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5. Combined analysis of gut microbiota, diet and PNPLA3 polymorphism in biopsy‐proven non‐alcoholic fatty liver disease

Author

Lang, Sonja, Martin, Anna, Zhang, Xinlian, Farowski, Fedja, Wisplinghoff, Hilmar, Vehreschild, Maria JGT, Krawczyk, Marcin, Nowag, Angela, Kretzschmar, Anne, Scholz, Claus, Kasper, Philipp, Roderburg, Christoph, Mohr, Raphael, Lammert, Frank, Tacke, Frank, Schnabl, Bernd, Goeser, Tobias, Steffen, Hans‐Michael, and Demir, Münevver

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Liver Disease and Cirrhosis, Liver Disease, Nutrition, Digestive Diseases, Prevention, Genetics, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Inflammatory and immune system, Oral and gastrointestinal, Good Health and Well Being, Aged, Biopsy, Cross-Sectional Studies, Diet, Gastrointestinal Microbiome, Humans, Lipase, Liver, Membrane Proteins, Non-alcoholic Fatty Liver Disease, Polymorphism, Single Nucleotide, microbiome, microbiota, NAFLD, NASH, nutrition, PNPLA3, PNPLA3, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background and aimsNon-alcoholic fatty liver disease (NAFLD) is a global health burden. Risk factors for disease severity include older age, increased body mass index (BMI), diabetes, genetic variants, dietary factors and gut microbiota alterations. However, the interdependence of these factors and their individual impact on disease severity remain unknown.MethodsIn this cross-sectional study, we performed 16S gene sequencing using fecal samples, collected dietary intake, PNPLA3 gene variants and clinical and liver histology parameters in a well-described cohort of 180 NAFLD patients. Principal component analyses were used for dimensionality reduction of dietary and microbiota data. Simple and multiple stepwise ordinal regression analyses were performed.ResultsComplete data were available for 57 NAFLD patients. In the simple regression analysis, features associated with the metabolic syndrome had the highest importance regarding liver disease severity. In the multiple regression analysis, BMI was the most important factor associated with the fibrosis stage (OR per kg/m2 : 1.23, 95% CI 1.10-1.37, P

Published
2021

6. Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease

Author

Lang, Sonja, Demir, Münevver, Martin, Anna, Jiang, Lu, Zhang, Xinlian, Duan, Yi, Gao, Bei, Wisplinghoff, Hilmar, Kasper, Philipp, Roderburg, Christoph, Tacke, Frank, Steffen, Hans-Michael, Goeser, Tobias, Abraldes, Juan G, Tu, Xin M, Loomba, Rohit, Stärkel, Peter, Pride, David, Fouts, Derrick E, and Schnabl, Bernd

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition and Dietetics, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Clinical Research, Liver Disease, Oral and gastrointestinal, Infection, Adult, Aged, Case-Control Studies, Cross-Sectional Studies, Feces, Female, Gastrointestinal Microbiome, Humans, Intestines, Liver Cirrhosis, Male, Middle Aged, Non-alcoholic Fatty Liver Disease, Prospective Studies, Severity of Illness Index, Virome, Young Adult, Microbiota, Biomarker, Prognostic Factor, Progression, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsAlterations in the gut microbiome have been associated with the severity of nonalcoholic fatty liver disease (NAFLD). Previous studies focused exclusively on the bacteria in the microbiome; we investigated changes in the viral microbiome (virome) in patients with NAFLD.MethodsIn a prospective, cross-sectional, observational study, we extracted RNA and DNA virus-like particles from fecal samples from 73 patients with NAFLD: 29 patients had an NAFLD Activity Score (NAS) of 0-4, 44 patients had an NAS of 5-8 or liver cirrhosis (LCI), 37 patients had F0-F1 fibrosis, and 36 patients had F2-F4 fibrosis. As controls, 9 individuals without liver disease and 13 patients with mild primary biliary cholangitis were included in the analysis. We performed shotgun metagenomic sequencing of virus-like particles.ResultsPatients with NAFLD and NAS 5-8/LCI had a significant decrease in intestinal viral diversity compared with patients with NAFLD and NAS 0-4 or control individuals. The presence of more advanced NAFLD was associated with a significant reduction in the proportion of bacteriophages compared with other intestinal viruses. Using multivariate logistic regression analysis with leave-1-out cross validation, we developed a model, including a viral diversity index and simple clinical variables, that identified patients with NAS 5-8/LCI with an area under the curve of 0.95 (95% confidence interval, 0.91-0.99) and F2-F4 fibrosis with an area under the curve of 0.88 (95% confidence interval, 0.80-0.95). Addition of data on viral diversity significantly improved multivariate models, including those based on only clinical parameters or bacterial diversity.ConclusionsIn a study of fecal viromes from patients with NAFLD and control individuals, we associated histologic markers of NAFLD severity with significant decreases in viral diversity and proportion of bacteriophages. We developed a model based on fecal viral diversity and clinical data that identifies patients with severe NAFLD and fibrosis more accurately than models based only on clinical or bacterial data.

Published
2020

9. Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children

Author

Dewald, Felix, Suárez, Isabelle, Johnen, Ronja, Grossbach, Jan, Moran-Tovar, Roberto, Steger, Gertrud, Joachim, Alexander, Rubio, Gibran Horemheb, Fries, Mira, Behr, Florian, Kley, Joao, Lingnau, Andreas, Kretschmer, Alina, Gude, Carina, Baeza-Flores, Guadelupe, del Valle, David Laveaga, Roblero-Hernandez, Alberto, Magana-Cerino, Jesus, Hernandez, Adriana Torres, Ruiz-Quinones, Jesus, Schega, Konstantin, Linne, Viktoria, Junker, Lena, Wunsch, Marie, Heger, Eva, Knops, Elena, Di Cristanziano, Veronica, Meyer, Meike, Hünseler, Christoph, Weber, Lutz T., Lüers, Jan-Christoffer, Quade, Gustav, Wisplinghoff, Hilmar, Tiemann, Carsten, Zotz, Rainer, Jomaa, Hassan, Pranada, Arthur, Herzum, Ileana, Cullen, Paul, Schmitz, Franz-Josef, Philipsen, Paul, Kirchner, Georg, Knabbe, Cornelius, Hellmich, Martin, Buess, Michael, Wolff, Anna, Kossow, Annelene, Niessen, Johannes, Jeworutzki, Sebastian, Schräpler, Jörg-Peter, Lässig, Michael, Dötsch, Jörg, Fätkenheuer, Gerd, Kaiser, Rolf, Beyer, Andreas, Rybniker, Jan, and Klein, Florian

