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4. Epidemiology, genetics and management of psoriatic arthritis 2013: focus on developments of who develops the disease, its clinical features, and emerging treatment options

Author

Haroon M, FitzGerald O, and Winchester R

Subjects
Dermatology, RL1-803
Abstract

Muhammad Haroon,1 Oliver FitzGerald,1 Robert Winchester2 1Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland; 2Division of Rheumatology, Columbia University College of Physicians and Surgeons, New York, NY, USA Abstract: The picture of elements comprising the genetic susceptibility to develop psoriatic arthritis, especially those involving human leukocyte antigen alleles, is emerging in much greater clarity because of improvements in the methods of psoriatic arthritis ascertainment and in the technology of genetic typing. This new knowledge suggests there is genetic heterogeneity in the psoriasis phenotype, and that there are several genetically and clinically different forms of psoriatic arthritis. These genetic studies on psoriatic arthritis further reinforce the relationship of psoriatic arthritis to the other spondyloarthritides, but also raise novel questions of whether the effect of certain susceptibility genes may differ among them. Considerable evidence indicates that the clinical features reflect a CD8 T lymphocyte-driven immune response is present that is characterized by clonal expansion and differentiation towards memory-effector phenotypes. With the aid of new classification criteria, the typical clinical features of psoriatic arthritis involving different joints, entheses, and their related compartments are being better defined as distinctive characteristics of psoriatic arthritis or of the spondyloarthritis group of disorders. In the evaluation of an individual with psoriatic arthritis, taking a patient-focused perspective is recommended, which has the potential to enhance their quality of life significantly. The choice of current and emerging therapeutic agents from an increasing realm of conventional and biologic agents is becoming much better rationalized and more firmly based on evidence from clinical trials. Keywords: psoriatic arthritis, genetic susceptibility, heterogeneity, classification, diagnostic criteria, treatment

Published
2013

10. Southern California Iris Gardens, formerly Dean Iris Gardens : nineteen hundred and twenty-eight [price list] /

Author

Southern California Iris Gardens, Milliken, C. S., Winchester, R. E., Dean Iris Gardens, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, U.S. Department of Agriculture, National Agricultural Library, Southern California Iris Gardens, Milliken, C. S., Winchester, R. E., Dean Iris Gardens, and Henry G. Gilbert Nursery and Seed Trade Catalog Collection

Subjects
Bulbs (Plants), California, Irises (Plants), Nursery stock, Pasadena, Prices, Varieties
Published
1928

12. Regulatory [CD8.sup.+] T cells fine-tune the myelin basic protein-reactive T cell receptor V[beta] repertoire during experimental autoimmune encephalomyelitis

Author

Jiang, H., Curran, S., Ruiz-Vazquez, E., Liang, B., Winchester, R., and Chess, L.

Subjects
Cytokines -- Physiological aspects, T cells -- Physiological aspects, Science and technology
Abstract

A significant number of self-reactive T cell clones escape thymic negative selection and are released into the periphery, where some are potentially pathogenic. The clonal expansion of self-reactive T cells is known to be limited during initial antigen encounter by apoptotic or anergic mechanisms, regulatory [CD4.sup.+] T cells, and cytokines. Here we report that superimposed on these mechanisms, during the evolution of autoimmunity in experimental autoimmune encephalomyelitis (EAE), [CD8.sup.+] T cells are induced, which fine-tune the peripheral self-reactive T cell receptor (TCR) repertoire. We assayed the myelin basic protein-reactive TCR repertoire in naive, EAE-recovered mice as well as EAE-recovered mice depleted of [CD8.sup.+] T cells by TCRV[beta] surface expression, complementarity-determining region 3 length distribution, and complementarity-determining region 3 sequencing analysis. In EAE-recovered mice, certain myelin basic protein-reactive [CD4.sup.+][beta][8.2.sup.+] clones are significantly decreased and this decrease is not observed if [CD8.sup.+] T cells were depleted from these mice. The clones that persist in [CD8.sup.+] T cell-intact mice are highly diverse in contrast to the clones expanded in [CD8.sup.+] T cell-depleted mice, which are dominated by the significant outgrowth of a few clones. Importantly, the T cell clones that expand in the absence of [CD8.sup.+] T cell control are enriched in potentially pathogenic self-reactive T cell clones capable of inducing EAE in vivo.

Published
2003

19. Consensus statement

Author

Edwards, J. C. W., Winchester, R., Henderson, B., Laurent, T., Schumacher, H. R., Simkin, P., Wooley, D., Lindblad, S., Bresnihan, B., and Levick, J. R.

