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3,484 results on '"Wischnewski, A."'

2. Detection of the Crab Nebula using a Random Forest Analysis of the first TAIGA IACT Data

Author

Blank, M., Tluczykont, M., Porelli, A., Mirzoyan, R., Wischnewski, R., Awad, A. K., and Brueckner, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Tunka Advanced Instrument for Gamma- and cosmic-ray Astronomy (TAIGA) is a multicomponent experiment for the measurement of TeV to PeV gamma- and cosmic rays. Our goal is to establish a novel hybrid direct air shower technique, sufficient to access the energy domain of the long-sought Pevatrons. The hybrid air Cherenkov light detection technique combines the strengths of the HiSCORE shower front sampling array, and two $\thicksim$4 m class, $\sim$9.6 deg field of view Imaging Air Cherenkov Telescopes (IACTs). The HiSCORE array provides good angular and shower core position resolution, while the IACTs provide the image shape and orientation for gamma-hadron separation. In future, an additional muon detector will be used for hadron tagging at $\ge$ 100 TeV energies. Here, only data from the first IACT of the TAIGA experiment are used. A random forest algorithm was trained using Monte Carlo (MC) simulations and real data, and applied to 85 h of selected observational data tracking the Crab Nebula at a mean zenith angle of 33.5 deg, resulting in a threshold energy of 6 TeV for this dataset. The analysis was performed using the gammapy package. A total of 163.5 excess events were detected, with a statistical significance of 8.5 sigma. The observed spectrum of the Crab Nebula is best fit with a power law above 6 TeV with a flux normalisation of $(3.20\pm0.42)\cdot10^{-10} TeV^{-1} cm^{-2} s^{-1})$ at a reference energy of 13 TeV and a spectral index of $-2.74\pm0.16$., Comment: 8 pages, 9 figures, accepted by MNRAS

Published
2023
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4. Northern Gannet foraging trip length increases with colony size and decreases with latitude

Author

Bethany L. Clark, Freydís Vigfúsdóttir, Sarah Wanless, Keith C. Hamer, Thomas W. Bodey, Stuart Bearhop, Ashley Bennison, Jez Blackburn, Sam L. Cox, Kyle J. N. d’Entremont, Stefan Garthe, David Grémillet, Mark Jessopp, Jude Lane, Amélie Lescroël, William A. Montevecchi, David J. Pascall, Pascal Provost, Ewan D. Wakefield, Victoria Warwick‐Evans, Saskia Wischnewski, Lucy J. Wright, and Stephen C. Votier

Subjects
central place foraging, coloniality, species distributions, bio-logging, predator–prey, seabird, Science
Abstract

Density-dependent competition for food influences the foraging behaviour and demography of colonial animals, but how this influence varies across a species’ latitudinal range is poorly understood. Here we used satellite tracking from 21 Northern Gannet Morus bassanus colonies (39% of colonies worldwide, supporting 73% of the global population) during chick-rearing to test how foraging trip characteristics (distance and duration) covary with colony size (138–60 953 breeding pairs) and latitude across 89% of their latitudinal range (46.81–71.23° N). Tracking data for 1118 individuals showed that foraging trip duration and maximum distance both increased with square-root colony size. Foraging effort also varied between years for the same colony, consistent with a link to environmental variability. Trip duration and maximum distance also decreased with latitude, after controlling for colony size. Our results are consistent with density-dependent reduction in prey availability influencing colony size and reveal reduced competition at the poleward range margin. This provides a mechanism for rapid population growth at northern colonies and, therefore, a poleward shift in response to environmental change. Further work is required to understand when and how colonial animals deplete nearby prey, along with the positive and negative effects of social foraging behaviour.

Published
2024
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5. TUM autonomous motorsport: An autonomous racing software for the Indy Autonomous Challenge

Author

Betz, Johannes, Betz, Tobias, Fent, Felix, Geisslinger, Maximilian, Heilmeier, Alexander, Hermansdorfer, Leonhard, Herrmann, Thomas, Huch, Sebastian, Karle, Phillip, Lienkamp, Markus, Lohmann, Boris, Nobis, Felix, Ögretmen, Levent, Rowold, Matthias, Sauerbeck, Florian, Stahl, Tim, Trauth, Rainer, Werner, Frederik, and Wischnewski, Alexander

Subjects
Computer Science - Robotics
Abstract

For decades, motorsport has been an incubator for innovations in the automotive sector and brought forth systems like disk brakes or rearview mirrors. Autonomous racing series such as Roborace, F1Tenth, or the Indy Autonomous Challenge (IAC) are envisioned as playing a similar role within the autonomous vehicle sector, serving as a proving ground for new technology at the limits of the autonomous systems capabilities. This paper outlines the software stack and approach of the TUM Autonomous Motorsport team for their participation in the Indy Autonomous Challenge, which holds two competitions: A single-vehicle competition on the Indianapolis Motor Speedway and a passing competition at the Las Vegas Motor Speedway. Nine university teams used an identical vehicle platform: A modified Indy Lights chassis equipped with sensors, a computing platform, and actuators. All the teams developed different algorithms for object detection, localization, planning, prediction, and control of the race cars. The team from TUM placed first in Indianapolis and secured second place in Las Vegas. During the final of the passing competition, the TUM team reached speeds and accelerations close to the limit of the vehicle, peaking at around 270 km/h and 28 ms2. This paper will present details of the vehicle hardware platform, the developed algorithms, and the workflow to test and enhance the software applied during the two-year project. We derive deep insights into the autonomous vehicle's behavior at high speed and high acceleration by providing a detailed competition analysis. Based on this, we deduce a list of lessons learned and provide insights on promising areas of future work based on the real-world evaluation of the displayed concepts., Comment: 37 pages, 18 figures, 2 tables

Published
2022
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6. Cross-regional homeostatic and reactive glial signatures in multiple sclerosis

Author

Trobisch, Tim, Zulji, Amel, Stevens, Nikolas A, Schwarz, Sophia, Wischnewski, Sven, Öztürk, Mikail, Perales-Patón, Javier, Haeussler, Maximilian, Saez-Rodriguez, Julio, Velmeshev, Dmitry, and Schirmer, Lucas

Subjects
Biomedical and Clinical Sciences, Neurosciences, Neurodegenerative, Autoimmune Disease, Multiple Sclerosis, Human Genome, Genetics, Brain Disorders, 2.1 Biological and endogenous factors, Neurological, Astrocytes, Humans, Neuroglia, Oligodendroglia, RNA, White Matter, Single-nucleus RNA-sequencing, Glial heterogeneity, Oligodendrocytes, Lesion pathology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Multiple sclerosis (MS) is a multifocal and progressive inflammatory disease of the central nervous system (CNS). However, the compartmentalized pathology of the disease affecting various anatomical regions including gray and white matter and lack of appropriate disease models impede understanding of the disease. Utilizing single-nucleus RNA-sequencing and multiplex spatial RNA mapping, we generated an integrated transcriptomic map comprising leukocortical, cerebellar and spinal cord areas in normal and MS tissues that captures regional subtype diversity of various cell types with an emphasis on astrocytes and oligodendrocytes. While we found strong cross-regional diversity among glial subtypes in control tissue, regional signatures become more obscure in MS. This suggests that patterns of transcriptomic changes in MS are shared across regions and converge on specific pathways, especially those regulating cellular stress and immune activation. In addition, we found evidence that a subtype of white matter oligodendrocytes appearing across all three CNS regions adopt pro-remyelinating gene signatures in MS. In summary, our data suggest that cross-regional transcriptomic glial signatures overlap in MS, with different reactive glial cell types capable of either exacerbating or ameliorating pathology.

Published
2022

8. An electric field modeling study with meta-analysis to understand the antidepressant effects of transcranial direct current stimulation (tDCS)

Author

Lais B. Razza, Miles Wischnewski, Paulo Suen, Stefanie De Smet, Pedro Henrique Rodrigues da Silva, Beatriz Catoira, André R. Brunoni, and Marie-Anne Vanderhasselt

Subjects
Transcranial direct current stimulation, depression, computational modeling analysis, electric field, meta-analysis, major depressive disorder, dorsolateral prefrontal cortex, subgenual anterior cingulate cortex, Psychiatry, RC435-571
Abstract

Objective: Transcranial direct current stimulation (tDCS) has mixed effects for major depressive disorder (MDD) symptoms, partially owing to large inter-experimental variability in tDCS protocols and their correlated induced electric fields (E-fields). We investigated whether the E-field strength of distinct tDCS parameters was associated with antidepressant effect. Methods: A meta-analysis was performed with placebo-controlled clinical trials of tDCS enrolling MDD patients. PubMed, EMBASE, and Web of Science were searched from inception to March 10, 2023. Effect sizes of tDCS protocols were correlated with E-field simulations (SimNIBS) of brain regions of interest (bilateral dorsolateral prefrontal cortex [DLPFC] and bilateral subgenual anterior cingulate cortex [sgACC]). Moderators of tDCS responses were also investigated. Results: A total of 20 studies were included (21 datasets, 1,008 patients), using 11 distinct tDCS protocols. Results revealed a moderate effect for MDD (g = 0.41, 95%CI 0.18-0.64), while cathode position and treatment strategy were found to be moderators of response. A negative association between effect size and tDCS-induced E-field magnitude was seen, with stronger E-fields in the right frontal and medial parts of the DLPFC (targeted by the cathode) leading to smaller effects. No association was found for the left DLPFC and the bilateral sgACC. An optimized tDCS protocol is proposed. Conclusions: Our results highlight the need for a standardized tDCS protocol in MDD clinical trials. Registration number: PROSPERO CRD42022296246.

Published
2024
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9. Indy Autonomous Challenge -- Autonomous Race Cars at the Handling Limits

Author

Wischnewski, Alexander, Geisslinger, Maximilian, Betz, Johannes, Betz, Tobias, Fent, Felix, Heilmeier, Alexander, Hermansdorfer, Leonhard, Herrmann, Thomas, Huch, Sebastian, Karle, Phillip, Nobis, Felix, Ögretmen, Levent, Rowold, Matthias, Sauerbeck, Florian, Stahl, Tim, Trauth, Rainer, Lienkamp, Markus, and Lohmann, Boris

Subjects
Computer Science - Robotics, Computer Science - Artificial Intelligence
Abstract

Motorsport has always been an enabler for technological advancement, and the same applies to the autonomous driving industry. The team TUM Auton-omous Motorsports will participate in the Indy Autonomous Challenge in Octo-ber 2021 to benchmark its self-driving software-stack by racing one out of ten autonomous Dallara AV-21 racecars at the Indianapolis Motor Speedway. The first part of this paper explains the reasons for entering an autonomous vehicle race from an academic perspective: It allows focusing on several edge cases en-countered by autonomous vehicles, such as challenging evasion maneuvers and unstructured scenarios. At the same time, it is inherently safe due to the motor-sport related track safety precautions. It is therefore an ideal testing ground for the development of autonomous driving algorithms capable of mastering the most challenging and rare situations. In addition, we provide insight into our soft-ware development workflow and present our Hardware-in-the-Loop simulation setup. It is capable of running simulations of up to eight autonomous vehicles in real time. The second part of the paper gives a high-level overview of the soft-ware architecture and covers our development priorities in building a high-per-formance autonomous racing software: maximum sensor detection range, relia-ble handling of multi-vehicle situations, as well as reliable motion control under uncertainty.