Published
2022
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10. Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis

Author

Schwarz, Carsten, Eschenhagen, Patience, Schmid, Henrijette, Hohnstein, Thordis, Grehn, Claudia, Iwert, Christina, Roehmel, Jobst, Steinke, Eva, Stahl, Mirjam, Lozza, Laura, Tikhonova, Ekaterina, Rosati, Elisa, Stervbo, Ulrik, Babel, Nina, Mainz, Jochen G., Wisplinghoff, Hilmar, Ebel, Frank, Jia, Lei-Jie, Blango, Matthew G., Hortschansky, Peter, Brunke, Sascha, Hube, Bernhard, Brakhage, Axel A., Kniemeyer, Olaf, Scheffold, Alexander, and Bacher, Petra

Subjects
Cross reactions (Immunology) -- Health aspects, Cystic fibrosis -- Physiological aspects, Immune response -- Health aspects, CD4 lymphocytes -- Physiological aspects -- Health aspects, Aspergillosis -- Physiological aspects -- Risk factors, Health care industry
Abstract

BACKGROUND. The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types of A. fumigatus-specific Th cells in pwCF and their contribution to protective immunity or inflammation remain poorly characterized. METHODS. We used antigen-reactive T cell enrichment (ARTE) to investigate fungus-reactive Th cells in peripheral blood of pwCF and healthy controls. RESULTS. We show that clonally expanded, high-avidity A. fumigatus-specific effector Th cells, which were absent in healthy donors, developed in pwCF. Individual patients were characterized by distinct Th1-, Th2-, or Th17- dominated responses that remained stable over several years. These different Th subsets target different A. fumigatus proteins, indicating that differential antigen uptake and presentation directs Th cell subset development. Patients with allergic bronchopulmonary aspergillosis (ABPA) are characterized by high frequencies of Th2 cells that cross- recognize various filamentous fungi. CONCLUSION. Our data highlight the development of heterogenous Th responses targeting different protein fractions of a single fungal pathogen and identify the development of multispecies cross- reactive Th2 cells as a potential risk factor for ABPA. FUNDING. German Research Foundation (DFG), under Germany's Excellence Strategy (EXC 2167-390884018 'Precision Medicine in Chronic Inflammation' and EXC 2051-390713860 'Balance of the Microverse'); Oskar Helene Heim Stiftung; Christiane Herzog Stiftung; Mukoviszidose Institut gGmb; German Cystic Fibrosis Association Mukoviszidose e.V; German Federal Ministry of Education and Science (BMBF) InfectControl 2020 Projects AnDiPath (BMBF 03ZZ0838A+B)., Introduction Humans are constantly exposed to ubiquitous airborne fungi such as Aspergillus fumigatus. Despite this continuous challenge, healthy individuals rarely develop Aspergillus-associated diseases. This is likely due to rapid clearing [...]

Published
2023
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11. Invasive Scedosporium spp. and Lomentospora prolificans infections in pediatric patients: Analysis of 55 cases from FungiScope® and the literature

Author

Seidel, Danila, Hassler, Angela, Salmanton-García, Jon, Koehler, Philipp, Mellinghoff, Sibylle C., Carlesse, Fabianne, Cheng, Matthew P., Falces-Romero, Iker, Herbrecht, Raoul, Jover Sáenz, Alfredo, Klimko, Nikolai, Mareş, Mihai, Lass-Flörl, Cornelia, Soler-Palacín, Pere, Wisplinghoff, Hilmar, Cornely, Oliver A., Pana, Zoi, and Lehrnbecher, Thomas

Published
2020
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17. Dietary omega-6/omega-3 ratio is not associated with gut microbiota composition and disease severity in patients with nonalcoholic fatty liver disease

Author

Heinzer, Kathrin, primary, Lang, Sonja, additional, Farowski, Fedja, additional, Wisplinghoff, Hilmar, additional, Vehreschild, Maria J.G.T., additional, Martin, Anna, additional, Nowag, Angela, additional, Kretzschmar, Anne, additional, Scholz, Claus Jürgen, additional, Roderburg, Christoph, additional, Mohr, Raphael, additional, Tacke, Frank, additional, Kasper, Philipp, additional, Goeser, Tobias, additional, Steffen, Hans-Michael, additional, and Demir, Münevver, additional

Published
2022
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19. Invasive Trichoderma spp. infections: clinical presentation and outcome of cases from the literature and the FungiScope® registry

Author

Sal, Ertan, primary, Stemler, Jannik, additional, Salmanton-García, Jon, additional, Falces-Romero, Iker, additional, Kredics, László, additional, Meyer, Elisabeth, additional, Würstl, Benjamin, additional, Lass-Flörl, Cornelia, additional, Racil, Zdenek, additional, Klimko, Nikolay, additional, Cesaro, Simone, additional, Kindo, Anupma Jyoti, additional, Wisplinghoff, Hilmar, additional, Koehler, Philipp, additional, Cornely, Oliver A, additional, and Seidel, Danila, additional

Published
2022
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26. List of Contributors

