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1. Manifestaciones gastrointestinales de la enfermedad de Behçet

Author

Nicolás Zuluaga Arbeláez, Oscar Mauricio Ardila Suarez, Andrés Chavarriaga Restrepo, and Wilmer Gerardo Rojas-Zuleta

Subjects
General Medicine
Abstract

La Enfermedad de Behçet (EB), es una entidad poco común, idiopática, de naturaleza crónica y recurrente con afectación multisistémica. Entre ellos, el tracto gastrointestinal ha suscitado especial interés, al asociarse a mayor morbimortalidad y dado sus presentaciones heterogéneas puede simular otras enfermedades gastrointestinales y ser un gran reto diagnóstico para el gastroenterólogo. Por lo tanto, presentamos una revisión narrativa donde se pretenderá describir las manifestaciones gastrointestinales de la EB y sus diagnósticos diferenciales.

Published
2022

2. High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey

Author

Silvia, Grignaschi, Minchul, Kim, Giovanni, Zanframundo, Naveen, Ravichandran, Lilleker, James B., Parikshit, Sen, Mrudula, Joshi, Vishwesh, Agarwal, Sinan, Kardes, Jessica, Day, Ashima, Makol, Marcin, Milchert, Tamer, Gheita, Babur, Salim, Tsvetelina, Velikova, Abraham Edgar Gracia-Ramos, Ioannis, Parodis, Elena, Nikiphorou, Tulika, Chatterjee, Ai Lyn Tan, Saavedra, Miguel A., Samuel Katsuyuki Shinjo, Nelly, Ziade, Johannes, Knitza, Masataka, Kuwana, Arvind, Nune, Oliver, Distler, Hector, Chinoy, Lorenzo, Cavagna, Vikas, Agarwal, Rohit, Aggarwal, Latika, Gupta, Bhupen, Barman, Yogesh Preet Singh, Rajiv, Ranjan, Avinash, Jain, Sapan, C Pandya, Rakesh Kumar Pilania, Aman, Sharma, M Manesh Manoj, Vikas, Gupta, Chengappa, G Kavadichanda, Pradeepta Sekhar Patro, Sajal, Ajmani, Sanat, Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha, Shenoy, Ajay, Asranna, Keerthi Talari Bommakanti, Anuj, Shukla, Arunkumar, R Pande, Kunal, Chandwar, Döndü Üsküdar Cansu, John, D Pauling, Chris, Wincup, Nicoletta Del Papa, Gianluca, Sambataro, Atzeni, Fabiola, Marcello, Govoni, Simone, Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico, Fusaro, Marco, Sebastiani, Quartuccio, Luca, Franceschini, Franco, Pier Paolo Sainaghi, Giovanni, Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo, Venerito, Lisa, S Traboco, Suryo Anggoro Kusumo Wibowo, Jorge Rojas Serrano, Ignacio García-De La Torre, Erick Adrian Zamora Tehozol, Jesús, Loarce-Martos, Sergio, Prieto-González, Raquel Aranega Gonzalez, Akira, Yoshida, Ran, Nakashima, Shinji, Sato, Naoki, Kimura, Yuko, Kaneko, Stylianos, Tomaras, Margarita Aleksandrovna Gromova, Aharonov, Or, Ihsane, Hmamouchi, Leonardo Santos Hoff, Margherita, Giannini, François, Maurier, Julien, Campagne, Alain, Meyer, Melinda, Nagy-Vincze, Daman, Langguth, Vidya, Limaye, Merrilee, Needham, Nilesh, Srivastav, Marie, Hudson, Océane, Landon-Cardinal, Syahrul Sazliyana Shaharir, Wilmer Gerardo Rojas Zuleta, José António Pereira Silva, and João Eurico Fonseca

Subjects
Myositis, Surveys and questionnaires, Autoimmune diseases, COVID-19, Fatigue
Published
2023

