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149 results on '"Wlaź, Aleksandra"'

11. Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt, Slc6a15 and Adora1 gene expression

Author

Szopa, Aleksandra, Doboszewska, Urszula, Herbet, Mariola, Wośko, Sylwia, Wyska, Elżbieta, Świąder, Katarzyna, Serefko, Anna, Korga, Agnieszka, Wlaź, Aleksandra, Wróbel, Andrzej, Ostrowska, Marta, Terlecka, Joanna, Kanadys, Adam, Poleszak, Ewa, Dudka, Jarosław, and Wlaź, Piotr

Published
2017
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13. Withdrawal of caffeine after its chronic administration modifies the antidepressant-like activity of atypical antidepressants in mice. Changes in cortical expression of Comt, Slc6a15 and Adora1 genes

Author

Szopa, Aleksandra, Poleszak, Ewa, Doboszewska, Urszula, Herbet, Mariola, Świąder, Katarzyna, Wyska, Elżbieta, Serefko, Anna, Wlaź, Aleksandra, Korga, Agnieszka, Ostrowska, Marta, Juś, Piotr, Jedynak, Szymon, Dudka, Jarosław, and Wlaź, Piotr

Published
2018
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19. Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice

Author

Poleszak, Ewa, Wośko, Sylwia, Sławińska, Karolina, Wyska, Elżbieta, Szopa, Aleksandra, Świąder, Katarzyna, Wróbel, Andrzej, Szponar, Jarosław, Doboszewska, Urszula, Wlaź, Piotr, Wlaź, Aleksandra, and Serefko, Anna

Abstract

Background: Though there are several classes of antidepressant drugs available on the pharmaceutical market, depression that affects globally over 320 million people is still undertreated. Scientists have made attempts to develop novel therapeutical strategies to maximize effectiveness of therapy and minimize undesired reactions. One of the ideas is use of either dual-action agents or combined administration of two substances that affect diverse neurotransmissions. Thus, we investigated whether the selected CB receptor ligands (oleamide, AM251, JWH133, and AM630) can have an impact on the activity of bupropion and moclobemide. Bupropion belongs to the dual acting drugs, whereas moclobemide is an inhibitor of monoamine oxidase. Methods: The mice forced swim test and the tail suspension test were applied in order to determine the potential antidepressant-like activity, whereas the HPLC method was used in order to assess the brain concentrations of the tested antidepressants. Results: An intraperitoneal injection of sub-effective doses of oleamide (5 mg/kg), AM251 (0.25 mg/kg), and AM630 (0.25 mg/kg) increased activity of bupropion (10 mg/kg) in both behavioural tests. Effects of moclobemide (1.5 mg/kg) were potentiated only by AM251. These results were not influenced by the hypo- or hyperlocomotion of animals. Conclusion: The outcomes of the present study revealed that particularly activation or inhibition of the CB1receptor function may augment the antidepressant activity of bupropion, whereas only inhibition of the CB1receptor function manages to increase activity of moclobemide. Most probably, an interplay between CB receptor ligands and bupropion or moclobemide takes place at the cellular level.

Published
2024
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32. The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies

Author

Szopa, Aleksandra, primary, Bogatko, Karolina, additional, Herbet, Mariola, additional, Serefko, Anna, additional, Ostrowska, Marta, additional, Wośko, Sylwia, additional, Świąder, Katarzyna, additional, Szewczyk, Bernadeta, additional, Wlaź, Aleksandra, additional, Skałecki, Piotr, additional, Wróbel, Andrzej, additional, Mandziuk, Sławomir, additional, Pochodyła, Aleksandra, additional, Kudela, Anna, additional, Dudka, Jarosław, additional, Radziwoń-Zaleska, Maria, additional, Wlaź, Piotr, additional, and Poleszak, Ewa, additional

Published
2021
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34. Influence of the CB1 cannabinoid receptors on the activity of the monoaminergic system in the behavioural tests in mice

Author

Poleszak, Ewa, primary, Wośko, Sylwia, additional, Sławińska, Karolina, additional, Wyska, Elżbieta, additional, Szopa, Aleksandra, additional, Doboszewska, Urszula, additional, Wlaź, Piotr, additional, Wlaź, Aleksandra, additional, Dudka, Jarosław, additional, Szponar, Jarosław, additional, and Serefko, Anna, additional

Published
2019
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37. Antidepressant-Like Activity of Typical Antidepressant Drugs in the Forced Swim Test and Tail Suspension Test in Mice Is Augmented by DMPX, an Adenosine A2A Receptor Antagonist

Author

Poleszak, Ewa, primary, Szopa, Aleksandra, additional, Bogatko, Karolina, additional, Wyska, Elżbieta, additional, Wośko, Sylwia, additional, Świąder, Katarzyna, additional, Doboszewska, Urszula, additional, Wlaź, Aleksandra, additional, Wróbel, Andrzej, additional, Wlaź, Piotr, additional, and Serefko, Anna, additional

Published
2018
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42. Phacotrabeculectomy using collagen matrix implant (Ologen®) versus mitomycin C: a prospective randomized controlled trial.

