khalid, Farhan, Patel, Fatema, Power, Fiachra R., Rutherford, Fiona M., Saeed, Fozia, Guest, Francesca L., Barbosa, Francisco J., Cameron, Fraser G., Raja, Furqan R., Thiruchandran, Gajendiran, Munbauhal, Gavish, Dovey, Gemma E., Hogg, Gemma E., Dovell, George E., Matheron, George, Hill, George T., Layton, Georgia R., Jong, Georgiana G.S., Hicks, Georgina, Millward, Graham J., Shaw, Grahame A., Stamp, Gregory F.W., Parwaiz, Hammad, Chong, Han Hong, Copley, Hannah C., Lennox-Warburton, Hannah C., Emerson, Hannah M., Dean, Harry F., Eltyeb, Hazim, Chu, Howard O., Sadien, Iannish, Mohamed, Imran M., Parwaiz, Iram, Drummond, Isabella M.H., Pearce, Jack C.H., Ahmed, Jacob J., Koris, Jacob, Rait, Jaideep S., Bailey, James A., Cohen, James A., Kennedy, James A., Olivier, James B., Bailey, James, Archer, James E., Stewart, James J., de Barros, James N.J.Monteiro, Allen, James R., O'Brien, James W., James, McGhee, T., Quarcoopome, Jared N., Winyard, Jasmine C., Roberts, Jason L., Barwell, Jennifer S., Rodrigues, Jeremy, Chapman, Jessica A.R., Fairbanks, Jessica Y., Voll, Jessika, Lim, Jie Q., Chang, Jin H., Bovis, Joanna L., Ferns, John, Tam, Johnson Pok Him, Herron, Jonathan B.T., Macdonald, Jonathan D.R., Ducey, Jonathan R., DIxon, Joseph W., Luck, Joshua T., Hewage, Kalon, Yakoub, Kamal M., Bhopal, Kamran F., Vejsbjerg, Karen A., Aboelmagd, Karim, Bera, Katarzyna D., Hamlett, Katharine E., Fok, Katherine E., Hurst, Katherine V., Gillams, Kathryn L., Siggens, Katie L., Young, Katie, Burns, Kenneth M., Burke, Kerry A., Seebah, Kevin, Shah, Khalid A., Bentick, Kieran R., Majid, Kiran, Davies, Kirsty L., Tan, Krystal, Baryeh, Kwaku W., Phillips, Laura A.F., Ellerton, Laura N., Giet, Leeying J., Monaghan, Liam, Ka Cheung, Lok, Shen, Louise L., Paramore, Louise, Arrowsmith, Lucy J., Attwell, Lukas A., Thornton, Luke, Xu, Luting, Leadon, Madeline L., Natarajan, Madhavi, Houlihan, Maria C.R., Cheah, Marisa, Sagmeister, Markus L., Abubakar, Maryam, Flynn, Matthew F., Harris, Matthew, Stone, Matthew J., Young, Matthew J., Gray, Matthew P., Horner, Matthew P., Schembri, Matthew, Trail, Matthew, Joy, Melvin, Rice, Michael J., Thomas, Michael P., Poon, Michael T.C., Stoddart, Michael T., Fong, Michelle L., Foster, Mitchell T., Mohamud, Mohamed F., Hoque, Mohammed N., Remtulla, Mohammedabbas, Javed Karim, Mohsin, Rezacova, Monika, Siddiqui, Muhammad B., Iqbal, Muhammad R., Mensa, Mussa, McCauley, Nadine, Bauer, Natasha J., Walker, Nathan, Hakim, Navid A., Knight, Ngonidzashe, O'Hara, Niall, Fawcett, Nicholas A., Wong, Nicholas, Allen, Nicola F.D., Husnoo, Nilofer, Vallabh, Nimisha, Srikandarajah, Nisaharan, Chidumije, Nnaemeka, Elamin, Obaiy, Akinlaja, Odunayo O., Griffiths, Olga, Brown, Oliver D., Shastri, Oliver, Cameron, Olivia J., Kenyon, Olivia, Javed, Omar A., Sogaolu, Opeyemi O., Birmpili, Panagiota, Haylock-Vize, Patricia, Green, Patrick A., Carroll, Patrick J., Yang, Peiming, Beak, Philip, Persson, Pia, Tam, Pok Him Johnson, Waqar, Rabia, Morley, Rachael L., Bowden, Rachel Clare, Eyre, Rachel L., Pankhania, Rahul M., Sahemey, Rajpreet S., Kabariti, Rakan, Rawashdeh, M., Arab, Rawashdeh S., Rollett, Rebecca A., Nicholas, Rebecca S., Morgan, Rebecca V., Limb, Richard, Robinson, Richard Mark, Hayes, Richard S., Daureeawoo, Ridwan, Cooke, Robert A., Espey, Robert A.J., Chessman, Robert, Whitham, Robert D.J., Payne, Robert E., Staruch, Robert, Alho, Roberto J.R., Gordon, Robin, Cuthbert, Rory, Harrison, Roseanna B., Scott, Rupert A., Parks, Ruth M., Cheong, Ryan C.T., Hillier-Smith, Ryan