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1. Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial

Author

Vitanza, Nicholas A., Ronsley, Rebecca, Choe, Michelle, Seidel, Kristy, Huang, Wenjun, Rawlings-Rhea, Stephanie D., Beam, Madison, Steinmetzer, Leonel, Wilson, Ashley L., Brown, Christopher, Beebe, Adam, Lindgren, Catherine, Gustafson, Joshua A., Wein, Amy, Holtzclaw, Susan, Hoeppner, Corrine, Goldstein, Hannah E., Browd, Samuel R., Hauptman, Jason S., Lee, Amy, Ojemann, Jeffrey G., Crotty, Erin E., Leary, Sarah E. S., Perez, Francisco A., Wright, Jason N., Alonso, Marta M., Dun, Matthew D., Foster, Jessica B., Hurst, Diana, Kong, Ada, Thomsen, Alison, Orentas, Rimas J., Albert, Catherine M., Pinto, Navin, Annesley, Colleen, Gardner, Rebecca A., Ho, On, Pattabhi, Sowmya, Gust, Juliane, Wendler, Jason P., Park, Julie R., and Jensen, Michael C.

Published
2025
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4. A Closer Look at Some Recent Proof Compression-Related Claims

Author

Chavrimootoo, Michael C., Ferland, Ethan, Gibson, Erin, and Wilson, Ashley H.

Subjects
Computer Science - Computational Complexity, Computer Science - Logic in Computer Science
Abstract

Gordeev and Haeusler [GH19] claim that each tautology $\rho$ of minimal propositional logic can be proved with a natural deduction of size polynomial in $|\rho|$. This builds on work from Hudelmaier [Hud93] that found a similar result for intuitionistic propositional logic, but for which only the height of the proof was polynomially bounded, not the overall size. They arrive at this result by transforming a proof in Hudelmaier's sequent calculus into an equivalent tree-like proof in Prawitz's system of natural deduction, and then compressing the tree-like proof into an equivalent DAG-like proof in such a way that a polynomial bound on the height and foundation implies a polynomial bound on the overall size. Our paper, however, observes that this construction was performed only on minimal implicational logic, which we show to be weaker than the minimal propositional logic for which they claim the result (see Section 4.2). Simply extending the logic systems used to cover minimal propositional logic would not be sufficient to recover the results of the paper, as it would entirely disrupt proofs of a number of the theorems that are critical to proving the main result. Relying heavily on their aforementioned work, Gordeev and Haeusler [GH20] claim to establish NP=PSPACE. The argument centrally depends on the polynomial bound on proof size in minimal propositional logic. Since we show that that bound has not been correctly established by them, their purported proof does not correctly establish NP=PSPACE.

Published
2022

5. STRIvE-02: A First-in-Human Phase I Study of Systemically Administered B7-H3 Chimeric Antigen Receptor T Cells for Patients With Relapsed/Refractory Solid Tumors

Author

Pinto, Navin, Albert, Catherine M., Taylor, Mallory R., Ullom, Heidi B., Wilson, Ashley L., Huang, Wenjun, Wendler, Jason, Pattabhi, Sowmya, Seidel, Kristy, Brown, Christopher, Gustafson, Joshua A., Rawlings-Rhea, Stephanie D., Cheeney, Safia H.E., Burleigh, Katelyn, Gustafson, Heather H., Orentas, Rimas J., Vitanza, Nicholas A., Gardner, Rebecca A., Jensen, Michael C., and Park, Julie R.

Published
2024
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6. 2019-20 National Postsecondary Student Aid Study (NPSAS:20): First Look at the Impact of the Coronavirus (COVID-19) Pandemic on Undergraduate Student Enrollment, Housing, and Finances (Preliminary Data). Summary. NCES 2021-456

Author

RTI International, National Center for Education Statistics (NCES) (ED/IES), Cameron, Margaux, Lacy, T. Austin, Siegel, Peter, Wu, Joanna, Wilson, Ashley, Johnson, Ruby, and Wine, Jennifer

Abstract

This Summary highlights the findings from the First Look full report. The findings in this report provide the first national estimates of the COVID-19 pandemic's impact on postsecondary students. Researchers have previously collected and reported data at institution, state, and international levels (Aristovnik et al. 2020; Aucejo et al. 2020; California Student Aid Commission 2020). The full report presents basic findings about undergraduate student experiences during the coronavirus pandemic (referred to in this report as COVID-19) in spring 2020. These findings are based on preliminary data from the 2019-20 National Postsecondary Student Aid Study (NPSAS:20), a national survey of undergraduate and graduate students enrolled any time between July 1, 2019, and June 30, 2020, in institutions that can participate in federal financial aid programs. [For the full report, see ED613348.]

Published
2021

7. 2019-20 National Postsecondary Student Aid Study (NPSAS:20): First Look at the Impact of the Coronavirus (COVID-19) Pandemic on Undergraduate Student Enrollment, Housing, and Finances (Preliminary Data). NCES 2021-456

Author

RTI International, National Center for Education Statistics (NCES) (ED/IES), Cameron, Margaux, Lacy, T. Austin, Siegel, Peter, Wu, Joanna, Wilson, Ashley, Johnson, Ruby, Burns, Rachel, and Wine, Jennifer

Abstract

This First Look report presents basic findings about undergraduate student experiences during COVID-19 in spring 2020. These findings are based on preliminary data from the 2019-20 National Postsecondary Student Aid Study (NPSAS:20), a national survey of undergraduate and graduate students enrolled any time between July 1, 2019, and June 30, 2020, in institutions that can participate in federal financial aid programs. The findings in this report provide the first national estimates of the COVID-19 pandemic's impact on postsecondary students. Researchers have previously collected and reported data at institution, state, and international levels (Aristovnik et al. 2020; Aucejo et al. 2020; California Student Aid Commission 2020). The main purpose of NPSAS:20 is to measure how students and their families pay for postsecondary education at Title IV eligible institutions, with a focus on federal student aid given through Title IV of the Higher Education Act. NPSAS:20 student surveys started in March 2020, just as the pandemic began affecting students' educational experiences. Items about COVID-19 were added in April to collect information about these effects on students between January 1 and June 30, 2020. Because these items were based on effects seen early in the pandemic, they likely do not reflect all possible student experiences. Data used in this report are from 61,000 NPSAS undergraduate respondents who completed the survey after the COVID-19 items were added. Data from students who answered before the COVID-19 items were added are not included; however, the data for those who answered after the items were added are weighted to represent all undergraduates in the United States enrolled between January and June 2020. [For the summary, see ED613349.]

Published
2021

9. SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions

Author

Deng, Qing, Lakra, Priya, Gou, Panhong, Yang, Haopeng, Meydan, Cem, Teater, Matthew, Chin, Christopher, Zhang, Wenchao, Dinh, Tommy, Hussein, Usama, Li, Xubin, Rojas, Estela, Liu, Weiguang, Reville, Patrick K., Kizhakeyil, Atish, Barisic, Darko, Parsons, Sydney, Wilson, Ashley, Henderson, Jared, Scull, Brooks, Gurumurthy, Channabasavaiah, Vega, Francisco, Chadburn, Amy, Cuglievan, Branko, El-Mallawany, Nader Kim, Allen, Carl, Mason, Christopher, Melnick, Ari, and Green, Michael R.

Published
2024
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12. Upregulation versus loss of function of NTRK2 in 44 affected individuals leads to 2 distinct neurodevelopmental disorders

Author

Berger, Eva, Jauss, Robin-Tobias, Ranells, Judith D., Zonic, Emir, von Wintzingerode, Lydia, Wilson, Ashley, Wagner, Johannes, Tuttle, Annabelle, Thomas-Wilson, Amanda, Schulte, Björn, Rabin, Rachel, Pappas, John, Odgis, Jacqueline A., Muthaffar, Osama, Mendez-Fadol, Alejandra, Lynch, Matthew, Levy, Jonathan, Lehalle, Daphné, Lake, Nicole J., Krey, Ilona, Kozenko, Mariya, Knierim, Ellen, Jouret, Guillaume, Jobanputra, Vaidehi, Isidor, Bertrand, Hunt, David, Hsieh, Tzung-Chien, Holtz, Alexander M., Haack, Tobias B., Gold, Nina B., Dunstheimer, Désirée, Donge, Mylène, Deb, Wallid, De La Rosa Poueriet, Katlin A., Danyel, Magdalena, Christodoulou, John, Chopra, Saurabh, Callewaert, Bert, Busche, Andreas, Brick, Lauren, Bigay, Bary G., Arlt, Marie, Anikar, Swathi S., Almohammal, Mohammad N., Almanza, Deanna, Alhashem, Amal, Bertoli-Avella, Aida, Sticht, Heinrich, and Jamra, Rami Abou

Published
2024
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15. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T cells in pediatric acute lymphoblastic leukemia