Published
2022

10. V1405 Cas Nova 2021: About the nature of a multi-maxima nova

Author

Wischnewski, Erik

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

CONTEXT: The Nova V1405 Cas, which erupted on 18 March 2021, showed a pre-maximum phase of almost two months. After the main maximum, during several month the nova only weakened slightly and showed clear fluctuations in brightness. AIMS: The aim of this work is to investigate the relationship between brightness and half-width (FWHM) and equivalent width (EW) of the H-alpha emission line, and from this to infer possible causes for the abnormal behavior of the Nova. METHODS: Magnitudes and spectra from online databases were used, the H-alpha line of the spectra was measured and 2-day normal values were formed in order to establish a temporal comparison. RESULTS: After the main maximum, during the period investigated by JD 2459292 to 2459305 at intervals of 2-5 weeks secondary maxima with different characteristics. The maxima of the equivalent width were 6-14 days after the respective brightness maxima. The maxima are interpreted as subsequent outbreaks of the nova. Possibly these are subsequent weaker eruptions of the nova or other mechanisms that lead to an increase in density in the envelope.

Published
2021

12. Investigation of a fluorescent reporter microenvironment niche labeling strategy in experimental brain metastasis

Author

Matteo Massara, Bastien Dolfi, Vladimir Wischnewski, Emma Nolan, Werner Held, Ilaria Malanchi, and Johanna A. Joyce

Subjects
Microenvironment, Cell biology, Cancer, Science
Abstract

Summary: Brain metastases are the most common brain tumors in patients and are associated with poor prognosis. Investigating the colonization and outgrowth of brain metastases is challenging given the complexity of the organ, tissue sampling difficulty, and limited experimental models. To address this challenge, we employed a strategy to analyze the metastatic niche in established lesions, based on the release of a cell-penetrating mCherry tag from labeled tumor cells to neighboring niche cells, using different brain metastasis mouse models. We found that CD206+ macrophages were the most abundant cells taking up the mCherry label in established metastases. In vitro and in vivo experiments demonstrated that macrophages uptake and retain the canonical form of mCherry, even without the cell-penetrating portion of the tag. These results identify a specific macrophage subset in the brain that retains tumor-supplied fluorescent molecules, thereby complicating the long-term use of niche labeling strategies in established experimental brain metastasis.

Published
2024
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13. Search for Astrophysical Nanosecond Optical Transients with TAIGA-HiSCORE Array

Author

Panov, A. D., Astapov, I. I., Awad, A. K., Beskin, G. M., Bezyazeekov, P. A., Blank, M., Bonvech, E. A., Borodin, A. N., Bruckner, M., Budnev, N. M., Bulan, A. V., Chernov, D. V., Chiavassa, A., Dyachok, A. N., Gafarov, A. R., Garmash, A. Yu., Grebenyuk, V. M., Gress, O. A., Gress, T. I., Grinyuk, A. A., Grishin, O. G., Horns, D., Ivanova, A. L., Kalmykov, N. N., Kindin, V. V., Kiryuhin, S. N., Kokoulin, R. P., Kompaniets, K. G., Korosteleva, E. E., Kozhin, V. A., Kravchenko, E. A., Krivopalova, A. A., Kuzmichev, L. A., Kryukov, A. P., Lagutin, A. A., Lavrova, M. V., Lemeshev, Yu., Lubsandorzhiev, B. K., Lubsandorzhiev, N. B., Lukanov, A. D., Mirgazov, R. R., Mirzoyan, R., Monkhoev, R. D., Osipova, E. A., Pakhorukov, A. L., Pan, A., Pankov, L. V., Petrukhin, A. A., Podgrudkov, D. A., Poleschuk, V. A., Popova, E. G., Porelli, A., Postnikov, E. B., Prosin, V. V., Ptuskin, V. S., Pushnin, A. A., Raikin, R. I., Razumov, A., Rjabov, E., Rubtsov, G. I., Sagan, Y. I., Samoliga, V. S., Sidorenkov, A. Yu., Silaev, A. A., Skurikhin, A. V., Satyshev, I., Sokolov, A. V., Suvorkin, Y., Sveshnikova, L. G., Tabolenko, V. A., Tanaev, A. B., Tarashansky, B. A., Ternovoy, M., Tkachev, L. G., Tluczykont, M., Ushakov, N., Vaidyanathan, A., Volchugov, P. A., Volkov, N. V., Voronin, D., Wischnewski, R., Yashin, I. I., Zagorodnikov, A. V., and Zhurov, D. P.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

A wide-angle Cerenkov array TAIGA-HiSCORE (FOV $\sim$0.6 sr), was originally created as a part of TAIGA installation for high-energy gamma-ray astronomy and cosmic ray physics. Array now consist on nearly 100 optical stations on the area of 1 km$^2$. Due to high accuracy and stability ($\sim$1 ns) of time synchronization of the optical stations the accuracy of EAS arrival direction reconstruction is reached 0.1$^\mathrm{o}$. It was proven that the array can also be used to search for nanosecond events of the optical range. The report discusses the method of searching for optical transients using the HiSCORE array and demonstrates its performance on a real example of detecting signals from an artificial Earth satellite. The search for this short flares in the HiSCORE data of the winter season 2018--2019 is carried out. One candidate for double repeater has been detected, but the estimated probability of random simulation of such a transient by background EAS events is not less than 10%, which does not allow us to say that the detected candidate corresponds to a real astrophysical transient. An upper bound on the frequency of optical spikes with flux density of more than $10^{-4} \mathrm{erg/s/cm}^2$ and a duration of more than 5\,ns is established as $\sim 2 \times 10^{-3}$ events/sr/hour., Comment: 15 pages, 6 figures, reported at the conference ISCRA-2021, Accepted for publication in Physics of Atomic Nuclei

Published
2021
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15. In Seal We Trust? Investigating the Effect of Certifications on Perceived Trustworthiness of AI Systems

Author

Magdalena Wischnewski, Nicole Krämer, Christian Janiesch, Emmanuel Müller, Theodor Schnitzler, and Carina Newen

Subjects
artificial intelligence, seals of trust, epistemic trust, transparency, formal verification, Technology (General), T1-995, Oral communication. Speech, P95-95.6
Abstract

Trust certification through so-called trust seals is a common strategy to help users ascertain the trustworthiness of a system. In this study, we examined trust seals for AI systems from two perspectives: (1) In a pre-registered online study participants, we asked whether trust seals can increase user trust in AI systems, and (2) qualitatively, we investigated what participants expect from such AI seals of trust. Our results indicate mixed support for the use of AI seals. While trust seals generally did not affect the participants’ trust, their trust in the AI system increased if they trusted the seal-issuing institution. Moreover, although participants understood verification seals the least, they desired verifications of the AI system the most.

Published
2024
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16. Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation

Author

Wischnewski, Vladimir, Maas, Roeltje R., Aruffo, Paola Guerrero, Soukup, Klara, Galletti, Giovanni, Kornete, Mara, Galland, Sabine, Fournier, Nadine, Lilja, Johanna, Wirapati, Pratyaksha, Lourenco, Joao, Scarpa, Alice, Daniel, Roy T., Hottinger, Andreas F., Brouland, Jean-Philippe, Losurdo, Agnese, Voulaz, Emanuele, Alloisio, Marco, Hegi, Monika E., Lugli, Enrico, and Joyce, Johanna A.

Published
2023
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17. SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier

Author

Chiara Stüdle, Hideaki Nishihara, Sven Wischnewski, Laila Kulsvehagen, Sylvain Perriot, Hiroshi Ishikawa, Horst Schroten, Stephan Frank, Nikolaus Deigendesch, Renaud Du Pasquier, Lucas Schirmer, Anne-Katrin Pröbstel, and Britta Engelhardt

Subjects
SARS-CoV-2, Blood-brain barrier, Blood-cerebrospinal fluid barrier, hiPSC-derived brain microvascular endothelial cells, Choroid plexus epithelial cells, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background As a consequence of SARS-CoV-2 infection various neurocognitive and neuropsychiatric symptoms can appear, which may persist for several months post infection. However, cell type-specific routes of brain infection and underlying mechanisms resulting in neuroglial dysfunction are not well understood. Methods Here, we investigated the susceptibility of cells constituting the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) of the choroid plexus (ChP) to SARS-CoV-2 infection using human induced pluripotent stem cell (hiPSC)-derived cellular models and a ChP papilloma-derived epithelial cell line as well as ChP tissue from COVID-19 patients, respectively. Results We noted a differential infectibility of hiPSC-derived brain microvascular endothelial cells (BMECs) depending on the differentiation method. Extended endothelial culture method (EECM)-BMECs characterized by a complete set of endothelial markers, good barrier properties and a mature immune phenotype were refractory to SARS-CoV-2 infection and did not exhibit an activated phenotype after prolonged SARS-CoV-2 inoculation. In contrast, defined medium method (DMM)-BMECs, characterized by a mixed endothelial and epithelial phenotype and excellent barrier properties were productively infected by SARS-CoV-2 in an ACE2-dependent manner. hiPSC-derived brain pericyte-like cells (BPLCs) lacking ACE2 expression were not susceptible to SARS-CoV-2 infection. Furthermore, the human choroid plexus papilloma-derived epithelial cell line HIBCPP, modeling the BCSFB was productively infected by SARS-CoV-2 preferentially from the basolateral side, facing the blood compartment. Assessment of ChP tissue from COVID-19 patients by RNA in situ hybridization revealed SARS-CoV-2 transcripts in ChP epithelial and ChP stromal cells. Conclusions Our study shows that the BCSFB of the ChP rather than the BBB is susceptible to direct SARS-CoV-2 infection. Thus, neuropsychiatric symptoms because of COVID-19 may rather be associated with dysfunction of the BCSFB than the BBB. Future studies should consider a role of the ChP in underlying neuropsychiatric symptoms following SARS-CoV-2 infection.

Published
2023
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18. Snapping elastic disks as microswimmers: swimming at low Reynolds numbers by shape hysteresis

Author

Wischnewski, Christian and Kierfeld, Jan

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Fluid Dynamics
Abstract

We illustrate a concept for shape-changing microswimmers, which exploits the hysteresis of a shape transition of an elastic object, by an elastic disk undergoing cyclic localized swelling. Driving the control parameter of a hysteretic shape transition in a completely time-reversible manner gives rise to a non-time-reversible shape sequence and a net swimming motion if the elastic object is immersed into a viscous fluid. We prove this concept with a microswimmer which is a flat circular elastic disk that undergoes a transition into a dome-like shape by localized swelling of an inner disk. The control parameter of this shape transition is a scalar swelling factor of the disk material. With a fixed outer frame with an additional attractive interaction in the central region, the shape transition between flat and dome-like shape becomes hysteretic and resembles a hysteretic opening and closing of a scallop. Employing Stokesian dynamics simulations of a discretized version of the disk we show that the swimmer is effectively moving into the direction of the opening of the dome in a viscous fluid if the swelling parameter is changed in a time-reversible manner. The swimming mechanism can be qualitatively reproduced by a simple 9-bead model., Comment: 16 pages, 14 figures

Published
2020
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19. Real-Time Adaptive Velocity Optimization for Autonomous Electric Cars at the Limits of Handling

Author

Herrmann, Thomas, Wischnewski, Alexander, Hermansdorfer, Leonhard, Betz, Johannes, and Lienkamp, Markus

Subjects
Computer Science - Robotics, Electrical Engineering and Systems Science - Systems and Control
Abstract

With the evolution of self-driving cars, autonomous racing series like Roborace and the Indy Autonomous Challenge are rapidly attracting growing attention. Researchers participating in these competitions hope to subsequently transfer their developed functionality to passenger vehicles, in order to improve self-driving technology for reasons of safety, and due to environmental and social benefits. The race track has the advantage of being a safe environment where challenging situations for the algorithms are permanently created. To achieve minimum lap times on the race track, it is important to gather and process information about external influences including, e.g., the position of other cars and the friction potential between the road and the tires. Furthermore, the predicted behavior of the ego-car's propulsion system is crucial for leveraging the available energy as efficiently as possible. In this paper, we therefore present an optimization-based velocity planner, mathematically formulated as a multi-parametric Sequential Quadratic Problem (mpSQP). This planner can handle a spatially and temporally varying friction coefficient, and transfer a race Energy Strategy (ES) to the road. It further handles the velocity-profile-generation task for performance and emergency trajectories in real time on the vehicle's Electronic Control Unit (ECU).

