Search

Tanner J Ferguson,1,2 Caroline W Wilson,3 Brian M Shafer,4 John P Berdahl,1,2 Daniel C Terveen1,2 1Vance Thompson Vision, Sioux Falls, SD, USA; 2University of South Dakota Sanford School of Medicine, Sioux Falls, SD, USA; 3Wolfe Eye Clinic, Cedar Rapids, IA, USA; 4Chester County Eye Care, Malvern, PA, USACorrespondence: Tanner J Ferguson, Vance Thompson Vision, 3101 W. 57th Street, Sioux Falls, SD, 57108, USA, Email tannerferg@gmail.comPurpose: To evaluate the clinical outcomes of a non-diffractive, wavefront-shaping extended depth-of-focus (EDOF) intraocular lens (IOL) in eyes with mild open-angle glaucoma (OAG).Setting: Private practice; Sioux Falls, South Dakota.Design: Prospective, open-label, interventional study.Methods: In total, 52 eyes of 26 patients with mild OAG were enrolled and completed the study. All patients were bilaterally implanted with a non-diffractive, wavefront-shaping EDOF IOL. Seventy-seven percent of the patients were implanted with a trabecular microbypass stent at the time of surgery. Primary outcome measures included binocular corrected and uncorrected distance visual acuity (CDVA and UDVA), uncorrected intermediate and near visual acuity (UIVA and UNVA) and contrast sensitivity as measured by a Pelli-Robson chart. A subjective questionnaire was also administered to patients.Results: At 4 months postoperative, the mean binocular UDVA and CDVA was 0.03 ± 0.12 and − 0.06 ± 0.07, respectively. The mean UIVA and UNVA were 0.18 ± 0.12 and 0.31 ± 0.18, respectively. Eighty-five percent of the subjects achieved ≥ 20/25 UDVA and 77% of the subjects achieved ≥ 20/32 UIVA at 4 months postoperative. The mean binocular mesopic contrast sensitivity was 1.76 ± 0.16 at a spatial frequency of 1 cycle-per-degree (cpd). Eighty-five percent of the subjects reported they would choose the same lens and 1 subject reported they would choose a different IOL if it meant reduced spectacle independence.Conclusion: The non-diffractive, wavefront-shaping EDOF IOL can be safely implanted in eyes with mild, pre-perimetric open-angle glaucoma with favorable uncorrected distance and intermediate visual acuity. The contrast sensitivity measurements were favorable and the subjective questionnaire revealed satisfactory spectacle independence and patient satisfaction.Keywords: EDOF IOL, extended depth-of-focus IOL, cataract surgery, refractive cataract surgery, cataract surgery in glaucoma

The spatiotemporal proteome of the intervertebral disc (IVD) underpins its integrity and function. We present DIPPER, a deep and comprehensive IVD proteomic resource comprising 94 genome-wide profiles from 17 individuals. To begin with, protein modules defining key directional trends spanning the lateral and anteroposterior axes were derived from high-resolution spatial proteomes of intact young cadaveric lumbar IVDs. They revealed novel region-specific profiles of regulatory activities and displayed potential paths of deconstruction in the level- and location-matched aged cadaveric discs. Machine learning methods predicted a ‘hydration matrisome’ that connects extracellular matrix with MRI intensity. Importantly, the static proteome used as point-references can be integrated with dynamic proteome (SILAC/degradome) and transcriptome data from multiple clinical samples, enhancing robustness and clinical relevance. The data, findings, and methodology, available on a web interface (http://www.sbms.hku.hk/dclab/DIPPER/), will be valuable references in the field of IVD biology and proteomic analytics.

Abstract Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathways. Here, we show SEMA3C drives activation of multiple RTKs including EGFR, ErbB2, and MET in a cognate ligand‐independent manner via Plexin B1. SEMA3C expression levels increase in castration‐resistant prostate cancer (CRPC), where it functions to promote cancer cell growth and resistance to androgen receptor pathway inhibition. SEMA3C inhibition delays CRPC and enzalutamide‐resistant progression. Plexin B1 sema domain‐containing:Fc fusion proteins suppress RTK signaling and cell growth and inhibit CRPC progression of LNCaP xenografts post‐castration in vivo. SEMA3C inhibition represents a novel therapeutic strategy for treatment of advanced prostate cancer.