Author

Masih, Katherine E., Gardner, Rebecca A., Chou, Hsien-Chao, Abdelmaksoud, Abdalla, Song, Young K., Mariani, Luca, Gangalapudi, Vineela, Gryder, Berkley E., Wilson, Ashley L., Adebola, Serifat O., Stanton, Benjamin Z., Wang, Chaoyu, Milewski, David, Kim, Yong Yean, Tian, Meijie, Cheuk, Adam Tai-Chi, Wen, Xinyu, Zhang, Yue, Altan-Bonnet, Grégoire, Kelly, Michael C., Wei, Jun S., Bulyk, Martha L., Jensen, Michael C., Orentas, Rimas J., and Khan, Javed

Published
2023
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19. Development and validation of a multivariable risk factor questionnaire to detect oesophageal cancer in 2-week wait patients

Author

Adu-Anti, Olivia, Alexandropoulou, Kalliopi, Ayub, Ameena, Barnes, Nicky, Basford, Peter, Brown, Ellen, Butterworth, Jeffrey, Button, Heather, Clarke, Ellie, Cope, Alexandra, Cordle, Jessica, Da Rocha, Joana, DeCaestecker, John, Dhar, Anjan, Dunn, Jason, Ebon, Martin, Forsey, Stacey, Foster, Tracy, Gallagher, Edith, Graham, Helen, Gregg, Fiona, Hall, Philip, Jackson, Sandra, Kader, Nicole, Kadri, Sudarshan, Kalsi, Sandhya, Keld, Richard, Lee, Chun, Lee, Hui Yann, Li, Andy CY, Lipman, Gideon, Mainie, Inder, Matthews, Julie, Mendonca, Cheryl, Morris, Danielle, Patel, Vinod, Paterson, Philip, Phillips, Rosemary, Ratcliffe, Elizabeth, Rees, Cait, Rusu, Radu, Savill, Heather, Shetty, Sharan, Sinha, Leena, Soin, Bob, Solkar, Mamoon, Veeramootoo, Darmarajah, Vere, Joanne, Watchorn, Olivia, Wegstapel, Hendrik, White, Tracey, Willert, Robert, Woodrow, Susannah, Zeki, Sebastian, Ho, Kai Man Alexander, Rosenfeld, Avi, Hogan, Áine, McBain, Hazel, Duku, Margaret, Wolfson, Paul BD, Wilson, Ashley, Cheung, Sharon MY, Hennelly, Laura, Macabodbod, Lester, Graham, David G, Sehgal, Vinay, Banerjee, Amitava, and Lovat, Laurence B

Published
2023
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20. Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety

Author

Vitanza, Nicholas A., Ronsley, Rebecca, Choe, Michelle, Henson, Casey, Breedt, Mandy, Barrios-Anderson, Adriel, Wein, Amy, Brown, Christopher, Beebe, Adam, Kong, Ada, Kirkey, Danielle, Lee, Brittany M., Leary, Sarah E.S., Crotty, Erin E., Hoeppner, Corrine, Holtzclaw, Susan, Wilson, Ashley L., Gustafson, Joshua A., Foster, Jessica B., Iliff, Jeffrey J., Goldstein, Hannah E., Browd, Samuel R., Lee, Amy, Ojemann, Jeffrey G., Pinto, Navin, Gust, Juliane, Gardner, Rebecca A., Jensen, Michael C., Hauptman, Jason S., and Park, Julie R.

Published
2023
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22. Rare pathogenic variants in WNK3 cause X-linked intellectual disability

Author

Küry, Sébastien, Zhang, Jinwei, Besnard, Thomas, Caro-Llopis, Alfonso, Zeng, Xue, Robert, Stephanie M., Josiah, Sunday S., Kiziltug, Emre, Denommé-Pichon, Anne-Sophie, Cogné, Benjamin, Kundishora, Adam J., Hao, Le T., Li, Hong, Stevenson, Roger E., Louie, Raymond J., Deb, Wallid, Torti, Erin, Vignard, Virginie, McWalter, Kirsty, Raymond, F. Lucy, Rajabi, Farrah, Ranza, Emmanuelle, Grozeva, Detelina, Coury, Stephanie A., Blanc, Xavier, Brischoux-Boucher, Elise, Keren, Boris, Õunap, Katrin, Reinson, Karit, Ilves, Pilvi, Wentzensen, Ingrid M., Barr, Eileen E., Guihard, Solveig Heide, Charles, Perrine, Seaby, Eleanor G., Monaghan, Kristin G., Rio, Marlène, van Bever, Yolande, van Slegtenhorst, Marjon, Chung, Wendy K., Wilson, Ashley, Quinquis, Delphine, Bréhéret, Flora, Retterer, Kyle, Lindenbaum, Pierre, Scalais, Emmanuel, Rhodes, Lindsay, Stouffs, Katrien, Pereira, Elaine M., Berger, Sara M., Milla, Sarah S., Jaykumar, Ankita B., Cobb, Melanie H., Panchagnula, Shreyas, Duy, Phan Q., Vincent, Marie, Mercier, Sandra, Gilbert-Dussardier, Brigitte, Le Guillou, Xavier, Audebert-Bellanger, Séverine, Odent, Sylvie, Schmitt, Sébastien, Boisseau, Pierre, Bonneau, Dominique, Toutain, Annick, Colin, Estelle, Pasquier, Laurent, Redon, Richard, Bouman, Arjan, Rosenfeld, Jill. A., Friez, Michael J., Pérez-Peña, Helena, Akhtar Rizvi, Syed Raza, Haider, Shozeb, Antonarakis, Stylianos E., Schwartz, Charles E., Martínez, Francisco, Bézieau, Stéphane, Kahle, Kristopher T., and Isidor, Bertrand

Published
2022
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23. Utilization and perceived usefulness of monitoring technology for family caregivers of people living with Alzheimer's disease and related dementias.

Author

Smith, Matthew Lee, Wilson, Ashley D, Knebl, Janice, Hilsabeck, Robin C, Reuter, Kristen, Aguirre, Alyssa, Harty, Barbara, Kew, Chung Lin, Lee, Shinduk, and Ory, Marcia G

Subjects
*BURDEN of care, *ALZHEIMER'S disease, *CAREGIVERS, *MOBILE apps, *TELEPHONE interviewing
Abstract

Background: Caregivers of people living with dementia (PLWD) often experience burden based on their care recipients' symptoms of wandering, disorientation, and agitation. Objective: To examine the utilization and perceived value of technology-based solutions for caregiving among caregivers of PLWD. Methods: In collaboration with three Texas sites, PLWD and family caregiver dyads were recruited from clinical and community sites to assess the feasibility of a caregiving technology. PLWDs were asked to wear a GPS-based wearable device, which was paired with caregivers' smartphone application, that enabled location monitoring and was equipped with call functions. After three months, researchers called caregivers to ask about their utilization of the "system" (i.e., wearable paired with smartphone application) and the perceived value of this technology. Forty-one caregivers completed follow-up telephone interviews. Results: About 70% of caregivers reported their care recipient wore the wearable device daily, and 39.1% used the smartphone application daily. Approximately 31% of caregivers reported daily use of the tracking feature, 30.8% reported daily use of the "safe zone" feature (i.e., geo-fencing), and 17.1% reported daily use of the two-way calling feature. About 39% of caregivers were extremely satisfied with the "system," 43.6% found it extremely easy to use, and 46.2% found it extremely useful for caregiving. On average, caregivers with higher baseline Zarit Burden Interview scores found the "system" to be more useful with their caregiving (f = 5.97, p = 0.006) and were more satisfied with the "system" (f = 3.75, p = 0.034). Conclusions: Findings suggest caregiver burden may drive the perceived usefulness of, and satisfaction with, technology-based solutions. [ABSTRACT FROM AUTHOR]

Published
2025
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25. STRIvE-02 Arm C: Phase 1 study of concurrent PD-1 inhibition with B7-H3 CAR T cell immunotherapy for recurrent/refractory pediatric solid tumors.

Author

Choe, Michelle, primary, Taylor, Mallory, additional, Wendler, Jason, additional, Narayanaswamy, Prabha, additional, Rawlings-Rhea, Stephanie, additional, Seidel, Kristy, additional, Huang, Wenjun, additional, Pattabhi, Sowmya, additional, Gamble, Danielle, additional, Ho, On, additional, Wilson, Ashley, additional, Mgebroff, Stephanie, additional, Brown, Christopher, additional, Lindgren, Catherine, additional, Annesley, Colleen, additional, Gardner, Rebecca Alice, additional, Jensen, Michael, additional, Park, Julie R., additional, Albert, Catherine Michelle, additional, and Pinto, Navin, additional

Published
2024
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26. Ground-based near-UV observations of 15 transiting exoplanets: Constraints on their atmospheres and no evidence for asymmetrical transits

