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573 results on '"Winkelman, John W."'

1. Contributors

Author

Acampora, Gregory Alexander, primary, Ahmad, Zeba N., additional, Alpay, Menekse, additional, Alpert, Jonathan E., additional, Babadi, Baktash, additional, Baek, Ji Hyun, additional, Baig, Mizra, additional, Bains, Ashika, additional, Baker, Amanda Waters, additional, Baldi, Olivia, additional, Beach, Scott R., additional, Beck, BJ, additional, Beckwith, Noor, additional, Benedek, David M., additional, Beresin, Eugene V., additional, Biederman, Joseph, additional, Bird, Suzanne A., additional, Blais, Mark A., additional, Bosson, Rahel, additional, Brendel, Rebecca Weintraub, additional, Bui, Eric, additional, Camprodon, Joan A., additional, Capawana, Michael R., additional, Caplan, Jason P., additional, Carter, Christopher, additional, Cassano, Paolo, additional, Cather, Corinne, additional, Celano, Christopher M., additional, Chang, Trina E., additional, Charoenpong, Prangthip, additional, Chemali, Zeina N., additional, Chen, Justin, additional, Chopra, Amit, additional, Choukas, Nathaniel, additional, Chung, Sun Young, additional, Cohen, Jonah, additional, Cohen, Lee S., additional, Colvin, Mary K. (Molly), additional, Conteh, Nkechi, additional, Crain, Laura D., additional, Cremens, M. Cornelia, additional, Cusin, Cristina, additional, Dekel, Sharon, additional, Denysenko, Lex, additional, Dickerson, Bradford C., additional, Donovan, Abigail L., additional, Doorley, James, additional, Dougherty, Darin D., additional, Ducharme, Simon, additional, Eddy, Kamryn T., additional, Edersheim, Judith G., additional, Evanoff, Anastasia B., additional, Fava, Maurizio, additional, Finn, Christine T., additional, Fernandez-Robles, Carlos, additional, Fishel, Anne K., additional, Forchelli, Gina, additional, Freudenreich, Oliver, additional, Fricchione, Gregory L., additional, Friedman, Nora D.B., additional, Gatchel, Jennifer R., additional, Gelaye, Bizu, additional, Georgiopoulos, Anna M., additional, Ghaznavi, Sharmin, additional, Ginsburg, Richard, additional, Gold, Alexandra K., additional, Gordon, Christopher D., additional, Gray, Caroline A., additional, Greenberg, Donna B., additional, Greer, Joseph, additional, Hazen, Eric P., additional, Henry, Michael E., additional, Herman, John B., additional, Himes, Susan, additional, Hogan, Charlotte, additional, Holt, Daphne J., additional, Huffman, Jeffery C., additional, Huguenel, Brynn, additional, Ipek, Simay, additional, Irwin, Kelly Edwards, additional, Ivkovic, Ana, additional, Jacobs, Jamie, additional, Jagodnik, Kathleen M., additional, Jain, Felipe A., additional, Jankauskaite, Greta, additional, Januzzi, James L., additional, Jenike, Michael A., additional, Jenkins, Jonathan, additional, Johnson, Justin M., additional, Julian, John N., additional, Kamali, Masoud, additional, Kaneko, Yoshio A., additional, Katz, Tamar C., additional, Keuroghlian, Alex, additional, Keuthen, Nancy J., additional, Khoshbin, Shahram, additional, Kim, Hyun-Hee, additional, Kim, Youngjung R., additional, Koh, Katherine A., additional, Kohrman, Samuel I., additional, Kontos, Nicholas, additional, Lagomasino, Isabel T., additional, Leval, Rebecca, additional, Leveroni, Catherine, additional, Lim, Carol, additional, Luccarelli, James, additional, Madarasmi, Saira, additional, Madva, Elizabeth N., additional, McCoy, Thomas H., additional, Milosavljevic, Nada, additional, Mischoulon, David, additional, Miyares, Peyton, additional, Morelli, Leah W., additional, Rodriguez, Alejandra E. Morfin, additional, Murray, Evan D., additional, Murray, Helen Burton, additional, Nejad, Shamim H., additional, Newhouse, Amy L., additional, Nicolson, Stephen E., additional, Nierenberg, Andrew A., additional, Nisavic, Mladen, additional, Nonacs, Ruta M., additional, Öngür, Dost, additional, Onyeaka, Henry, additional, Orr, Scott P., additional, Ostacher, Michael J., additional, Pace-Schott, Edward F., additional, Papakostas, George I., additional, Paudel, Shreedhar, additional, Peay, Celeste, additional, Pederson, Aderonke Bamgbose, additional, Penava, Susan J., additional, Perez, David L., additional, Perlis, Roy H., additional, Peters, Amy T., additional, Pinsky, Elizabeth G., additional, Pollak, Lauren Norton, additional, Pollastri, Alisha R., additional, Post, Loren M., additional, Powell, Alicia D., additional, Prager, Laura M., additional, Praschan, Nathan, additional, Price, Bruce H., additional, Prince, Jefferson B., additional, Probert, Julia M., additional, Prom, Maria C., additional, Punko, Diana, additional, Rauch, Scott L., additional, Raviola, Giuseppe J., additional, Reilly-Harrington, Noreen A., additional, Ritchie, Elspeth Cameron, additional, Rivas-Vazquez, Rafael, additional, Robinson, Ellen M., additional, Roffman, Joshua L., additional, Rubin, David H., additional, Ruchensky, Jared R., additional, Salvi, Joshua D., additional, Sanders, Kathy M., additional, Sanders, Wesley M., additional, Schlozman, Steven C., additional, Schouten, Ronald, additional, Schuster, Randi, additional, Shafer, Linda C., additional, Sheets, Jennifer, additional, Sher, Yelizaveta, additional, Sherman, Janet Cohen, additional, Sinclair, Samuel Justin, additional, Smith, Felicia A., additional, Sockalingam, Sanjeev, additional, Sogg, Stephanie, additional, Sorg, Emily M., additional, Sprich, Susan E., additional, Stein, Michelle B., additional, Stern, Theodore A., additional, Stoler, Joan M., additional, Stone, Mira, additional, Surman, Craig B.H., additional, Sylvia, Louisa G., additional, Tanev, Kaloyan S., additional, Tayeb, Haythum O., additional, Taylor, John B., additional, Thom, Robyn P., additional, Thomas, Jennifer J., additional, Tillman, Emma M., additional, Traeger, Lara, additional, Trinh, Nhi-Ha, additional, Uchida, Mai, additional, Ulman, Kathleen Hubbs, additional, Valera, Eve M., additional, Van Alphen, Manjola U., additional, Vazquez, Rafael, additional, Viguera, Adele C., additional, Wang, Betty, additional, Weilburg, Jeffrey B., additional, Weinberg, Marc, additional, Weinstein, Sylvie J., additional, Weisholtz, Daniel, additional, Wilens, Timothy E., additional, Wilhelm, Sabine, additional, Winkelman, John W., additional, Wright, Christopher L., additional, Wynn, Gary H., additional, Yeung, Albert, additional, Zakhary, Lisa, additional, and Zambrano, Juliana, additional

