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3. Impact of cytomegalovirus (CMV) seroconversion pre‐allogeneic hematopoietic cell transplantation on posttransplant outcomes.

Author

Sayyed, Ayman, Wilson, Leeann, Stavi, Vered, Chen, Shiyi, Chen, Carol, Mattsson, Jonas, Lipton, Jeffrey H., Kim, Dennis D., Viswabandya, Auro, Kumar, Rajat, Lam, Wilson, Law, Arjun D., Gerbitz, Armin, Pasic, Ivan, Novitzky‐Basso, Igor, Mazzulli, Tony, and Michelis, Fotios V.

Subjects
*HEMATOPOIETIC stem cell transplantation, *STEM cell transplantation, *IMMUNOGLOBULIN M, *IMMUNOGLOBULIN G, *SEROCONVERSION, *HIV seroconversion
Abstract

Cytomegalovirus (CMV) reactivation post‐allogeneic hematopoietic cell transplantation (post‐alloHCT) increases morbidity and mortality. We sought to determine the frequency of CMV seroconversion in patients pre‐alloHCT and to investigate the impact on posttransplant outcomes. We retrospectively investigated 752 adult patients who underwent alloHCT at our center from January 2015 to February 2020 before the adoption of letermovir prophylaxis. CMV serology was assessed at consult and pretransplant. The cohort was divided into four groups based on pretransplant CMV seroconversion: negative to positive (Group 1), positive to negative (Group 2), consistently negative (Group 3), and consistently positive (Group 4). Eighty‐nine patients (12%) had seroconverted from negative to positive, 17 (2%) from positive to negative, 151 (20%) were consistently seronegative, and 495 (66%) were consistently seropositive pretransplant. For the four CMV serostatus groups, cumulative incidence of CMV reactivation at 6 months posttransplant was 4.5%, 47.1%, 6.6%, and 76.6% for Groups 1, 2, 3, and 4, respectively (p <.0001). No differences between groups were seen regarding Grade III–IV acute graft‐versus‐host disease (GVHD) (p =.91), moderate/severe chronic GVHD (p =.41), or graft failure (p =.28). On multivariable analysis, there was no impact of CMV serostatus group on overall survival (p =.67), cumulative incidence of relapse (p =.83) or non‐relapse mortality. alloHCT patients who demonstrate CMV seroconversion pretransplant from negative to positive have a very low risk of CMV reactivation posttransplant. The observed seroconversion may be due to passive CMV immunity acquired through blood products. Quantitative CMV immunoglobulin G/immunoglobulin M pretransplant may help differentiate between true seroconversion and passively transmitted CMV immunoglobulin. [ABSTRACT FROM AUTHOR]

Published
2024
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5. HCT Frailty Scale for Younger and Older Adults Undergoing Allogeneic Hematopoietic Cell Transplantation

Author

Kumar, Rajat, primary, Salas, Maria, additional, Atenafu, Eshetu, additional, Pasic, Ivan, additional, Bascom, Ora, additional, Wilson, Leeann, additional, Lam, Wilson, additional, Law, Arjun, additional, Chen, Carol, additional, Novitzky-Basso, Igor, additional, Kim, Dennis, additional, Gerbitz, Armin, additional, Viswabandya, Auro, additional, Michelis, Fotios, additional, Lipton, Jeffrey, additional, Mattsson, Jonas, additional, and Alibhai, Shabbir, additional

Published
2023
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7. Impact of hematopoietic cell transplant frailty scale on transplant outcome in adults

Author

Salas, Maria Queralt, primary, Atenafu, Eshetu G., additional, Pasic, Ivan, additional, Al-Shaibani, Eshrak, additional, Bascom, Ora, additional, Wilson, Leeann, additional, Chen, Carol, additional, Law, Arjun Datt, additional, Lam, Wilson, additional, Novitzky-Basso, Igor, additional, Kim, Dennis, additional, Gerbitz, Armin, additional, Viswabandya, Auro, additional, Michelis, Fotios V., additional, Lipton, Jeffrey Howard, additional, Mattsson, Jonas, additional, Alibhai, Shabbir, additional, and Kumar, Rajat, additional

Published
2022
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8. Impact of Cytomegalovirus (CMV) Sero-Conversion Pre Allogeneic Stem Cell Transplant on Post-Transplant Outcomes