Author

Abrahamian, Fredrick M., primary, Aldape, Michael J., additional, Aldasoro, Edelweiss, additional, Allen, Upton D., additional, Al-Sum, Hythem, additional, Anadkat, Milan J., additional, Anders, Katherine, additional, Angelakis, Emmanouil, additional, Angus, Brian John, additional, Antoniadou, Anastasia, additional, Arena, Fabio, additional, Arends, Joop E., additional, Arribas, Jose R., additional, Artenstein, Andrew W., additional, Atherton, John C., additional, Aucott, John N., additional, Aw, Tar-Ching, additional, Babcock, Hilary M., additional, Bailey, Robin, additional, Bailey, Thomas C., additional, Banks, Adam Z., additional, Barillo, David J., additional, Barrette, Ernie-Paul, additional, Bauer, Martijn P., additional, Bayston, Roger, additional, Beard, C. Ben, additional, Beardsley, Justin, additional, Beeching, Nick J., additional, Bégué, Rodolfo E., additional, Beldi, Guido, additional, Benson, Constance A., additional, Berbari, Elie F., additional, Berenger, Jean-Michel, additional, Berger, Christoph, additional, Bernardino, Jose I., additional, Bille, Jacques, additional, Billioux, Alexander C., additional, Bitnun, Ari, additional, Blair, Iain, additional, Blanche, Stéphane, additional, Bleck, Thomas P., additional, Bleeker-Rovers, Chantal P., additional, Bleijenberg, Gijs, additional, Bloch, Karen C., additional, Blum, Johannes, additional, Blumberg, Emily A., additional, Bonomo, Robert A., additional, Bonten, Marc J.M., additional, Bourayou, Rafik, additional, Bouza, Emilio, additional, Brandt, K. Ashley, additional, Bretelle, Florence, additional, Brisse, Sylvain, additional, Britton, Warwick J., additional, Brook, Itzhak, additional, Brouwer, Matthijs C., additional, Browne, Sarah K., additional, Bryant, Amy E., additional, Bühler, Silja, additional, Bulger, Eileen M., additional, Buller, R. Mark L., additional, Burke, Leah A., additional, Burri, Christian, additional, Butler, Marcus W., additional, Calandra, Thierry, additional, Calfee, David P., additional, Calvo-Cano, Antonia, additional, Cameron, D. William, additional, Carcillo, Joseph A., additional, Carson, Gail, additional, Chambers, Stephen T., additional, Charrel, Remi N., additional, Nguyen, Vinh Chau Van, additional, Chevaliez, Stéphane, additional, Chiller, Tom M., additional, Christaki, Eirini, additional, Chung, Kevin K., additional, Clifford, David B., additional, Clumeck, Nathan, additional, Cohen, Jonathan, additional, Collinge, John, additional, Conlon, Christopher P., additional, Conrad, Curdin, additional, Cooke, Fiona J., additional, Cope, Jennifer Rittenhouse, additional, Corey, G. Ralph, additional, Cross, John H., additional, Cunha, Burke A., additional, Cunha, Cheston B., additional, D'Journo, Benoit, additional, Daikos, George L., additional, Daniels, Johannes M.A., additional, Davidson, Robert N., additional, Day, Nicholas P.J., additional, De Cock, Kevin M., additional, de Silva, Thushan I., additional, de Vries, Henry J.C., additional, de Wit, Stéphane, additional, Delaloye, Julie, additional, Denning, David W., additional, Dennis, David T., additional, Dhanireddy, Shireesha, additional, Dielubanza, Elodi J., additional, Diemert, David J., additional, Doganay, Mehmet, additional, Doherty, Tom, additional, Dolecek, Christiane, additional, Dondorp, Arjen M., additional, Douglas, Abby, additional, Drancourt, Michel, additional, Dubourg, Grégory, additional, Dudley, Michael N., additional, Durand, Guillaume, additional, Eckhardt, Benjamin J., additional, Efstratiou, Androulla, additional, Ekkelenkamp, Miquel B., additional, Eranki, Ambika, additional, Erdem, Hakan, additional, Escota, Gerome V., additional, Evans, Heather L., additional, Eziefula, Alice Chijioke, additional, Fenollar, Florence, additional, Fenwick, Alan, additional, Fierer, Joshua, additional, Finch, Roger G., additional, Fleckenstein, James M., additional, Forstner, Christina, additional, Foschi, Federico, additional, Fournier, Pierre-Edouard, additional, French, Martyn A., additional, Gage, Kenneth L., additional, Garcia, Lynne S., additional, Gascon, Joaquim, additional, Gastañaduy, Arturo S., additional, Gautret, Philippe, additional, Geisler, William M., additional, Ghanem, Khalil G., additional, Giani, Tommaso, additional, Giannella, Maddalena, additional, Gilliam, Bruce L., additional, Gilliet, Michel, additional, Glaser, Carol A., additional, Glupczynski, Youri, additional, Gnann, John W., additional, Goldstein, Ellie J.C., additional, Gottstein, Bruno, additional, Gouriet, Frederique, additional, Gravitt, Patti E., additional, Green, Michael D., additional, Green, Stephen T., additional, Groll, Andreas H., additional, Gulick, Roy M., additional, Gupta, Arjun, additional, Habib, Gilbert, additional, Harbarth, Stephan, additional, Harris, Marianne, additional, Hayden, Frederick G., additional, Hetem, David J., additional, Hill, Philip C., additional, Hirschel, Bernard, additional, Hodowanec, Aimee C., additional, Hoffart, Louis, additional, Hoffmann, Christian, additional, Holland, Steven M., additional, Horby, Peter W., additional, Horne, David J., additional, Hraiech, Sami, additional, Hull, Mark W., additional, Huttner, Angela, additional, Ingram, Richard J.M., additional, Islam, Jasmin, additional, Ison, Michael G., additional, James, Scott H., additional, Jenkins, Claire, additional, Jenkins, Stephen G., additional, Jensen, Jørgen Skov, additional, Johnston, Christine, additional, Jones, Theodore B., additional, Jordan, Stephen J., additional, Julian, Kathleen G., additional, Kato, Yasuyuki, additional, Kauffman, Carol A., additional, Kaye, Keith S., additional, Keane, Michael P., additional, Keeney, James, additional, Kelly, Paul, additional, Kent, Stephen J., additional, Kern, Winfried V., additional, Keynan, Yoav, additional, Kim, Andrea A., additional, Koné-Paut, Isabelle, additional, Kosmidis, Chris, additional, Kroes, Aloys C.M., additional, Kroon, Frank P., additional, Ksiazek, Thomas G., additional, Kuhlmann, F. Matthew, additional, Kuijper, Ed J., additional, Kwon, Jennie H., additional, Kyei, George B., additional, Lacombe, Karine, additional, Lagacé-Wiens, Philippe, additional, Lagier, Jean-Christophe, additional, Lamagni, Theresa, additional, Landraud, Luce, additional, Lanternier, Fanny, additional, LaPlante, Kerry L., additional, Lawn, Stephen D., additional, Lawrence, Steven J., additional, Leblebicioglu, Hakan, additional, Lee, Nelson, additional, Leggett, James E., additional, Lehours, Philippe, additional, Levy, Pierre-Yves, additional, Leyh, Rainer