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2 results on '"Winschel, Marlana B."'

1. B-cell–directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates

Author

Kaminski, James, Fleming, Ryan A., Alvarez-Calderon, Francesca, Winschel, Marlana B., McGuckin, Connor, Ho, Emily E., Eng, Fay, Rui, Xianliang, Keskula, Paula, Cagnin, Lorenzo, Charles, Joanne, Zavistaski, Jillian, Margossian, Steven P., Kapadia, Malika A., Rottman, James B., Lane, Jennifer, Baumeister, Susanne H. C., Tkachev, Victor, Shalek, Alex K., Kean, Leslie S., and Gerdemann, Ulrike

Published
2024
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2. B-cell–directed CAR T-cell therapy activates CD8+cytotoxic CARnegbystander T cells in patients and nonhuman primates

Author

Kaminski, James, Fleming, Ryan A., Alvarez-Calderon, Francesca, Winschel, Marlana B., McGuckin, Connor, Ho, Emily E., Eng, Fay, Rui, Xianliang, Keskula, Paula, Cagnin, Lorenzo, Charles, Joanne, Zavistaski, Jillian, Margossian, Steven P., Kapadia, Malika A., Rottman, James B., Lane, Jennifer, Baumeister, Susanne H. C., Tkachev, Victor, Shalek, Alex K., Kean, Leslie S., and Gerdemann, Ulrike

Abstract

•Transcriptomic analysis of NHP and patient-derived T cells following CAR T-cell infusion identified activated CAR−bystander CD8+T cells.•Cytokine exposure–induced bystander-like CD8+T cells capable of T-cell receptor–independent cytotoxic killing of leukemia cells.

Published
2024
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