3. COVAD survey 2 long-term outcomes: unmet need and protocol

Author

Zoha Zahid Fazal, Parikshit, Sen, Mrudula, Joshi, Naveen, Ravichandran, Lilleker, James B., Vishwesh, Agarwal, Sinan, Kardes, Minchul, Kim, Jessica, Day, Ashima, Makol, Marcin, Milchert, Tamer, Gheita, Babur, Salim, Tsvetelina, Velikova, Abraham Edgar Gracia-Ramos, Ioannis, Parodis, Elena, Nikiphorou, Ai Lyn Tan, Tulika, Chatterjee, Lorenzo, Cavagna, Saavedra, Miguel A., Samuel Katsuyuki Shinjo, Nelly, Ziade, Albert, Selva-O’Callaghan, Arvind, Nune, Johannes, Knitza, Masataka, Kuwana, Carlos-Enrique Toro Gutiérrez, Carlo Vinicio Caballero-Uribe, Dzifa, Dey, Oliver, Distler, Hector, Chinoy, Vikas, Agarwal, Rohit, Aggarwal, Latika Gupta, COVAD Study Group: Barman, Yogesh Preet Singh, Rajiv, Ranjan, Avinash, Jain, Sapan, C Pandya, Rakesh Kumar Pilania, Aman, Sharma, Manesh Manoj, M, Vikas, Gupta, Chengappa, G Kavadichanda, Pradeepta Sekhar Patro, Sajal, Ajmani, Sanat, Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha, Shenoy, Ajay, Asranna, Keerthi Talari Bommakanti, Anuj, Shukla, Arun Kumar, R Pandey, Prithvi Sanjeevkumar Gaur, Mahabaleshwar, Mamadapur, Akanksha, Ghodke, Kunal, Chandwar, Kshitij, Jagtap, Döndü Üsküdar Cansu, Reşit, Yıldırım, Aarat, Patel, John, D Pauling, Chris, Wincup, Margherita, Giannini, François, Maurier, Julien, Campagne, Alain, Meyer, Nicoletta Del Papa, Gianluca, Sambataro, Atzeni, Fabiola, Marcello, Govoni, Simone, Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico, Fusaro, Marco, Sebastiani, Quartuccio, Luca, Franceschini, Franco, Pier Paolo Sainaghi, Giovanni, Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo, Venerito, Silvia, Grignaschi, Alessandro, Giollo, Lisa, S Traboco, Syahrul Sazliyana Shaharir, Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio García-De La Torre, Colunga‑pedraza, Iris J., Javier, Merayo-Chalico, Jesús, Loarce-Martos, Sergio, Prieto-González, Albert, Gil-Vila, Raquel, Aranega, Leonardo Santos Hoff, Ran, Nakashima, Shinji, Sato, Naoki, Kimura, Yuko, Kaneko, Stylianos, Tomaras, Fabian Nikolai Proft, Marie-Therese, Holzer, Margarita Aleksandrovna Gromova, Aharonov, Or, Melinda, Nagy-Vincze, Zoltán, Griger, Ihsane, Hmamouchi, Pr Imane El bouchti, Zineb, Baba, Uyi, Ima-Edomwonyi, Ibukunoluwa, Dedeke, Emorinken, Airenakho, Nwankwo Henry Madu, Abubakar, Yerima, Hakeem, Olaosebikan, Okwara Celestine Chibuzo, Becky, A, Ouma Devi Koussougbo, Elisa, Palalane, Daman, Langguth, Vidya, Limaye, Merrilee, Needham, Nilesh, Srivastav, Marie, Hudson, Océane, Landon-Cardinal, Wilmer Gerardo Rojas Zuleta, Álvaro, Arbeláez, Javier, Cajas, José António Pereira Silva, João Eurico Fonseca, Olena, Zimba, Doskaliuk, Bohdana, Ho, So, Manuel Francisco Ugarte-Gil, Lyn, Chinchay, José Proaño Bernaola, Victorio, Pimentel, Tanveer Hasan, A. T. M., Sreoshy, Saha, Binit, Vaidya, Hanan Mohamed Fathi, Reem Hamdy, A Mohammed, Yi-Ming, Chen, Ghita, Harifi, Lina El Kibbi, Hussein Mohammed Halabi, Akawatcharangura, P, Wanruchada, Katchamart, Yurilís, Fuentes-Silva, Karoll, Cabriza, Jonathan, Losanto, Nelly, Colaman, Antonio, Cachafeiro-Vilar, Generoso Guerra Bautista, Enrique Julio Giraldo Ho, Raúl Agustín González, Lilith Stange Nunez, Cristian Vergara, M, Jossiell Then Báez, Hugo, Alonzo, Carlos Benito Santiago Pastelin, Rodrigo García Salinas, Alejandro Quiñónez Obiols, Nilmo, Chávez, Andrea Bran Ordóñez, Sandra, Argueta, Daniel, Quijivix, Gil Alberto Reyes Llerena, Radames, Sierra-Zorita, Dina, Arrieta, Eduardo Romero Hidalgo, Ricardo, Saenz, Idania Escalante, M., Roberto, Morales, Wendy, Calapaqui, Ivonne, Quezada, Gabriela, Arredondo, Institut Català de la Salut, [Fazal ZZ] Medical College, Aga Khan University Hospital, National Stadium Road, Sindh, Pakistan. [Sen P] Maulana Azad Medical College, 2-Bahadurshah Zafar Marg, New Delhi, India. [Joshi M] Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India. [Ravichandran N] Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. [Lilleker JB] Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. Neurology, Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford, UK. [Agarwal V] Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India. [Selva-O'Callaghan A] Unitat d’Inflamació i Autoimmunitat, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Autoimmune diseases, COVID-19, Long-term adverse effects, Registries, Vaccination, COVID-19 Vaccines, COVID-19/prevention & control, Immunology, Complex Mixtures::Biological Products::Vaccines::Viral Vaccines [CHEMICALS AND DRUGS], Otros calificadores::Otros calificadores::/efectos adversos [Otros calificadores], Enquestes, Antiviral Agents, Rheumatology, Other subheadings::Other subheadings::/adverse effects [Other subheadings], virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Immunology and Allergy, Humans, Pandemics/prevention & control, Vacunes - Efectes secundaris, Pandemics, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], mezclas complejas::productos biológicos::vacunas::vacunas víricas [COMPUESTOS QUÍMICOS Y DROGAS], Long term adverse effects, Covid-19, COVID-19 (Malaltia) - Vacunació, COVID-19 Vaccines/adverse effects
Abstract