G., additional, Lillis, Rebecca A., additional, Limmathurotsakul, Direk, additional, Lin, Jennifer, additional, Lindquist, H.D. Alan, additional, Lipsky, Benjamin A., additional, Liscynesky, Christina, additional, Looney, David, additional, Lortholary, Olivier, additional, Lowy, Franklin D., additional, Luft, Benjamin J., additional, Mackowiak, Philip A., additional, MacPherson, Paul A., additional, Maghraoui-Slim, Valérie, additional, Mallon, Patrick W., additional, Mangino, Julie E., additional, Manuel, Oriol, additional, Marchetti, Oscar, additional, Marks, Kristen M., additional, Marr, Kieren A., additional, Marrazzo, Jeanne, additional, Marschall, Jonas, additional, Martin, David H., additional, Matonti, Frédéric, additional, Matulewicz, Richard S., additional, Mayer, Kenneth H., additional, McCulloh, Russell J., additional, McGready, Rose, additional, Mdodo, Rennatus, additional, Mead, Simon, additional, Mégraud, Francis, additional, Meintjes, Graeme, additional, Metcalf, Sarah C., additional, Michaels, Marian G., additional, Migliori, Giovanni Battista, additional, Miles, Michael A., additional, Miller, Alastair, additional, Mimiaga, Matthew J., additional, Mingeot-Leclercq, Marie-Paule, additional, Misch, Elizabeth Ann, additional, Mitreva, Makedonka, additional, Montaner, Julio S.G., additional, Moore, Caroline B., additional, Muñoz, Patricia, additional, Muñoz, Jose, additional, Murray, Clinton K., additional, Musso, Didier, additional, Mutengo, Mable, additional, Mutizwa, Misha M., additional, Naber, Kurt G., additional, Natarajan, Pavithra, additional, Neme, Santiago, additional, Newton, Paul N., additional, Nichols, Ronald A., additional, Nicolle, Lindsay E., additional, Nosten, François, additional, Notarangelo, Luigi D., additional, Nutman, Thomas B., additional, Nyirjesy, Paul, additional, O'Connell, P. Ronan, additional, Opal, Steven M., additional, Ormerod, L. Peter, additional, Osmon, Douglas R., additional, Pankert, Marie Boulze, additional, Pantaleo, Giuseppe, additional, Papazian, Laurent, additional, Parente, Diane M., additional, Parola, Philippe, additional, Parsaei, Shadi, additional, Pascual, Manuel A., additional, Patel, Rupa, additional, Patrozou, Eleni, additional, Pawlotsky, Jean-Michel, additional, Peacock, Sharon J., additional, Pechère, Jean-Claude, additional, Pelegrin, Ivan, additional, Peters, Barry S., additional, Peters, Edgar J.G., additional, Petersen, Jeannine M., additional, Petersen, Lyle R., additional, Petraitis, Vidmantas, additional, Pham, Luu-Ly, additional, Picado, Albert, additional, Pilatz, Adrian, additional, Pilmis, Benoit, additional, Pinazo, María-Jesús, additional, Pletz, Mathias W., additional, Pogue, Jason M., additional, Polgreen, Evelyn L., additional, Polgreen, Philip M., additional, Posfay-Barbe, Klara M., additional, Powderly, William G., additional, Presti, Rachel, additional, Prod'hom, Guy, additional, Puolakkainen, Mirja, additional, Quinn, Thomas C., additional, Raoult, Didier, additional, Razonable, Raymund R., additional, Read, Robert C., additional, Redfield, Robert R., additional, Rentenaar, Rob J., additional, Reynolds, Steven J., additional, Ribi, Camillo, additional, Richardson, Malcolm D., additional, Ritter, Michele L., additional, Roch, Antoine, additional, Rockstroh, Jürgen Kurt, additional, Rojek, Amanda, additional, Romero, José R., additional, Rooijakkers, Suzan H.M., additional, Rosenbluth, Daniel, additional, Rosenzweig, Sergio D., additional, Rossolini, Gian Maria, additional, Rubinstein, Ethan, additional, Ryan, Greg, additional, Safren, Steven A., additional, Sahasrabuddhe, Vikrant V., additional, Saikku, Pekka A.I., additional, Sajadi, Mohammad M., additional, Salvaggio, Michelle R., additional, Santos, Carlos A.Q., additional, Satlin, Michael J., additional, Schaeffer, Anthony J., additional, Schimmer, Christoph, additional, Schooley, Robert T., additional, Schumacher, Richard F., additional, Sha, Beverly E., additional, Shapiro, Daniel S., additional, Sheehan, Gerard, additional, Shlaes, David M., additional, Shoham, Shmuel, additional, Simmons, Cameron P., additional, Simon, Dennis W., additional, Simon, Matthew S., additional, Simonsen, Kari A., additional, Slack, Mary P.E., additional, Smith, Tyrel T., additional, Sobel, Jack D., additional, Souli, Maria, additional, Sridhar, Shruti, additional, Steckelberg, James M., additional, Stevens, Dennis L., additional, Strah, Heather, additional, Sturm, A. Willem, additional, Sungkanuparph, Somnuek, additional, Tabrizi, Sarah J., additional, Tacconelli, Evelina, additional, Tan, Chen Sabrina, additional, Taplitz, Randy A., additional, Thomas, Guillemette, additional, Thomas, Lora D., additional, Thuny, Franck, additional, Thwaites, Guy, additional, Tissot, Frederic, additional, Tønjum, Tone, additional, Torriani, Francesca J., additional, Toso, Christian, additional, Tulkens, Paul M., additional, Tunkel, Allan R., additional, Turner, Claire E., additional, Ustianowski, Andrew P., additional, van Bambeke, Françoise, additional, van Crevel, Reinout, additional, van de Beek, Diederik, additional, van Delden, Christian, additional, van der Eerden, Menno M., additional, van der Meer, Jos W.M., additional, van der Poll, Tom, additional, van Ingen, Jakko, additional, van Putten, Jos, additional, Vaudaux, Bernard P., additional, Vermund, Sten H., additional, Viscidi, Raphael P., additional, Visvanathan, Kumar, additional, Visvesvara, Govinda S., additional, von Seidlein, Lorenz, additional, Wagenlehner, Florian M.E., additional, Wald, Anna, additional, Walsh, Thomas J., additional, Warhurst, David C., additional, Warnock, David W., additional, Warrell, David A., additional, Warrell, Mary J., additional, Warris, Adilia, additional, Watkins, Richard R., additional, Weatherall, David J., additional, Weber, Rainer, additional, Weidner, Wolfgang, additional, White, Jonathan R., additional, White, Peter J., additional, Whitehorn, James, additional, Whitley, Richard J., additional, Whitty, Christopher J.M., additional, Wiersinga, Willem Joost, additional, Wilcox, Mark H., additional, Williams, Thomas N., additional, Wilson, Cara C., additional, Wilson, Mary Elizabeth, additional, Wisplinghoff, Hilmar, additional, Wood, Robin, additional, Wunderink, Richard G., additional, Wyles, David, additional, Yang, Zhi-Tao, additional, Yoder, Jonathan S., additional, Zaidi, Najam A., additional, Zimmer, Andrea J., additional, Zuckerman, Jane N., additional, and Zumla, Alimuddin, additional