Published
2020
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20. Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation

Author

Consortium, The Cherenkov Telescope Array, Abdalla, H., Abe, H., Acero, F., Acharyya, A., Adam, R., Agudo, I., Aguirre-Santaella, A., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., B, R. Alves, Amati, L., Amato, E., Ambrosi, G., Angüner, E. O., Araudo, A., Armstrong, T., Arqueros, F., Arrabito, L., Asano, K., Ascasíbar, Y., Ashley, M., Backes, M., Balazs, C., Balbo, M., Balmaverde, B., Larriva, A. Baquero, Martins, V. Barbosa, Barkov, M., Baroncelli, L., de Almeida, U. Barres, Barrio, J. A., Batista, P., Becerra, J., Becherini, Y., Beck, G., Tjus, J. Becker, Belmont, R., Benbow, W., Bernardini, E., Berti, A., Berton, M., Bertucci, B., Beshley, V., Bi, B., Biasuzzi, B., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Bocchino, F., Boisson, C., Bolmont, J., Bonanno, G., Arbeletche, L. Bonneau, Bonnoli, G., Bordas, P., Bottacini, E., Böttcher, M., Bozhilov, V., Bregeon, J., Brill, A., Brown, A. M., Bruno, P., Bruno, A., Bulgarelli, A., Burton, M., Buscemi, M., Caccianiga, A., Cameron, R., Capasso, M., Caprai, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Carosi, R., Carosi, A., Casanova, S., Cascone, E., Cauz, D., Cerny, K., Cerruti, M., Chadwick, P., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Chiavassa, A., Chytka, L., Conforti, V., Conte, F., Contreras, J. L., Coronado-Blazquez, J., Cortina, J., Costa, A., Costantini, H., Covino, S., Cristofari, P., Cuevas, O., D'Ammando, F., Daniel, M. K., Davies, J., Dazzi, F., De Angelis, A., de Lavergne, M. de Bony, De Caprio, V., Anjos, R. de Cássia dos, Pino, E. M. de Gouveia Dal, De Lotto, B., De Martino, D., de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., de Souza, V., Delgado, C., Della Ceca, R., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Pierro, F., Díaz, C., Díaz-Bahamondes, C., Diebold, S., Djannati-Ataï, A., Dmytriiev, A., Domínguez, A., Donini, A., Dorner, D., Doro, M., Dournaux, J., Dwarkadas, V. V., Ebr, J., Eckner, C., Einecke, S., Ekoume, T. R. N., Elsässer, D., Emery, G., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Fegan, S., Feng, Q., Ferrand, G., Fiandrini, E., Fiasson, A., Fioretti, V., Foffano, L., Fonseca, M. V., Font, L., Fontaine, G., Franco, F. J., Coromina, L. Freixas, Fukami, S., Fukazawa, Y., Fukui, Y., Gaggero, D., Galanti, G., Gammaldi, V., Garcia, E., Garczarczyk, M., Gascon, D., Gaug, M., Gent, A., Ghalumyan, A., Ghirlanda, G., Gianotti, F., Giarrusso, M., Giavitto, G., Giglietto, N., Giordano, F., Glicenstein, J., Goldoni, P., González, J. M., Gourgouliatos, K., Grabarczyk, T., Grandi, P., Granot, J., Grasso, D., Green, J., Grube, J., Gueta, O., Gunji, S., Halim, A., Harvey, M., Collado, T. Hassan, Hayashi, K., Heller, M., Cadena, S. Hernández, Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Hughes, G., Hütten, M., Iarlori, M., Inada, T., Inoue, S., Insolia, A., Ionica, M., Iori, M., Jacquemont, M., Jamrozy, M., Janecek, P., Martínez, I. Jiménez, Jin, W., Jung-Richardt, I., Jurysek, J., Kaaret, P., Karas, V., Karkar, S., Kawanaka, N., Kerszberg, D., Khélifi, B., Kissmann, R., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kong, A., Kosack, K., Kubo, H., La Palombara, N., Lamanna, G., Lang, R. G., Lapington, J., Laporte, P., Lemoine-Goumard, M., Lenain, J., Leone, F., Leto, G., Leuschner, F., Lindfors, E., Lloyd, S., Lohse, T., Lombardi, S., Longo, F., Lopez, A., López, M., López-Coto, R., Loporchio, S., Lucarelli, F., Luque-Escamilla, P. L., Lyard, E., Maggio, C., Majczyna, A., Makariev, M., Mallamaci, M., Mandat, D., Maneva, G., Manganaro, M., Manicò, G., Marcowith, A., Marculewicz, M., Markoff, S., Marquez, P., Martí, J., Martinez, O., Martínez, M., Martínez, G., Martínez-Huerta, H., Maurin, G., Mazin, D., Mbarubucyeye, J. D., Miranda, D. Medina, Meyer, M., Micanovic, S., Miener, T., Minev, M., Miranda, J. M., Mitchell, A., Mizuno, T., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Montaruli, T., Moralejo, A., Merino, J. Morales, Morcuende-Parrilla, D., Morselli, A., Mukherjee, R., Mundell, C., Murach, T., Muraishi, H., Nagai, A., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nievas, M., Nikołajuk, M., Nishijima, K., Noda, K., Nosek, D., Nozaki, S., O'Brien, P., Ohira, Y., Ohishi, M., Oka, T., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Osborne, J. P., Ostrowski, M., Oya, I., Pagliaro, A., Palatka, M., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pavletić, L., Pe'er, A., Pech, M., Pecimotika, M., Peresano, M., Persic, M., Petruk, O., Pfrang, K., Piatteli, P., Pietropaolo, E., Pillera, R., Pilszyk, B., Pimentel, D., Pintore, F., Pita, S., Pohl, M., Poireau, V., Polo, M., Prado, R. R., Prast, J., Principe, G., Produit, N., Prokoph, H., Prouza, M., Przybilski, H., Pueschel, E., Pühlhofer, G., Pumo, M. L., Punch, M., Queiroz, F., Quirrenbach, A., Rando, R., Razzaque, S., Rebert, E., Recchia, S., Reichherzer, P., Reimer, O., Reimer, A., Renier, Y., Reposeur, T., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Ramirez, J. C. Rodriguez, Vázquez, J. J. Rodríguez, Romano, P., Romeo, G., Roncadelli, M., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Rujopakarn, W., Russo, F., Sadeh, I., Saha, L., Saito, T., Greus, F. Salesa, Sanchez, D., Sánchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santos, E. M., Sanuy, A., Sarkar, S., Saturni, F. G., Sawangwit, U., Scherer, A., Schleicher, B., Schovanek, P., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Arroyo, M. Seglar, Sergijenko, O., Servillat, M., Seweryn, K., Shalchi, A., Sharma, P., Shellard, R. C., Siejkowski, H., Sinha, A., Sliusar, V., Slowikowska, A., Sokolenko, A., Sol, H., Specovius, A., Spencer, S., Spiga, D., Stamerra, A., Stanič, S., Starling, R., Stolarczyk, T., Straumann, U., Strišković, J., Suda, Y., Świerk, P., Tagliaferri, G., Takahashi, H., Takahashi, M., Tavecchio, F., Taylor, L., Tejedor, L. A., Temnikov, P., Terrier, R., Terzic, T., Testa, V., Tian, W., Tibaldo, L., Tonev, D., Torres, D. F., Torresi, E., Tosti, L., Tothill, N., Tovmassian, G., Travnicek, P., Truzzi, S., Tuossenel, F., Umana, G., Vacula, M., Vagelli, V., Valentino, M., Vallage, B., Vallania, P., van Eldik, C., Varner, G. S., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Veh, J., Vercellone, S., Vergani, S., Verguilov, V., Vettolani, G. P., Viana, A., Vigorito, C. F., Vitale, V., Vorobiov, S., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Watson, J., White, M., White, R., Wiemann, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Wolter, A., Yamazaki, R., Yanagita, S., Yang, L., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zaric, D., Zavrtanik, M., Zavrtanik, D., Zech, A., Zechlin, H., Zhdanov, V. I., and Živec, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Cherenkov Telescope Array (CTA), the new-generation ground-based observatory for $\gamma$-ray astronomy, provides unique capabilities to address significant open questions in astrophysics, cosmology, and fundamental physics. We study some of the salient areas of $\gamma$-ray cosmology that can be explored as part of the Key Science Projects of CTA, through simulated observations of active galactic nuclei (AGN) and of their relativistic jets. Observations of AGN with CTA will enable a measurement of $\gamma$-ray absorption on the extragalactic background light with a statistical uncertainty below 15% up to a redshift $z=2$ and to constrain or detect $\gamma$-ray halos up to intergalactic-magnetic-field strengths of at least 0.3pG. Extragalactic observations with CTA also show promising potential to probe physics beyond the Standard Model. The best limits on Lorentz invariance violation from $\gamma$-ray astronomy will be improved by a factor of at least two to three. CTA will also probe the parameter space in which axion-like particles could constitute a significant fraction, if not all, of dark matter. We conclude on the synergies between CTA and other upcoming facilities that will foster the growth of $\gamma$-ray cosmology., Comment: 71 pages (including affiliations and references), 13 figures, 6 tables. Accepted in JCAP; matches published version. Corresponding authors: Jonathan Biteau, Julien Lefaucheur, Humberto Martinez-Huerta, Manuel Meyer, Santiago Pita, Ievgen Vovk

Published
2020
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21. Sensitivity of the Cherenkov Telescope Array to a dark matter signal from the Galactic centre