COVID-19; Registries; Vaccination COVID-19; Registros; Vacunación COVID-19; Registres; Vacunació Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, and antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy to manage pandemic. Although none of the currently approved vaccines are live-attenuated, several reports of disease flares, waning protection, and acute-onset syndromes have emerged as short-term adverse events after vaccination. Hence, scientific literature falls short when discussing potential long-term effects in vulnerable cohorts. The COVAD-2 survey follows on from the baseline COVAD-1 survey with the aim to collect patient-reported data on the long-term safety and tolerability of COVID-19 vaccines in immune modulation. The e-survey has been extensively pilot-tested and validated with translations into multiple languages. Anticipated results will help improve vaccination efforts and reduce the imminent risks of COVID-19 infection, especially in understudied vulnerable groups. HC is supported by the National Institution for Health Research Manchester Biomedical Research Centre Funding Scheme. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health.

Published
2022

4. COVID-19 vaccine safety during the antenatal period in women with idiopathic inflammatory myopathies

Author

Andreoli, Laura, Parikshit, Sen, Lini, Daniele, Melinda Nagy Vincze, Karen, Schreiber, COVAD Study Group, Vikas, Agarwal, Rohit, Aggarwal, Latika Gupta The COVAD study group includes: Naveen, R, Mrudula, Joshi, Sreoshy, Saha, Kshitij, Jagtap, Lilleker, James B., Vishwesh, Agarwal, Sinan, Kardes, Jessica, Day, Marcin, Milchert, Tamer, Gheita, Babur, Salim, Tsvetelina, Velikova, Abraham Edgar Gracia-Ramos, Ioannis, Parodis, Elena, Nikiphorou, Tulika, Chatterjee, Ai Lyn Tan, Lorenzo, Cavagna, Saavedra, Miguel A., Samuel Katsuyuki Shinjo, Nelly, Ziade, Johannes, Knitza, Masataka, Kuwana, Arvind, Nune, Oliver, Distler, Hector, Chinoy, Ashima, Makol, Dzifa, Dey, Carlos Enrique Toro Gutie´rrez, Carlo Vinicio Caballero-Uribe, Bhupen, Barman, Yogesh Preet Singh, Rajiv, Ranjan, Avinash, Jain, Pandya, Sapan C., Rakesh Kumar Pilania, Aman, Sharma, Manesh, Manoj, Vikas, Gupta, Kavadichanda, Chengappa G., Pradeepta Sekhar Patro, Sajal, Ajmani, Sanat, Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha, Shenoy, Ajay, Asranna, Keerthi Talari Bommakanti, Anuj, Shukla, Pande, Arunkumar R., Kunal, Chandwar, Akanksha, Ghodke, Zoha Zahid Fazal, Do¨ndu¨ U¨ sku¨ dar Cansu, Res¸it, Yıldırım, Aarat, Patel, Pauling, John D., Chris, Wincup, Armen Yuri Gasparyan, Nicoletta Del Papa, Gianluca, Sambataro, Atzeni, Fabiola, Marcello, Govoni, Simone, Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico, Fusaro, Marco, Sebastiani, Quartuccio, Luca, Franceschini, Franco, Pier Paolo Sainaghi, Giovanni, Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo, Venerito, Silvia, Grignaschi, Alessandro, Giollo, Alessia, Alluno, Florenzo, Ioannone, Marco, Fornaro, Lisa, S Traboco, Syahrul Sazliyana Shaharir, Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garc ıa-De La Torre, Colunga-Pedrazza, Iris J., Javier Merayo Chalico, Jesu´, s Loarce-Martos, Sergio Prieto-Gonza´ lez, Raquel Aranega Gonzalez, Leonardo Santos Hoff, Akira, Yoshida, Ran, Nakashima, Shinji, Sato, Naoki, Kimura, Yuko, Kaneko, Takahisa, Gono, Stylianos, Tomaras, Fabian Nikolai Proft, Marie-Therese, Holzer, Russka, Shumnalieva, Margarita Aleksandrovna Gromova, Aharonov, Or, Zolta´n, Griger, Ihsane, Hmamouchi, Imane El bouchti, Zineb, Baba, Margherita, Giannini, Franc¸ois, Maurier, Julien, Campagne, Alain, Meyer, Daman, Langguth, Vidya, Limaye, Merrilee, Needham, Nilesh, Srivastav, Marie, Hudson, Oce´ane, Landon-Cardinal, Wilmer Gerardo Rojas Zuleta, ´ lvaro Arbela´ez, A, Javier, Cajas, Jose´ Anto´nio Pereira Silva, Jo~ao Eurico Fonseca, Olena, Zimba, Doskaliuk, Bohdana, Uyi, Ima-Edomwonyi, Ibukunoluwa, Dedeke, Emorinken, Airenakho, Nwankwo Henry Madu, Abubakar, Yerima, Hakeem, Olaosebikan, Okwara Celestine Chibuzo, Becky, Adugna, Oruma Devi Koussougbo, Elisa, Palalane, Ho, So, Manuel Francisco Ugarte-Gil, Lyn, Chinchay, Jose´ Proa~no Bernaola, Victorio, Pimentel, Tanveer Hasan, A. T. M., Binit, Vaidya, Hanan Mohammed Fathi, Mohammed, Reem Hamdy A., Yi-Ming, Chen, Ghita, Harifi, Lina El Kibbi, Hussein Mohammed Halabi, Akawatcharangura, P., Wanruchada, Katchamart, Yuril ıs Fuentes-Silva, Karoll, Cabriza, Jonathan, Losanto, Nelly, Colaman, Antonio, Cachafeiro-Vilar, Generoso Guerra Bautista, Enrique Julio Giraldo Ho, Rau´, l Gonza´ lez, Lilith Stange Nunez, Cristian Vergara, M, Jossiell Then Ba´ez, Hugo, Alonzo, Carlos Benito Santiago Pastelin, Rodrigo Garc ıa Salinas, Alejandro Qui~no´nez Obiols, Nilmo, Cha´vez, Andrea Bran Ordo´ ~nez, Sandra, Argueta, Gil Alberto Reyes Llerena, Radames, Sierra-Zorita, Dina, Arrieta, Eduardo Romero Hidalgo, Ricardo, Saenz, Idania Escalante, M, Roberto, Morales, Wendy, Calapaqui, Ivonne, Quezada, and Gabriela, Arredondo