Published
2017
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28. Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children

Author

Dewald, Felix, primary, Suárez, Isabelle, additional, Johnen, Ronja, additional, Grossbach, Jan, additional, Moran-Tovar, Roberto, additional, Steger, Gertrud, additional, Joachim, Alexander, additional, Rubio, Gibran Horemheb, additional, Fries, Mira, additional, Behr, Florian, additional, Kley, Joao, additional, Lingnau, Andreas, additional, Kretschmer, Alina, additional, Gude, Carina, additional, Beazes-Flores, Guadelupe, additional, del Valle, David Laveaga, additional, Roblero-Hernandez, Alberto, additional, Magana-Cerino, Jesus, additional, Hernandez, Adriana Torres, additional, Ruiz-Quinones, Jesus, additional, Schega, Konstantin, additional, Linne, Viktoria, additional, Junker, Lena, additional, Wunsch, Marie, additional, Heger, Eva, additional, Knops, Elena, additional, Di Cristanziano, Veronica, additional, Meyer, Meike, additional, Hünseler, Christoph, additional, Weber, Lutz T., additional, Lüers, Jan-Christoffer, additional, Quade, Gustav, additional, Wisplinghoff, Hilmar, additional, Tiemann, Carsten, additional, Zotz, Rainer, additional, Jomaa, Hassan, additional, Pranada, Arthur, additional, Herzum, Ileana, additional, Cullen, Paul, additional, Schmitz, Franz-Josef, additional, Philipsen, Paul, additional, Kirchner, Georg, additional, Knabbe, Cornelius, additional, Hellmich, Martin, additional, Buess, Michael, additional, Wolff, Anna, additional, Kossow, Annelene, additional, Niessen, Johannes, additional, Jeworutzki, Sebastian, additional, Schräpler, Jörg-Peter, additional, Lässig, Michael, additional, Dötsch, Jörg, additional, Fätkenheuer, Gerd, additional, Kaiser, Rolf, additional, Beyer, Andreas, additional, Rybniker, Jan, additional, and Klein, Florian, additional

Published
2022
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29. Longitudinal variability in the urinary microbiota of healthy premenopausal women and the relation to neighboring microbial communities: A pilot study

Author

Biehl, Lena M., primary, Farowski, Fedja, additional, Hilpert, Catharina, additional, Nowag, Angela, additional, Kretzschmar, Anne, additional, Jazmati, Nathalie, additional, Tsakmaklis, Anastasia, additional, Wieters, Imke, additional, Khodamoradi, Yascha, additional, Wisplinghoff, Hilmar, additional, and Vehreschild, Maria J. G. T., additional

Published
2022
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31. Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn)