Published
2025
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2. Sleep Disorders

Author

Chopra, Amit, primary, Weilburg, Jeffrey B., additional, and Winkelman, John W., additional

Published
2025
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4. Long-Term Use of Insomnia Medications: An Appraisal of the Current Clinical and Scientific Evidence

Author

Zee, Phyllis C, Bertisch, Suzanne M, Morin, Charles M, Pelayo, Rafael, Watson, Nathaniel F, Winkelman, John W, and Krystal, Andrew D

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Research, Sleep Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, clinical appraisal, insomnia, insomnia medications, long-term use, safety, Clinical Sciences, Biomedical and clinical sciences
Abstract

While evidence supports the benefits of medications for the treatment of chronic insomnia, there is ongoing debate regarding their appropriate duration of use. A panel of sleep experts conducted a clinical appraisal regarding the use of insomnia medications, as it relates to the evidence supporting the focus statement, "No insomnia medication should be used on a daily basis for durations longer than 3 weeks at a time". The panelists' assessment was also compared to findings from a national survey of practicing physicians, psychiatrists, and sleep specialists. Survey respondents revealed a wide range of opinions regarding the appropriateness of using the US Food and Drug Administration (FDA)-approved medications for the treatment of insomnia lasting more than 3 weeks. After discussion of the literature, the panel unanimously agreed that some classes of insomnia medications, such as non-benzodiazepines hypnotics, have been shown to be effective and safe for long-term use in the appropriate clinical setting. For eszopiclone, doxepin, ramelteon and the newer class of dual orexin receptor antagonists, the FDA label does not specify that their use should be of a limited duration. Thus, an evaluation of evidence supporting the long-term safety and efficacy of newer non-benzodiazepine hypnotics is timely and should be considered in practice recommendations for the duration of pharmacologic treatment of chronic insomnia.