Subjects
Rheumatology, Pharmacology (medical)
Published
2022

5. COVID-19 vaccination in autoimmune diseases (COVAD) study: vaccine safety and tolerance in rheumatoid arthritis

Author

Naveen, R, Ioannis, Parodis, Mrudula, Joshi, Parikshit, Sen, Julius, Lindblom, Vishwesh, Agarwal, James, B Lilleker, Ai Lyn Tan, Arvind, Nune, Samuel Katsuyuki Shinjo, Babur, Salim, Nelly, Ziade, Tsvetelina, Velikova, Abraham Edgar Gracia-Ramos, Miguel, A Saavedra, Jessica, Day, Ashima, Makol, Oliver, Distler, Hector, Chinoy, COVAD Study Group, Vikas Agarwal, Rohit Aggarwal, Latika, Gupta, Elena Nikiphorou The COVAD study group collaborators are: Bhupen Barman, Yogesh Preet Singh, Rajiv, Ranjan, Avinash, Jain, Pandya, Sapan C., Rakesh Kumar Pilania, Aman, Sharma, Manoj, M, Vikas, Gupta, Kavadichanda, Chengappa G., Pradeepta Sekhar Patro, Sajal, Ajmani, Sanat, Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha, Shenoy, Ajay, Asranna, Keerthi Talari Bommakanti, Anuj, Shukla, Pandey, Arun Kumar R., Kunal, Chandwar, Sinan, Kardes¸, Do¨ndu¨ U¨ sku¨ dar Cansu, Minchul, Kim, Tulika, Chatterjee, Pauling, John D., Chris, Wincup, Lorenzo, Cavagna, Nicoletta Del Papa, Gianluca, Sambataro, Atzeni, Fabiola, Marcello, Govoni, Simone, Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico, Fusaro, Marco, Sebastiani, Quartuccio, Luca, Franceschini, Franco, Pier Paolo Sainaghi, Giovanni, Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo, Venerito, Marcin, Milchert, Traboco, Lisa S., Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garc ıa-De La Torre, Jesu´, s Loarce-Martos, Sergio Prieto-Gonza´ lez, Albert, Gil-Vila, Raquel Aranega Gonzalez, Masataka, Kuwana, Akira, Yoshida, Ran, Nakashima, Shinji, Sato, Naoki, Kimura, Yuko, Kaneko, Johannes, Knitza, Stylianos, Tomaras, Margarita Aleksandrovna Gromova, Aharonov, Or, Gheita, Tamer A., Ihsane, Hmamouchi, Leonardo Santos Hoff, Margherita, Giannini, Franc¸ois, Maurier, Julien, Campagne, Alain, Meyer, Melinda, Nagy-Vincze, Daman, Langguth, Vidya, Limaye, Merrilee, Needham, Nilesh, Srivastav, Marie, Hudson, Oce´ane, Landon-Cardinal, Syahrul Sazliyana Shaharir, Wilmer Gerardo Rojas Zuleta, Jose´ Anto´ nio Pereira Silva, Jo~ao Eurico Fonseca, and Olena, Zimba.

Subjects
rheumatoid arthritis, Adverse effects, COVID-19, autoimmune diseases, vaccination, Rheumatology, Pharmacology (medical)
Abstract

Objectives The COVID-19 vaccination in autoimmune diseases (COVAD) study aimed to assess short-term COVID-19 vaccination-related adverse events (AEs) in RA patients. Methods An online self-reported questionnaire (March–December 2021) was used to capture data related to COVID-19 vaccination-related AEs in RA, other autoimmune rheumatic diseases (AIRDs) (excluding RA and inflammatory myositis), non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs). Descriptive and multivariable regression analyses were performed. Results Of the 9462 complete respondents, 14.2% (n = 1347) had been diagnosed with RA; they had a mean (s.d.) age of 50.7 (13.7) years, 74.2% were women and 49.3% were Caucasian. In total, 76.9% and 4.2% of patients with RA reported minor and major AEs, respectively. Patients with active and inactive RA had similar AE and hospitalization frequencies. Overall, AEs were reported more frequently by BNT162b2 and mRNA-1273 recipients and less frequently by BBV152 recipients compared with the rest. Major AE and hospitalization frequencies were similar across recipients of different vaccines. Patients receiving methotrexate and hydroxychloroquine reported fewer minor AEs than those patients not on them. Compared with HCs and patients with other AIRDs, patients with RA reported similar total AEs, overall minor AEs, and hospitalizations. Compared with nrAIDs, patients with RA reported lower frequencies of overall AEs, minor AEs (both odds ratio [OR] = 0.7; 95% CI: 0.5, 0.9), and injection site pain (OR = 0.6; 95% CI: 0.5, 0.8) with similar major AE and hospitalization frequencies. Conclusion Despite the differences in AE frequency across different COVID-19 vaccines, all were well tolerated in patients with RA and were comparable to HCs, providing reassurance as to the safety of COVID-19 vaccination.

