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The article provides an answer to a question regarding the good quality insulin-sensitizing medication for polycystic ovary syndrome (PCOS) in patient who cannot tolerate merformin drug.

The article provides information on epiduo which is a combination of 0.1 percent topical adapalene and 2.5 percent benzoyl peroxide for the treatment of acne vulgaris for patients not less than 12 years old. The mechanisms of adapalene are discussed, including reducing inflammation, cellular differentiation and microcomedone development. Some studies showed that adapalene increases the risk of photosensivity. Also discussed is the tolerability and effectiveness of combining adapalene and benzoyl peroxide.

A simulation-based training curricula applied to the primary care evaluation and management of shoulder and knee pain resulted in improved access to care for veterans and cost savings for the health care system., Competing Interests: Author disclosures The authors report no actual or potential conflicts of interest with regard to this article., (Copyright © 2020 Frontline Medical Communications Inc., Parsippany, NJ, USA.)

The best approach for screening patients hinges on the number, degree, and age of relatives diagnosed with colorectal cancer (CRC) or adenomatous polyps (AP). Screening should begin at 40 years of age for patients with a family history of CRC or AP in at least 1 first-degree relative or CRC in at least 2 second-degree relatives. Patients at highest risk-who have 1 first-degree relative diagnosed with CRC or AP before 60 years of age or multiple first-degree relatives diagnosed at any age-should begin screening with colonoscopy at 40 years of age or 10 years younger than the earliest affected relative and undergo a repeat colonoscopy every 5 years. Patients who have a first-degree relative diagnosed with CRC or AP after 60 years of age or 2 or more second-degree relatives with CRC should start screening at 40 years of age, with routine options and follow-up intervals. (Routine options and follow-up intervals include any of the following 3 regimens: annual high-sensitivity fecal occult blood testing, sigmoidoscopy every 5 years combined with high-sensitivity fecal occult blood testing every 3 years, or screening colonoscopy every 10 years.).