Objectives: (1) Examine the feasibility of a community-based exercise intervention for persons with spinal cord injury and (2) compare the cardiorespiratory fitness, skeletal muscle strength, and psychosocial well-being of participants in the intervention group versus control group., Design: Community-based pilot randomized controlled trial. Setting : Accessible community-based health and wellness center. Participants : Thirty-two sedentary community-dwelling adults with any level of spinal cord injury. Interventions: Participants were randomized to a 36-session/12-week community-based exercise program (intervention; EG) or to a 36-session/12-week physical activity education group (control; CG). Outcome measures : Primary outcome measures included cardiorespiratory fitness measured by a VO 2 peak test, a composite score of four upper extremity musculoskeletal strength 1-repetition maximum exercises, and feasibility measured by EG participants' adherence and exercise intensity achieved during the program. EG participants' acceptance of the program was also evaluated using a self-reported satisfaction scale. Self-efficacy, motivation, pain, and goal performance and satisfaction were secondary outcome measures. Adherence and acceptability were also measured., Results: Fifteen participants ( n  = 15) completed the community-based exercise intervention and seventeen ( n  = 17) completed the education program. While no statistically significant differences were found, the EG experienced changes of moderate effect size in cardiorespiratory fitness, strength, motivation, and satisfaction with their goals. The EG attended, on average, two sessions per week. The community-based exercise intervention was highly accepted by and satisfying for participants to engage in., Conclusions: The EG had improvements in the two primary measures, cardiorespiratory fitness and musculoskeletal strength, following the intervention. The community-based exercise intervention was feasible and accepted by participants.

Background: Racism in nursing is a significant issue affecting patient safety, nurse well-being, and job performance., Purpose: Explore racial microaggression experiences of registered nurses working in a children's hospital., Methods: An exploratory, qualitative research design with in-depth interviews was used to collect data., Discussion: Three categories containing 12 themes resulted. Nurses experienced (1) Biased first impressions, (2) "Firing" the nurse, (3) Questioning experience or credentials, (4) Where do I belong? and (5) All jokes have a grain of truth. Nurses responded through (6) Not being silent, (7) Intentional nonconfrontation, and (8) Showing or seeking support. Nurses used strategies of (9) Empowering, (10) Bracketing, (11) Communicating thoughtfully to build trust, and (12) Doing more to be perceived the same., Conclusion: Most nurses in the study experienced and committed racial microaggressions; therefore, must be equipped with tools to recognize and respond to them. Moreover, microaggressions negatively impact building a diverse nursing workforce., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Neurodegeneration in glaucoma patients is clinically identified through longitudinal assessment of structure-function changes, including intraocular pressure, cup-to-disc ratios from fundus images, and optical coherence tomography imaging of the retinal nerve fiber layer. Use of human post-mortem ocular tissue for basic research is rising in the glaucoma field, yet there are challenges in assessing disease stage and severity, since tissue donations with informed consent are often unaccompanied by detailed pre-mortem clinical information. Further, the interpretation of disease severity based solely on anatomical and morphological assessments by histology can be affected by differences in death-to-preservation time and tissue processing. These are difficult confounders that cannot be easily controlled. As pathogenesis and molecular mechanisms can vary depending on the stage and severity of glaucoma, there is a need for the field to maximize use of donated tissue to better understand the molecular mechanisms of glaucoma and develop new therapeutic hypotheses. Further, there is a lack of consensus around the molecular RNA and protein markers that can be used to classify glaucoma severity. Here, we describe a multiparametric grading system that combines structural measurements of the retinal nerve fiber layer with linear regression and principal component analyses of molecular markers of retinal ganglion cells and glia (RBPMS, NEFL, IBA1 and GFAP) to stratify post-mortem glaucoma eyes by the severity of disease. Our findings show that a quantitative grading approach can stratify post-mortem glaucoma samples with minimal clinical histories into at least three severity groups and suggest that this type of approach may be useful for researchers aiming to maximize insights derived from eye bank donor tissue., Competing Interests: Declarations. Ethics approval and consent to participate: Deidentified post-mortem human eyes were procured by the Lions Eye Institute for Transplant & Research (LEITR; Tampa FL) with consent of donors or donors’ next of kin and in accordance with the Eye Bank Association of America (EBAA) medical standards, applicable US/Florida law for human tissue donation, the Declaration of Helsinki and FDA regulations, and Novartis guidelines regarding human tissue research. Consent for publication: All human samples used in this manuscript were deidentified and are unattributable to specific individuals, so specific individual consent is not applicable. Competing interests: CX, VR, YQ, MM, JTD, CLG, CWW and GP are all employees of Novartis and may hold stock., (© 2024. Novartis BioMedical Research.)