Published
2023

5. Do Insomnia Treatments Improve Daytime Function?

Author

Watson, Nathaniel F, Bertisch, Suzanne M, Morin, Charles M, Pelayo, Rafael, Winkelman, John W, Zee, Phyllis C, and Krystal, Andrew D

Subjects
Biomedical and Clinical Sciences, Clinical Research, Sleep Research, insomnia, medications, daytime function, clinical appraisal, Clinical Sciences, Biomedical and clinical sciences
Abstract

A scientific advisory panel of seven U.S. and Canadian sleep experts performed a clinical appraisal by comparing general medical opinion, assessed via a survey of practicing clinicians, regarding insomnia treatment, with the available scientific evidence. This clinical appraisal focuses on the specific statement, "Treatments for insomnia have uniformly been shown to significantly improve the associated daytime impairment seen with insomnia." The advisory panel reviewed and discussed the available body of evidence within the published medical literature to determine what discrepancies may exist between the currently published evidence base and general medical opinion. The advisory panels' evaluation of this statement was also compared with the results of a national survey of primary care physicians, psychiatrists, nurse practitioners, physician assistants, and sleep specialists in the United States. Contrary to general medical opinion, the expert advisory panel concluded that the medical literature did not support the statement. This gap highlights the need to educate the general medical community regarding insomnia treatment efficacy in pursuit of improved treatment outcomes.

Published
2023

6. Should Trazodone Be First-Line Therapy for Insomnia? A Clinical Suitability Appraisal

Author

Pelayo, Rafael, Bertisch, Suzanne M, Morin, Charles M, Winkelman, John W, Zee, Phyllis C, and Krystal, Andrew D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Sleep Research, insomnia, trazodone, clinical appraisal, literature review, Biomedical and clinical sciences
Abstract

Trazodone is one of the most commonly used prescription medications for insomnia; however, some recent clinical guidelines do not recommend its use for treating insomnia. This clinical appraisal critically reviews the scientific literature on trazodone as a first-line treatment for insomnia, with the focus statement "Trazodone should never be used as a first-line medication for insomnia." In addition, field surveys were sent to practicing physicians, psychiatrists, and sleep specialists to assess general support for this statement. Subsequently, a meeting with a seven-member panel of key opinion leaders was held to discuss published evidence in support and against the statement. This paper reports on the evidence review, the panel discussion, and the panel's and healthcare professionals' ratings of the statement's acceptability. While the majority of field survey responders disagreed with the statement, the majority of panel members agreed with the statement based on the limited published evidence supporting trazodone as a first-line agent as they understood the term "first-line agent".

Published
2023

7. What Should Be the Focus of Treatment When Insomnia Disorder Is Comorbid with Depression or Anxiety Disorder?

Author

Morin, Charles M, Bertisch, Suzanne M, Pelayo, Rafael, Watson, Nathaniel F, Winkelman, John W, Zee, Phyllis C, and Krystal, Andrew D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Mind and Body, Brain Disorders, Mental Health, Depression, Behavioral and Social Science, Clinical Research, Sleep Research, 6.6 Psychological and behavioural, Evaluation of treatments and therapeutic interventions, Mental health, Good Health and Well Being, sleep disturbances, treatment, pharmacological, cognitive-behavioral therapy comorbidity, psychiatric, depression, anxiety, clinical appraisal, Biomedical and clinical sciences
Abstract

Insomnia is a significant, highly prevalent, persistent public health problem but often remains undiagnosed and untreated. Current treatment practices are not always evidence-based. When insomnia is comorbid with anxiety or depression, treatment often targets that comorbid condition with the expectation that improvement of the mental health condition will generalize to sleep symptoms. An expert panel of seven members conducted a clinical appraisal of the literature regarding the treatment of insomnia when comorbid anxiety or depression are also present. The clinical appraisal consisted of the review, presentation, and assessment of current published evidence as it relates to the panel's predetermined clinical focus statement, "Whenever chronic insomnia is associated with another condition, such as anxiety or depression, that psychiatric condition should be the only focus of treatment as the insomnia is most likely a symptom of the condition". The results from an electronic national survey of US-based practicing physicians, psychiatrists, and sleep (N = 508) revealed that >40% of physicians agree "at least somewhat" that treatment of comorbid insomnia should focus solely on the psychiatric condition. Whereas 100% of the expert panel disagreed with the statement. Thus, an important gap exists between current clinical practices and evidence-based guidelines and more awareness is needed so that insomnia is treated distinctly from comorbid anxiety and depression.