Published
2022

7. Recommendations for rheumatologists on pharmacological management during the COVID-19 health emergency: Expert group opinion

Author

Jhyld-Carolaind Camacho-Barbosa, Claudia-Lucía Giraldo Herrera, Josué-Guillermo López, Catalina Orozco González, Wilmer-Gerardo Rojas-Zuleta, Jorge-Hernando Donado, Lácides Padilla-Tovar, Rodrigo Giraldo-Bustos, Oscar-Jair Felipe-Díaz, Jesús-Giovanny Ballesteros, Natalia Duque-Zapata, Erika-Paola Navarro-Mendoza, and María-José López-Mora

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Antimaláricos, Pharmacological management, Terapia con medicamentos, Economic shortage, Context (language use), Disease, Antimalarials, Rheumatology, Drug Therapy, Reflexion Article, Pandemic, medicine, Intensive care medicine, skin and connective tissue diseases, business.industry, COVID-19, General Medicine, medicine.disease, Reumatología, Expert group, Coronavirus, Rheumatoid arthritis, Drug therapy, business
Abstract

RESUMEN La enfermedad por Coronavirus 2019 (COVID-19) es una pandemia inesperada que ha pro vocado un estado de emergencia y que ha generado cambios drásticos en los protocolos de atención clínica. Para su tratamiento se ha descrito el papel de algunos medicamen tos usados habitualmente en artritis reumatoide, lupus eritematoso sistémico y otras enfermedades autoinmunitarias sistémicas. Debido a ello, existe un inminente riesgo de desabastecimiento, por lo cual el objetivo de esta revisión narrativa y opinión de expertos es formular recomendaciones generales clínicas y administrativas sobre el manejo de pacien tes ambulatorios con enfermedad autoinmunitaria o inflamatoria sistémica en el contexto de la pandemia por COVID-19. ABSTRACT Coronavirus 2019 (COVID-19) is an unexpected pandemic that has caused a state of emergency, as well as generating drastic changes in clinical care protocols. Some drugs commonly used in rheumatoid arthritis, systemic lupus erythematosus, and other systemic autoimmune diseases have been described for its treatment. Therefore, there is an imminent risk of shortages. The aim of this narrative review and expert opinion is to present general recommendations on the clinical and administrative management of outpatients with autoimmune or systemic inflammatory disease, in the context of the COVID-19 pandemic.

Published
2022

8. Recomendaciones para reumatólogos sobre el manejo farmacológico durante la emergencia sanitaria por COVID-19: opinión de un grupo de expertos

Author

Catalina Orozco González, Wilmer-Gerardo Rojas-Zuleta, Josué-Guillermo López, Jhyld-Carolaind Camacho-Barbosa, Oscar-Jair Felipe-Díaz, Lácides Padilla-Tovar, María-José López-Mora, Rodrigo Giraldo-Bustos, Jorge-Hernando Donado, Erika-Paola Navarro-Mendoza, Jesús-Giovanny Ballesteros, Claudia-Lucía Giraldo Herrera, and Natalia Duque-Zapata

Subjects
030203 arthritis & rheumatology, business.industry, antimaláricos, coronavirus, COVID-19, Reumatología, Article, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, terapia con medicamentos, Medicine, 030212 general & internal medicine, business, Humanities
Abstract

Resumen La enfermedad por Coronavirus 2019 (COVID-19) es una pandemia inesperada que ha provocado un estado de emergencia y que ha generado cambios drasticos en los protocolos de atencion clinica. Para su tratamiento se ha descrito el papel de algunos medicamentos usados habitualmente en artritis reumatoide, lupus eritematoso sistemico y otras enfermedades autoinmunitarias sistemicas. Debido a ello, existe un inminente riesgo de desabastecimiento, por lo cual el objetivo de esta revision narrativa y opinion de expertos es formular recomendaciones generales clinicas y administrativas sobre el manejo de pacientes ambulatorios con enfermedad autoinmunitaria o inflamatoria sistemica en el contexto de la pandemia por COVID-19.