Author

Turner, Jake D., Pearson, Kyle A., Biddle, Lauren I., Smart, Brianna M., Zellem, Robert T., Teske, Johanna K., Hardegree-Ullman, Kevin K., Griffith, Caitlin C., Leiter, Robin M., Cates, Ian T., Nieberding, Megan N., Smith, Carter-Thaxton W., Thompson, Robert M., Hofmann, Ryan, Berube, Michael P., Nguyen, Chi H., Small, Lindsay C., Guvenen, Blythe C., Richardson, Logan, McGraw, Allison, Raphael, Brandon, Crawford, Benjamin E., Robertson, Amy N., Tombleson, Ryan, Carleton, Timothy M., Towner, Allison P. M., Walker-LaFollette, Amanda M., Hume, Jeffrey R., Watson, Zachary T., Jones, Christen K., Lichtenberger, Matthew J., Hoglund, Shelby R., Cook, Kendall L., Crossen, Cory A., Jorgensen, Curtis R., Thompson, James M. Romine Alejandro R., Villegas, Christian F., Wilson, Ashley A., Sanford, Brent, and Taylor, Joanna M.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Transits of exoplanets observed in the near-UV have been used to study the scattering properties of their atmospheres and possible star-planet interactions. We observed the primary transits of 15 exoplanets (CoRoT-1b, GJ436b, HAT-P-1b, HAT-P-13b, HAT-P-16b, HAT-P-22b, TrES-2b, TrES-4b, WASP-1b, WASP-12b, WASP-33b, WASP-36b, WASP-44b, WASP-48b, and WASP-77Ab) in the near-UV and several optical photometric bands to update their planetary parameters, ephemerides, search for a wavelength dependence in their transit depths to constrain their atmospheres, and determine if asymmetries are visible in their light curves. Here we present the first ground-based near-UV light curves for 12 of the targets (CoRoT-1b, GJ436b, HAT-P-1b, HAT-P-13b, HAT-P-22b, TrES-2b, TrES-4b, WASP-1b, WASP-33b, WASP-36b, WASP-48b, and WASP-77Ab). We find that none of the near-UV transits exhibit any non-spherical asymmetries, this result is consistent with recent theoretical predictions by Ben-Jaffel et al. and Turner et al. The multi-wavelength photometry indicates a constant transit depth from near-UV to optical wavelengths in 10 targets (suggestive of clouds), and a varying transit depth with wavelength in 5 targets (hinting at Rayleigh or aerosol scattering in their atmospheres). We also present the first detection of a smaller near-UV transit depth than that measured in the optical in WASP-1b and a possible opacity source that can cause such radius variations is currently unknown. WASP-36b also exhibits a smaller near-UV transit depth at 2.6$\sigma$. Further observations are encouraged to confirm the transit depth variations seen in this study., Comment: 35 pages, 16 tables, 10 figures. Accepted for publication in MNRAS (March 8, 2016). Light curves are available online. Updated EXOMOP (transit modeling software) and is also available online

Published
2016
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27. Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

Author

Vitanza, Nicholas A., Johnson, Adam J., Wilson, Ashley L., Brown, Christopher, Yokoyama, Jason K., Künkele, Annette, and Chang, Cindy A.

Subjects
Diagnosis, Testing, Care and treatment, Development and progression, Health aspects, Pediatric tumors -- Diagnosis -- Development and progression -- Care and treatment, Nervous system tumors -- Diagnosis -- Development and progression -- Care and treatment, T cell antigen receptors -- Health aspects -- Testing, Immunotherapy -- Testing, T cells -- Receptors, Antigen receptors, T cell -- Health aspects -- Testing, Tumors in children -- Diagnosis -- Development and progression -- Care and treatment
Abstract

Author(s): Nicholas A. Vitanza [sup.1] [sup.2] , Adam J. Johnson [sup.1] [sup.3] , Ashley L. Wilson [sup.1] [sup.3] , Christopher Brown [sup.3] [sup.4] , Jason K. Yokoyama [sup.1] [sup.3] , [...], Locoregional delivery of chimeric antigen receptor (CAR) T cells has resulted in objective responses in adults with glioblastoma, but the feasibility and tolerability of this approach is yet to be evaluated for pediatric central nervous system (CNS) tumors. Here we show that engineering of a medium-length CAR spacer enhances the therapeutic efficacy of human erb-b2 receptor tyrosine kinase 2 (HER2)-specific CAR T cells in an orthotopic xenograft medulloblastoma model. We translated these findings into BrainChild-01 (NCT03500991), an ongoing phase 1 clinical trial at Seattle Children's evaluating repetitive locoregional dosing of these HER2-specific CAR T cells to children and young adults with recurrent/refractory CNS tumors, including diffuse midline glioma. Primary objectives are assessing feasibility, safety and tolerability; secondary objectives include assessing CAR T cell distribution and disease response. In the outpatient setting, patients receive infusions via CNS catheter into either the tumor cavity or the ventricular system. The initial three patients experienced no dose-limiting toxicity and exhibited clinical, as well as correlative laboratory, evidence of local CNS immune activation, including high concentrations of CXCL10 and CCL2 in the cerebrospinal fluid. This interim report supports the feasibility of generating HER2-specific CAR T cells for repeated dosing regimens and suggests that their repeated intra-CNS delivery might be well tolerated and activate a localized immune response in pediatric and young adult patients. In an interim analysis of a phase 1 trial, repeated intracranial infusions of HER2-specific CAR T cells were well tolerated with no observed dose-limiting toxicities in three young adult patients with CNS tumors.

Published
2021
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28. "I was very scared when I found out my son had sickle cell": Caregiver knowledge and attitudes toward early intervention for young children with sickle cell disease: Implications for policy and practice from a multi‐site study.

Author

Hoyt, Catherine R., MacArthur, Erin, Leaver, Hayes, Wilson, Ashley L., Davis, Kandace, Harris, Kelly M., Damiano, Riley, Moore, Hunter, Housten, Ashley J., Britts, Rosemary, Hankins, Jane Silva, King, Allison A., and Heitzer, Andrew M.

Published
2024
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29. Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial

Author

Bagewadi, Abhay, Patrick, Abigail, Shenoy, Achuth, Redmond, Aisling, Muddu, Ajay, Northrop, Alex, Groves, Alice, Shiner, Alice, Heer, Amardeep, Takhar, Amrit, Bowles, Amy, Jarman, Andrea, Wong, Angela, Lucas, Angie, Gibbons, Anita, Dhar, Anjan, Curry, Anji, Lalonde, Anna, Swinburn, Anna, Turner, Anne, Lydon, Anne-Marie, Gunstone, Anthony, Lee, Arlene, Nambi, Arul, Ariyarathenam, Arun, Elden, Ashley, Wilson, Ashley, Donepudi, Balaji, Campbell, Barbara, Uszycka, Basia, Bowers, Ben, Coghill, Ben, de Quadros, Bruno, Cheah, Calvin, Bratten, Carla, Brown, Carly, Moorbey, Chantelle, Clisby, Charles, Gordon, Charles, Schramm, Chris, Castle, Chris, Newark, Chris, Norris, Chrissie, A'Court, Christine, Graham, Claire, Fletcher, Clare, Grocott, Clare, Rees, Colin, Bakker, Corinne, Paschalides, Costas, Vickery, Craig, Schembri, Damian, Morris, Danielle, Hagan, Daryl, Cronk, David, Goddard, David, Graham, David, Phillips, Dean, Prabhu, Deeksha, Kejariwal, Deepak, Garg, Dhirendra, Lonsdale, Diane, Butterworth, Dianne, Clements, Donna, Bradman, Drew, Blake, Duncan, Mather, Elizabeth, O'Farrell, Ewan, Markowetz, Florian, Adams, Fran, Pesola, Francesca, Forbes, Gareth, Taylor, Gary, Collins, Glenn, Irvine, Gordon, Fourie, Gysbert, Doyle, Harriet, Barnes, Heather, Bowyer, Helen, Whiting, Helen, Beales, Ian, Binnian, Ian, Bremner, Ian, Jennings, Ian, Troiceanu, Ilona, Modelell, Ines, Emmerson, Ingrid, Ortiz, Jacobo, Lilley, Jacqueline, Harvey, Jacquelyn, Vicars, Jacqui, Takhar, Jagjit, Larcombe, James, Bornschein, Jan, Aldegather, Jehad, Johnson, Jenny, Ducker, Jill, Skinner, Jo, Dash, Joanne, Walsh, Joanne, Miralles, Jose, Ridgway, Josephine, Ince, Julia, Kennedy, Julie, Hampson, Kat, Milne, Kate, Ellerby, Katherine, Priddis, Katherine, Rainsbury, Kathy, Powell, Kelly, Gunner, Kerry, Ragunath, Krish, Knox, Kyle, Baseley, Laura, White, Lauren, Lovat, Laurence, Berney, Lee, Crockett, Lindsay, Murray, Lisa, Westwood, Lisa, Chalkley, Lisa, Leggett, Loraine, Dale, Louise, Scovell, Louise, Brooks, Lucy, Saunders, Lucy, Owen, Lydia, Dilwershah, Maria, Baldry, Marie, Corcoran, Marie, Roy, Marie, Macedo, Mario, Attah, Mark, Anson, Mary-Jo, Rutter, Matt, Wallard, Matthew, Gaw, Matthew, Hunt, Matthew, Lea-Hagerty, Megan, Penacerrada, Melchizedek, Bianchi, Michele, Baker-Moffatt, Michelle, Czajkowski, Michelle, Sleeth, Michelle, Brewer, Nick, Wooding, Nick, Todd, Nicky, Millen, Nicola, Zolle, Olga, Whitehead, Orla, Ojechi, Patrick, Moore, Patrick, Banim, Paul, Spellar, Paula, Bhandari, Pradeep, Kant, Prashant, Nixon, Rachel, Russell, Rebecca, Roberts, Rebekah, Skule, Rene, West, Richard, Fox, Robin, Beesley, Ruth, Gibbins, Ruth, Osborne, Ruth, Thiagarajan, S, Bastiman, Sally, Warburton, Samantha, Pai, Samir, Leith-Russell, Sarah, Utting, Sarah, Watson, Sarah, Wytrykowski, Sarah, Singh, Satish, Malhotra, Shalini, Woods, Sharon, Conway, Shaun, Mateer, Sherrie, Macrae, Shona, Singh, Shruti, Fourie, Simona, Campbell, Siobhan, Parslow-Williams, Siobhan, Goel, Sonica, Dellar, Stephen, Jones, Stephen, Knight, Steve, Mackay-Thomas, Stuart, Mukherjee, Stuti, Allen, Sue, Henry, Suzanne, Evans, Tara, Leighton, Theresa, Bray, Tim, Shackleton, Tom, Santosh, Vanaja, Glover, Vicki, Chandraraj, Vijay, Elson, Will, Briggs, William, Barron, Zoe, Khan, Zohrah, Fitzgerald, Rebecca C, di Pietro, Massimiliano, O'Donovan, Maria, Maroni, Roberta, Muldrew, Beth, Debiram-Beecham, Irene, Gehrung, Marcel, Offman, Judith, Tripathi, Monika, Smith, Samuel G, Aigret, Benoit, Walter, Fiona M, Rubin, Greg, and Sasieni, Peter