Author

Consortium, The Cherenkov Telescope Array, Acharyya, A., Adam, R., Adams, C., Agudo, I., Aguirre-Santaella, A., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Batista, R. Alves, Amati, L., Ambrosi, G., Angüner, E. O., Antonelli, L. A., Aramo, C., Araudo, A., Armstrong, T., Arqueros, F., Asano, K., Ascasíbar, Y., Ashley, M., Balazs, C., Ballester, O., Larriva, A. Baquero, Martins, V. Barbosa, Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Becerra, J., Beck, G., Tjus, J. Becker, Benbow, W., Benito, M., Berge, D., Bernardini, E., Bernlöhr, K., Berti, A., Bertucci, B., Beshley, V., Biasuzzi, B., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Arbeletche, L. Bonneau, Bordas, P., Bosnjak, Z., Bottacini, E., Bozhilov, V., Bregeon, J., Brill, A., Bringmann, T., Brown, A. M., Brun, P., Brun, F., Bruno, P., Bulgarelli, A., Burton, M., Burtovoi, A., Buscemi, M., Cameron, R., Capasso, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Carosi, R., Carosi, A., Casanova, S., Cascone, E., Cassol, F., Catalani, F., Cauz, D., Cerruti, M., Chadwick, P., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Chiavassa, A., Chikawa, M., Chudoba, J., Çolak, M., Conforti, V., Coniglione, R., Conte, F., Contreras, J. L., Coronado-Blazquez, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., D'Aì, A., D'Ammando, F., Damone, L. A., Daniel, M. K., Dazzi, F., De Angelis, A., De Caprio, V., Anjos, R. de Cássia dos, Pino, E. M. de Gouveia Dal, De Lotto, B., De Martino, D., Wilhelmi, E. de Oña, De Palma, F., de Souza, V., Delgado, C., Giler, A. G. Delgado, della Volpe, D., Depaoli, D., Di Girolamo, T., Di Pierro, F., Di Venere, L., Diebold, S., Dmytriiev, A., Domínguez, A., Donini, A., Doro, M., Ebr, J., Eckner, C., Edwards, T. D. P., Ekoume, T. R. N., Elsässer, D., Evoli, C., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrara, G., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Fontaine, G., Fornieri, O., Franco, F. J., Fukami, S., Fukui, Y., Gaggero, D., Galaz, G., Gammaldi, V., Garcia, E., Garczarczyk, M., Gascon, D., Gent, A., Ghalumyan, A., Gianotti, F., Giarrusso, M., Giavitto, G., Giglietto, N., Giordano, F., Giuliani, A., Glicenstein, J., Gnatyk, R., Goldoni, P., González, M. M., Gourgouliatos, K., Granot, J., Grasso, D., Green, J., Grillo, A., Gueta, O., Gunji, S., Halim, A., Hassan, T., Heller, M., Cadena, S. Hernández, Hiroshima, N., Hnatyk, B., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Hughes, G., Humensky, T. B., Hütten, M., Iarlori, M., Inada, T., Inoue, S., Iocco, F., Iori, M., Jamrozy, M., Janecek, P., Jin, W., Jouvin, L., Jurysek, J., Karukes, E., Katarzyński, K., Kazanas, D., Kerszberg, D., Kherlakian, M. C., Kissmann, R., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kubo, H., Kushida, J., Lamanna, G., Lapington, J., Laporte, P., de Oliveira, M. A. Leigui, Lenain, J., Leone, F., Leto, G., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., Lopez, A., López, M., López-Coto, R., Loporchio, S., Luque-Escamilla, P. L., Mach, E., Maggio, C., Maier, G., Mallamaci, M., de Almeida, R. Malta Nunes, Mandat, D., Manganaro, M., Mangano, S., Manicò, G., Marculewicz, M., Mariotti, M., Markoff, S., Marquez, P., Martí, J., Martinez, O., Martínez, M., Martínez, G., Martínez-Huerta, H., Maurin, G., Mazin, D., Mbarubucyeye, J. D., Miranda, D. Medina, Meyer, M., Miceli, M., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Mizuno, T., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Montaruli, T., Moralejo, A., Morcuende-Parrilla, D., Morselli, A., Mukherjee, R., Mundell, C., Nagai, A., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nikołajuk, M., Ninci, D., Noda, K., Nosek, D., Nozaki, S., Ohira, Y., Ohishi, M., Ohtani, Y., Oka, T., Okumura, A., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, S., Orlando, E., Ostrowski, M., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Pantaleo, F. R., Paredes, J. M., Pareschi, G., Parmiggiani, N., Patricelli, B., Pavletić, L., Pe'er, A., Pecimotika, M., Pérez-Romero, J., Persic, M., Petruk, O., Pfrang, K., Piano, G., Piatteli, P., Pietropaolo, E., Pillera, R., Pilszyk, B., Pintore, F., Pohl, M., Poireau, V., Prado, R. R., Prandini, E., Prast, J., Principe, G., Prokoph, H., Prouza, M., Przybilski, H., Pühlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Recchia, S., Reimer, O., Reisenegger, A., Renier, Y., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Rinchiuso, L., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Ramirez, J. C. Rodriguez, Rojas, G., Romano, P., Romeo, G., Rosado, J., Rowell, G., Rudak, B., Russo, F., Sadeh, I., Hatlen, E. Sæther, Safi-Harb, S., Greus, F. Salesa, Salina, G., Sanchez, D., Sánchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santos, E. M., Santos-Lima, R., Sanuy, A., Sarkar, S., Saturni, F. G., Sawangwit, U., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Seglar-Arroyo, M., Sergijenko, O., Servillat, M., Seweryn, K., Shalchi, A., Sharma, P., Shellard, R. C., Siejkowski, H., Silk, J., Siqueira, C., Sliusar, V., Słowikowska, A., Sokolenko, A., Sol, H., Spencer, S., Stamerra, A., Stanič, S., Starling, R., Stolarczyk, T., Straumann, U., Strišković, J., Suda, Y., Suomijarvi, T., Świerk, P., Tavecchio, F., Taylor, L., Tejedor, L. A., Teshima, M., Testa, V., Tibaldo, L., Peixoto, C. J. Todero, Tokanai, F., Tonev, D., Tosti, G., Tosti, L., Tothill, N., Truzzi, S., Travnicek, P., Vagelli, V., Vallage, B., Vallania, P., van Eldik, C., Vandenbroucke, J., Varner, G. S., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Vergani, S., Verna, G., Viana, A., Vigorito, C. F., Vink, J., Vitale, V., Vorobiov, S., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Watson, J., Weniger, C., White, R., White, M., Wiemann, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Yanagita, S., Yang, L., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zakaria, A. A., Zampieri, L., Zanin, R., Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., and Živec, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

We provide an updated assessment of the power of the Cherenkov Telescope Array (CTA) to search for thermally produced dark matter at the TeV scale, via the associated gamma-ray signal from pair-annihilating dark matter particles in the region around the Galactic centre. We find that CTA will open a new window of discovery potential, significantly extending the range of robustly testable models given a standard cuspy profile of the dark matter density distribution. Importantly, even for a cored profile, the projected sensitivity of CTA will be sufficient to probe various well-motivated models of thermally produced dark matter at the TeV scale. This is due to CTA's unprecedented sensitivity, angular and energy resolutions, and the planned observational strategy. The survey of the inner Galaxy will cover a much larger region than corresponding previous observational campaigns with imaging atmospheric Cherenkov telescopes. CTA will map with unprecedented precision the large-scale diffuse emission in high-energy gamma rays, constituting a background for dark matter searches for which we adopt state-of-the-art models based on current data. Throughout our analysis, we use up-to-date event reconstruction Monte Carlo tools developed by the CTA consortium, and pay special attention to quantifying the level of instrumental systematic uncertainties, as well as background template systematic errors, required to probe thermally produced dark matter at these energies. "Full likelihood tables complementing our analysis are provided here [ https://doi.org/10.5281/zenodo.4057987 ]", Comment: 68 pages (including references) and 26 figures; text identical to the version published in JCAP

Published
2020
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22. The Disruptive Potential of FinTechs in the German Consumer Finance Sector -- A Blue Ocean Scenario?

Author

Wischnewski, Christian

Subjects
Computer Science - Computers and Society
Abstract

Using the Blue Ocean strategy as an underlying strategic element, this dissertation analyses whether this statement holds true for the rather more conservative banking sector in Germany and the overall risk-averse mindset of the German population by using both quantitative and qualitative elements to assess the current market share of FinTech companies in the Federal Republic, as well as grasp a potential outlook on the future development. A literature review of the strategic framework, the banking sector in Germany and the FinTech sector is carried out accordingly. Subsequently, a formal verification as to whether the banking sector is a "Red Ocean" and if the FinTech industry is a "Blue Ocean" is carried out using case studies from both sectors. A quantitative analysis of banking customers in Germany and their use of FinTech companies is conducted by way of an online survey, with selected participants being interviewed thereafter to gain additional insights. Data evaluation is made using pivotal analysis and cross tabulation of survey results and interview findings, along with extrapolating indicators to reflect the full size of the German banking sector and transactional volumes per segment are provided and examined for signs of elevated FinTech use in the market. Despite several limitations from where ideas for future research are derived, the outcomes provide an overview of existing trends for the use of FinTechs in Germany. The main finding is that with the notable exception of payment solutions, Germans do not have a high affinity towards FinTechs, rendering them a byproduct of the financial service industry, with limited market share and low potential., Comment: Master's Dissertation. 100 pages, 11 Figures, 24 Tables

Published
2020
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23. Multilayer Graph-Based Trajectory Planning for Race Vehicles in Dynamic Scenarios

Author

Stahl, Tim, Wischnewski, Alexander, Betz, Johannes, and Lienkamp, Markus

Subjects
Computer Science - Robotics, Electrical Engineering and Systems Science - Systems and Control
Abstract

Trajectory planning at high velocities and at the handling limits is a challenging task. In order to cope with the requirements of a race scenario, we propose a far-sighted two step, multi-layered graph-based trajectory planner, capable to run with speeds up to 212~km/h. The planner is designed to generate an action set of multiple drivable trajectories, allowing an adjacent behavior planner to pick the most appropriate action for the global state in the scene. This method serves objectives such as race line tracking, following, stopping, overtaking and a velocity profile which enables a handling of the vehicle at the limit of friction. Thereby, it provides a high update rate, a far planning horizon and solutions to non-convex scenarios. The capabilities of the proposed method are demonstrated in simulation and on a real race vehicle., Comment: Accepted at The 22nd IEEE International Conference on Intelligent Transportation Systems, October 27 - 30, 2019

Published
2020
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26. The local microenvironment drives activation of neutrophils in human brain tumors

Author

Maas, Roeltje R., Soukup, Klara, Fournier, Nadine, Massara, Matteo, Galland, Sabine, Kornete, Mara, Wischnewski, Vladimir, Lourenco, Joao, Croci, Davide, Álvarez-Prado, Ángel F., Marie, Damien N., Lilja, Johanna, Marcone, Rachel, Calvo, Gabriel F., Santalla Mendez, Rui, Aubel, Pauline, Bejarano, Leire, Wirapati, Pratyaksha, Ballesteros, Iván, Hidalgo, Andrés, Hottinger, Andreas F., Brouland, Jean-Philippe, Daniel, Roy T., Hegi, Monika E., and Joyce, Johanna A.

Published
2023
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27. The Southern Wide-Field Gamma-Ray Observatory (SWGO): A Next-Generation Ground-Based Survey Instrument for VHE Gamma-Ray Astronomy

Author

Abreu, P., Albert, A., Alfaro, R., Alvarez, C., Arceo, R., Assis, P., Barao, F., Bazo, J., Beacom, J. F., Bellido, J., BenZvi, S., Bretz, T., Brisbois, C., Brown, A. M., Brun, F., Buscemi, M., Mora, K. S. Caballero, Camarri, P., Carramiñana, A., Casanova, S., Chiavassa, A., Conceição, R., Cotter, G., Cristofari, P., Dasso, S., De Angelis, A., De Maria, M., Desiati, P., Di Sciascio, G., Vélez, J. C. Díaz, Dib, C., Dingus, B., Dorner, D., Doro, M., Duffy, C., DuVernois, M., Engel, R., Alonso, M. Fernandez, Fleischhack, H., Fonte, P., Fraija, N., Funk, S., García-González, J. A., González, M. M., Goodman, J. A., Greenshaw, T., Harding, J. P., Haungs, A., Hona, B., Huentemeyer, P., Insolia, A., Jardin-Blicq, A., Joshi, V., Kawata, K., Kunwar, S., La Mura, G., Lapington, J., Lenain, J. P., López-Coto, R., Malone, K., Martinez-Castro, J., Martínez-Huerta, H., Mendes, L., Moreno, E., Mostafá, M., Ng, K. C. Y., Nisa, M. U., Peron, F., Pichel, A., Pimenta, M., Prandini, E., Rainò, S., Reisenegger, A., Rodriguez, J., Roth, M., Rovero, A., Ruiz-Velasco, E., Sako, T., Sandoval, A., Santander, M., Satalecka, K., Schneider, M., Schoorlemmer, H., Schüssler, F., Shellard, R. C., Smith, A., Spencer, S., Springer, W., Surajbali, P., Tollefson, K., Tomé, B., Torres, I., Viana, A., Weisgarber, T., Wischnewski, R., Zepeda, A., Zhou, B., and Zhou, H.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We describe plans for the development of the Southern Wide-field Gamma-ray Observatory (SWGO), a next-generation instrument with sensitivity to the very-high-energy (VHE) band to be constructed in the Southern Hemisphere. SWGO will provide wide-field coverage of a large portion of the southern sky, effectively complementing current and future instruments in the global multi-messenger effort to understand extreme astrophysical phenomena throughout the universe. A detailed description of science topics addressed by SWGO is available in the science case white paper [1]. The development of SWGO will draw on extensive experience within the community in designing, constructing, and successfully operating wide-field instruments using observations of extensive air showers. The detector will consist of a compact inner array of particle detection units surrounded by a sparser outer array. A key advantage of the design of SWGO is that it can be constructed using current, already proven technology. We estimate a construction cost of 54M USD and a cost of 7.5M USD for 5 years of operation, with an anticipated US contribution of 20M USD ensuring that the US will be a driving force for the SWGO effort. The recently formed SWGO collaboration will conduct site selection and detector optimization studies prior to construction, with full operations foreseen to begin in 2026. Throughout this document, references to science white papers submitted to the Astro2020 Decadal Survey with particular relevance to the key science goals of SWGO, which include unveiling Galactic particle accelerators [2-10], exploring the dynamic universe [11-21], and probing physics beyond the Standard Model [22-25], are highlighted in red boldface., Comment: Astro2020 APC White Paper

