1. Synchronous and Metachronous Peritoneal Metastases in Patients with Left-Sided Obstructive Colon Cancer
- Author
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Veld, Joyce Valerie, Wisselink, Daniel Derk, Amelung, Femke Julie, Consten, Esther Catharina Josephina, de Wilt, Johannes Hendrik Willem, de Hingh, Ignace, Bemelman, Wilhelmus Adrianus, van Hooft, Jeanin Elise, Tanis, Pieter Job, Algera, H., Algie, G. D., Andeweg, C. S., Argillander, T. E., Arron, M. N. N. J., Arts, K., Aufenacker, T. H. J., Bakker, I. S., van Basten Batenburg, M., Bastiaansen, A. J. N. M., Beets, G. L., van den Berg, A., van de Beukel, B., Blom, R. L. G. M., Blomberg, B., Boerma, E. G., den Boer, F. C., Borstlap, W. A. A., Bouvy, N. D., Bouwman, J. E., Boye, N. D. A., Brandt-Kerkhof, A. R. M., Bransma, H. T., Breijer, A., van den Broek, W. T., Bröker, M. E. E., Burbach, J. P. M., Bruns, E. R. J., Burghgraef, T. A., Crolla, R. M. P. H., Daniels, L., Fockens, P., van Halsema, E. E., Lamme, B., Marres, C. C. M., Polle, S. W., Sierink, J. C., Swank, H. A., Tuynman, J. B., van Westreenen, H. L., Wijffels, N. A. T., Graduate School, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, Surgery, Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Microcirculation, and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
- Subjects
medicine.medical_specialty ,Colorectal cancer ,CURATIVE SURGERY ,Perforation (oil well) ,CARCINOMATOSIS ,030230 surgery ,Gastroenterology ,COLORECTAL-CANCER ,Neoplasms, Multiple Primary ,03 medical and health sciences ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,0302 clinical medicine ,All institutes and research themes of the Radboud University Medical Center ,Internal medicine ,medicine ,Humans ,EPIDEMIOLOGY ,Stage (cooking) ,Risk factor ,Peritoneal Neoplasms ,Retrospective Studies ,Colorectal Cancer ,Proportional hazards model ,business.industry ,Incidence (epidemiology) ,Incidence ,Retrospective cohort study ,Neoplasms, Second Primary ,medicine.disease ,Prognosis ,Primary tumor ,HIGH-RISK ,Oncology ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,SURVIVAL ,Surgery ,business ,Colorectal Neoplasms - Abstract
Background Controversy exists on emergency setting as a risk factor for peritoneal metastases (PM) in colon cancer patients. Data in patients with obstruction are scarce. The aim of this study was to determine the incidence of synchronous and metachronous PM, risk factors for the development of metachronous PM, and prognostic implications within a large nationwide cohort of left-sided obstructive colon cancer (LSOCC). Methods Patients with LSOCC treated between 2009 and 2016 were selected from the Dutch ColoRectal Audit. Additional treatment and long-term outcome data were retrospectively collected from original patient files in 75 hospitals in 2017. Results In total, 3038 patients with confirmed obstruction and without perforation were included. Synchronous PM (at diagnosis or p p Conclusion This population based study revealed a 5.0% incidence of synchronous peritoneal metastases in patients who underwent resection of left-sided obstructive colon cancer. The subsequent 3-year cumulative metachronous PM rate was 9.9%, with advanced tumor and nodal stage as independent risk factors for the development of PM.
- Published
- 2020
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