Sea ice is a critical component of the cryosphere and plays a role in the heat and moisture exchange processes between the ocean and atmosphere, thus regulating the global climate. With climate change, detailed monitoring of changes occurring in sea ice is necessary. Therefore, an analysis was conducted to evaluate the potential of using the Gray Level Co-occurrence Matrix (GLCM) texture analysis combined with the backscattering coefficient (σ°) of HH polarization in Sentinel-1A Synthetic Aperture Radar (SAR) images, interferometric imaging mode, for mapping sea ice in time series. Data processing was performed using cloud computing on the Google Earth Engine platform with routines written in JavaScript. To train the Random Forest (RF) classifier, samples of regions with open water and sea ice were obtained through visual interpretation of false-color SAR images from Sentinel-1B in the extra-wide swath imaging mode. The analysis demonstrated that training samples used in the RF classifier from a specific date can be applied to images from other dates within the freezing period, achieving accuracies ≥ 90% when using 64-bit grayscale quantization in GLCM combined with σ° data. However, when using only σ° data in the RF classifier, accuracies ≥ 93% were observed.

Background: demand for public prepared food with numerous food handlers creates uncertainties in the quality of safe foods and possible food contamination. This study aimed to ascertain the food safety hygiene practices, and associated factors among public food handlers in Enugu Metropolis, Nigeria., Methodology: This was a cross-sectional study conducted among 400 public food handlers in Enugu Metropolis, Nigeria. Samples were selected using a multistage sampling technique. Data was collected using pretested structured interviewer administered questionnaire and analyzed using percentage, mean and multiple regression. Statistical significance was set at p< 0.05., Results: The mean age of respondents were 31.16 ± 8.242 years. About two - thirds, 66.5% of respondents were found to have good knowledge of food hygiene safety practices. The overall food safety hygiene practice mean score was 80.10 ± 10.25 with 70.5% showing good practice. Environmental safety hygiene had good practice of 35.0% and mean score of 24.17 ± 2.29. The factors which statistically significantly predicted overall food safety practices, F (11, 388) = 42.957, P < 0.0001, R 2 = 0.536 were educational level (β = 0.148, C.I = 0.860 - 3.082), knowledge level (β = 8.594, C.I = 5.635 - 8.979) and safety trainings (β = 0.517, C.I = 4.102 - 5.474)., Conclusion: There were good safety hygiene practices except on environmental safety hygiene practices component. Safety training, knowledge level and educational level were the predictors of good practices. Frequent training is most needed to prevent or control food contamination and consequent food borne diseases., Competing Interests: The authors declare that they have no conflicts of Interest., (Copyright © 2024 Nigerian Medical Association.)

Significance: Historically, tobacco product emissions testing using smoking machines has largely focused on combustible products, such as cigarettes and cigars. However, the popularity of newer products, such as electronic cigarettes (e-cigarettes), has complicated emissions testing because the products' mouth-end geometries do not readily seal with existing smoking and vaping machines. The demand for emissions data on popularly used products has led to inefficient and non-standardised solutions, such as laboratories making their geometry-specific custom adaptors and/or employing flexible tubing, for each unique mouth-end geometry tested. A user-friendly, validated, universal smoking machine adaptor (USMA) is needed for testing the variety of tobacco products reflecting consumer use, including e-cigarettes, heated tobacco products, cigarettes, plastic-tipped cigarillos and cigars., Methods: A prototype USMA that is compatible with existing smoking/vaping machines was designed and fabricated. The quality of the seal between the USMA and different tobacco products, including e-cigarettes, cigars and cigarillos, was evaluated by examining the leak rate., Results: Unlike commercial, product-specific adaptors, the USMA seals well with a wide range of tobacco product mouth-end geometries and masses. This includes e-cigarettes with non-cylindrical mouth ends and cigarillos with cuboid-like plastic tips. USMA leak rates were lower than or equivalent to commercial, product-specific adaptors., Conclusion: This report provides initial evidence that the USMA seals reliably with a variety of tobacco product mouth-end geometries and can be used with existing linear smoking/vaping machines to potentially improve the precision, repeatability and reproducibility of machine smoke yield data. Accurate and reproducible emissions testing is critical for regulating tobacco products., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)