Published
1995

22. Expression and Characterization of Leucocyte Antigens

Author

Allen, R., Ferrone, S., Hoch, J., Bankhurst, A., Spellmann, J., Burmester, G. R., Dimitriu-Bona, A., Gregersen, P., Waters, S. J., Winchester, R. J., Burrone, O. R., Calabi, F., Gilmore, D., Wright, B., Milstein, C., Clark, E., Martin, P., Hansen, J., Ledbetter, J., de Leij, L., Poppema, S., The, T. H., De Vries, J. E., Vaessen, R., Janssens, P., Tan, B., Heiman, A., Figdor, C. G., Dörken, B., Pfreundschuh, M., Moldenhauer, G., Schwarz, E., Hämmerling, G., Frisman, D., Baird, S., Gazit, E., Gothelf, Y., Gil, R., Orgad, S., Yunis, E. J., Girardet, Ch., Heumann, D., Mach, J.-P., von Fliedner, V., Carrel, S., Goyert, S. M., Silver, J., Hogg, N., Hokland, P., Schlossman, S. F., Ritz, J., Kalil, J., Abita, J. P., Chomienne, C., Poirier, O., Besluau, D., Dastot, H., Reboul, M., Fellous, M., Colombani, J., Kater, L., Brekelmans, P., Daemen, T., Schuurman, H. J., Katz, F., Povey, S., Stanley, K., Schneider, C., Greaves, M., Lemonnier, F. A., Le Bouteiller, P. P., Malissen, B., Golstein, P., Malissen, M., Mishal, Z., Caillol, D. H., Jordan, B. R., Kourilsky, F., Lennert, K., Stein, H., Miiller-Hermelink, H. K., Vollenweider, R., Karol, R. A., Eng, J., Dennison, D., Faris, E., Marcus, D. M., Piatier-Tonneau, D., Boyer, B., Debre, P., Charron, D., Reuben, J. M., Hersh, E. M., Mansell, P. W. A., Newell, G., Rios, A., Rumpold, H., Kraft, D., Förster, O., Schulz, T. F., Alsenz, J., Scheiner, O., Lambris, J., Dierich, M. P., Van Laarhoven, J. P. R. M., Broekhuizen, R., Spierenburg, G. Th., De Bruyn, C. H. M. M., Solbach, W., Röllinghoff, M., Wagner, H., Szer, I. S., Irani, A., Tax, W. J. M., Janossy, G., Jonker, M., Willems, R., Leeuwenberg, J., Capel, P. J. A., Koene, R. A. P., Leeuwenberg, H. F. M., Willems, H. M., Tetteroo, P. A. T., Visser, F., Landsdorp, P., von dem Borne, A. E. G. Kr., Thompson, J. S., Goeken, N. E., Brown, S. A., Rhoades, J. R., Yamamoto, K., Nakauchi, H., Karasuyama, H., Kitamura, K., Tanimoto, K., Okumura, K., Bernard, Alain, editor, Boumsell, Laurence, editor, Dausset, Jean, editor, Milstein, César, editor, and Schlossman, Stuart F., editor

Published
1984
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26. Antigen Society #21 Report DR1, DRw10)

Author

Lamm, L. U., Brautbar, C., Fauchet, R., Lee, T., Jalais, E., Zhao, T., Battat, S., Hunter, J., Dunston, G., Garrido, F., Winchester, R. J., Mervart, H., Nunez-Roldan, A., and Dupont, Bo, editor

Published
1989
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29. Third Eular Workshop on Rheumatology Research: Mainz February 1983