Published
2021
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9. AB0441 THERAPY WITH TOFACITINIB IN A COLOMBIAN POPULATION WITH RHEUMATOID ARTHRITIS: RESULTS OF THE DAILY CLINICAL PRACTICE

Author

Wilmer Gerardo Rojas Zuleta, Monica Vasquez Jaramillo, Jorge Hernando Donado Gómez, Natalia Duque Zapata, Catalina Orozco González, Oscar Díaz, Claudia Lucía Giraldo Herrera, and Adelis Enrique Pantoja Marquez

Subjects
medicine.medical_specialty, Tofacitinib, business.industry, medicine.disease, Comorbidity, Blood pressure, Interquartile range, Rheumatoid arthritis, Internal medicine, Cohort, medicine, Methotrexate, business, Leflunomide, medicine.drug
Abstract

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the quality of life and reduces life expectancy. It is characterized by the presence of autoantibodies and erosive synovitis that mainly involves small joints (1). Tofacitinib is the first oral Janus Kinase (JAK) inhibitor approved in 2012 for the treatment of patients with active, moderate to severe RA that does not respond to other therapies (2). Objectives: The objective was to describe demographic and clinical results of a cohort of Colombian patients with RA treated with tofacitinib. Methods: Descriptive observational study of a historical cohort of RA patients in a specialized center for the management of inflammatory arthropathies, from April 2014 to February 2018. The following variables are described: age, sex, time evolution of the disease, type of AR, comorbidities, disease activity (DAS-28), schedule and treatment time. For the descriptive analysis, categorical variables are presented as absolute and relative frequencies; while continuous variables are presented as mean and standard deviation (SD) or median and interquartile range (IQR) according to distribution. The outcome of DAS 28 ≤ 3.2 was estimated by incidence rate, defined as the number of patients who presented the outcome divided by the summation of total exposure time of the patients. Results: Of 59 patients included, 88.1% (52) were women, with a median age of 58.8 years (IQR 49-68 years), 74.6% were seropositive, the median time from diagnosis was 18.2 years (IQR 12- 28.3 years). High blood pressure was the most common comorbidity (40.7%) and 7% had tuberculosis history. The median number of bDMARD prior to tofacitinib was 2 (IQR 1-3). Sixty six percent patients (39) were on monotherapy while 34% (20) were on combination with leflunomide (19) and methotrexate (1). The median time of treatment was 1.2 years (IQR 0.6-2 years). At the beginning, 84.7% patients (50) were in moderate or high disease activity and 15,3% (9) in remission or low activity; at the end of follow-up, 47.5% (28) were in remission or low activity and 52.5% (31) in moderate or high activity (p = 0.000). The mean DAS28 at the beginning of tofacitinib was 4.6 ± 1.55 and at the end of the follow-up was 3.5 ± 1.49, with a difference of means of 1.10 (IC95% 0.62-1.57), (p 0.00). During the follow-up period, the rate of development of remission or low activity was 11.92 (95% CI 8.35-16.51) cases per 100 people-month observed (p 0.00). Only 2 patients developed therapeutic failure. Conclusion: Tofacitinib shows a good profile of effectivity in patients with failure to prior bDMARD. Almost 50% patient reaches low disease activity or remission during follow up and low number of therapeutic failure was found. References [1] Picchianti-Diamanti A, et al. Front Microbiol. 2018;8(2696):1-9 [2] Cohen S, et al. Rheumatol Ther. 2018;5(1):283-291 Disclosure of Interests: Wilmer Gerardo Rojas Zuleta Speakers bureau: Bristol-Myers Squibb, Novartis, Jannsen, Pfizer, Oscar Jair Felipe Diaz Speakers bureau: Bristol-Myers Squibb, Novartis, Jannsen, Pfizer, Claudia Lucia Giraldo Herrera Speakers bureau: Novartis, Abbvie, Adelis Enrique Pantoja Marquez: None declared, Natalia Duque Zapata: None declared, Monica Vasquez Jaramillo: None declared, Catalina Orozco Gonzalez: None declared, Jorge Hernando Donado Gomez: None declared

Published
2019

10. Th9 lymphocytes: A recent history from IL-9 to its potential role in rheumatic diseases

Author

Wilmer Gerardo Rojas-Zuleta and Gloria Vásquez

Subjects
0301 basic medicine, Immunology, Autoimmunity, Biology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Immunity, Rheumatic Diseases, medicine, Animals, Humans, Lupus Erythematosus, Systemic, Immunology and Allergy, Interleukin 9, Transcription factor, Scleroderma, Systemic, Effector, Interleukin-9, Cancer, Cell Differentiation, T-Lymphocytes, Helper-Inducer, medicine.disease, 030104 developmental biology, Cytokine secretion, Signal transduction, 030215 immunology
Abstract

Various subtypes of effector T cells have been described up to date, and each one has its specific immunological function and a defined cytokine secretion profile. Th9 lymphocytes, recently described, are characterized by a high IL-9 expression. Their differentiation requires the integration of IL-4 and TGF-β signaling pathways and the coordinated participation of multiple transcription factors. Their role has been mainly found in immunity against parasites and in allergic inflammatory processes. Nevertheless, they have been implicated in processes as autoimmunity, cancer and recently in rheumatic diseases. The objective of this review is to describe the discovery of this cellular subtype, its differentiation, expression regulation and its potential role in rheumatic diseases.