Published
2020
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32. Inhibition of MALT1 and BCL2 induces synergistic anti-tumor activity in models of B cell lymphoma

Author

Plotnik, Joshua P., primary, Richardson, Adam E., additional, Yang, Haopeng, additional, Rojas, Estela, additional, Bontcheva, Velitchka, additional, Dowell, Colleen, additional, Parsons, Sydney, additional, Wilson, Ashley, additional, Ravanmehr, Vida, additional, Will, Christine, additional, Jung, Paul, additional, Zhu, Haizhong, additional, Partha, Sarathy Karunan., additional, Panchal, Sanjay C., additional, Mali, Raghuveer Singh, additional, Kohlhapp, Frederick J., additional, McClure, Ryan A., additional, Ramathal, Cyril Y., additional, George, Mariam D., additional, Jhala, Manisha, additional, Elsen, Nathaniel L., additional, Qiu, Wei, additional, Judge, Russell A., additional, Pan, Chin, additional, Mastracchio, Anthony, additional, Henderson, Jared, additional, Meulbroek, Jonathan A., additional, Green, Michael R., additional, and Pappano, William N., additional

Published
2024
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33. Differential protein-protein interactions underlie signaling mediated by the TCR and a 4-1BB domain–containing CAR

Author

Ritmeester-Loy, Samuel A., primary, Draper, Isabella H., additional, Bueter, Eric C., additional, Lautz, Jonathan D., additional, Zhang-Wong, Yue, additional, Gustafson, Joshua A., additional, Wilson, Ashley L., additional, Lin, Chenwei, additional, Gafken, Philip R., additional, Jensen, Michael C., additional, Orentas, Rimas, additional, and Smith, Stephen E. P., additional

Published
2024
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34. Sensory pollutants alter bird phenology and fitness across a continent

Author

Senzaki, Masayuki, Barber, Jesse R., Phillips, Jennifer N., Carter, Neil H., Cooper, Caren B., Ditmer, Mark A., Fristrup, Kurt M., McClure, Christopher J. W., Mennitt, Daniel J., Tyrell, Luke P., Vukomanovic, Jelena, Wilson, Ashley A., and Francis, Clinton D.

Subjects
Physiological aspects, Environmental aspects, Light pollution -- Environmental aspects, Noise pollution -- Environmental aspects, Birds -- Environmental aspects -- Physiological aspects
Abstract

Author(s): Masayuki Senzaki [sup.1] [sup.2] , Jesse R. Barber [sup.3] , Jennifer N. Phillips [sup.1] [sup.4] , Neil H. Carter [sup.5] , Caren B. Cooper [sup.6] [sup.7] , Mark A. [...], Expansion of anthropogenic noise and night lighting across our planet.sup.1,2 is of increasing conservation concern.sup.3-6. Despite growing knowledge of physiological and behavioural responses to these stimuli from single-species and local-scale studies, whether these pollutants affect fitness is less clear, as is how and why species vary in their sensitivity to these anthropic stressors. Here we leverage a large citizen science dataset paired with high-resolution noise and light data from across the contiguous United States to assess how these stimuli affect reproductive success in 142 bird species. We find responses to both sensory pollutants linked to the functional traits and habitat affiliations of species. For example, overall nest success was negatively correlated with noise among birds in closed environments. Species-specific changes in reproductive timing and hatching success in response to noise exposure were explained by vocalization frequency, nesting location and diet. Additionally, increased light-gathering ability of species' eyes was associated with stronger advancements in reproductive timing in response to light exposure, potentially creating phenological mismatches.sup.7. Unexpectedly, better light-gathering ability was linked to reduced clutch failure and increased overall nest success in response to light exposure, raising important questions about how responses to sensory pollutants counteract or exacerbate responses to other aspects of global change, such as climate warming. These findings demonstrate that anthropogenic noise and light can substantially affect breeding bird phenology and fitness, and underscore the need to consider sensory pollutants alongside traditional dimensions of the environment that typically inform biodiversity conservation. Human-generated noise and night lighting affect breeding habits and fitness in birds, implying that sensory pollutants must be considered alongside other environmental factors in assessing biodiversity conservation.

Published
2020
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35. Workshop on the calculation and evaluation of new reference points for category 1–2 stocks (WKNEWREF)

Author

Arge Jacobsen, Jan, Aristegui-Ezquibela, Mikel, Aune, Magnus, Buch, Tanja Baagoe, Bartolino, Valerio, Nord, Mikaela Bergenius, Bogstad, Bjarte, Boje, Jesper, Brooks, Mollie Elizabeth, Brunel, Thomas, Butler, William, Cardinale, Massimiliano, Cerviño, Santiago, Chen, Chun, Rocha, Marta Cousido, De Oliveira, José, Egan, Afra, Elvarsson, Bjarki Thor, Dingsør, Gjert Endre, Fall, Johanna, Farrell, Edward D., Garcia, Dorleta, Gerritsen, Hans, Gilljam, David, Goñi, Nicolas, Griffiths, Christopher, Grossmann, Jenni, Haase, Stefanie, Hintzen, Niels, Holdgate, Alexander Neil, Hommik, Kristiina, Horbowy, Jan, Howell, Daniel, Ibaibarriaga, Leire, Jansen, Teunis, Johannesen, Edda, Kell, Laurence, Kempf, Alexander, Miethe, Tanja, Minto, Cóilín, Albertsen, Christoffer Moesgaard, Nimmegeers, Sofie, Olsen, Hannipoula, Orio, Alessandro, Pawlowski, Lionel, Raitaniemi, Jari, Cruz, Luis Ridao, Rindorf, Anna, Silvar Viladomiu, Paula, Steiner, Noa, Sys, Klaas, Szalaj, Dorota, Taylor, Marc, Tengvall, Jessica, Trijoulet, Vanessa, Uriarte, Andres, Urtizberea, Agurtzane, Mohr Vang, Helga Bára, Vansteenbrugge, Lies, Villanueva, Maria Ching, Walker, Nicola, Wilson, Ashley, Windsland, Kristin, Wise, Laura, Zimmermann, Fabian, Arge Jacobsen, Jan, Aristegui-Ezquibela, Mikel, Aune, Magnus, Buch, Tanja Baagoe, Bartolino, Valerio, Nord, Mikaela Bergenius, Bogstad, Bjarte, Boje, Jesper, Brooks, Mollie Elizabeth, Brunel, Thomas, Butler, William, Cardinale, Massimiliano, Cerviño, Santiago, Chen, Chun, Rocha, Marta Cousido, De Oliveira, José, Egan, Afra, Elvarsson, Bjarki Thor, Dingsør, Gjert Endre, Fall, Johanna, Farrell, Edward D., Garcia, Dorleta, Gerritsen, Hans, Gilljam, David, Goñi, Nicolas, Griffiths, Christopher, Grossmann, Jenni, Haase, Stefanie, Hintzen, Niels, Holdgate, Alexander Neil, Hommik, Kristiina, Horbowy, Jan, Howell, Daniel, Ibaibarriaga, Leire, Jansen, Teunis, Johannesen, Edda, Kell, Laurence, Kempf, Alexander, Miethe, Tanja, Minto, Cóilín, Albertsen, Christoffer Moesgaard, Nimmegeers, Sofie, Olsen, Hannipoula, Orio, Alessandro, Pawlowski, Lionel, Raitaniemi, Jari, Cruz, Luis Ridao, Rindorf, Anna, Silvar Viladomiu, Paula, Steiner, Noa, Sys, Klaas, Szalaj, Dorota, Taylor, Marc, Tengvall, Jessica, Trijoulet, Vanessa, Uriarte, Andres, Urtizberea, Agurtzane, Mohr Vang, Helga Bára, Vansteenbrugge, Lies, Villanueva, Maria Ching, Walker, Nicola, Wilson, Ashley, Windsland, Kristin, Wise, Laura, and Zimmermann, Fabian