Published
2023

11. Contributors

Author

Abbott, Sabra M., primary, Abe, Takashi, additional, Ali, Imran I., additional, Arnedt, J. Todd, additional, Avidan, Alon Y., additional, Bartsch, Ronny P., additional, Benca, Ruth M., additional, Buxton, Orfeu M., additional, Chang, Anne-Marie, additional, Chervin, Ronald D., additional, Collop, Nancy, additional, Corrigan, Jennifer, additional, Dinges, David F., additional, During, Emmanuel H., additional, Dutt, Mohan, additional, Eckert, Danny J., additional, Edinger, Jack D., additional, Eldridge-Smith, E. Devon, additional, Formentin, Chiara, additional, Fuller, Patrick M., additional, Geer, Jacqueline, additional, Goldstein, Cathy, additional, Hanly, Patrick J., additional, Harper, Ronald M., additional, Hirshkowitz, Max, additional, Howell, Michael J., additional, Ip, Mary S.M., additional, Irfan, Muna, additional, Ivanov, Plamen Ch., additional, Javaheri, Shahrokh, additional, Javaheri, Sogol, additional, Jones, Christopher W., additional, Ju, Yo-El S., additional, Kaizi-Lutu, Marc, additional, Kapas, Levente, additional, Kryger, Meir H., additional, Kutscher, Scott J., additional, Lee, Won Y., additional, Liu, Peter Y., additional, Lui, Macy M.S., additional, Lussier, Bethany L., additional, Malhotra, Atul, additional, Malhotra, Raman K., additional, McCall, Catherine A., additional, McCall, William V., additional, Mendelson, Wallace, additional, Montagnese, Sara, additional, Parmeggiani, Pier Luigi, additional, Prather, Aric A., additional, Reid, Kathryn J., additional, Roth, Thomas, additional, Schneider, Logan Douglas, additional, Shapiro, Colin M., additional, Sharafkhaneh, Amir, additional, Sheikh, Ajaz A., additional, Sheldon, Stephen H., additional, Sherman, Deena, additional, Siegel, Jerome M., additional, Spaeth, Andrea M., additional, Stickgold, Robert, additional, Summa, Keith C., additional, Swanson, Leslie, additional, Szentirmai, Éva, additional, Tobias, Lauren, additional, Turek, Fred W., additional, Turnbull, Christopher D., additional, Vaughn, Bradley V., additional, Verrier, Richard L., additional, Wamsley, Erin J., additional, West, Sophie D., additional, Whibley, Daniel, additional, Winkelman, John W., additional, Wojeck, Brian S., additional, Won, Christine H.J., additional, Yao, Steven, additional, Yuen, Kin M., additional, and Zee, Phyllis C., additional

Published
2024
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16. The Management of Restless Legs Syndrome: An Updated Algorithm

Author

Earley, Christopher J., Becker, Phillip, Berkowski, J. Andrew, Buchfuhrer, Mark J., Clemens, Stefan, Connor, James R., Ferré, Sergi, Hensley, Jennifer G., Jones, Byron C., Karroum, Elias G., Koo, Brian, Manconi, Mauro, Ondo, William, Richards, Kathy, Sharon, Denise, Silber, Michael H., Trotti, Lynn Marie, Uhl, George, Walters, Arthur S., Winkelman, John W., and Koo, Brian B.

Published
2021
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17. Associations of Incident Cardiovascular Events With Restless Legs Syndrome and Periodic Leg Movements of Sleep in Older Men, for the Outcomes of Sleep Disorders in Older Men Study (MrOS Sleep Study)

Author

Winkelman, John W, Blackwell, Terri, Stone, Katie, Ancoli-Israel, Sonia, and Redline, Susan