Author

Wlaź, Aleksandra, Wilkos‐Kuc, Agnieszka, Rozegnał‐Madej, Agnieszka, and Żarnowski, Tomasz

Subjects
*MITOMYCIN C, *TRABECULECTOMY, *COLLAGEN, *PHACOEMULSIFICATION, *INTRAOCULAR pressure, *TREATMENT effectiveness
Abstract

Purpose: To compare the efficacy and safety of collagen matrix implant (Ologen®; OLO) with mitomycin C (MMC) in phacotrabeculectomy. Methods: Prospective, single‐centre, nonblinded, randomized controlled trial. A total of 53 eyes of 45 patients were enrolled in the study protocol with 27 eyes randomly assigned to OLO and 26 to MMC. The follow‐up was 12 months. The primary outcome measure was mean change from baseline intraocular pressure (IOP) in both groups after 12 months. The secondary outcome measures were cumulative success rates at 12 months with Kaplan–Meier analysis, change in number of medications, change in best corrected visual acuity (BCVA), and bleb morphology assessed using Moorfields Bleb Grading System and anterior segment swept‐source optical coherence tomography. Results: The mean IOP decreased from 26.4 ± 6.1 mmHg to 13.7 ± 3.8 in the OLO group and from 23.4 ± 3.6 mmHg to 13.3 ± 2.8 in the MMC group at 1 year without significant intergroup differences. At 1 year, the overall success rates were 92.6% and 92.3% in the OLO and MMC groups, respectively. There were no significant differences in the overall success rates, BCVA, number of medications, morphology of the filtering blebs and rate of complications at the end of the follow‐up. Conclusion: Ologen (OLO) provides similar surgical outcomes in phacotrabeculectomy compared with adjunctive MMC. It may be a new, safe and effective alternative to MMC for combined phacoemulsification and trabeculectomy surgery. [ABSTRACT FROM AUTHOR]

Published
2019
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43. Antidepressant-Like Activity of Typical Antidepressant Drugs in the Forced Swim Test and Tail Suspension Test in Mice Is Augmented by DMPX, an Adenosine A2A Receptor Antagonist.

Author

Poleszak, Ewa, Szopa, Aleksandra, Bogatko, Karolina, Wyska, Elżbieta, Wośko, Sylwia, Świąder, Katarzyna, Doboszewska, Urszula, Wlaź, Aleksandra, Wróbel, Andrzej, Wlaź, Piotr, and Serefko, Anna

Subjects
ANTIDEPRESSANTS, SEROTONIN uptake inhibitors, ADENOSINE triphosphate, ESCITALOPRAM, ADRENERGIC uptake inhibitors
Abstract

Unsatisfactory therapeutic effects of currently used antidepressants force to search for new pharmacological treatment strategies. Recent research points to the relationship between depressive disorders and the adenosinergic system. Therefore, the main goal of our studies was to evaluate the effects of DMPX (3 mg/kg, i.p.), which possesses selectivity for adenosine A2A receptors versus A1 receptors, on the activity of imipramine (15 mg/kg, i.p.), escitalopram (2.5 mg/kg, i.p.), and reboxetine (2 mg/kg, i.p.) given in subtherapeutic doses. The studies carried out using the forced swim and tail suspension tests in mice showed that DMPX at a dose of 6 and 12 mg/kg exerts antidepressant-like effect and does not affect the locomotor activity. Co-administration of DMPX at a dose of 3 mg/kg with the studied antidepressant drugs caused the reduction of immobility time in both behavioral tests. The observed effect was not associated with an increase in the locomotor activity. To evaluate whether the observed effects were due to a pharmacokinetic/pharmacodynamic interaction, the levels of the antidepressants in blood and brain were measured using high-performance liquid chromatography. It can be assumed that the interaction between DMPX and imipramine was exclusively pharmacodynamic in nature, whereas an increased antidepressant activity of escitalopram and reboxetine was at least partly related to its pharmacokinetic interaction with DMPX. [ABSTRACT FROM AUTHOR]

Published
2019
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45. CB1 cannabinoid receptor ligands augment the antidepressant-like activity of biometals (magnesium and zinc) in the behavioural tests.