Abstract

WKNEWREF is the third workshop of a series of meetings about reference points for category 1 and category 2 stocks being WKREF1 and WKREF2 the preceding ones. The goal of WKNEWREF was to put the recommendations of WKREF2 into practice to identify empirically the strengths and weaknesses of proposed reference points. Ultimately, WKNEWREF should propose alternative definitions or methods to calculate the reference points in the current ICES framework and investigate the use of an Ftarget below FMSY in the ICES advice rule (AR). The workshop had two sets of terms of reference, the first one consisted of the estimation of the stock–recruitment relationship and a set of reference points in a representative group of category 1 and 2 stocks. The second one consisted of the identification of the issues encountered when fitting the stock–recruitment relationship and the strengths and weaknesses of estimated reference points. Reference points were calculated for more than 20 stocks. WKNEWREF made a series of recommendations based on the conducted analysis: • Allee effect: The presence of the Allee effect should be evaluated when defining B lim, particularly when the stock has experienced periods of low stock spawning biomass. Blim should always be set above the Allee effect threshold if it exists and can be estimated. • Regime shifts: Robustness of the ICES AR to changing productivity scenarios should be tested. The research on factors determining the productivity of stocks should continue and on the development of models that account for changes in productivity without the need for truncating time-series. • Stock–recruitment relationship: The current guidelines to define the stock–recruitment relationship should be revised to make them more precise. The sensitivity of the parameters to historical data points should be evaluated before selecting the year range to use for the calculation of reference points.

Published
2024

36. Spliceosome malfunction causes neurodevelopmental disorders with overlapping features

Author

Genetica, Genetica Sectie Research, Cancer, Child Health, Li, Dong, Wang, Qin, Bayat, Allan, Battig, Mark R., Zhou, Yijing, Bosch, Daniëlle G.M., van Haaften, Gijs, Granger, Leslie, Petersen, Andrea K., Pérez-Jurado, Luis A., Aznar-Laín, Gemma, Aneja, Anushree, Hancarova, Miroslava, Bendova, Sarka, Schwarz, Martin, Pourova, Radka Kremlikova, Sedlacek, Zdenek, Keena, Beth A., March, Michael E., Hou, Cuiping, O’Connor, Nora, Bhoj, Elizabeth J., Harr, Margaret H., Lemire, Gabrielle, Boycott, Kym M., Towne, Meghan, Li, Megan, Tarnopolsky, Mark, Brady, Lauren, Parker, Michael J., Faghfoury, Hanna, Parsley, Lea Kristin, Agolini, Emanuele, Dentici, Maria Lisa, Novelli, Antonio, Wright, Meredith, Palmquist, Rachel, Lai, Khanh, Scala, Marcello, Striano, Pasquale, Iacomino, Michele, Zara, Federico, Cooper, Annina, Maarup, Timothy J., Byler, Melissa, Lebel, Robert Roger, Balci, Tugce B., Louie, Raymond, Lyons, Michael, Douglas, Jessica, Nowak, Catherine, Afenjar, Alexandra, Hoyer, Juliane, Keren, Boris, Maas, Saskia M., Motazacker, Mahdi M., Martinez-Agosto, Julian A., Rabani, Ahna M., McCormick, Elizabeth M., Falk, Marni J., Ruggiero, Sarah M., Helbig, Ingo, Møller, Rikke S., Tessarollo, Lino, Ardori, Francesco Tomassoni, Palko, Mary Ellen, Hsieh, Tzung Chien, Krawitz, Peter M., Ganapathi, Mythily, Gelb, Bruce D., Jobanputra, Vaidehi, Wilson, Ashley, Greally, John, Jacquemont, Sébastien, Jizi, Khadijé, Bruel, Ange Line, Quelin, Chloé, Misra, Vinod K., Chick, Erika, Romano, Corrado, Greco, Donatella, Arena, Alessia, Morleo, Manuela, Nigro, Vincenzo, Seyama, Rie, Uchiyama, Yuri, Matsumoto, Naomichi, Taira, Ryoji, Tashiro, Katsuya, Sakai, Yasunari, Yigit, Gökhan, Wollnik, Bernd, Wagner, Michael, Kutsche, Barbara, Hurst, Anna C.E., Thompson, Michelle L., Schmidt, Ryan, Randolph, Linda, Spillmann, Rebecca C., Shashi, Vandana, Higginbotham, Edward J., Cordeiro, Dawn, Carnevale, Amanda, Costain, Gregory, Khan, Tayyaba, Funalot, Benoît, Mau-Them, Frederic Tran, Garcia Moya, Luis Fernandez, García-Miñaúr, Sixto, Osmond, Matthew, Chad, Lauren, Quercia, Nada, Carrasco, Diana, Li, Chumei, Sanchez-Valle, Amarilis, Kelley, Meghan, Nizon, Mathilde, Jensson, Brynjar O., Sulem, Patrick, Stefansson, Kari, Gorokhova, Svetlana, Busa, Tiffany, Rio, Marlène, Habdallah, Hamza Hadj, Lesieur-Sebellin, Marion, Amiel, Jeanne, Pingault, Véronique, Mercier, Sandra, Vincent, Marie, Philippe, Christophe, Fatus-Fauconnier, Clemence, Friend, Kathryn, Halligan, Rebecca K., Biswas, Sunita, Rosser, Jane, Shoubridge, Cheryl, Corbett, Mark, Barnett, Christopher, Gecz, Jozef, Leppig, Kathleen, Slavotinek, Anne, Marcelis, Carlo, Pfundt, Rolph, de Vries, Bert B.A., van Slegtenhorst, Marjon A., Brooks, Alice S., Cogne, Benjamin, Rambaud, Thomas, Tümer, Zeynep, Zackai, Elaine H., Akizu, Naiara, Song, Yuanquan, Hakonarson, Hakon, Genetica, Genetica Sectie Research, Cancer, Child Health, Li, Dong, Wang, Qin, Bayat, Allan, Battig, Mark R., Zhou, Yijing, Bosch, Daniëlle G.M., van Haaften, Gijs, Granger, Leslie, Petersen, Andrea K., Pérez-Jurado, Luis A., Aznar-Laín, Gemma, Aneja, Anushree, Hancarova, Miroslava, Bendova, Sarka, Schwarz, Martin, Pourova, Radka Kremlikova, Sedlacek, Zdenek, Keena, Beth A., March, Michael E., Hou, Cuiping, O’Connor, Nora, Bhoj, Elizabeth J., Harr, Margaret H., Lemire, Gabrielle, Boycott, Kym M., Towne, Meghan, Li, Megan, Tarnopolsky, Mark, Brady, Lauren, Parker, Michael J., Faghfoury, Hanna, Parsley, Lea Kristin, Agolini, Emanuele, Dentici, Maria Lisa, Novelli, Antonio, Wright, Meredith, Palmquist, Rachel, Lai, Khanh, Scala, Marcello, Striano, Pasquale, Iacomino, Michele, Zara, Federico, Cooper, Annina, Maarup, Timothy J., Byler, Melissa, Lebel, Robert Roger, Balci, Tugce B., Louie, Raymond, Lyons, Michael, Douglas, Jessica, Nowak, Catherine, Afenjar, Alexandra, Hoyer, Juliane, Keren, Boris, Maas, Saskia M., Motazacker, Mahdi M., Martinez-Agosto, Julian A., Rabani, Ahna M., McCormick, Elizabeth M., Falk, Marni J., Ruggiero, Sarah M., Helbig, Ingo, Møller, Rikke S., Tessarollo, Lino, Ardori, Francesco Tomassoni, Palko, Mary Ellen, Hsieh, Tzung Chien, Krawitz, Peter M., Ganapathi, Mythily, Gelb, Bruce D., Jobanputra, Vaidehi, Wilson, Ashley, Greally, John, Jacquemont, Sébastien, Jizi, Khadijé, Bruel, Ange Line, Quelin, Chloé, Misra, Vinod K., Chick, Erika, Romano, Corrado, Greco, Donatella, Arena, Alessia, Morleo, Manuela, Nigro, Vincenzo, Seyama, Rie, Uchiyama, Yuri, Matsumoto, Naomichi, Taira, Ryoji, Tashiro, Katsuya, Sakai, Yasunari, Yigit, Gökhan, Wollnik, Bernd, Wagner, Michael, Kutsche, Barbara, Hurst, Anna C.E., Thompson, Michelle L., Schmidt, Ryan, Randolph, Linda, Spillmann, Rebecca C., Shashi, Vandana, Higginbotham, Edward J., Cordeiro, Dawn, Carnevale, Amanda, Costain, Gregory, Khan, Tayyaba, Funalot, Benoît, Mau-Them, Frederic Tran, Garcia Moya, Luis Fernandez, García-Miñaúr, Sixto, Osmond, Matthew, Chad, Lauren, Quercia, Nada, Carrasco, Diana, Li, Chumei, Sanchez-Valle, Amarilis, Kelley, Meghan, Nizon, Mathilde, Jensson, Brynjar O., Sulem, Patrick, Stefansson, Kari, Gorokhova, Svetlana, Busa, Tiffany, Rio, Marlène, Habdallah, Hamza Hadj, Lesieur-Sebellin, Marion, Amiel, Jeanne, Pingault, Véronique, Mercier, Sandra, Vincent, Marie, Philippe, Christophe, Fatus-Fauconnier, Clemence, Friend, Kathryn, Halligan, Rebecca K., Biswas, Sunita, Rosser, Jane, Shoubridge, Cheryl, Corbett, Mark, Barnett, Christopher, Gecz, Jozef, Leppig, Kathleen, Slavotinek, Anne, Marcelis, Carlo, Pfundt, Rolph, de Vries, Bert B.A., van Slegtenhorst, Marjon A., Brooks, Alice S., Cogne, Benjamin, Rambaud, Thomas, Tümer, Zeynep, Zackai, Elaine H., Akizu, Naiara, Song, Yuanquan, and Hakonarson, Hakon