This work investigated the annual variations in dry snow (DSRZ) and wet snow radar zones (WSRZ) in the north of the Antarctic Peninsula between 2015-2023. A specific code for snow zone detection on Sentinel-1 images was created on Google Earth Engine by combining the CryoSat-2 digital elevation model and air temperature data from ERA5. Regions with backscatter coefficients (σ⁰) values exceeding -6.5 dB were considered the extent of surface melt occurrence, and the dry snow line was considered to coincide with the -11 °C isotherm of the average annual air temperature. The annual variation in WSRZ exhibited moderate correlations with annual average air temperature, total precipitation, and the sum of annual degree-days. However, statistical tests indicated low determination coefficients and no significant trend values in DSRZ behavior with atmospheric variables. The results of reducing DSRZ area for 2019/2020 and 2020/2021 compared to 2018/2018 indicated the upward in dry zone line in this AP region. The methodology demonstrated its efficacy for both quantitative and qualitative analyses of data obtained in digital processing environments, allowing for the large-scale spatial and temporal variations monitoring and for the understanding changes in glacier mass loss.

Significance: Characterisation of tobacco product emissions is an important step in assessing their impact on public health. Accurate and repeatable emissions data require that a leak-tight seal be made between the smoking or vaping machine and the mouth-end of the tobacco product being tested. This requirement is challenging because of the variety of tobacco product mouth-end geometries being puffed on by consumers today. We developed and tested a prototype universal smoking machine adaptor (USMA) that interfaces with existing machines and reliably seals with a variety of tobacco product masses and geometries., Methods: Emissions were machine-generated using the USMA and other available adaptors for a variety of electronic cigarettes (n=7 brands), cigars (n=4), cigarillos (n=2), a heated tobacco product, and a reference cigarette (1R6F), and mainstream total particulate matter (TPM) and nicotine were quantified. Data variability (precision, n≥10 replicates/brand) for all products and error (accuracy) from certified values (1R6F) were compared across adaptors., Results: TPM and nicotine emissions generated using the USMA were accurate, precise and agreed with certified values for the 1R6F reference cigarette. Replicate data indicate that USMA repeatability across all tobacco products tested generally meets or exceeds that from the comparison adaptors and extant data., Conclusion: The USMA seals well with a variety of combustible tobacco products, e-cigarettes with differing geometries and plastic-tipped cigarillos. Variability for all measures was similar or smaller for the USMA compared with other adaptors., Competing Interests: Competing interests: No, there are no competing interests., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)

Background: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders among children. Pharmacotherapy has been the primary treatment for ADHD, supplemented by behavioral interventions. Digital and exercise interventions are promising nonpharmacologic approaches for enhancing the physical and psychological health of children with ADHD. However, the combined impact of digital and exercise therapies remains unclear., Objective: The aim of this study was to determine whether BrainFit, a novel digital intervention combining gamified cognitive and exercise training, is efficacious in reducing ADHD symptoms and executive function (EF) among school-aged children with ADHD., Methods: This 4-week prospective randomized controlled trial included 90 children (6-12 years old) who visited the ADHD outpatient clinic and met the diagnostic criteria for ADHD. The participants were randomized (1:1) to the BrainFit intervention (n=44) or a waitlist control (n=46) between March and August 2022. The intervention consisted of 12 30-minute sessions delivered on an iPad over 4 weeks with 3 sessions per week (Monday, Wednesday, and Friday after school) under the supervision of trained staff. The primary outcomes were parent-rated symptoms of attention and hyperactivity assessed according to the Swanson, Nolan, and Pelham questionnaire (SNAP-IV) rating scale and EF skills assessed by the Behavior Rating Inventory of Executive Function (BRIEF) scale, evaluated pre and post intervention. Intention-to-treat analysis was performed on 80 children after attrition. A nonparametric resampling-based permutation test was used for hypothesis testing of intervention effects., Results: Among the 145 children who met the inclusion criteria, 90 consented and were randomized; ultimately, 80 (88.9%) children completed the study and were included in the analysis. The participants' average age was 8.4 (SD 1.3) years, including 63 (78.8%) male participants. The most common ADHD subtype was hyperactive/impulsive (54/80, 68%) and 23 (29%) children had severe symptoms. At the endpoint of the study, the BrainFit intervention group had a significantly larger improvement in total ADHD symptoms (SNAP-IV total score) as compared to those in the control group (β=-12.203, 95% CI -17.882 to -6.523; P<.001), owing to lower scores on the subscales Inattention (β=-3.966, 95% CI -6.285 to -1.647; P<.001), Hyperactivity/Impulsivity (β=-5.735, 95% CI -8.334 to -3.137; P<.001), and Oppositional Defiant Disorder (β=-2.995, 95% CI -4.857 to -1.132; P=.002). The intervention was associated with significant reduction in the Metacognition Index (β=-6.312, 95% CI -10.973 to -1.650; P=.006) and Global Executive Composite (β=-5.952, 95% CI -10.214 to -1.690; P=.003) on the BRIEF. No severe intervention-related adverse events were reported., Conclusions: This novel digital cognitive-physical intervention was efficacious in school-age children with ADHD. A larger multicenter effectiveness trial with longer follow-up is warranted to confirm these findings and to assess the durability of treatment effects., Trial Registration: Chinese Clinical Trial Register ChiCTR2300070521; https://www.chictr.org.cn/showproj.html?proj=177806., (©Licong Zhao, Heather Agazzi, Yasong Du, Hongdao Meng, Renya Maku, Ke Li, Peter Aspinall, Cynthia Wilson Garvan, Shuanfeng Fang. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 10.05.2024.)