Author

Gleichmann, E., van Rappard-van der Veen, F. M., Rolink, A. G., Pals, S. T., Trautwein, G., Hewicker, M., Waterfield, J. D., Maini, R. N., Botzenhardt, U., Müller, J., Lemmel, E. -M., Bartlett, R., Steldern, D. v., Field, M., Schrieber, L., Melsom, R. D., Venables, P. J., McCarthy, D. A., de Vries, B. J., van den Berg, W. B., van de Putte, L. B. A., van den Berg, W. B., Lens, J. W., Kruijsen, M. W. M., Brackertz, D., Mohr, W., Fritsch, R., Holmdahl, R., Rubin, K., Klareskog, L., Radaszkiewicz, T., Dreher, R., Köhler, G., Rieber, P., Weber, U., Kirchhoff, H., Heitmann, J., Hermanns, W., Schulz, L. Cl., Marquardt, J., Rojem, P., Schulz, L. C., Brighton, S. W., Vermeulen, W. A., Madhok, R., Sturrock, R. D., Forbes, C., Bennett, D., Leibold, W., Hangoc, G., Böhm, K. H., Rimpler, M., Grabczewska, E., Maslinski, W., Krzystyniak, K., Ryzewski, J., Mbuyi, J. M., Dequeker, J., Junker, P., Oxlund, H., Lorenzen, G. H., Lorenzen, I., Van Paassen, H. C., De Vries, E., Mallee, C., Bijvoet, O. L. M., Cats, A., Ball, J., Wessinghage, D., Kirkpatrick, C. J., Verbruggen, G., Luyten, F., Veys, E. M., Annefeld, M., Velvart, M., Fehr, K., Seidel, J., Menninger, H., Gurr, E., Stangel, W., Deicher, H., Fobbe, C., Starck, P., Kleesiek, K., Greiling, H., Biemond, P., Swaak, A. J. G., Koster, J. F., Hall, N. D., Maslen, C., McKeown, M. J., Parnham, M. J., Bittner, C., Hurst, N. P., Bessac, B., Nuki, G., Neumüller, J., Dunky, A., Senautka, G., Eberl, R., Lemmel, E. M., Lindgren, J. A., Appelboom, T., Gortz, R., Madia, W., Loos, M., Heinz, H. P., Mortazavi-Milani, S. M., Holborow, E. J., Lindblad, S., Hedfors, E., Meijer, C. J. L. M., Lafeber, G. J. M., Vulpen-Cnossen, J., Damsteeg, W. G. M., Warnatz, H., Lemm, G., van der Weij, J. P., van der Veen, C. J. P., Burmester, G. R., Menche, D., Merryman, P., Dimitriu-Bona, A., Klein, M., Winchester, R., Corke, C. F., Gul, V., Stierle, H., Huskisson, E. C., Holborrow, E. J., Froebel, K., Dickson, R., Lewis, D., Kávai, M., Sonkoly, I., Csongor, J., Szegedi, Gy., Schmidt, R. E., Mollenhauer, E., Heinrichs, M., Rittner, C., Schneider, E. M., Pawelec, G., Müller, C., Blaurock, M., Shaw, S., Wernet, P., Winrow, V. R., Stierle, H. E., Norton, J., March, R. E., Santana, R., Deycke, K. H., Baruth, B., Weibbarth, E., Zeller, H., Ebringer, A., Geissler, N., Hildebrand, S., Kemper, A., Krapf, E., Renger, D., Schedel, I., Zeidler, H., Mielke, H., Krauledat, P. B., Krapf, F. E., Baudner, S., Linhart, H., Kalden, J. R., Maddison, P. J., Skinner, R. P., Esscher, E., Taylor, P. V., Scott, O., Scott, J. S., Miossec, P., Youinou, P., Le Goff, P., Seigneurin, J. M., Coatalem, R., Trautmann, F., Arnold, W., Hermanns, Ph., Delanghe, J., Vansteenkiste, M., Mielants, H., Munthe, E., Jellum, E., Suykens, S., Schiller, H., Schilling, F., and Emrich, E.

Published
1983
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33. Zink

Author

Winchester, R., Yntema, L. F., Rasskin, L. D., Lurje, J. J., Nekljutina, W. F., Hibbard, P. L., Caldwell, J. R., Moyer, H. V., Ostroumow, E. A., Kolthoff, I. M., Pearson, E. B., Liebhafsky, H. A., Meyer, W. R., and Daniels, D. D.

Published
1939
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35. DRβ Chain Polymorphism in Pemphigus Vulgaris

Author

Gregersen, P. K., primary, Barr, K. M., additional, DeFeo, C., additional, Bystryn, C., additional, Franks, A., additional, Sanchez, B., additional, Silver, J., additional, Winchester, R. J., additional, and Nunez-Roldan, A., additional

Published
1989
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38. Oral Abstracts 7: RA Clinical * O37. Long-Term Outcomes of Early RA Patients Initiated with Adalimumab Plus Methotrexate Compared with Methotrexate Alone Following a Targeted Treatment Approach