Published
2024

37. Spliceosome malfunction causes neurodevelopmental disorders with overlapping features

Author

Li, Dong, Wang, Qin, Bayat, Allan, Battig, Mark R., Zhou, Yijing, Bosch, Daniëlle G.M., van Haaften, Gijs, Granger, Leslie, Petersen, Andrea K., Pérez-Jurado, Luis A., Aznar-Laín, Gemma, Aneja, Anushree, Hancarova, Miroslava, Bendova, Sarka, Schwarz, Martin, Pourova, Radka Kremlikova, Sedlacek, Zdenek, Keena, Beth A., March, Michael E., Hou, Cuiping, O’Connor, Nora, Bhoj, Elizabeth J., Harr, Margaret H., Lemire, Gabrielle, Boycott, Kym M., Towne, Meghan, Li, Megan, Tarnopolsky, Mark, Brady, Lauren, Parker, Michael J., Faghfoury, Hanna, Parsley, Lea Kristin, Agolini, Emanuele, Dentici, Maria Lisa, Novelli, Antonio, Wright, Meredith, Palmquist, Rachel, Lai, Khanh, Scala, Marcello, Striano, Pasquale, Iacomino, Michele, Zara, Federico, Cooper, Annina, Maarup, Timothy J., Byler, Melissa, Lebel, Robert Roger, Balci, Tugce B., Louie, Raymond, Lyons, Michael, Douglas, Jessica, Nowak, Catherine, Afenjar, Alexandra, Hoyer, Juliane, Keren, Boris, Maas, Saskia M., Motazacker, Mahdi M., Martinez-Agosto, Julian A., Rabani, Ahna M., McCormick, Elizabeth M., Falk, Marni J., Ruggiero, Sarah M., Helbig, Ingo, Møller, Rikke S., Tessarollo, Lino, Ardori, Francesco Tomassoni, Palko, Mary Ellen, Hsieh, Tzung Chien, Krawitz, Peter M., Ganapathi, Mythily, Gelb, Bruce D., Jobanputra, Vaidehi, Wilson, Ashley, Greally, John, Jacquemont, Sébastien, Jizi, Khadijé, Bruel, Ange Line, Quelin, Chloé, Misra, Vinod K., Chick, Erika, Romano, Corrado, Greco, Donatella, Arena, Alessia, Morleo, Manuela, Nigro, Vincenzo, Seyama, Rie, Uchiyama, Yuri, Matsumoto, Naomichi, Taira, Ryoji, Tashiro, Katsuya, Sakai, Yasunari, Yigit, Gökhan, Wollnik, Bernd, Wagner, Michael, Kutsche, Barbara, Hurst, Anna C.E., Thompson, Michelle L., Schmidt, Ryan, Randolph, Linda, Spillmann, Rebecca C., Shashi, Vandana, Higginbotham, Edward J., Cordeiro, Dawn, Carnevale, Amanda, Costain, Gregory, Khan, Tayyaba, Funalot, Benoît, Mau-Them, Frederic Tran, Garcia Moya, Luis Fernandez, García-Miñaúr, Sixto, Osmond, Matthew, Chad, Lauren, Quercia, Nada, Carrasco, Diana, Li, Chumei, Sanchez-Valle, Amarilis, Kelley, Meghan, Nizon, Mathilde, Jensson, Brynjar O., Sulem, Patrick, Stefansson, Kari, Gorokhova, Svetlana, Busa, Tiffany, Rio, Marlène, Habdallah, Hamza Hadj, Lesieur-Sebellin, Marion, Amiel, Jeanne, Pingault, Véronique, Mercier, Sandra, Vincent, Marie, Philippe, Christophe, Fatus-Fauconnier, Clemence, Friend, Kathryn, Halligan, Rebecca K., Biswas, Sunita, Rosser, Jane, Shoubridge, Cheryl, Corbett, Mark, Barnett, Christopher, Gecz, Jozef, Leppig, Kathleen, Slavotinek, Anne, Marcelis, Carlo, Pfundt, Rolph, de Vries, Bert B.A., van Slegtenhorst, Marjon A., Brooks, Alice S., Cogne, Benjamin, Rambaud, Thomas, Tümer, Zeynep, Zackai, Elaine H., Akizu, Naiara, Song, Yuanquan, Hakonarson, Hakon, Li, Dong, Wang, Qin, Bayat, Allan, Battig, Mark R., Zhou, Yijing, Bosch, Daniëlle G.M., van Haaften, Gijs, Granger, Leslie, Petersen, Andrea K., Pérez-Jurado, Luis A., Aznar-Laín, Gemma, Aneja, Anushree, Hancarova, Miroslava, Bendova, Sarka, Schwarz, Martin, Pourova, Radka Kremlikova, Sedlacek, Zdenek, Keena, Beth A., March, Michael E., Hou, Cuiping, O’Connor, Nora, Bhoj, Elizabeth J., Harr, Margaret H., Lemire, Gabrielle, Boycott, Kym M., Towne, Meghan, Li, Megan, Tarnopolsky, Mark, Brady, Lauren, Parker, Michael J., Faghfoury, Hanna, Parsley, Lea Kristin, Agolini, Emanuele, Dentici, Maria Lisa, Novelli, Antonio, Wright, Meredith, Palmquist, Rachel, Lai, Khanh, Scala, Marcello, Striano, Pasquale, Iacomino, Michele, Zara, Federico, Cooper, Annina, Maarup, Timothy J., Byler, Melissa, Lebel, Robert Roger, Balci, Tugce B., Louie, Raymond, Lyons, Michael, Douglas, Jessica, Nowak, Catherine, Afenjar, Alexandra, Hoyer, Juliane, Keren, Boris, Maas, Saskia M., Motazacker, Mahdi M., Martinez-Agosto, Julian A., Rabani, Ahna M., McCormick, Elizabeth M., Falk, Marni J., Ruggiero, Sarah M., Helbig, Ingo, Møller, Rikke S., Tessarollo, Lino, Ardori, Francesco Tomassoni, Palko, Mary Ellen, Hsieh, Tzung Chien, Krawitz, Peter M., Ganapathi, Mythily, Gelb, Bruce D., Jobanputra, Vaidehi, Wilson, Ashley, Greally, John, Jacquemont, Sébastien, Jizi, Khadijé, Bruel, Ange Line, Quelin, Chloé, Misra, Vinod K., Chick, Erika, Romano, Corrado, Greco, Donatella, Arena, Alessia, Morleo, Manuela, Nigro, Vincenzo, Seyama, Rie, Uchiyama, Yuri, Matsumoto, Naomichi, Taira, Ryoji, Tashiro, Katsuya, Sakai, Yasunari, Yigit, Gökhan, Wollnik, Bernd, Wagner, Michael, Kutsche, Barbara, Hurst, Anna C.E., Thompson, Michelle L., Schmidt, Ryan, Randolph, Linda, Spillmann, Rebecca C., Shashi, Vandana, Higginbotham, Edward J., Cordeiro, Dawn, Carnevale, Amanda, Costain, Gregory, Khan, Tayyaba, Funalot, Benoît, Mau-Them, Frederic Tran, Garcia Moya, Luis Fernandez, García-Miñaúr, Sixto, Osmond, Matthew, Chad, Lauren, Quercia, Nada, Carrasco, Diana, Li, Chumei, Sanchez-Valle, Amarilis, Kelley, Meghan, Nizon, Mathilde, Jensson, Brynjar O., Sulem, Patrick, Stefansson, Kari, Gorokhova, Svetlana, Busa, Tiffany, Rio, Marlène, Habdallah, Hamza Hadj, Lesieur-Sebellin, Marion, Amiel, Jeanne, Pingault, Véronique, Mercier, Sandra, Vincent, Marie, Philippe, Christophe, Fatus-Fauconnier, Clemence, Friend, Kathryn, Halligan, Rebecca K., Biswas, Sunita, Rosser, Jane, Shoubridge, Cheryl, Corbett, Mark, Barnett, Christopher, Gecz, Jozef, Leppig, Kathleen, Slavotinek, Anne, Marcelis, Carlo, Pfundt, Rolph, de Vries, Bert B.A., van Slegtenhorst, Marjon A., Brooks, Alice S., Cogne, Benjamin, Rambaud, Thomas, Tümer, Zeynep, Zackai, Elaine H., Akizu, Naiara, Song, Yuanquan, and Hakonarson, Hakon