Precise regulation of Type I interferon signaling is crucial for combating infection and cancer while avoiding autoimmunity. Type I interferon signaling is negatively regulated by USP18. USP18 cleaves ISG15, an interferon-induced ubiquitin-like modification, via its canonical catalytic function, and inhibits Type I interferon receptor activity through its scaffold role. USP18 loss-of-function dramatically impacts immune regulation, pathogen susceptibility, and tumor growth. However, prior studies have reached conflicting conclusions regarding the relative importance of catalytic versus scaffold function. Here, we develop biochemical and cellular methods to systematically define the physiological role of USP18. By comparing a patient-derived mutation impairing scaffold function (I60N) to a mutation disrupting catalytic activity (C64S), we demonstrate that scaffold function is critical for cancer cell vulnerability to Type I interferon. Surprisingly, we discovered that human USP18 exhibits minimal catalytic activity, in stark contrast to mouse USP18. These findings resolve human USP18's mechanism-of-action and enable USP18-targeted therapeutics., Competing Interests: VJ, HW, CWL, DRH, KL, ECR, MY, ZKJ, EC, YX, JS, BY, AG, PL, ACG, VF, PDW, and FW are current or former employees of Pfizer and may own Pfizer stock. BMK and APF receive research funding from Pfizer. This work was supported by Pfizer, and APF and BMK are funded by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS), China (grant nr - 2018-I2M-2-002)., (© 2024 Pfizer Inc.)

The metalloids boron and arsenic are ubiquitous and difficult to remove during water treatment. As chemical pretreatment using strong base and oxidants can increase their rejection during membrane-based nanofiltration (NF), we examined a nature-based pretreatment approach using benthic photosynthetic processes inherent in a unique type of constructed wetland to assess whether analogous gains can be achieved without the need for exogenous chemical dosing. During peak photosynthesis, the pH of the overlying clear water column above a photosynthetic microbial mat (biomat) that naturally colonizes shallow, open water constructed wetlands climbs from circumneutral to approximately 10. This biological increase in pH was reproduced in a laboratory bioreactor and resulted in analogous increases in NF rejection of boron and arsenic that is comparable to chemical dosing. Rejection across the studied pH range was captured using a monoprotic speciation model. In addition to this mechanism, the biomat accelerated the oxidation of introduced arsenite through a combination of abiotic and biotic reactions. This resulted in increases in introduced arsenite rejection that eclipsed those achieved solely by pH. Capital, operation, and maintenance costs were used to benchmark the integration of this constructed wetland against chemical dosing for water pretreatment, manifesting long-term (sub-decadal) economic benefits for the wetland-based strategy in addition to social and environmental benefits. These results suggest that the integration of nature-based pretreatment approaches can increase the sustainability of membrane-based and potentially other engineered treatment approaches for challenging water contaminants., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Ltd.)