Author

Salmanton-García, Jon, Seidel, Danila, Koehler, Philipp, Mellinghoff, Sibylle, Herbrecht, Raoul, Klimko, Nikolai, Ráčil, Zdeněk, Falces-Romero, Iker, Ingram, Paul, Benítez-Peñuela, Miguel-Ángel, Rodríguez, José Yesid, Desoubeaux, Guillaume, Barać, Aleksandra, García-Vidal, Carolina, Hoenigl, Martin, Mehta, Sanjay, Cheng, Matthew, Klyasova, Galina, Heinz, Werner, Iqbal, Nousheen, Krause, Robert, Ostermann, Helmut, Penack, Olaf, Schalk, Enrico, Sheppard, Donald, Willinger, Birgit, Wisplinghoff, Hilmar, Vehreschild, J Janne, Cornely, Oliver, Vehreschild, Maria, Khedr, Reham Abdelaziz, Arencibia-Núñez, Alberto, Avilés-Robles, Martha, Banke, Ingo, Basher, Ariful, Benachinamardi, Keertilaxmi, Bertz, Harmut, Chakrabarti, Arunaloke, Drgona, Lubos, García-Martínez, Jesús, García-Rodríguez, Julio, Gräber, Sandra, Härter, Georg, Klein, Michael, Kouba, Michal, Lee, Dong-Gun, Le Govic, Yohann, Leo, Fabian, Maertens, Johan, Maschmeyer, Georg, Meintker, Lisa, Mo, Xiao-Dong, Müller, Lena-Katharina, Müller, Nicolas, Nel, Jeremy Stephen, Novák, Jan, Patel, Atul, Pfäfflin, Frieder, Pozo-Laderas, Juan-Carlos, Puerta-Alcalde, Pedro, Rodríguez-Guardado, Azucena, Schroers, Roland, Shekar, Vandana, Shenoi, Susan, Silling, Gerda, Vinh, Donald, Waizel-Haiat, Salomón, Yee Yee, Mandy Yap, Prakash, Peralam Yegneswaran, Žák, Pavel, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Service d'Hématologie, CHU Strasbourg, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Medicine, Medical University Graz, Schwerpunkt Infektiologie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Department of Haematology and Oncology, Medical Clinic III, University Hospital Munich—Großhadern, Ludwig Maximilian University, Klinik für Hämatologie und Onkologie, Charité, Campus Benjamin Franklin, Department of Haematology/Oncology, Magdeburg University Hospital, McGill University = Université McGill [Montréal, Canada], Medizinische Universität Wien = Medical University of Vienna, University Hospital of Cologne [Cologne], Postgraduate Institute of Medical Education and Research, Laboratoire de psychologie cognitive (LPC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Anofel Cryptosporidium National Network, Department of Hematology, University Hospital Gasthuisberg, Medizinische Klinik, Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Real Expression Artificial Life (IRIT-REVA), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Medizinische Klinik A des Universitätsklinikums Münster, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University Hospital Gasthuisberg [Leuven], Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, 0301 basic medicine, Posaconazole, Antifungal Agents, [SDV]Life Sciences [q-bio], Gastroenterology, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Amphotericin B, Pharmacology (medical), Prospective Studies, Registries, 030212 general & internal medicine, Child, Prospective cohort study, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, ComputingMilieux_MISCELLANEOUS, Antiinfective agent, Standard treatment, Middle Aged, 3. Good health, Infectious Diseases, Tolerability, Child, Preschool, Mucorales, Female, medicine.drug, Adult, Microbiology (medical), medicine.medical_specialty, Adolescent, Drug Compounding, Matched-Pair Analysis, 030106 microbiology, Young Adult, 03 medical and health sciences, Pharmacokinetics, Internal medicine, parasitic diseases, medicine, Humans, Mucormycosis, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [INFO]Computer Science [cs], Aged, Pharmacology, business.industry, Infant, Newborn, Infant, Triazoles, medicine.disease, business, MESH: amphotericin b, antifungal agents, cancer, kidney failure, mucormycosis, surgical procedures, operative, suspensions, mortality, posaconazole, Invasive Fungal Infections
Abstract

Background First-line antifungal treatment for invasive mucormycosis (IM) consists of liposomal amphotericin B. Salvage treatment options are limited and often based on posaconazole oral suspension. With the approval of posaconazole new formulations, patients could benefit from improved pharmacokinetics, safety and tolerability. Objectives Our aim was to assess the effectiveness of posaconazole new formulations for IM treatment. Methods We performed a case-matched analysis with proven or probable IM patients from the FungiScope® Registry. First-line posaconazole new formulations (1st-POSnew) and first-line amphotericin B plus posaconazole new formulations (1st-AMB+POSnew) cases were matched with first-line amphotericin B-based (1st-AMB) treatment controls. Salvage posaconazole new formulations (SAL-POSnew) cases were matched with salvage posaconazole oral suspension (SAL-POSsusp) controls. Each case was matched with up to three controls (based on severity, haematological/oncological malignancy, surgery and/or renal dysfunction). Results Five patients receiving 1st-POSnew, 18 receiving 1st-AMB+POSnew and 22 receiving SAL-POSnew were identified. By day 42, a favourable response was reported for 80.0% (n = 4/5) of patients receiving 1st-POSnew, for 27.8% (n = 5/18) receiving 1st-AMB+POSnew and for 50.0% (n = 11/22) receiving SAL-POSnew. Day 42 all-cause mortality of patients receiving posaconazole new formulations was lower compared with controls [20.0% (n = 1/5) in 1st-POSnew versus 53.3% (n = 8/15) in 1st-AMB; 33.3% (n = 6/18) in 1st-AMB+POSnew versus 52.0% (n = 26/50) in 1st-AMB; and 0.0% (n = 0/22) in SAL-POSnew versus 4.4% (n = 2/45) in SAL-POSsusp]. Conclusions Posaconazole new formulations were effective in terms of treatment response and associated mortality of IM. While posaconazole new formulations may be an alternative for treatment of IM, the limited sample size of our study calls for a cautious interpretation of these observations.

Published
2019

32. SARS-CoV-2 Infection in Fully Vaccinated Individuals of Old Age Strongly Boosts the Humoral Immune Response

Author

Müller, Lisa, primary, Andrée, Marcel, additional, Ostermann, Philipp Niklas, additional, Jazmati, Nathalie, additional, Flüh, Greta, additional, Fischer, Johannes C., additional, Bölke, Edwin, additional, Heger, Eva, additional, Vanshylla, Kanika, additional, Klein, Florian, additional, Wisplinghoff, Hilmar, additional, Schaal, Heiner, additional, Drexler, Ingo, additional, Walker, Andreas, additional, Adams, Ortwin, additional, and Timm, Jörg, additional

Published
2021
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34. Association between the dietary regimen and infection-related complications in neutropenic high-risk patients with cancer

Author

Jakob, Carolin E.M., primary, Classen, Annika Y., additional, Stecher, Melanie, additional, Engert, Andreas, additional, Freund, Meike, additional, Hamprecht, Axel, additional, Jazmati, Nathalie, additional, Wisplinghoff, Hilmar, additional, Hallek, Michael, additional, Cornely, Oliver A., additional, and Vehreschild, Jörg J., additional

Published
2021
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40. SARS-CoV-2, CT-Values, and Infectivity : Conclusions to Be Drawn from Side Observations