Abstract

Pre-mRNA splicing is a highly coordinated process. While its dysregulation has been linked to neurological deficits, our understanding of the underlying molecular and cellular mechanisms remains limited. We implicated pathogenic variants in U2AF2 and PRPF19, encoding spliceosome subunits in neurodevelopmental disorders (NDDs), by identifying 46 unrelated individuals with 23 de novo U2AF2 missense variants (including 7 recurrent variants in 30 individuals) and 6 individuals with de novo PRPF19 variants. Eight U2AF2 variants dysregulated splicing of a model substrate. Neuritogenesis was reduced in human neurons differentiated from human pluripotent stem cells carrying two U2AF2 hyper-recurrent variants. Neural loss of function (LoF) of the Drosophila orthologs U2af50 and Prp19 led to lethality, abnormal mushroom body (MB) patterning, and social deficits, which were differentially rescued by wild-type and mutant U2AF2 or PRPF19. Transcriptome profiling revealed splicing substrates or effectors (including Rbfox1, a third splicing factor), which rescued MB defects in U2af50deficient flies. Upon reanalysis of negative clinical exomes followed by data sharing, we further identified 6 patients with NDD who carried RBFOX1 missense variants which, by in vitro testing, showed LoF. Our study implicates 3 splicing factors as NDD-causative genes and establishes a genetic network with hierarchy underlying human brain development and function.

Published
2024

38. Workshop on Implementation of Stakeholder Engagement Strategy (WKSTIMP)

Author

Ballesteros, Marta, Casáis Boo, María José, Casal Ribeiro, Morgan, Chevallier, Adrien, Clay, Patricia, Dengbol, Poul, Dickey Collas, Mark, Farrell, Edward, Fernández Beltrán, José Manuel, Gamaza, María Ángeles, Glyki, Eirini, Haynie, Alan, Henneveux, Aurélien, Hegland, Troels Jacob, Kenny, Andrew, Kraan, Marloes, Köpse, Vera, Minkkinen, Terhi, O´Donoghue, Sean, Pedreschi, Debbi, Rodríguez, Alexandre, Sá Couto, Joana, Sandell, Jane, Schmidt, Jörn, Seixas, Sónia, Sverdrup, Esben, Talevska, Tamara, Van der Meeren, Gro, Wilson, Ashley, Ballesteros, Marta, Casáis Boo, María José, Casal Ribeiro, Morgan, Chevallier, Adrien, Clay, Patricia, Dengbol, Poul, Dickey Collas, Mark, Farrell, Edward, Fernández Beltrán, José Manuel, Gamaza, María Ángeles, Glyki, Eirini, Haynie, Alan, Henneveux, Aurélien, Hegland, Troels Jacob, Kenny, Andrew, Kraan, Marloes, Köpse, Vera, Minkkinen, Terhi, O´Donoghue, Sean, Pedreschi, Debbi, Rodríguez, Alexandre, Sá Couto, Joana, Sandell, Jane, Schmidt, Jörn, Seixas, Sónia, Sverdrup, Esben, Talevska, Tamara, Van der Meeren, Gro, and Wilson, Ashley

Abstract

WKSTIMP supports the ICES Stakeholder Engagement Strategy, through drafting elements for ICES Implementation Plan. The report defines a suit of actions to make the ICES Strategy work. If implemented successfully, a diverse and representative pool of competent, reliable and committed stakeholders will engage with ICES. All stakeholders will be able to contribute effectively based on a clear understanding of the process and what is expected from them. ICES will become a natural place for stakeholders to engage and collaborate, delivering better science and advice by integrating essential knowledge and providing arenas for meaningful dialogues. And, the engagement process will be fully traceable, and its monitoring and evaluation outcomes inform decision-making and organizational learning. The WKSTIMP participants represented a plurality of profiles and backgrounds including natural and social scientists, representatives from the fisheries sector, NGOs, Advisory Councils, ICES Head of SCICOM and ACOM and ICES staff. The analysis and reflective thinking on the Strategy set the basis for exploring actions within the ICES system (Expert Groups, Advice Drafting Groups, MIACO and MIRIA meetings) and across topics (research ethics, data protection, informed consent, conflicts of interest, transparency). The discussion in WKSTIMP highlighted the centrality of stakeholders as data, information and knowledge providers, and highlighted how two complementary ICES initiatives reinforce the Strategy: firstly, the development of guidelines for ensuring the integrity of scientific information submitted to ICES by data providers (e.g., WKENSURE); and secondly, the accountability for fishers and other stakeholders’ perceptions (forthcoming Workshop on perceptions on the dynamics of fish stocks in ICES advice, WKAFPA). Furthermore, participants discussed risks associated with opportunistic behaviour in the engagement processes (creative and created blindness and advice shopping), tailor

Published
2024

39. Benchmark workshop on sandeel (ammodytes spp.) (Outputs from 2022 and 2023 meetings) (WKSANDEEL)

Author

Bartolino, Valerio, Bekkevold, Dorte, Brazier, Aaron, Brooks, Mollie Elizabeth, Davies, Julie Olivia, van Deurs, Mikael, Dingsør, Gjert Endre, Egan, Afra, Håkansson, Kirsten Birch, Henriksen, Ole, Hinchcliffe, James, Hintzen, Niels, Hüssy, Karin, Huwer, Bastian, Jacobsen, Nis Sand, Johnsen, Espen, Kiær, Christian Mathias Rohde, Kvamme, Cecilie, Juul Larsen, Jesper, Lund, Henrik S., Jimenez-Mena, Belen, Mosegaard, Henrik, Olesen, Hans Jakob, Pedersen, Søren Anker, Regnier, Thomas, Rindorf, Anna, Schuchert, Pia, Schueller, Amy, Sparrevohn, Claus Reedtz, Steadman, Daniel, Viksåland, Helge, Walker, Nicola, Walmsley, Suzannah, Berg, Casper Willestofte, Wilson, Ashley, Bartolino, Valerio, Bekkevold, Dorte, Brazier, Aaron, Brooks, Mollie Elizabeth, Davies, Julie Olivia, van Deurs, Mikael, Dingsør, Gjert Endre, Egan, Afra, Håkansson, Kirsten Birch, Henriksen, Ole, Hinchcliffe, James, Hintzen, Niels, Hüssy, Karin, Huwer, Bastian, Jacobsen, Nis Sand, Johnsen, Espen, Kiær, Christian Mathias Rohde, Kvamme, Cecilie, Juul Larsen, Jesper, Lund, Henrik S., Jimenez-Mena, Belen, Mosegaard, Henrik, Olesen, Hans Jakob, Pedersen, Søren Anker, Regnier, Thomas, Rindorf, Anna, Schuchert, Pia, Schueller, Amy, Sparrevohn, Claus Reedtz, Steadman, Daniel, Viksåland, Helge, Walker, Nicola, Walmsley, Suzannah, Berg, Casper Willestofte, and Wilson, Ashley

Abstract

The Benchmark Workshop on Sandeel (Ammodytes spp.) (WKSandeel) was conducted over an extended period, spanning 2021-2023, to agree the assessment methodology to be used in future update assessments of sandeel in areas 1–4 (Figure 1). The benchmark had a strong focus on investigating spatial stock boundaries within the North Sea, bringing catch and survey data compilation and standardization up to standard with the latest insights in ICES and updating the assessments accordingly. The data compilation workshop was preceded by several informal sessions to present the latest findings from an extensive study on stock structure identification, including tagging, otolith micro-chemistry, drift modelling and genetics research. The workshop proposed two alternative stock structure delineation scenarios as presented in Figure 2. The different research projects provided contrasting views on appropriate stock structure delineation, with evidence for residence within the delineated sandeel areas but also migration across the a and b borders as denoted in Figure 2. The group reached consensus that, as a pragmatic way forward, only scenario WKSAND2022a would be put forward for evaluation in the assessments, together with the existing WKSAND2016 delineation as a baseline. Catch numbers at age, fishing effort, maturity at age, weight at age, natural mortality at age and survey indices were recalculated based on the latest insights and tools provided through the ICES RDBES and statistical standardization. Key to this process was also the re-definition of sandeel banks, which are used directly to derive standardized survey indices for the different assessments (Figure 3). For all four sandeel areas, updated assessments were prepared for the WKSAND2022a and WKSAND2016 (baseline) area delineation scenarios. There is no change in area delineation for area 4 under both scenarios. Diagnostics on catch and survey residuals, parameter uncertainty

Published
2024

40. Why conservation biology can benefit from sensory ecology

Author

Dominoni, Davide M., Halfwerk, Wouter, Baird, Emily, Buxton, Rachel T., Fernández-Juricic, Esteban, Fristrup, Kurt M., McKenna, Megan F., Mennitt, Daniel J., Perkin, Elizabeth K., Seymoure, Brett M., Stoner, David C., Tennessen, Jennifer B., Toth, Cory A., Tyrrell, Luke P., Wilson, Ashley, Francis, Clinton D., Carter, Neil H., and Barber, Jesse R.