Published
2019

28. Monte Carlo studies for the optimisation of the Cherenkov Telescope Array layout

Author

Acharyya, A., Agudo, I., Angüner, E. O., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Batista, R. Alves, Amans, J. -P., Amati, L., Amato, E., Ambrosi, G., Antonelli, L. A., Aramo, C., Armstrong, T., Arqueros, F., Arrabito, L., Asano, K., Ashkar, H., Balazs, C., Balbo, M., Balmaverde, B., Barai, P., Barbano, A., Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., González, J. Becerra, Tjus, J. Becker, Bellizzi, L., Benbow, W., Bernardini, E., Bernardos, M. I., Bernlöhr, K., Berti, A., Berton, M., Bertucci, B., Beshley, V., Biasuzzi, B., Bigongiari, C., Bird, R., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Boisson, C., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Bordas, P., Böttcher, M., Bregeon, J., Brill, A., Brown, A. M., Brügge, K., Brun, P., Bruno, P., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Cameron, R., Canestrari, R., Capalbi, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, R., Casanova, S., Cascone, E., Cassol, F., Catalani, F., Catalano, O., Cauz, D., Cerruti, M., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Cieślar, M., Colak, S. M., Conforti, V., Congiu, E., Contreras, J. L., Cortina, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cumani, P., Cusumano, G., D'Aì, A., D'Ammando, F., Dangeon, L., Da Vela, P., Dazzi, F., De Angelis, A., De Caprio, V., Anjos, R. de Cássia dos, De Frondat, F., Pino, E. M. de Gouveia Dal, De Lotto, B., De Martino, D., de Naurois, M., Wilhelmi, E. de Oña, de Palma, F., de Souza, V., Del Santo, M., Delgado, C., della Volpe, D., Di Girolamo, T., Di Pierro, F., Di Venere, L., Díaz, C., Diebold, S., Djannati-Ataï, A., Dmytriiev, A., Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Dournaux, J. -L., Ebr, J., Ekoume, T. R. N., Elsässer, D., Emery, G., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Flis, S., Fonseca, M. V., Fontaine, G., Coromina, L. Freixas, Fukami, S., Fukui, Y., Funk, S., Füßling, M., Gaggero, D., Galanti, G., López, R. J. Garcia, Garczarczyk, M., Gascon, D., Gasparetto, T., Gaug, M., Ghalumyan, A., Gianotti, F., Giavitto, G., Giglietto, N., Giordano, F., Giroletti, M., Gironnet, J., Glicenstein, J. -F., Gnatyk, R., Goldoni, P., González, J. M., González, M. M., Gourgouliatos, K. N., Grabarczyk, T., Granot, J., Green, D., Greenshaw, T., Grondin, M. -H., Gueta, O., Hadasch, D., Hassan, T., Hayashida, M., Heller, M., Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hofmann, W., Horvath, P., Hrabovsky, M., Hrupec, D., Humensky, T. B., Hütten, M., Inada, T., Iocco, F., Ionica, M., Iori, M., Iwamura, Y., Jamrozy, M., Janecek, P., Jankowsky, D., Jean, P., Jouvin, L., Jurysek, J., Kaaret, P., Kadowaki, L. H. S., Karkar, S., Kerszberg, D., Khélifi, B., Kieda, D., Kimeswenger, S., Kluźniak, W., Knapp, J., Knödlseder, J., Kobayashi, Y., Koch, B., Kocot, J., Komin, N., Kong, A., Kowal, G., Krause, M., Kubo, H., Kushida, J., Kushwaha, P., La Parola, V., La Rosa, G., Arquillo, M. Lallena, Lang, R. G., Lapington, J., Blanc, O. Le, Lefaucheur, J., de Oliveira, M. A. Leigui, Lemoine-Goumard, M., Lenain, J. -P., Leto, G., Lico, R., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., Lopez, A., López, M., Lopez-Oramas, A., López-Coto, R., Loporchio, S., Luque-Escamilla, P. L., Lyard, E., Maccarone, M. C., Mach, E., Maggio, C., Majumdar, P., Malaguti, G., Mallamaci, M., Mandat, D., Maneva, G., Manganaro, M., Mangano, S., Marculewicz, M., Mariotti, M., Martí, J., Martínez, M., Martínez, G., Martínez-Huerta, H., Masuda, S., Maxted, N., Mazin, D., Meunier, J. -L., Meyer, M., Micanovic, S., Millul, R., Minaya, I. A., Mitchell, A., Mizuno, T., Moderski, R., Mohrmann, L., Montaruli, T., Moralejo, A., Morcuende, D., Morlino, G., Morselli, A., Moulin, E., Mukherjee, R., Munar, P., Mundell, C., Murach, T., Nagai, A., Nagayoshi, T., Naito, T., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Ninci, D., Nishijima, K., Noda, K., Nosek, D., Nöthe, M., Nozaki, S., Ohishi, M., Ohtani, Y., Okumura, A., Ong, R. A., Orienti, M., Orito, R., Ostrowski, M., Otte, N., Ou, Z., Oya, I., Pagliaro, A., Palatiello, M., Palatka, M., Paoletti, R., Paredes, J. M., Pareschi, G., Parmiggiani, N., Parsons, R. D., Patricelli, B., Pe'er, A., Pech, M., Del Campo, P. Peñil, Pérez-Romero, J., Perri, M., Persic, M., Petrucci, P. -O., Petruk, O., Pfrang, K., Piel, Q., Pietropaolo, E., Pohl, M., Polo, M., Poutanen, J., Prandini, E., Produit, N., Prokoph, H., Prouza, M., Przybilski, H., Pühlhofer, G., Punch, M., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Reimer, O., Renault-Tinacci, N., Renier, Y., Ribeiro, D., Ribó, M., Rico, J., Rieger, F., Rizi, V., Fernandez, G. Rodriguez, Rodriguez-Ramirez, J. C., Vázquez, J. J. Rodríguez, Romano, P., Romeo, G., Roncadelli, M., Rosado, J., Rowell, G., Rudak, B., Rugliancich, A., Rulten, C., Sadeh, I., Saha, L., Saito, T., Sakurai, S., Greus, F. Salesa, Sangiorgi, P., Sano, H., Santander, M., Santangelo, A., Santos-Lima, R., Sanuy, A., Satalecka, K., Saturni, F. G., Sawangwit, U., Schlenstedt, S., Schovanek, P., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Sedlaczek, K., Seglar-Arroyo, M., Sergijenko, O., Seweryn, K., Shalchi, A., Shellard, R. C., Siejkowski, H., Sillanpää, A., Sinha, A., Sironi, G., Sliusar, V., Slowikowska, A., Sol, H., Specovius, A., Spencer, S., Spengler, G., Stamerra, A., Stanič, S., Stawarz, Ł., Stefanik, S., Stolarczyk, T., Straumann, U., Suomijarvi, T., Świerk, P., Szepieniec, T., Tagliaferri, G., Tajima, H., Tam, T., Tavecchio, F., Taylor, L., Tejedor, L. A., Temnikov, P., Terzic, T., Testa, V., Tibaldo, L., Peixoto, C. J. Todero, Tokanai, F., Tomankova, L., Tonev, D., Torres, D. F., Tosti, G., Tosti, L., Tothill, N., Toussenel, F., Tovmassian, G., Travnicek, P., Trichard, C., Umana, G., Vagelli, V., Valentino, M., Vallage, B., Vallania, P., Valore, L., Vandenbroucke, J., Varner, G. S., Vasileiadis, G., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Vercellone, S., Vergani, S., Vettolani, G. P., Viana, A., Vigorito, C. F., Vink, J., Vitale, V., Voelk, H., Vollhardt, A., Vorobiov, S., Wagner, S. J., Walter, R., Werner, F., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Yang, L., Yoshida, T., Yoshikoshi, T., Zacharias, M., Zampieri, L., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zenin, A., Zhdanov, V. I., Zimmer, S., and Zorn, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Cherenkov Telescope Array (CTA) is the major next-generation observatory for ground-based very-high-energy gamma-ray astronomy. It will improve the sensitivity of current ground-based instruments by a factor of five to twenty, depending on the energy, greatly improving both their angular and energy resolutions over four decades in energy (from 20 GeV to 300 TeV). This achievement will be possible by using tens of imaging Cherenkov telescopes of three successive sizes. They will be arranged into two arrays, one per hemisphere, located on the La Palma island (Spain) and in Paranal (Chile). We present here the optimised and final telescope arrays for both CTA sites, as well as their foreseen performance, resulting from the analysis of three different large-scale Monte Carlo productions., Comment: 48 pages, 16 figures, accepted for publication in Astroparticle Physics

Published
2019
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29. Tunka Advanced Instrument for cosmic rays and Gamma Astronomy

Author

Kostunin, D., Astapov, I., Bezyazeekov, P., Borodin, A., Budnev, N., Brückner, M., Chiavassa, A., Dyachok, A., Fedorov, O., Gafarov, A., Garmash, A., Grebenyuk, V., Gress, O., Gress, T., Grishin, O., Grinyuk, A., Haungs, A., Horns, D., Huege, T., Ivanova, A., Kalmykov, N., Kazarina, Y., Kindin, V., Kirilenko, P., Kiryuhin, S., Kleifges, M., Kokoulin, R., Kompaniets, K., Korosteleva, E., Kozhin, V., Kravchenko, E., Kuzmichev, A. Kryukov L., Lemeshev, Yu., Lagutin, A., Lenok, V., Lubsandorzhiev, B., Lubsandorzhiev, N., Marshalkina, T., Mirgazov, R., Mirzoyan, R., Monkhoev, R., Osipova, E., Pakhorukov, A., Pan, A., Panasyuk, M., Pankov, L., Petrukhin, A., Poleschuk, V., Popescu, M., Popova, E., Porelli, A., Postnikov, E., Prosin, V., Ptuskin, V., Pushnin, A., Raikin, R., Ryabov, E., Rubtsov, G., Sagan, Y., Sabirov, B., Samoliga, V., Semeney, Yu., Schröder, F. G., Silaev, A., Sidorenkov, A., Skurikhin, A., Slunecka, V., Sokolov, A., Spiering, C., Sveshnikova, L., Tabolenko, V., Tarashansky, B., Tkachev, L., Tluczykont, M., Ushakov, N., Volchugov, A. Vaidyanathan P., Voronin, D., Wischnewski, R., Zagorodnikov, A., Zhurov, D., Zurbanov, V., and Yashin, I.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The paper is a script of a lecture given at the ISAPP-Baikal summer school in 2018. The lecture gives an overview of the Tunka Advanced Instrument for cosmic rays and Gamma Astronomy (TAIGA) facility including historical introduction, description of existing and future setups, and outreach and open data activities., Comment: Lectures given at the ISAPP-Baikal Summer School 2018: Exploring the Universe through multiple messengers, 12-21 July 2018, Bol'shie Koty, Russia