Author

Platten, Martin, Hoffmann, Dennis, Grosser, Roger, Wisplinghoff, Fabian, Wisplinghoff, Hilmar, Wiesmüller, Gerhard, Schildgen, Oliver, and Schildgen, Verena

Abstract

Viruses / Molecular Diversity Preservation International 13(8), 1459 (2021). doi:10.3390/v13081459 special issue: "Burden of COVID-19 in Different Countries / Topic Editors: Dr. Dimitrios Paraskevis, Dr. Maria Yavropoulou, Prof. Dr. Sotirios Tsiodras", Published by MDPI, Basel

Published
2021
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41. Lymphogranuloma venereum in men screened for pharyngeal and rectal infection, Germany

Author

Haar, Karin, Dudareva-Vizule, Sandra, Wisplinghoff, Hilmar, Wisplinghoff, Fabian, Sailer, Andrea, Jansen, Klaus, Henrich, Birgit, and Marcus, Ulrich

Subjects
Prevalence studies (Epidemiology), Chlamydia infections -- Risk factors -- Demographic aspects -- Research, Gays -- Health aspects -- Diseases -- Research, Health
Abstract

Lymphogranuloma venereum (LGV) is a sexually transmitted disease caused by infection with Chlamydia trachomatis bacteria, genotypes L1-L3. An outbreak of proctitis cases caused by C. trachomatis genotype L2 in men [...]

Published
2013
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45. Clinical and pharmacoeconomic evaluation of antifungal prophylaxis with continuous micafungin in patients undergoing allogeneic stem cell transplantation: A six‐year cohort analysis

Author

Wingen‐Heimann, Sebastian M., primary, Cornely, Oliver A., additional, Vehreschild, Maria J.G.T., additional, Wisplinghoff, Hilmar, additional, Franke, Bernd, additional, Schons, Max, additional, Bergwelt‐Baildon, Michael, additional, Scheid, Christof, additional, and Vehreschild, Jörg Janne, additional

Published
2021
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46. Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ—Global Registry for Emerging Fungal Infections

Author

Salmanton-García, Jon, primary, Koehler, Philipp, additional, Kindo, Anupma, additional, Falces-Romero, Iker, additional, García-Rodríguez, Julio, additional, Ráčil, Zdeněk, additional, Chen, Sharon C.-A., additional, Klimko, Nikolai, additional, Desoubeaux, Guillaume, additional, Thompson, George R., additional, Benítez-Peñuela, Miguel-Ángel, additional, Rodríguez, José-Yesid, additional, Sheppard, Donald C., additional, Hoenigl, Martin, additional, Le Govic, Yohann, additional, Badali, Hamid, additional, Baddley, John W., additional, Chander, Jagdish, additional, Ingram, Paul R., additional, Pakstis, Diana L., additional, Mellinghoff, Sibylle C., additional, Atıcı, Serkan, additional, Cesaro, Simone, additional, Chakrabarti, Arunaloke, additional, Dupont, Damien, additional, González, Gloria M., additional, Hatvani, Lóránt, additional, Herbrecht, Raoul, additional, Klyasova, Galina, additional, Lass-Flörl, Cornelia, additional, Mareș, Mihai, additional, Mullane, Kathleen, additional, Vinh, Donald C., additional, Wisplinghoff, Hilmar, additional, Lackner, Michaela, additional, Cornely, Oliver A., additional, Seidel, Danila, additional, Alexander, Barbara D., additional, Almagro-Molto, María, additional, Álvarez-Duarte, Eduardo, additional, Avilés-Robles, Martha, additional, Barać, Aleksandra, additional, Chrenková, Vanda, additional, Cornejo-Juárez, Patricia, additional, Desbois-Nogard, Nicole, additional, Fernández-Ruiz, Mario, additional, Figueira, Luis, additional, García-Martínez, Jesús, additional, Gräber, Sandra, additional, Graf, Barbara, additional, Haerter, Georg, additional, Haider, Shariq, additional, Hartman, Pamela, additional, Heinemann, Melina, additional, Ikram, Aamer, additional, Janvier, Frédéric, additional, Jenks, Jeffrey D., additional, Kauffman, Carol, additional, Krause, Robert, additional, Luong, Me-Linh, additional, Malik, Shruti, additional, Marconi, Vincent, additional, Martino, Rodrigo, additional, Mehta, Sanjay R., additional, Meintker, Lisa, additional, Mocná, Andrea, additional, Morris, Michele I., additional, Pasqualotto, Alessandro C., additional, Patel, Atul, additional, Penack, Olaf, additional, Pichon, Nicolas, additional, Pletz, Mathias W., additional, Seas, Carlos, additional, Sili, Uluhan, additional, Slavin, Monica, additional, Uno, Kenji, additional, Vazquez, Jose A., additional, Weber, Thomas, additional, Weinbergerova, Barbora, additional, Yilmaz-Karapinar, Deniz, additional, Yilmaz-Semerci, Seda, additional, and Yu, Jin, additional

Published
2020
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47. Molecular epidemiological typing of Neisseria gonorrhoeae isolates identifies a novel association between genogroup G10557 (G7072) and decreased susceptibility to cefixime, Germany, 2014 to 2017

Author

Banhart, Sebastian, Jansen, Klaus, Buder, Susanne, Tamminga, Thalea, Calvignac-Spencer, Sebastien, Pilz, Tanja, Martini, Andrea, Dudareva, Sandra, Nikisins, Sergejs, Dehmel, Kerstin, Zuelsdorf, Gabriele, Guhl, Eva, Graeber, Ingeborg, Kohl, Peter K., Unemo, Magnus, Bremer, Viviane, Heuer, Dagmar, Back, Thomas, Berger, Anja, Chapot, le Saout, Valerie, Steinmann, Jörg, Eicke, Stephan, Friedrichs, Claudia, Groß, Andreas, Hagedorn, Hans-Jochen, Halfmann, Alexander, Hornei, Britt, Ignatius, Ralf, Korten, Simone, Sahly, Hany, Kozub-Witkowski, Elzbieta, Krämer, Sabine, Kühn, Margit, Liebetrau, Anke, Meyer, Thomas, Oberdorfer, Klaus, Pfüller, Roland, Ruckert, Caroline, Schwarz, Roman, Walch, Daniela, Mai, Madeleine, Wichelhaus, Thomas A., Wisplinghoff, Hilmar, and Wüppenhorst, Nicole