Published
2020
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41. Flipped Learning: Embedding Questions in Videos

Author

Lim, Kien H. and Wilson, Ashley D.

Abstract

More teachers are trying out the flipped classroom model in which content is delivered outside of class time, typically through online videos and "homework," and follow-up activities are done in class. This model frees up more class time for inquiry and discussion. This article focuses on the self-learning portion of the flipped learning model, in particular, increasing students' intellectual engagement by requiring them to answer embedded questions as they watch math videos. Questions can be embedded to help students gain different types of knowledge. On the basis of a preliminary analysis of 89 embedded questions in 21 videos on geometry and measurement, five types of embedded questions have been identified: (1) factual knowledge; (2) procedural knowledge and skills; (3) conceptual knowledge; (4) task comprehension; and (5) mathematical thinking. An awareness of various pedagogical reasons for embedding a question can expand teachers' repertoire of the kinds of questions they can consider embedding should they wish to assign math videos for their students to watch, especially in a flipped learning model.

Published
2018

43. Near-UV and optical observations of the transiting exoplanet TrES-3b

Author

Turner, Jake D., Smart, Brianna M., Hardegree-Ullman, Kevin K., Carleton, Timothy M., Walker-LaFollette, Amanda M., Crawford, Benjamin E., Smith, Carter-Thaxton W., McGraw, Allison M., Small, Lindsay C., Rocchetto, Marco, Cunningham, Kathryn I., Towner, Allison P. M., Zellem, Robert, Robertson, Amy N., Guvenen, Blythe C., Schwarz, Kamber R., Hardegree-Ullman, Emily E., Collura, Daniel, Henz, Triana N., Lejoly, Cassandra, Richardson, Logan L., Weinand, Michael A., Taylor, Joanna M., Daugherty, Michael J., Wilson, Ashley A., and Austin, Carmen L.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We observed nine primary transits of the hot Jupiter TrES-3b in several optical and near-UV photometric bands from 2009 June to 2012 April in an attempt to detect its magnetic field. Vidotto, Jardine and Helling suggest that the magnetic field of TrES-3b can be constrained if its near-UV light curve shows an early ingress compared to its optical light curve, while its egress remains unaffected. Predicted magnetic field strengths of Jupiter-like planets should range between 8 G and 30 G. Using these magnetic field values and an assumed B_star of 100 G, the Vidotto et al. method predicts a timing difference of 5-11 min. We did not detect an early ingress in our three nights of near-UV observations, despite an average cadence of 68 s and an average photometric precision of 3.7 mmag. However, we determined an upper limit of TrES-3b's magnetic field strength to range between 0.013 and 1.3 G (for a 1-100 G magnetic field strength range for the host star, TrES-3) using a timing difference of 138 s derived from the Nyquist-Shannon sampling theorem. To verify our results of an abnormally small magnetic field strength for TrES-3b and to further constrain the techniques of Vidotto et al., we propose future observations of TrES-3b with other platforms capable of achieving a shorter near-UV cadence. We also present a refinement of the physical parameters of TrES-3b, an updated ephemeris and its first published near-UV light curve. We find that the near-UV planetary radius of Rp = 1.386+0.248-0.144 RJup is consistent with the planet's optical radius., Comment: Accepted for Publication in Monthly Notices of the Royal Astronomical Society (2012 September 21). 13 pages, 5 figures

Published
2012
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44. First-in-human comparison of second- versus third-generation L1CAM-specific CAR T cells in patients with primary refractory or relapsed neuroblastoma

Author

Pinto, Navin, primary, Künkele, Annette, additional, Albert, Catherine, additional, Taylor, Mallory, additional, Ullom, Heidi, additional, Wilson, Ashley, additional, Huang, Wenjun, additional, Wendler, Jason, additional, Seidel, Kristy, additional, Brown, Christopher, additional, Gustafson, Joshua, additional, Rawlings-Rhea, Stephanie, additional, Beebe, Adam, additional, Mgebroff, Stephanie, additional, Gardner, Rebecca, additional, Jensen, Michael, additional, and Park, Julie, additional

Published
2024
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45. 86 Genome sequencing as a first-tier prenatal diagnostic test: Is it time to change?

Author

Jobanputra, Vaidehi, primary, Giordano, Jessica L., additional, Pervola, Josie, additional, Okur, Volkan, additional, Thomas-Wilson, Amanda, additional, Guha, Saurav, additional, Rehman, Atteeq U., additional, Wilson, Ashley, additional, Tinfow, Alexandra, additional, Galloway, Stephanie, additional, Abhyankar, Avinash, additional, Felice, Vanessa, additional, Esteves, Cecilia, additional, Hegedus, Endre, additional, Phadke, Shruti, additional, Srinivasa, Sowmya Thirumalai, additional, Khan, Shahid Y., additional, Nava, Caroline, additional, Yan, Qi, additional, Levy, Brynn, additional, and Wapner, Ronald J., additional

Published
2024
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46. Locoregional CAR T Cells for the Treatment of CNS Tumors in Children: Investigational Drug Service Pharmacy Activities.

Author

Vitanza, Nicholas A., Choe, Michelle, Brown, Christopher, Beebe, Adam, Kong, Ada, Rogers, Lisa, Jacob, Susan, Mano, Elena, Abuan, Kimberly, Mgebroff, Stephanie, Lindgren, Catherine, Gustafson, Joshua A., Wilson, Ashley L., Noll, Alyssa, Ronsley, Rebecca, Crotty, Erin E., Leary, Sarah E. S., Foster, Jessica B., Pinto, Navin, and Gust, Juliane

Subjects
T cells, CHIMERIC antigen receptors, TUMORS in children, CENTRAL nervous system, BRAIN tumors
Abstract

BACKGROUND: A major obstacle in translating the therapeutic potential of chimeric antigen receptor (CAR) T cells to children with central nervous system (CNS) tumors is the blood–brain barrier. To overcome this limitation, preclinical and clinical studies have supported the use of repeated, locoregional intracranial CAR T-cell delivery. However, there is limited literature available describing the process for the involvement of an investigational drug service (IDS) pharmacy, particularly in the setting of a children’s hospital with outpatient dosing for CNS tumors. OBJECTIVES: To describe Seattle Children’s Hospital’s experience in clinically producing CAR T cells and the implementation of IDS pharmacy practices used to deliver more than 300 intracranial CAR T-cell doses to children, as well as to share how we refined the processing techniques from CAR T-cell generation to the thawing of fractionated doses for intracranial delivery. METHODS: Autologous CD4+ and CD8+ T cells were collected and transduced to express HER2, EGFR, or B7-H3–specific CAR T cells. Cryopreserved CAR T cells were thawed by the IDS pharmacy before intracranial delivery to patients with recurrent/refractory CNS tumors or with diffuse intrinsic pontine glioma/diffuse midline glioma. RESULTS: The use of a thaw-and-dilute procedure for cryopreserved individual CAR T-cell doses provides reliable viability and is more efficient than typical thaw-and-wash protocols. Cell viability with the thaw-and-dilute protocol was approximately 75% and was always within 10% of the viability assessed at cryopreservation. Cell viability was preserved through 6 hours after thawing, which exceeded the 1-hour time frame from thawing to infusion. CONCLUSION: As the field of adoptive immunotherapy grows and continues to bring hope to patients with fatal CNS malignancies, it is critical to focus on improving the preparatory steps for CAR T-cell delivery. [ABSTRACT FROM AUTHOR]

Published
2024

49. The Associations between Social-Media Use and Academic Performance among Undergraduate Students in Biology

Author

Leyrer-Jackson, Jonna M. and Wilson, Ashley K.

Abstract

Recent studies have been conducted in regards to the use of social- media by students and how it can impact his/her academic performance. However, much of this research has been focused on how to use social-media websites in the classroom to facilitate student learning. Therefore, we aimed to address how the use of social-media can be either beneficial or detrimental to undergraduate students, with respect to their academic performance. We distributed a survey to 234 participants, all attending the same four-year university. Throughout the survey, the students self-reported their grade point average (GPA), study habits, and social-media use. We established that female students use social-media websites more often than their male peers, and using a Pearson's correlation, we found that GPA negatively correlated with the number of social-media websites to which students subscribe (p < 0.05). Furthermore, we found that using more social-media websites correlated positively with the amount of time students spend using social-media platforms on a daily basis. Although previous studies indicate that social-media websites should be incorporated into the classroom, our results suggest that this addition may have negative effects on the study habits and academic performance of undergraduate students, particularly those within the field of biological sciences.

Published
2018
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