Background and Aims: The limited alternatives to blood lead biomarkers continue to affect the control of occupational lead exposures. This study assessed the relationship and accuracy of urine lead biomarker as an alternative to blood lead biomarker among roadside and organized panel beaters in Enugu metropolis, Nigeria., Methods: This was a cross-sectional analytical study of 428 panel beaters in Enugu metropolis. Samples collected were analyzed using Atomic Absorption Spectrometer (AAS) at 283.3 nm wavelengths. Data were analyzed using correlation and receiver operating characteristics (ROC)., Result: A linear positive relationship with high accuracy and sensitivity were found between blood and urine biomarkers., Conclusion: Urine biomarker has a linear relationship with blood biomarker and showed a significant accuracy for the measurement of occupational lead exposure. Therefore, a urinary biomarker can serve as an alternative replacement to blood lead in occupational health practice., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Indian Journal of Occupational and Environmental Medicine.)

Effective post-operative pain management requires an accurate and frequent assessment of the pain experienced by the patients. The current gold-standard of pain assessment is through patient self-evaluation (e.g., numeric rating scale, NRS) which is subjective, prone to recall-bias, and does not provide comprehensive information of the pain intensity and its trends. We conducted a study to explore the potential of wearable biosensors and machine learning-based analysis of physiological parameters to estimate the pain intensity. The results from our study of post-operative knee surgery patients monitored over a period of 30 days demonstrate the feasibility of the system in ambulatory setting, with a substantial agreement (Cohen's Kappa = 0.70, 95% CI 0.68-0.72) between the pain intensity estimation and the patient reported numerical rating scale. Therefore, the wearable biosensors coupled with the machine learning-derived pain estimation are capable of remotely assessing the pain intensity.

In light of the perioperative nursing shortage, academic leaders at a mid-Atlantic school of nursing and leaders of three health care systems implemented an academic-practice partnership with the goal of increasing interest in this specialty. Nursing researchers used a descriptive study design to collect data from nursing alumni who participated in the perioperative elective between 2017 and 2021. They found that 25 (38%) of 65 graduates who participated in the elective entered perioperative nursing and 38 (68%) of 56 graduates who answered a question on considering future employment as a perioperative nurse indicated they would do so regardless of their current employment status. Graduates who participated in the elective and experienced a perioperative capstone placement had low anticipated turnover scores and intended to remain in a perioperative position. Academic and health care leaders should consider academic-practice partnerships as a strategy to recruit and retain perioperative nurses., (© AORN, Inc, 2023.)

Despite the fact that COVID-19 is no longer a global pandemic due to development and integration of different technologies for the diagnosis and treatment of the disease, technological advancement in the field of molecular biology, electronics, computer science, artificial intelligence, Internet of Things, nanotechnology, etc. has led to the development of molecular approaches and computer aided diagnosis for the detection of COVID-19. This study provides a holistic approach on COVID-19 detection based on (1) molecular diagnosis which includes RT-PCR, antigen-antibody, and CRISPR-based biosensors and (2) computer aided detection based on AI-driven models which include deep learning and transfer learning approach. The review also provide comparison between these two emerging technologies and open research issues for the development of smart-IoMT-enabled platforms for the detection of COVID-19.

Abstract: The study examined differences between military students enrolled in an accelerated bachelor of science in nursing (BSN) program with and without medical experience and/or a previous bachelor's degree on graduation grade point average (GPA) and NCLEX®-RN first-time pass rates. Significant differences were found between groups with/without military medical experience on NCLEX-RN, but not graduation GPA. Significant differences were found between groups with/without prior degree on GPA, but not on NCLEX-RN. Having both medical experience and a prior degree did not make a difference on GPA or NCLEX-RN. Findings offer guidance on admission criteria to accelerated programs for this unique group of students., Competing Interests: The authors have declared no conflict of interest., (Copyright © 2022 National League for Nursing.)

Abstract: This article describes a funded grant project whereby 10 tips are shared for those considering starting a veterans' bachelor of science in nursing initiative: secure the support of the institution; establish a point person for the initiative; maximize student success resources; acknowledge past academic work and military experience; hire prior-service Armed Forces Nurse Corps officers as faculty; deliver training opportunities for nonmilitary faculty to learn about veterans; offer students the opportunity to learn and socialize with their noncivilian peers; capitalize on the assets veterans bring to the classroom; provide a structured learning environment; and generate data-based publications., Competing Interests: The authors have declared no conflict of interest., (Copyright © 2021 National League for Nursing.)