Author

Wośko, Sylwia, Serefko, Anna, Szopa, Aleksandra, Wlaź, Piotr, Wróbel, Andrzej, Wlaź, Aleksandra, Górska, Jolanta, and Poleszak, Ewa

Subjects
CANNABINOID receptors, ANTIDEPRESSANTS, THERAPEUTIC use of zinc, THERAPEUTIC use of magnesium, LOCOMOTOR control
Abstract

Objective During the last few decades, endocannabinoid system has emerged as a novel possible target for antidepressant treatment. Although the medical literature provides information on the mood-changing effects of CB1 ligands, little is known about the possible interaction between the simultaneous activation or inhibition of the CB1 receptor and administration of other agents that possess antidepressant potential. The main goal of our study was to evaluate the influence of the CB1 cannabinoid receptor ligands (oleamide -- an endogenous agonist and AM251 -- an inverse agonist/antagonist) on the antidepressant-like activity of biometals (i.e. magnesium and zinc). Methods The forced swim test and the tail suspension test in mice were used to determine the antidepressant-like activity. Key findings Concomitant intraperitoneal administration of per se inactive doses of oleamide (5 mg/kg) or AM251 (0.25 mg/kg) and the tested biometals (i.e. magnesium, 10 mg/kg or zinc, 5 mg/kg) shortened the immobility time of animals in the forced swim test and the tail suspension test. The observed effect was not associated with an increase in spontaneous locomotor activity of mice. Conclusions The simultaneous modulation of the cannabinoid system and supplementation of magnesium or zinc produce at least additive antidepressant-like effect. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2Areceptor antagonist, but not DPCPX, a selective adenosine A1receptor antagonist

Author

Szopa, Aleksandra, Bogatko, Karolina, Serefko, Anna, Wyska, Elżbieta, Wośko, Sylwia, Świąder, Katarzyna, Doboszewska, Urszula, Wlaź, Aleksandra, Wróbel, Andrzej, Wlaź, Piotr, Dudka, Jarosław, and Poleszak, Ewa

Abstract

Adenosine, an endogenous nucleoside, modulates the release of monoamines, e.g., noradrenaline, serotonin, and dopamine in the brain. Both nonselective and selective stimulation of adenosine receptors produce symptoms of depression in some animal models. Therefore, the main objective of our study was to assess the influence of a selective adenosine A1receptor antagonist (DPCPX) and a selective adenosine A2Areceptor antagonist (DMPX) on the activity of agomelatine and tianeptine.

Published
2019
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47. NMDA and AMPA receptors are involved in the antidepressant-like activity of tianeptine in the forced swim test in mice

Author

Kasperek Regina, Nowak Gabriel, Wróbel Andrzej, Szumiło Michał, Wlaź Piotr, Poleszak Ewa, and Wlaź Aleksandra

Subjects
Pharmacology, Male, Chemistry, Depression, Thiazepines, Glutamate receptor, Antagonist, General Medicine, AMPA receptor, Antidepressive Agents, Tricyclic, Motor Activity, Serotonergic, Receptors, N-Methyl-D-Aspartate, chemistry.chemical_compound, Mice, medicine, NMDA receptor, Animals, NBQX, Tianeptine, Receptors, AMPA, Swimming, Behavioural despair test, medicine.drug
Abstract

It is known that tianeptine exhibits antidepressant-like activity. Its influence on the glutamatergic system is also known, but the mechanisms involved in this activity remain to be established. The aim of this study was to investigate the involvement of the glutamate pathway in the antidepressant-like action of tianeptine. We investigated the effects of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor ligands on tianeptine-induced activity in the forced swim test (FST) in mice. The antidepressant-like activity of tianeptine (30 m/kg, ip) was significantly antagonized by D-serine (100 nmol/mouse icv) and NBQX (10 mg/kg, ip). Moreover, low, ineffective doses of the glycine/NMDA site antagonist L-701,324 (1 mg/kg, ip) administered together with low, ineffective doses of tianeptine (20 mg/kg, ip) exhibited a significant reduction of immobility time in the FST. These doses of the examined agents, which did have an effect in the FST, did not alter locomotor activity. The present study indicates that the antidepressant-like activity of tianeptine in the FST involves both NMDA and AMPA receptors and suggests that the interaction between serotonergic and glutamatergic transmission may play an important role in the action of tianeptine.

Published
2011

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