Author

Sayyed, Ayman, primary, Wilson, Leeann, additional, Stavi, Vered, additional, Chen, Shiyi, additional, Mattsson, Jonas, additional, Lipton, Jeffrey H., additional, Kim, Dennis D.H., additional, Viswabandya, Auro, additional, Kumar, Rajat, additional, Lam, Wilson, additional, Law, Arjun D., additional, Gerbitz, Armin, additional, Pasic, Ivan, additional, Novitzky-Basso, Igor, additional, and Michelis, Fotios V., additional

Published
2022
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9. Frailty Scale for Outcome Predictions in Hematopoietic Cell Transplanted Adults

Author

Salas, María Queralt, primary, Atenafu, Eshetu G., additional, Al-Shaibani, Eshrak, additional, Bascom, Ora, additional, Wilson, Leeann, additional, Pasic, Ivan, additional, Law, Arjun Datt, additional, Lam, Wilson, additional, Kim, Dennis D, additional, Gerbitz, Armin, additional, Viswabandya, Auro, additional, Lipton, Jeffrey H, additional, Michelis, Fotios V, additional, Mattsson, Jonas, additional, Alibhai, Shabbir MH, additional, and Kumar, Rajat, additional

Published
2022
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10. Frailty Scale for Outcome Predictions in Hematopoietic Cell Transplanted Adults

Author

Salas, Maria Queralt, primary, Atenafu, Eshetu G, additional, Al-Shaibani, Eshrak, additional, Bascom, Ora, additional, Wilson, Leeann, additional, Chen, Carol, additional, Pasic, Ivan, additional, Law, Arjun, additional, Lam, Wilson, additional, Kim, Dennis Dong Hwan, additional, Gerbitz, Armin, additional, Viswabandya, Auro, additional, Lipton, Jeffrey H., additional, Michelis, Fotios, additional, Mattsson, Jonas, additional, Alibhai, Shabbir, additional, and Kumar, Rajat, additional

Published
2021
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11. Use of Pre-Transplant Minicog Cognitive Impairment Screening and Validation of Frailty and Functionality Assessment Prior to Allogeneic Hematopoietic Stem Cell Transplantation

Author

Alfaro, Tommy, Salas, Maria Queralt, Atenafu, Eshetu, Bascom, Ora, Wilson, Leeann, Chen, Carol, Law, Arjun D., Gerbitz, Armin, Viswabandya, Auro, Michelis, Fotios, Lipton, Jeffrey H., Lam, Wilson, Novitzky-Basso, Igor, Kim, Dennis (Dong Hwan) Dong Hwan, Mattsson, Jonas, Pasic, Ivan, and Kumar, Rajat

Published
2023
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12. Pilot prospective study of Frailty and Functionality in routine clinical assessment in allogeneic hematopoietic cell transplantation

Author

Salas, Maria Queralt, primary, Atenafu, Eshetu G., additional, Bascom, Ora, additional, Wilson, Leeann, additional, Lam, Wilson, additional, Law, Arjun Datt, additional, Pasic, Ivan, additional, Kim, Dennis, additional, Michelis, Fotios V., additional, Al-Shaibani, Zeyad, additional, Gerbitz, Armin, additional, Viswabandya, Auro, additional, Lipton, Jeffrey Howard, additional, Mattsson, Jonas, additional, Alibhai, Shabbir M. H., additional, and Kumar, Rajat, additional

Published
2020
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13. Study on Frailty and Functionality on Routine Clinical Assessment in Allogeneichematopoietic Cell Transplantation to Predict Outcomes

Author

Salas, Maria Queralt, primary, Atenafu, Eshetu G., additional, Bascom, Ora, additional, Wilson, Leeann, additional, Law, Arjun Datt, additional, Lam, Wilson, additional, Al-Shaibani, Zeyad, additional, Loach, David, additional, Michelis, Fotios V, additional, Kim, Dennis D, additional, Lipton, Jeffrey H, additional, Viswabandya, Auro, additional, Mattsson, Jonas, additional, Alibhai, Shabbir MH, additional, and Kumar, Rajat, additional

Published
2020
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16. Pilot Study on Frailty and Functionality on Routine Clinical Assessment in Allogeneichematopoietic Cell Transplantation to Predict Outcomes

Author

Salas, Maria Queralt, primary, Atenafu, Eshetu G, primary, Bascom, Ora, primary, Wilson, Leeann, primary, Law, Arjun, primary, Lam, Wilson, primary, Loach, David, primary, Al-Shaibani, Zeyad, primary, Michelis, Fotios V., primary, Kim, Dennis Dong Hwan, primary, Lipton, Jeffrey H., primary, Viswabandya, Auro, primary, Mattsson, Jonas, primary, Shabbir, Alibhai M.H., primary, and Kumar, Rajat, primary

Published
2019
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