Published
2019
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30. Strong deformation of ferrofluid-filled elastic alginate capsules in inhomogenous magnetic fields

Author

Wischnewski, Christian, Zwar, Elena, Rehage, Heinz, and Kierfeld, Jan

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Chemical Physics, Physics - Fluid Dynamics
Abstract

We present a new system based on alginate gels for the encapsulation of a ferrofluid drop, which allows us to create millimeter-sized elastic capsules that are highly deformable by inhomogeneous magnetic fields. We use a combination of experimental and theoretical work in order to characterize and quantify the deformation behavior of these ferrofluid-filled capsules. We introduce a novel method for the direct encapsulation of unpolar liquids by sodium alginate. The addition of polar alcohol molecules allows us to encapsulate a ferrofluid as a single phase. This encapsulation method increases the amount of encapsulated magnetic nanoparticles resulting in high deformations and offers possible applications of capsules as actuators, switches, or valves in confined spaces like microfluidic devices. We determine both elastic moduli of the capsule shell, Young's modulus and Poisson's ratio, by employing two independent mechanical methods, spinning capsule measurements and capsule compression between parallel plates. We then show that the observed magnetic deformation can be fully understood from magnetic forces exerted by the ferrofluid on the capsule shell if the magnetic field distribution and magnetization properties of the ferrofluid are known. Using an iterative solution scheme that couples a finite element / boundary element method for the magnetic field calculation to the solution of the elastic shape equations, we achieve quantitative agreement between theory and experiment for deformed capsule shapes using the Young modulus from mechanical characterization and the surface Poisson ratio as a fit parameter. This detailed analysis confirms the results from mechanical characterization that the surface Poisson ratio of the alginate shell is close to unity, that is, deformations of the alginate shell are almost area conserving.

Published
2019
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31. Science Case for a Wide Field-of-View Very-High-Energy Gamma-Ray Observatory in the Southern Hemisphere

Author

Albert, A., Alfaro, R., Ashkar, H., Alvarez, C., Álvarez, J., Arteaga-Velázquez, J. C., Solares, H. A. Ayala, Arceo, R., Bellido, J. A., BenZvi, S., Bretz, T., Brisbois, C. A., Brown, A. M., Brun, F., Caballero-Mora, K. S., Carosi, A., Carramiñana, A., Casanova, S., Chadwick, P. M., Cotter, G., De León, S. Coutiño, Cristofari, P., Dasso, S., de la Fuente, E., Dingus, B. L., Desiati, P., Salles, F. de O., de Souza, V., Dorner, D., Díaz-Vélez, J. C., García-González, J. A., DuVernois, M. A., Di Sciascio, G., Engel, K., Fleischhack, H., Fraija, N., Funk, S., Glicenstein, J-F., Gonzalez, J., González, M. M., Goodman, J. A., Harding, J. P., Haungs, A., Hinton, J., Hona, B., Hoyos, D., Huentemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kaufmann, S., Kawata, K., Kunwar, S., Lefaucheur, J., Lenain, J. -P., Link, K., López-Coto, R., Marandon, V., Mariotti, M., Martínez-Castro, J., Martínez-Huerta, H., Mostafá, M., Nayerhoda, A., Nellen, L., Wilhelmi, E. de Oña, Parsons, R. D., Patricelli, B., Pichel, A., Piel, Q., Prandini, E., Pueschel, E., Procureur, S., Reisenegger, A., Rivière, C., Rodriguez, J., Rovero, A. C., Rowell, G., Ruiz-Velasco, E. L., Sandoval, A., Santander, M., Sako, T., Sako, T. K., Satalecka, K., Schoorlemmer, H., Schüssler, F., Seglar-Arroyo, M., Smith, A. J., Spencer, S., Surajbali, P., Tabachnick, E., Taylor, A. M., Tibolla, O., Torres, I., Vallage, B., Viana, A., Watson, J. J., Weisgarber, T., Werner, F., White, R., Wischnewski, R., Yang, R., Zepeda, A., and Zhou, H.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We outline the science motivation for SGSO, the Southern Gamma-Ray Survey Observatory. SGSO will be a next-generation wide field-of-view gamma-ray survey instrument, sensitive to gamma-rays in the energy range from 100 GeV to hundreds of TeV. Its science topics include unveiling galactic and extragalactic particle accelerators, monitoring the transient sky at very high energies, probing particle physics beyond the Standard Model, and the characterization of the cosmic ray flux. SGSO will consist of an air shower detector array, located in South America. Due to its location and large field of view, SGSO will be complementary to other current and planned gamma-ray observatories such as HAWC, LHAASO, and CTA.

Published
2019

32. Gut microbiota–specific IgA+ B cells traffic to the CNS in active multiple sclerosis

Author

Pröbstel, Anne-Katrin, Zhou, Xiaoyuan, Baumann, Ryan, Wischnewski, Sven, Kutza, Michael, Rojas, Olga L, Sellrie, Katrin, Bischof, Antje, Kim, Kicheol, Ramesh, Akshaya, Dandekar, Ravi, Greenfield, Ariele L, Schubert, Ryan D, Bisanz, Jordan E, Vistnes, Stephanie, Khaleghi, Khashayar, Landefeld, James, Kirkish, Gina, Liesche-Starnecker, Friederike, Ramaglia, Valeria, Singh, Sneha, Tran, Edwina B, Barba, Patrick, Zorn, Kelsey, Oechtering, Johanna, Forsberg, Karin, Shiow, Lawrence R, Henry, Roland G, Graves, Jennifer, Cree, Bruce AC, Hauser, Stephen L, Kuhle, Jens, Gelfand, Jeffrey M, Andersen, Peter M, Schlegel, Jürgen, Turnbaugh, Peter J, Seeberger, Peter H, Gommerman, Jennifer L, Wilson, Michael R, Schirmer, Lucas, and Baranzini, Sergio E

Subjects
Biomedical and Clinical Sciences, Immunology, Multiple Sclerosis, Microbiome, Neurodegenerative, Neurosciences, Autoimmune Disease, Brain Disorders, 2.1 Biological and endogenous factors, Neurological, Inflammatory and immune system, Good Health and Well Being, Adult, Aged, Aged, 80 and over, B-Lymphocytes, Biomarkers, Biopsy, Brain, Case-Control Studies, Female, Gastrointestinal Microbiome, Humans, Immunity, Mucosal, Immunoglobulin A, Intestinal Mucosa, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Clinical sciences
Abstract

Changes in gut microbiota composition and a diverse role of B cells have recently been implicated in multiple sclerosis (MS), a central nervous system (CNS) autoimmune disease. Immunoglobulin A (IgA) is a key regulator at the mucosal interface. However, whether gut microbiota shape IgA responses and what role IgA+ cells have in neuroinflammation are unknown. Here, we identify IgA-bound taxa in MS and show that IgA-producing cells specific for MS-associated taxa traffic to the inflamed CNS, resulting in a strong, compartmentalized IgA enrichment in active MS and other neuroinflammatory diseases. Unlike previously characterized polyreactive anti-commensal IgA responses, CNS IgA cross-reacts with surface structures on specific bacterial strains but not with brain tissue. These findings establish gut microbiota-specific IgA+ cells as a systemic mediator in MS and suggest a critical role of mucosal B cells during active neuroinflammation with broad implications for IgA as an informative biomarker and IgA-producing cells as an immune subset to harness for therapeutic interventions.

Published
2020

35. Risk Awareness and Attitude of German Farmers towards Biosecurity Measures

Author

Anna Herrmann, Katja Schulz, Natalie Wischnewski, Jule Brüssau, Eva Zeiler, and Carola Sauter-Louis

Subjects
biosecurity, farm management, animal husbandry, farmer’s attitude, online-survey, Germany, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

The implementation of management activities depends on both the attitude of the people performing the work and their understanding of why the work should be performed. In the context of animal husbandry, the implementation of such practices is crucial for the functionality of biosecurity. Therefore, it is important to know how farmers perceive biosecurity as a whole. An anonymous online survey was conducted among German farmers. In addition to general data about their farm, information about their existing concept of biosecurity, as well as about the assessment of possible introduction routes for animal diseases into the farm with regard to their likelihood, was gathered. Furthermore, information on measures to protect their farm against disease introduction were retrieved. Analysis showed that in general, farmers were aware of the importance of biosecurity and consequently had concepts of biosecurity on their farms. However, awareness about dangerous introduction routes for animal diseases into a farm was associated with a lack of knowledge of how to improve the measures in these areas. The role of the veterinarian in the context of biosecurity was highlighted and further problematic areas were indicated. Overall, the high level of commitment from farmers indicated a good implementation of daily practices.

Published
2024
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37. Spheroidal and conical shapes of ferrofluid-filled capsules in magnetic fields

Author

Wischnewski, Christian and Kierfeld, Jan

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Fluid Dynamics
Abstract

We investigate the deformation of soft spherical elastic capsules filled with a ferrofluid in external uniform magnetic fields at fixed volume by a combination of numerical and analytical approaches. We develop a numerical iterative solution strategy based on nonlinear elastic shape equations to calculate the stretched capsule shape numerically and a coupled finite element and boundary element method to solve the corresponding magnetostatic problem, and employ analytical linear response theory, approximative energy minimization, and slender-body theory. The observed deformation behavior is qualitatively similar to the deformation of ferrofluid droplets in uniform magnetic fields. Homogeneous magnetic fields elongate the capsule, and a discontinuous shape transition from a spheroidal shape to a conical shape takes place at a critical field strength. We investigate how capsule elasticity modifies this hysteretic shape transition. We show that conical capsule shapes are possible but involve diverging stretch factors at the tips, which gives rise to rupture for real capsule materials. In a slender-body approximation we find that the critical susceptibility above which conical shapes occur for ferrofluid capsules is the same as for droplets. At small fields capsules remain spheroidal, and we characterize the deformation of spheroidal capsules both analytically and numerically. Finally, we determine whether wrinkling of a spheroidal capsule occurs during elongation in a magnetic field and how it modifies the stretching behavior. We find the nontrivial dependence between the extent of the wrinkled region and capsule elongation. Our results can be helpful in order to quantitatively determine capsule or ferrofluid material properties from magnetic deformation experiments. All results also apply to elastic capsules filled with a dielectric liquid in an external uniform electric field.

Published
2018
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39. The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation

Author

Malgorzata M. Duszczyk, Harry Wischnewski, Tamara Kazeeva, Rajika Arora, Fionna E. Loughlin, Christine von Schroetter, Ugo Pradère, Jonathan Hall, Constance Ciaudo, and Frédéric H.-T. Allain

Subjects
Science
Abstract

The authors report an unusual mode of AU-rich RNA recognition by the RNA recognition motifs of DND1, a protein essential for germline development, in a 27.5 kDa NMR structure and provide additional insight on DND1 function from cell-based experiments.

