482 results on '"Wiseman, R. Luke"'
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2. ATF6 protects against protein misfolding during cardiac hypertrophy
3. Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity
4. Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells
5. Mitochondria and Endoplasmic Reticulum Stress in Retinal Organoids from Patients with Vision Loss
6. PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid
7. Multiexon deletion alleles of ATF6 linked to achromatopsia
8. Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis
9. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein
10. ATF6 is essential for human cone photoreceptor development
11. Reshaping endoplasmic reticulum quality control through the unfolded protein response
12. Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements
13. The unfolded protein response regulator ATF6 promotes mesodermal differentiation
14. Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors
15. Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity
16. eLife assessment: Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans
17. Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
18. Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion
19. Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
20. Mapping Stress-Responsive Signaling Pathways Induced by Mitochondrial Proteostasis Perturbations
21. Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B
22. Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly
23. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
24. Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates
25. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
26. Structures of the human LONP1 protease reveal regulatory steps involved in protease activation
27. Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease
28. Proteostasis and Beyond: ATF6 in Ischemic Disease
29. eLife assessment: Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress
30. eLife assessment: Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress
31. Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation
32. The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome
33. Chapter Three - Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases
34. Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
35. Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing
36. Succinylation of a KEAP1 sensor lysine promotes NRF2 activation
37. Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators
38. Quantifying organellar ultrastructure in cryo-electron tomography using a surface morphometrics pipeline
39. Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics
40. Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy
41. Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly
42. S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling
43. PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress
44. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
45. Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases
46. Lining up for quality control: linear ubiquitin and proteotoxicity
47. Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells
48. Quantifying organellar ultrastructure in cryo-electron tomography using a surface morphometrics pipeline
49. Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators
50. Optimization of 3-Aminotetrahydrothiophene 1,1-Dioxides with Improved Potency and Efficacy as Non-Electrophilic Antioxidant Response Element (ARE) Activators
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