Published
2016

11. IL-9: Function, Sources, and Detection

Author

Wilmer Gerardo, Rojas-Zuleta and Elizabeth, Sanchez

Subjects
Th2 Cells, Hypersensitivity, Interleukin-9, Cytokines, Humans, Th17 Cells, T-Lymphocytes, Regulatory, Asthma
Abstract

IL-9 is a pleiotropic cytokine produced in different amounts by a wide variety of cells including mast cells, NKT cells, Th2, Th17, Treg, ILC2, and Th9 cells. Th9 cells are considered to be the main CD4+ T cells that produce IL-9. IL-9 exerts its effects on multiple types of cells and different tissues. To date, its main role has been found in the immune responses against parasites and pathogenesis of allergic diseases such as asthma and bronchial hyperreactivity. Additionally, it induces the proliferation of hematologic neoplasias, including Hodgkin's lymphoma in humans. However, IL-9 also has antitumor properties in solid tumors such as melanoma. The objective of this review is to describe IL-9, its function, sources, and methods of detection.

Published
2017

12. IL-9: Function, Sources, and Detection

Author

Elizabeth Sanchez and Wilmer Gerardo Rojas-Zuleta

Subjects
0301 basic medicine, medicine.medical_treatment, Biology, Natural killer T cell, Interleukin 33, 03 medical and health sciences, 030104 developmental biology, Immune system, Cytokine, Interleukin 15, Immunology, medicine, Interleukin 9, Interleukin 5, Interleukin 3
Abstract

IL-9 is a pleiotropic cytokine produced in different amounts by a wide variety of cells including mast cells, NKT cells, Th2, Th17, Treg, ILC2, and Th9 cells. Th9 cells are considered to be the main CD4+ T cells that produce IL-9. IL-9 exerts its effects on multiple types of cells and different tissues. To date, its main role has been found in the immune responses against parasites and pathogenesis of allergic diseases such as asthma and bronchial hyperreactivity. Additionally, it induces the proliferation of hematologic neoplasias, including Hodgkin's lymphoma in humans. However, IL-9 also has antitumor properties in solid tumors such as melanoma. The objective of this review is to describe IL-9, its function, sources, and methods of detection.

Published
2017

13. Global disparities in the treatment of idiopathic inflammatory myopathies: results from an international online survey study

Author

Nelly, Ziade, Marc, Aoude, Ihsane, Hmamouchi, Naveen, R, James, B Lilleker, Parikshit, Sen, Mrudula, Joshi, Vishwesh, Agarwal, Sinan, Kardes, Jessica, Day, Ashima, Makol, Marcin, Milchert, Tamer, Gheita, Babur, Salim, Tsvetelina, Velikova, Abraham Edgar Gracia-Ramos, Ioannis, Parodis, Elena, Nikiphorou, Tulika, Chatterjee, Ai Lyn Tan, Miguel, A Saavedra, Samuel Katsuyuki Shinjo, Johannes, Knitza, Masataka, Kuwana, Arvind, Nune, Lorenzo, Cavagna, Oliver, Distler, Hector, Chinoy, Vikas, Agarwal, Rohit, Aggarwal, Latika, Gupta, and the COVAD Study Group Authors: Bhupen Barman, Yogesh Preet Singh, Rajiv, Ranjan, Avinash, Jain, Sapan, C Pandya, Rakesh Kumar Pilania, Aman, Sharma, Manesh Manoj, M, Vikas, Gupta, Chengappa, G Kavadichanda, Pradeepta Sekhar Patro, Sajal, Ajmani, Sanat, Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha, Shenoy, Ajay, Asranna, Keerthi Talari Bommakanti, Anuj, Shukla, Arunkumar, R Pande, Kunal, Chandwar, Döndü Üsküdar Cansu, John, D Pauling, Chris Wincup Nicoletta Del Papa, Gianluca, Sambataro, Atzeni, Fabiola, Marcello, Govoni, Simone, Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico, Fusaro, Marco, Sebastiani, Quartuccio, Luca, Franceschini, Franco, Pier Paolo Sainaghi, Giovanni, Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo, Venerito, Lisa, S Traboco, Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio García-De La Torre, Jesús, Loarce-Martos, Sergio, Prieto-González, Raquel Aranega Gonzalez, Akira, Yoshida, Ran, Nakashima, Shinji, Sato, Naoki, Kimura, Yuko, Kaneko, Stylianos, Tomaras, Margarita Aleksandrovna Gromova, Aharonov, Or, Leonardo Santos Hoff, Margherita, Giannini, François, Maurier, Julien, Campagne, Alain, Meyer, Melinda, Nagy-Vincze, Daman, Langguth, Vidya, Limaye, Merrilee, Needham, Nilesh, Srivastav, Marie, Hudson, Océane, Landon-Cardinal, Syahrul Sazliyana Shaharir, Wilmer Gerardo Rojas Zuleta, José António Pereira Silva, João Eurico Fonseca, and Olena, Zimba.