Author

Fleischmann, R., primary, van Vollenhoven, R. F., additional, Smolen, J., additional, Emery, P., additional, Florentinus, S., additional, Rathmann, S., additional, Kupper, H., additional, Kavanaugh, A., additional, Taylor, P., additional, Genovese, M., additional, Keystone, E. C., additional, Drescher, E., additional, Berclaz, P.-Y., additional, Lee, C., additional, Fidelus-Gort, R., additional, Schlichting, D., additional, Beattie, S., additional, Luchi, M., additional, Macias, W., additional, Dikranian, A. H., additional, Alten, R., additional, Klearman, M., additional, Musselman, D., additional, Agarwal, S., additional, Green, J., additional, Gabay, C., additional, Weinblatt, M. E., additional, Schiff, M. H., additional, Fleischmann, R., additional, Valente, R., additional, van der Heijde, D., additional, Citera, G., additional, Zhao, C., additional, Maldonado, M. A., additional, Rakieh, C., additional, Nam, J. L., additional, Hunt, L., additional, Villeneuve, E., additional, Bissell, L.-A., additional, Das, S., additional, Conaghan, P., additional, McGonagle, D., additional, Wakefield, R. J., additional, Wright, H. L., additional, Thomas, H. B., additional, Moots, R., additional, Edwards, S. W., additional, Hamann, P., additional, Heward, J., additional, McHugh, N., additional, Lindsay, M. A., additional, Haroon, M., additional, Giles, J. T., additional, Winchester, R., additional, FitzGerald, O., additional, Karaderi, T., additional, Cohen, C. J., additional, Keidel, S., additional, Appleton, L. H., additional, Macfarlane, G. J., additional, Siebert, S., additional, Evans, D., additional, Paul Wordsworth, B., additional, Plant, D., additional, Bowes, J., additional, Orozco, G., additional, Morgan, A. W., additional, Wilson, A. G., additional, Isaacs, J., additional, Barton, A., additional, Williams, F. M., additional, Livshits, G., additional, Spector, T., additional, MacGregor, A., additional, Scollen, S., additional, Cao, D., additional, Memari, Y., additional, Hyde, C. L., additional, Zhang, B., additional, Sidders, B., additional, Ziemek, D., additional, Shi, Y., additional, Harris, J., additional, Harrow, I., additional, Dougherty, B., additional, Malarstig, A., additional, McEwen, R., additional, Stephens, J. L., additional, Patel, K., additional, Shin, S.-Y., additional, Surdulescu, G., additional, He, W., additional, Jin, X., additional, McMahon, S. B., additional, Soranzo, N., additional, John, S., additional, Wang, J., additional, Spector, T. D., additional, Baker, J., additional, Litherland, G. J., additional, Rowan, A. D., additional, Kite, K. A., additional, Bayley, R., additional, Yang, P., additional, Smith, J. P., additional, Williams, J., additional, Harper, L., additional, Kitas, G. D., additional, Buckley, C., additional, Young, S. P., additional, Fitzpatrick, M. A., additional, McGettrick, H. M., additional, Filer, A., additional, Raza, K., additional, Nash, G., additional, Muthana, M., additional, Davies, H., additional, Khetan, S., additional, Adeleke, G., additional, Hawtree, S., additional, Tazzyman, S., additional, Morrow, F., additional, Ciani, B., additional, Wilson, G., additional, Quirke, A.-M., additional, Lugli, E., additional, Wegner, N., additional, Charles, P., additional, Hamilton, B., additional, Chowdhury, M., additional, Ytterberg, J., additional, Potempa, J., additional, Fisher, B., additional, Thiele, G., additional, Mikuls, T., additional, Venables, P., additional, Adebajo, A. O., additional, Mease, P., additional, Gomez-Reino, J. J., additional, Wollenhaupt, J., additional, Hu, C., additional, Stevens, R., additional, Sieper, J., additional, Dougados, M., additional, Van den Bosch, F., additional, Goupille, P., additional, Rathmann, S. S., additional, Pangan, A. L., additional, Maksymowych, W. P., additional, Brown, M. A., additional, Elewaut, D., additional, Anderson, J., additional, Ramasamy, P., additional, O'Rourke, M., additional, Murphy, C., additional, Fitzgerald, O., additional, Jani, M., additional, Moore, S., additional, Mirjafari, H., additional, Macphie, E., additional, Chinoy, H., additional, Rao, C., additional, McLoughlin, Y., additional, and Preeti, S., additional

Published
2013
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44. CALCIUM OXALATE CARRIER PRECIPITATION OF Pu

Author

Maraman, W, primary, Beaumont, A, additional, Christensen, E, additional, Hendrickson, A, additional, Hermann, J, additional, Johnson, K, additional, Mullins, L, additional, and Winchester, R, additional

Published
1954
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47. Influence of HLA Alleles on the Rate of Progression of Vertically Transmitted HIV Infection in Children: Association of Several HLA-DR13 Alleles with Long-Term Survivorship and the Potential Association of HLA-A2301 with Rapid Progression to AIDS

Author

Chen, Y, primary, Winchester, R, additional, Korber, B, additional, Gagliano, J, additional, Bryson, Y, additional, Hutto, C, additional, Martin, N, additional, McSherry, G, additional, Petru, A, additional, Wara, D, additional, and Ammann, A, additional

Published
1997
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