Subjects
Brain Disorders, Prevention, Cardiovascular, Aging, Neurosciences, Sleep Research, Heart Disease, Good Health and Well Being, Aged, Humans, Male, Movement, Myocardial Infarction, Polysomnography, Proportional Hazards Models, Restless Legs Syndrome, Risk Factors, Sleep, restless legs syndrome, periodic limb movements, coronary artery disease, insomnia, insomnia., Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Both restless legs syndrome (RLS) and periodic leg movements in sleep (PLMS) may be associated with incident cardiovascular disease (CVD). However, the individual contributions of these factors to adverse CVD outcomes are unknown. During the MrOS Sleep Study, 2823 men (mean age = 76.3 years) participated in a comprehensive sleep assessment from 2000 to 2002. RLS was identified by self-report of a physician diagnosis of RLS. A periodic limb movement of sleep index (PLMI) was derived from unattended in-home polysomnography. Incident cardiovascular events were centrally adjudicated during 8.7 ± 2.6 years of follow-up. The primary outcome was all-cause CVD; secondary outcomes included incident myocardial infarction (MI) and cerebrovascular disease. Cox proportional hazards regression models were adjusted for multiple covariates, including PLMI, to examine if there were independent associations of RLS and PLMI to the outcomes. Physician-diagnosed RLS was reported by 2.2% and a PLMI ≥ 15 was found in 59.6% of men. RLS was not associated with the composite CVD outcome. RLS was significantly associated with incident MI (Hazard ratio [HR] = 2.02, 95% CI, 1.04-3.91) even after adjustment for multiple covariates. Results were only modestly attenuated when PLMI was added to the model. PLMI also was found to predict incident MI (per SD increase in PLMI, HR = 1.14, 95% CI, 1.00-1.30, p = .05), and was materially unchanged after addition of RLS. The independent risk that RLS confers for MI suggests a role for non-PLMS factors such as sleep disturbance, shared genetic factors, or PLM-independent sympathetic hyperactivity.

Published
2017

28. Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids

Author

Cai, Ning-Sheng, Quiroz, Cesar, Bonaventura, Jordi, Bonifazi, Alessandro, Cole, Thomas O., Purks, Julia, Billing, Amy S., Massey, Ebonie, Wagner, Michael, Wish, Eric D., Guitart, Xavier, Rea, William, Lam, Sherry, Moreno, Estefania, Casado-Anguera, Veronica, Greenblatt, Aaron D., Jacobson, Arthur E., Rice, Kenner C., Casado, Vicent, Newman, Amy H., Winkelman, John W., Michaelides, Michael, Weintraub, Eric, Volkow, Nora D., Belcher, Annabelle M., and Ferre, Sergi

Subjects
Comparative analysis, Negotiation, mediation and arbitration, Health aspects, Neurophysiology -- Comparative analysis -- Health aspects, Morphine -- Comparative analysis -- Health aspects, Neuropeptides -- Comparative analysis -- Health aspects, Opioids, Legal liability
Abstract

Introduction The opioid epidemic represents a severe public health crisis (1). Maintenance treatment with the ^-opioid receptor (MOR) agonist methadone is the most highly researched and evidence-based treatment for opioid [...], Identifying nonaddictive opioid medications is a high priority in medical science, but [mu]-opioid receptors (MORs) mediate both the analgesic and addictive effects of opioids. We found a significant pharmacodynamic difference between morphine and methadone that is determined entirely by heteromerization of MORs with galanin Gal1 receptors (Gal1Rs), rendering a profound decrease in the potency of methadone. This finding was explained by the weaker proficiency of methadone in activating the dopaminergic system as compared with morphine and predicted a dissociation of the therapeutic and euphoric effects of methadone, which was corroborated by a significantly lower incidence of self-reports of feeling "high" in methadone-medicated patients. These results suggest that [mu]-opioid-Gal1R heteromers mediate the dopaminergic effects of opioids. The results further suggest a lower addictive liability of some opioids, such as methadone, due to their selective low potency for the [mu]-opioid-Gal1R heteromer.

Published
2019
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36. A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study

Author

Vlasac, Irma M, primary, Bormes, Gregory W, additional, Do, Elizabeth, additional, Benkhoukha, Selma S, additional, Diallo, Naby, additional, Fryou, Noah L, additional, Gioia, Siena, additional, Akeju, Oluwaseun, additional, Joseph, Clarence, additional, Kuan, Anne, additional, Lapan, Jennifer, additional, Oluwadara, David, additional, Team, the Pepper, additional, Rahman, Shadab A, additional, Saxena, Richa, additional, Scheer, Frank A J L, additional, Westover, M Brandon, additional, Winkelman, John W, additional, Woodson, Faraji, additional, and Lane, Jacqueline M, additional

Published
2023
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42. Guidelines for the first-line treatment of restless legs syndrome/Willis–Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation

Author

Garcia-Borreguero, Diego, Silber, Michael H., Winkelman, John W., Högl, Birgit, Bainbridge, Jacquelyn, Buchfuhrer, Mark, Hadjigeorgiou, Georgios, Inoue, Yuichi, Manconi, Mauro, Oertel, Wolfgang, Ondo, William, Winkelmann, Juliane, and Allen, Richard P.

Published
2016
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