L., Moffatt, Ryan, Rehman, Saad, Ambren, Sabah, Abdulal, Sabria, Kulkarni, Sagar, Hopwood, Sam, Greenfield, Samantha H., Mehta, Samir K., Haines, Samuel, AlSaati, Sarah A., Williams, Sarah A., El-Badawy, Sarah, Barlow, Sarah L., Pywell, Sarah, Pollock, Sarah-jayne, Lampridis, Savvas, Nazarian, Scarlet, Rezvani, Sean, Scattergood, Sean, Toescu, Sebastian M., Hotonu, Sesi, Shaikh, Shafaque, Rupani, Shamil, Hasan, Shumaila, Pradeep, Shwetha, Cole, Simon J., Growcott, Siona A., Bedoya, Sofia E., Ike, Sonia I., Bodnarescu, Stefan V., Seppings, Stella C., Poyntz, Stephanie A., Jordan, Stevan J., Iqbal, Sundas, Das, Suparna, Chatterjee-Woolman, Suravi, Shumon, Syed, Morrison, Tamsin E.M., Sibartie, Tara, Aboelmagd, Tariq, Russell, Thomas B., Seddon, Thomas C., Stringfellow, Thomas D., Goldsmith, Thomas, Banks, Thomas H.F., Tolley, Thomas, Oputa, Tobenna J., Kanzara, Todd T., Challoner, Tom, Urbonas, Tomas, Richards, Tomos B., Morrison-Jones, Victoria J., Garikapati, Vivek, Al-Azzani, Waheeb A.K., Zahra, Wajiha, Ho, Weiguang, Al-Dhahir, Wesam, Gibson, William G.W., Grant, Yasmin, Hijazi, Yasser, Chiang, Yayganeh, Gundkalli, Zobia K., Seymour, Zoe M., and Panayi, Zoe
- Published
- 2018
- Full Text
- View/download PDF
48. Optical properties of silicon nanoparticles in the presence of water: A first principles theoretical analysis
- Author
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Prendergast, David, Grossman, Jeffrey C., Williamson, Andrew J., Fattebert, Jean-Luc, and Galli, Giulia
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Soft Condensed Matter - Abstract
We investigate the impact of water, a polar solvent, on the optical absorption of prototypical silicon clusters with oxygen passivation. We approach this complex problem by assessing the contributions of three factors: chemical reactivity; thermal equilibration and dielectric screening. We find that the silanone (Si=O) functional group is not chemically stable in the presence of water and exclude this as a source of significant red shift in absorption in aqueous environments. We perform first principles molecular dynamics simulations of the solvation of an oxygenated silicon cluster with explicit water molecules at 300 K. We find a systematic 0.7 eV red shift in the absorption gap of this cluster, which we attribute to thermal strain of the molecular structure. Surprisingly, we find no observable screening impact of the solvent, in contrast with consistent blue shifts observed for similarly sized organic molecules in polar solvents. The predicted red shift is expected to be significantly smaller for larger Si quantum dots produced experimentally, guaranteeing that their vacuum optical properties are preserved even in aqueous environments., Comment: 11 pages, 7 figures, 3 tables. submitted to JACS
- Published
- 2004
49. The Structure and Stokes Shift of Hydrogenated Silicon Nanoclusters
- Author
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Wagner, Lucas, Puzder, Aaron, Williamson, Andrew, Helms, Zachary, Grossman, Jeffrey C., Mitas, Lubos, Galli, Giulia, and Nayfeh, Munir
- Subjects
Condensed Matter - Materials Science - Abstract
We evaluate the optical gap and Stokes shift of several candidate 1 nm silicon nanocrystal structures using density functional and quantum Monte Carlo (QMC) methods. We find that the combination of absorption gap calculations and Stokes shift calculations may be used to determine structures. We find that although absorption gaps calculated within B3LYP and QMC agree for spherical, completely hydrogenated silicon nanocrystals, they disagree in clusters with different surface bonding networks. The nature of the Stokes shift of the ultrabright luminescence is examined by comparing possible relaxation mechanisms. We find that the exciton which reproduces the experimental value of the Stokes shift is most likely a state formed by a collective structural relaxation distributed over the entire cluster.