Subjects
equity, inflammatory myopathies, Keywords: Equity, myositis, rheumatic disease, survey, treatment

14. Vaccine hesitancy decreases, long term concerns remain in myositis, rheumatic disease patients: A comparative analysis of the COVAD surveys

Author

Parikshit, Sen, Naveen, R, Nazanin, Houshmand, Siamak Moghadam Kia, Mrudula, Joshi, Sreoshy, Saha, Kshitij, Jagtap, Vishwesh, Agarwal, Arvind, Nune, Elena, Nikiphorou, Ai Lyn Tan, Samuel Katsuyuki Shinjo, Nelly, Ziade, Tsvetelina, Velikova, Marcin, Milchert, Ioannis, Parodis, Abraham Edgar Gracia-Ramos, Lorenzo, Cavagna, Masataka, Kuwana, Johannes, Knitza, Ashima, Makol, Aarat, Patel, John, D Pauling, Chris, Wincup, Bhupen, Barman, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio García-De La Torre, Iris, J Colunga-Pedraza, Javier, Merayo-Chalico, Okwara Celestine Chibuzo, Wanruchada, Katchamart, Phonpen Akawatcharangura Goo, Russka, Shumnalieva, Yi-Ming, Chen, Leonardo Santos Hoff, Lina El Kibbi, Hussein, Halabi, Binit, Vaidya, Syahrul Sazliyana Shaharir, A T, M Tanveer Hasan, Dzifa, Dey, Carlos Enrique Toro Gutiérrez, Carlo Vinicio Caballero-Uribe, James, B Lilleker, Babur, Salim, Tamer, Gheita, Tulika, Chatterjee, Oliver, Distler, Miguel, A Saavedra, Jessica, Day, Hector, Chinoy, COVAD study group, Vikas, Agarwal, Rohit, Aggarwal, Latika Gupta COVAD Study Group Authors: Sinan Kardes, Andreoli, Laura, Lini, Daniele, Karen, Screiber, Melinda, Nagy, Vince, Yogesh Preet Singh, Rajiv, Ranjan, Avinash, Jain, Sapan, C Pandya, Rakesh Kumar Pilania, Aman, Sharma, Manesh Manoj, M, Vikas, Gupta, Chengappa, G Kavadichanda, Pradeepta Sekhar Patro, Sajal, Ajmani, Sanat, Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha, Shenoy, Ajay, Asranna, Keerthi Talari Bommakanti, Anuj, Shukla, Arunkumar, R Pande, Kunal, Chandwar, Akanksha, Ghodke, Hiya, Boro, Zoha Zahid Fazal, Döndü Üsküdar Cansu, Reşit, Yıldırım, Armen Yuri Gasparyan, Nicoletta Del Papa, Gianluca, Sambataro, Atzeni, Fabiola, Marcello, 4 Govoni, Simone, Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico, Fusaro, Marco, Sebastiani, Quartuccio, Luca, Franceschini, Franco, Pier Paolo Sainaghi, Giovanni, Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo, Venerito, Silvia, Grignaschi, Alessandro, Giollo, Alessia, Alluno, Florenzo, Ioannone, Marco, Fornaro, Lisa, S Traboco, Suryo Anggoro Kusumo Wibowo, Jesús, Loarce-Martos, Sergio, Prieto-González, Raquel Aranega Gonzalez, Akira, Yoshida, Ran, Nakashima, Shinji, Sato, Naoki, Kimura, Yuko, Kaneko, Takahisa, Gono, Stylianos, Tomaras, Fabian Nikolai Proft, Marie-Therese, Holzer, Margarita Aleksandrovna Gromova, Aharonov, Or, Zoltán, Griger, Ihsane 11 Hmamouchi, Imane El bouchti, Zineb, Baba, Margherita, Giannini, François, Maurier, Julien, Campagne, Alain, Meyer, Daman, Langguth, Vidya, Limaye, Merrilee, Needham, Nilesh, Srivastav, Marie, Hudson, Océane, Landon-Cardinal, Wilmer Gerardo Rojas Zuleta, Álvaro, Arbeláez, Javier, Cajas, José, António, Pereira, Silva, João Eurico Fonseca, Olena, Zimba, Doskaliuk, Bohdana, Uyi, Ima-Edomwonyi, Ibukunoluwa, Dedeke, Emorinken, Airenakho, Nwankwo Henry Madu, Abubakar, Yerima, Hakeem, Olaosebikan, Becky, A., Oruma Devi Koussougbo, Elisa, Palalane, Ho, So, Manuel Francisco Ugarte-Gil, Lyn, Chinchay, José Proaño Bernaola, Victorio, Pimentel, Hanan Mohammed Fathi, Reem, Hamdy, Mohammed, A, Ghita, Harifi, Yurilís, Fuentes-Silva, Karoll, Cabriza, Jonathan, Losanto, Nelly, Colaman, Antonio, Cachafeiro-Vilar, Generoso Guerra Bautista, Enrique Julio Giraldo Ho, Raúl, González, Lilith Stange Nunez, Cristian Vergara, M, Jossiell Then Báez, Hugo, Alonzo, Carlos Benito Santiago Pastelin, Rodrigo García Salinas, Alejandro Quiñónez Obiols, Nilmo, Chávez, Andrea Bran Ordóñez, Sandra, Argueta, Gil Alberto Reyes Llerena, Radames, Sierra-Zorita, Dina, Arrieta, Eduardo Romero Hidalgo, Ricardo, Saenz, Idania Escalante, M, Roberto, Morales, Wendy, Calapaqui, Ivonne, Quezada, and Gabriela, Arredondo

Subjects
COVID-19 vaccines, registries, vaccine hesitancy, autoimmune disease, Idiopathic Inflammatory Myopathies

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