Subjects
0301 basic medicine, medicine.medical_specialty, Epidemiology, business.industry, 030106 microbiology, Public Health, Environmental and Occupational Health, Medizin, Azithromycin, medicine.disease_cause, 03 medical and health sciences, Exact test, 0302 clinical medicine, Antibiotic resistance, Interquartile range, Virology, Internal medicine, medicine, Ceftriaxone, Neisseria gonorrhoeae, 030212 general & internal medicine, Typing, business, Cefixime, medicine.drug
Abstract

Background Emerging antimicrobial resistance (AMR) challenges gonorrhoea treatment and requires surveillance. Aim This observational study describes the genetic diversity of Neisseria gonorrhoeae isolates in Germany from 2014 to 2017 and identifies N. gonorrhoeae multi-antigen sequence typing (NG-MAST) genogroups associated with AMR or some patient demographics. Methods 1,220 gonococcal isolates underwent AMR testing and NG-MAST. Associations between genogroups and AMR or sex/age of patients were statistically assessed. Results Patients’ median age was 32 years (interquartile range: 25–44); 1,078 isolates (88.4%) originated from men. In total, 432 NG-MAST sequence types including 156 novel ones were identified, resulting in 17 major genogroups covering 59.1% (721/1,220) of all isolates. Genogroups G1407 and G10557 (G7072) were significantly associated with decreased susceptibility to cefixime (Kruskal–Wallis chi-squared: 549.3442, df: 16, p Conclusion AMR monitoring with molecular typing is important. Dual therapy (ceftriaxone plus azithromycin) recommended in 2014 in Germany, or only the ceftriaxone dose of this therapy, might have contributed to cefixime-resistant genogroups decreasing.

Published
2020

48. Prediction of advanced fibrosis in non-alcoholic fatty liver disease using gut microbiota-based approaches compared with simple non-invasive tools

Author

Lang, Sonja, Farowski, Fedja, Martin, Anna, Wisplinghoff, Hilmar, Vehreschild, Maria J. G. T ., Krawczyk, Marcin, Nowag, Angela, Kretzschmar, Anne, Scholz, Claus, Kasper, Philipp, Roderburg, Christoph, Lammert, Frank, Goeser, Tobias, Steffen, Hans-Michael, Demir, Münevver, and Publica

Subjects
Adult, Male, Risk, lcsh:Medicine, digestive system, Article, Cohort Studies, Non-alcoholic Fatty Liver Disease, Predictive Value of Tests, NAFLD, RNA, Ribosomal, 16S, Humans, lcsh:Science, Non-alcoholic steatohepatitis, Aged, Sequence Analysis, RNA, lcsh:R, nutritional and metabolic diseases, Middle Aged, Prognosis, Fibrosis, digestive system diseases, Gastrointestinal Microbiome, Liver, Disease Progression, Elasticity Imaging Techniques, lcsh:Q, Female, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Liver fibrosis is the major determinant of liver related complications in patients with non-alcoholic fatty liver disease (NAFLD). A gut microbiota signature has been explored to predict advanced fibrosis in NAFLD patients. The aim of this study was to validate and compare the diagnostic performance of gut microbiota-based approaches to simple non-invasive tools for the prediction of advanced fibrosis in NAFLD. 16S rRNA gene sequencing was performed in a cohort of 83 biopsy-proven NAFLD patients and 13 patients with non-invasively diagnosed NAFLD-cirrhosis. Random Forest models based on clinical data and sequencing results were compared with transient elastography, the NAFLD fibrosis score (NFS) and FIB-4 index. A Random Forest model containing clinical features and bacterial taxa achieved an area under the curve (AUC) of 0.87 which was only marginally superior to a model without microbiota features (AUC 0.85). The model that aimed to validate a published algorithm achieved an AUC of 0.71. AUC’s for NFS and FIB-4 index were 0.86 and 0.85. Transient elastography performed best with an AUC of 0.93. Gut microbiota signatures might help to predict advanced fibrosis in NAFLD. However, transient elastography achieved the best diagnostic performance for the detection of NAFLD patients at risk for disease progression.

Published
2019

49. Staphylococcus lugdunensis pacemaker-related infection

Author

Seifert, Harald, Oltmanns, Dirk, Becker, Karsten, Wisplinghoff, Hilmar, and von Eiff, Christof

Subjects
Pacemaker, Artificial (Heart) -- Health aspects, Staphylococcus aureus -- Case studies, Staphylococcus aureus -- Causes of
Abstract

We report the first known case of a device-related bloodstream infection involving Staphylococcus lugdunensis small-colony variants. Recurrent pacemaker-related bloodstream infection within a period of 10 months illustrates the poor clinical [...]

Published
2005

50. 1172. Mucormycosis Treated with Isavuconazole: A matched-Pair Analysis from the FungiScope® Registry

Author

Seidel, Danila, primary, Cornely, Oliver, additional, Vehreschild, Maria J G T, additional, Koehler, Philipp, additional, Salmanton-García, Jon, additional, Klimko, Nikolay, additional, Herbrecht, Raoul, additional, Heinemann, Melina, additional, Prattes, Jürgen, additional, Schalk, Enrico, additional, Miceli, Marisa H, additional, Ráčil, Zdeněk, additional, Falces-Romero, Iker, additional, Hoenigl, Martin, additional, Kessel, Johanna, additional, Bertz, Hartmut, additional, Novak, Jan, additional, Wisplinghoff, Hilmar, additional, Barmaki-Rad, Farima, additional, Saulay, Mikael, additional, Engelhardt, Marc, additional, and Hamed, Kamal, additional

Published
2020
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