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- 2004
50. Cognitive emotional analysis of support workers' reaction to challenging behaviour in adults with learning disabilities
- Author
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Williamson, Andrew Ian and MacKenzie, Karen
- Subjects
155 ,ledarning disabilities ,challenging behavior - Abstract
Previous research has explored the applicability of Weiner’s (1986) attributional model of helping behaviour to support workers of people with learning disabilities regarding challenging behaviour using optimism as a measure of the expectancy of success. No research has investigated the applicability of Weiner’s (1993) attributional model of helping behaviour to this group which gives a role to attributions of responsibility. Other research has found that self efficacy affects emotional response to challenging behaviour. The aim of the current research was to examine the relative applicability of these two theories to support workers regarding challenging behaviour using self efficacy as a measure of the expectancy of success. Method A total of 88 support workers completed measures addressing causal attributional dimensions, emotional reactions, attribution of responsibility, self efficacy and willingness to help in response to each of three vignettes regarding the challenging behaviours of aggression, self injury and destruction of property. Data was analysed using Spearman’s r correlations. Results None of the hypothesised significant correlations were found between measures of causal attributional dimensions and measures of responsibility or self efficacy. Attributing responsibility for the development of a challenging behaviour to the person engaging in it was significantly positively correlated with negative emotion. Self efficacy was significantly negatively correlated with negative emotion and significantly positively correlated with willingness to help. Emotional reaction was not significantly correlated with willingness to help. Conclusions The results provided little support for Weiner’s (1993) attributional theory of helping behaviour but provided more support for the expectancy of success aspect of Weiner’s (1986) theory and indicated that self efficacy is a useful measure of the expectancy of success. No firm conclusion could be drawn as to whether the failure to find significant correlations between causal attributions and other aspects of the theories was a genuine finding or due to the modified use of the Challenging Behaviour Attributions scale. It is concluded that a measure specifically designed for measuring causal attributional dimensions in this area is required. It is also concluded that low self efficacy may contribute to the development and maintenance of challenging behaviour via its impact on support workers’ intent to help. Efforts should therefore be made to raise support workers’ self efficacy by altering the perceived cause of challenging behaviour and highlighting to support workers the role of their level of effort, adherence to support plans and the role of any temporary external factors in the development and maintenance of challenging behaviour.
- Published
- 2008
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