Published
2022
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40. The phase of sensorimotor mu and beta oscillations has the opposite effect on corticospinal excitability

Author

Miles Wischnewski, Zachary J. Haigh, Sina Shirinpour, Ivan Alekseichuk, and Alexander Opitz

Subjects
Transcranial magnetic stimulation, Electroencephalography, Neural oscillation phase, Real-time neuromodulation, Mu oscillations, Beta oscillations, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: Neural oscillations in the primary motor cortex (M1) shape corticospinal excitability. Power and phase of ongoing mu (8–13 Hz) and beta (14–30 Hz) activity may mediate motor cortical output. However, the functional dynamics of both mu and beta phase and power relationships and their interaction, are largely unknown. Objective: Here, we employ recently developed real-time targeting of the mu and beta rhythm, to apply phase-specific brain stimulation and probe motor corticospinal excitability non-invasively. For this, we used instantaneous read-out and analysis of ongoing oscillations, targeting four different phases (0°, 90°, 180°, and 270°) of mu and beta rhythms with suprathreshold single-pulse transcranial magnetic stimulation (TMS) to M1. Ensuing motor evoked potentials (MEPs) in the right first dorsal interossei muscle were recorded. Twenty healthy adults took part in this double-blind randomized crossover study. Results: Mixed model regression analyses showed significant phase-dependent modulation of corticospinal output by both mu and beta rhythm. Strikingly, these modulations exhibit a double dissociation. MEPs are larger at the mu trough and rising phase and smaller at the peak and falling phase. For the beta rhythm we found the opposite behavior. Also, mu power, but not beta power, was positively correlated with corticospinal output. Power and phase effects did not interact for either rhythm, suggesting independence between these aspects of oscillations. Conclusion: Our results provide insights into real-time motor cortical oscillation dynamics, which offers the opportunity to improve the effectiveness of TMS by specifically targeting different frequency bands.

Published
2022
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41. Unlocking environmental archives in the Arctic—insights from modern diatom-environment relationships in lakes and ponds across Greenland

Author

Kaarina Weckström, Jan Weckström, Juliane Wischnewski, Thomas A. Davidson, Torben L. Lauridsen, Frank Landkildehus, Kirsten S. Christoffersen, and Erik Jeppesen

Subjects
palaeolimnology, diatoms, diversity, dispersal, lakes and ponds, climate change, Evolution, QH359-425, Ecology, QH540-549.5
Abstract

Given the current rate of Arctic warming, the associated ecological changes need to be put into a longer-term context of natural variability. Palaeolimnology offers tools to explore archives stored in the sediments of Arctic lakes and ponds. The interpretation of these archives requires a sound knowledge of the ecology and distribution of the sedimentary proxy organisms used. Here we explored the relationship between diatoms, a widely used proxy group of siliceous algae, and the environmental drivers defining their assemblages and diversity in 115 lakes and ponds in Greenland, a markedly understudied arctic region covering extensive climate and environmental gradients. The main environmental drivers of diatom communities were related to climate and lake ontogeny, including both measured and unmeasured (spatially structured) environmental variables. The lakes and ponds in the northern study regions showed a distinctive dominance of small benthic fragilarioid species, while diatom communities in the South(west) of Greenland were more varied, including many epiphytes, owing to the longer growing season and higher habitat diversity of these lakes and ponds. The newly established lakes in the Ilulissat region host markedly different communities compared to all other sites. Species diversity followed an overall clear latitudinal decline towards the North. Despite the large distances between our study regions, diatom dispersal appeared not to be limited. Based on our results, diatoms are an excellent proxy for climate-mediated lake ecosystem change in the Arctic and thus a valuable tool for climate reconstructions in the region. Particular consideration should be given to often unmeasured climate-related drivers, such as in-lake habitat availability, due to their apparent importance in defining Arctic diatom communities.

Published
2023
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45. Science with the Cherenkov Telescope Array

Author

Consortium, The Cherenkov Telescope Array, Acharya, B. S., Agudo, I., Samarai, I. Al, Alfaro, R., Alfaro, J., Alispach, C., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrosi, G., Antolini, E., Antonelli, L. A., Aramo, C., Araya, M., Armstrong, T., Arqueros, F., Arrabito, L., Asano, K., Ashley, M., Backes, M., Balazs, C., Balbo, M., Ballester, O., Ballet, J., Bamba, A., Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Becherini, Y., Belfiore, A., Benbow, W., Berge, D., Bernardini, E., Bernardini, M. G., Bernardos, M., Bernlöhr, K., Bertucci, B., Biasuzzi, B., Bigongiari, C., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Boisson, C., Bolmont, J., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Bosnjak, Z., Böttcher, M., Braiding, C., Bregeon, J., Brill, A., Brown, A. M., Brun, P., Brunetti, G., Buanes, T., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Canestrari, R., Capalbi, M., Capitanio, F., Caproni, A., Caraveo, P., Cárdenas, V., Carlile, C., Carosi, R., Carquín, E., Carr, J., Casanova, S., Cascone, E., Catalani, F., Catalano, O., Cauz, D., Cerruti, M., Chadwick, P., Chaty, S., Chaves, R. C. G., Chen, A., Chen, X., Chernyakova, M., Chikawa, M., Christov, A., Chudoba, J., Cieślar, M., Coco, V., Colafrancesco, S., Colin, P., Conforti, V., Connaughton, V., Conrad, J., Contreras, J. L., Cortina, J., Costa, A., Costantini, H., Cotter, G., Covino, S., Crocker, R., Cuadra, J., Cuevas, O., Cumani, P., D'Aì, A., D'Ammando, F., D'Avanzo, P., D'Urso, D., Daniel, M., Davids, I., Dawson, B., Dazzi, F., De Angelis, A., Anjos, R. de Cássia dos, De Cesare, G., De Franco, A., Pino, E. M. de Gouveia Dal, de la Calle, I., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., De Lucia, M., de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., De Persio, F., de Souza, V., Deil, C., Del Santo, M., Delgado, C., della Volpe, D., Di Girolamo, T., Di Pierro, F., Di Venere, L., Díaz, C., Dib, C., Diebold, S., Djannati-Ataï, A., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Drass, H., Dravins, D., Dubus, G., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Ekoume, T. R. N., Elsässer, D., Ernenwein, J. -P., Espinoza, C., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Falcone, A., Farnier, C., Fasola, G., Fedorova, E., Fegan, S., Fernandez-Alonso, M., Fernández-Barral, A., Ferrand, G., Fesquet, M., Filipovic, M., Fioretti, V., Fontaine, G., Fornasa, M., Fortson, L., Coromina, L. Freixas, Fruck, C., Fujita, Y., Fukazawa, Y., Funk, S., Füßling, M., Gabici, S., Gadola, A., Gallant, Y., Garcia, B., López, R. Garcia, Garczarczyk, M., Gaskins, J., Gasparetto, T., Gaug, M., Gerard, L., Giavitto, G., Giglietto, N., Giommi, P., Giordano, F., Giro, E., Giroletti, M., Giuliani, A., Glicenstein, J. -F., Gnatyk, R., Godinovic, N., Goldoni, P., Gómez-Vargas, G., González, M. M., González, J. M., Götz, D., Graham, J., Grandi, P., Granot, J., Green, A. J., Greenshaw, T., Griffiths, S., Gunji, S., Hadasch, D., Hara, S., Hardcastle, M. J., Hassan, T., Hayashi, K., Hayashida, M., Heller, M., Helo, J. C., Hermann, G., Hinton, J., Hnatyk, B., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Horns, D., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Humensky, T. B., Hütten, M., Iarlori, M., Inada, T., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Iocco, F., Ioka, K., Iori, M., Ishio, K., Iwamura, Y., Jamrozy, M., Janecek, P., Jankowsky, D., Jean, P., Jung-Richardt, I., Jurysek, J., Kaaret, P., Karkar, S., Katagiri, H., Katz, U., Kawanaka, N., Kazanas, D., Khélifi, B., Kieda, D. B., Kimeswenger, S., Kimura, S., Kisaka, S., Knapp, J., Knödlseder, J., Koch, B., Kohri, K., Komin, N., Kosack, K., Kraus, M., Krause, M., Krauß, F., Kubo, H., Mezek, G. Kukec, Kuroda, H., Kushida, J., La Palombara, N., Lamanna, G., Lang, R. G., Lapington, J., Blanc, O. Le, Leach, S., Lees, J. -P., Lefaucheur, J., de Oliveira, M. A. Leigui, Lenain, J. -P., Lico, R., Limon, M., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., López, M., López-Coto, R., Lu, C. -C., Lucarelli, F., Luque-Escamilla, P. L., Lyard, E., Maccarone, M. C., Maier, G., Majumdar, P., Malaguti, G., Mandat, D., Maneva, G., Manganaro, M., Mangano, S., Marcowith, A., Marín, J., Markoff, S., Martí, J., Martin, P., Martínez, M., Martínez, G., Masetti, N., Masuda, S., Maurin, G., Maxted, N., Mazin, D., Medina, C., Melandri, A., Mereghetti, S., Meyer, M., Minaya, I. A., Mirabal, N., Mirzoyan, R., Mitchell, A., Mizuno, T., Moderski, R., Mohammed, M., Mohrmann, L., Montaruli, T., Moralejo, A., Morcuende-Parrilla, D., Mori, K., Morlino, G., Morris, P., Morselli, A., Moulin, E., Mukherjee, R., Mundell, C., Murach, T., Muraishi, H., Murase, K., Nagai, A., Nagataki, S., Nagayoshi, T., Naito, T., Nakamori, T., Nakamura, Y., Niemiec, J., Nieto, D., Nikołajuk, M., Nishijima, K., Noda, K., Nosek, D., Novosyadlyj, B., Nozaki, S., O'Brien, P., Oakes, L., Ohira, Y., Ohishi, M., Ohm, S., Okazaki, N., Okumura, A., Ong, R. A., Orienti, M., Orito, R., Osborne, J. P., Ostrowski, M., Otte, N., Oya, I., Padovani, M., Paizis, A., Palatiello, M., Palatka, M., Paoletti, R., Paredes, J. M., Pareschi, G., Parsons, R. D., Pe'er, A., Pech, M., Pedaletti, G., Perri, M., Persic, M., Petrashyk, A., Petrucci, P., Petruk, O., Peyaud, B., Pfeifer, M., Piano, G., Pisarski, A., Pita, S., Pohl, M., Polo, M., Pozo, D., Prandini, E., Prast, J., Principe, G., Prokhorov, D., Prokoph, H., Prouza, M., Pühlhofer, G., Punch, M., Pürckhauer, S., Queiroz, F., Quirrenbach, A., Rainò, S., Razzaque, S., Reimer, O., Reimer, A., Reisenegger, A., Renaud, M., Rezaeian, A. H., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Riquelme, M., Rivoire, S., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Rojas, G., Romano, P., Romeo, G., Rosado, J., Rovero, A. C., Rowell, G., Rudak, B., Rugliancich, A., Rulten, C., Sadeh, I., Safi-Harb, S., Saito, T., Sakaki, N., Sakurai, S., Salina, G., Sánchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Sarkar, S., Satalecka, K., Saturni, F. G., Schioppa, E. J., Schlenstedt, S., Schneider, M., Schoorlemmer, H., Schovanek, P., Schulz, A., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Seitenzahl, I., Semikoz, D., Sergijenko, O., Servillat, M., Shalchi, A., Shellard, R. C., Sidoli, L., Siejkowski, H., Sillanpää, A., Sironi, G., Sitarek, J., Sliusar, V., Slowikowska, A., Sol, H., Stamerra, A., Stanič, S., Starling, R., Stawarz, Ł., Stefanik, S., Stephan, M., Stolarczyk, T., Stratta, G., Straumann, U., Suomijarvi, T., Supanitsky, A. D., Tagliaferri, G., Tajima, H., Tavani, M., Tavecchio, F., Tavernet, J. -P., Tayabaly, K., Tejedor, L. A., Temnikov, P., Terada, Y., Terrier, R., Terzic, T., Teshima, M., Testa, V., Thoudam, S., Tian, W., Tibaldo, L., Tluczykont, M., Peixoto, C. J. Todero, Tokanai, F., Tomastik, J., Tonev, D., Tornikoski, M., Torres, D. F., Torresi, E., Tosti, G., Tothill, N., Tovmassian, G., Travnicek, P., Trichard, C., Trifoglio, M., Pujadas, I. Troyano, Tsujimoto, S., Umana, G., Vagelli, V., Vagnetti, F., Valentino, M., Vallania, P., Valore, L., van Eldik, C., Vandenbroucke, J., Varner, G. S., Vasileiadis, G., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Vega, A., Vercellone, S., Veres, P., Vergani, S., Verzi, V., Vettolani, G. P., Viana, A., Vigorito, C., Villanueva, J., Voelk, H., Vollhardt, A., Vorobiov, S., Vrastil, M., Vuillaume, T., Wagner, S. J., Wagner, R., Walter, R., Ward, J. E., Warren, D., Watson, J. J., Werner, F., White, M., White, R., Wierzcholska, A., Wilcox, P., Will, M., Williams, D. A., Wischnewski, R., Wood, M., Yamamoto, T., Yamazaki, R., Yanagita, S., Yang, L., Yoshida, T., Yoshiike, S., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zampieri, L., Zandanel, F., Zanin, R., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., Ziegler, A., and Zorn, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