Aims: This study uses prospective registry data to compare early patient outcomes following arthroscopic repair or debridement of the acetabular labrum., Methods: Data on adult patients who underwent arthroscopic labral debridement or repair between 1 January 2012 and 31 July 2019 were extracted from the UK Non-Arthroplasty Hip Registry. Patients who underwent microfracture, osteophyte excision, or a concurrent extra-articular procedure were excluded. The EuroQol five-dimension (EQ-5D) and International Hip Outcome Tool 12 (iHOT-12) questionnaires were collected preoperatively and at six and 12 months post-operatively. Due to concerns over differential questionnaire non-response between the two groups, a combination of random sampling, propensity score matching, and pooled multivariable linear regression models were employed to compare iHOT-12 improvement., Results: A total of 2,025 labral debridements (55%) and 1,659 labral repairs (45%) were identified. Both groups saw significant (p < 0.001) EQ-5D and iHOT-12 gain compared to preoperative scores at 12 months (iHOT-12 improvement: labral repair = +28.7 (95% confidence interval (CI) 26.4 to 30.9), labral debridement = +24.7 (95% CI 22.5 to 27.0)), however there was no significant difference between procedures after multivariable modelling. Overall, 66% of cases achieved the minimum clinically important difference (MCID) and 48% achieved substantial clinical benefit at 12 months., Conclusion: Both labral procedures were successful in significantly improving early functional outcome following hip arthroscopy, regardless of age or sex. Labral repair was associated with superior outcomes in univariable analysis, however there was no significant superiority demonstrated in the multivariable model. Level of evidence: III Cite this article: Bone Jt Open  2022;3(4):291-301.

Purpose: The purpose of this study was to add experiential data from individuals with lived experiences of eating disorder recovery to the existing literature, regarding daily habits and attitudes toward eating and self-weighing., Methods: An anonymous open-ended online survey was completed by 32 adults. One was excluded due to current eating disordered behaviors. Remaining participants were divided into three self-identified groups: Recovered from an eating disorder, Recovering from an eating disorder, and Partially Recovered from an eating disorder., Results: Results showed the Recovered group reported more years of recovery than the other two groups, named "recovered" as part of their identity, practiced intuitive or regular eating instead of a prescribed meal plan, and held negative attitudes about self-weighing. The Recovering group reported, "I will always be recovering," and either followed prescribed meal plans or weighed themselves and did not expect to change those behaviors. The Partially Recovered group did not see themselves as recovered, but aspired to become recovered, and if they followed a prescribed meal plan or self-weighed, then they expected to change these behaviors in the future., Conclusions: There is a difference in years of recovery, meal planning, and scale attitudes, among people who self-identify in the recovery categories of Recovered, Recovering, and Partially Recovered. These results can (1) help providers better serve clients with eating disorders; (2) help researchers better understand individuals who have suffered from eating disorders and are in the recovery process; and (3) offer guidance and hope for those in recovery., Level of Evidence: Level IV, Evidence obtained from multiple time series analysis such as case studies. (NB: Dramatic results in uncontrolled trials might also be regarded as this type of evidence)., (© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Objective: The purpose of this study was to determine how support and guidance provided by trained professionals during a 12-week, community-based transition exercise program, impact health outcomes and continued engagement in physical activity for persons with a mobility disability (PwMD)., Design: A single arm pre-post design was used., Setting: Accessible community-based health and wellness center., Participants: The study included 244 PwMD using a mobility device., Interventions: Participants completed a 12-week transition exercise program provided through an accessible community facility that provided education and support to complete endurance and strength related exercises as well as programming to encourage transition to self-directed engagement in exercise., Main Outcome Measures: Bodyweight, BMI, pain, perceived exertion, speed, and distance during cardiovascular fitness testing, and strength were measured pre and post exercise program. The number of participants that signed up for a monthly membership after the program was also monitored., Results: For the total group, average pain reported over previous 30 days decreased significantly ( p < 0.01), current daily pain decreased significantly ( p < 0.05), perceived exertion at the end of the 9-min endurance test decreased significantly ( p < 0.05), and the four upper extremity strength exercises showed large, significant strength gains ( p < 0.01) after the program. There was no significant change in bodyweight, BMI, or speed and distance completed during endurance testing. At the completion of the program, 76% of participants enrolled in a monthly membership at the facility with the intentions to continue to exercise regularly., Conclusions: This study provides evidence that an accessible community-based exercise program, with a transitional component supported by trained professionals, can support the exercise goals of PwMD and improve strength, decrease pain, and may promote regular exercise adoption for PwMD., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Morgan, Taylor, Walker, Tucker, Dashner and Hollingsworth.)