The Cherenkov Telescope Array, CTA, will be the major global observatory for very high energy gamma-ray astronomy over the next decade and beyond. The scientific potential of CTA is extremely broad: from understanding the role of relativistic cosmic particles to the search for dark matter. CTA is an explorer of the extreme universe, probing environments from the immediate neighbourhood of black holes to cosmic voids on the largest scales. Covering a huge range in photon energy from 20 GeV to 300 TeV, CTA will improve on all aspects of performance with respect to current instruments. The observatory will operate arrays on sites in both hemispheres to provide full sky coverage and will hence maximize the potential for the rarest phenomena such as very nearby supernovae, gamma-ray bursts or gravitational wave transients. With 99 telescopes on the southern site and 19 telescopes on the northern site, flexible operation will be possible, with sub-arrays available for specific tasks. CTA will have important synergies with many of the new generation of major astronomical and astroparticle observatories. Multi-wavelength and multi-messenger approaches combining CTA data with those from other instruments will lead to a deeper understanding of the broad-band non-thermal properties of target sources. The CTA Observatory will be operated as an open, proposal-driven observatory, with all data available on a public archive after a pre-defined proprietary period. Scientists from institutions worldwide have combined together to form the CTA Consortium. This Consortium has prepared a proposal for a Core Programme of highly motivated observations. The programme, encompassing approximately 40% of the available observing time over the first ten years of CTA operation, is made up of individual Key Science Projects (KSPs), which are presented in this document., Comment: 213 pages, including references and glossary. Version 2: credits and references updated, some figures updated, and author list updated

Published
2017
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46. Prospects for CTA observations of the young SNR RX J1713.7-3946

Author

Consortium, The CTA, Acero, F., Aloisio, R., Amans, J., Amato, E., Antonelli, L. A., Aramo, C., Armstrong, T., Arqueros, F., Asano, K., Ashley, M., Backes, M., Balazs, C., Balzer, A., Bamba, A., Barkov, M., Barrio, J. A., Benbow, W., Bernlöhr, K., Beshley, V., Bigongiari, C., Biland, A., Bilinsky, A., Bissaldi, E., Biteau, J., Blanch, O., Blasi, P., Blazek, J., Boisson, C., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Braiding, C., Brau-Nogué, S., Bregeon, J., Brown, A. M., Bugaev, V., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Böttcher, M., Cameron, R., Capalbi, M., Caproni, A., Caraveo, P., Carosi, R., Cascone, E., Cerruti, M., Chaty, S., Chen, A., Chen, X., Chernyakova, M., Chikawa, M., Chudoba, J., Cohen-Tanugi, J., Colafrancesco, S., Conforti, V., Contreras, J. L., Costa, A., Cotter, G., Covino, S., Covone, G., Cumani, P., Cusumano, G., D'Ammando, F., D'Urso, D., Daniel, M., Dazzi, F., De Angelis, A., De Cesare, G., De Franco, A., De Frondat, F., Pino, E. M. de Gouveia Dal, De Lisio, C., Lopez, R. de los Reyes, De Lotto, B., de Naurois, M., De Palma, F., Del Santo, M., Delgado, C., della Volpe, D., Di Girolamo, T., Di Giulio, C., Di Pierro, F., Di Venere, L., Doro, M., Dournaux, J., Dumas, D., Dwarkadas, V., Díaz, C., Ebr, J., Egberts, K., Einecke, S., Elsässer, D., Eschbach, S., Falceta-Goncalves, D., Fasola, G., Fedorova, E., Fernández-Barral, A., Ferrand, G., Fesquet, M., Fiandrini, E., Fiasson, A., Filipovíc, M. D., Fioretti, V., Font, L., Fontaine, G., Franco, F. J., Coromina, L. Freixas, Fujita, Y., Fukui, Y., Funk, S., Förster, A., Gadola, A., López, R. Garcia, Garczarczyk, M., Giglietto, N., Giordano, F., Giuliani, A., Glicenstein, J., Gnatyk, R., Goldoni, P., Grabarczyk, T., Graciani, R., Graham, J., Grandi, P., Granot, J., Green, A. J., Griffiths, S., Gunji, S., Hakobyan, H., Hara, S., Hassan, T., Hayashida, M., Heller, M., Helo, J. C., Hinton, J., Hnatyk, B., Huet, J., Huetten, M., Humensky, T. B., Hussein, M., Hörandel, J., Ikeno, Y., Inada, T., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Ioka, K., Iori, M., Jacquemier, J., Janecek, P., Jankowsky, D., Jung, I., Kaaret, P., Katagiri, H., Kimeswenger, S., Kimura, S., Knödlseder, J., Koch, B., Kocot, J., Kohri, K., Komin, N., Konno, Y., Kosack, K., Koyama, S., Kraus, M., Kubo, H., Mezek, G. Kukec, Kushida, J., La Palombara, N., Lalik, K., Lamanna, G., Landt, H., Lapington, J., Laporte, P., Lee, S., Lees, J., Lefaucheur, J., Lenain, J. -P., Leto, G., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., Lopez, M., Lucarelli, F., Luque-Escamilla, P. L., López-Coto, R., Maccarone, M. C., Maier, G., Malaguti, G., Mandat, D., Maneva, G., Mangano, S., Marcowith, A., Martí, J., Martínez, M., Martínez, G., Masuda, S., Maurin, G., Maxted, N., Melioli, C., Mineo, T., Mirabal, N., Mizuno, T., Moderski, R., Mohammed, M., Montaruli, T., Moralejo, A., Mori, K., Morlino, G., Morselli, A., Moulin, E., Mukherjee, R., Mundell, C., Muraishi, H., Murase, K., Nagataki, S., Nagayoshi, T., Naito, T., Nakajima, D., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nievas-Rosillo, M., Nikołajuk, M., Nishijima, K., Noda, K., Nogues, L., Nosek, D., Novosyadlyj, B., Nozaki, S., Ohira, Y., Ohishi, M., Ohm, S., Okumura, A., Ong, R. A., Orito, R., Orlati, A., Ostrowski, M., Oya, I., Padovani, M., Palacio, J., Palatka, M., Paredes, J. M., Pavy, S., Pe'er, A., Persic, M., Petrucci, P., Petruk, O., Pisarski, A., Pohl, M., Porcelli, A., Prandini, E., Prast, J., Principe, G., Prouza, M., Pueschel, E., Pühlhofer, G., Quirrenbach, A., Rameez, M., Reimer, O., Renaud, M., Ribó, M., Rico, J., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Romano, P., Romeo, G., Rosado, J., Rousselle, J., Rowell, G., Rudak, B., Sadeh, I., Safi-Harb, S., Saito, T., Sakaki, N., Sanchez, D., Sangiorgi, P., Sano, H., Santander, M., Sarkar, S., Sawada, M., Schioppa, E. J., Schoorlemmer, H., Schovanek, P., Schussler, F., Sergijenko, O., Servillat, M., Shalchi, A., Shellard, R. C., Siejkowski, H., Sillanpää, A., Simone, D., Sliusar, V., Sol, H., Stanič, S., Starling, R., Stawarz, Ł., Stefanik, S., Stephan, M., Stolarczyk, T., Szanecki, M., Szepieniec, T., Tagliaferri, G., Tajima, H., Takahashi, M., Takeda, J., Tanaka, M., Tanaka, S., Tejedor, L. A., Telezhinsky, I., Temnikov, P., Terada, Y., Tescaro, D., Teshima, M., Testa, V., Thoudam, S., Tokanai, F., Torres, D. F., Torresi, E., Tosti, G., Townsley, C., Travnicek, P., Trichard, C., Trifoglio, M., Tsujimoto, S., Vagelli, V., Vallania, P., Valore, L., van Driel, W., van Eldik, C., Vandenbroucke, J., Vassiliev, V., Vecchi, M., Vercellone, S., Vergani, S., Vigorito, C., Vorobiov, S., Vrastil, M., Acosta, M. L. Vázquez, Wagner, S. J., Wagner, R., Wakely, S. P., Walter, R., Ward, J. E., Watson, J. J., Weinstein, A., White, M., White, R., Wierzcholska, A., Wilcox, P., Williams, D. A., Wischnewski, R., Wojcik, P., Yamamoto, T., Yamamoto, H., Yamazaki, R., Yanagita, S., Yang, L., Yoshida, T., Yoshida, M., Yoshiike, S., Yoshikoshi, T., Zacharias, M., Zampieri, L., Zanin, R., Zavrtanik, M., Zavrtanik, D., Zdziarski, A., Zech, A., Zechlin, H., Zhdanov, V., Ziegler, A., and Zorn, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We perform simulations for future Cherenkov Telescope Array (CTA) observations of RX~J1713.7$-$3946, a young supernova remnant (SNR) and one of the brightest sources ever discovered in very-high-energy (VHE) gamma rays. Special attention is paid to explore possible spatial (anti-)correlations of gamma rays with emission at other wavelengths, in particular X-rays and CO/H{\sc i} emission. We present a series of simulated images of RX J1713.7$-$3946 for CTA based on a set of observationally motivated models for the gamma-ray emission. In these models, VHE gamma rays produced by high-energy electrons are assumed to trace the non-thermal X-ray emission observed by {\it XMM-Newton}, whereas those originating from relativistic protons delineate the local gas distributions. The local atomic and molecular gas distributions are deduced by the NANTEN team from CO and H{\sc i} observations. Our primary goal is to show how one can distinguish the emission mechanism(s) of the gamma rays (i.e., hadronic vs leptonic, or a mixture of the two) through information provided by their spatial distribution, spectra, and time variation. This work is the first attempt to quantitatively evaluate the capabilities of CTA to achieve various proposed scientific goals by observing this important cosmic particle accelerator., Comment: 19 pages, 5 figures. Accepted for publication in ApJ

Published
2017
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